Relevant bibliographies by topics / Epoxycholesterol

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Epoxycholesterol'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Epoxycholesterol"

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Wielkoszyński, Tomasz, Jolanta Zalejska-Fiolka, Joanna K. Strzelczyk, et al. "Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals." Mediators of Inflammation 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/2784701.

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Objective. Oxidized cholesterol derivatives are thought to exert atherogenic effect thus adversely affecting vascular endothelium. The aim of the study was to assess the effect of 5α,6α-epoxycholesterol on experimentally induced hypercholesterolemia in rabbits, and the levels of homocysteine (HCY), asymmetric dimethylarginine (ADMA), paraoxonase-1 (PON-1), and inflammatory parameters (IL-6, TNF-α, CRP).Material and methods. The rabbits were divided into 3 groups, 8 animals each, and fed with basic fodder (C), basic fodder plus cholesterol (Ch) or basic fodder plus 5α,6α-epoxycholesterol, and u
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Bjorkhem, Ingemar, and Ulf Diczfalusy. "24(S),25-Epoxycholesterol—A Potential Friend." Arteriosclerosis, Thrombosis, and Vascular Biology 24, no. 12 (2004): 2209–10. http://dx.doi.org/10.1161/01.atv.0000148704.72481.28.

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Wong, Jenny, Carmel M. Quinn, and Andrew J. Brown. "SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR." Biochemical Journal 400, no. 3 (2006): 485–91. http://dx.doi.org/10.1042/bj20060914.

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Cholesterol accumulation and removal are regulated by two different transcription factors. SREBP-2 (sterol-regulatory-element-binding protein-2) is best known to up-regulate genes involved in cholesterol biosynthesis and uptake, whereas LXR (liver X receptor) is best known for up-regulating cholesterol efflux genes. An important cholesterol efflux gene that is regulated by LXR is the ATP-binding cassette transporter, ABCA1 (ATP-binding cassette transporter-A1). We have previously shown that statin treatment down-regulated ABCA1 expression in human macrophages, probably by inhibiting synthesis
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Tomkinson, Nicholas C. O., Timothy M. Willson, Jonathon S. Russel, and Thomas A. Spencer. "Efficient, Stereoselective Synthesis of 24(S),25-Epoxycholesterol." Journal of Organic Chemistry 63, no. 26 (1998): 9919–23. http://dx.doi.org/10.1021/jo981753v.

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Wang, Yuchen, Kersti Karu, Anna Meljon, et al. "24S,25-Epoxycholesterol in mouse and rat brain." Biochemical and Biophysical Research Communications 449, no. 2 (2014): 229–34. http://dx.doi.org/10.1016/j.bbrc.2014.05.012.

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Jaouadi, Oumaima, Inès Limam, Mohamed Abdelkarim, et al. "5,6-Epoxycholesterol Isomers Induce Oxiapoptophagy in Myeloma Cells." Cancers 13, no. 15 (2021): 3747. http://dx.doi.org/10.3390/cancers13153747.

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Multiple myeloma (MM) is an incurable plasma cell malignancy with frequent patient relapse due to innate or acquired drug resistance. Cholesterol metabolism is reported to be altered in MM; therefore, we investigated the potential anti-myeloma activity of two cholesterol derivatives: the 5,6 α- and 5,6 β-epoxycholesterol (EC) isomers. To this end, viability assays were used, and isomers were shown to exhibit important anti-tumor activity in vitro in JJN3 and U266 human myeloma cell lines (HMCLs) and ex vivo in myeloma patients’ sorted CD138+ malignant cells. Moreover, we confirmed that 5,6 α-E
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Wielkoszyński, Tomasz, Jolanta Zalejska-Fiolka, Joanna K. Strzelczyk та ін. "5α,6α-Epoxyphytosterols and 5α,6α-Epoxycholesterol Increase Oxidative Stress in Rats on Low-Cholesterol Diet". Oxidative Medicine and Cellular Longevity 2019 (15 листопада 2019): 1–8. http://dx.doi.org/10.1155/2019/1983975.

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Objective. Cholesterol oxidation products have an established proatherogenic and cytotoxic effect. An increased exposure to these substances may be associated with the development of atherosclerosis and cancers. Relatively little, though, is known about the effect of phytosterol oxidation products, although phytosterols are present in commonly available and industrial food products. Thus, the aim of the research was to assess the effect of 5α,6α-epoxyphytosterols, which are important phytosterol oxidation products, on redox state in rats. Material and Methods. The animals were divided into 3 g
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Fukunaga, Makiko, Satoshi Nunomura, Shigeru Nishida, et al. "Mast cell death induced by 24(S),25-epoxycholesterol." Experimental Cell Research 316, no. 19 (2010): 3272–81. http://dx.doi.org/10.1016/j.yexcr.2010.09.002.

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Brown, Andrew J. "24(S),25-Epoxycholesterol: A messenger for cholesterol homeostasis." International Journal of Biochemistry & Cell Biology 41, no. 4 (2009): 744–47. http://dx.doi.org/10.1016/j.biocel.2008.05.029.

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Tomkinson, Nicholas C. O., Timothy M. Willson, Jonathon S. Russel, and Thomas A. Spencer. "ChemInform Abstract: Efficient, Stereoselective Synthesis of 24(S),25-Epoxycholesterol." ChemInform 30, no. 24 (2010): no. http://dx.doi.org/10.1002/chin.199924197.

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Dissertations / Theses on the topic "Epoxycholesterol"

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Wong, Jenny Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "The role of 24(S),25-epoxycholesterol in cellular cholesterol homeostasis." Awarded by:University of New South Wales. School of Biotechnology & Biomolecular Sciences, 2007. http://handle.unsw.edu.au/1959.4/29398.

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Cellular cholesterol homeostasis ensures that cells are able to acquire enough cholesterol for cellular needs including membrane renewal, but avoid excess accumulation. Cholesterol homeostasis is maintained by two transcription factors, the Sterol Regulatory Element-Binding Protein-2 (SREBP-2) which regulates the genes involved in cholesterol biosynthesis and uptake; and the Liver X Receptor (LXR), which regulates the genes involved in maintaining Reverse Cholesterol Transport (RCT). Both LXR and SREBP-2 are regulated by oxidized cholesterol derivatives, referred to as oxysterols. 24(S),25-
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Telesford, Dana-Marie Leslie-Ann. "Interfacial Behavior of Cholesterol, 7-Ketocholesterol and 5ß,6ß-Epoxycholesterol in Phosphatidylcholine Monolayers." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417701383.

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Gilmore, Ian Richard. "Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells." Thesis, Swansea University, 2013. https://cronfa.swan.ac.uk/Record/cronfa42712.

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Oxysterols are oxygenated derivatives of cholesterol or its precursors. One oxysterol, 24(S),25-epoxycholesterol (24(S),25-EC), which results from a shunt in the cholesterol synthesis pathway has been found at higher than expected levels in embryonic murine brain. Interestingly, the receptor that 24(5),25-EC is a ligand for, Liver X Receptor (LXR), has been implicated in neurogenesis in the ventral mid brain region of embryonic brain; an area with a high density of dopaminergic neurons. The mechanism by which LXR induces this effect is unclear. Therefore, proteomic and phosphoproteomic studies
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Hubler, Zita. "Enhancing Oligodendrocyte Formation via Inhibition of the Cholesterol Biosynthesis Pathway." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1595612178572819.

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Bacelar, Jorge Miguel da Silva. "Anticancer oxysterols." Master's thesis, 2018. http://hdl.handle.net/10316/84572.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>O Mestrado Integrado em Ciências Farmacêuticas (MICF) contempla no seu Plano de Estudos, de acordo com a Diretiva 2013/55/EU, a realização de um Estágio Curricular na área da Farmácia Comunitária que permite ao estudante pôr em prática em contexto de trabalho o conhecimento adquirido ao longo do curso, assim como também adquirir novas competências. O estágio realizado na Farmácia Santa Isabel, sob a orientação da Dr.ª Ana Baptista, e compreendeu a duração de 641h. O presente relatório, p
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