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Journal articles on the topic 'Epithelioid and Spindle Cell Nevus'

Author: Grafiati

Published: 27 July 2024

Last updated: 31 July 2025

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1

Kaye, Valda N. "Spindle and Epithelioid Cell Nevus (Spitz Nevus)." Archives of Dermatology 126, no. 12 (1990): 1581. http://dx.doi.org/10.1001/archderm.1990.01670360045005.

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2

Suster, Saul. "Hyalinizing Spindle and Epithelioid Cell Nevus." American Journal of Dermatopathology 16, no. 6 (1994): 593–98. http://dx.doi.org/10.1097/00000372-199412000-00004.

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3

M�rot, Yves, and Edgar Frenk. "Spitz nevus (large spindle cell and/or epithelioid cell nevus)." Virchows Archiv A Pathological Anatomy and Histopathology 415, no. 2 (1989): 97–101. http://dx.doi.org/10.1007/bf00784346.

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4

Kaye, V. N. "Spindle and epithelioid cell nevus (Spitz nevus). Natural history following biopsy." Archives of Dermatology 126, no. 12 (1990): 1581–83. http://dx.doi.org/10.1001/archderm.126.12.1581.

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5

Liu, Jing, Philip R. Cohen, and Anwar Farhood. "Hyalinizing Spitz Nevus: Spindle and Epithelioid Cell Nevus with Paucicellular Collagenous Stroma." Southern Medical Journal 97, no. 1 (2004): 102–6. http://dx.doi.org/10.1097/01.smj.0000055103.97445.ab.

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6

Yoradjian, Alessandra, Mílvia Maria Simões e. Silva Enokihara, and Francisco Macedo Paschoal. "Spitz nevus and Reed nevus." Anais Brasileiros de Dermatologia 87, no. 3 (2012): 349–59. http://dx.doi.org/10.1590/s0365-05962012000300001.

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Spitz and Reed nevi, also called spindle and/or epithelioid cell nevi, are a special group of melanocytic lesions due to their peculiar clinical, dermoscopic and histopathological features. The study of these nevi is of great interest because both their nomenclature and classification are still a matter of discussion. Most importantly, the difficulty to differentiate them from melanoma can lead to inadequate therapies. In this context, dermoscopy, a link between clinical and anatomopathological examinations, appears as a helpful diagnostic tool whose accuracy can reach 93%. "Borderline" lesion

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7

Lopes, Jorge, David Afonso-João, Diogo Teixeira, and Armando Baptista. "Angiomatoid Spitz Nevus." Journal of the Portuguese Society of Dermatology and Venereology 78, no. 4 (2020): 377–79. http://dx.doi.org/10.29021/spdv.78.4.1245.

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Angiomatoid Spitz nevus is a rare tumor that combines the classic aspects of Spitz nevus with a prominent vascular component. Clinically, it presents as a pink or brownish papule, usually solitary, in the extremities of young adults. On histology, it is characterized by a proliferation of epithelioid or spindle cell melanocytes embedded in a fibrous stroma, where a dense proliferation of small vessels is evident. The differential diagnosis with malignant melanoma can be difficult, particularly with the desmoplastic variant or with those with marked regression. Its behavior is benign, as sugges

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8

Dal Pozzo, V., C. Benelli, L. Restano, R. Gianotti, and B. M. Cesana. "Clinical Review of 247 Case Records of Spitz Nevus (Epithelioid Cell and/or Spindle Cell Nevus)." Dermatology 194, no. 1 (1997): 20–25. http://dx.doi.org/10.1159/000246051.

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9

Teh, Ming, and Raja Sinniah. "Spindle and epithelioid cell nevus of tongue at an unusual site." Oral Surgery, Oral Medicine, Oral Pathology 67, no. 1 (1989): 68–72. http://dx.doi.org/10.1016/0030-4220(89)90304-6.

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10

Smith, Kathleen J., Terry L. Barrett, Henry G. Skelton, George P. Lupton, and James H. Graham. "Spindle Cell and Epithelioid Cell Nevi with Atypia and Metastasis (Malignant Spitz Nevus)." American Journal of Surgical Pathology 13, no. 11 (1989): 931–39. http://dx.doi.org/10.1097/00000478-198911000-00003.

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11

Tamrazova, O. B., V. Y. Sergeev, V. G. Nikitaev, A. V. Taganov, E. A. Glukhova, and A. N. Pronichev. "SPITZ NEVUS (JUVENILE MELANOMA) IN THE PEDIATRICIANS PRACTICE: CLINICAL PICTURE, DIAGNOSIS, PROGNOSIS AND TREATMENT." Pediatria. Journal named after G.N. Speransky 100, no. 1 (2021): 166–72. http://dx.doi.org/10.24110/0031-403x-2021-100-1-166-172.

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Spitz nevi (epithelioid and spindle-cell nevi) are a special group of melanocytic neoplasms with a specific clinical, dermatoscopic and histological picture. There are typical and atypical Spitz nevus. The typical Spitz nevus is more common in pediatric practice and has a benign course. Of particular interest are atypical forms that combine the characteristics of a typical Spitz nevus and melanoma. The article presents an analysis of the clinical picture, dermatoscopic, immunohistochemical, histological and genetic characteristics in various forms of Spitz nevus. The existing classification ac

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12

Sakamoto, F., M. Ito, and Y. Sato. "Ultrastructural study of nuclear inclusions in spindle and epithelioid cell nevus cells." Journal of Cutaneous Pathology 17, no. 2 (1990): 82–86. http://dx.doi.org/10.1111/j.1600-0560.1990.tb00061.x.

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13

Merot, Y. "Transepidermal elimination of nevus cells in spindle and epithelioid cell (Spitz) nevi." Archives of Dermatology 124, no. 9 (1988): 1441–42. http://dx.doi.org/10.1001/archderm.124.9.1441.

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14

Merot, Yves. "Transepidermal Elimination of Nevus Cells in Spindle and Epithelioid Cell (Spitz) Nevi." Archives of Dermatology 124, no. 9 (1988): 1441. http://dx.doi.org/10.1001/archderm.1988.01670090083022.

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15

Sakamoto, F., M. Ito, and Y. Sato. "Ultrastructural study of macromelanosomes in a unique case of spindle and epithelioid cell nevus." Journal of Cutaneous Pathology 14, no. 1 (1987): 59–64. http://dx.doi.org/10.1111/j.1600-0560.1987.tb00128.x.

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16

WONG, T. "Nevoid melanoma: A clinicopathological study of seven cases of malignant melanoma mimicking spindle and epithelioid cell nevus and verrucous dermal nevus." Human Pathology 26, no. 2 (1995): 171–79. http://dx.doi.org/10.1016/0046-8177(95)90034-9.

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17

Cockerell, Clay J. "Nevoid melanoma: a clinicopathologic study of seven cases of malignant melanoma mimicking spindle and epithelioid cell nevus and verrucous dermal nevus." Journal of the American Academy of Dermatology 33, no. 5 (1995): 811. http://dx.doi.org/10.1016/0190-9622(95)91835-3.

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18

Argenziano, Giuseppe, H. Peter Soyer, Gerardo Ferrara, et al. "Superficial Black Network: An Additional Dermoscopic Clue for the Diagnosis of Pigmented Spindle and/or Epithelioid Cell Nevus." Dermatology 203, no. 4 (2001): 333–35. http://dx.doi.org/10.1159/000051784.

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19

URABE, Atsumichi, Tetsuo MATSUDA, and Masakazu ASAHI. "Pigmented spindle cell nevus." Nishi Nihon Hifuka 49, no. 6 (1987): 1022–25. http://dx.doi.org/10.2336/nishinihonhifu.49.1022.

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20

Díaz, Alba, Alexandra Valera, Cristina Carrera, et al. "Pigmented Spindle Cell Nevus." American Journal of Surgical Pathology 35, no. 11 (2011): 1733–42. http://dx.doi.org/10.1097/pas.0b013e318229cf66.

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21

Pellacani, G., AM Cesinaro, and S. Seidenari. "Morphological features of Spitz naevus as observed by digital videomicroscopy." Acta Dermato-Venereologica 80, no. 2 (2000): 117–21. http://dx.doi.org/10.2340/0001555580122126.

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A characteristic epiluminescence pattern of pigmented epithelioid and/or spindle cell naevus, or Spitz naevus, has been described previously. The aim of this study was (i) to evaluate the characteristic morphological features both of pigmented and non-pigmented epithelioid and/or spindle cell naevi observed employing a videomicroscope, (ii) to identify their histopathological correlates and (iii) to assess the improvement in diagnostic accuracy for epithelioid and/or spindle cell naevi obtained by means of this new instrumental device. Clinical, videomicroscopic and histopathological diagnoses

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22

Zelger, Bettina G., Beatrix Wambacher, Hansjörg Steiner, and Bernhard Zelger. "Cutaneous epithelioid hemangioendothelioma, epithelioid cell histiocytoma and Spitz nevus." Journal of Cutaneous Pathology 24, no. 10 (1997): 641–47. http://dx.doi.org/10.1111/j.1600-0560.1997.tb01096.x.

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23

Choi, Jee Ho, Kyung Jeh Sung, and Jai Kyoung Koh. "Pigmented epithelioid cell nevus: A variant of Spitz nevus?" Journal of the American Academy of Dermatology 28, no. 3 (1993): 497–98. http://dx.doi.org/10.1016/s0190-9622(08)81765-3.

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24

Shields, J. A., D. S. Karan, H. D. Perry, and L. A. Donoso. "Epithelioid Cell Nevus of the Iris." Archives of Ophthalmology 103, no. 2 (1985): 235–37. http://dx.doi.org/10.1001/archopht.1985.01050020087028.

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25

Burg, Guenter, Werner Kempf, Matthias Hochli, Toni Huwyler, and Renato G. Panizzon. "'Tubular' epithelioid cell nevus: a new variant of Spitz's nevus." Journal of Cutaneous Pathology 25, no. 9 (1998): 475–78. http://dx.doi.org/10.1111/j.1600-0560.1998.tb01778.x.

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26

Murigu, Timothy, Nidhi Bhatt, Keith Miller, Abigail Palmer, and Zsombor Melegh. "Spindle cell-predominant epithelioid fibrous histiocytoma." Histopathology 72, no. 7 (2018): 1233–36. http://dx.doi.org/10.1111/his.13484.

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27

Keel, Suzanne B., and Andrew E. Rosenberg. "Hemorrhagic epithelioid and spindle cell hemangioma." Cancer 85, no. 9 (1999): 1966–72. http://dx.doi.org/10.1002/(sici)1097-0142(19990501)85:9%3c1966::aid-cncr13%3e3.0.co;2-w.

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28

Keel, Suzanne B., and Andrew E. Rosenberg. "Hemorrhagic epithelioid and spindle cell hemangioma." Cancer 85, no. 9 (1999): 1966–72. http://dx.doi.org/10.1002/(sici)1097-0142(19990501)85:9<1966::aid-cncr13>3.0.co;2-w.

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29

Hiscott, Paul, Berthold Seitz, and Gottfried O. H. Naumann. "Epithelioid cell spitz nevus of the eyelid." American Journal of Ophthalmology 126, no. 5 (1998): 735–37. http://dx.doi.org/10.1016/s0002-9394(98)00141-x.

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30

Pusiol, Teresa, Ilaria Franceschetti, Francesco Piscioli, and Maria Grazia Zorzi. "Epithelioid cell histiocytoma and neurotized melanocytic nevus." International Journal of Dermatology 50, no. 10 (2011): 1298–99. http://dx.doi.org/10.1111/j.1365-4632.2010.04484.x.

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31

Cooper, Philip H. "Deep penetrating (plexiform spindle cell) nevus." Journal of Cutaneous Pathology 19, no. 3 (1992): 172–80. http://dx.doi.org/10.1111/j.1600-0560.1992.tb01655.x.

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32

Jin, Zhao-hui, Masanobu Kumakiri, Hisaya Ishida, and Shoichi Kinebuchi. "A Case of Combined Nevus: Compound Nevus and Spindle Cell Spitz Nevus." Journal of Dermatology 27, no. 4 (2000): 233–37. http://dx.doi.org/10.1111/j.1346-8138.2000.tb02157.x.

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33

Foti, Pietro Valerio, Corrado Inì, Giuseppe Broggi, et al. "Quantitative Diffusion-Weighted MR Imaging: Is There a Prognostic Role in Noninvasively Predicting the Histopathologic Type of Uveal Melanomas?" Cancers 15, no. 23 (2023): 5627. http://dx.doi.org/10.3390/cancers15235627.

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Histopathologically, uveal melanomas (UMs) can be classified as spindle cell, mixed cell and epithelioid cell type, with the latter having a more severe prognosis. The aim of our study was to assess the correlation between the apparent diffusion coefficient (ADC) and the histologic type of UMs in order to verify the role of diffusion-weighted magnetic resonance imaging (DWI) as a noninvasive prognostic marker. A total of 26 patients with UMs who had undergone MRI and subsequent primary enucleation were retrospectively selected. The ADC of the tumor was compared with the histologic type. The da

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34

Maclean, Fiona M., Julie Schatz, Stanley W. McCarthy, Richard A. Scolyer, Paul Stalley, and S. Fiona Bonar. "Epithelioid and spindle cell haemangioma of bone." Skeletal Radiology 36, S1 (2007): 50–57. http://dx.doi.org/10.1007/s00256-006-0135-z.

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35

Rebolleda, G., M. Suárez Figueroa, F. J. Muñoz-Negrete, and A. Rocamora. "Magnetic Resonance Imaging in Cavitary Choroidal Melanoma." European Journal of Ophthalmology 10, no. 4 (2000): 335–37. http://dx.doi.org/10.1177/112067210001000412.

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Purpose To report the development of a cavitary choroidal melanoma in a patient with nevus of Ota and describe its magnetic resonance imaging (MRI) features. Patient A 66-year-old man with right oculodermal melanocytosis and an ipsilateral choroidal cavitary melanoma was seen. Diagnosis was suspected on the clinical, ultrasonographic and MRI findings. Results T1-weighted image showed a hyperintense solid mass containing hypointense cystic-like spaces delineated by hyperintense septa with respect to the vitreous. The reverse image was observed on T2-weighted images. A choroidal melanoma compris

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36

Wistuba, Ivan, and Sergio Gonzalez. "Eosinophilic Globules in Pigmented Spindle Cell Nevus." American Journal of Dermatopathology 12, no. 3 (1990): 268–71. http://dx.doi.org/10.1097/00000372-199006000-00007.

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37

Kanteti, A. P., and E. Martinez Duarte. "A Rare Case of Dedifferentiated Solitary Fibrous Tumor." American Journal of Clinical Pathology 154, Supplement_1 (2020): S42. http://dx.doi.org/10.1093/ajcp/aqaa161.089.

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Abstract Casestudy: Dedifferentiated solitary fibrous tumor is a rare malignant subtype of the common benign mesenchymal neoplasm with fibroblastic differentiation known as solitary fibrous tumor (SFT). These account for less than 2% of all soft masses; and about 20% of SFTs turn aggressive. They feature bland spindle cells creating a classic “pattern-less pattern” in collagenous stroma with prominent staghorn vessels. They can dedifferentiate into a biphasic tumor with low grade areas that are spindle cell rich and high-grade areas with epithelioid cells, mitotic figures and necrosis. Here we

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38

Pumarola, M., S. Añor, D. Borràs, and I. Ferrer. "Malignant Epithelioid Schwannoma Affecting the Trigeminal Nerve of a Dog." Veterinary Pathology 33, no. 4 (1996): 434–36. http://dx.doi.org/10.1177/030098589603300411.

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A malignant epithelioid schwannoma was diagnosed affecting the trigeminal nerve of an 11-year-old dog. Neurologic abnormalities included an altered mental status, ataxia, left head tilt, postural reaction deficits of all four limbs, a pronounced left masticatory muscle atrophy, and absent left facial sensation. Histologically, a densely arranged epithelioid population with a very high mitotic index was surrounded by a spindle-shaped cell proliferation characteristic of schwannomas. Both cell populations stained positively for vimentin, but only spindle cells were occassionally positive for S-1

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39

Skelton, Henry G., Mathew L. Miller, George P. Lupton, and Kathleen J. Smith. "Eosinophilic Globules in Spindle Cell and Epithelioid Cell Nevi." American Journal of Dermatopathology 20, no. 6 (1998): 547–50. http://dx.doi.org/10.1097/00000372-199812000-00002.

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40

Stone, Chad H., Min W. Lee, Mahul B. Amin, et al. "Renal Angiomyolipoma." Archives of Pathology & Laboratory Medicine 125, no. 6 (2001): 751–58. http://dx.doi.org/10.5858/2001-125-0751-ra.

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Abstract Background.—Renal angiomyolipoma is a benign tumor histologically characterized by proliferation of spindle cells, epithelioid cells, and adipocytic cells in concert with many thick-walled blood vessels. To add further diagnostic confusion, an epithelioid cell–predominant variant of renal angiomyolipoma has recently been described. HMB-45 immunoreactivity correlates with ultrastructural striated organelles that closely resemble premelanosomes, although no evidence of melanogenesis has been documented in this tumor. Objective.—To further characterize the immunophenotypic and ultrastruc

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41

Zhou-Wei, Wu, Shi Wei-min, Sun Yue, Li Xiao-Jie, and Song Jun. "Cutaneous spindle cell squamous cell carcinoma in nevus sebaceous." International Journal of Dermatology 49, no. 12 (2010): 1429–31. http://dx.doi.org/10.1111/j.1365-4632.2010.04624.x.

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42

Hakim, Natalya, Yevgen Chornenkyy, and Shadi Qasem. "Malignant Perivascular Epithelioid Cell Tumor Mimicking Renal Cell Carcinoma: A Diagnostic Pitfall." American Journal of Clinical Pathology 152, Supplement_1 (2019): S62. http://dx.doi.org/10.1093/ajcp/aqz113.061.

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Abstract Introduction Perivascular epithelioid cell tumors (PEComas) are defined by the World Health Organization (WHO) as mesenchymal tumors arising from perivascular epithelioid cells with myomelanocytic immunophenotype. In the kidney, they are often referred to as epithelioid angimyolipoma (AML). Most are benign but some can be malignant. Their rarity and wide differential render diagnosis challenging. Case Presentation A 56-year-old male presented with a 3-month history of flank pain. Computed tomography (CT) identified bilateral necrotic heterogeneous enhancing kidney masses, with right s

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43

ZOLTIE, N., and P. F. ROBERTS. "Spindle cell haemangioendothelioma in association with epithelioid haemangioendothelioma." Histopathology 15, no. 5 (1989): 544–46. http://dx.doi.org/10.1111/j.1365-2559.1989.tb01616.x.

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44

Warraich, Irfan, Dale M. Dunn, and Jeffrey W. Oliver. "Solitary Fibrous Tumor of the Orbit With Epithelioid Features." Archives of Pathology & Laboratory Medicine 130, no. 7 (2006): 1039–41. http://dx.doi.org/10.5858/2006-130-1039-sftoto.

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Abstract Extrapleural solitary fibrous tumors have often been confused with other mesenchymal tumors, such as hemangiopericytoma, fibrous histiocytoma, fibrous meningioma, and leiomyoma, because of morphologic similarity and underrecognition, especially if some unusual features are present. Recently, epithelioid solitary fibrous tumor has been reported in the mediastinum. We report a case of solitary fibrous tumor of the orbit with biphasic architecture, including spindle cell and epithelioid components. Both components demonstrated immunohistochemical features of a solitary fibrous tumor. A b

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45

Nakamura, Yoshitaka, Akiko Nakamura, and Masahiko Muto. "Solitary Spindle Cell Xanthogranuloma Mimicking a Spitz Nevus." American Journal of Dermatopathology 35, no. 8 (2013): 865–67. http://dx.doi.org/10.1097/dad.0b013e3182840d2d.

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46

van der Linde-Sipman, J. S., M. M. L. de Wit, E. van Garderen, R. F. Molenbeek, D. van der Velde-Zimmermann, and R. A. de Weger. "Cutaneous Malignant Melanomas in 57 Cats: Identification of (Amelanotic) Signet-ring and Balloon Cell Types and Verification of Their Origin by Immunohistochemistry, Electron Microscopy, and In Situ Hybridization." Veterinary Pathology 34, no. 1 (1997): 31–38. http://dx.doi.org/10.1177/030098589703400105.

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Cutancous malignant melanomas in cats, both melanotic and amelanotic, were diagnosed in 57 of 1,530 skin tumors during the period 1991-1995. All melanomas occurred in domestic shorthaircats of ages 3-19 years ( $X = 11.5 years). Postmortem examination was performed on 16 cats. All had metastases in the regional lymph node and several organ systems. The average time of survival after surgical removal of the tumor was 4.5 months. Histologically, five types of melanomas could be distinguished: epithelioid, spindle, mixed, signet-ring, and balloon cell. Whereas all epithelioid, spindle, and mixed

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47

Sagre, Mauricio Bermúdez, Christian Ospina Pérez, Jennyfer Ortega Guatame, et al. "Soft Tissue Perivascular Epithelioid Cell Tumour: An Unusual Finding." Prague Medical Report 122, no. 2 (2021): 112–17. http://dx.doi.org/10.14712/23362936.2021.12.

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Perivascular epithelioid cell tumour (PEComa) is a rare mesenchymal tumour made up of clear perivascular cells with epithelioid characteristics, which co-expresses muscle and melanocytic markers with a component of spindle cells, like sarcoma and variety of other tissues. This time, we present the case of a young patient with a tumour in the dorsal region of progressive growth, compatible with PEComa of soft tissue after histopathological and immunohistochemical analysis.

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48

Bartos, V., and A. Farkasova. "Spindle Cell Melanoma Harboring a Nodule of Epitheloid Cell Melanoma Component: A Study of a Diagnostically Challenging Case." Acta Medica Martiniana 21, no. 1 (2021): 26–33. http://dx.doi.org/10.2478/acm-2021-0005.

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Abstract Background: Melanoma is a very heterogeneous human neoplasm. In addition to four major (conventional) histologic subtypes a number of uncommon variants do exist. Objective: An unusual case of a spindle cell melanoma (SCM) containing a demarcated nodule of conventional epitheliod cell melanoma component is described. Material and Methods: A 71-year-old man manifested with a protuberated ulcerated skin tumor arising on the right forearm. The resected biopsy was analyzed immunohistochemically with a variety of anti-human antibodies. Results: The tumor consisted of a highly cellular mass

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49

Lian, D. W. Q., K. L. Chuah, M. H. W. Cheng, and W. M. Yap. "Malignant perivascular epithelioid cell tumour of the fibula: a report and a short review of bone perivascular epithelioid cell tumour." Journal of Clinical Pathology 61, no. 10 (2008): 1127–29. http://dx.doi.org/10.1136/jcp.2008.060137.

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Perivascular epithelioid cell tumour (PEComa) is a term applied to a family of mesenchymal tumours composed of varying proportions of spindle and epithelioid cell components associated with HMB-45 expression. PEComa rarely arises in the soft tissue, visceral organs, skin and bone. This report details an instance when a purely epithelioid PEComa arose from the right fibula of a 52-year-old Chinese woman without features of tuberous sclerosis complex. The excision specimen disclosed an epithelioid tumour with a nested pattern associated with areas of nuclear pleomorphism, mitotic activity, necro

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50

Begum, Shainaz, Balina Lakshmi Nirmala, and Srikanth Shastry. "Hemangioendothelioma of the Forehead – A Rare Case Report." Saudi Journal of Pathology and Microbiology 8, no. 12 (2023): 300–303. http://dx.doi.org/10.36348/sjpm.2023.v08i12.004.

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Hemangioendothelioma is the term used to name those vascular neoplasms that show a borderline biological behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. Although originally spindle cell hemangioendothelioma was proposed as a specific clinicopathologic variant of hemangioendothelioma, currently, it is considered as an entirely benign lesion, and thus, the name spindle cell hemangioma seems to be the most accurate for this lesion. Authentic hemangioendotheliomas involving the skin and soft tissues include Papillary intralymphatic angioendothelioma (

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