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Journal articles on the topic 'Epiphyseal cartilage'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Klinger, P., S. Lukassen, F. Ferrazzi, et al. "PEDF Is Associated with the Termination of Chondrocyte Phenotype and Catabolism of Cartilage Tissue." BioMed Research International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/7183516.

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Objective.To investigate the expression and target genes of pigment epithelium-derived factor (PEDF) in cartilage and chondrocytes, respectively.Methods.We analyzed the expression pattern of PEDF in different human cartilaginous tissues including articular cartilage, osteophytic cartilage, and fetal epiphyseal and growth plate cartilage, by immunohistochemistry and quantitative real-time (qRT) PCR. Transcriptome analysis after stimulation of human articular chondrocytes with rhPEDF was performed by RNA sequencing (RNA-Seq) and confirmed by qRT-PCR.Results.Immunohistochemically, PEDF could be d

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2

Carlson, C. S., H. D. Hilley, and D. J. Meuten. "Degeneration of Cartilage Canal Vessels Associated With Lesions of Osteochondrosis in Swine." Veterinary Pathology 26, no. 1 (1989): 47–54. http://dx.doi.org/10.1177/030098588902600108.

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Articular-epiphyseal cartilage complexes from the distal femur and humerus of five 3-month-old pigs were collected and preserved using either a conventional or a ruthenium hexammine trichloride (RHT)-supplemented fixation technique. Lesions were similar regardless of the fixation technique. Areas of necrosis were in epiphyseal but not articular cartilage from both sites of all pigs. Cartilage canals were confined to epiphyseal cartilage and contained vessels which had endothelial cells in varying stages of degeneration and necrosis. Areas of necrotic cartilage often were adjacent to or surroun

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3

Amizuka, N., H. Warshawsky, J. E. Henderson, D. Goltzman, and A. C. Karaplis. "Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation." Journal of Cell Biology 126, no. 6 (1994): 1611–23. http://dx.doi.org/10.1083/jcb.126.6.1611.

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To elucidate the role of PTHrP in skeletal development, we examined the proximal tibial epiphysis and metaphysis of wild-type (PTHrP-normal) 18-19-d-old fetal mice and of chondrodystrophic litter mates homozygous for a disrupted PTHrP allele generated via homologous recombination in embryonic stem cells (PTHrP-depleted). In the PTHrP-normal epiphysis, immunocytochemistry showed PTHrP to be localized in chondrocytes within the resting zone and at the junction between proliferative and hypertrophic zones. In PTHrP-depleted epiphyses, a diminished [3H]thymidine-labeling index was observed in the

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Kincaid, S. A., R. V. Allhands, and G. J. Pijanowski. "Chondrolysis associated with cartilage canals of the epiphyseal cartilage of the distal humerus of growing pigs." American Journal of Veterinary Research 46, no. 3 (1985): 726–32. https://doi.org/10.2460/ajvr.1985.46.03.726.

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SUMMARY The articular-epiphyseal (a-e) cartilage of the distal humeri of 7 pigs weighing 13.1 to 18.2 kg and of 3 pigs weighing 36.4 to 40.9 kg was studied. Frozen samples of a-e cartilage were stained for the presence of reduced nicotinamide adenine dinucleotide dehydrogenase, lactate dehydrogenase, isocitrate dehydrogenase, and uridine diphosphate galactose-4-epimerase. Additional frozen sections and paraffin-processed sections were stained using the Alcian blue-critical electrolyte concentration method, safranin 0-fast green, and hematoxylin and eosin. An area of grossly visible, opaque a-e

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Setiawan, Arum, Mammed Sagi, Widya Asmara, and Istriyati Istriyati. "Analisis Pertumbuhan Kartilago Epifisialis Os Tibia Fetus Mencit (Mus musculus L.) Swiss Webster Setelah Induksi Ochratoxin A Selama Periode Organogenesis." JURNAL BIOLOGI PAPUA 4, no. 1 (2018): 25–31. http://dx.doi.org/10.31957/jbp.532.

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The aims of this study were determined the effects of Ochratoxin A (OTA) on growth of fetus tibia epiphyseal cartilage during organogenesis period. Twenty four pregnant mice were divided randomly into 4 groups of 6. Ochratoxin A was dissolved in sodium bicarbonateand administered orally on seventh to fourteenth days of gestation at dosage of 0.5, 1.0, 1.5 mg/kg bw, respectively. The remaining were used as control. The fetal tibia was taken after the 18 th day of pregnancy. The growth of tibia epiphyseal cartilages were observed histologically using Erlich’s Haematoxylin-Eosin Stain. The result

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Carlson, C. S., H. D. Hilley, and C. K. Henrikson. "Ultrastructure of normal epiphyseal cartilage of the articular-epiphyseal cartilage complex in growing swine." American Journal of Veterinary Research 46, no. 2 (1985): 306–13. https://doi.org/10.2460/ajvr.1985.46.02.306.

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SUMMARY Normal epiphyseal cartilage from the articular-epiphyseal cartilage complex (a-e complex) of the distal parts of the femur and humerus of growing commercial crossbred boars was collected, embedded in plastic, and studied by light and electron microscopies. The morphology of this cartilage was determined to provide a basis for comparison with cartilage affected with osteochondrosis, an important clinical disease in swine. Normal epiphyseal cartilage from the a-e complex in growing swine was divided into 4 major regions of cells; resting, proliferating, hypertrophic, and calcifying regio

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Ohtaka, Maiko, Izumi Hiramoto, Hiroshi Minagawa, Masashi Matsuzaki, and Hideya Kodama. "Screening of the Maturity Status of the Tibial Tuberosity by Ultrasonography in Higher Elementary School Grade Schoolchildren." International Journal of Environmental Research and Public Health 16, no. 12 (2019): 2138. http://dx.doi.org/10.3390/ijerph16122138.

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This study aimed to obtain screening data on the maturity status of the tibial tuberosity in schoolchildren of higher elementary school grades for risk management of Osgood–Schlatter disease (OSD). The maturity stages and cartilage thicknesses at the tibial tuberosity were determined by ultrasonography on the occasion of a school-based musculoskeletal examination for 124 grade 5–6 elementary schoolchildren, and their associations with the students’ demographic characteristics and OSD were examined. The time-dependent changes of the maturity status of the tibial tuberosity were also examined in

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8

Kambe, K., A. Yamamoto, T. Yoshimori, K. Hirayoshi, R. Ogawa, and Y. Tashiro. "Preferential localization of heat shock protein 47 in dilated endoplasmic reticulum of chicken chondrocytes." Journal of Histochemistry & Cytochemistry 42, no. 7 (1994): 833–41. http://dx.doi.org/10.1177/42.7.8014466.

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We investigated the distribution of heat shock protein 47 (hsp47) in cultured chicken embryonic chondrocytes and epiphyseal chondrocytes of tibial bones from 1-day-old to 6-week-old chickens. Northern blot and immunoblot analyses revealed that hsp47 exists in epiphyseal cartilage and cultured chondrocytes. Confocal laser immunofluorescence microscopy showed that hsp47 was localized mainly in the many granular structures found in the cytoplasm that contain Type II collagen. Epiphyseal cartilage and cultured chondrocytes were embedded in LR White resin and hsp47 was detected by protein A-immunog

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9

Sato, Shinsuke, Song Ho Chang, Taro Kasai, et al. "Juvenile Dysplasia Epiphysealis Hemimelica with Multiple Ankle Free Body." Case Reports in Orthopedics 2021 (April 9, 2021): 1–8. http://dx.doi.org/10.1155/2021/5579684.

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Dysplasia epiphysealis hemimelica (DEH), also known as Trevor’s disease, is a rare overgrowth of cartilage that commonly arises in the epiphyseal bone of children. We report a rare case of DEH originating from a talus accompanied by multiple intra-articular free bodies in a 7-year-old patient with ankle instability. After the primary surgery for free body removal and microfracture technique for the cartilage defects in the ankle joint, the free body recurred. Secondary surgery of arthroscopic free body removal with lateral ankle ligament repair succeeded in treating the patient, without furthe

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Moskalewski, S., and J. Malejczyk. "Bone formation following intrarenal transplantation of isolated murine chondrocytes: chondrocyte-bone cell transdifferentiation?" Development 107, no. 3 (1989): 473–80. http://dx.doi.org/10.1242/dev.107.3.473.

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Isolated syngeneic epiphyseal chondrocytes transplanted into a muscle formed cartilage in which matrix resorption and endochondral ossification began at the end of the second week after transplantation. After 56 days cartilage was converted into an ossicle. In 7-day-old intrarenal transplants, epiphyseal chondrocytes formed nodules of cartilage. In 10-day-old transplants, islands of bone appeared. Slight resorption of cartilage was first noted in 14-day-old transplants of chondrocytes. After eight weeks, transplants contained mainly bone. Intramuscularly transplanted rib chondrocytes formed ca

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11

Kincaid, Steven A., Ray G. Rudd, and Sharon A. Evander. "Lipids of normal and osteochondritic cartilage of the immature canine humeral head." American Journal of Veterinary Research 46, no. 5 (1985): 1060–65. https://doi.org/10.2460/ajvr.1985.46.05.1060.

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SUMMARY Specimens of cartilage removed from the shoulder joint of dogs with osteochondritis dissecans were compared with the articular-epiphyseal cartilage from the same location of healthy dogs. The pathologic cartilage lost the lamination pattern of articular-epiphyseal cartilage from healthy dogs. Chondrocytes of healthy and pathologic cartilage contained lipid inclusions. However, in pathologic samples, the lipid inclusions were more prominent, particularly in the superficial region of the presumptive articular cartilage. Lipids in the interterritorial matrix of the pathologic cartilage we

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12

Mammoto, Takeo, and Atsushi Hirano. "Arthroscopic treatment of intra-articular dysplasia epiphysealis hemimelica of the knee." SAGE Open Medical Case Reports 6 (January 1, 2018): 2050313X1879016. http://dx.doi.org/10.1177/2050313x18790166.

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Dysplasia epiphysealis hemimelica, also known as Trevor Fairbank disease, is characterized by asymmetrical osteochondral overgrowth of the epiphyseal cartilage. The clinical presentation of dysplasia epiphysealis hemimelica is wide and variable, depending on the site of the lesion. Herein, we describe the physical examination of a 9-year-old boy with intra-articular dysplasia epiphysealis hemimelica, in whom the symptoms were elicited on “reverse Wilson’s sign”: bending the knee from 70° to 120° against resistance while externally rotating the tibia. Arthroscopic treatment of the intra-articul

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13

Poole, A. R., C. Webber, I. Pidoux, H. Choi, and L. C. Rosenberg. "Localization of a dermatan sulfate proteoglycan (DS-PGII) in cartilage and the presence of an immunologically related species in other tissues." Journal of Histochemistry & Cytochemistry 34, no. 5 (1986): 619–25. http://dx.doi.org/10.1177/34.5.3701029.

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A monoclonal antibody to a core-protein-related epitope of a small dermatan sulfate-rich proteoglycan (DS-PGII) isolated from adult bovine articular cartilage (22) was used to localize this molecule, or molecules containing this epitope, in bovine articular cartilages, in cartilage growth plate, and in other connective tissues. Using an indirect method employing peroxidase-labeled pig anti-mouse immunoglobulin G, DS-PGII was shown to be present mainly in the superficial zone of adult articular condylar cartilage of the metacarpal-phalangeal joint. In fetal articular and epiphyseal cartilages,

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14

SZTROLOVICS, Robert, Robert J. WHITE, Peter J. ROUGHLEY, and John S. MORT. "The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism." Biochemical Journal 362, no. 2 (2002): 465–72. http://dx.doi.org/10.1042/bj3620465.

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The mechanisms of aggrecan degradation in adult human articular, adult bovine nasal and fetal bovine epiphyseal cartilage in response to either interleukin-1β (IL-1β) or retinoic acid were compared using an explant culture system. Bovine nasal cartilage cultured with either IL-1β or retinoic acid exhibited significant release of glycosaminoglycan (GAG). For both factors, aggrecan proteolysis occurred predominantly at the ‘aggrecanase’ site, with no evidence for the action of matrix metalloproteinases, and resulted in the appearance of the corresponding G1 fragment in tissue extracts and in cul

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15

Huzhevskyi, Igor, Sergey Herasymenko, Mikhail Poluliakh, et al. "Histological features of articular cartilage and bone marrow reparative potential under conditions of coxarthritis in patients with radiographic signs of epiphyseal dysplasia." ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS, no. 3-4 (May 26, 2023): 91–96. http://dx.doi.org/10.15674/0030-598720223-491-96.

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Coxarthritis in patients with radiographic signs of epiphyseal dysplasia causes disturbances of social adaptation of this patients group at a young age and ensure the relevance of studying the problem of optimizing the orthopaedic treatment of this patients category. Objective. To define the tactics of orthopaedic treatment in such patient category based on study of morphological features of articular cartilage and osteogenic activity of bone marrow stem stromal cells. Materials and Methods. We have clinically examined 68 adult patients having coxarthritis in the presence of radiological signs

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Ekman, S., and Y. Ridderstråle. "Carbonic Anhydrase Localization in Normal and Osteochondrotic Joint Cartilage of Growing Pigs." Veterinary Pathology 29, no. 4 (1992): 308–15. http://dx.doi.org/10.1177/030098589202900405.

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The histochemical localization of carbonic anhydrase in the normal and osteochondrotic epiphyseal growth cartilage from 15 growing pigs (6 to 18 weeks old) was studied. All animals were clinically normal. The entire thickness of the articular-epiphyseal cartilage complex from the femoral condyles was fixed in 2% glutaraldehyde and embedded in a water-soluble glycolmethacrylate. Sections (1–2 μm) were incubated on the surface of a medium containing cobalt, phosphate, and bicarbonate. A black precipitate formed at sites of enzymatic activity. This method shows the activity of all different isoen

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Hill, Michael A., George R. Ruth, David C. Van Sickle, et al. "Histochemical morphologic features of growth cartilages in long bones of pigs of various ages." American Journal of Veterinary Research 48, no. 10 (1987): 1477–84. https://doi.org/10.2460/ajvr.1987.48.10.1477.

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SUMMARY Growth cartilages were obtained from humeri, femora, and ulnae of 31 pigs between 1 and 169 days old. On the basis of stain uptake and distribution, distinct layers were identified in articular-epiphyseal cartilage complexes and growth plates. The laminated appearance was dependent on stain uptake by territorial and interterritorial matrices and was more distinct in pigs > 15 days old. There was morphologic heterogeneity, which probably represented a functional heterogeneity, among chondrocytes in all layers and zones of both types of growth cartilage. The laminar appearance of grow

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Keene, D. R., J. T. Oxford, and N. P. Morris. "Ultrastructural localization of collagen types II, IX, and XI in the growth plate of human rib and fetal bovine epiphyseal cartilage: type XI collagen is restricted to thin fibrils." Journal of Histochemistry & Cytochemistry 43, no. 10 (1995): 967–79. http://dx.doi.org/10.1177/43.10.7560887.

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The collagen fibrils of hyaline cartilage vary in diameter depending on developmental stage and location within the tissue. In general, growth plates and fetal epiphyseal cartilages contain fibrils with diameters of less than approximately 25 nm, whereas the permanent cartilage of adult tissues contains fibrils of approximately 30-200 nm. The interstitial collagen fibrils of fetal cartilage are complex, having at least three collagen types as integral components. Type XI, a member of the fibrillar collagen class, has been proposed to limit fibril diameter. To test this proposition we sought to

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Nasu, Michiyo, Shinichiro Takayama, and Akihiro Umezawa. "Efficiency of Human Epiphyseal Chondrocytes with Differential Replication Numbers for Cellular Therapy Products." BioMed Research International 2016 (2016): 1–13. http://dx.doi.org/10.1155/2016/6437658.

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The cell-based therapy for cartilage or bone requires a large number of cells; serial passages of chondrocytes are, therefore, needed. However, fates of expanded chondrocytes from extra fingers remain unclarified. The chondrocytes from human epiphyses morphologically changed from small polygonal cells to bipolar elongated spindle cells and to large polygonal cells with degeneration at early passages. Gene of type II collagen was expressed in the cells only at a primary culture (Passage 0) and Passage 1 (P1) cells. The nodules by implantation of P0 to P8 cells were composed of cartilage and per

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Strange-Vognsen, H. H., and H. Laursen. "Nerves in Human Epiphyseal Uncalcified Cartilage." Journal of Pediatric Orthopaedics B 6, no. 1 (1997): 56–58. http://dx.doi.org/10.1097/01202412-199701000-00012.

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Fernández-Iglesias, Ángela, Rocío Fuente, Helena Gil-Peña, Laura Alonso-Durán, Fernando Santos, and José Manuel López. "The Formation of the Epiphyseal Bone Plate Occurs via Combined Endochondral and Intramembranous-Like Ossification." International Journal of Molecular Sciences 22, no. 2 (2021): 900. http://dx.doi.org/10.3390/ijms22020900.

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The formation of the epiphyseal bone plate, the flat bony structure that provides strength and firmness to the growth plate cartilage, was studied in the present study by using light, confocal, and scanning electron microscopy. Results obtained evidenced that this bone tissue is generated by the replacement of the lower portion of the epiphyseal cartilage. However, this process differs considerably from the usual bone tissue formation through endochondral ossification. Osteoblasts deposit bone matrix on remnants of mineralized cartilage matrix that serve as a scaffold, but also on non-minerali

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Salter, D. M., J. L. Godolphin, and M. S. Gourlay. "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees." Journal of Histochemistry & Cytochemistry 43, no. 4 (1995): 447–57. http://dx.doi.org/10.1177/43.4.7897185.

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During development and at maturity different forms of cartilage vary in morphology and macromolecular content. This reflects heterogeneity of chondrocyte activity, in part involving differential interactions with the adjacent extracellular matrix via specialized cell surface receptors such as integrins. We undertook an immunohistological study on a series of human fetal knee joints to assess variation in the expression of integrins by chondrocytes and potential matrix ligands in articular, epiphyseal, growth plate, and meniscal cartilage. The results show that articular chondrocytes (beta 1+,

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Meena, Devi Sahai, Sanjay Saini, Manisha Sehrawat, Vipul Yadav, and Praveen Kumar. "Dysplasia Epiphysealis Hemimelica (Trevor’s Disease) of Talus Treated with Excision, Periosteal Flap, and Open Wedge Osteotomy: A Case Report and Review of Literature." Journal of Limb Lengthening & Reconstruction 10, no. 1 (2024): 3–10. http://dx.doi.org/10.4103/jllr.jllr_21_23.

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Abstract Dysplasia epiphysealis hemimelica (DEH), also known as Trevor’s disease, is a rare disease which is skeletal developmental disorder characterized by asymmetrical growth of epiphyseal cartilage. It most frequently affects the ankle joint. Surgical treatment with complete resection is recommended before irreversible joint damage and deformity occurs. Multiple surgeries may be required if resected at an early age because recurrences are common until skeletal maturity. We present a case of DEH at the anteromedial aspect of a left ankle joint and a review of the literature.

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Ohashi-Takeuchi, H., N. Yamada, R. Hosokawa, and T. Noguchi. "Vesicles with lactate dehydrogenase and without alkaline phosphatase present in the resting zone of epiphyseal cartilage." Biochemical Journal 266, no. 1 (1990): 309–12. http://dx.doi.org/10.1042/bj2660309.

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Matrix vesicles are membrane-invested vesicles that initiate mineralization in the extracellular matrix of calcifying tissues. The epiphyseal cartilages of young-rat rib bones were divided into the growth zone and the resting zone, followed by the isolation of matrix vesicles after collagenase treatment. Matrix vesicles with both alkaline phosphatase and lactate dehydrogenase were detected in the growth cartilage found in the epiphyseal growth plates of young rabbits [Hosokawa, Uchida, Fujiwara & Noguchi (1988) J. Biol. Chem. 263, 10045-10047], but were not detected in the resting zone. By

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Tang, Meibai, Richeng Zhi, Changyi Sun, Xiaohua Wang, and Chenglin Liu. "Evaluating the value of synchrotron radiation phase-contrast CT imaging in the study of knee joint microstructure." E3S Web of Conferences 271 (2021): 03039. http://dx.doi.org/10.1051/e3sconf/202127103039.

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The knee joint is one of the tissues that often appear diseased, and the pathogenesis owing to its structure. Therefore, the micro-structure of the knee joint was studied by synchrotron radiation phasecontrast CT imaging (SRPCI-CT). The contrast and the sharpness of the reconstructed slice were calculated and analysed. From these results, the layer structure of the joint tissue can be seen. The cartilage layer (including the meniscus) is about 1.44 mm, and the epiphyseal layer is about 2.25 mm, which conforms to the actual situation of rat knees. From the 3D images, the structure of the menisc

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Leboy, P. S., I. M. Shapiro, B. D. Uschmann, O. Oshima, and D. Lin. "Gene expression in mineralizing chick epiphyseal cartilage." Journal of Biological Chemistry 263, no. 17 (1988): 8515–20. http://dx.doi.org/10.1016/s0021-9258(18)68508-4.

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Shapiro, Frederic, Evelyn Flynn, and Monica L. Calicchio. "Molecular differentiation in epiphyseal and physeal cartilage. Prominent role for gremlin in maintaining hypertrophic chondrocytes in epiphyseal cartilage." Biochemical and Biophysical Research Communications 390, no. 3 (2009): 570–76. http://dx.doi.org/10.1016/j.bbrc.2009.10.006.

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Kavanagh, Emma, Anne C. Osborne, Doreen E. Ashhurst, and Andrew A. Pitsillides. "Keratan Sulfate Epitopes Exhibit a Conserved Distribution During Joint Development That Remains Undisclosed on the Basis of Glycosaminoglycan Charge Density." Journal of Histochemistry & Cytochemistry 50, no. 8 (2002): 1039–47. http://dx.doi.org/10.1177/002215540205000806.

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Changes in glycosaminoglycan (GAG) content and distribution are vital for joint development. However, their precise character has not been established. We have used immunohistochemistry (IHC) and “critical electrolyte” Alcian blue staining to assess such changes in developing chick and rabbit joints. IHC showed chondroitin sulfate labeling in chick epiphyseal cartilage but not in interzones. In contrast, prominent labeling for keratan sulfate (KS) was restricted to chick cartilage–interzone interfaces. In rabbit knees, KS labeling was also prominent at presumptive cavity borders, but weak in i

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Aeschlimann, D., A. Wetterwald, H. Fleisch, and M. Paulsson. "Expression of tissue transglutaminase in skeletal tissues correlates with events of terminal differentiation of chondrocytes." Journal of Cell Biology 120, no. 6 (1993): 1461–70. http://dx.doi.org/10.1083/jcb.120.6.1461.

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Calcifying cartilages show a restricted expression of tissue transglutaminase. Immunostaining of newborn rat paw bones reveals expression only in the epiphyseal growth plate. Tissue transglutaminase appears first intracellularly in the proliferation/maturation zone and remains until calcification of the tissue in the lower hypertrophic zone. Externalization occurs before mineralization. Subsequently, the enzyme is present in the interterritorial matrix during provisional calcification and in the calcified cartilage cores of bone trabeculae. In trachea, mineralization occurring with maturation

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Sun, Jian, Zixin Min, Wenxiang Zhao, et al. "T-2 Toxin Induces Epiphyseal Plate Lesions via Decreased SECISBP2-Mediated Selenoprotein Expression in DA Rats, Exacerbated by Selenium Deficiency." CARTILAGE 12, no. 1 (2018): 121–31. http://dx.doi.org/10.1177/1947603518809406.

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Objective Both selenium (Se) deficiency and mycotoxin T2 lead to epiphyseal plate lesions, similar to Kashin-Beck disease (KBD). However, regulation of selenoproteins synthesis mediated by SECISBP2, in response to these 2 environmental factors, remained unclear. The present study proposed to explore the mechanism behind the cartilage degradation resulting from Se deficiency and mycotoxin T2 exposure. Design Deep chondrocyte necrosis and epiphyseal plate lesions were replicated in Dark Agouti (DA) rats by feeding them T2 toxin/Se deficiency artificial synthetic diet for 2 months. Results Se def

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Dhillon, Mandeep Singh, Mehar Dhillon, Sandeep Patel, and Siddhartha Sharma. "A Lumpy-Bumpy Painful Ankle – Trevor Disease of the Ankle in a 9-year-old." Journal of Orthopaedic Case Reports 12, no. 9 (2022): 26–29. http://dx.doi.org/10.13107/jocr.2022.v12.i09.3000.

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Introduction: Dysplasia epiphysealis hemimelica, also known as Trevor disease, is a rare skeletal development disorder of childhood, characterized by asymmetric growth of the epiphyseal cartilage in childhood. The disease can be locally aggressive at the ankle, and can result in deformity or instability. We present a case of Trevor disease involving the lateral aspect of distal tibia and talus in a 9-year-old patient, and of highlight its clinical and radiological presentation, treatment, and outcomes. Case Report: A 9-year-old male presented with a painful swelling over the lateral aspect of

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Hinek, A., A. Reiner, and A. R. Poole. "The calcification of cartilage matrix in chondrocyte culture: studies of the C-propeptide of type II collagen (chondrocalcin)." Journal of Cell Biology 104, no. 5 (1987): 1435–41. http://dx.doi.org/10.1083/jcb.104.5.1435.

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We have shown that when chondrocytes are isolated by collagenase digestion of hyaline cartilage from growth plate, nasal, and epiphyseal cartilages of bovine fetuses they rapidly elaborate an extracellular matrix in culture. Only growth plate chondrocytes can calcify this matrix as ascertained by incorporation of 45Ca2+, detection of mineral with von Kossa's stain and electron microscopy. There is an extremely close direct correlation between 45Ca2+ incorporation in the first 24 h of culture and the content of the C-propeptide of type II collagen, measured by radioimmunoassay, at the time of i

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Lamar, C. H., L. L. Eller, and J. J. Turek. "In vitro characterization of porcine juvenile articular cartilage." American Journal of Veterinary Research 48, no. 3 (1987): 515–18. https://doi.org/10.2460/ajvr.1987.48.03.515.

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SUMMARY Dispersed cell cultures were established from the articular cartilage of the proximal portion of the humerus of young pigs. Articular and epiphyseal portions of the cartilage were separated, minced, and enzymatically dispersed, using bacterial collagenase. Morphologically, 2 cell types were observed, using phase-contrast microscopy. Smaller polygonal cells (32.5 ± 3.5 μm diameter) containing cytoplasmic granules were found in both areas of the cartilage. In cultures from the articular region, cells grew as monolayer cultures and initially did not demonstrate contact inhibition. In cult

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Hall, A. Peter, T. Mitchard, M. G. Rolf, J. Stewart, and P. Duffy. "Femoral Head Growth Plate Dysplasia and Fracture in Juvenile Rabbits Induced by Off-target Antiangiogenic Treatment." Toxicologic Pathology 44, no. 6 (2016): 866–73. http://dx.doi.org/10.1177/0192623316646483.

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Epiphyseal growth plate dysplasia (chondrodysplasia) might be considered as the pathognomonic feature of antiangiogenic treatment in preclinical species as it is reliably and dose-responsively induced in rodents and monkeys with vascular endothelial growth factor receptor (VEGFR) inhibitors, fibroblast growth factor (FGF) receptor inhibitors, matrix metalloproteinase inhibitors, and vascular targeting agents. Here we report epiphyseal growth plate dysplasia in juvenile rabbits treated with an oral spleen tyrosine kinase inhibitor induced by off-target antiangiogenic inhibition of VEGF and FGF

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Takahara, Masatoshi, Masahiro Maruyama, Tomohiro Uno, et al. "Progression of Epiphyseal Cartilage and Bone Pathology in Surgically Treated Cases of Osteochondritis Dissecans of the Elbow." American Journal of Sports Medicine 49, no. 1 (2020): 162–71. http://dx.doi.org/10.1177/0363546520969423.

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Background: Although a variety of pathologic conditions associated with osteochondritis dissecans (OCD) have been reported, the pathological progression has remained unclear. Hypothesis: Separation of the immature epiphyseal cartilage is an early event in OCD, and osteonecrosis in the articular fragment is a late event. Study Design: Case Series; Level of evidence, 4. Methods: The participants were 26 boys (mean age, 13.8 years; mean skeletal age score for the elbow, 24.6 points) with capitellar OCD who underwent osteochondral autograft transplantation. A total of 28 cylindrical osteochondral

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Weber, Christian D., Filippo Migliorini, Heide Delbrück, and Frank Hildebrand. "Surgical Management of an Osteomyelitis Associated Subchondral Bone Defect in the Pediatric Knee Based on Arthroscopy, “Ossoscopy” and Bone Grafting—A Case Report." Life 12, no. 11 (2022): 1754. http://dx.doi.org/10.3390/life12111754.

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Subchondral bone defects around the knee joint are uncommon in skeletally immature patients. These lesions require comprehensive management, especially if related to periarticular bacterial infections. While pediatric osteomyelitis typically affects the metaphysis of long bones, the epiphysis is also a potential site for pyogenic osteomyelitis. Long-term sequelae may include growth plate injury and articular cartilage degradation. Primary epiphyseal subacute osteomyelitis is an extremely rare condition, mainly affecting neonates or young infants, as the cartilage of the growth plate generally

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Olstad, K., B. Ytrehus, S. Ekman, C. S. Carlson, and N. I. Dolvik. "Early Lesions of Articular Osteochondrosis in the Distal Femur of Foals." Veterinary Pathology 48, no. 6 (2011): 1165–75. http://dx.doi.org/10.1177/0300985811398250.

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Failure of the cartilage canal blood supply to epiphyseal growth cartilage has been implicated in the pathogenesis of articular osteochondrosis in horses and other animal species. In a previous study of the developmental pattern of the blood supply in the tarsus of foals, early lesions of osteochondrosis were consistently found in regions where the cartilage canal vessels traversed the chondro-osseous junction. The developmental pattern of blood vessels has also been described in the distal femoral epiphysis; however, the group of foals examined in that study did not have lesions of osteochond

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He, P., F. X. Aherne, T. Nakano, A. L. Schaefer, and J. R. Thompson. "Analysis of different layers of joint cartilage from pigs treated with and without recombinant porcine somatotropin (rpST)." Canadian Journal of Animal Science 74, no. 3 (1994): 559–61. http://dx.doi.org/10.4141/cjas94-079.

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This study was undertaken to determine the concentrations of collagen and glycosaminoglycan (GAG) in different layers of joint cartilage of pigs. Effects of recombinant porcine somatotropin (rpST) treatment of pigs on cartilage composition was also examined. The results demonstrated that the concentrations of GAG uronic acid and collagen (measured as hydroxyproline) varied (P < 0.05) between different layers and were reduced (P < 0.05) by the rpST treatment. Key words: Osteochondrosis, articular-epiphyseal cartilage, hydroxyproline, glycosaminoglycan, recombinant porcine somatotropin, pi

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Kobayakawa, Masahiro, Hisashi Iwata, Kenneth S. Brown, and Koji Kimata. "Abnormal Collagen Fibrillogenesis in Epiphyseal Cartilage of CMD (Cartilage Matrix Deficiency) Mouse." Collagen and Related Research 5, no. 2 (1985): 137–47. http://dx.doi.org/10.1016/s0174-173x(85)80035-2.

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KUSUHARA, Seiji, Etsuro HORI, Eiichi WATANABE, and Yasuhiro SAITO. "Calcification of Broiler Epiphyseal Cartilage Using Casein Phosphopeptide." Japanese poultry science 29, no. 4 (1992): 254–61. http://dx.doi.org/10.2141/jpsa.29.254.

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KAWABE, N., M. G. EHRLICH, and H. J. MANKIN. "In Vivo Degradation Systems of the Epiphyseal Cartilage." Clinical Orthopaedics and Related Research &NA;, no. 211 (1986): 244???251. http://dx.doi.org/10.1097/00003086-198610000-00032.

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Kawabe, N., M. G. Ehrlich, and H. J. Mankin. "IN VIVO DEGRADATION SYSTEMS OF THE EPIPHYSEAL CARTILAGE." Journal of Pediatric Orthopaedics 7, no. 2 (1987): 244. http://dx.doi.org/10.1097/01241398-198703000-00037.

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Hunter, Graeme K., and Shawn M. Bader. "A mathematical modelling study of epiphyseal cartilage calcification." Journal of Theoretical Biology 138, no. 2 (1989): 195–211. http://dx.doi.org/10.1016/s0022-5193(89)80139-0.

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Amizuka, Norio. "Histology of epiphyseal cartilage calcification and endochondral ossification." Frontiers in Bioscience E4, no. 6 (2012): 2085–100. http://dx.doi.org/10.2741/e526.

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Genbun, Yoshikazu. "The effect of electrical stimulation on epiphyseal cartilage." Journal of Nippon Medical School 58, no. 4 (1991): 391–98. http://dx.doi.org/10.1272/jnms1923.58.391.

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Leach, Roland M., and Carol V. Gay. "Role of Epiphyseal Cartilage in Endochondral Bone Formation." Journal of Nutrition 117, no. 4 (1987): 784–90. http://dx.doi.org/10.1093/jn/117.4.784.

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Inal, Sermet, Kadir Gok, Arif Gok, Ahmet Murat Pinar, and Canan Inal. "Comparison of Biomechanical Effects of Different Configurations of Kirschner Wires on the Epiphyseal Plate and Stability in a Salter-Harris Type 2 Distal Femoral Fracture Model." Journal of the American Podiatric Medical Association 109, no. 1 (2019): 13–21. http://dx.doi.org/10.7547/16-112.

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Background: We sought to investigate the different configurations of Kirschner wires used in distal femur Salter-Harris (SH) type 2 epiphyseal fracture for stabilization after reduction under axial, rotational, and bending forces and to define the biomechanical effects on the epiphyseal plate and the fracture line and decide which was more advantageous. Methods: The SH type 2 fracture was modeled using design software for four different configurations: cross, cross-parallel, parallel medial, and parallel lateral with two Kirschner wires, and computer-aided numerical analyses of the different c

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Adams, Christopher S., and Irving M. Shapiro. "The Fate of the Terminally Differentiated Chondrocyte: Evidence for Microenvironmental Regulation of Chondrocyte Apoptosis." Critical Reviews in Oral Biology & Medicine 13, no. 6 (2002): 465–73. http://dx.doi.org/10.1177/154411130201300604.

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Chondrocytes contained within the epiphyseal growth plate promote rapid bone growth. To achieve growth, cells activate a maturation program that results in an increase in chondrocyte number and volume and elaboration of a mineralized matrix; subsequently, the matrix is resorbed and the terminally differentiated cells are deleted from the bone. The major objective of this review is to examine the fate of the epiphyseal chondrocytes in the growing bone. Current studies strongly suggest that the terminally differentiated epiphyseal cells are deleted from the cartilage by apoptosis. Indeed, morpho

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Chen, Mei-Feng, Chih-Chien Hu, Yung-Heng Hsu, et al. "Characterization and Advancement of an Evaluation Method for the Treatment of Spontaneous Osteoarthritis in STR/ort Mice: GRGDS Peptides as a Potential Treatment for Osteoarthritis." Biomedicines 11, no. 4 (2023): 1111. http://dx.doi.org/10.3390/biomedicines11041111.

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STR/ort mice spontaneously exhibit the typical osteoarthritis (OA) phenotype. However, studies describing the relationship between cartilage histology, epiphyseal trabecular bone, and age are lacking. We aimed to evaluate the typical OA markers and quantify the subchondral bone trabecular parameters in STR/ort male mice at different weeks of age. We then developed an evaluation model for OA treatment. We graded the knee cartilage damage using the Osteoarthritis Research Society International (OARSI) score in STR/ort male mice with or without GRGDS treatment. We measured the levels of typical O

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Kan, Hiroyuki, Yuji Arai, Shuji Nakagawa, et al. "Arthroscopic Microfracture Technique for Cartilage Damage to the Lateral Condyle of the Tibia." Case Reports in Orthopedics 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/795759.

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This report describes the use of arthroscopic microfracture to treat a 10-year-old female patient with extensive damage to the cartilage of the lateral condyle of the tibia before epiphyseal closure, resulting in good cartilage recovery. Magnetic resonance imaging showed a defect in part of the load-bearing surface of the articular cartilage of the condyle articular of the tibia. The patient was diagnosed with damage to the lateral condyle cartilage of the tibia following meniscectomy, and arthroscopic surgery was performed. The cartilage defect measured approximately 20 × 20 mm, and microfrac

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