Relevant bibliographies by topics / Epitranscriptoma

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
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Academic literature on the topic 'Epitranscriptoma'

Author: Grafiati
Published: 10 September 2021
Last updated: 29 July 2025

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Journal articles on the topic "Epitranscriptoma"

1

Schaefer, Matthias R. "The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics?" Genes 12, no. 3 (2021): 345. http://dx.doi.org/10.3390/genes12030345.

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RNA modifications, long considered to be molecular curiosities embellishing just abundant and non-coding RNAs, have now moved into the focus of both academic and applied research. Dedicated research efforts (epitranscriptomics) aim at deciphering the underlying principles by determining RNA modification landscapes and investigating the molecular mechanisms that establish, interpret and modulate the information potential of RNA beyond the combination of four canonical nucleotides. This has resulted in mapping various epitranscriptomes at high resolution and in cataloguing the effects caused by
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Hou, Quancan, and Xiangyuan Wan. "Epigenome and Epitranscriptome: Potential Resources for Crop Improvement." International Journal of Molecular Sciences 22, no. 23 (2021): 12912. http://dx.doi.org/10.3390/ijms222312912.

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Crop breeding faces the challenge of increasing food demand, especially under climatic changes. Conventional breeding has relied on genetic diversity by combining alleles to obtain desired traits. In recent years, research on epigenetics and epitranscriptomics has shown that epigenetic and epitranscriptomic diversity provides additional sources for crop breeding and harnessing epigenetic and epitranscriptomic regulation through biotechnologies has great potential for crop improvement. Here, we review epigenome and epitranscriptome variations during plant development and in response to environm
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Xia, Zhen, Min Tang, Jiayan Ma, et al. "Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase." Nucleic Acids Research 49, no. 13 (2021): 7361–74. http://dx.doi.org/10.1093/nar/gkab517.

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Abstract N6-methyladenosine (m6A) is a common modification on endogenous RNA transcripts in mammalian cells. Technologies to precisely modify the RNA m6A levels at specific transcriptomic loci empower interrogation of biological functions of epitranscriptomic modifications. Here, we developed a bidirectional dCasRx epitranscriptome editing platform composed of a nuclear-localized dCasRx conjugated with either a methyltransferase, METTL3, or a demethylase, ALKBH5, to manipulate methylation events at targeted m6A sites. Leveraging this platform, we specifically and efficiently edited m6A modific
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Tang, Yujiao, Kunqi Chen, Bowen Song, et al. "m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome." Nucleic Acids Research 49, no. D1 (2020): D134—D143. http://dx.doi.org/10.1093/nar/gkaa692.

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Abstract N 6-Methyladenosine (m6A) is the most prevalent RNA modification on mRNAs and lncRNAs. It plays a pivotal role during various biological processes and disease pathogenesis. We present here a comprehensive knowledgebase, m6A-Atlas, for unraveling the m6A epitranscriptome. Compared to existing databases, m6A-Atlas features a high-confidence collection of 442 162 reliable m6A sites identified from seven base-resolution technologies and the quantitative (rather than binary) epitranscriptome profiles estimated from 1363 high-throughput sequencing samples. It also offers novel features, suc
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Evke, Sara, Qishan Lin, Juan Andres Melendez, and Thomas John Begley. "Epitranscriptomic Reprogramming Is Required to Prevent Stress and Damage from Acetaminophen." Genes 13, no. 3 (2022): 421. http://dx.doi.org/10.3390/genes13030421.

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Epitranscriptomic marks, in the form of enzyme catalyzed RNA modifications, play important gene regulatory roles in response to environmental and physiological conditions. However, little is known with respect to how acute toxic doses of pharmaceuticals influence the epitranscriptome. Here we define how acetaminophen (APAP) induces epitranscriptomic reprogramming and how the writer Alkylation Repair Homolog 8 (Alkbh8) plays a key gene regulatory role in the response. Alkbh8 modifies tRNA selenocysteine (tRNASec) to translationally regulate the production of glutathione peroxidases (Gpx’s) and
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del Valle-Morales, Daniel, Patricia Le, Michela Saviana, et al. "The Epitranscriptome in miRNAs: Crosstalk, Detection, and Function in Cancer." Genes 13, no. 7 (2022): 1289. http://dx.doi.org/10.3390/genes13071289.

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The epitranscriptome encompasses all post-transcriptional modifications that occur on RNAs. These modifications can alter the function and regulation of their RNA targets, which, if dysregulated, result in various diseases and cancers. As with other RNAs, miRNAs are highly modified by epitranscriptomic modifications such as m6A methylation, 2′-O-methylation, m5C methylation, m7G methylation, polyuridine, and A-to-I editing. miRNAs are a class of small non-coding RNAs that regulates gene expression at the post-transcriptional level. miRNAs have gathered high clinical interest due to their role
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Imbriano, Carol, Viviana Moresi, Silvia Belluti, et al. "Epitranscriptomics as a New Layer of Regulation of Gene Expression in Skeletal Muscle: Known Functions and Future Perspectives." International Journal of Molecular Sciences 24, no. 20 (2023): 15161. http://dx.doi.org/10.3390/ijms242015161.

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Epitranscriptomics refers to post-transcriptional regulation of gene expression via RNA modifications and editing that affect RNA functions. Many kinds of modifications of mRNA have been described, among which are N6-methyladenosine (m6A), N1-methyladenosine (m1A), 7-methylguanosine (m7G), pseudouridine (Ψ), and 5-methylcytidine (m5C). They alter mRNA structure and consequently stability, localization and translation efficiency. Perturbation of the epitranscriptome is associated with human diseases, thus opening the opportunity for potential manipulations as a therapeutic approach. In this rev
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Ofusa, Ken, Ryota Chijimatsu, and Hideshi Ishii. "Detection techniques for epitranscriptomic marks." American Journal of Physiology-Cell Physiology 322, no. 4 (2022): C787—C793. http://dx.doi.org/10.1152/ajpcell.00460.2021.

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Similar to epigenetic DNA modification, RNA can be methylated and altered for stability and processing. RNA modifications, namely, epitranscriptomes, involve the following three functions: writing, erasing, and reading of marks. Methods for measurement and position detection are useful for the assessment of cellular function and human disease biomarkers. After pyrimidine 5-methylcytosine was reported for the first time a hundred years ago, numerous techniques have been developed for studying nucleotide modifications, including RNAs. Recent studies have focused on high-throughput and direct mea
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Yang, Chengfeng, and Zhishan Wang. "The Epitranscriptomic Mechanism of Metal Toxicity and Carcinogenesis." International Journal of Molecular Sciences 23, no. 19 (2022): 11830. http://dx.doi.org/10.3390/ijms231911830.

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Metals are common toxic environmental pollutants. Acute or chronic exposure to metal pollutants causes severe adverse health effects in animals and humans, such as developmental retardation, abnormal metabolism, and disorders of cardiovascular, neurologic, respiratory, reproductive, and urologic systems. Moreover, several metals (arsenic, cadmium, chromium, and nickel) are classified as potent Group I carcinogens and cause various types of cancer in humans. Although the toxicity and carcinogenicity of metal pollutants are well recognized, the underlying mechanisms have not been clearly defined
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Wanowska, Elzbieta, Alexis McFeely, and Joanna Sztuba-Solinska. "The Role of Epitranscriptomic Modifications in the Regulation of RNA–Protein Interactions." BioChem 2, no. 4 (2022): 241–59. http://dx.doi.org/10.3390/biochem2040017.

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Epitranscriptome refers to post-transcriptional modifications to RNA and their associated regulatory factors that can govern changes in an organism’s cells in response to various environmental stimuli. Recent studies have recognized over 170 distinct chemical signatures in RNA, and the list keeps expanding. These modifications are hypothesized to have roles beyond simply fine-tuning the structure and function of RNA, as studies have linked them to various infectious and noninfectious diseases in humans. Dedicated cellular machinery comprising of RNA-binding proteins (RBPs) that can write, eras
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Dissertations / Theses on the topic "Epitranscriptoma"

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Relier, Sébastien. "The epitranscriptome dynamic in colorectal cancer." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT063.

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Le cancer colorectal demeure un problème de santé majeur avec près de deux millions de nouveaux cas en 2019 à travers le monde. Le cancer colorectal est associé à un fort taux de récidive et son taux de mortalité est important après le développement métastatique. Ces propriétés de résistance et de dissémination dans l’organisme sont restreintes à une sous-population de cellules tumorales appelées Cellules Souches Cancéreuses (CSC). Bien qu’elles constituent une cible idéale pour le traitement du cancer colorectal, il demeure difficile de les cibler. En effet, ces cellules sont capables de s’ad
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Bertero, Alessandro. "Activin/nodal signalling controls the epigenome and epitranscriptome of human pluripotent stem cells." Thesis, University of Cambridge, 2016. https://www.repository.cam.ac.uk/handle/1810/274120.

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Human pluripotent stem cells (hPSCs) are an invaluable model for cellular and developmental biology, and hold great potential for translational applications. While great progress has been made in elucidating the signalling pathways regulating pluripotency and differentiation, our mechanistic understanding of the downstream regulations is still incomplete. Moreover, studies aimed at clarifying these aspects are severely impeded by the lack of efficient methods to conditionally modulate gene expression in hPSCs and hPSC-derived cells. In this dissertation I provide new insights into the molecula
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Lesbirel, Simon. "Dissecting the interplay between TREX and the N6-methyladenosine epitranscriptomic machinery." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19184/.

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Montuori, Giulia. "The m6A RNA modification sustains neuroblastoma tumour aggressiveness." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/276989.

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The N6-methyladenosine, also known as m6A, is the most common post-transcriptional modification in mRNAs and long non-coding RNAs and that profoundly influences mRNA biology, from early processing in the nucleus to final steps of translation and decay in the cytoplasm. Taking into consideration the importance of RNA in shaping cell fate, m6A is widely recognized as an additional layer in the regulation of gene expression, also thanks to its dynamic and reversible nature. Therefore, it is not surprising that any misregulation in m6A content might lead to the loss of cellular homeostasis. This e
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Montuori, Giulia. "The m6A RNA modification sustains neuroblastoma tumour aggressiveness." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/276989.

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The N6-methyladenosine, also known as m6A, is the most common post-transcriptional modification in mRNAs and long non-coding RNAs and that profoundly influences mRNA biology, from early processing in the nucleus to final steps of translation and decay in the cytoplasm. Taking into consideration the importance of RNA in shaping cell fate, m6A is widely recognized as an additional layer in the regulation of gene expression, also thanks to its dynamic and reversible nature. Therefore, it is not surprising that any misregulation in m6A content might lead to the loss of cellular homeostasis. This e
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GRECO, FEDERICA. "THE ROLE OF THE M6A METHYLTRANSFERASE METTL3 IN AN IN VITRO MODEL OF ANTIGEN-SELECTED GERMINAL CENTER B CELLS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/824035.

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N6-methyladenosine (m6A) represents the most abundant modification introduced into messenger RNA. In mammals, m6A regulates gene expression by controlling different facets of mRNA metabolism including splicing, translation and stability. Emerging evidences have assigned to m6A a critical role in the regulation of cellular and humoral immunity. To date, the function of m6A in mature B cells, especially those recruited into T-cell dependent immune responses, remains unexplored. Here, we show that the Mettl3 gene, encoding for the catalytic subunit of the m6A methyltransferase complex, is expre
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Bornaque, Florine. "Rôle de l'épitranscriptome dans la physiopathologie de la cellule β pancréatique". Thesis, Université de Lille (2018-2021), 2021. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2021/2021LILUS059.pdf.

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La prévalence du diabète dans le monde ne cesse d’augmenter, avec une estimation de 700 millions de malades en 2045. La compréhension des mécanismes impliqués dans le développement de la maladie est devenue un enjeu majeur de santé publique pour limiter la progression du diabète dans le monde.Le diabète de type 2 (DT2) se caractérise par une hyperglycémie chronique causée par une résistance à l’insuline des tissus périphériques et une perte de fonction et/ou de masse des cellules β pancréatiques. Ces cellules, présentes dans les îlots de Langerhans, interviennent dans la régulation de l’homéos
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Hebras, Jade. "Caractérisation moléculaire du petit ARN nucléolaire SNORD115 : un rôle dans la régulation de l'expression et de la fonction du récepteur à la sérotonine 5-HT2C ?" Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30209.

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Le nucléole des mammifères contient des centaines de petits ARN nucléolaires à boîte C/D (SNORD) dont la grande majorité guide une 2'-O-ribose méthylation sur les précurseurs des ARN ribosomiques (pré-ARNr). Certains SNORD facilitent aussi les clivages que subissent le pré-ARNr ou modifient le petit ARN nucléaire U6. Des travaux récents laissent également entrevoir que certains SNORD interagissent avec des ARNm. C'est le cas par exemple pour SNORD115 qui est au cœur de mon travail de thèse. SNORD115 est exprimé uniquement dans le cerveau à partir de nombreux gènes répétés en tandem situés au l
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Nina, João Miguel Barbosa. "Understanding the role of parasites' epitranscriptome." Master's thesis, 2016. http://hdl.handle.net/10451/25698.

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Tese de mestrado em Biologia Molecular e Genética, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2016<br>Trypanosoma brucei (T. brucei) é um parasita unicelular que causa a doença do sono. Durante o seu ciclo de vida, T. brucei alterna entre dois hospedeiros: um mamífero e a mosca tsetse. Para sobreviver às diferentes condições ambientais encontradas no interior de cada um dos dois hospedeiros, o parasita passa por processos de diferenciação; os estágios do ciclo de vida do parasita diferem entre si morfologicamente e fisiologicamente, consequência de uma expressão gé
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Viegas, Idálio de Jesus Contreiras. "N6-methyladenosine, a new modification in T. brucei epitranscriptome." Master's thesis, 2014. http://hdl.handle.net/10362/13968.

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Trypanosoma bruceiis a unicellulareukaryote parasite that causes human sleeping sickness. In this parasite, transcription is mainly constitutive and gene expression regulation occurs essentially at post-transcriptional level. N6-methyladenosine (m6A) is an RNA modification associated withpost-transcriptional gene regulation in eukaryotes. These observations led to the proposalthat this modification occurs in T. bruceitranscriptome and is involved in post-transcriptional gene regulation. In this thesis, m6A was detected for the first time in T. bruceiRNA and add
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Books on the topic "Epitranscriptoma"

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Chirathivat, Napon. Zc3h13: A Master Regulator of Epitranscriptomic Landscape during Early Development. [publisher not identified], 2021.

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Kim, Yoon Anna. Epitranscriptomic Alterations in Alzheimer’s Disease: The Role of MicroRNA Methylation in the Regulation of Tau Proteostasis. [publisher not identified], 2021.

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Book chapters on the topic "Epitranscriptoma"

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Wang, Hongzhou, Frank Morales Shnaider, Elizabeth Martin, and Norman H. L. Chiu. "Epitranscriptomic Mass Spectrometry." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3918-4_21.

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Litholdo, Celso Gaspar, and Cécile Bousquet-Antonelli. "Chemical RNA Modifications: The Plant Epitranscriptome." In Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14760-0_11.

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Roy, Bijoyita. "Effects of mRNA Modifications on Translation: An Overview." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1374-0_20.

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AbstractThe mRNA epitranscriptome imparts diversity to gene expression by installing chemical modifications. Advances in detection methods have identified chemical modifications in eukaryotic, bacterial, and viral messenger RNAs (mRNAs). The biological functions of modifications in mRNAs still remain to be understood. Chemical modifications are introduced in synthetic mRNAs meant for therapeutic applications to maximize expression from the synthetic mRNAs and to evade the host immune response. This overview provides a background of chemical modifications found in mRNAs, with an emphasis on pse
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Sharma, Shikha, and Nibedita Lenka. "Epitranscriptomic Signatures in Neural Development and Disease." In Epitranscriptomics. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71612-7_3.

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Van Horn, Megan L., and Anna M. Kietrys. "Epitranscriptomic Modifications and How to Find Them." In Epitranscriptomics. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71612-7_6.

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Zhang, Xiao-Qin, and Jian-Hua Yang. "Decoding the Atlas of RNA Modifications from Epitranscriptome Sequencing Data." In Epitranscriptomics. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8808-2_8.

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Wu, Junzhou, Thomas J. Begley, and Peter C. Dedon. "Tools for Understanding the Chemical Biology of the tRNA Epitranscriptome." In Handbook of Chemical Biology of Nucleic Acids. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9776-1_42.

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Wu, Junzhou, Thomas J. Begley, and Peter C. Dedon. "Tools for Understanding the Chemical Biology of the tRNA Epitranscriptome." In Handbook of Chemical Biology of Nucleic Acids. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-16-1313-5_42-1.

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George, Harry, Jernej Ule, and Shobbir Hussain. "Illustrating the Epitranscriptome at Nucleotide Resolution Using Methylation-iCLIP (miCLIP)." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6807-7_7.

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Xu, Qingru, Kunqi Chen, and Jia Meng. "WHISTLE: A Functionally Annotated High-Accuracy Map of Human m6A Epitranscriptome." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1307-8_28.

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Conference papers on the topic "Epitranscriptoma"

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Chou, Ping-Chieh, Liang Liu, Elizabeth Forbes, Ashley Ballard, Tao Li, and Wei Zhang. "Abstract B98: IGFBP2 reprograms pancreatic cancer immune surveillance at epitranscriptome levels." In Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; November 17-20, 2019; Boston, MA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/2326-6074.tumimm19-b98.

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Evmenov, K. S., V. V. Volodin, N. I. Ponomareva, et al. "THE ROLE OF M6A RNA MODIFICATIONS IN THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-234.

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Epitranscriptomic analysis of M6A-methylation profiles in biopsies of patients with chronic hepatitis B and D showed the presence of differentially methylated M6A sites in RNA in patients at different stages of liver disease. Using targeted m6A RNA methylation, an in vitro study demonstrated the involvement of individual sites in increasing cell malignancy in two models of human hepatoma cells.
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Reports on the topic "Epitranscriptoma"

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Burns, Malcom, and Gavin Nixon. Literature review on analytical methods for the detection of precision bred products. Food Standards Agency, 2023. http://dx.doi.org/10.46756/sci.fsa.ney927.

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The Genetic Technology (Precision Breeding) Act (England) aims to develop a science-based process for the regulation and authorisation of precision bred organisms (PBOs). PBOs are created by genetic technologies but exhibit changes which could have occurred through traditional processes. This current review, commissioned by the Food Standards Agency (FSA), aims to clarify existing terminologies, explore viable methods for the detection, identification, and quantification of products of precision breeding techniques, address and identify potential solutions to the analytical challenges presente
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