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1

McElearney, Catherine, Carol Fitzpatrick, Niamh Farrell, Mary King, and Bryan Lynch. "Stimulant medication in ADHD: what do children and their parents say?" Irish Journal of Psychological Medicine 22, no. 1 (2005): 5–9. http://dx.doi.org/10.1017/s0790966700008715.

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AbstractObjectives: The prescription of stimulant medication to children with attention deficit hyperactivity disorder remains topical. Few reports target children's views about taking long-term medication. The aim was to assess child and parent views of stimulant medication. To compare attitudes to medication between two groups of children, those with attention deficit hyperactivity disorder taking stimulant medication and those with epilepsy taking anti-epileptic medication.Method: Forty children (n = 40) with attention deficit hyperactivity disorder on stimulant medication, and 40 children (n = 40) with epilepsy on anti-epileptic medication formed the study population. A semi-structured interview was carried out with each child and parent. Each parent completed the Dosage and Side-effects Questionnaire and the Attitude to Medication Questionnaire. Each child completed the Attitude to Medication Questionnaire.Results: Sixty per cent of children (n = 24) with attention deficit hyperactivity disorder and 62.5% (n = 25) of those with epilepsy knew the name and purpose of their medication. Forty per cent (n = 16) of children in the stimulant group and 32.5% (n = 13) in the anti-epileptic group reported themselves as being non-compliant with medication. In both groups children reported positive aspects to taking medication. More children with epilepsy reported negative aspects. Only 32.5% (n = 13) of children with attention deficit hyperactivity disorder said that they would tell a friend about their medication, while 55% (n = 22) of the children with epilepsy indicated that they would do so. In both groups parents were better informed than their children were about the purpose of the medication. Parents of children with attention deficit hyperactivity disorder tended to be more positive about medication than their children and than the parents in the comparison group.Conclusions: The majority of children and their parents express positive views about the stimulant medication. Children's views about medication compliance and side-effects should be sought, as they may differ significantly from those of their parents. Where parents have noticed positive changes, but children have not, this information can be used therapeutically to help children feel more in control of their behaviour.
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2

Morozov, D. V. "EEG changes in children born to epileptic parents." Neurology, Neuropsychiatry, Psychosomatics, no. 1S (March 18, 2015): 15. http://dx.doi.org/10.14412/2074-2711-2015-1s-15-18.

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3

Goti, Ashish, Rameshkumar Dihora, and Sweta Desai. "Assessment of quality of life in parents of epileptic children and its associated factors." International Journal of Contemporary Pediatrics 7, no. 9 (2020): 1837. http://dx.doi.org/10.18203/2349-3291.ijcp20203509.

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Background: Aim of the study was to assess quality of life (QOL) of parents of epileptic child and its association with various factors like demographic, clinical, therapeutic and behavioral factors.Methods: Consenting parents of 160 epileptic children were enrolled after finishing child’s visit to the pediatrician. Parents were enquired on baseline demographic variables like age, gender, socio-economic status, parental education; clinical details like type of epilepsy, duration of seizure, seizure frequency and co-morbidity and therapeutic factors like treatment of epilepsy and adverse drug reactions. QOL was evaluated using QOLCE questionnaire and Childhood Illness-related Parenting Stress Inventory and analysed.Results: Out of 160 parents, 85% belong to 30-40 years of age and 62.5% were male. Deteriorated quality of life was reported by parents as mean score 63.46±7.69. QOL was significantly poor (p<0.05) in parents of younger child (<6 yrs), education status (upto primary school only), employment status of parent (unemployed) and lower socioeconomic status. Assessment of disease related parameters revealed that type of seizure, seizure frequency, duration and co-morbidity were factors significantly affecting quality of life of parents with lower QOL scores(p<0.05). QOL of parents of child with epilepsy undergoing polytherapy with multiple AEDs treatment, particle seizure control and having adverse drug reaction were associated with poor scores of health and well being (p<0.05). It was found that parents of epileptic child had deteriorated QOL score with respect to behaviour patterns irrespective to conditions of epilepsy due to constant stress and anxiety and poor state of mind.Conclusions: QOL of parents was compromised in Indian children with epilepsy. Demographic factors like age of child, parental education, socio-economic status and clinical factors like type of seizure, frequency & duration of seizure and co-morbid conditions significantly affect the QOL of parents. Significantly poor QOL scores was also due to therapeutic factors like treatment with polytherapy and adverse drug reactions with poor behavioral patterns which was observed in parents that should be taken care and should not be overlooked.
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Varghese, Alexis, and Monika Sharma. "Talk to parents: Bridge the knowledge gap in parents with epileptic children." CHRISMED Journal of Health and Research 6, no. 4 (2019): 204. http://dx.doi.org/10.4103/cjhr.cjhr_5_19.

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5

Ülgey, Ayşe, Recep Aksu, and Cihangir Bicer. "Nasal and Buccal Treatment of Midazolam in Epileptic Seizures in Pediatrics." Clinical Medicine Insights: Pediatrics 6 (January 2012): CMPed.S8330. http://dx.doi.org/10.4137/cmped.s8330.

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Acute seizure and status epilepticus constitute major medical emergencies in children. Four to six percent of children will have at least one seizure in the first 16 years of life. Status epilepticus is a common neurological emergency in childhood and is associated with significant morbidity and mortality. The early application of antiepileptic treatment is very important. Because early treatment prevents the status epilepticus formation and shortens the duration of seizure activity. For this reason administration of anticonvulsant therapy in the prehospital setting is very important. Seizures generally begin outside the hospital, and thus parents and caregivers need simple, safe and effective treatment options to ensure early intervention. The only special preparation used for this purpose is rectal diazepam but has some disadvantages. Midazolam is a safe, short-acting benzodiazepin. It is suitable to use oral, buccal, nasal, im and iv routes. This provides a wide area for clinical applications. Recently there are many clinical studies about the usage of nasal and buccal midazolam for treatment of pediatric epileptic seizures. The nasal and buccal applications in pediatric seizures are very practical and effective. Parents and caregivers can apply easily outside the hospital.
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6

Talarska, Dorota, Barbara Steinborn, and Michał Michalak. "Cognitive functioning and behaviour of epileptic children in parents' assessment." Neurologia i Neurochirurgia Polska 45, no. 5 (2011): 474–79. http://dx.doi.org/10.1016/s0028-3843(14)60316-9.

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7

Friis, M. L., and M. Hauge. "Congenital Heart Defects in Live-born Children of Epileptic Parents." Archives of Neurology 42, no. 4 (1985): 374–76. http://dx.doi.org/10.1001/archneur.1985.04060040084018.

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8

Doan, Tri, Tuan Tran, and Han Nguyen. "The Vietnamese Version of the Health-related Quality of Life Measure for Children with Epilepsy (CHEQOL-25): Reliability." MedPharmRes 1, no. 1 (2017): 9–14. http://dx.doi.org/10.32895/ump.mpr.1.1.9/suffix.

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Purpose: This study aimed to translate and culturally adapt the self-report and parent-proxy Health-Related Quality of Life Measure for Children with Epilepsy (CHEQOL-25) into Vietnamese and to evaluate their reliability. Methods: Both English versions of the self-report and parent-proxy CHEQOL-25 were translated and culturally adapted into Vietnamese by using the Principles of Good Practice for the Translation and Cultural Adaptation Process. The Vietnamese versions were scored by 77 epileptic patients, who aged 8–15 years, and their parents/caregivers at neurology outpatient clinic of Children Hospital No. 2 – Ho Chi Minh City. Reliability of the questionnaires was determined by using Cronbach’s coefficient α and intra-class correlation coefficient (ICC). Results: Both Vietnamese versions of the self-report and parent-proxy CHEQOL-25 were shown to be consistent with the English ones, easy to understand for Vietnamese children and parents. Thus, no further modification was required. Cronbach’s α coefficient for each subscale of the Vietnamese version of the self-report and parent-proxy CHEQOL-25 was 0.65 to 0.86 and 0.83 to 0.86, respectively. The ICC for each subscale of the self-report and parent-proxy CHEQOL-25 was in the range of 0.61 to 0.86 and 0.77 to 0.98, respectively. Conclusion: The Vietnamese version of the self-report and parent-proxy CHEQOL-25 were the first questionnaires about quality of life of epileptic children in Vietnam. This Vietnamese version was shown to be reliable to assess the quality of life of children with epilepsy aged 8–15 years.
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Kats, Daniel J., Vasiliki Patsiogiannis, and Brian G. Skotko. "Epileptic Spasms in Patients With Down Syndrome: Experiences From Caregivers." Journal of Child Neurology 35, no. 12 (2020): 813–19. http://dx.doi.org/10.1177/0883073820932770.

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Epileptic spasms are the most common type of seizure in infants with Down syndrome; however, the scope of current literature is largely limited to treatment options. We performed a chart review of patients seen at a Down syndrome specialty clinic to identify potential developmental sequelae of Down syndrome and epileptic spasms. We further interviewed parents of the children with Down syndrome and epileptic spasms to identify areas for improvement in counseling, diagnosis, and follow-up. Persistent developmental delays and autism spectrum disorder were highly prevalent in our patients. Caregivers attributed delays in treatment to insufficient counseling and awareness of epileptic spasms. They also identified inadequate emotional support after the diagnosis of the spasms. When counseling parents of infants with Down syndrome, pediatricians should educate about epileptic spasms. If spasms are diagnosed, providing emotional support with frequent follow-up is important. Furthermore, clinicians should monitor for signs of epilepsy and autism spectrum disorder.
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Knezevic-Pogancev, Marija. "Cerebral palsy and epilepsy." Medical review 63, no. 7-8 (2010): 527–30. http://dx.doi.org/10.2298/mpns1008527k.

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Introduction. Cerebral palsy is the most common cause of physical disability in early childhood. Epilepsy is known to have a high association with cerebral palsy. All types of epileptic seizures can be seen in patients with cerebral palsy. Complex partial and secondary generalized ones are the most frequent seizure types. In persons with cerebral palsy and mental retardation, the diagnosis of epilepsy presents unique difficulties. Generally they are not able to describe the epileptic events themselves, parents are not able to describe them without fear and persons trained in epilepsy witness the events only rarely. Some syndromes, such as infantile spasms, West and Lennox-Gastaut syndrome, are particularly frequent, whereas children with cerebral palsy are rarely free of epilesy. It has been observed that epileptic seizures in children with cerebral palsy tend to have an earlier onset; they often appear in children with cerebral palsy and mental retardation; they are more severe in patients with a more severe degree of cerebral palsy. The overall outcome of seizures in children with cerebral palsy is poor, requiring prolonged course of antiepileptic medications, polytherapy with higher incidence of refractory seizures and hospital admissions for status epilepticus. The presence of a neurological deficit, as well as cerebral palsy, does not necessarily mean a poor prognosis after the discontinuation of antiepileptic drugs, but the risk of a relaps in persons with cerebral palsy is high. Aim. The objective of the paper was to show the relationship between cerebral palsy and epilepsy and to determine the occurrence, associated factors, nature and prognosis of epilepsy in children with cerebral palsy.
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Dudarevič, Tatjana, and Zyta Kuzborska. "Education of Parents of Epilepsy Children." Slauga. Mokslas ir praktika 2, no. 5 (293) (2021): 8–15. http://dx.doi.org/10.47458/2021.2.9.

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Epilepsy is a many-sided disease that manifests itself as seizures of various kinds and origin, which can start at any age, often in childhood. The nursing, training and treatment of a sick child have serious implications for the whole family. The most significant factor becomes the ability of a nurse to impart existing professional knowledge to a patient and his or her family and to teach about disease control measures. More informed patients and their families feel more in control of their illness than less informed patients and their relatives. People with epilepsy and the general public lack general information about the condition, knowledge about care and how to deliver it, and access to services. Educating loved ones is a key tool in disease control and prevention.The research was conducted in October and November of 2019 in one of the city hospitals in Vilnius. The analysis of questionnaire data before the training revealed that parents whose children suffer from epilepsy have lack of information about the disease. The questionnaire data after the training showed that parents acquired more knowledge and the results improved. The majority of parents whose children suffer from epilepsy is well informed about the disease. However, they have a lack of knowledge in relation to the factors provoking epileptic seizures. Besides, they are not aware when it is necessary to call the ambulance and when to use first aid medicines. The parents are interested in innovations related to epilepsy, treatment and care of a sick child. All the parents have a need to gain knowledge about the disease. The comparison of parents’ awareness of the disease before and after the training showed that parents had learnt to provide aid correctly during seizures. The training was effective.
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12

Kinkar, Abdulelah, Dalya Alqarni, Abdulaziz Alghamdi, et al. "Parental Knowledge, Attitudes, and Behaviors Toward Their Epileptic Children at King Abdulaziz University Hospital: Cross-Sectional Study." Interactive Journal of Medical Research 9, no. 1 (2020): e12697. http://dx.doi.org/10.2196/12697.

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Background Epilepsy is a chronic disease characterized by periodic seizures that result from abnormal integrated firing impulses in the brain. It is one of the most common neurological disorders. Over the past few years, there has been increasing awareness about the effect that having a child with epilepsy has on parents and the reciprocal impact of parental knowledge and attitudes regarding epilepsy on the affected child. Objective This study aimed to assess parental knowledge, attitudes, and behavior toward their epileptic children. Methods A cross-sectional study was conducted in 2018 by the Pediatric Neurology Department of King Abdulaziz University Hospital, Jeddah, the Kingdom of Saudi Arabia. A sample size of 115 of 332 parents who have a child diagnosed with epilepsy and aged 18 years or younger were recruited for this study. Statistical analysis was performed using SPSS version 21. Data analysis was performed using an independent t test, a chi-square test, one-way analysis of variance, and correlation analysis. Results A total of 115 participants answered the questionnaire; of these, 65 (56.5%) were men, with an average age of 40.3 years, and the mean age of the children was 9.0 years. Overall, 85 (85/115, 73.9%) children were taken care of by both of their parents. The mean parental knowledge score was 7.49 (SD 2.08) out of 12, and it was significantly related to the educational level of the parent (P=.004). The knowledge question that was most frequently answered incorrectly was “Diagnosis of epilepsy is usually made based on at least two unprovoked seizures.” As only 28.7% (33/115) of participants chose the correct answer, mean parental attitude score was 26.51 (SD 4.284) out of 35, and there was no significant relation with the educational level of parents (P=.13); however, it was negatively correlated with the child’s age (P=.045). Mean parental behavioral score was 23.35 (SD 4.121) out of 35, and there was no significant relation with the educational level of the parents (P=.24). The most negatively answered question for the behavior section was “I can leave my child without supervision,” with a mean score of 2.25 (SD 1.09) out of 5. Gender did not play a significant role in parental knowledge, attitudes, or behavior (P=.44, P=.77, and P=.99, respectively). Conclusions Parental knowledge in our sample still needs improvement. Therefore, more awareness campaigns should be made for the community and for the parents of affected children to create a supportive environment for the children and help them thrive and develop.
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Ibekwe, Roland C., and Ngozi C. Ojinnaka. "Childhood epilepsy and school absence." Tropical Doctor 38, no. 4 (2008): 258–59. http://dx.doi.org/10.1258/td.2007.070305.

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Epilepsy is one of the most common diseases encountered among school children. Its effect on school attendance and academic performance is a major cause of concern to both parents and clinicians. In this communication, the absence rate and academic performance of 50 school children with epilepsy attending normal schools was compared with that of their age- and sex-matched classmates using the class attendance register and overall score of the 2001/2002 academic year. The mean and standard deviation of the number of days an epileptic child was absent in the 2001/2002 session was 15.3 + 13.8 days while that of the controls was 9.4 + 9.6 days (x2 = 3.4,df = 49, p < 0.001). There was no significant relationship between the rate of absenteeism and overall score among both epileptic children (x2 = 6.34, df = 2, p = 0.18) and the controls (x2 = 1.43, df = 2, p = 0.49). School absenteeism was therefore more common among epileptic children, though there was no observed negative effect of this increased absence on academic performance.
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Turovskaya, N. G. "Neuropsychological Qualification of Mental Development Characteristics of Children with Non-Epileptic Paroxysmal Conditions in Anamnesis." Клиническая и специальная психология 5, no. 1 (2016): 77–92. http://dx.doi.org/10.17759/cpse.2016050106.

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The article deals with the research results of mental development specificity among children with certain non-epileptic paroxysmal conditions in the past medical history. Participants of the research were 107 children from 6 to 10 years old and their parents. Clinical, biographical and experimental psychological methods were used. The empirical study has showed that affect-respiratory attacks combine with the most pronounced mental functions disorders (including thinking and active attention) comparing to other non-epileptic paroxysmal conditions. Children with febrile spasms in anamnesis have disorders of certain mental functions (including thinking) with a low to medium degree and strong disorders of active attention. Vegetovisceral seizures don’t combine with thought disorders in children and are associated with a low degree disorder of active attention. Taking into consideration these findings it is possible to reveal the effective psychological ways for helping children with the pathology.
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Afzal, Erum, Waqas Imran Khan, Mohammad Khalid Iqbal, Kausar Aftab, and Tanveer Ahmad. "Prevalence of psychosocial problems in children with and without epilepsy: A comparative cross-section study." Professional Medical Journal 28, no. 04 (2021): 557–63. http://dx.doi.org/10.29309/tpmj/2021.28.04.5800.

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Objectives: To compare the prevalence of psychosocial problems in children with and without epilepsy. Study Design: Comparative Cross Sectional study. Settings: The Children’s Hospital and The Institute of Child Health Multan (CH & ICH). Period: July 2019 to December 2019. Material & Methods: Fifty-nine patients of either gender, 5 -12 years of age, diagnosed as Epilepsy were included in group A. For the group B the patient of same number, age and gender without epilepsy visiting the general outpatient department of the hospital with acute illness were included. The children having known psychiatric disorder, and intellectual disability were excluded. Educational level of parents, socioeconomic status, Time of onset, type, outcome of epilepsy, number of antiepileptic medicines used and EEG findings were noted. Intelligence Quotient of each patient was calculated. A Pediatric Symptom Checklist was used for psychosocial problems in all children. Data was analyzed by using SPSS version 20. Result: Out of 118 patients (59 in group A and 59 in group B), 68% (n=73) were male. Mean age of the participants was 10.2years (st dev.±11.1). Patients age ranging between 5-9 years constituted 32% (n=38) while 68% (n=80) were more than 9 to 12 years. Most of the children belonged to low socioeconomic status 66% (n=78). Educational level of parents was below matric in 67.8% (n=80) and 32.2% (n=38) were above matric. In Group A 64.41% (n=38) patients had generalized tonic clonic type of epilepsy, 28.81% (n=17) partial/focal type and 3.39% (n= 2) myoclonic type. In 42% (n=52) of patient’s epilepsy was controlled while in 58% (n=7) patients it was uncontrolled. Psychosocial problems were detected in 59.3% (n=35) patients in epileptic group A while in 23.7% (n=14) in non-epileptic group B. Single use of antiepileptic was important factor causing psychosocial problems in epileptic children. Conclusion: Psychosocial problems are more common in Epileptic children, so psychological evaluation and management must be integral part of their therapy.
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Elmohalem, Rasha Ibrahime Bakier, Safaa Salah Ismail, and Madiha Hassan Bayomi. "Assessment of Parents' Knowledge, Practices and Attitude Toward Care for Their Epileptic Children." Egyptian Journal of Health Care 11, no. 3 (2020): 144–62. http://dx.doi.org/10.21608/ejhc.2020.109226.

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17

Miziara, Carmen Silvia M. G., and Maria Luiza G. Manreza. "Benign focal epilepsy of childhood with centrotemporal spikes (BECTS): clinical characteristics of seizures according to age at first seizure." Arquivos de Neuro-Psiquiatria 60, no. 2B (2002): 390–94. http://dx.doi.org/10.1590/s0004-282x2002000300010.

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BECTS is characterized by the presence of simple partial motor seizures in the face and/or oropharynx, with or without sensory symptoms and often with secondary generalization. These seizures tend to occur more often during sleep or drowsiness. According to some authors, generalized seizures prevail over other types particularly among children aged five or less. The purpose of this study is to determine the characteristics of the first epileptic episode among children with BECTS, grouped by age as of their first epileptic seizure, as well as to analyze how such seizures change over the course of clinical evolution. A total of 61 children were examined, 16 of whom below the age of 5 and 45 above. With regard to the first and recurrent epileptic episodes, our final assessment showed that partial seizures occurred more frequently than generalized tonic-clonic seizures in both groups. Although no conclusive relation could be established between the type of partial seizure (i.e. simple versus complex) and the children's age as of their first epileptic episode, it was possible to correlate the type of epileptic seizure with their clinical evolution, in which case simple partial seizures proved to be more frequent than complex partial seizures. It should be noted that the number of children under the age of five was relatively small, which evinces the need for further studies. It should also be borne in mind that the reported frequency of generalized seizures in these children's first epileptic episode may be due to their parents' lack of attention and familiarity with this pathology and their attendant difficulty in characterizing its clinical symptoms.
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Kaushik, Sundeep, Deepti Chopra, Suvasini Sharma, and Satinder Aneja. "Adverse Drug Reactions of Anti-Epileptic Drugs in Children with Epilepsy: A Cross-Sectional Study." Current Drug Safety 14, no. 3 (2019): 217–24. http://dx.doi.org/10.2174/1574886314666190311112710.

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Background: Adverse drug reactions (ADRs) due to antiepileptic drugs (AEDs) in children contribute to poorer patient outcomes. However, reliable data ragarding such ADRs is not available. Objectives: Thus, the aim of the present study was to determine the incidence and patterns of ADRs of antiepileptic drugs in children aged 2-17 years presenting to a tertiary care teaching hospital. Methods: An observational study was conducted in the Department of Pediatrics, Kalawati Saran Children’s Hospital for a period of one year. Two hundred consecutive eligible patients (aged 2-17 yrs with epilepsy on AED) with consenting parents were enrolled. ADRs were noted using Paediatric Epilepsy Side Effect Questionnaire (PESQ) at clinic visits and any other ADRs reported by parents were also recorded. Causality, severity and avoidability assessments were done. Results: The mean age was 10.5 ± 3.6 years. A total of 139 ADRs occurred in 97 patients. One hundred and nine ADRs were reported by use of PESQ, in addition, 30 ADRs were reported by parents. Poor school result (33.8%) was the commonest ADR. Valproate (61.9%) was the main drug causing ADRs. Valproate, when used in polytherapy, was associated with more number of children experiencing ADRs (72.2%). The most common add on drug was clobazam (42.3%). Children with poorly controlled epilepsy were associated with more ADRs. Causality assessment revealed that 91.3% of the ADRs were probable. Most (94.9%) ADRs were of ‘mild’ category and 95.7% were probably preventable. Treatment was discontinued only in 6 patients of phenytoin toxicity.R Conclusion: Cognitive and neurological problems were the most common ADRs seen in children with epilepsy. Polytherapy significantly increases the likelihood of ADRs in children.
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Steinhausen, H.-C., G. Lösche, S. Koch, and H. Helge. "The psychological development of children of epileptic parents. I. Study design and comparative findings." Acta Paediatrica 83, no. 9 (1994): 955–60. http://dx.doi.org/10.1111/j.1651-2227.1994.tb13180.x.

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Jovanovic, Svetlana, Ivanka Gajic, and Vlada Radivojevic. "Risk factors for oral changes in children with epilepsy: Informative article." Serbian Dental Journal 56, no. 1 (2009): 33–39. http://dx.doi.org/10.2298/sgs0901033j.

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Epilepsy is the most common neurological disorder in people of all ages. Based on the data regarding the prevalence of epilepsy in other countries, about 12,000 individuals under the age of 18 are estimated to suffer from active epilepsy. Children with epilepsy are a high risk group for oral diseases primarily due to psychiatric and psycho-social consequences of the primary disorder as well as the adverse effects of anti-epileptic therapy. Due to the primary disorder, children with epilepsy have reduced motivation for a number of activities, reduced mental and physical abilities, neglected social contacts, more difficult adoption of knowledge, skills, positive attitudes and behavior as well as general and oral healthcare. In children with epilepsy, there is an additional risk for oral diseases due to the adverse effects of anti-epileptic therapy such as gingival hyperplasia. Studies in other countries and in Serbia showed higher prevalence and frequency of oral diseases compared to the control group of healthy children of the same age. This paper emphasizes the need for dental educational work with children with epilepsy and their parents as well as doctors who treat the primary disorder.
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Wolf, L., and B. Goldberg. "Autistic Children Grow Up: An Eight to Twenty-Four Year Follow-Up Study." Canadian Journal of Psychiatry 31, no. 6 (1986): 550–56. http://dx.doi.org/10.1177/070674378603100613.

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Eighty questionnaires were sent to parents and/or caregivers of autistic persons diagnosed between 1960–73 at CPRI, a regional assessment and treatment centre. The objective was to determine their present place of residence, functioning ability, language development, program involvement, and seizure activity. The results of this study support evidence that more than 50 percent require long-term institutional care; almost one-third suffer epileptic seizures; there is a persistence of symptoms and difficulty in gaining useful speech; few live independently or are capable of employment.
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Mohamed, Hiam. "Knowledge's and Attitude of Parents about Epileptic Disease among Their Children at Assuit University Hospital." Assiut Scientific Nursing Journal 4, no. 7 (2016): 104–14. http://dx.doi.org/10.21608/asnj.2016.58647.

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Gay, Patricia E., Guy F. Mecham, Jason S. Coskey, Toni Sadler, and Joel A. Thompson. "Behavioral Effects of Felbamate in Childhood Epileptic Encephalopathy (Lennox-Gastaut Syndrome)." Psychological Reports 77, no. 3_suppl (1995): 1208–10. http://dx.doi.org/10.2466/pr0.1995.77.3f.1208.

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The behavioral effects of felbamate were assessed in 20 persons (ages 2 to 19 years) who were participating in a compassionate plea protocol for children with Lennox-Gastaut syndrome. Parents completed a questionnaire concerning aspects of behavioral change once all medications were in a constant regimen. Significant improvements were suggested in social functioning, intellectual functioning, motor functioning, attention and concentration, alertness, initiative, variability In performance, and memory. There was a tendency for these effects to reverse when the drug was discontinued.
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Maia Filho, Heber de Souza, Marleide da Mota Gomes, and Lucia Maria da Costa Fontenelle. "Development and validation of a health related quality of life questionnaire for Brazilian children with epilepsy: preliminary findings." Arquivos de Neuro-Psiquiatria 63, no. 2b (2005): 389–94. http://dx.doi.org/10.1590/s0004-282x2005000300004.

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PURPOSE: To construct a multidimensional questionnaire that analyses the epileptic child quality of life from the parental point of view. METHOD: The pilot questionnaire was composed of 157 questions distributed in several dimensions. Fifty-one epileptic children's parents answered the questionnaire. The instrument was tested in its diverse properties: frequency of endorsement, homogeneity (Cronbach alpha), criterion and face validity, and later it was reduced. RESULTS: Endorsement frequency excluded 65 questions that did not attain a minimum of 5% response per item. Cronbach alpha was as follows: physical (0.93), psychological (0.91), social (0.91), familiar (0.70), cognitive (0.92), medical (0.30) and economical (0.37). Patient groups, in relation to seizure control, significantly differed only in physical domain and total score, although there was a trend to differences in other domains. The final questionnaire (QVCE50) has 50 items, with good homogeneity in the physical, psychological and cognitive domains. CONCLUSION: QVCE-50 is a promissing Brazilian HRQL questionnaire for children with epilepsy.It needs to be applied in a larger population to confirm its psychometric properties.
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Pathan, Habib G., Abdul Naseer Abdul Bari, and Prashant R. Kokiwar. "A study of etiology and characteristics of febrile convulsions and epilepsy among children." International Journal of Contemporary Pediatrics 4, no. 6 (2017): 2093. http://dx.doi.org/10.18203/2349-3291.ijcp20174738.

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Background: Globally in all parts of the world, epilepsy is the most common neurological disorder of chronic nature. Seizures among children are common and challenging for the pediatrician. The objective of this study was to study etiology and characteristics of febrile convulsions and epilepsy among childrenMethods: The present study was a prospective observational study conducted in a tertiary care centre among subjects who had seizures. Subjects were recruited from pediatric ward, consecutively hospitalization of pediatric patients, and of either sex who presented with history of seizures. The data included demographic details and history.Results: Total febrile seizures were 25.46% and overall incidence was around 2.57%. Preponderance of male constituting 62.65% over female 37.35% was observed. Most of the febrile seizures were simple type. Fever due to upper respiratory tract infection was commonest cause. It was not associated with any complications. Epileptic cases were 38.65% of total cases and overall incidence was 3.9%. In this group also, there was male preponderance. It increased with age. Commonest presentations of epileptic seizures were generalized in 67.46%. Most common cause of acute symptomatic seizures was viral encephalitis (28.34%). Numbers of deaths were more in acute symptomatic. Conclusions: As there were no morbidity and mortality with febrile seizures so it is possible to explain the benign nature of febrile seizures to their parents. Acute symptomatic seizures are to be identified and treated immediately.
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Azmy, Ashraf, Eman Mones Abushady, and Mones M. Abu Shady. "Online Health Survey on Epileptic Children during Coronavirus Disease-2019 Pandemic." Open Access Macedonian Journal of Medical Sciences 9, B (2021): 392–97. http://dx.doi.org/10.3889/oamjms.2021.6128.

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BACKGROUND: Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2, and the outbreak is now rapidly spreading globally. The current administrative measures of lock-down, social distancing, and self-isolation are intended at reducing the spread of the viral infection, minimizing contacts between potentially infected individuals and healthy subjects. However, they can complicate the management of children with neurological illnesses by instigating or worsening concomitant anxiety and depression, hindering the interactions with physicians, and leading to shortages or inconsistent supply of medicines. OBJECTIVE: The current study aims to provide information on the medical care and wellbeing of children with epilepsy during COVID-19 pandemic and provide the best possible care for those children while avoiding visits to urgent care facilities and hospitalizations during the pandemic. METHODS: The current study was an observational cross-section survey study. One hundred twenty children with epilepsy following in the epilepsy clinic of Medical Research Center of Excellence, and epilepsy clinic at Neurology Department, Faculty of Medicine, Ain Shams University aged above 4 years were recruited. The authors designed a 22-items questionnaire to address impact of COVID-19 crisis on the care, seizure outcome, behavior of children, and concerns of their parents. The study was conducted during the period from May 2020 to November 2020. RESULTS: The study included 120 epileptic children, 47 males and 73 females, with age ranged from 4 to 17 years with mean age 8.34 ± 3.877 years. Before COVID pandemic, 18.3% of care providers had worries about epilepsy, while during the pandemic, 78.3% of them had the same worries. Twenty percent of the studied patients showed worsened sleep during the pandemic. Medical follow-up difficulties and drug access difficulties were found in 18.3% and 50% of the patients, respectively, during the pandemic. Child anxiety was 20% before the pandemic and 97.5% during the pandemic. Of the care providers, 95.8% were worried about their children of getting COVID 19. Thirty percent showed a need for psychological support, 76.7% for medical support, and 75% for information support about epilepsy. Medical support by phone or online during the pandemic was accepted by 80.8% of the caregivers. The study also showed that epileptic children with age ≤12 years needed more psychological support than those >12 years. All children without anxiety before the COVID-19 pandemic had anxiety during COVID-19 pandemic, while 87.5% of those with anxiety before COVID still had anxiety during the pandemic, signifying that COVID 19 pandemic increased the anxiety of the epileptic children significantly. CONCLUSION: The present study found no increase in seizure exacerbation during the outbreak of COVID-19. During the pandemic, worries of the care providers about progression of the frequency of seizure and epileptic children anxiety increased significantly. Physicians should offer health care facilities including medications and information as much as possible at home to keep children with epilepsy in good psychological and mental status as well as minimizing of risk of seizure exacerbation through adherence. Effective telemedicine tools will prove useful for the long-term management of these patients.
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Jaroenying, Rasintra, Pluemkamon Rattanarat, and Piradee Suwanpakdee. "629 Sleep problems among children and adolescents with epilepsy in Thailand: single-center cross-sectional study." Sleep 44, Supplement_2 (2021): A247. http://dx.doi.org/10.1093/sleep/zsab072.627.

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Abstract Introduction Sleep problems are common in pediatric epilepsy and may influence seizure control, daytime performance, and quality of life. The aim of this study was to investigate parent-reported and self-reported sleep problems in a sample of children and adolescents with epilepsy in Thailand. Methods Epileptic children age 1–18 years and their parents in epilepsy clinic completed the Phramongkutklao Hospital Sleep disorders center Questionnaire, Sleep Related Breathing Disorder- Pediatric Sleep Questionnaire (SRBD-PSQ) Results A total of 59 participants with the mean age of 10.8 years completed the questionnaires. The most common sleep complaint was a disorder of maintaining sleep 36 (61.01%). Several sleep manifestations were detected including disorder of initiating sleep 14 (23.7%), snoring 29 (49.2%), leg kicking 16 (27.1%), sleep talking 19 (32.2%), sleep walking 4 (6.7%), teeth gliding 18 (30.5%), nightmares 15 (25%), night terrors 8 (13.5%) and nocturnal enuresis 16 (27.1%). The frequency of sleep disordered breathing problems (SRBD-PSQ >0.33) was 33.9%. Conclusion The prevalence of sleep problems among children with epilepsy in Thailand is high. Therefore, a highlighting should be given to address sleep in children and adolescents with epilepsy. Further studies are needed to evaluate the effects of antiepileptic drugs, type of seizure or associated factors on sleep disruption in this population. Support (if any) None
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Kabasakal, Esma, Hilal Özcebe, and Umut Arslan. "Are the health needs of children with disabilities being met at primary schools?" Journal of Intellectual Disabilities 24, no. 4 (2019): 448–58. http://dx.doi.org/10.1177/1744629518818657.

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The aim of this study was to provide current information about the health profile and needs of mainstreamed primary school children with disabilities and special educational needs during their school hours. The Study population is composed of students with special educational needs and disabilities attending mainstream primary schools located in three selected Turkish districts with low, moderate, and high socioeconomic status and literacy rates separately. Parents of 404 students from 72 primary schools constituted the research sample. The study showed that 13.4% of the students with disabilities had chronic illnesses and 8.9% had health problems requiring access to emergency medical care when the condition recurs (such as epileptic seizures, fainting, or falling). Of the students with disabilities, 39.9% usually or sometimes needed medical care during school hours in the previous week. Health needs of nearly half of the students with disabilities were met at school. Special health needs and risks of children with disabilities also continue at school along with other possible health concerns.
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Fonseca, Lineu Corrêa, Glória Maria A. S. Tedrus, Elisabeth Marinelli de Camargo Pacheco, Marcela Fernanda Berretta, Amanda Augusta Campregher, and Débora Macedo Costa. "Benign childhood epilepsy with centro-temporal spikes: correlation between clinical, cognitive and EEG aspects." Arquivos de Neuro-Psiquiatria 65, no. 3a (2007): 569–75. http://dx.doi.org/10.1590/s0004-282x2007000400004.

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Benign childhood epilepsy with centro-temporal spikes (BECTS) is a form of epilepsy with no demonstrable anatomical lesion showing spontaneous seizure remission. During the active phase of the disease the children may show cognitive deficits. The objective of this study was to assess, in children with BECTS, the relationship between clinical-EEG aspects and performance in the school performance test (SPT), Raven's progressive matrixes test and the Wechsler Intelligence Scale for Children (WISC-III). Forty-two 7 to 11 year old children were included and the following tests carried out: anamnesis, neurological examination, electroencephalogram (EEG), SPT, Raven's test and WISC-III. The children with BECTS had normal IQ values but showed inferior performance in the SPT more frequently than "healthy" children, paired with respect to age and maternal scholastic level. There was moderate positive correlation between WISC-III results and the age when the seizures started and the educational level of the parents. On the other hand, aspects linked to the epileptic nature of BECTS, such as the number of seizures, time since last seizure and the number and lateralization of the centro-temporal spikes on the EEG, showed no correlation with the neuropsychological tests.
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Ros-Sanjuán, Ángela, Sara Iglesias-Moroño, Bienvenido Ros-López, Francisca Rius-Díaz, Andrea Delgado-Babiano, and Miguel Ángel Arráez-Sánchez. "Quality of life in children with hydrocephalus treated with endoscopic third ventriculostomy." Journal of Neurosurgery: Pediatrics 27, no. 5 (2021): 503–10. http://dx.doi.org/10.3171/2020.8.peds20384.

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OBJECTIVE The objectives of this study were to determine the quality of life of a pediatric cohort with hydrocephalus treated by endoscopic third ventriculostomy (ETV), using the Hydrocephalus Outcome Questionnaire–Spanish version (HOQ-Sv), and study the clinical and radiological factors associated with a better or worse functional status. METHODS This cross-sectional study was undertaken between September 2018 and December 2019. It comprised a series of 40 patients ranging from 5 to 18 years old with hydrocephalus treated by ETV. ETV was considered to be successful if there was no need for surgery for the treatment of hydrocephalus after a minimum follow-up of 6 months. The clinical variables included gender, age at hydrocephalus diagnosis, age at the time of ETV, age at completion of the questionnaire, etiology and type of hydrocephalus (communicating or not), prior shunt, repeat ETV, number of neurosurgical procedures, number of epileptic seizures, presenting signs, and follow-up duration until last office revision. The radiological variables were the Evans Index and the pre- and posttreatment frontooccipital horn ratio. An analysis was conducted of the association between all these variables and the various dimensions on the HOQ-Sv, completed by the parents of the patients via telephone or in the outpatient offices. RESULTS The mean age of the children at ETV was 7 years (range 7–194 months), and on completing the questionnaire was 12 years (range 60–216 months). The mean HOQ scores were as follows: overall 0.82, physical domain 0.86, social-emotional (SE) domain 0.84, cognitive domain 0.75, and utility score 0.90. A history of epileptic crises was a predictive factor for a worse score overall and in the SE and cognitive domains. Factors related to a worse score in the physical domain were a previous shunt, the number of procedures, and the etiology and type of hydrocephalus. The mean follow-up duration from ETV to the last office visit was 5 years (64.5 months). No association was found between the degree of ventricular reduction and the quality of life. CONCLUSIONS The factors related to a worse score in the different dimensions of the HOQ were a history of epileptic seizures, the number of procedures, communicating hydrocephalus, and having had a previous valve. No association was found between the reduction in ventricular size and the quality of life as measured on the HOQ-Sv.
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Carmassi, C., M. Corsi, C. Gesi, et al. "Post-traumatic Stress Spectrum and Adult Autism Subthreshold Spectrum in Parents of Children with Epilepsy: Correlations and Gender Differences." European Psychiatry 41, S1 (2017): S721—S722. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1305.

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IntroductionData that assess the co-morbidity between post-traumatic stress symptoms and autism spectrum are scarce. Nevertheless, some authors suggested that subjects with autism spectrum disorder (ASD), due to their difficulty in understanding the codes of communication, empathy, expression, are lower resilience to traumas.ObjectivesThe aim of this study was to explore in a sample of parents of children with epilepsy, the presence of correlations between the symptoms of post-traumatic stress and adult autism subthreshold spectrum.MethodsSeventy-seven parents completed the Trauma and Loss Spectrum Self-Report (TALS-SR), specifically modified for one's son epileptic disease, and 72 parents completed the AdAS Spectrum (Adult Autism subthreshold Spectrum).ResultsEight subjects (11.1%) presented a total score ≥45 at the AdAS Spectrum, corresponding to the satisfaction of a symptomatic ASD criteria and indicative of the Adult Autism Spectrum subthreshold. More specifically, a total score ≥45 was found in 7 (15.9%) of mothers and 1 (3.6%) of the fathers, with no statistically significant differences between the two groups (P = 0.139).Noteworthy correlations between TALS and AdAS, emerged only in the subgroup of the fathers. In particular, a relevant number of moderate to good correlations emerged between the Domain II (reactions to the events of loss) of the TALS-SR and the AdAS Domain III (non verbal communication), Domain VI (restricted interests and ruminations) and total score.ConclusionsResults indicate that this peculiar psychopathological model could lead to increased vulnerability to effects of the trauma, in particular in male.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Buffo, Thais Helena, Marilisa M. Guerreiro, Peter Tai, and Maria Augusta Montenegro. "Seizure related accidents and injuries in childhood." Arquivos de Neuro-Psiquiatria 66, no. 3a (2008): 458–61. http://dx.doi.org/10.1590/s0004-282x2008000400003.

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Several studies show that the risk of accidents involving patients with epilepsy is much higher compared to the general population. The objective of this study was to identify the frequency and type of seizure related injuries in children diagnosed with epilepsy. In addition we also assessed possible risk factors associated with this seizure related accidents in childhood. This study was conducted at the pediatric epilepsy clinic of Unicamp, from January 2005 to August 2006. We evaluated 100 consecutive children with epilepsy. Parents were interviewed by one of the authors using a structured questionnaire that included questions about seizure related accidents and related injuries. Forty-four patients reported seizure related accidents. Eighteen patients needed medical assistance at an emergency room due the severity of their seizure related accident. Forty patients reported having a seizure related accident prevented by a bystander. Another 14 patients reported avoiding a seizure related accident by luck alone. Contusions and lacerations were the most common type of lesion associated with seizures. Patients with symptomatic/probable symptomatic epilepsy and those using higher numbers of anti-epileptic drugs (AEDs) were at greater risk for seizure related accidents (p<0.05). We conclude that patients with symptomatic/probable symptomatic epilepsy and on multiple AEDs are at increased risk of seizure related accidents. Parents and caretakers should be even more cautious about risk of injury in such patients.
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Babajić, Mirela, Emira Švraka, and Dijana Avdić. "Frequency of joined disabilities of children with cerebral palsy in Tuzla canton." Journal of Health Sciences 3, no. 3 (2013): 222–26. http://dx.doi.org/10.17532/jhsci.2013.111.

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Introduction: Cerebral palsy (CP) connotes a group of non-progressive, but often variable symptoms of motor impairment of movement and posture, as well as other impairments which are a consequenceof anomalies or brain impairment in different phases of its development. CP is a pathological condition characterised in the fi rst place by motor function impairment to which other disorders such as: visual andhearing impairment, intellectual defi cit, emotional problems, behaviour disorder, speech disorder, epileptic seizure and similar can join. The aim of this study is to determine frequency of joined disabilities ofchildren with cerebral palsy in Tuzla Canton.Methods: The research covers a total sample of 48 examinees, chronological age from 2-19 years, in Tuzla Canton. Research instrument was a Structural Questionnaire for the parents of children and adolescentswith cerebral palsy. Research data were processed by nonparametric statistics method. Basic statistical parameters of frequency and percentages were calculated, and tabular presentation was made.Results: After classification of examinees as per frequency of joined disabilities was done, work results have shown that speech impairment occurred with 35.4 % of children, visual impairment 33.3 %, epilepsy29.3 %, whereas hearing impairment occurred with 2 % of children.Conclusion: In research of frequency of joined disabilities of children with cerebral palsy in Tuzla Canton, most expressed are speech and visual disorders with children, then epilepsy, whereas a small percentageof children are with hearing disorder.
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GUERREIRO, MARILISA M., MARIA LUIZA G. MANREZA, ANNA ELISA SCOTONI, et al. "A pilot study of topiramate in children with Lennox-Gastaut syndrome." Arquivos de Neuro-Psiquiatria 57, no. 2A (1999): 167–75. http://dx.doi.org/10.1590/s0004-282x1999000200001.

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We conducted an open, add-on study with topiramate (TPM) as adjunctive therapy in Lennox-Gastaut syndrome (LGS), to assess the long-term efficacy and safety and to evaluate quality of life (QL) measurements in the chronic use of TPM. We studied 19 patients (11 male; age ranging from 4 to 14 years) with uncontrolled seizures receiving 2-3 anti-epileptic drugs. Patients were followed up to 36 months of treatment. A questionnaire was used to query parents about QL. Seven patients completed the study at 36 months and seizure frequency was reduced > 75% in 4, and < 50% in 3 patients. Two children became seizure free for more than 24 months. Most side effects were CNS related, with the most frequent being somnolence and anorexia. These were generally transient. One patient dropped-out due to powder in the urine. None of the patients required hospitalization. At 36 months, patients' alertness (2/7), interaction with environment (5/7), ability to perform daily activities (5/7), and verbal performance (6/7) improved on TPM. We conclude that TPM may be useful as adjunctive therapy in the treatment of LGS. The efficacy of TPM was maintained in long-term treatment in more than 40% of patients, long term safety was confirmed and QL improved on TPM.
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Knezevic-Pogancev, Marija. "Risk of vaccination in children with epilepsy." Medical review 63, no. 9-10 (2010): 696–700. http://dx.doi.org/10.2298/mpns1010696k.

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Introduction. The central nervous system, previously considered as 'immune privileged', does exhibit features of inflammation in response to injury, infection or disease. We do not know its reactions on immunization. We do not know how common febrile seizures after vaccination are and if there are subgroups of children at higher risk. What is the long term outcome for children who had a febrile seizure after vaccination? Can the vaccine be a direct cause of a condition called an epileptic encephalopathy, where seizures damage the brain with the resulting epilepsy? Discussion and Conclusion. It should not be forgotten that 'benign infective childhood diseases' can, and do, kill, and that vaccines are a public health intervention saving many millions of lives around the world. Parents as well as doctors have fear: whether vaccinations can cause convulsions, epilepsy or encephalopathy. Large studies of this issue have produced conflicting results, although the recent consensus is that the risk of vaccine-induced epilepsy and or encephalopathy, if it exists at all, is extremely low. It is necessary to establish a proposed immunization program for children at neurologically high risk and for children with epilepsy to protect them and the whole population from infectious diseases, children from immunization adverse events, and avoid possibilities of legal trial. It is necessary to know everything about the risks and benefits of immunizations for each child. For each child, the risks of the disease, and its squeal, must be compared with the vaccine's protective efficacy and potential adverse reactions. Vaccination is given preference in nearly all children with epilepsy.
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Mikhailichenko, Natalia V., Viacheslav Kulagin, Takuma Shio, Jun Takanari, and James Cheng-Chung Wei. "An open label trial of a standardized extract of cultured Lentinula edodes mycelia (ECLM) in children with refractory epilepsy." Functional Foods in Health and Disease 9, no. 3 (2019): 145. http://dx.doi.org/10.31989/ffhd.v9i3.570.

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Objectives: This open-label trial was performed to assess the immune markers in a cohort of children with refractory epilepsy in order to identify diagnostic and therapeutic markers and to also investigate the effect of an immunologically active supplement derived from mushroom, a standardized extract of cultured Lentinula edodes mycelia (ECLM), on the clinical status and on the immunological markers in the subjects.Methods: Eighteen pediatric patients diagnosed with refractory epilepsy in which antiepileptic therapy was not effective were enrolled. All subjects were also treated with anticonvulsant medications for their seizures. Patients were administered 0.6 g/day (< 3 years old) or 1.2 g/day (> 3 years old) of ECLM (fine-granule equivalent) orally for one month. Immunological markers were assessed at baseline and after one month. Video electroencephalogram (EEG) was taken twice, once before the trials and once at the end of ECLM treatment. Seizure frequency and behavioral symptoms were measured by a questionnaire survey of the parents. A two-month follow-up was also performed for surveillance of secondary infections.Results: The subjects treated with ECLM showed significant elevation of several immune parameters including immunoglobulin G (IgG), CD3, CD4, and CD20 lymphocytes, and phagocytic index. Six of the 18 children on stable anticonvulsant drugs had fewer seizures reported during the ECLM treatment. The ECLM-treated patients also had less sharp and spike activity in the EEG measurement. At the two-month follow-up, the ECLM-treated subjects had developed fewer infections and viral syndromes compared to their condition before the trial. The children’s family reported other subjective behavioral improvements, leading to improved quality of life (QOL). Conclusion: ECLM administration to the pediatric patients with refractory epilepsy contributed to improvement of epileptic manifestation and decrease of epileptic seizure, possibly by suppressing the reactivation of herpes virus, as well as improvement of QOL. In addition, it was demonstrated that ECLM is a safe supplement for infants and children. Keywords: ECLM, epilepsy, children, pediatric, mushroom
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Lösche, G., H.-C. Steinhausen, S. Koch, and H. Helge. "The psychological development of children of epileptic parents. II. The differential impact of intrauterine exposure to anticonvulsant drugs and further influential factors." Acta Paediatrica 83, no. 9 (1994): 961–66. http://dx.doi.org/10.1111/j.1651-2227.1994.tb13181.x.

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Barton, Madelyn, Marie-Noëlle Simard, Sandra Reiter-Campeau, et al. "VALIDITY OF PARENT-COMPLETED DEVELOPMENTAL SCREENING IN CHILDREN WITH NEW-ONSET EPILEPSY BELOW THE AGE OF 3." Paediatrics & Child Health 23, suppl_1 (2018): e51-e52. http://dx.doi.org/10.1093/pch/pxy054.131.

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Abstract BACKGROUND Infants with childhood-onset epilepsies, including epileptic encephalopathies, are at high risk of developmental challenges such as motor and language delays. There has been a growing focus on developmental screening instruments due to the association between delayed development and long-term adverse outcomes, including negative impacts on health-related quality of life, school achievement and social participation. Therefore, children with developmental delays should be referred as early as possible to rehabilitation services such as occupational, physical, or speech therapy. Developmental screening using standardized tools is recommended in order to identify the high-risk children that require additional developmental assessments. The Ages and Stages Questionnaires (ASQ), a parent-completed developmental screening tool, is one of the more cited and recommended developmental screening tools. However, its utility in children with early-onset epilepsy has yet to be validated. OBJECTIVES This study aimed to determine the validity of the ASQ for identifying children with new-onset epilepsy who require further professional developmental rehabilitation. DESIGN/METHODS Fifty infants (25 males) with seizure onset under 3 years of age were prospectively recruited. Parents completed the ASQ-3 before the first clinic appointment. The ASQ-3 evaluates 5 domains of development. An ASQ score below 2 standard deviations (SD) on any one of the domains was considered abnormal. Once completed, all infants were evaluated by a multidisciplinary team including neurologists, occupational therapists, and physical therapists to determine if they should be referred for further rehabilitation interventions. Accuracy of the ASQ was calculated in terms of sensibility, specificity, positive predictive value (PPV) and negative predictive value (NPV). RESULTS Mean age at the initial evaluation was 13.1 months (SD=8.22). Among the 50 infants, 36 (72%) received a score <-2 SD in at least one domain of the ASQ and 43 (86%) were referred for further rehabilitation services after the multidisciplinary assessment. The ASQ had a sensitivity of 81%, a specificity of 71%, a PPV of 93% and a NPV of 36% in identifying children with new-onset epilepsy who would require further rehabilitation services. CONCLUSION The ASQ, a well-known parent-completed developmental screening tool, when abnormal shows adequate validity for the identification of children with early-onset epilepsy who require developmental assessments and interventions by rehabilitation professionals. Our results also provide further evidence that development delay is the rule rather than the exception in infants with new onset epilepsy.
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A., Amar Jayanthi. "Pedigree Analysis of Idiopathic Epilepsy In Children of South Kerala." National Journal of Clinical Anatomy 01, no. 01 (2012): 024–29. http://dx.doi.org/10.1055/s-0039-3401652.

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Abstract Background and aims: Epilepsy is a major health problem in infancy and childhood. Genetic factors are implicated in the etiology of epilepsy. A familial susceptibility to seizures have been recognized but the exact mode of inheritance remains unclear. The chief objective was to determine the inheritance pattern and to correlate its prevalence among closer relatives on the basis of sex, degree of relationship and age of onset of the disease. Materials and methods: A pedigree analysis of 100 clinically diagnosed children with idiopathic epilepsy seen between 1994 and 1997 at the Paediatric Neurology Clinic of Government Medical College, Thiruvananthapuram was done. The mode of inheritance was tested according to the genetic hypothesis of segregation analysis. Results: Positive family history was observed in 49% of the probands. A high proportion of probands with an early onset of disease showed involvement of family members and a significant sex predisposition for females was obtained. Relatives of female probands were affected more than those of males. Mothers were found to transmit the disease to offsprings more than the epileptic fathers. Conclusion: The results of pedigree analysis supported the hypothesis of an autosomal multifactorial mode of inheritance, with 86% heritability and a lower threshold for the disease to manifest. The application of modern genetic principles like identification of susceptibility gene to epilepsy, linkage and association studies would advance our understanding of the etiology of seizure disorders. Genetic factors may play a major role in the predisposition of relatives to epilepsy in families of probands with idiopathic epilepsy. The present study may aid in the genetic counselling of parents with epilepsy.
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Helmy, Farihan. "Siblings with autism, mental retardation, and convulsions in tuberos sclerosis: A case report." International Journal of Growth and Development 1, no. 1 (2017): 24. http://dx.doi.org/10.25081/ijgd.2017.v1i1.25.

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A 3 years old female patient born of consanguineous parents presented to the (development and behavioral clinic) inTaif children hospital, Western Saudai Arabia , her mother complained that her daughter had speech delay, no eye to eye contact, and was performing stereotyped behaviors (hand flapping).The girl developed convulsions at the age of3 months and was on anticonvulsant medication since that age, her convulsions were controlled on anti-epileptic treatment .Family history revealed that the girl had a male sibling 6 years old who developed convulsions at the age of 4 months and is on antiepileptic medications, the boy suffered also from speech delay, absent social interaction, and repetitive behaviors. On examination the girl had characteristic features of angio-fibromas, hypo-pigmented macules on the trunk and legs, and moreover the boy had similar skin features plus hypo-pigmented tufts of hair. Both cases were diagnosed as Autistic spectrum disorder, tuberous sclerosis, and mental retardation. The family needed genetic counseling, while both cases needed as soon as possible behavioral and educational strategies.
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Nasution, Gita Tiara Dewi, Siti Aminah Sobana, and Leonardo Lubis. "Karakteristik anak epilepsi di Sekolah Luar Biasa Negeri (SLBN) Cileunyi Bandung tahun 2018." Bali Anatomy Journal 3, no. 1 (2020): 1–10. http://dx.doi.org/10.36675/baj.v3i1.36.

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Background: Research regarding characteristics of epileptic children in special needs school in Indonesia had never been conducted. Aim: This research aims to provide education to the parents about the characteristics and to provide new reference for further researches. Methods: This descriptive cross-sectional research was conducted in September – November 2018 using a questionnaire inquiring about demographic, socio-economic condition, clinical picture, prenatal, perinatal and postnatal factors. The subjects of this research are class C students in public special needs school Cileunyi Bandung. Sample size was calculated using a categorical descriptive formula and was determined to be 13 subjects. Result and Conclusion: The most prevalent characteristics are male (8), age ≥16 year old (5), elementary school (7), tonic-clonic seizure type (7), present history of repeated seizure (11), one type of seizure (6), onset of seizure in newborn age (7), duration of seizure <15 minutes (9), term delivery (9), birth weight ≥ 2500 grams (9), spontaneous vaginal delivery (10), and present history of febrile seizure (7).
 Latar Belakang: Penelitian mengenai karakteristik anak dengan epilepsi di Sekolah Luar Biasa (SLB) di Indonesia belum pernah dilakukan. Tujuan: Penelitian ini bertujuan memberikan wawasan kepada orang tua mengenai karakteristik anak dengan epilepsi di SLB serta dapat menjadi referensi data untuk perkembangan ilmu pengetahuan dan penelitian selanjutnya. Metode: Penelitian ini merupakan studi deskriptif dengan desain potong lintang yang dilakukan pada bulan September - November 2018 menggunakan kuesioner yang berisi pertanyaan mengenai karakteristik demografis, sosial ekonomi, gambaran klinis, faktor prenatal, perinatal, dan postnatal. Subjek penelitian adalah siswa/siswi kelas C SLB Negeri Cileunyi Bandung. Penentuan jumlah sampel minimum menggunakan formula deskriptif kategorik dan didapatkan 13 subjek penelitian. Hasil dan Simpulan: Karakteristik yang paling banyak ditemukan adalah jenis kelamin laki-laki (8), usia ≥ 16 tahun (5), tingkat pendidikan Sekolah Dasar (7), jenis kejang tonik-klonik umum (7), terdapat riwayat kejang berulang (11), satu tipe kejang (6), onset kejang terjadi pada usia bayi (7), durasi kejang < 15 menit (9), usia persalinan cukup bulan ((9), berat badan lahir ≥ 2500 gram (9), persalinan secara spontan melalui vagina (10), dan memiliki riwayat kejang demam (7).
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Kitamoto, Ikuko, Toru Kurokawa, Shigeru Tomita, Yasufumi Maeda, Kanji Sakamoto, and Kohji Ueda. "Child-parent relationships in the care of epileptic children." Brain and Development 10, no. 1 (1988): 36–40. http://dx.doi.org/10.1016/s0387-7604(88)80043-3.

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Ajeetha, Rahumath, Anand Ramakrishnan, and Benjamin Sagayaraj. "Camphor induced status epilepticus: a case report." International Journal of Contemporary Pediatrics 5, no. 3 (2018): 1140. http://dx.doi.org/10.18203/2349-3291.ijcp20181559.

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Camphor is very toxic compound, which can be fatal for infants and children even if ingested in very small doses. Around 3-5 ml of 20% camphor oil or >30mg/Kg is a potentially lethal dose. Camphor is used very frequently for house hold purposes. The chances of accidental ingestion by children are high particularly in toddlers. Here author report 2 years old previously well child brought with status epilepticus with no apparent trigger. Child required benzodiazipine, phenytoin and levetiracetam loading for seizure control and was ventilated. Complete evaluation for seizure cause was planned post stabilization, but during intubation camphor odour was noticed and parents accepted a possibility of camphor ingestion. Hence seizure was attributed to camphor toxicity. Further evaluation was withheld. Child had no seizure recurrence and AED was stopped prior to discharge after documenting normal neurological examination and EEG. This case highlights the need for considering camphor poisoning as a cause of status epilepticus in the toddler age group and importance of proper enquiry about possible exposure and complete examination including odour in all cases of unprovoked seizures in children which can help us avoid unnecessary investigations searching for the cause of status epilepticus.
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44

Burrows, Kim, and Jennifer Ann Williams. "THC intoxication in a 16-month-old child." Paediatrics & Child Health 24, no. 5 (2019): 299–300. http://dx.doi.org/10.1093/pch/pxz015.

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Abstract A 16-month-old previously healthy child with normal development presented with decreased level of consciousness, apneas, and seizure requiring intubation and treatment for status epilepticus. Investigations revealed no evidence of infection or trauma, normal head CT scan, and urine positive for tetrahydrocannabinol (THC) and negative for other substances. This report outlines the clinical presentation, approach to treatment, and potential seriousness of THC intoxication in young children. Mandatory reporting and monitoring of THC intoxication in children is recommended. The need for effective education of parents about the risks of unintentional THC poisoning and measures to safeguard young children is discussed.
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45

Raffaele, Martin. "A Qualitative Study Exploring Family Life in Men Following Neurosurgery for Adult Onset Epileptic Seizures." Australian Journal of Rehabilitation Counselling 24, no. 2 (2018): 55–66. http://dx.doi.org/10.1017/jrc.2018.11.

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This study explored family relationship dynamics of men with Adult Onset Epileptic Seizures (AOES) following an elective lobectomy procedure to address their frequent seizure activity. Informants were five Australian men with history of adult-onset epilepsy for which they received neurosurgery (aged 34–59 years). Thematic analysis following semi-structured interviews yielded three themes: role marginalization, role dependency and role enmeshment. All the men reported significant role marginalization in not being consulted about everyday life activities. They also reported to experience decisional role shifting towards their spouses or partners and children post-surgery. Their family role enmeshment experiences included being perceived by spouses or partners as adult–children and by their children as a parent–child. However, some of the men were accepting of these role definitions and to add rather than take away from their health-related quality of life.
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46

Shevchuk, V. "PSYCHOLOGICAL DETERMINANTS OF PERSONAL CHANGES IN PARENTS OF CHILDREN WITH DEVELOPMENTAL DISABILITIES." Psychology and Personality, no. 1 (May 20, 2021): 57–71. http://dx.doi.org/10.33989/2226-4078.2021.1.227192.

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The article is devoted to the description of scientific research and theoretical generalization of modern ideas about the influence of psychological factors on personal changes in parents raising children with disabilities. The study outlines the urgency of this problem, as the number of such families is constantly growing and the fact of birth of a child with mental and physical disabilities can become a trauma for parents, which manifests itself in the form of despair, anger, irritability and more. The study of the personal characteristics of parents raising children with disabilities is important for the development of effective methods and programs of psychological support for such families. Common features of parents of children with disabilities are sensitivity, hypersocialization and protective behavior, they are characterized by feelings of isolation, depression, weakness and the need for compassion of others, and the main psychological reactions to a child with developmental disabilities are shock, denial, aggression, depression and acceptance. Parents with high levels of subjective stress have fewer adaptive resources to their child's special needs. In general, parents of children with disabilities are divided into neurotic, authoritarian and psychosomatic types (according to V. Tkachova) and schizophrenic, epileptoid, steroid and cycloid psychotypes (according to I. Ryzhenko). 
 The concept of experiencing heavy loss is highlighted by E. Kubler-Ross, OV Gnezdylov, K. Lucas and the constitutional-continuum concept of IV Boev and OO Akhverdov. In general, personality-typological constitutional variability determines the transformation of personality in the ranges of psychological norm-accentuation-borderline abnormal personality (MAO) – pathological mental constitution (psychopathy). The severity of variational personal variability, which is defined constitutionally, is responsible for the adaptability, tolerance and compensatory capabilities of the individual to pathogenic stresses, ie the result of the refraction of external factors through the internal (constitutional) content. Determining the level of constitutional determinism of personality-typological manifestations in parents contributes to a more accurate prediction of their reaction in extreme conditions.
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47

Bilgic, A., Ü. Işık, H. Derin, R. Çolak Sivri, and H. Çaksen. "Psychiatric Symptomatology and Health-related Quality of Life in Children With Epilepsy." European Psychiatry 41, S1 (2017): S231—S232. http://dx.doi.org/10.1016/j.eurpsy.2017.01.2241.

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IntroductionThere is a limited amount of data regarding the relationship between epilepsy and psychiatric symptoms and quality of life (QoL) in children and adolescents.ObjectivesThe aim of this study was to determine the levels of depression, anxiety and attention-deficit hyperactivity disorder symptoms and health-related quality of life (HRQL) in children and adolescents with epilepsy.MethodsThe sample consisted of 75 children with epilepsy and 50 healthy controls aged 8–18 years. Questionnaires were used to evaluate the psychiatric status and HRQL of the patients.ResultsPatients had lower child-rated psychosocial and total area HRQL scores, and lower parent-rated psychosocial, physical and total area HRQL scores than the controls did. Inattention scores of the epilepsy group were significantly higher compared to controls. No significant differences were found between patients and controls in terms of anxiety and depression scores. Regarding determinants of HRQL, severity of depression and anxiety had a decreasing effect on child-rated HRQL total scores; and severity of anxiety had a decreasing effect on parent-rated HRQL total scores.ConclusionsEpilepsy is associated with poor QoL in childhood and severity of depression and anxiety are among the determinants of QoL. Clinicians should be more aware of accompanying psychiatric symptoms in epileptic patients and take the necessary precautions in the early period of the illness in an effort to improve QoL.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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48

Vafaee-Shahi, Mohammad, Reza S. Badv, Alinaghi Kazemi, et al. "Does the Vitamin D Deficiency Have Any Role in Severity or Prolongation of Seizure? A Pilot Study in Iran." Current Nutrition & Food Science 16, no. 5 (2020): 781–87. http://dx.doi.org/10.2174/1573401315666190912091832.

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Background: Based on previous studies, vitamin D deficiency could lead to nerve stimulation. The purpose of the present study was to determine frequency and duration of seizures in children with idiopathic epilepsy in two groups; normal level of vitamin D versus decreased level of vitamin D. Methods: This pilot, comparative study was carried out in Zanjan University of Medical Sciences on total 40 children aging between 2 to 12 years old (23 male and 17 female) with the diagnosis of idiopathic epilepsy. All patients were receiving anti-epileptic drugs. The initial questionnaire was completed by each parent. Total 40 epileptic cases were examined in close follow-ups every three months, during total 9 months. Meanwhile, the frequency and duration of each seizure were recorded in questionnaire at every three-month period. Vitamin D blood samples were analyzed at the beginning of the study and after 9 months following the study. Serum levels of Vitamin D were analyzed by ELISA method (Elecsys2010, RocheCo, Germany; STAR FAX; 2100), simultaneously, Vitamin D level <30 ng/ml (nanogram per milliliter) was defined as Vitamin D deficiency. Cases were divided into two groups based on Vitamin D level. The frequency and duration of convulsions were compared in patients with normal level of vitamin D versus children with decreased level of vitamin D. Data were analyzed by Chi-square and t-test methods. Results: In all 40 patients, vitamin D level less than 30 ng/ml was detected in 32% (13 patients) at the beginning of study and 35% (14 patients) in 9 months later (13 patients were common between the two groups). There was no significant relationship between the frequency of seizures, the duration of seizures and vitamin D levels in patients. The relationship between positive family history of epilepsy and the number of seizures was reported significant. The frequency of vitamin D deficiency was higher in female cases in final evaluation. Conclusion: In the present study, a considerable correlation was detected between the frequency of seizures and positive history of seizure in the family. The frequency of vitamin D deficiency was higher in female cases in final analysis. No significant relationship was detected between the number of seizures, the mean duration of seizures and serum level of Vitamin D in children who received anticonvulsant drugs. However, vitamin D deficiency in patients was not overlooked in order to prevent known complications. We recommend a randomized clinical trial in the future with an adequate sample size. Moreover, a non-epileptic control group in study would be useful.
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Duran, Marcos H. C., Catarina A. Guimarães, Maria Augusta Montenegro, Marina L. Neri, and Marilisa M. Guerreiro. "ADHD in idiopathic epilepsy." Arquivos de Neuro-Psiquiatria 72, no. 1 (2014): 12–16. http://dx.doi.org/10.1590/0004-282x20130193.

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Our aim was to clarify the correlation of attention deficit hyperactivity disorder (ADHD) with epilepsy and behavior problems. This was a cross-sectional study. Sixty children with idiopathic epilepsy were interviewed using the MTA-SNAP IV Teacher and Parent Rating Scale, Vineland Adaptive Behavior Scales and Conners’ Rating Scales. We used the chi-square test to analyze the correlation of epilepsy variables in patients with and without ADHD with a significance level of 0.05. Eight patients had ADHD symptoms (13%), seven had the inattentive ADHD subtype and only three had behavioral problems. When epileptic patients with and without ADHD symptoms were compared we found no significant difference in regard to epilepsy variables. All patients were controlled and 43% were either without AED or undergoing withdrawal. Our study revealed a low comorbidity of ADHD symptoms and epilepsy due to low interference of seizures and drug treatment on the comorbid condition.
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Graves, Nina. "Pharmacoeconomic Considerations in Treatment Options for Acute Seizures." Journal of Child Neurology 13, no. 1_suppl (1998): S27—S29. http://dx.doi.org/10.1177/0883073898013001081.

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Two pharmacoeconomic studies on the treatment of acute seizures have been conducted. In 1991, Kriel and colleagues surveyed parents of children with a history of cluster seizures, prolonged seizures, or status epilepticus who had been instructed in the use of rectal diazepam. A comparison of data before instruction with data after instruction showed a reduced need for emergency department visits with rectal diazepam. Instruction thus provided a pharmacoeconomic benefit, despite the cost of the product. In 1996, Marchetti and coworkers found that intravenous fosphenytoin was associated with fewer adverse events than intravenous phenytoin. Fosphenytoin thus reduced the need for adverse event management and provided a substantial pharmacoeconomic benefit, despite its higher cost, compared with phenytoin. This study had a number of limitations, however, and hospital pharmacists remain resistant to the use of fosphenytoin. Additional studies may provide more pharmacoeconomic data to support the greater use of fosphenytoin in the treatment of acute pediatric seizures. (J Child Neurol 1998;13(Suppl 1):S27-S29).
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