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Journal articles on the topic 'Epithelial Cells – secretion'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Brown, D., and S. Breton. "Mitochondria-rich, proton-secreting epithelial cells." Journal of Experimental Biology 199, no. 11 (1996): 2345–58. http://dx.doi.org/10.1242/jeb.199.11.2345.

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Several transporting epithelia in vertebrates and invertebrates contain cells that are specialized for proton or bicarbonate secretion. These characteristic 'mitochondria-rich' (MR) cells have several typical features, the most important of which is an extremely high expression of a vacuolar-type proton-pumping ATPase (H+V-ATPase) both on intracellular vesicles and on specific domains of their plasma membrane. Physiological modulation of proton secretion is achieved by recycling the H+V-ATPase between the plasma membrane and the cytoplasm in a novel type of nonclathrin-coated vesicle. In the k

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2

Kang, Ju Wan, Yong Hyuk Lee, Min Jeong Kang, et al. "Synergistic mucus secretion by histamine and IL-4 through TMEM16A in airway epithelium." American Journal of Physiology-Lung Cellular and Molecular Physiology 313, no. 3 (2017): L466—L476. http://dx.doi.org/10.1152/ajplung.00103.2017.

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Histamine is an important mediator of allergic reactions, and mucus hypersecretion is a major allergic symptom. However, the direct effect of histamine on mucus secretion from airway mucosal epithelia has not been clearly demonstrated. TMEM16A is a Ca2+-activated chloride channel, and it is closely related to fluid secretion in airway mucosal epithelia. We investigated whether histamine directly induces fluid secretion from epithelial cells or submucosal glands (SMG) and mechanisms related, therewith, in allergic airway diseases. In pig airway tissues from the nose or trachea, histamine was a

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3

Valentich, J. D., and J. N. Forrest. "Cl- secretion by cultured shark rectal gland cells. I. Transepithelial transport." American Journal of Physiology-Cell Physiology 260, no. 4 (1991): C813—C823. http://dx.doi.org/10.1152/ajpcell.1991.260.4.c813.

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To facilitate analysis of the regulation of epithelial Cl- transport by hormones, neurotransmitters, and autocrine mediators, we have developed a primary monolayer culture system for shark rectal gland (SRG) epithelial cells. Cultures exhibit vigorous transcellular Cl- secretion which can be measured using short-circuit current or 36Cl flux methods. Transport is markedly reduced by bumetanide or barium, inhibitors of Na(+)-K(+)-2Cl- cotransport and K+ channels, respectively. This indicates that Cl- secretion by SRG monolayers occurs by a mechanism similar to that described in numerous native C

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4

Gewirtz, Andrew T., Andrew M. Siber, James L. Madara, and Beth A. McCormick. "Orchestration of Neutrophil Movement by Intestinal Epithelial Cells in Response to Salmonella typhimurium Can Be Uncoupled from Bacterial Internalization." Infection and Immunity 67, no. 2 (1999): 608–17. http://dx.doi.org/10.1128/iai.67.2.608-617.1999.

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ABSTRACT Intestinal epithelial cells respond to Salmonella typhimurium by internalizing this pathogen and secreting, in a polarized manner, an array of chemokines which direct polymorphonuclear leukocyte (PMN) movement. Notably, interleukin-8 (IL-8) is secreted basolaterally and directs PMN through the lamina propria, whereas pathogen-elicited epithelial chemoattractant (PEEC) is secreted apically and directs PMN migration across the epithelial monolayer to the intestinal lumen. While most studies of S. typhimuriumpathogenicity have focused on the mechanism by which this bacterium invades its

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5

Marino, L. R., and C. U. Cotton. "Immortalization of bovine pancreatic duct epithelial cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 270, no. 4 (1996): G676—G683. http://dx.doi.org/10.1152/ajpgi.1996.270.4.g676.

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Pancreatic duct cell lines have been isolated from a number of animal and human tumors, but none appear to express ion transport properties expected for differentiated pancreatic duct epithelial cells. We sought to generate an immortalized ductal cell line from well-differentiated primary cultures of bovine pancreatic duct epithelium. Epithelial cells from the main duct of the bovine pancreas were isolated and immortalized by transfection with a DNA construct encoding simian virus 40 large T antigen. A single clone (BPD1) survived negative selection and was maintained in culture for > 100 p

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6

Johanesen, Priscilla A., and Michael B. Dwinell. "Flagellin-Independent Regulation of Chemokine Host Defense in Campylobacter jejuni-Infected Intestinal Epithelium." Infection and Immunity 74, no. 6 (2006): 3437–47. http://dx.doi.org/10.1128/iai.01740-05.

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ABSTRACT Campylobacter jejuni is a leading cause of bacterial food-borne diarrheal disease throughout the world and the most frequent antecedent of autoimmune neuropathy Guillain-Barré syndrome. While infection is associated with immune memory, little is known regarding the role of the epithelium in targeting dendritic cells (DC) for initiating the appropriate adaptive immune response to C. jejuni. The objective of this study was to define the role for the intestinal epithelium in the induction of the adaptive immune response in C. jejuni infection by assessing the production of DC and T-cell

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7

O’Malley, Yunxia, Pavana G. Rotti, Ian M. Thornell, et al. "Development of a polarized pancreatic ductular cell epithelium for physiological studies." Journal of Applied Physiology 125, no. 1 (2018): 97–106. http://dx.doi.org/10.1152/japplphysiol.00043.2018.

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Pancreatic ductular epithelial cells comprise the majority of duct cells in pancreas, control cystic fibrosis transmembrane conductance regulator (CFTR)-dependent bicarbonate ([Formula: see text]) secretion, but are difficult to grow as a polarized monolayer. Using NIH-3T3-J2 fibroblast feeder cells and a Rho-associated kinase inhibitor, we produced well-differentiated and polarized porcine pancreatic ductular epithelial cells. Cells grown on semipermeable filters at the air-liquid interface developed typical epithelial cell morphology and stable transepithelial resistance and expressed epithe

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8

Verghese, George M., Michael F. Gutknecht, and George H. Caughey. "Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor." American Journal of Physiology-Cell Physiology 291, no. 6 (2006): C1258—C1270. http://dx.doi.org/10.1152/ajpcell.00637.2005.

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Prostasin, a trypsinlike serine peptidase, is highly expressed in prostate, kidney, and lung epithelia, where it is bound to the cell surface, secreted, or both. Prostasin activates the epithelial sodium channel (ENaC) and suppresses invasion of prostate and breast cancer cells. The studies reported here establish mechanisms of membrane anchoring and secretion in kidney and lung epithelial cells and demonstrate a critical role for prostasin in regulating epithelial monolayer function. We report that endogenous mouse prostasin is glycosylphosphatidylinositol (GPI) anchored to the cell surface a

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9

Watanabe, Kazuyoshi, Shigemi Kinoshita, and Hideo Nakagawa. "Gelatinase Secretion by Glomerular Epithelial Cells." Nephron 56, no. 4 (1990): 405–9. http://dx.doi.org/10.1159/000186184.

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10

Zheng, Jie, Jianghong Meng, Shaohua Zhao, Ruby Singh та Wenxia Song. "Campylobacter-Induced Interleukin-8 Secretion in Polarized Human Intestinal Epithelial Cells Requires Campylobacter-Secreted Cytolethal Distending Toxin- and Toll-Like Receptor-Mediated Activation of NF-κB". Infection and Immunity 76, № 10 (2008): 4498–508. http://dx.doi.org/10.1128/iai.01317-07.

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ABSTRACT Campylobacter jejuni and Campylobacter coli colonize and infect the intestinal epithelium and cause acute inflammatory diarrhea. The intestinal epithelium serves as a physical barrier to, and a sensor of, bacterial infection by secreting proinflammatory cytokines. This study examined the mechanisms for Campylobacter-induced secretion of the proinflammatory chemokine interleukin-8 (IL-8) by using polarized T84 human colonic epithelial cells as a model. C. jejuni increased the secretion of both IL-8 and tumor necrosis factor alpha (TNF-α) in polarized epithelial cells. However, the incr

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11

Villanger, O., T. Veel, and M. G. Raeder. "Secretin causes H+ secretion from intrahepatic bile ductules by vacuolar-type H(+)-ATPase." American Journal of Physiology-Gastrointestinal and Liver Physiology 265, no. 4 (1993): G719—G724. http://dx.doi.org/10.1152/ajpgi.1993.265.4.g719.

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Intrahepatic bile duct epithelial cells contribute to bile formation by hormone-dependently secreting HCO3- to bile and H+ to periductular fluid. The present study was undertaken to determine whether the secretin-induced H+ secretion is due to activation of a H(+)-ATPase or Na(+)-H+ exchange. H+ secretion was estimated from the rate of intracellular pH (pHi) recovery after acid loading (24 mM NH4Cl) of microdissected bile ductules from pig liver mounted in a flow-through chamber on the stage of a microscope. pHi was measured from an estimated average of 10-15 epithelial cells using the fluores

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12

Hug, Martin J., Tsutomu Tamada, and Robert J. Bridges. "CFTR and Bicarbonate Secretion to Epithelial Cells." Physiology 18, no. 1 (2003): 38–42. http://dx.doi.org/10.1152/nips.01412.2002.

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Defective HCO3– and fluid secretion are hallmarks of the pathophysiology of the pancreas of cystic fibrosis patients. Recently, impaired HCO3– secretion has been shown in most tissues known to express the cystic fibrosis transmembrane conductance regulator (CFTR). New results suggest that CFTR plays an important role in the transcellular secretion of HCO3–.

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13

Lee, Min Goo, Ehud Ohana, Hyun Woo Park, Dongki Yang, and Shmuel Muallem. "Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3−Secretion." Physiological Reviews 92, no. 1 (2012): 39–74. http://dx.doi.org/10.1152/physrev.00011.2011.

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Fluid and HCO3−secretion is a vital function of all epithelia and is required for the survival of the tissue. Aberrant fluid and HCO3−secretion is associated with many epithelial diseases, such as cystic fibrosis, pancreatitis, Sjögren's syndrome, and other epithelial inflammatory and autoimmune diseases. Significant progress has been made over the last 20 years in our understanding of epithelial fluid and HCO3−secretion, in particular by secretory glands. Fluid and HCO3−secretion by secretory glands is a two-step process. Acinar cells secrete isotonic fluid in which the major salt is NaCl. Su

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14

Kreindler, James L., Carol A. Bertrand, Robert J. Lee, et al. "Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 296, no. 2 (2009): L257—L266. http://dx.doi.org/10.1152/ajplung.00344.2007.

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The innate immune functions of human airways include mucociliary clearance and antimicrobial peptide activity. Both functions may be affected by changes in epithelial ion transport. Interleukin-17A (IL-17A), which has a receptor at the basolateral membrane of airway epithelia, is a T cell cytokine that has been shown to increase mucus secretion and antimicrobial peptide production by human bronchial epithelial (HBE) cells. Furthermore, IL-17A levels are increased in sputum from patients during pulmonary exacerbations of cystic fibrosis. Therefore, we investigated the effects of IL-17A on basal

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15

Thorn, Peter. "New insights into secretion in epithelial cells." Physiology News, Autumn 2005 (September 1, 2005): 20–21. http://dx.doi.org/10.36866/pn.60.20.

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16

Nathanson, M. H., A. D. Burgstahler, A. Mennone, and J. L. Boyer. "Characterization of cytosolic Ca2+ signaling in rat bile duct epithelia." American Journal of Physiology-Gastrointestinal and Liver Physiology 271, no. 1 (1996): G86—G96. http://dx.doi.org/10.1152/ajpgi.1996.271.1.g86.

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Bile duct epithelia play an important role in the formation and conditioning of bile. However, hormonal responses in this epithelial tissue are incompletely understood. Secretin increases ductular secretion through the intracellular messenger adenosine 3',5'-cyclic monophosphate (cAMP), but whether hormones increase cytosolic Ca2+ (Ca2+(i)) in these cells and whether Ca2+(i) regulates duct secretion is unknown. To address these questions, we examined Ca2+(i) signaling in isolated rat bile duct units using ratio microspectrofluorometry and confocal microscopy. We also used videomicroscopy to ex

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17

Wang, Jehng-Kang, Ming-Shyue Lee, I.-Chu Tseng, et al. "Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition." American Journal of Physiology-Cell Physiology 297, no. 2 (2009): C459—C470. http://dx.doi.org/10.1152/ajpcell.00201.2009.

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Matriptase, a transmembrane serine protease, is broadly expressed by, and crucial for the integrity of, the epithelium. Matriptase is synthesized as a zymogen and undergoes autoactivation to become an active protease that is immediately inhibited by, and forms complexes with, hepatocyte growth factor activator inhibitor (HAI-1). To investigate where matriptase is activated and how it is secreted in vivo, we determined the expression and activation status of matriptase in seminal fluid and urine and the distribution and subcellular localization of the protease in the prostate and kidney. The in

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18

Danet-Desnoyers, G., C. Wetzels, and WW Thatcher. "Natural and recombinant bovine interferon tau regulate basal and oxytocin-induced secretion of prostaglandins F2 alpha and E2 by epithelial cells and stromal cells in the endometrium." Reproduction, Fertility and Development 6, no. 2 (1994): 193. http://dx.doi.org/10.1071/rd9940193.

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The effects of bovine interferon tau (IFN tau) and oxytocin on secretion of the prostaglandins PGF2 alpha and PGE2 by epithelial and stromal cells in the endometrium were assessed in two experiments. Endometrial tissues were collected from cyclic cows at Day 15 after oestrus for subsequent isolation of epithelial cells (4 cows) and stromal cells (4 cows). In both experiments, confluent cells were treated with 0, 2, 10 or 50 ng mL-1 natural bovine IFN tau (nbIFN tau) or 0, 0.4, 2, 10, 50 and 250 ng mL-1 recombinant bIFN tau (rbIFN tau). Culture medium was sampled at 24 h. Oxytocin (2.0 x 10(-7)

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19

Damkier, Helle H., Peter D. Brown, and Jeppe Praetorius. "Cerebrospinal Fluid Secretion by the Choroid Plexus." Physiological Reviews 93, no. 4 (2013): 1847–92. http://dx.doi.org/10.1152/physrev.00004.2013.

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The choroid plexus epithelium is a cuboidal cell monolayer, which produces the majority of the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins mediates the transepithelial movement of solutes and water across the epithelium. Secretion by the choroid plexus is characterized by an extremely high rate and by the unusual cellular polarization of well-known epithelial transport proteins. This review focuses on the specific ion and water transport by the choroid plexus cells, and then attempts to integrate the action of specific transport proteins to formulate a

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20

Sun, Zhaorui, Yajing Wang, Xuemin Gong, Hang Su, and Xiaodong Han. "Secretion of rat tracheal epithelial cells induces mesenchymal stem cells to differentiate into epithelial cells." Cell Biology International 36, no. 2 (2011): 169–75. http://dx.doi.org/10.1042/cbi20110121.

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21

Berin, M. Cecilia, Michael B. Dwinell, Lars Eckmann, and Martin F. Kagnoff. "Production of MDC/CCL22 by human intestinal epithelial cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 280, no. 6 (2001): G1217—G1226. http://dx.doi.org/10.1152/ajpgi.2001.280.6.g1217.

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The intestinal mucosa contains a subset of lymphocytes that produce Th2 cytokines, yet the signals responsible for the recruitment of these cells are poorly understood. Macrophage-derived chemokine (MDC/CCL22) is a recently described CC chemokine known to chemoattract the Th2 cytokine producing cells that express the receptor CCR4. The studies herein demonstrate the constitutive production of MDC/CCL22 in vivo by human colon epithelium and by epithelium of human intestinal xenografts. MDC/CCL22 mRNA expression and protein secretion was upregulated in colon epithelial cell lines in response to

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22

Vidalain, Pierre-Olivier, David Laine, Yona Zaffran, et al. "Interferons Mediate Terminal Differentiation of Human Cortical Thymic Epithelial Cells." Journal of Virology 76, no. 13 (2002): 6415–24. http://dx.doi.org/10.1128/jvi.76.13.6415-6424.2002.

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ABSTRACT In the thymus, epithelial cells comprise a heterogeneous population required for the generation of functional T lymphocytes, suggesting that thymic epithelium disruption by viruses may compromise T-cell lymphopoiesis in this organ. In a previous report, we demonstrated that in vitro, measles virus induced differentiation of cortical thymic epithelial cells as characterized by (i) cell growth arrest, (ii) morphological and phenotypic changes, and (iii) apoptotis as a final step of this process. In the present report, we have analyzed the mechanisms involved. First, measles virus-induce

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23

Johnson, Raymond M. "Murine Oviduct Epithelial Cell Cytokine Responses to Chlamydia muridarum Infection Include Interleukin-12-p70 Secretion." Infection and Immunity 72, no. 7 (2004): 3951–60. http://dx.doi.org/10.1128/iai.72.7.3951-3960.2004.

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ABSTRACT Epithelial cells play an important role in host defense as sentinels for invading microbial pathogens. Chlamydia trachomatis is an intracellular bacterial pathogen that replicates in reproductive tract epithelium. Epithelial cells lining the reproductive tract likely play a key role in triggering inflammation and adaptive immunity during Chlamydia infections. For this report a murine oviduct epithelial cell line was derived in order to determine how epithelial cells influence innate and adaptive immune responses during Chlamydia infections. As expected, oviduct epithelial cells infect

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24

Faherty, Christina S., and Anthony T. Maurelli. "Spa15 of Shigella flexneri Is Secreted through the Type III Secretion System and Prevents Staurosporine-Induced Apoptosis." Infection and Immunity 77, no. 12 (2009): 5281–90. http://dx.doi.org/10.1128/iai.00800-09.

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ABSTRACT Shigella flexneri is a gram-negative, facultative intracellular pathogen that invades the colonic epithelium and causes bacillary dysentery. We previously demonstrated that S. flexneri inhibits staurosporine-induced apoptosis in infected epithelial cells and that a ΔmxiE mutant is unable to inhibit apoptosis. Therefore, we hypothesized that an MxiE-regulated gene was responsible for protection of epithelial cells from apoptosis. Analysis of all MxiE-regulated genes yielded no mutants that lacked the ability to prevent apoptosis. Spa15, which is defined as a type III secretion system c

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25

Devor, Daniel C., Ashvani K. Singh, Linda C. Lambert, Arthur DeLuca, Raymond A. Frizzell, and Robert J. Bridges. "Bicarbonate and Chloride Secretion in Calu-3 Human Airway Epithelial Cells." Journal of General Physiology 113, no. 5 (1999): 743–60. http://dx.doi.org/10.1085/jgp.113.5.743.

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Serous cells are the predominant site of cystic fibrosis transmembrane conductance regulator expression in the airways, and they make a significant contribution to the volume, composition, and consistency of the submucosal gland secretions. We have employed the human airway serous cell line Calu-3 as a model system to investigate the mechanisms of serous cell anion secretion. Forskolin-stimulated Calu-3 cells secrete HCO−3 by a Cl −-independent, serosal Na+-dependent, serosal bumetanide-insensitive, and serosal 4,4′-dinitrostilben-2,2′-disulfonic acid (DNDS)–sensitive, electrogenic mechanism a

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26

Xu, Jian-Bang, Shen-Jiao Lu, Li-Jiao Ke, et al. "Trichomonas vaginalis infection impairs anion secretion in vaginal epithelium." PLOS Neglected Tropical Diseases 15, no. 4 (2021): e0009319. http://dx.doi.org/10.1371/journal.pntd.0009319.

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Trichomonas vaginalis is a common protozoan parasite, which causes trichomoniasis associated with severe adverse reproductive outcomes. However, the underlying pathogenesis has not been fully understood. As the first line of defense against invading pathogens, the vaginal epithelial cells are highly responsive to environmental stimuli and contribute to the formation of the optimal luminal fluid microenvironment. The cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel widely distributed at the apical membrane of epithelial cells, plays a crucial role in mediating the se

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27

Simpson Haidaris, Patricia J. "Induction of Fibrinogen Biosynthesis and Secretion From Cultured Pulmonary Epithelial Cells." Blood 89, no. 3 (1997): 873–82. http://dx.doi.org/10.1182/blood.v89.3.873.

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Abstract Although the liver is the primary site of fibrinogen (FBG) synthesis, epithelial cells from diverse tissues have been shown to express one or more of the FBG Aα, Bβ, and γ chain genes. In contrast, marrow megakaryocytes, which store FBG in the α-granules, are thought not to express the FBG genes. Our earlier studies have shown that epithelial cells in a variety of extrahepatic tissues express the γ chain gene ubiquitously, while the mRNAs for the Aα and Bβ chain genes are essentially undetectable. During systemic inflammation, the liver secretes increased levels of FBG into the circul

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28

Hu, Jianbo, Gheorghe T. Braileanu та Mark A. Mirando. "Effect of ovarian steroids on basal and oxytocin-induced prostaglandin F2α secretion from pig endometrial cells". Reproduction, Fertility and Development 15, № 4 (2003): 197. http://dx.doi.org/10.1071/rd03024.

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These studies were undertaken to determine how treatment with 100 nM progesterone and/or 10 nM oestradiol-17β acutely (3 h; Experiment 1) or chronically (72 h; Experiments 2–4) influenced basal and oxytocin (OT)-stimulated prostaglandin (PG) F2α secretion, in enriched cultures of pig endometrial luminal epithelial, glandular epithelial and stromal cells obtained on Day 16 (Experiments 1, 2 and 4) or Day 12 (Experiment 3) after oestrus. In Experiment 1, acute treatment with progesterone stimulated PGF2α secretion from each cell type on Day 16, whereas acute oestradiol treatment inhibited the st

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29

Cheung, CH, EW Moore, JB Prystowsky та RV Rege. "TNFα stimulates mucus secretion in gallbladder epithelial cells". Gastroenterology 114 (квітень 1998): A1225. http://dx.doi.org/10.1016/s0016-5085(98)84969-x.

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30

McGahan, M. C., J. Harned, M. Goralska, B. Sherry, and L. N. Fleisher. "Transferrin secretion by lens epithelial cells in culture." Experimental Eye Research 60, no. 6 (1995): 667–73. http://dx.doi.org/10.1016/s0014-4835(05)80008-9.

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31

Cowley, Elizabeth A. "Isoprostane-Mediated Secretion from Human Airway Epithelial Cells." Molecular Pharmacology 64, no. 2 (2003): 298–307. http://dx.doi.org/10.1124/mol.64.2.298.

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TANI, Satoru, Masaki OKUDA, Rie MORISHIGE, and Toru TANAKA. "Gastric Mucin Secretion from Cultured Rat Epithelial Cells." Biological & Pharmaceutical Bulletin 20, no. 5 (1997): 482–85. http://dx.doi.org/10.1248/bpb.20.482.

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Becker, Marie N., Mariam S. Sauer, Marianne S. Muhlebach, et al. "Cytokine Secretion by Cystic Fibrosis Airway Epithelial Cells." American Journal of Respiratory and Critical Care Medicine 169, no. 5 (2004): 645–53. http://dx.doi.org/10.1164/rccm.200207-765oc.

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34

Guadiz, Gayle, Lee Ann Sporn, Rachel A. Goss, Sarah O. Lawrence, Victor J. Marder, and Patricia J. Simpson-Haidaris. "Polarized Secretion of Fibrinogen by Lung Epithelial Cells." American Journal of Respiratory Cell and Molecular Biology 17, no. 1 (1997): 60–69. http://dx.doi.org/10.1165/ajrcmb.17.1.2730.

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35

Öztay, Füsun. "The responses of pulmonary neuroendocrine cells in the lungs of Rana ridibunda to different experimental conditions." Animal Biology 56, no. 3 (2006): 373–82. http://dx.doi.org/10.1163/157075606778441859.

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AbstractThe study investigated the localisation and immunohistochemistry of neuroendocrine cells (PNECs) and their behaviour in the lungs of Rana ridibunda under experimental conditions and compared with control lungs. Serotonin- and bombesin-immunoreactive (IR) PNECs were observed as solitary cells or clusters of cells at the base of ciliated epithelium on the dilated apical parts of primary septa where incoming air first arrives, and in the respiratory epithelium. Serotonin-IR PNECs were predominantly present in the ciliated epithelium while bombesin-IR PNECs were found in the ciliated and r

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36

Bland, R. D. "Lung epithelial ion transport and fluid movement during the perinatal period." American Journal of Physiology-Lung Cellular and Molecular Physiology 259, no. 2 (1990): L30—L37. http://dx.doi.org/10.1152/ajplung.1990.259.2.l30.

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During fetal life, the mammalian lung is a secretory organ that serves no respiratory function. Its potential airspaces are filled with liquid that flows from the pulmonary circulation across the epithelium in response to the osmotic force generated by Cl- secretion of airway and distal lung epithelial cells. As birth approaches, net Cl- secretion across the respiratory tract epithelium decreases, and this is associated with a reduction in the flow of liquid into the lung lumen. The cause for this change is unknown, but several recent studies indicate that it may be related to alterations in t

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37

Chang, Mary Mann-Jong, Reen Wu, Charles G. Plopper, and Dallas M. Hyde. "IL-8 is one of the major chemokines produced by monkey airway epithelium after ozone-induced injury." American Journal of Physiology-Lung Cellular and Molecular Physiology 275, no. 3 (1998): L524—L532. http://dx.doi.org/10.1152/ajplung.1998.275.3.l524.

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A rhesus monkey interleukin (IL)-8 cDNA clone with >94% homology to the human IL-8 gene was isolated by differential hybridization from a cDNA library of distal airways after ozone inhalation. In situ hybridization and immunohistochemistry showed increased IL-8 mRNA and protein levels in epithelial cells at 1 h but not at 24 h after inhalation of ozone. The appearance of IL-8 in airway epithelial cells correlated well with neutrophil influx into airway epithelia and lumens. Air-liquid interface cultures of tracheobronchial epithelial cells were exposed to ozone in vitro. We observed a trans

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Carson, D. D., J. P. Tang, J. Julian, and S. R. Glasser. "Vectorial secretion of proteoglycans by polarized rat uterine epithelial cells." Journal of Cell Biology 107, no. 6 (1988): 2425–35. http://dx.doi.org/10.1083/jcb.107.6.2425.

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We have studied proteoglycan secretion using a recently developed system for the preparing of polarized primary cultures of rat uterine epithelial cells. To mimic their native environment better and provide a system for discriminating apical from basolateral compartments, we cultured cells on semipermeable supports impregnated with biomatrix. Keratan sulfate proteoglycans (KSPG) as well as heparan sulfate-containing molecules (HS[PG]) were the major sulfated products synthesized and secreted by these cells. The ability of epithelial cells to secrete KSPG greatly increased in parallel with the

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KLINKSPOOR, J. Henriëtte, Guido N. J. TYTGAT, Sum P. LEE, and Albert K. GROEN. "Mechanism of bile salt-induced mucin secretion by cultured dog gallbladder epithelial cells." Biochemical Journal 316, no. 3 (1996): 873–77. http://dx.doi.org/10.1042/bj3160873.

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1. Hypersecretion of gallbladder mucin has been proposed to be a pathogenic factor in cholesterol gallstone formation. Using cultured gallbladder epithelial cells, we demonstrated that bile salts regulate mucin secretion by the gallbladder epithelium. In the present study we have investigated whether established second messenger pathways are involved in bile salt-induced mucin secretion. 2. The effect of activators and inhibitors on mucin secretion was studied by measuring the secretion of [3H]N-acetyl-D-glucosamine-labelled glycoproteins. Intracellular cAMP content of the cells was measured u

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McLaughlin, Charles W., David Peart, Robert D. Purves, et al. "Timolol may inhibit aqueous humor secretion by cAMP-independent action on ciliary epithelial cells." American Journal of Physiology-Cell Physiology 281, no. 3 (2001): C865—C875. http://dx.doi.org/10.1152/ajpcell.2001.281.3.c865.

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The β-adrenergic antagonist timolol reduces ciliary epithelial secretion in glaucomatous patients. Whether inhibition is mediated by reducing cAMP is unknown. Elemental composition of rabbit ciliary epithelium was studied by electron probe X-ray microanalysis. Volume of cultured bovine pigmented ciliary epithelial (PE) cells was measured by electronic cell sizing; Ca2+ activity and pH were monitored with fura 2 and 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein, respectively. Timolol (10 μM) produced similar K and Cl losses from ciliary epithelia in HCO[Formula: see text]/CO2 solution but h

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Giraud, Olivier, Serge Molliex, Corinne Rolland та ін. "Halogenated Anesthetics Reduce Interleukin-1β-induced Cytokine Secretion by Rat Alveolar Type II Cells in Primary Culture". Anesthesiology 98, № 1 (2003): 74–81. http://dx.doi.org/10.1097/00000542-200301000-00015.

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Background Alveolar epithelial type II (AT II ) cells participate in the intraalveolar cytokine network by secreting cytokines and are widely exposed to volatile anesthetics during general anesthesia. The aim of the current study was to evaluate the effects of halothane, enflurane, and isoflurane on rat AT II cell cytokine secretions in AT II primary cell cultures. Methods Alveolar epithelial type II primary cell cultures were obtained from adult rat lungs. AT II cells were stimulated by recombinant murine interleukin-1beta (rmIL-1beta) to mimic an inflammatory response, and immediately expose

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KLINKSPOOR, J. Henriëtte, Tadashi YOSHIDA, and Sum P. LEE. "Bile salts stimulate mucin secretion by cultured dog gallbladder epithelial cells independent of their detergent effect." Biochemical Journal 332, no. 1 (1998): 257–62. http://dx.doi.org/10.1042/bj3320257.

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1. Bile salts stimulate mucin secretion by the gallbladder epithelium. We have investigated whether this stimulatory effect is due to a detergent effect of bile salts. 2. The bile salts taurocholic acid (TC) and tauroursodeoxycholic acid (TUDC) and the detergents Triton X-100 (12.5–400 µM) and Tween-20 (0.1–3.2 mM) were applied to monolayers of cultured dog gallbladder epithelial cells. Mucin secretion was studied by measuring the secretion of [3H]N-acetyl-d-glucosamine-labelled glycoproteins. We also attempted to alter the fluidity of the apical membrane of the cells through extraction of cho

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McCray, P. B., and M. J. Welsh. "Developing fetal alveolar epithelial cells secrete fluid in primary culture." American Journal of Physiology-Lung Cellular and Molecular Physiology 260, no. 6 (1991): L494—L500. http://dx.doi.org/10.1152/ajplung.1991.260.6.l494.

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The developing pulmonary epithelium secretes a Cl(-)-rich fluid during fetal life by a process involving active transport. To determine if alveolar cells contribute to this fluid production, we studied developing fetal rat alveolar epithelial cells (18-day gestation) in primary culture. Fetal alveolar epithelial cells aggregated to form cystic, alveolar-like structures with a fluid-filled lumen. On light and transmission electron microscopy, the cells were polarized with microvilli facing the lumen. Dexamethasone and triiodothyronine stimulated lamellar body production in many of the epithelia

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Kreindler, James L., Alan D. Jackson, Philip A. Kemp, Robert J. Bridges, and Henry Danahay. "Inhibition of chloride secretion in human bronchial epithelial cells by cigarette smoke extract." American Journal of Physiology-Lung Cellular and Molecular Physiology 288, no. 5 (2005): L894—L902. http://dx.doi.org/10.1152/ajplung.00376.2004.

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Chronic bronchitis, a disease mainly of cigarette smokers, shares many clinical features with cystic fibrosis, a disease of altered ion transport, suggesting that the negative effects of cigarette smoke on mucociliary clearance may be mediated through alterations in ion transport. We tested the hypothesis that cigarette smoke extract would inhibit chloride secretion in human bronchial epithelial cells. In agreement with studies in canine trachea, cigarette smoke extract inhibited net chloride secretion without affecting sodium transport. We performed microelectrode impalements and impedance an

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Alcala, S., A. Benton, A. Watson, et al. "22: MITOTIC ASYNCHRONY INDUCES A PRO-INFLAMMATORY STATE IN AIRWAY EPITHELIUM." Journal of Investigative Medicine 64, no. 3 (2016): 816.1–816. http://dx.doi.org/10.1136/jim-2016-000080.38.

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Purpose of StudyMitotic behaviors are likely important for maintaining and restoring homeostasis in lung diseases with epithelial injury. We recently proposed that regenerative asynchrony in repairing tissue may underlie chronic inflammation and fibrosis, where immune cell infiltration is secondary to pro-inflammatory cross-talk among asynchronously repairing adjacent tissues. Building on our previous finding that regenerative asynchrony is associated with pro-inflammatory/fibrotic cytokine secretion, here we provide proof of cause-and-effect.Methods UsedIn vitro experiments were performed whe

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Colgan, S. P., C. A. Parkos, J. B. Matthews, et al. "Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells." American Journal of Physiology-Cell Physiology 267, no. 2 (1994): C402—C410. http://dx.doi.org/10.1152/ajpcell.1994.267.2.c402.

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Intestinal epithelia are in intimate contact with submucosal and intraepithelial lymphocytes. The concentration of intraepithelial lymphocytes increases during inflammatory processes, and, when stimulated, these cells generate cytokines such as interferon-gamma (IFN-gamma). In this study, we examined the effect of recombinant human IFN-gamma on ion transport events in T84 cells, a crypt epithelial cell line widely used to study electrogenic Cl- secretion, the transport event responsible for mucosal hydration. Epithelial exposure to IFN-gamma brought about a marked attenuation in stimulated Cl-

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Uzumcu, Mehmet, Kevin G. Carnahan, Gheorghe T. Braileanu та Mark A. Mirando. "Oxytocin-stimulated phosphoinositide hydrolysis and prostaglandin F2α secretion by luminal epithelial, glandular epithelial and stromal cells from pig endometrium. II. Responses of cyclic, pregnant and pseudopregnant pigs on Days 12 and 1". Reproduction, Fertility and Development 12, № 4 (2000): 157. http://dx.doi.org/10.1071/rd00084.

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In pigs, the exact mechanism for the shift in endometrial PGF 2α secretion from an endocrine to an exocrine mode during pregnancy recognition is not known. The objective of this study was to examine whether this shift involved a change in the responsiveness of luminal epithelial, glandular epithelial and stromal cells to 0 or 100 nM oxytocin. Luminal epithelial cells, glandular epithelial cells and stromal cells were isolated from cyclic, pregnant or oestrogen-induced pseudopregnant gilts on Day 12 (Experiment 1) or Day 16 (Experiment 2) post oestrus (oestrus = Day 0). For cells obtained on Da

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Nishimura, Akiyoshi, Mika Fujimoto, Satoshi Oguchi, Robert D. Fusunyan, Richard P. MacDermott, and Ian R. Sanderson. "Short-chain fatty acids regulate IGF-binding protein secretion by intestinal epithelial cells." American Journal of Physiology-Endocrinology and Metabolism 275, no. 1 (1998): E55—E63. http://dx.doi.org/10.1152/ajpendo.1998.275.1.e55.

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Gastrointestinal epithelial cells secrete insulin-like growth factor (IGF)-binding proteins (IGFBPs), which modulate the actions of IGFs on cell proliferation and differentiation. Short-chain fatty acids are bacterial metabolites from unabsorbed carbohydrate (including fiber). We hypothesized that they may alter the pattern of IGFBPs secreted by epithelial cells as part of a wider phenomenon by which luminal molecules regulate gastrointestinal epithelial cell signaling. The intestinal epithelial cell line, Caco-2, predominantly secretes IGFBP-3; however, butyrate increased the secretion of IGF

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al-Nakkash, L., and C. U. Cotton. "Bovine pancreatic duct cells express cAMP- and Ca(2+)-activated apical membrane Cl- conductances." American Journal of Physiology-Gastrointestinal and Liver Physiology 273, no. 1 (1997): G204—G216. http://dx.doi.org/10.1152/ajpgi.1997.273.1.g204.

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Secretion of salt and water by the epithelial cells that line pancreatic ducts depends on activation of apical membrane Cl- conductance. In the present study, we characterized two types of Cl- conductances present in the apical cell membrane of bovine pancreatic duct epithelial cells. Primary cultures of bovine main pancreatic duct epithelium and an immortalized cell line (BPD1) derived from primary cultures were used. Elevation of intracellular adenosine 3',5'-cyclic monophosphate (cAMP) or Ca2+ in intact monolayers of duct epithelium induced sustained anion secretion. Agonist-induced changes

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Schulte, Ralf, and Ingo B. Autenrieth. "Yersinia enterocolitica-Induced Interleukin-8 Secretion by Human Intestinal Epithelial Cells Depends on Cell Differentiation." Infection and Immunity 66, no. 3 (1998): 1216–24. http://dx.doi.org/10.1128/iai.66.3.1216-1224.1998.

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ABSTRACT In response to bacterial entry epithelial cells up-regulate expression and secretion of various proinflammatory cytokines, including interleukin-8 (IL-8). We studied Yersinia enterocolitica O:8-induced IL-8 secretion by intestinal epithelial cells as a function of cell differentiation. For this purpose, human T84 intestinal epithelial cells were grown on permeable supports, which led to the formation of tight monolayers of polarized intestinal epithelial cells. To analyze IL-8 secretion as a function of cell differentiation, T84 monolayers were infected from the apical or basolateral

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