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Journal articles on the topic 'Epoxycholesterol'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Wielkoszyński, Tomasz, Jolanta Zalejska-Fiolka, Joanna K. Strzelczyk, et al. "Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals." Mediators of Inflammation 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/2784701.

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Objective. Oxidized cholesterol derivatives are thought to exert atherogenic effect thus adversely affecting vascular endothelium. The aim of the study was to assess the effect of 5α,6α-epoxycholesterol on experimentally induced hypercholesterolemia in rabbits, and the levels of homocysteine (HCY), asymmetric dimethylarginine (ADMA), paraoxonase-1 (PON-1), and inflammatory parameters (IL-6, TNF-α, CRP).Material and methods. The rabbits were divided into 3 groups, 8 animals each, and fed with basic fodder (C), basic fodder plus cholesterol (Ch) or basic fodder plus 5α,6α-epoxycholesterol, and u

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2

Bjorkhem, Ingemar, and Ulf Diczfalusy. "24(S),25-Epoxycholesterol—A Potential Friend." Arteriosclerosis, Thrombosis, and Vascular Biology 24, no. 12 (2004): 2209–10. http://dx.doi.org/10.1161/01.atv.0000148704.72481.28.

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3

Wong, Jenny, Carmel M. Quinn, and Andrew J. Brown. "SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR." Biochemical Journal 400, no. 3 (2006): 485–91. http://dx.doi.org/10.1042/bj20060914.

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Cholesterol accumulation and removal are regulated by two different transcription factors. SREBP-2 (sterol-regulatory-element-binding protein-2) is best known to up-regulate genes involved in cholesterol biosynthesis and uptake, whereas LXR (liver X receptor) is best known for up-regulating cholesterol efflux genes. An important cholesterol efflux gene that is regulated by LXR is the ATP-binding cassette transporter, ABCA1 (ATP-binding cassette transporter-A1). We have previously shown that statin treatment down-regulated ABCA1 expression in human macrophages, probably by inhibiting synthesis

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4

Tomkinson, Nicholas C. O., Timothy M. Willson, Jonathon S. Russel, and Thomas A. Spencer. "Efficient, Stereoselective Synthesis of 24(S),25-Epoxycholesterol." Journal of Organic Chemistry 63, no. 26 (1998): 9919–23. http://dx.doi.org/10.1021/jo981753v.

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5

Wang, Yuchen, Kersti Karu, Anna Meljon, et al. "24S,25-Epoxycholesterol in mouse and rat brain." Biochemical and Biophysical Research Communications 449, no. 2 (2014): 229–34. http://dx.doi.org/10.1016/j.bbrc.2014.05.012.

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6

Jaouadi, Oumaima, Inès Limam, Mohamed Abdelkarim, et al. "5,6-Epoxycholesterol Isomers Induce Oxiapoptophagy in Myeloma Cells." Cancers 13, no. 15 (2021): 3747. http://dx.doi.org/10.3390/cancers13153747.

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Multiple myeloma (MM) is an incurable plasma cell malignancy with frequent patient relapse due to innate or acquired drug resistance. Cholesterol metabolism is reported to be altered in MM; therefore, we investigated the potential anti-myeloma activity of two cholesterol derivatives: the 5,6 α- and 5,6 β-epoxycholesterol (EC) isomers. To this end, viability assays were used, and isomers were shown to exhibit important anti-tumor activity in vitro in JJN3 and U266 human myeloma cell lines (HMCLs) and ex vivo in myeloma patients’ sorted CD138+ malignant cells. Moreover, we confirmed that 5,6 α-E

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7

Wielkoszyński, Tomasz, Jolanta Zalejska-Fiolka, Joanna K. Strzelczyk та ін. "5α,6α-Epoxyphytosterols and 5α,6α-Epoxycholesterol Increase Oxidative Stress in Rats on Low-Cholesterol Diet". Oxidative Medicine and Cellular Longevity 2019 (15 листопада 2019): 1–8. http://dx.doi.org/10.1155/2019/1983975.

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Objective. Cholesterol oxidation products have an established proatherogenic and cytotoxic effect. An increased exposure to these substances may be associated with the development of atherosclerosis and cancers. Relatively little, though, is known about the effect of phytosterol oxidation products, although phytosterols are present in commonly available and industrial food products. Thus, the aim of the research was to assess the effect of 5α,6α-epoxyphytosterols, which are important phytosterol oxidation products, on redox state in rats. Material and Methods. The animals were divided into 3 g

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8

Fukunaga, Makiko, Satoshi Nunomura, Shigeru Nishida, et al. "Mast cell death induced by 24(S),25-epoxycholesterol." Experimental Cell Research 316, no. 19 (2010): 3272–81. http://dx.doi.org/10.1016/j.yexcr.2010.09.002.

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9

Brown, Andrew J. "24(S),25-Epoxycholesterol: A messenger for cholesterol homeostasis." International Journal of Biochemistry & Cell Biology 41, no. 4 (2009): 744–47. http://dx.doi.org/10.1016/j.biocel.2008.05.029.

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10

Tomkinson, Nicholas C. O., Timothy M. Willson, Jonathon S. Russel, and Thomas A. Spencer. "ChemInform Abstract: Efficient, Stereoselective Synthesis of 24(S),25-Epoxycholesterol." ChemInform 30, no. 24 (2010): no. http://dx.doi.org/10.1002/chin.199924197.

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11

Soules, Regis, Emmanuel Noguer, Luigi Iuliano та ін. "Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS". Chemistry and Physics of Lipids 207 (жовтень 2017): 92–98. http://dx.doi.org/10.1016/j.chemphyslip.2017.05.006.

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12

Wooten, Joshua S., Huaizhu Wu, Joe Raya, Xiaoyuan Dai Perrard, John Gaubatz, and Ron C. Hoogeveen. "The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL/6J Mice." Cholesterol 2014 (February 5, 2014): 1–11. http://dx.doi.org/10.1155/2014/843468.

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Our current understanding of oxysterol metabolism during different disease states such as obesity and dyslipidemia is limited. Therefore, the aim of this study was to determine the effect of diet-induced obesity on the tissue distribution of various oxysterols and the mRNA expression of key enzymes involved in oxysterol metabolism. To induce obesity, male C57BL/6J mice were fed a high fat-cholesterol diet for 24 weeks. Following diet-induced obesity, plasma levels of 4β-hydroxycholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, 7α-hydroxycholesterol, 7β-hydroxycholesterol, and 27-hydrox

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13

Yamamuro, Daisuke, Hisataka Yamazaki, Jun-ichi Osuga та ін. "Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT". Journal of Lipid Research 61, № 9 (2020): 1287–99. http://dx.doi.org/10.1194/jlr.ra119000512.

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The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols in 206 healthy volunteers and 8 individuals with genetic LCAT deficiency, including familial LCAT deficiency (FLD) and fish-eye disease (FED). In the healthy volunteers, the mean values of the ester-to-total molar ratios of the following sterols varied: 4β-hydroxycholesterol (4βHC), 0.38; 5,6α-epoxycholesterol (5,6αEC), 0.46; 5,6β-epoxycholesterol (5

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14

Sinensky, Michael, Judy Logel, Seloka Phirwa, Apurba K. Gayen, and Thomas A. Spencer. "Requirement for 24(S),25-epoxycholesterol for the viability of cultured fibroblasts." Experimental Cell Research 171, no. 2 (1987): 492–97. http://dx.doi.org/10.1016/0014-4827(87)90180-7.

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15

Pincinato, Eder de Carvalho, Patricia Moriel, and Dulcinéia Saes Parra Abdalla. "Cholesterol oxides inhibit cholesterol esterification by lecithin: cholesterol acyl transferase." Brazilian Journal of Pharmaceutical Sciences 45, no. 3 (2009): 429–35. http://dx.doi.org/10.1590/s1984-82502009000300007.

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Cholesterol oxides are atherogenic and can affect the activity of diverse important enzymes for the lipidic metabolism. The effect of 7β-hydroxycholesterol, 7-ketocholesterol, 25-hydroxycholesterol, cholestan-3β,5α,6β-triol,5,6β-epoxycholesterol, 5,6α-epoxycholesterol and 7α-hydroxycholesterol on esterification of cholesterol by lecithin:cholesterol acyl transferase (LCAT, EC 2.3.1.43) and the transfer of esters of cholesterol oxides from high density lipoprotein (HDL) to low density lipoproteins (LDL) and very low density lipoproteins (VLDL) by cholesteryl ester transfer protein (CETP) was in

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16

Wong, Jenny, Carmel M. Quinn, Ingrid C. Gelissen, and Andrew J. Brown. "Endogenous 24(S),25-Epoxycholesterol Fine-tunes Acute Control of Cellular Cholesterol Homeostasis." Journal of Biological Chemistry 283, no. 2 (2007): 700–707. http://dx.doi.org/10.1074/jbc.m706416200.

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17

Saucier, Sandra E., Andrew A. Kandutsch, Dawn S. Clark, and Thomas A. Spencer. "Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1166, no. 1 (1993): 115–23. http://dx.doi.org/10.1016/0005-2760(93)90291-g.

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18

Wielkoszyński, Tomasz, Jolanta Zalejska-Fiolka, Joanna K. Strzelczyk та ін. "5α,6α-Epoxyphytosterols and 5α,6α-Epoxycholesterol Increase Nitrosative Stress and Inflammatory Cytokine Production in Rats on Low-Cholesterol Diet". Oxidative Medicine and Cellular Longevity 2020 (8 червня 2020): 1–9. http://dx.doi.org/10.1155/2020/4751803.

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Objective. Oxidized cholesterol derivatives are compounds with proven atherogenic and mutagenic effects. However, little is known about the effect of oxidized plant sterol derivatives (oxyphytosterols), whose structure is similar to the one of oxycholesterols. Our previous studies indicate that they have a similar profile of action, e.g., both exacerbate disorder of lipid metabolism and oxidative stress in experimental animals. The aim of the present study was to assess the effect of epoxycholesterol and epoxyphytosterols (mainly sitosterol) on the severity of nitrosative stress and the concen

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19

Bobrowska-Korczak, Barbara, Agnieszka Stawarska, Arkadiusz Szterk, Karol Ofiara, Małgorzata Czerwonka, and Joanna Giebułtowicz. "Determination of Pharmaceuticals, Heavy Metals, and Oxysterols in Fish Muscle." Molecules 26, no. 5 (2021): 1229. http://dx.doi.org/10.3390/molecules26051229.

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The present study aimed to assess the levels of 98 multi-class pharmaceuticals including cardiovascular drugs, antidepressants, hypnotics, antibiotics, and sulfonamides occurring in the muscle tissue of fish caught in the Baltic Sea. The following fish species were collected: perch (Perca fluviatilis); flounder (Platichthys flesus); turbot (Scophthalmus maximus); plaice (Pleuronectes platessa); cod (Gadus morhua callarias); bream (Abramis brama); crucian (Carassius carassius). Additionally, in the examined fish muscle the levels of heavy metals and trace elements were determined (As; Ag; Au; B

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20

Poirot, Marc, and Sandrine Silvente-Poirot. "When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite1." Biochemical Society Transactions 44, no. 2 (2016): 631–37. http://dx.doi.org/10.1042/bst20150232.

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Dendrogenin A (DDA) is the first steroidal alkaloid (SA) to be identified in human tissues to date and arises from the stereoselective enzymatic conjugation of 5,6α-epoxycholesterol (5,6α-EC) with histamine (HA). DDA induces the re-differentiation of cancer cells in vitro and in vivo and prevents breast cancer (BC) and melanoma development in mice, evidencing its protective role against oncogenesis. In addition, DDA production is lower in BCs compared with normal tissues, suggesting a deregulation of its biosynthesis during carcinogenesis. The discovery of DDA reveals the existence of a new me

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21

Saucier, S. E., A. A. Kandutsch, F. R. Taylor, T. A. Spencer, S. Phirwa, and A. K. Gayen. "Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts." Journal of Biological Chemistry 260, no. 27 (1985): 14571–79. http://dx.doi.org/10.1016/s0021-9258(17)38606-4.

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22

Berrodin, Thomas J., Qi Shen, Elaine M. Quinet, Matthew R. Yudt, Leonard P. Freedman та Sunil Nagpal. "Identification of 5α,6α-Epoxycholesterol as a Novel Modulator of Liver X Receptor Activity". Molecular Pharmacology 78, № 6 (2010): 1046–58. http://dx.doi.org/10.1124/mol.110.065193.

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23

Wong, Jenny, Carmel M. Quinn, Gilles Guillemin, and Andrew J. Brown. "Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis." Journal of Neurochemistry 103, no. 5 (2007): 1764–73. http://dx.doi.org/10.1111/j.1471-4159.2007.04913.x.

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24

Zerenturk, Eser J., Ika Kristiana, Saloni Gill, and Andrew J. Brown. "The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821, no. 9 (2012): 1269–77. http://dx.doi.org/10.1016/j.bbalip.2011.11.009.

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25

Ouimet, Mireille, Ming-Dong Wang, Natalie Cadotte, Kenneth Ho, and Yves L. Marcel. "Epoxycholesterol Impairs Cholesteryl Ester Hydrolysis in Macrophage Foam Cells, Resulting in Decreased Cholesterol Efflux." Arteriosclerosis, Thrombosis, and Vascular Biology 28, no. 6 (2008): 1144–50. http://dx.doi.org/10.1161/atvbaha.107.157115.

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26

Phillips, Richard, Ryan Smith, Kosuke Funato, et al. "PDTM-04. THERAPEUTIC MODULATION OF CHOLESTEROL HOMEOSTASIS IN DIPG THROUGH MASSIVE GENERATION OF 24,25-EPOXYCHOLESTEROL." Neuro-Oncology 20, suppl_6 (2018): vi204. http://dx.doi.org/10.1093/neuonc/noy148.846.

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27

Spencer, T. A., A. K. Gayen, S. Phirwa, et al. "24(S),25-Epoxycholesterol. Evidence consistent with a role in the regulation of hepatic cholesterogenesis." Journal of Biological Chemistry 260, no. 25 (1985): 13391–94. http://dx.doi.org/10.1016/s0021-9258(17)38732-x.

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28

Telesford, Dana-Marie, Dominique Verreault, Victoria Reick-Mitrisin та Heather C. Allen. "Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers". Langmuir 31, № 36 (2015): 9859–69. http://dx.doi.org/10.1021/acs.langmuir.5b02539.

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29

Khripach, V. A., V. N. Zhabinskii, A. V. Antonchick, and A. P. Antonchick. "Synthesis of (24S)-hydroxy-and (24S)-24,25-epoxycholesterol analogues, potential agonists of nuclear LXR receptors." Russian Journal of Bioorganic Chemistry 32, no. 6 (2006): 586–94. http://dx.doi.org/10.1134/s1068162006060124.

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30

Meynier, Alexandra, Jeanine Lherminier, Joelle Demaison-Meloche, Christian Ginies, Andre Grandgirard, and Luc Demaison. "Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters." British Journal of Nutrition 87, no. 5 (2002): 447–58. http://dx.doi.org/10.1079/bjn2002555.

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The aim of this study was to evaluate the effect of dietary oxysterols on coronary atherosclerosis and vasospasm. Golden Syrian hamsters were fed three diets with different lipid contents for 3 months: (1) a normolipidaemic diet containing 25 g corn oil–fish oil (4:1, w/w)/kg (group Low L); (2) a hyperlipidaemic diet composed of the normolipidaemic diet supplemented with 150 g lard+30 g cholesterol/kg (group High L); (3) a third diet, similar to the hyperlipidaemic diet, in which 4 g cholesterol/kg was replaced by a mixture of oxysterols (group High L+OS). The oxysterol mixture contained (g/kg

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31

Theofilopoulos, Spyridon, Willy Antoni Abreu de Oliveira, Shanzheng Yang, et al. "24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo." Journal of Biological Chemistry 294, no. 11 (2019): 4169–76. http://dx.doi.org/10.1074/jbc.ra118.005639.

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32

Spencer, Thomas A., Dansu Li, Jonathon S. Russel, Nicholas C. O. Tomkinson, and Timothy M. Willson. "Further Studies on the Synthesis of 24(S),25-Epoxycholesterol. A New, Efficient Preparation of Desmosterol." Journal of Organic Chemistry 65, no. 7 (2000): 1919–23. http://dx.doi.org/10.1021/jo991370c.

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33

ECHARTE, MAIDER, DIANA ANSORENA, and ICIAR ASTIASARAN. "Fatty Acid Modifications and Cholesterol Oxidation in Pork Loin during Frying at Different Temperatures." Journal of Food Protection 64, no. 7 (2001): 1062–66. http://dx.doi.org/10.4315/0362-028x-64.7.1062.

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The effect of frying with sunflower oil for 4 min at different temperatures (160, 170, and 180°C) on fatty acids and cholesterol of pork loin meat was studied. Total fat content increased from 5.6% in fresh loin to 7.3, 7.8, and 12.1% at 160, 170, and 180°C, respectively. Interactions with culinary fat gave rise to a significant increase in unsaturated acids/saturated acids and polyunsaturated acids/saturated acids ratios, which could be considered an advantage from a nutritional point of view. Less than 1 ppm (μg/g of sample) of cholesterol oxidation products was detected in fresh loin, where

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34

Phillips, Richard E., Yanhong Yang, Ryan C. Smith, et al. "Target identification reveals lanosterol synthase as a vulnerability in glioma." Proceedings of the National Academy of Sciences 116, no. 16 (2019): 7957–62. http://dx.doi.org/10.1073/pnas.1820989116.

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Diffuse intrinsic pontine glioma (DIPG) remains an incurable childhood brain tumor for which novel therapeutic approaches are desperately needed. Previous studies have shown that the menin inhibitor MI-2 exhibits promising activity in preclinical DIPG and adult glioma models, although the mechanism underlying this activity is unknown. Here, using an integrated approach, we show that MI-2 exerts its antitumor activity in glioma largely independent of its ability to target menin. Instead, we demonstrate that MI-2 activity in glioma is mediated by disruption of cholesterol homeostasis, with suppr

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35

Rowe, Andrea H., Carmen A. Argmann, Jane Y. Edwards, et al. "Enhanced Synthesis of the Oxysterol 24( S ),25-Epoxycholesterol in Macrophages by Inhibitors of 2,3-Oxidosqualene:Lanosterol Cyclase." Circulation Research 93, no. 8 (2003): 717–25. http://dx.doi.org/10.1161/01.res.0000097606.43659.f4.

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36

Shirouchi, Bungo, Yumiko Furukawa, Yuri Nakamura та ін. "Inhibition of Niemann-Pick C1-Like 1 by Ezetimibe Reduces Dietary 5β,6β-Epoxycholesterol Absorption in Rats". Cardiovascular Drugs and Therapy 33, № 1 (2019): 35–44. http://dx.doi.org/10.1007/s10557-019-06854-4.

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37

Corey, E. J., and Michael J. Grogan. "Stereocontrolled syntheses of 24(S),25-epoxycholesterol and related oxysterols for studies on the activation of LXR receptors." Tetrahedron Letters 39, no. 51 (1998): 9351–54. http://dx.doi.org/10.1016/s0040-4039(98)02181-9.

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38

Spencer, Thomas A., Dansu Li, Jonathon S. Russel, Nicholas C. O. Tomkinson, and Timothy M. Willson. "ChemInform Abstract: Further Studies on the Synthesis of 24(S),25-Epoxycholesterol. A New, Efficient Preparation of Desmosterol." ChemInform 31, no. 29 (2010): no. http://dx.doi.org/10.1002/chin.200029152.

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39

Beyea, Michael M., Claire L. Heslop, Cynthia G. Sawyez, et al. "Selective Up-regulation of LXR-regulated GenesABCA1,ABCG1, andAPOEin Macrophages through Increased Endogenous Synthesis of 24(S),25-Epoxycholesterol." Journal of Biological Chemistry 282, no. 8 (2006): 5207–16. http://dx.doi.org/10.1074/jbc.m611063200.

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40

Guo, Fenghua, Wenting Hong, Mingjie Yang, et al. "Upregulation of 24(R/S),25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells." Biochemical and Biophysical Research Communications 504, no. 4 (2018): 892–98. http://dx.doi.org/10.1016/j.bbrc.2018.09.058.

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41

Orczewska-Dudek, Sylwia, Dorota Bederska-Łojewska, Marek Pieszka, and Mariusz Pietras. "Cholesterol and Lipid Peroxides in Animal Products and Health Implications - A Review." Annals of Animal Science 12, no. 1 (2012): 25–52. http://dx.doi.org/10.2478/v10220-012-0003-9.

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Cholesterol and Lipid Peroxides in Animal Products and Health Implications - A ReviewThe level of oxysterols in animal products depends on the temperature used in food processing, duration of heating, and storage time and conditions. High temperature, oxygen, exposure to light, chemical composition of the product and low level of antioxidants accelerate the formation of cholesterol oxidation products (COPs). Also the high content of polyunsaturated fatty acids in meat and eggs favours the formation of oxysterols. Dairy products are characterized by the lowest content of COPs of all animal prod

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42

Griffiths, William J., Ian Gilmore, Eylan Yutuc та ін. "Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation". Journal of Lipid Research 59, № 6 (2018): 1058–70. http://dx.doi.org/10.1194/jlr.d083246.

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7-Oxocholesterol (7-OC), 5,6-epoxycholesterol (5,6-EC), and its hydrolysis product cholestane-3β,5α,6β-triol (3β,5α,6β-triol) are normally minor oxysterols in human samples; however, in disease, their levels may be greatly elevated. This is the case in plasma from patients suffering from some lysosomal storage disorders, e.g., Niemann-Pick disease type C, or the inborn errors of sterol metabolism, e.g., Smith-Lemli-Opitz syndrome and cerebrotendinous xanthomatosis. A complication in the analysis of 7-OC and 5,6-EC is that they can also be formed ex vivo from cholesterol during sample handling

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43

Javitt, Norman B. "Alzheimer's Disease: Neuroprogesterone, Epoxycholesterol, and ABC Transporters as Determinants of Neurodesmosterol Tissue Levels and its Role in Amyloid Protein Processing." Journal of Alzheimer's Disease 35, no. 3 (2013): 441–50. http://dx.doi.org/10.3233/jad-130044.

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44

Corey, E. J., and Michael J. Grogan. "ChemInform Abstract: Stereocontrolled Syntheses of 24(S),25-Epoxycholesterol and Related Oxysterols for Studies on the Activation of LXR Receptors." ChemInform 30, no. 10 (2010): no. http://dx.doi.org/10.1002/chin.199910196.

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45

Wong, Jenny, Carmel M. Quinn, and Andrew J. Brown. "Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol." Lipids in Health and Disease 6, no. 1 (2007): 10. http://dx.doi.org/10.1186/1476-511x-6-10.

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46

Hong, Yi-Fan, Hangeun Kim, Hye Sun Kim, Woo Jung Park, Joo-Yun Kim, and Dae Kyun Chung. "Lactobacillus acidophilus K301 Inhibits Atherogenesis via Induction of 24 (S), 25-Epoxycholesterol-Mediated ABCA1 and ABCG1 Production and Cholesterol Efflux in Macrophages." PLOS ONE 11, no. 4 (2016): e0154302. http://dx.doi.org/10.1371/journal.pone.0154302.

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47

Meljon, Anna, Peter J. Crick, Eylan Yutuc, et al. "Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5." Biomolecules 9, no. 4 (2019): 149. http://dx.doi.org/10.3390/biom9040149.

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Deficiency in cytochrome P450 (CYP) 7B1, also known as oxysterol 7α-hydroxylase, in humans leads to hereditary spastic paraplegia type 5 (SPG5) and in some cases in infants to liver disease. SPG5 is medically characterized by loss of motor neurons in the corticospinal tract. In an effort to gain a better understanding of the fundamental biochemistry of this disorder, we have extended our previous profiling of the oxysterol content of brain and plasma of Cyp7b1 knockout (-/-) mice to include, amongst other sterols, 25-hydroxylated cholesterol metabolites. Although brain cholesterol levels do no

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Dollis, Daniele, and Francis Schuber. "Effects of A 2,3-oxidosqualene-lanosterol cyclase inhibitor, 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2." Biochemical Pharmacology 48, no. 1 (1994): 49–57. http://dx.doi.org/10.1016/0006-2952(94)90222-4.

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49

Rubis, Blazej, Anna Paszel, Mariusz Kaczmarek, Magdalena Rudzinska, Henryk Jelen, and Maria Rybczynska. "Beneficial or harmful influence of phytosterols on human cells?" British Journal of Nutrition 100, no. 6 (2008): 1183–91. http://dx.doi.org/10.1017/s0007114508981423.

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Abstract:

So far, a protective influence of phytosterols on the human organism and atherogenesis has been suggested. Most studies have concentrated on the cytotoxic efficacy of phytosterols on cancer cells. However, there are only a few reports showing their influence on normal cells. The aim of the present study was to determine whether dietary plant sterols and their thermal processing products could influence the viability of normal, abdominal endothelial cells that play a crucial role in atherogenesis. Thus, we studied the effect of rapeseed oil-extract components, β-sitosterol, cholesterol and thei

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Medina, Philippe, Khadijetou Diallo, Emilie Huc‐Claustre, et al. "The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets." British Journal of Pharmacology, August 23, 2020. http://dx.doi.org/10.1111/bph.15205.

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