Academic literature on the topic 'Epithelial Cells – secretion'

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Journal articles on the topic "Epithelial Cells – secretion"

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Brown, D., and S. Breton. "Mitochondria-rich, proton-secreting epithelial cells." Journal of Experimental Biology 199, no. 11 (1996): 2345–58. http://dx.doi.org/10.1242/jeb.199.11.2345.

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Several transporting epithelia in vertebrates and invertebrates contain cells that are specialized for proton or bicarbonate secretion. These characteristic 'mitochondria-rich' (MR) cells have several typical features, the most important of which is an extremely high expression of a vacuolar-type proton-pumping ATPase (H+V-ATPase) both on intracellular vesicles and on specific domains of their plasma membrane. Physiological modulation of proton secretion is achieved by recycling the H+V-ATPase between the plasma membrane and the cytoplasm in a novel type of nonclathrin-coated vesicle. In the k
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Kang, Ju Wan, Yong Hyuk Lee, Min Jeong Kang, et al. "Synergistic mucus secretion by histamine and IL-4 through TMEM16A in airway epithelium." American Journal of Physiology-Lung Cellular and Molecular Physiology 313, no. 3 (2017): L466—L476. http://dx.doi.org/10.1152/ajplung.00103.2017.

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Histamine is an important mediator of allergic reactions, and mucus hypersecretion is a major allergic symptom. However, the direct effect of histamine on mucus secretion from airway mucosal epithelia has not been clearly demonstrated. TMEM16A is a Ca2+-activated chloride channel, and it is closely related to fluid secretion in airway mucosal epithelia. We investigated whether histamine directly induces fluid secretion from epithelial cells or submucosal glands (SMG) and mechanisms related, therewith, in allergic airway diseases. In pig airway tissues from the nose or trachea, histamine was a
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Valentich, J. D., and J. N. Forrest. "Cl- secretion by cultured shark rectal gland cells. I. Transepithelial transport." American Journal of Physiology-Cell Physiology 260, no. 4 (1991): C813—C823. http://dx.doi.org/10.1152/ajpcell.1991.260.4.c813.

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To facilitate analysis of the regulation of epithelial Cl- transport by hormones, neurotransmitters, and autocrine mediators, we have developed a primary monolayer culture system for shark rectal gland (SRG) epithelial cells. Cultures exhibit vigorous transcellular Cl- secretion which can be measured using short-circuit current or 36Cl flux methods. Transport is markedly reduced by bumetanide or barium, inhibitors of Na(+)-K(+)-2Cl- cotransport and K+ channels, respectively. This indicates that Cl- secretion by SRG monolayers occurs by a mechanism similar to that described in numerous native C
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Gewirtz, Andrew T., Andrew M. Siber, James L. Madara, and Beth A. McCormick. "Orchestration of Neutrophil Movement by Intestinal Epithelial Cells in Response to Salmonella typhimurium Can Be Uncoupled from Bacterial Internalization." Infection and Immunity 67, no. 2 (1999): 608–17. http://dx.doi.org/10.1128/iai.67.2.608-617.1999.

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ABSTRACT Intestinal epithelial cells respond to Salmonella typhimurium by internalizing this pathogen and secreting, in a polarized manner, an array of chemokines which direct polymorphonuclear leukocyte (PMN) movement. Notably, interleukin-8 (IL-8) is secreted basolaterally and directs PMN through the lamina propria, whereas pathogen-elicited epithelial chemoattractant (PEEC) is secreted apically and directs PMN migration across the epithelial monolayer to the intestinal lumen. While most studies of S. typhimuriumpathogenicity have focused on the mechanism by which this bacterium invades its
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Marino, L. R., and C. U. Cotton. "Immortalization of bovine pancreatic duct epithelial cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 270, no. 4 (1996): G676—G683. http://dx.doi.org/10.1152/ajpgi.1996.270.4.g676.

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Pancreatic duct cell lines have been isolated from a number of animal and human tumors, but none appear to express ion transport properties expected for differentiated pancreatic duct epithelial cells. We sought to generate an immortalized ductal cell line from well-differentiated primary cultures of bovine pancreatic duct epithelium. Epithelial cells from the main duct of the bovine pancreas were isolated and immortalized by transfection with a DNA construct encoding simian virus 40 large T antigen. A single clone (BPD1) survived negative selection and was maintained in culture for > 100 p
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Johanesen, Priscilla A., and Michael B. Dwinell. "Flagellin-Independent Regulation of Chemokine Host Defense in Campylobacter jejuni-Infected Intestinal Epithelium." Infection and Immunity 74, no. 6 (2006): 3437–47. http://dx.doi.org/10.1128/iai.01740-05.

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ABSTRACT Campylobacter jejuni is a leading cause of bacterial food-borne diarrheal disease throughout the world and the most frequent antecedent of autoimmune neuropathy Guillain-Barré syndrome. While infection is associated with immune memory, little is known regarding the role of the epithelium in targeting dendritic cells (DC) for initiating the appropriate adaptive immune response to C. jejuni. The objective of this study was to define the role for the intestinal epithelium in the induction of the adaptive immune response in C. jejuni infection by assessing the production of DC and T-cell
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O’Malley, Yunxia, Pavana G. Rotti, Ian M. Thornell, et al. "Development of a polarized pancreatic ductular cell epithelium for physiological studies." Journal of Applied Physiology 125, no. 1 (2018): 97–106. http://dx.doi.org/10.1152/japplphysiol.00043.2018.

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Pancreatic ductular epithelial cells comprise the majority of duct cells in pancreas, control cystic fibrosis transmembrane conductance regulator (CFTR)-dependent bicarbonate ([Formula: see text]) secretion, but are difficult to grow as a polarized monolayer. Using NIH-3T3-J2 fibroblast feeder cells and a Rho-associated kinase inhibitor, we produced well-differentiated and polarized porcine pancreatic ductular epithelial cells. Cells grown on semipermeable filters at the air-liquid interface developed typical epithelial cell morphology and stable transepithelial resistance and expressed epithe
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Verghese, George M., Michael F. Gutknecht, and George H. Caughey. "Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor." American Journal of Physiology-Cell Physiology 291, no. 6 (2006): C1258—C1270. http://dx.doi.org/10.1152/ajpcell.00637.2005.

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Prostasin, a trypsinlike serine peptidase, is highly expressed in prostate, kidney, and lung epithelia, where it is bound to the cell surface, secreted, or both. Prostasin activates the epithelial sodium channel (ENaC) and suppresses invasion of prostate and breast cancer cells. The studies reported here establish mechanisms of membrane anchoring and secretion in kidney and lung epithelial cells and demonstrate a critical role for prostasin in regulating epithelial monolayer function. We report that endogenous mouse prostasin is glycosylphosphatidylinositol (GPI) anchored to the cell surface a
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Watanabe, Kazuyoshi, Shigemi Kinoshita, and Hideo Nakagawa. "Gelatinase Secretion by Glomerular Epithelial Cells." Nephron 56, no. 4 (1990): 405–9. http://dx.doi.org/10.1159/000186184.

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Zheng, Jie, Jianghong Meng, Shaohua Zhao, Ruby Singh та Wenxia Song. "Campylobacter-Induced Interleukin-8 Secretion in Polarized Human Intestinal Epithelial Cells Requires Campylobacter-Secreted Cytolethal Distending Toxin- and Toll-Like Receptor-Mediated Activation of NF-κB". Infection and Immunity 76, № 10 (2008): 4498–508. http://dx.doi.org/10.1128/iai.01317-07.

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ABSTRACT Campylobacter jejuni and Campylobacter coli colonize and infect the intestinal epithelium and cause acute inflammatory diarrhea. The intestinal epithelium serves as a physical barrier to, and a sensor of, bacterial infection by secreting proinflammatory cytokines. This study examined the mechanisms for Campylobacter-induced secretion of the proinflammatory chemokine interleukin-8 (IL-8) by using polarized T84 human colonic epithelial cells as a model. C. jejuni increased the secretion of both IL-8 and tumor necrosis factor alpha (TNF-α) in polarized epithelial cells. However, the incr
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Dissertations / Theses on the topic "Epithelial Cells – secretion"

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Hong, Hee Ling. "Regulation of neutral proteinase and plasminogen activator secretion by epithelial cells in vitro." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24687.

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The aim of this thesis was to study the regulation of proteinase secretion by epithelial cells (E-cells) derived from the epithelial cell rests of Malassez. Since these epithelial cell rests are present only in small numbers in-vivo, E-cells derived from porcine cell rests were cultured according to Brunette et al. (1976) and conditions chosen so that detectable amounts of the proteinases, neutral proteinase and plasminogen activator, could be obtained. The regulation of the secretion of these enzymes was investigated by varying the cell population density, adding E.Coli lipopolysaccharide to
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Wang, Dong. "Regulation of anion secretion in human airway epithelial cells /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202009%20WANG.

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Turner, Mark Duncan. "Molecular mechanisms of secretion from murine mammary epithelial cells." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240599.

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Shan, Jiajie. "Mechanisms of anion and fluid secretion by airway epithelial cells." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123109.

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Anion transport drives fluid into the airways and is essential for humidifying inspired air and supplying surface liquid for mucociliary transport. Despite the importance of airway secretion in diseases such as cystic fibrosis, the cellular mechanisms of anion and fluid secretion remain poorly understood. To clarify these mechanisms, I studied the Calu-3 cell line, a widely used model for serous cells in airway submucosal glands.First, I studied anion transport using a technique which combines electrical measurement of ion transport and pH-stat. Although a small fraction of the Cl- secretion r
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Duncan, Jennifer Sarah. "Investigations into the secretory pathway of mammary epithelial cells." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263902.

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Clancy, Sinead M. "The inhibitory regulation of mucin secretion from airway epithelial goblet cells." Thesis, University of Brighton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289429.

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Malreddy, Pradeep Reddy. "Potassium channels support anion secretion in porcine vas deferens epithelial cells." Thesis, Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/1463.

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Lowes, Simon. "Multiple pathways for organic solute secretion by human intestinal epithelial (Caco-2) cells." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366518.

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Rennison, Michelle Elizabeth. "Investigation into the control of milk protein secretion from mouse mammary epithelial cells." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386822.

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Chan, Po-tong Timothy. "Adrenergic control and its mechanism of stimulation of electrogenic anion secretion in primary cultures of rat epididymal eipthelial cells /." [Hong Kong : University of Hong Kong], 1990. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13183308.

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Books on the topic "Epithelial Cells – secretion"

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Mascarenhas, John Omar. Polarized secretion of IL-6 by intestinal epithelial cells. 1995.

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Clancy, Sinead M. The inhibitory regulation of mucin secretion from airway epithelial goblet cells. 2001.

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Winyard, Paul. Human kidney development. Edited by Adrian Woolf. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0343.

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The kidneys perform diverse functions including excretion of nitrogenous waste products, homeostasis of water, electrolytes and acid–base balance, and hormone secretion. The simplest functional unit within the kidneys is the nephron, which consists of specialized segments from glomerulus, through proximal tubule, loop of Henle, and distal tubule. Human nephrogenesis starts with two stages of transient kidneys, termed the pronephros and mesonephros, and ends with development of a permanent organ from the metanephros on each side. The latter consists of just a few hundred cells when it is formed
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Book chapters on the topic "Epithelial Cells – secretion"

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Lau, K. R., A. C. Elliott, P. D. Brown, and R. M. Case. "Bicarbonate Transport by Salivary Gland Acinar Cells." In Epithelial Secretion of Water and Electrolytes. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75033-5_12.

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Nishiyama, A., H. Hayashi, H. Takahashi, and Y. Saito. "Electrophysiology of Salivary Acinar Cells: Microelectrode Studies." In Epithelial Secretion of Water and Electrolytes. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75033-5_13.

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Gögelein, H., A. Schmid, T. Kemmer, and I. Schulz. "Ion Channels in the Intracellular Organelles of Secretory Cells." In Epithelial Secretion of Water and Electrolytes. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75033-5_4.

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Dunne, M. J., and O. H. Petersen. "Ion Channels in Insulin-Secreting Cells: Their Role in Stimulus-Secretion Coupling." In Epithelial Secretion of Water and Electrolytes. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75033-5_20.

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McPherson, M. A., D. K. Shori, C. Lloyd Mills, M. C. Goodchild, and R. L. Dormer. "Altered Biochemical Regulation of Secretion in Cystic Fibrosis Epithelial Cells." In Advances in Experimental Medicine and Biology. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-5934-0_18.

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Morris, A. P., S. A. Cunningham, D. J. Benos, and R. A. Frizzell. "Protein Targeting and the Control Of C1− Secretion in Colonic Epithelial Cells." In Molecular Mechanisms of Membrane Traffic. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-662-02928-2_53.

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Kunchithapautham, Kannan, Mausumi Bandyopadhyay, Mohammad Dahrouj, Joshua M. Thurman, and Bärbel Rohrer. "Sublytic Membrane-Attack-Complex Activation and VEGF Secretion in Retinal Pigment Epithelial Cells." In Retinal Degenerative Diseases. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-0631-0_4.

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McGee, Dennis W., Jerry R. McGhee, Kenneth W. Beagley, and Wilhelm K. Aicher. "The Regulation of IL-6 Secretion from IEC-6 Intestinal Epithelial Cells by Cytokines and Mucosally Important Antigens." In Advances in Experimental Medicine and Biology. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1941-6_47.

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Bland, P. W. "Antigen Presentation by Gut Epithelial Cells: Secretion by Rat Enterocytes of a Factor with IL-1-Like Activity." In Recent Advances in Mucosal Immunology. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5344-7_25.

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Selkoe, D. J. "Physiological Production and Polarized Secretion of the Amyloid β-Peptide in Epithelial Cells: A Route to the Mechanism of Alzheimer’s Disease." In Alzheimer’s Disease: Lessons from Cell Biology. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79423-0_7.

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Conference papers on the topic "Epithelial Cells – secretion"

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Dunlevy, FK, CM Greene, and NG McElvaney. "SHP1: A Regulator of IL-8 Secretion in Epithelial Cells?." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2830.

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Larsen, Melinda, Riffard Jean-Gilles, David Soscia, et al. "Development of Nanofiber Scaffolds for Engineering an Artificial Salivary Gland." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13372.

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There is currently a significant clinical need for artificial salivary glands as a therapeutic option for patients suffering from xerostomia. To achieve unidirectional fluid secretion, the epithelial acinar cells must establish and maintain polarity by partitioning the plasma membrane into distinct apical and basolateral membrane surfaces to achieve unidirectional fluid secretion. Establishment and maintenance of epithelial acinar cell polarity has been difficult to achieve in vitro, and yet is critical saliva secretion in an engineered salivary gland. Physical properties of the scaffold provi
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Harris, William T., John P. Clancy, Hernan Grenett, and James S. Hagood. "TGF-b1 Secretion And Signaling In CF Fibroblasts And Epithelial Cells." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3518.

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Stern, Eric, Yiling Tu, Randi Stern, Bertha Marroquin, Sangeeta Bhorade, and Steven R. White. "Cyclosporine Does Not Affect Cytokine Secretion Of Differentiated Allograft Epithelial Cells." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6434.

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Naito, M., T. Takagi, A. Fujiwara, et al. "Protein S Inhibits the Secretion of Inflammatory Cytokines from Alveolar Epithelial Cells." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5676.

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Kreindler, JL, A. Savitski, and NA Cohen. "Whole Cigarette Smoke Inhibits Chloride Secretion in Normal Human Bronchial Epithelial Cells." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4948.

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Kanoh, Soichiro, Tsuyoshi Tanabe, and Bruce K. Rubin. "Dapsone Inhibits Lipopolysaccharide-induced IL-8 Secretion From Human Bronchial Epithelial Cells." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5754.

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Li, Hong, Qingyuan Chen, Ernst W. Spannhake, Viswanathan Natarajan, and Yutong Zhao. "Lysophosphatidic Acid Increases Soluble ST2 Expression And Secretion In Human Bronchial Epithelial Cells." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1403.

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Ramu, Sangeetha, Leif Bjermer, Jonas Erjefält, Lena Uller, and Cecilia Andersson. "Mast cell tryptase induce alarmin release and secretion of pro-inflammatory cytokines from bronchial epithelial cells." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa5002.

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Conner, Gregory E., Pedro Ivonnet, and Matthias Salathe. "Hydrogen Peroxide Activates Prostanoid Receptors To Increase Anion Secretion By Human Bronchial Epithelial Cells." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4227.

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