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Dissertations / Theses on the topic 'Epoxide hydrolase'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

Kroetz, Deanna L. "Inhibition of human liver microsomal epoxide hydrolase /." Thesis, Connect to this title online; UW restricted, 1990. http://hdl.handle.net/1773/7958.

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2

Wang, Li-Wen. "Directed evolution of the Aspergillus niger epoxide hydrolase." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=981104282.

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3

Maritz, Jana. "The stabilisation of epoxide hydrolase activity / Jana Maritz." Thesis, Potchefstroom University for Christian Higher Education, 2002. http://hdl.handle.net/10394/1478.

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4

Sellers, Kathleen Walworth. "Role of brain soluble epoxide hydrolase in cardiovascular function." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0008356.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 156 pages. Includes Vita. Includes bibliographical references.

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5

Hattori, Nao. "Epoxide hydrolase affects estrogen production in the human ovary." Kyoto University, 2001. http://hdl.handle.net/2433/150184.

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6

Davis, Benjamin Boyce. "Novel treatments for atherosclerosis with inhibitors of soluble epoxide hydrolase /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.

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7

Sandberg, Martin. "Mammalian soluble epoxide hydrolase : studies on gene structure and expression /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 2000. http://epsilon.slu.se/avh/2000/91-576-5747-5.pdf.

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8

Janfalk, Carlsson Åsa. "Towards Understanding of Selectivity & Enantioconvergence of an Epoxide Hydrolase." Doctoral thesis, Uppsala universitet, Institutionen för kemi - BMC, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-286557.

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Epoxide hydrolase I from Solanum tuberosum (StEH1) and isolated variants thereof has been studied for mapping structure-function relationships with the ultimate goal of being able to in silico predict modifications needed for a certain activity or selectivity. To solve this, directed evoultion using CASTing and an ISM approach was applied to improve selectivity towards either of the enantiomeric product diols from (2,3-epoxypropyl)benzene (1). A set of variants showing a range of activites and selectivities was isolated and characterized to show that both enantio- and regioselectivity was chan

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9

Lindberg, Diana. "Exploring Selectivity and Hysteresis : Kinetic Studies on a Potato Epoxide Hydrolase." Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-112285.

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The kinetic mechanism of an α/β hydrolase fold epoxide hydrolase from potato, StEH1, has been studied with the aims of explaining the underlying causes for enantio- and regioselectivity, both being important for product purity. Further effort has been laid upon understanding the causes of a hysteretic behavior discovered in the measurements leading to Paper I. The enantioselectivity was investigated with substrates differing only in substituent size at one carbon of the oxirane ring structure. In catalysis with trans-stilbene oxide and styrene oxide, enantioselectivity is the result of differe

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10

Ali, Ahmed Said. "Investigation of epoxide hydrolase activity in Saccharomyces cerevisiae ORF YNR064c protein." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-203473.

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11

González, Gabriela Desireé Tormet 1987. "Caracterização de epóxido hidrolases do tipo alfa,beta e LEH de actinobactérias do gênero Streptomyces." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/322415.

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Orientador: Luciana Gonzaga de Oliveira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-27T15:18:07Z (GMT). No. of bitstreams: 1 Gonzalez_GabrielaDesireeTormet_M.pdf: 4315214 bytes, checksum: c9035c7fc38805f3a9804bc69a845c1e (MD5) Previous issue date: 2015<br>Resumo: Epóxido-hidrolases pertencem a um amplo grupo de enzimas hidrolíticas encontradas em todos os tipos de organismos vivos, incluindo insetos, plantas e micro-organismos. Agem sobre uma variedade de epóxidos convertendo-os aos respectivos dióis. As epóxido-h

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12

Maritz, Jana. "Red yeast epoxide hydrolases : growth, activity and selectivity / J. Maritz." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1836.

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Enantiopure epoxides are versatile compounds in the production of single enantiomer drugs, and are of high value as building blocks and intermediates in the preparation of more complex single enantiomer pharmaceuticals and agrochemicals. Epoxide hydrolases, ubiquitous enzymes in nature, can be versatile tools in the biocatalytic production of these single enantiomer epoxides due to their capability of selectively hydrolysing one enantiomer of a wide range of these compounds, and thus rendering an enantiopure epoxide and diol. The value of epoxide hydrolases for the kinetic resolution of epoxi

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13

Mueller, Martin J. "Leukotriene A₄ hydrolase : identification of amino acid residues involved in catalyses and substrate-mediated inactivation /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4934-4/.

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14

Tronstad-Elfström, Lisa. "Characterization of Epoxide Hydrolases from Yeast and Potato." Doctoral thesis, Uppsala University, Department of Biochemistry, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5900.

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<p>Epoxides are three-membered cyclic ethers formed in the metabolism of foreign substances and as endogenous metabolites. Epoxide hydrolases (EHs) are enzymes that catalyze the hydrolysis of epoxides to yield the corresponding diols. EHs have been implicated in diverse functions such as detoxification of various toxic epoxides, as well as regulation of signal substance levels.</p><p>The main goal of this thesis was to investigate and characterize the α/β hydrolase fold EH. The first part concerns the identifictaion of an EH in <i>Saccharomyces cerevisiae</i>. The second part involves detailed

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15

Duflot, Thomas. "Rôle de l'époxyde hydrolase soluble dans les maladies cardiovasculaires." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR037.

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L’époxyde hydrolase soluble (sEH) est une enzyme ubiquitaire, bifonctionnelle, codée par le gène EPHX2. La partie hydrolase (sEH-H) est responsable de la dégradation de facteurs endothéliaux vasodilatateurs, les acides époxyeicosatriénoïques (EETs), alors que la partie phosphatase (sEH-P) est impliquée dans le métabolisme des acides lysophosphatidiques (LPAs).L’objectif de ce travail a été de développer des outils méthodologiques permettant d'évaluer le rôle de la sEH dans la physiopathologie des maladies cardiovasculaires.Nous avons développé une méthode de quantification par CLHP-MS² des EET

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16

Micoogullari, Yagmur. "Polymorphisms Of Epoxide Hydrolase Genes And Ischemic Stroke Risk In Turkish Population." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613497/index.pdf.

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Stroke is characterized with loss of one or more functions of the body resulted by inadequate blood supply to the brain. Most of the cases result from a blood clot forms on an atherosclerotic plaque in the brain which is called as ischemic stroke. Structure of the arteries and vascular tone are listed in major determinants in the development of the disorder. Soluble epoxide hydrolase (sEH, EPHX2) catalyzes conversion of epoxyeicosatrienoic acids to inactive diol metabolites. EETs are potent vasodilators that participate in the regulation of vascular tone and cerebral blood flow. Microsomal epo

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17

Mirpourzadeh, Sara. "Development of new mimetics for the Tyr-pair of the Epoxide Hydrolase." Thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235135.

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18

Görlin, Mikaela. "Directed Evolution of Solanum tuberosum Epoxide Hydrolase 1 Toward Extended Substrate Acceptance." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235132.

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19

sun, pengfei. "Characterization of an Epoxide Hydrolase from the Florida Red Tide Dinoflagellate, Karenia brevis." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2066.

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Polyether compounds are a subgroup of natural products with regular occurrence of multiple C-O-C motifs. The biosynthetic origin of polycylic polethers has been studied and the majority of them are derived from polyketide or terpene pathways. Normally, the polycyclic polyethers can be divided into two groups based on their structural features: the first group features multiple rings that are interconnected by carbon-carbon single bond, which are produced by a biosynthetic cascade of exo epoxide-opening reactions; the other group has multiple fused cyclic ethers and are formed by an cascade of

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20

Cheong, Wan-yee Ana. "Regulation and characterization of microsomal epoxide hydrolase (Ephx1) in the female reproductive tract /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38284182.

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21

Cheong, Wan-yee Ana, and 張韻怡. "Regulation and characterization of microsomal epoxide hydrolase (Ephx1) in the female reproductive tract." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B4501114X.

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22

Newman, John William. "Novel tools for the investigation of the endogenous role of soluble epoxide hydrolase /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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23

Varennes, Olivier. "Le rôle de l'Epoxyde hydrolase soluble (sEH) dans la physiopathologie des calcifications vasculaires." Thesis, Amiens, 2018. http://www.theses.fr/2018AMIE0046/document.

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L'Epoxide Hydrolase soluble (sEH) est une enzyme exprimée dans les vaisseaux. Elle possède un domaine hydrolase à l'extrémité COOH-term (sEH-H) qui métabolise des facteurs vasodilatateurs et anti-inflammatoires comme les acides époxyeicosatriénoïques (EETs). Elle possède également un domaine phosphatase à l'extrémité NH2-term (sEH-P) dont le rôle biologique n'est pas totalement élucidé. Afin de comprendre le rôle de sEH-H et sEH-P dans la calcification vasculaire, des anneaux aortiques de rats et des cellules musculaires lisses vasculaires humaines (CMLVh) ont été exposés à des conditions proc

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24

Zhao, Wei. "Further Characterization of Recombinant Epoxide Hydrolase Kau2 Derived from Metagenomic DNA and Application in Biocatalytic Reactions." Thesis, Ecole centrale de Marseille, 2014. http://www.theses.fr/2014ECDM0008/document.

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Les chimistes organiciens disposent à l'heure actuelle des outils de la biocatalyse afin d'accéder aux produits de la chimie fine et en particulier à des synthons et des molécules optiquement enrichies. Dans ce cadre, le travail de thèse présenté dans ce mémoire a été conduit afin d'enrichir notre connaissance sur une époxyde hydrolase (EH) découverte après analyse métagénomique d'un bio-filtre. Afin de pouvoir mener une étude de mutagénèse dirigée de sorte à améliorer certaines propriétés de cette enzyme appelée Kau2-EH, un modèle de l'enzyme a été élaboré sur la base de la structure tridimen

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25

Varennes, Olivier. "Le rôle de l'Epoxyde hydrolase soluble (sEH) dans la physiopathologie des calcifications vasculaires." Electronic Thesis or Diss., Amiens, 2018. http://www.theses.fr/2018AMIE0046.

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L'Epoxide Hydrolase soluble (sEH) est une enzyme exprimée dans les vaisseaux. Elle possède un domaine hydrolase à l'extrémité COOH-term (sEH-H) qui métabolise des facteurs vasodilatateurs et anti-inflammatoires comme les acides époxyeicosatriénoïques (EETs). Elle possède également un domaine phosphatase à l'extrémité NH2-term (sEH-P) dont le rôle biologique n'est pas totalement élucidé. Afin de comprendre le rôle de sEH-H et sEH-P dans la calcification vasculaire, des anneaux aortiques de rats et des cellules musculaires lisses vasculaires humaines (CMLVh) ont été exposés à des conditions proc

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26

Codony, Gisbert Sandra. "From the design to the in vivo evaluation of novel soluble epoxide hydrolase inhibitors." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671480.

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Epoxieicosatrienoic acids acids (EETs) are endogenous chemical mediators derived from arachidonic acid that show anti-inflammatory, antihypertensive, analgesic, angiogenic and antiatherosclerotic effects. Soluble epoxide hydrolase (sEH) converts EETs to their corresponding dihydroxyeicosatrienoic acids, whereby the biological effects of EETs are diminished, eliminated, or altered. Therefore, it has been proposed that inhibition of sEH may have therapeutic effects in various inflammatory and pain-related diseases. A number of very potent sEH inhibitors (sEHIs) have been developed, several of th

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27

Bulleid, Neil J. "Microsomal epoxide hydrolase : investigation of putative isoenzyme forms and mechanism of induction by nitrosamines." Thesis, Glasgow Caledonian University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303813.

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28

Zhao, Wei. "Further Characterization of Recombinant Epoxide Hydrolase Kau2 Derived from Metagenomic DNA and Application in Biocatalytic Reactions." Electronic Thesis or Diss., Ecole centrale de Marseille, 2014. http://www.theses.fr/2014ECDM0008.

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Les chimistes organiciens disposent à l'heure actuelle des outils de la biocatalyse afin d'accéder aux produits de la chimie fine et en particulier à des synthons et des molécules optiquement enrichies. Dans ce cadre, le travail de thèse présenté dans ce mémoire a été conduit afin d'enrichir notre connaissance sur une époxyde hydrolase (EH) découverte après analyse métagénomique d'un bio-filtre. Afin de pouvoir mener une étude de mutagénèse dirigée de sorte à améliorer certaines propriétés de cette enzyme appelée Kau2-EH, un modèle de l'enzyme a été élaboré sur la base de la structure tridimen

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29

Rudberg, Peter C. "Leukotriene A4 hydrolase : studies of structure-function relationships by site-directed mutagenesis and X-ray crystallography /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-038-9/.

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30

Yeates, Charl Alan. "Biocatalytic resolution of substituted styrene oxides / Charl Alan Yeates." Thesis, Potchefstroom University for Christian Higher Education, 2001. http://hdl.handle.net/10394/1489.

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31

Fetterolf, Brandon J. "Synthesis and Analysis of Mechanism Based Inhibitors of Juvenile Hormone Epoxide Hydrolase from Insect Trichoplusia ni." NCSU, 2002. http://www.lib.ncsu.edu/theses/available/etd-20020210-114921.

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<p>AbstractFETTEROLF, BRANDON JOHN. Synthesis and Analysis of Mechanism Based Inhibitors of Juvenile Hormone Epoxide Hydrolase from Insect Trichoplusia ni. (Under the direction of Russell J. Linderman) The research presented here entails a multi-disciplinary advance at understanding the role of juvenile hormone epoxide hydrolase in the metabolism of juvenile hormone in last stadium Trichoplusia ni. The work combines synthetic organic chemistry and biochemistry.A series of juvenile hormone analogs have been synthesized and their effectiveness to inhibit insect JHEH has been ascertained. Some of

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32

Leuillier, Matthieu. "Rôle de l'activité phosphatase de l'époxyde hydrolase soluble dans la régulation de l'homéostasie métabolique et cardiovasculaire. In vivo inactivation of the phosphatase activity of soluble epoxide hydrolase potentiates brown adispose thermogenesis and protects against cardiovascular damage and remodeling Discovery of the first in vivo active inhibitors of the soluble epoxide hydrolase phosphatase domain Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR150.

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Près de 40 ans après sa découverte initiale en 1972, il a été montré en 2003 que l'époxyde hydrolase soluble (sEH), codée par le gène EPHX2, est une protéine bifonctionnelle qui présente non seulement une activité époxyde hydrolase au niveau de sa partie C-terminale mais également une activité lipidophosphatase sur son domaine N-terminal. En effet, au niveau de sa partie C-terminale, l’activité hydrolase métabolise des époxydes d'acides gras polyinsaturés. Notamment, elle transforme les acides époxyeicosatriénoïques, facteurs vasodilatateurs et anti-inflammatoires biologiquement actifs générés

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33

Gurell, Ann. "Biochemical Studies on a Plant Epoxide Hydrolase : Discovery of a Proton Entry and Exit Pathway and the Use of In vitro Evolution to Shift Enantioselectivity." Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122424.

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The work leading to this thesis has provided additional information and novel knowledge concerning structure-function relationship in the potato epoxide hydrolase. Epoxide hydrolases are enzymes catalyzing the hydrolysis of epoxides to yield the corresponding vicinal diols. The reaction mechanism proceeds via a nucleophilic attack resulting in a covalent alkylenzyme intermediate, which in turn is attacked by a base-activated water molecule, followed by product release. Epoxides and diols are precursors in the production of chiral compounds and the use of epoxide hydrolases as biocatalysts is g

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34

Hurst, Susan I. "Roles of cytochromes P450 and microsomal epoxide hydrolase in drug-drug interactions involving valporic acid and its analogues /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7940.

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35

Blum, Maximilian. "Analytik von CYP-Eicosanoiden und ihre Rolle bei ischämischem Organversagen." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21298.

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Cytochrom P450 (CYP) Enzyme tragen zur Bioaktivierung von langkettigen mehrfach ungesättigten Fettsäuren bei. Die gebildeten Monoepoxy- und Monohydroxy-Metaboliten werden zusammenfassend als CYP-Eicosanoide bezeichnet und fungieren als Mediatoren bei der Regulation des Gefäßtonus, der Herz- und Nierenfunktion, sowie einer Vielzahl weiterer physiologischer Prozesse, wobei die biologische Aktivität oftmals abhängig von der Positions- und Stereoisomerie der Eicosanoide ist. Prominente Vertreter der CYP-Eicosanoid-Familie sind die aus der Arachidonsäure gebildeten Epoxyeicosatriensäuren (EETs) und

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36

Kamynina, Alisa. "Furthering the understanding of the redox control of soluble epoxide hydrolase and protein kinase G in the cardiovascular system." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/furthering-the-understanding-of-the-redox-control-of-soluble-epoxide-hydrolase-and-protein-kinase-g-in-the-cardiovascular-system(f6909a1e-6b09-4c3b-8d36-b7e417f45a1d).html.

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Redox regulation of proteins represents an important control mechanism that can finely tune cell homeostasis or responses to stress. Two proteins regulated in this way include soluble epoxide hydrolase (sEH) and protein kinase G (PKG). sEH hydrolyses epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), which are less potent in terms of their ability to dilate blood vessels and lower blood pressure (BP) or induce angiogenesis. Thus inhibitors of sEH, which include lipid electrophiles, that adduct to C521, increase EET levels. As sepsis is a time of oxidative stress when li

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37

Hefke, Lena [Verfasser], Ewgenij [Gutachter] Proschak, and Stefan [Gutachter] Knapp. "Using fingerprints and machine learning tools for the prediction of novel dual active compounds for leukotriene A4 hydrolase and soluble epoxide hydrolase / Lena Hefke ; Gutachter: Ewgenij Proschak, Stefan Knapp." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2020. http://d-nb.info/122685320X/34.

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Wilson, Jewell D. "In vivo and in vitro evidence for the synthesis and processing of a styrene oxide induced form of epoxide hydrolase." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1985. http://digitalcommons.auctr.edu/dissertations/1137.

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In vivo and in vitro studies have been done to determine the site of biosynthesis and processing of styrene oxide (SO) induced epoxide hydrolase (EH). Adult male Long—Evans rats were used to induce a form of epoxide hydrolase using styrene oxide as the inducing agent. Rats were administered 500 milligrams of SO per milliliter of corn oil intraperitoneally per day. They were sacrificed forty-eight hours post-injections and the livers were quickly removed, homogenized and fractionated on a sucrose discontinuous density gradient to obtain the microsomal fraction. Epoxide Hydrolase was synthesized

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39

Smart, Joanne. "Polymorphisms in the CYP1A1, microsomal epoxide hydrolase and the Ah receptor genes : functional significance and relationship to lung cancer susceptibility." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285805.

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40

Beloti, Lilian Luzia 1980. "Estudo funcional de uma epóxido hidrolase de Aspergillus brasiliensis CCT1435 = expressão, purificação e caracterização enzimática = Functional study of an epoxide hydrolase from Aspergillus brasiliensis CCT1435: expression, purification and enzymatic characterization." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316511.

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Orientadores: Anete Pereira de Souza, Valéria Maia Merzel<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-24T03:05:12Z (GMT). No. of bitstreams: 1 Beloti_LilianLuzia_D.pdf: 11283696 bytes, checksum: dfedaea17b072c7d899caa1ccd4e9032 (MD5) Previous issue date: 2013<br>Resumo: O resumo poderá ser visualizado no texto completo da tese digital<br>Abstract: The complete abstract is available with the full electronic document<br>Doutorado<br>Genetica de Microorganismos<br>Doutora em Genética e Biologia Molecular

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Feugray, Guillaume. "Evaluatiοn translatiοnnelle de l’activité phοsphatase de l’épοxyde hydrοlase sοluble au cοurs des maladies cardiοmétabοliques". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMR101.

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L’époxyde hydrolase soluble (sEH) est une enzyme bifonctionnelle codée par le gène EPHX2 et qui présente une activité hydrolase (sEH-H) sur son domaine C-terminal et une activité phosphatase (sEH-P) sur son domaine N-terminal. La sEH-H est impliquée dans le métabolisme des acides gras époxydés et plus particulièrement des acides époxyeicosatriénoïques (EETs). Ils présentent des effets vasodilatateurs, pro-angiogéniques et anti-inflammatoires. Ils sont métabolisés en dérivés diols biologiquement moins actifs par la sEH-H. Actuellement, des inhibiteurs pharmacologiques sont en cours d’investigat

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42

Mavrommatis, Ioannis. "The effects of dietary long chain n-3 polyunsaturated fatty acids on soluble epoxide hydrolase and related markers of cardiovascular health." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=56261.

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43

Amrein, Beat Anton. "Extending the Reach of Computational Approaches to Model Enzyme Catalysis." Doctoral thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-314686.

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Recent years have seen tremendous developments in methods for computational modeling of (bio-) molecular systems. Ever larger reactive systems are being studied with high accuracy approaches, and high-level QM/MM calculations are being routinely performed. However, applying high-accuracy methods to large biological systems is computationally expensive and becomes problematic when conformational sampling is needed. To address this challenge, classical force field based approaches such as free energy perturbation (FEP) and empirical valence bond calculations (EVB) have been employed in this work

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Johnson, Clinton L. "Mechanisms of Prenatal High-Salt "Fetal Programming" Resulting in Stress Hyperresponsiveness in The Adult Female Offspring in The Sprague Dawley Rat." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2830.

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Female offspring of Sprague-Dawley rats fed a high-salt diet (HS) during pregnancy show an enhancement of mean arterial pressure (MAP) and heart rate (HR) response to acute stress in adulthood compared to offspring whose mothers were fed a normal-salt diet (NS) [1]. In the present study, we first examined the expression of soluble epoxide hydrolase (SEH) protein in brain tissue. Whole brains were collected and SEH gene (EPHX2) mRNA and SEH protein expression were analyzed using RT-PCR and Western blot, respectively. mRNA levels were relatively decreased in high-salt rats (1.0 ± 0.32 NS vs 0.39

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Yeates, Charl Alan. "Optimisation of a stereoconvergent process catalysed by whole yeast cells / Charl Alan Yeates." Phd thesis, North-West University, 2008. http://hdl.handle.net/10394/4100.

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Costa, Bruna Zucoloto da 1987. "Processos biocatalíticos aplicando epóxido hidrolases, óxido redutases e transaminases." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249207.

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Orientador: Anita Jocelyne Marsaioli<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-27T18:00:04Z (GMT). No. of bitstreams: 1 Costa_BrunaZucolotoda_D.pdf: 6212345 bytes, checksum: ec8b84a214cbc377e0f9f13d33ddc561 (MD5) Previous issue date: 2011<br>Resumo: Os processos biocatalíticos foram abordados nesta tese de doutorado deste a triagem de micro-organismos para a seleção de biocatalisadores adequados até o uso de enzimas isoladas em reações de interesse biotecnológico. O primeiro capítulo apresenta o isolamento, identifica

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Pham, Minh Hien. "Etudes sur le métabolisme de l'acide flavone-8-acétique (FAA), un composé à visée antivasculaire antitumorale." Paris 5, 2007. http://www.theses.fr/2007PA05P631.

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: L’acide flavone-8-acétique (FAA) est très actif sur les tumeurs solides chez la souris, mais n’a pas montré d'effets anticancéreux chez l’homme. Etant donné que le métabolisme de la FAA pourrait être responsable de cette différence d’activité anticancéreuse, nous avons donc étudié son métabolisme chez la souris et l'homme. Nous avons montré que la FAA est métabolisée par des microsomes murins en 6 nouveaux métabolites de phase I. A comparer aux microsomes humains, la FAA est mieux métabolisée par des microsomes murins en terme de nombre et de quantité de métabolites. Plusieurs cytochromes P4

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Ahmad, Shabbir. "Hysteretic Behavior, Regioselectivity, and Role of Salt Bridging Residues at the Domain Interface of Potato Epoxide Hydrolase StEH1, Site-Directed Mutagenesis and Kinetic Study." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235134.

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Simões, Tiago Henrique Nogueira. "Triagem de enzimas associadas à biotransformação de hidrocarbonetos a partir de metagenoma de sedimentos contaminados com petroléo e metais pesados." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-29042010-101614/.

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A metagenômica trouxe novas perspectivas ao estudo de comunidades microbianas no ambiente, permitindo explorar tanto a diversidade taxonômica de microrganismos ainda não-cultivados, como o acesso direto a genes e vias metabólicas. Neste trabalho, foram construídas bibliotecas metagenômicas a partir de amostras de sedimentos de mangue da Baía de Guanabara (RJ), impactadas com hidrocarbonetos de petróleo e metais pesados. Proteobacteria (33,3%), bactérias afiliadas a redutoras-de-sulfato (29,7%) e Firmicutes (20%) representaram os grupos principais nas amostras ambientais, baseado em análises fi

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Rampasio, Raquel Rodrigues 1986. "Estudos sobre a clonagem e expressão do gene SEH1 (epóxido hidrolase) de Pichia stipitis EM Pichia pastoris." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248442.

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Orientador: Luciana Gonzaga de Oliveira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-22T05:28:22Z (GMT). No. of bitstreams: 1 Rampasio_RaquelRodrigues_M.pdf: 2052024 bytes, checksum: 07f4cd2fcba87af264e6efceab06d527 (MD5) Previous issue date: 2012<br>Resumo: Epóxidos enantiopuros e dióis vicinais têm sido utilizados na síntese de inúeras moléculas bioativas. Dessa forma, as epóxido-hidrolases microbianas capazes de hidrolisar enantioseletivamente epóxidos racêmicos emergiram como uma alternativa promissora na obten

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