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Journal articles on the topic 'Epitranscriptoma'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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1

Schaefer, Matthias R. "The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics?" Genes 12, no. 3 (2021): 345. http://dx.doi.org/10.3390/genes12030345.

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RNA modifications, long considered to be molecular curiosities embellishing just abundant and non-coding RNAs, have now moved into the focus of both academic and applied research. Dedicated research efforts (epitranscriptomics) aim at deciphering the underlying principles by determining RNA modification landscapes and investigating the molecular mechanisms that establish, interpret and modulate the information potential of RNA beyond the combination of four canonical nucleotides. This has resulted in mapping various epitranscriptomes at high resolution and in cataloguing the effects caused by

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Hou, Quancan, and Xiangyuan Wan. "Epigenome and Epitranscriptome: Potential Resources for Crop Improvement." International Journal of Molecular Sciences 22, no. 23 (2021): 12912. http://dx.doi.org/10.3390/ijms222312912.

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Crop breeding faces the challenge of increasing food demand, especially under climatic changes. Conventional breeding has relied on genetic diversity by combining alleles to obtain desired traits. In recent years, research on epigenetics and epitranscriptomics has shown that epigenetic and epitranscriptomic diversity provides additional sources for crop breeding and harnessing epigenetic and epitranscriptomic regulation through biotechnologies has great potential for crop improvement. Here, we review epigenome and epitranscriptome variations during plant development and in response to environm

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Xia, Zhen, Min Tang, Jiayan Ma, et al. "Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase." Nucleic Acids Research 49, no. 13 (2021): 7361–74. http://dx.doi.org/10.1093/nar/gkab517.

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Abstract N6-methyladenosine (m6A) is a common modification on endogenous RNA transcripts in mammalian cells. Technologies to precisely modify the RNA m6A levels at specific transcriptomic loci empower interrogation of biological functions of epitranscriptomic modifications. Here, we developed a bidirectional dCasRx epitranscriptome editing platform composed of a nuclear-localized dCasRx conjugated with either a methyltransferase, METTL3, or a demethylase, ALKBH5, to manipulate methylation events at targeted m6A sites. Leveraging this platform, we specifically and efficiently edited m6A modific

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Tang, Yujiao, Kunqi Chen, Bowen Song, et al. "m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome." Nucleic Acids Research 49, no. D1 (2020): D134—D143. http://dx.doi.org/10.1093/nar/gkaa692.

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Abstract N 6-Methyladenosine (m6A) is the most prevalent RNA modification on mRNAs and lncRNAs. It plays a pivotal role during various biological processes and disease pathogenesis. We present here a comprehensive knowledgebase, m6A-Atlas, for unraveling the m6A epitranscriptome. Compared to existing databases, m6A-Atlas features a high-confidence collection of 442 162 reliable m6A sites identified from seven base-resolution technologies and the quantitative (rather than binary) epitranscriptome profiles estimated from 1363 high-throughput sequencing samples. It also offers novel features, suc

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Evke, Sara, Qishan Lin, Juan Andres Melendez, and Thomas John Begley. "Epitranscriptomic Reprogramming Is Required to Prevent Stress and Damage from Acetaminophen." Genes 13, no. 3 (2022): 421. http://dx.doi.org/10.3390/genes13030421.

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Epitranscriptomic marks, in the form of enzyme catalyzed RNA modifications, play important gene regulatory roles in response to environmental and physiological conditions. However, little is known with respect to how acute toxic doses of pharmaceuticals influence the epitranscriptome. Here we define how acetaminophen (APAP) induces epitranscriptomic reprogramming and how the writer Alkylation Repair Homolog 8 (Alkbh8) plays a key gene regulatory role in the response. Alkbh8 modifies tRNA selenocysteine (tRNASec) to translationally regulate the production of glutathione peroxidases (Gpx’s) and

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del Valle-Morales, Daniel, Patricia Le, Michela Saviana, et al. "The Epitranscriptome in miRNAs: Crosstalk, Detection, and Function in Cancer." Genes 13, no. 7 (2022): 1289. http://dx.doi.org/10.3390/genes13071289.

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The epitranscriptome encompasses all post-transcriptional modifications that occur on RNAs. These modifications can alter the function and regulation of their RNA targets, which, if dysregulated, result in various diseases and cancers. As with other RNAs, miRNAs are highly modified by epitranscriptomic modifications such as m6A methylation, 2′-O-methylation, m5C methylation, m7G methylation, polyuridine, and A-to-I editing. miRNAs are a class of small non-coding RNAs that regulates gene expression at the post-transcriptional level. miRNAs have gathered high clinical interest due to their role

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Imbriano, Carol, Viviana Moresi, Silvia Belluti, et al. "Epitranscriptomics as a New Layer of Regulation of Gene Expression in Skeletal Muscle: Known Functions and Future Perspectives." International Journal of Molecular Sciences 24, no. 20 (2023): 15161. http://dx.doi.org/10.3390/ijms242015161.

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Epitranscriptomics refers to post-transcriptional regulation of gene expression via RNA modifications and editing that affect RNA functions. Many kinds of modifications of mRNA have been described, among which are N6-methyladenosine (m6A), N1-methyladenosine (m1A), 7-methylguanosine (m7G), pseudouridine (Ψ), and 5-methylcytidine (m5C). They alter mRNA structure and consequently stability, localization and translation efficiency. Perturbation of the epitranscriptome is associated with human diseases, thus opening the opportunity for potential manipulations as a therapeutic approach. In this rev

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Ofusa, Ken, Ryota Chijimatsu, and Hideshi Ishii. "Detection techniques for epitranscriptomic marks." American Journal of Physiology-Cell Physiology 322, no. 4 (2022): C787—C793. http://dx.doi.org/10.1152/ajpcell.00460.2021.

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Similar to epigenetic DNA modification, RNA can be methylated and altered for stability and processing. RNA modifications, namely, epitranscriptomes, involve the following three functions: writing, erasing, and reading of marks. Methods for measurement and position detection are useful for the assessment of cellular function and human disease biomarkers. After pyrimidine 5-methylcytosine was reported for the first time a hundred years ago, numerous techniques have been developed for studying nucleotide modifications, including RNAs. Recent studies have focused on high-throughput and direct mea

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9

Yang, Chengfeng, and Zhishan Wang. "The Epitranscriptomic Mechanism of Metal Toxicity and Carcinogenesis." International Journal of Molecular Sciences 23, no. 19 (2022): 11830. http://dx.doi.org/10.3390/ijms231911830.

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Metals are common toxic environmental pollutants. Acute or chronic exposure to metal pollutants causes severe adverse health effects in animals and humans, such as developmental retardation, abnormal metabolism, and disorders of cardiovascular, neurologic, respiratory, reproductive, and urologic systems. Moreover, several metals (arsenic, cadmium, chromium, and nickel) are classified as potent Group I carcinogens and cause various types of cancer in humans. Although the toxicity and carcinogenicity of metal pollutants are well recognized, the underlying mechanisms have not been clearly defined

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10

Wanowska, Elzbieta, Alexis McFeely, and Joanna Sztuba-Solinska. "The Role of Epitranscriptomic Modifications in the Regulation of RNA–Protein Interactions." BioChem 2, no. 4 (2022): 241–59. http://dx.doi.org/10.3390/biochem2040017.

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Epitranscriptome refers to post-transcriptional modifications to RNA and their associated regulatory factors that can govern changes in an organism’s cells in response to various environmental stimuli. Recent studies have recognized over 170 distinct chemical signatures in RNA, and the list keeps expanding. These modifications are hypothesized to have roles beyond simply fine-tuning the structure and function of RNA, as studies have linked them to various infectious and noninfectious diseases in humans. Dedicated cellular machinery comprising of RNA-binding proteins (RBPs) that can write, eras

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11

Ma, Jiongming, Bowen Song, Zhen Wei, et al. "m5C-Atlas: a comprehensive database for decoding and annotating the 5-methylcytosine (m5C) epitranscriptome." Nucleic Acids Research 50, no. D1 (2021): D196—D203. http://dx.doi.org/10.1093/nar/gkab1075.

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Abstract 5-Methylcytosine (m5C) is one of the most prevalent covalent modifications on RNA. It is known to regulate a broad variety of RNA functions, including nuclear export, RNA stability and translation. Here, we present m5C-Atlas, a database for comprehensive collection and annotation of RNA 5-methylcytosine. The database contains 166 540 m5C sites in 13 species identified from 5 base-resolution epitranscriptome profiling technologies. Moreover, condition-specific methylation levels are quantified from 351 RNA bisulfite sequencing samples gathered from 22 different studies via an integrati

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Shoaib, Yasira, Babar Usman, Hunseung Kang, and Ki-Hong Jung. "Epitranscriptomics: An Additional Regulatory Layer in Plants’ Development and Stress Response." Plants 11, no. 8 (2022): 1033. http://dx.doi.org/10.3390/plants11081033.

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Epitranscriptomics has added a new layer of regulatory machinery to eukaryotes, and the advancement of sequencing technology has revealed more than 170 post-transcriptional modifications in various types of RNAs, including messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), and long non-coding RNA (lncRNA). Among these, N6-methyladenosine (m6A) and N5-methylcytidine (m5C) are the most prevalent internal mRNA modifications. These regulate various aspects of RNA metabolism, mainly mRNA degradation and translation. Recent advances have shown that regulation of RNA fate mediated by th

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Cleynen, Alice, Agin Ravindran, Dipti Talaulikar, Eduardo Eyras, and Nikolay Shirokikh. "Defining Therapeutic Epitranscriptome of Multiple Myeloma for Accurate Subtyping and Personalized Prognostics." Blood 144, Supplement 1 (2024): 4652. https://doi.org/10.1182/blood-2024-204896.

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Background: Multiple Myeloma (MM) is a heterogeneous disease, with risk classification (standard risk SR and high risk HR) mostly defined by cytogenetic changes. RNA covalent modifications (collectively addressed as the epitranscriptome) have recently emerged as key signatures of cancer progression, with RNA modification writer and eraser inhibitors being clinically trialed. For example, inhibitor of FTO, an eraser for N6-methyladenosine (m6A), was shown to synergistically suppress MM for mouse models in combined treatment. However, we still lack accurate, nucleotide-resolved landscape of the

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Sikorski, Vilbert, Pasi Karjalainen, Daria Blokhina, et al. "Epitranscriptomics of Ischemic Heart Disease—The IHD-EPITRAN Study Design and Objectives." International Journal of Molecular Sciences 22, no. 12 (2021): 6630. http://dx.doi.org/10.3390/ijms22126630.

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Epitranscriptomic modifications in RNA can dramatically alter the way our genetic code is deciphered. Cells utilize these modifications not only to maintain physiological processes, but also to respond to extracellular cues and various stressors. Most often, adenosine residues in RNA are targeted, and result in modifications including methylation and deamination. Such modified residues as N-6-methyl-adenosine (m6A) and inosine, respectively, have been associated with cardiovascular diseases, and contribute to disease pathologies. The Ischemic Heart Disease Epitranscriptomics and Biomarkers (IH

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Esteller Badosa, Manel. "Epigenetic and Epitranscriptomic Pharmacological Compound." Anales de la Real Academia Nacional de Farmacia, no. 90(01) (March 31, 2024): 7–19. http://dx.doi.org/10.53519/analesranf.2024.90.01.01.

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The activity of our cells not only depends on the naked DNA sequence but also on the chemical marks that control the genetic material. The most recognized regulatory level in this field is epigenetics. This includes DNA methylation and post-translational modifications of histones that confer specificity to gene expression and determine the three-dimensional conformation of our genome. A second component would be RNA modifications, a field known as epitranscriptomics. Chemical changes in both coding and messenger RNAs determine the activity of these molecules. Both the epigenome and epitranscri

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16

García‑Vílchez, Raquel, Ana M. Añazco‑Guenkova, Sabine Dietmann, et al. "METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer." Molecular Cancer 22, no. 1 (2023): 119. https://doi.org/10.1186/s12943-023-01809-8.

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Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show that the transfer RNA N7-methylguanosine (m7G) transferase METTL1 is highly expressed in primary and advanced prostate tumours. Mechanistically, we find that <i>METTL1</i> depletion causes the loss of m7G tRNA methylation and promotes the biogenesis of a novel class of small non-coding RNAs derived from 5'tRNA fragments. 5'tRNA-derived small RNA

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17

Kvolik Pavić, Ana, Josipa Čonkaš, Ivan Mumlek, Vedran Zubčić, and Petar Ozretić. "Clinician’s Guide to Epitranscriptomics: An Example of N1-Methyladenosine (m1A) RNA Modification and Cancer." Life 14, no. 10 (2024): 1230. http://dx.doi.org/10.3390/life14101230.

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Epitranscriptomics is the study of modifications of RNA molecules by small molecular residues, such as the methyl (-CH3) group. These modifications are inheritable and reversible. A specific group of enzymes called “writers” introduces the change to the RNA; “erasers” delete it, while “readers” stimulate a downstream effect. Epitranscriptomic changes are present in every type of organism from single-celled ones to plants and animals and are a key to normal development as well as pathologic processes. Oncology is a fast-paced field, where a better understanding of tumor biology and (epi)genetic

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18

Morales Shnaider, Frank A., Coston Eddings, Jennifer Simpson, Bakhos A. Tannous, and Norman Chiu. "Abstract B038: Accurate quantitative profiling of rna modifications and their associations with glioblastoma." Cancer Research 84, no. 5_Supplement_1 (2024): B038. http://dx.doi.org/10.1158/1538-7445.brain23-b038.

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Abstract Every chemical group that is added to one of the canonical ribonucleotides, i.e., RNA modification, in a specific transcript can potentially alter the RNA folding as well as the RNA-protein interactions. Hence, RNA modifications are considered as post-transcriptional regulators for RNA splicing, RNA stability, and translation, just to name a few. Today, 170+ different RNA modifications have been identified, but only half a dozen of them are linked to glioblastoma (GBM). On the other hand, other RNA biology studies indicated the interplays between RNA modifications within a specific ep

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Dr., HumnaAyyaz Butt, Javaria Syed Dr., Asma Sajid Dr., and Hamid Jugg Dr. "EXAMINE THE MASS SPECTROMETRY METHOD FOR TESTING THE EPITRANSCRIPTOME IN CELLULAR LYSATES." Journal For Innovative Development in Pharmaceutical and Technical Science 2, no. 11 (2019): 110–19. https://doi.org/10.5281/zenodo.4433679.

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New findings in the field of epitranscriptomics have led to resurgence in the study of modified nucleic acids in RNA. Current mass spectrometry methods for the study of the epitranscriptome lack key information on the state of modified nucleotides in RNA and cellular lysates. Presented here is the first report of modified nucleotides in RNA and the cell, and provides the first reported method for the untargeted analysis of these compounds using HILIC-HRMS. We utilized a novel extraction method to measure both the bound and unbound modified nucleotides in a single sample. This method also provi

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20

Chen, Kunqi, Zhen Wei, Hui Liu, et al. "Enhancing Epitranscriptome Module Detection from m6A-Seq Data Using Threshold-Based Measurement Weighting Strategy." BioMed Research International 2018 (June 14, 2018): 1–15. http://dx.doi.org/10.1155/2018/2075173.

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To date, with well over 100 different types of RNA modifications associated with various molecular functions identified on diverse types of RNA molecules, the epitranscriptome has emerged to be an important layer for gene expression regulation. It is of crucial importance and increasing interest to understand how the epitranscriptome is regulated to facilitate different biological functions from a global perspective, which may be carried forward by finding biologically meaningful epitranscriptome modules that respond to upstream epitranscriptome regulators and lead to downstream biological fun

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21

Moshitch-Moshkovitz, Sharon, Dan Dominissini, and Gideon Rechavi. "The epitranscriptome toolbox." Cell 185, no. 5 (2022): 764–76. http://dx.doi.org/10.1016/j.cell.2022.02.007.

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22

Schwartz, Schraga. "Cracking the epitranscriptome." RNA 22, no. 2 (2016): 169–74. http://dx.doi.org/10.1261/rna.054502.115.

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23

Fray, Rupert G., and Gordon G. Simpson. "The Arabidopsis epitranscriptome." Current Opinion in Plant Biology 27 (October 2015): 17–21. http://dx.doi.org/10.1016/j.pbi.2015.05.015.

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24

Hoernes, Thomas Philipp, and Matthias David Erlacher. "Translating the epitranscriptome." Wiley Interdisciplinary Reviews: RNA 8, no. 1 (2016): e1375. http://dx.doi.org/10.1002/wrna.1375.

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Morales, David Rodríguez, Sarah Rennie, and Shizuka Uchida. "Benchmarking RNA Editing Detection Tools." BioTech 12, no. 3 (2023): 56. http://dx.doi.org/10.3390/biotech12030056.

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RNA, like DNA and proteins, can undergo modifications. To date, over 170 RNA modifications have been identified, leading to the emergence of a new research area known as epitranscriptomics. RNA editing is the most frequent RNA modification in mammalian transcriptomes, and two types have been identified: (1) the most frequent, adenosine to inosine (A-to-I); and (2) the less frequent, cysteine to uracil (C-to-U) RNA editing. Unlike other epitranscriptomic marks, RNA editing can be readily detected from RNA sequencing (RNA-seq) data without any chemical conversions of RNA before sequencing librar

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Sharma, Bishwas, Ganesan Govindan, Yongfang Li, Ramanjulu Sunkar, and Brian D. Gregory. "RNA N6-Methyladenosine Affects Copper-Induced Oxidative Stress Response in Arabidopsis thaliana." Non-Coding RNA 10, no. 1 (2024): 8. http://dx.doi.org/10.3390/ncrna10010008.

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Recently, post-transcriptional regulation of mRNA mediated by N6-methyladenosine (m6A) has been found to have profound effects on transcriptome regulation during plant responses to various abiotic stresses. However, whether this RNA modification can affect an oxidative stress response in plants has not been studied. To assess the role of m6A modifications during copper-induced oxidative stress responses, m6A-IP-seq was performed in Arabidopsis seedlings exposed to high levels of copper sulfate. This analysis revealed large-scale shifts in this modification on the transcripts most relevant for

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Dominissini, Dan. "Roadmap to the epitranscriptome." Science 346, no. 6214 (2014): 1192.1–1192. http://dx.doi.org/10.1126/science.aaa1807.

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28

Rebelo-Guiomar, Pedro, Christopher A. Powell, Lindsey Van Haute, and Michal Minczuk. "The mammalian mitochondrial epitranscriptome." Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1862, no. 3 (2019): 429–46. http://dx.doi.org/10.1016/j.bbagrm.2018.11.005.

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29

du Toit, Andrea. "Expanding the mRNA epitranscriptome." Nature Reviews Molecular Cell Biology 17, no. 4 (2016): 201. http://dx.doi.org/10.1038/nrm.2016.35.

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Novoa, Eva Maria, Christopher E. Mason, and John S. Mattick. "Charting the unknown epitranscriptome." Nature Reviews Molecular Cell Biology 18, no. 6 (2017): 339–40. http://dx.doi.org/10.1038/nrm.2017.49.

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31

Bornaque, Florine, Clément Philippe Delannoy, Emilie Courty, et al. "Glucose Regulates m6A Methylation of RNA in Pancreatic Islets." Cells 11, no. 2 (2022): 291. http://dx.doi.org/10.3390/cells11020291.

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Type 2 diabetes is characterized by chronic hyperglycemia associated with impaired insulin action and secretion. Although the heritability of type 2 diabetes is high, the environment, including blood components, could play a major role in the development of the disease. Amongst environmental effects, epitranscriptomic modifications have been recently shown to affect gene expression and glucose homeostasis. The epitranscriptome is characterized by reversible chemical changes in RNA, with one of the most prevalent being the m6A methylation of RNA. Since pancreatic β cells fine tune glucose level

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Yang, Qiwei, Somayeh Vafaei, Ali Falahati, et al. "Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells." International Journal of Molecular Sciences 25, no. 2 (2024): 905. http://dx.doi.org/10.3390/ijms25020905.

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Bromodomain-containing proteins (BRDs) are involved in many biological processes, most notably epigenetic regulation of transcription, and BRD dysfunction has been linked to many diseases, including tumorigenesis. However, the role of BRDs in the pathogenesis of uterine fibroids (UFs) is entirely unknown. The present study aimed to determine the expression pattern of BRD9 in UFs and matched myometrium and further assess the impact of a BRD9 inhibitor on UF phenotype and epigenetic/epitranscriptomic changes. Our studies demonstrated that the levels of BRD9 were significantly upregulated in UFs

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Roy, Arunava, and Anandita Ghosh. "Epigenetic Restriction Factors (eRFs) in Virus Infection." Viruses 16, no. 2 (2024): 183. http://dx.doi.org/10.3390/v16020183.

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The ongoing arms race between viruses and their hosts is constantly evolving. One of the ways in which cells defend themselves against invading viruses is by using restriction factors (RFs), which are cell-intrinsic antiviral mechanisms that block viral replication and transcription. Recent research has identified a specific group of RFs that belong to the cellular epigenetic machinery and are able to restrict the gene expression of certain viruses. These RFs can be referred to as epigenetic restriction factors or eRFs. In this review, eRFs have been classified into two categories. The first c

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Rigopoulos, Christos Panagiotis, Marios Gkoris, Ilias Georgakopoulos-Soares, Ioannis Boulalas, and Apostolos Zaravinos. "Epitranscriptomics Regulation of CD70, CD80, and TIGIT in Cancer Immunity." International Journal of Molecular Sciences 26, no. 12 (2025): 5772. https://doi.org/10.3390/ijms26125772.

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Tumor development is mainly marked by the gradual transformation of cells that acquire capacities such as sustained growth signaling, evasion of growth suppression, resistance to cell death, and induction of angiogenesis, achieving replicative immortality and activating invasion and metastasis. How different epigenetic alterations like m1A, m5C, and m6A contribute to tumor development is a field that still needs to be investigated. The immune modulators, CD70, CD80, and TIGIT, mainly regulate T-cell activation and consequently the immune evasion of tumors. Here, we explored the presence and th

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Kundu, Anirban, Garrett J. Brinkley, Hyeyoung Nam, et al. "Abstract 3705: L-2HG, oncometabolite-driven epigenetic and epitranscriptomic reprogramming creates metabolic vulnerability in renal cancer." Cancer Research 83, no. 7_Supplement (2023): 3705. http://dx.doi.org/10.1158/1538-7445.am2023-3705.

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Abstract The oncometabolite, L-2-hydroxyglutarate (L-2HG) is elevated in the most common form of renal cell carcinoma-RCC (clear cell histology) and promotes tumor progression. L-2HG is structurally similar to α-ketoglutarate (α-KG). Therefore, L-2HG can competitively inhibit enzymes that utilize α-KG as a cofactor including α-KG-dependent dioxygenases that can profoundly impact gene expression via effects on the epigenome and epitranscriptome. RCC cell lines lack the L-2HG dehydrogenase enzyme (L2HGDH), resulting in their high L-2HG level. RNA-seq of control (high L-2GH) and an L2HGDH reconst

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Shen, Lisha, and Hao Yu. "Epitranscriptome engineering in crop improvement." Molecular Plant 14, no. 9 (2021): 1418–20. http://dx.doi.org/10.1016/j.molp.2021.08.006.

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O’Connell, Mary A., Niamh M. Mannion, and Liam P. Keegan. "The Epitranscriptome and Innate Immunity." PLOS Genetics 11, no. 12 (2015): e1005687. http://dx.doi.org/10.1371/journal.pgen.1005687.

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Krüttner, Sebastian, and Pico Caroni. "m6A-epitranscriptome modulates memory strength." Cell Research 29, no. 1 (2018): 4–5. http://dx.doi.org/10.1038/s41422-018-0121-8.

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Peer, Eyal, Sharon Moshitch-Moshkovitz, Gideon Rechavi, and Dan Dominissini. "The Epitranscriptome in Translation Regulation." Cold Spring Harbor Perspectives in Biology 11, no. 8 (2018): a032623. http://dx.doi.org/10.1101/cshperspect.a032623.

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Lockhart, Jennifer. "Revealing the Elusive Plant Epitranscriptome." Plant Cell 27, no. 11 (2015): 3019–20. http://dx.doi.org/10.1105/tpc.15.00908.

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Crunkhorn, Sarah. "Targeting the epitranscriptome in AML." Nature Reviews Drug Discovery 18, no. 6 (2019): 420. http://dx.doi.org/10.1038/d41573-019-00079-8.

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Lian, Hao, Qin-Hua Wang, Chang-Bin Zhu, Jie Ma, and Wei-Lin Jin. "Deciphering the Epitranscriptome in Cancer." Trends in Cancer 4, no. 3 (2018): 207–21. http://dx.doi.org/10.1016/j.trecan.2018.01.006.

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Thomas, Justin M., Pedro J. Batista, and Jordan L. Meier. "Metabolic Regulation of the Epitranscriptome." ACS Chemical Biology 14, no. 3 (2019): 316–24. http://dx.doi.org/10.1021/acschembio.8b00951.

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Flamand, Mathieu N., and Kate D. Meyer. "The epitranscriptome and synaptic plasticity." Current Opinion in Neurobiology 59 (December 2019): 41–48. http://dx.doi.org/10.1016/j.conb.2019.04.007.

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Li, Xiaoyu, Qiao-Xia Liang, Jin-Ran Lin, et al. "Epitranscriptomic technologies and analyses." Science China Life Sciences 63, no. 4 (2020): 501–15. http://dx.doi.org/10.1007/s11427-019-1658-x.

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Lombard, Murielle, and Djemel Hamdane. "Flavin-dependent epitranscriptomic world." Archives of Biochemistry and Biophysics 632 (October 2017): 28–40. http://dx.doi.org/10.1016/j.abb.2017.06.011.

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Miano, Valentina, Azzurra Codino, Luca Pandolfini, and Isaia Barbieri. "The non-coding epitranscriptome in cancer." Briefings in Functional Genomics 20, no. 2 (2021): 94–105. http://dx.doi.org/10.1093/bfgp/elab003.

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Abstract Post-synthesis modification of biomolecules is an efficient way of regulating and optimizing their functions. The human epitranscriptome includes a variety of more than 100 modifications known to exist in all RNA subtypes. Modifications of non-coding RNAs are particularly interesting since they can directly affect their structure, stability, interaction and function. Indeed, non-coding RNAs such as tRNA and rRNA are the most modified RNA species in eukaryotic cells. In the last 20 years, new functions of non-coding RNAs have been discovered and their involvement in human disease, incl

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Majumder, Pritha, Biswanath Chatterjee, and C. K. Shen. "Epitranscriptome and FMRP Regulated mRNA Translation." Epigenomes 1, no. 2 (2017): 11. http://dx.doi.org/10.3390/epigenomes1020011.

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Dixit, Sameer, and Samie R. Jaffrey. "Expanding the epitranscriptome: Dihydrouridine in mRNA." PLOS Biology 20, no. 7 (2022): e3001720. http://dx.doi.org/10.1371/journal.pbio.3001720.

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Kouvela, Adamantia, Apostolos Zaravinos, and Vassiliki Stamatopoulou. "Adaptor Molecules Epitranscriptome Reprograms Bacterial Pathogenicity." International Journal of Molecular Sciences 22, no. 16 (2021): 8409. http://dx.doi.org/10.3390/ijms22168409.

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The strong decoration of tRNAs with post-transcriptional modifications provides an unprecedented adaptability of this class of non-coding RNAs leading to the regulation of bacterial growth and pathogenicity. Accumulating data indicate that tRNA post-transcriptional modifications possess a central role in both the formation of bacterial cell wall and the modulation of transcription and translation fidelity, but also in the expression of virulence factors. Evolutionary conserved modifications in tRNA nucleosides ensure the proper folding and stability redounding to a totally functional molecule.

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