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Journal articles on the topic 'Eriodictyon, chemistry'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Taguchi, N., T. Hata, E. Kamiya, et al. "Eriodictyon angustifolium extract, but not Eriodictyon californicum extract, reduces human hair greying." International Journal of Cosmetic Science 42, no. 4 (2020): 336–45. http://dx.doi.org/10.1111/ics.12620.

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2

Liu, Yong-Long, David K. Ho, John M. Cassady, Vanessa M. Cook, and William M. Baird. "Isolation of Potential Cancer Chemopreventive Agents from Eriodictyon californicum." Journal of Natural Products 55, no. 3 (1992): 357–63. http://dx.doi.org/10.1021/np50081a012.

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3

Ley, Jakob P., Gerhard Krammer, Gerald Reinders, Ian L. Gatfield, and Heinz-Jürgen Bertram. "Evaluation of Bitter Masking Flavanones from Herba Santa (Eriodictyon californicum(H. & A.) Torr., Hydrophyllaceae)." Journal of Agricultural and Food Chemistry 53, no. 15 (2005): 6061–66. http://dx.doi.org/10.1021/jf0505170.

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4

Reichelt, Katharina V., Beate Hartmann, Berthold Weber, Jakob P. Ley, Gerhard E. Krammer, and Karl-Heinz Engel. "Identification of Bisprenylated Benzoic Acid Derivatives from Yerba Santa (Eriodictyon ssp.) Using Sensory-Guided Fractionation." Journal of Agricultural and Food Chemistry 58, no. 3 (2010): 1850–59. http://dx.doi.org/10.1021/jf903286s.

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5

Vega-Villa, Karina R., Jaime A. Yáñez, Connie M. Remsberg, Yusuke Ohgami, and Neal M. Davies. "Stereospecific high-performance liquid chromatographic validation of homoeriodictyol in serum and Yerba Santa (Eriodictyon glutinosum)." Journal of Pharmaceutical and Biomedical Analysis 46, no. 5 (2008): 971–74. http://dx.doi.org/10.1016/j.jpba.2007.07.020.

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6

Richards, Allie, and Savita Chaurasia. "Antioxidant Activity and Reactive Oxygen Species (ROS) Scavenging Mechanism of Eriodictyon californium, an Edible Herb of North America." Journal of Chemistry 2022 (October 4, 2022): 1–8. http://dx.doi.org/10.1155/2022/6980121.

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Modern life associated with processed food, exposure to a wide range of pollutants, physical inactivity, unprecedented time, excessive involvement of technology in our lives, and so on give rise to oxidative stress which threatens our physical and mental health. Because of rising healthcare costs and mistrust of conventional medicine, mankind is looking for alternatives to over-the-counter medications and prescription drugs, which is driving the demand for nutraceuticals across the globe. Antioxidant-rich plant-based natural products could be an important source of nutraceuticals to boost endo

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7

Reichelt, Katharina V., Beate Hartmann, Berthold Weber, Jakob P. Ley, Gerhard E. Krammer, and Karl-Heinz Engel. "Correction to Identification of Bisprenylated Benzoic Acid Derivatives from Yerba Santa (Eriodictyon ssp.) Using Sensory-Guided Fractionation." Journal of Agricultural and Food Chemistry 58, no. 6 (2010): 3868. http://dx.doi.org/10.1021/jf100539f.

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8

Elhady, Sameh S., Elsayed A. Ibrahim, Marwa S. Goda та ін. "GC-MS/MS Quantification of EGFR Inhibitors, β-Sitosterol, Betulinic Acid, (+) Eriodictyol, (+) Epipinoresinol, and Secoisolariciresinol, in Crude Extract and Ethyl Acetate Fraction of Thonningia sanguinea". Molecules 27, № 13 (2022): 4109. http://dx.doi.org/10.3390/molecules27134109.

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Medicinal plants are widely used in folk medicine to treat various diseases. Thonningia sanguinea Vahl is widespread in African traditional medicine, and exhibits antioxidant, antibacterial, antiviral, and anticancer activities. T. sanguinea is a source of phytomedicinal agents that have previously been isolated and structurally elucidated. Herein, gas chromatography combined with tandem mass spectrometry (GC-MS/MS) was used to quantify epipinoresinol, β-sitosterol, eriodictyol, betulinic acid, and secoisolariciresinol contents in the methanolic crude extract and its ethyl acetate fraction for

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9

Kiene, Mats, Svenja Blum, Gerold Jerz, and Peter Winterhalter. "A Comparison between High-Performance Countercurrent Chromatography and Fast-Centrifugal Partition Chromatography for a One-Step Isolation of Flavonoids from Peanut Hulls Supported by a Conductor like Screening Model for Real Solvents." Molecules 28, no. 13 (2023): 5111. http://dx.doi.org/10.3390/molecules28135111.

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Peanut hulls (Arachis hypogaea, Leguminosae), which are a side stream of global peanut processing, are rich in bioactive flavonoids such as luteolin, eriodictyol, and 5,7-dihydroxychromone. This study aimed to isolate these flavonoid derivatives by liquid-liquid chromatography with as few steps as possible. To this end, luteolin, eriodictyol and 5,7-dihydroxychromone were isolated from peanut hulls using two different techniques, high-performance countercurrent chromatography (HPCCC) and fast-centrifugal partition chromatography (FCPC). The suitability of the biphasic solvent system composed o

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10

Magadán-Corpas, Patricia, Suhui Ye, Álvaro Pérez-Valero, et al. "Optimized De Novo Eriodictyol Biosynthesis in Streptomyces albidoflavus Using an Expansion of the Golden Standard Toolkit for Its Use in Actinomycetes." International Journal of Molecular Sciences 24, no. 10 (2023): 8879. http://dx.doi.org/10.3390/ijms24108879.

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Eriodictyol is a hydroxylated flavonoid displaying multiple pharmaceutical activities, such as antitumoral, antiviral or neuroprotective. However, its industrial production is limited to extraction from plants due to its inherent limitations. Here, we present the generation of a Streptomyces albidoflavus bacterial factory edited at the genome level for an optimized de novo heterologous production of eriodictyol. For this purpose, an expansion of the Golden Standard toolkit (a Type IIS assembly method based on the Standard European Vector Architecture (SEVA)) has been created, encompassing a co

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11

Islam, Anowarul, Md Sadikul Islam, Md Khalesur Rahman, Md Nazim Uddin, and Md Rashedunnabi Akanda. "The pharmacological and biological roles of eriodictyol." Archives of Pharmacal Research 43, no. 6 (2020): 582–92. http://dx.doi.org/10.1007/s12272-020-01243-0.

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12

Klaiklay, Saranyoo, Yaowapa Sukpondma, Vatcharin Rukachaisirikul, Nongporn Hutadilok-Towatana, and Kanokphorn Chareonrat. "Flavanone glucuronides from the leaves of Garcinia prainiana." Canadian Journal of Chemistry 89, no. 4 (2011): 461–64. http://dx.doi.org/10.1139/v10-168.

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Phytochemical investigation of Garcinia prainiana ’s leaves led to the isolation of prainianonide (1), a new flavanone glucuronide, together with six known compounds: (2S)-eriodictyol 7-O-β-d-glucuronide (2), naringenin 7-O-β-d-glucuronide (3), (–)-GB-1a (4), (+)-morelloflavone (5), amenthoflavone (6), and friedelin (7). Their structures were elucidated by spectroscopic methods. The absolute configuration of 1 was determined by circular dichroism spectroscopy. Compounds 4 and 5 showed significant antioxidant activity.

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13

Yáñez, Jaime A., Nicole D. Miranda, Connie M. Remsberg, Yusuke Ohgami, and Neal M. Davies. "Stereospecific high-performance liquid chromatographic analysis of eriodictyol in urine." Journal of Pharmaceutical and Biomedical Analysis 43, no. 1 (2007): 255–62. http://dx.doi.org/10.1016/j.jpba.2006.06.027.

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14

Lee, Jae Kwon. "Anti-inflammatory effects of eriodictyol in lipopolysaccharidestimulated raw 264.7 murine macrophages." Archives of Pharmacal Research 34, no. 4 (2011): 671–79. http://dx.doi.org/10.1007/s12272-011-0418-3.

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15

YOO, Jung-Min, Ji-Hee KIM, Sae-Jin PARK, Yeo-Jin KANG, and Tack-Joong KIM. "Inhibitory Effect of Eriodictyol on IgE/Ag-Induced Type I Hypersensitivity." Bioscience, Biotechnology, and Biochemistry 76, no. 7 (2012): 1285–90. http://dx.doi.org/10.1271/bbb.110952.

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16

Habtemariam, Solomon, and Ermias Dagne. "Comparative Antioxidant, Prooxidant and Cytotoxic Activity of Sigmoidin A and Eriodictyol." Planta Medica 76, no. 06 (2009): 589–94. http://dx.doi.org/10.1055/s-0029-1240604.

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17

Liu, Hui, Hong-cheng Wang, Su-ying Wu, Xian-hui Jia, and Wen-zhao Tang. "Interaction of diplacone and eriodictyol with DNA by multi-spectroscopic and molecular modelling methods." Journal of Molecular Structure 1256 (May 2022): 132536. http://dx.doi.org/10.1016/j.molstruc.2022.132536.

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18

Dos Santos Szewczyk, Katarzyna, Wioleta Pietrzak, Katarzyna Klimek, Anna Grzywa-Celińska, Rafał Celiński, and Marek Gogacz. "LC-ESI-MS/MS Identification of Biologically Active Phenolics in Different Extracts of Alchemilla acutiloba Opiz." Molecules 27, no. 3 (2022): 621. http://dx.doi.org/10.3390/molecules27030621.

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Liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS) qualitative and quantitative analysis of different extracts from the aerial parts and roots of Alchemilla acutiloba led to the identification of phenolic acids and flavonoids. To the best of our knowledge, isorhamnetin 3-glucoside, kaempferol 3-rutinoside, narcissoside, naringenin 7-glucoside, 3-O-methylquercetin, naringenin, eriodictyol, rhamnetin, and isorhamnetin were described for the first time in Alchemilla genus. In addition, the antioxidant, anti-inflammatory and cytotoxic activity of all extracts we

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19

Chobot, Vladimir, Franz Hadacek, Gert Bachmann, Wolfram Weckwerth, and Lenka Kubicova. "Pro- and Antioxidant Activity of Three Selected Flavan Type Flavonoids: Catechin, Eriodictyol and Taxifolin." International Journal of Molecular Sciences 17, no. 12 (2016): 1986. http://dx.doi.org/10.3390/ijms17121986.

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20

Ciric, Ana, Anastasia Karioti, Jasmina Glamoclija, Marina Sokovic, and Helen Skaltsa. "Antimicrobial activity of secondary metabolites isolated from Centaurea spruneri Boiss.& Heldr." Journal of the Serbian Chemical Society 76, no. 1 (2011): 27–34. http://dx.doi.org/10.2298/jsc100127008c.

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Two coumarins, scopoletin (1) and isoscopoletin (2), two simple phenolic acids, protocatechuic acid (3) and isovanillic acid (4) and one flavonoid, eriodictyol (5) were isolated from the aerial parts of Centaurea spruneri. The structure of the compounds was established by spectroscopic methods. The in vitro antimicrobial activity of the isolated compounds was tested against eight bacteria and eight fungal species, using a microdilution method. All compounds tested showed moderate antibacterial and antifungal activities. Their minimum inhibitory concentrations were in the range 0.655 - 2.38 ?mo

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21

Cai, Wan-Ling, Ling Liu, Xue-Qing Liao, Kai-Li Tao, Fang Feng, and Gong-Jun Yang. "Determination of Eriodictyol by a Modified Multi-Walled Carbon Nanotube Glassy Carbon Electrode." Analytical Letters 49, no. 10 (2016): 1502–12. http://dx.doi.org/10.1080/00032719.2015.1113423.

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22

Zhang, Yue, Xia Lei, Hongdan Xu, et al. "Tissue Distribution of Total Flavonoids Extracts of Drynariae Rhizoma in Young and Old Rats by UPLC–MS/MS Determination." Journal of Analytical Methods in Chemistry 2022 (February 4, 2022): 1–30. http://dx.doi.org/10.1155/2022/2447945.

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Drynariae Rhizoma (Kunze ex Mett.) J. Sm. has been extensively used in China, Japan, and Korea to treat osteoporosis and tonify kidneys. A rapid and validated UPLC-MS/MS method for simultaneous determination of the seven analytes including neoeriocitrin, luteolin-7-O-β-D-glucoside, astragalin, naringin, eriodictyol, naringenin, and kaempferol in rats’ various tissues (heart, liver, spleen, lung, kidney, stomach, brain, uterus, ovary, and small intestine) using quercetin as the internal standard (IS) was developed after oral administration of TFDR to rats. Tissues samples were retreated by prot

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23

Guo, Pengli, Mengnan Zeng, Shengchao Wang та ін. "Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome". Molecules 27, № 8 (2022): 2488. http://dx.doi.org/10.3390/molecules27082488.

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(1) Alzheimer’s disease (AD) is a neurodegenerative disorder, and it is now widely accepted that neuroinflammation plays a key role in its pathogenesis. Eriodictyol (Eri) and homoeriodictyol (Hom), dihydroflavonoids extracted from a variety of plants, have been confirmed to display a relationship with neuroprotection. (2) Methods: An AD mouse model was constructed by intracerebroventricular (ICV) injection of the Aβ25–35 peptide, and Eri and Hom were administered orally for 4 weeks. UPLC-MS/MS was used to determine whether Eri and Hom cross the blood–brain barrier to exert their therapeutic ef

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24

Kwon, Eun-Young, and Myung-Sook Choi. "Dietary Eriodictyol Alleviates Adiposity, Hepatic Steatosis, Insulin Resistance, and Inflammation in Diet-Induced Obese Mice." International Journal of Molecular Sciences 20, no. 5 (2019): 1227. http://dx.doi.org/10.3390/ijms20051227.

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The present study aimed to investigate the molecular mechanisms underlying the anti-obesity effect of flavonoid eriodictyol (ED) supplementation in mice fed with a high-fat diet (HFD). C57BL/6N mice were fed with normal diet (ND), HFD (40 kcal% fat), or HFD + 0.005% (w/w) ED for 16 weeks. In HFD-induced obese mice, dietary ED supplementation significantly alleviated dyslipidemia and adiposity by downregulating the expression of lipogenesis-related genes in white adipose tissue (WAT), while enhancing fecal lipid excretion. ED additionally improved hepatic steatosis and decreased the production

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25

Lee, Mina, та Sun-Yup Shim. "Inhibitory Effects of Eriodictyol-7-O-β-d-glucuronide and 5,7-Dihydroxy-4-chromene Isolated from Chrysanthemum zawadskii var. latilobum in FcεRI-Mediated Human Basophilic KU812F Cell Activation". Molecules 25, № 4 (2020): 994. http://dx.doi.org/10.3390/molecules25040994.

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Chrysanthemum zawadskii var. latilobum (CZL) has been used in Eastern medicine for the treatment of various diseases, such as pneumonia, bronchitis, cough, the common cold, pharyngitis, bladder-related disorders, gastroenteric disorders, and hypertension. In the present study, we isolated two strong antiallergic compounds from CZL, namely, eriodictyol-7-O-β-d-glucuronide (EDG) and 5,7-dihydroxy-4-chromene (DC), and investigated their antiallergic effects in FcεRI-mediated human basophilic KU812F cells. EDG and DC downregulated the protein and messenger RNA (mRNA) expression of FcεRI on the cel

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26

Płonka, Joanna, Joanna Szablińska-Piernik, Bogusław Buszewski, Irena Baranowska, and Lesław B. Lahuta. "Analyses of Antioxidative Properties of Selected Cyclitols and Their Mixtures with Flavanones and Glutathione." Molecules 27, no. 1 (2021): 158. http://dx.doi.org/10.3390/molecules27010158.

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The conditions for determining the antioxidant properties of cyclitols (d-pinitol, l-quebrachitol, myo-, l-chiro-, and d-chiro-inositol), selected flavanones (hesperetin, naringenin, eriodictyol, and liquiritigenin) and glutathione by spectrophotometric methods—CUPRAC and with DPPH radical, and by a chromatographic method DPPH-UHPLC-UV, have been identified. Interactions of the tested compounds and their impact on the ox-red properties were investigated. The RSA (%) of the compounds tested was determined. Very low antioxidative properties of cyclitols, compared with flavanones and glutathione

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27

Gonzales, Alecsanndra L., Steven Kuan-Hua Huang, Ureah Thea A. Sevilla, Cheng-Yang Hsieh, and Po-Wei Tsai. "In Silico Analysis of Anti-Inflammatory and Antioxidant Properties of Bioactive Compounds from Crescentia cujete L." Molecules 28, no. 8 (2023): 3547. http://dx.doi.org/10.3390/molecules28083547.

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Crescentia cujete is widely known as a medical plant with broad indigenous ethnomedicinal uses, including anti-inflammatory, and antioxidant. Despite being used for remedies and ethnomedicinal purposes, the benefits obtained from C. cujete still need to be fully utilized. The underwhelming studies on its pharmacological potential, bioactive compounds, and mechanism of action keep the pharmacological and new drug discovery progress of this plant slow. This study focuses on the incorporation of in silico analyses such as ADME prediction and molecular docking simulations on the bioactive compound

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28

Shah, Mohibullah, Sadia Pervaiz, Iqra Ahmad, et al. "Computer-aided discovery of dual-target compounds for Alzheimer’s from ayurvedic medicinal plants." PLOS One 20, no. 6 (2025): e0325441. https://doi.org/10.1371/journal.pone.0325441.

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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline, driven by the accumulation of amyloid-beta plaques and neurofibrillary tangles. It involves the dysfunction of key enzymes such as Acetylcholinesterase (AChE) and β-secretase (BACE1), making them critical targets for therapeutic intervention. In this study we investigated an in-house library of 820 secondary metabolites obtained from Ayurvedic plants against AChE and BACE1 with the aim to discover novel leads for AD. Virtual screening resulted in 15 ligands, mostly belonging to the ursane-type or damma

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29

Fujimura, Yoshinori, Konatsu Fujino, Takanori Yoshimoto, et al. "Eriodictyol-Amplified 67-kDa Laminin Receptor Signaling Potentiates the Antiallergic Effect of O-Methylated Catechin." Journal of Natural Products 84, no. 6 (2021): 1823–30. http://dx.doi.org/10.1021/acs.jnatprod.1c00337.

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30

Oh, Ui Hyeon, Da-Hye Kim, Jungwhoi Lee, Song-I. Han, and Jae-Hoon Kim. "Eriodictyol induces apoptosis via regulating phosphorylation of JNK, ERK, and FAK/AKT in pancreatic cancer cells." Journal of Applied Biological Chemistry 65, no. 2 (2022): 83–88. http://dx.doi.org/10.3839/jabc.2022.011.

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31

Cardullo, Nunzio, Vera Muccilli, Vincenzo Cunsolo, and Corrado Tringali. "Mass Spectrometry and 1H-NMR Study of Schinopsis lorentzii (Quebracho) Tannins as a Source of Hypoglycemic and Antioxidant Principles." Molecules 25, no. 14 (2020): 3257. http://dx.doi.org/10.3390/molecules25143257.

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The ethyl acetate extract of the commercial tannin Tan’Activ QS-SOL (from Schinopsis lorentzii wood), employed for the production of red wine, was subjected to chromatography on Sephadex LH-20, providing nine fractions (A-1–A-9), which were estimated for total phenols content (GAE), antioxidant activity (DPPH, ORAC), and hypoglycemic activity (α-glucosidase and α-amylase inhibition). All the fractions were analyzed by means of HPLC/ESI-MS/MS and 1H-NMR to identify the principal active constituents. Fractions A-1 and A-3 showed the highest antioxidant activity and gallic acid (1), pyrogallol (3

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32

Cortés-Chitala, María del Carmen, Héctor Flores-Martínez, Ignacio Orozco-Ávila, et al. "Identification and Quantification of Phenolic Compounds from Mexican Oregano (Lippia graveolens HBK) Hydroethanolic Extracts and Evaluation of Its Antioxidant Capacity." Molecules 26, no. 3 (2021): 702. http://dx.doi.org/10.3390/molecules26030702.

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Plants have been used for thousands of years for various purposes because they have a wide variety of activities with biological significance. Mexican oregano is an aromatic plant of great importance to Mexico and north of Jalisco state as a spice with important economic value. Chromatographic identification and quantification of phenolic compounds and evaluation of their antioxidant activity were important tools to obtain a better characterization of this spice. Phytochemical analysis indicated the presence of flavonoids, triterpenes, saponins, quinones and tannins, the latter at high concent

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33

Xu, Xiaoyu, Meng Xia, Yang Han, et al. "Highly Promiscuous Flavonoid Di-O-glycosyltransferases from Carthamus tinctorius L." Molecules 29, no. 3 (2024): 604. http://dx.doi.org/10.3390/molecules29030604.

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Safflower (Carthamus tinctorius L.) has been recognized for its medicinal value, but there have been limited studies on the glycosyltransferases involved in the biosynthesis of flavonoid glycosides from safflower. In this research, we identified two highly efficient flavonoid O-glycosyltransferases, CtOGT1 and CtOGT2, from safflower performing local BLAST alignment. By constructing a prokaryotic expression vector, we conducted in vitro enzymatic reactions and discovered that these enzymes were capable of catalyzing two-step O-glycosylation using substrates such as kaempferol, quercetin, and er

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34

Shrestha, Shyam Sharan, Stefania Sut, Serena Barbon Di Marco, et al. "Phytochemical Fingerprinting and In Vitro Bioassays of the Ethnomedicinal Fern Tectaria coadunata (J. Smith) C. Christensen from Central Nepal." Molecules 24, no. 24 (2019): 4457. http://dx.doi.org/10.3390/molecules24244457.

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Tectaria coadunata, an ethnomedicinal fern used in Nepal to treat a large number of diseases, has been poorly studied with regard to its phytochemical composition and possible bioactivity. This study was performed with the aim of supporting traditional medicine as a new source of bioactive constituents. Phytochemical compositions of methanol extracts were determined by nuclear magnetic resonance (NMR), liquid chromatography–diode array detector–mass spectrophotometry (LC-DAD-MS), and liquid chromatography–fluorescence–mass spectrometry. Quali-quantitative data revealed large amount of procyani

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35

Fujimura, Yoshinori, Motofumi Kumazoe, and Hirofumi Tachibana. "67-kDa Laminin Receptor-Mediated Cellular Sensing System of Green Tea Polyphenol EGCG and Functional Food Pairing." Molecules 27, no. 16 (2022): 5130. http://dx.doi.org/10.3390/molecules27165130.

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The body is equipped with a “food factor-sensing system” that senses food factors, such as polyphenols, sulfur-containing compounds, and vitamins, taken into the body, and plays an essential role in manifesting their physiological effects. For example, (–)-epigallocatechin-3-O-gallate (EGCG), the representative catechin in green tea (Camellia sinensi L.), exerts various effects, including anti-cancer, anti-inflammatory, and anti-allergic effects, when sensed by the cell surficial protein 67-kDa laminin receptor (67LR). Here, we focus on three representative effects of EGCG and provide their sp

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36

Wang, Tao, Qingjun Zou, Qiaosheng Guo, Feng Yang, Liwei Wu, and Wenyan Zhang. "Widely Targeted Metabolomics Analysis Reveals the Effect of Flooding Stress on the Synthesis of Flavonoids in Chrysanthemum morifolium." Molecules 24, no. 20 (2019): 3695. http://dx.doi.org/10.3390/molecules24203695.

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Chrysanthemum morifolium. cv “Hangju” is an important medicinal material with many functions in China. Flavonoids as the main secondary metabolites are a major class of medicinal components in “Hangju” and its composition and content can change significantly after flooding. This study mimicked the flooding stress of “Hangju” during flower bud differentiation and detected its metabolites in different growth stages. From widely targeted metabolomics data, 661 metabolites were detected, of which 46 differential metabolites exist simultaneously in the different growth stages of “Hangju”. The top t

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37

Li, Wei, Tae In Kim, Ji Hye Kim, and Hwan-Suck Chung. "Immune Checkpoint PD-1/PD-L1 CTLA-4/CD80 are Blocked by Rhus verniciflua Stokes and its Active Compounds." Molecules 24, no. 22 (2019): 4062. http://dx.doi.org/10.3390/molecules24224062.

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The bark of Rhus verniciflua Stokes (RVS) has been used to treat cancer in Korean herbal medicine. When we screened for PD-1 and CTLA-4 immune checkpoint inhibitors (PD-1/PD-L1 CTLA-4/CD80) from around 800 herbal extracts using competitive Enzyme-Linked Immunosorbent Assay (ELISA), we found that RVS blocked both the PD-1/PD-L1 and the CTLA-4/CD80 interactions. To identify the active compounds from RVS, we performed bioactivity-guided fractionation, and the ethyl acetate (EtOAc) fraction of RVS proved to be the most effective at blocking the PD-1/PD-L1 and CTLA-4/CD80 interactions. In addition,

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38

Kim, Dae-Woon, Won-Jae Lee, Yoseph Asmelash Gebru, et al. "Comparison of Bioactive Compounds and Antioxidant Activities of Maclura tricuspidata Fruit Extracts at Different Maturity Stages." Molecules 24, no. 3 (2019): 567. http://dx.doi.org/10.3390/molecules24030567.

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Abstract: Maclura tricuspidata fruit contains various bioactive compounds and has traditionally been used in folk medicine and as valuable food material in Korea. The composition and contents of bioactive compounds in the fruit can be influenced by its maturity stages. In this study, total phenol, total flavonoid, individual polyphenolic compounds, total carotenoids and antioxidant activities at four maturity stages of the fruit were determined. Polyphenolic compounds were analyzed using high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-QTOF-MS) and HPLC. Am

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Park, Hye Lin, Jae Chul Lee, Kyungha Lee, et al. "Biochemical Characterization of a Flavonoid O-methyltransferase from Perilla Leaves and Its Application in 7-Methoxyflavonoid Production." Molecules 25, no. 19 (2020): 4455. http://dx.doi.org/10.3390/molecules25194455.

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Methylation is a common structural modification that can alter and improve the biological activities of natural compounds. O-Methyltransferases (OMTs) catalyze the methylation of a wide array of secondary metabolites, including flavonoids, and are potentially useful tools for the biotechnological production of valuable natural products. An OMT gene (PfOMT3) was isolated from perilla leaves as a putative flavonoid OMT (FOMT). Phylogenetic analysis and sequence comparisons showed that PfOMT3 is a class II OMT. Recombinant PfOMT3 catalyzed the methylation of flavonoid substrates, whereas no methy

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Liu, Hongxia, Lefei Wang, Mingyue Xu, Benliang Deng, Hui Liu, and Xusheng Zhao. "Phytochemical analysis of Ziziphus jujube leaf at different foliar ages based on widely targeted metabolomics." Open Chemistry 20, no. 1 (2022): 1485–93. http://dx.doi.org/10.1515/chem-2022-0243.

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Abstract Based on metabolomics, the metabolites of Jujube leaves LS1 (one bud and two leaves), LS2 (one bud and three leaves), and LS3 (one bud and four leaves) were taken and examined by ultra-high performance liquid chromatography-mass spectrometry technique. There were 22 substance categories that were identified. Principal component analysis was also utilized to distinguish the metabolomics at the three different foliar ages, and the results suggested that the samples at different foliar ages were clearly separated, demonstrating that the metabolites in the three foliar ages were significa

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Han, Narae, Jin Young Lee, Mihyang Kim, et al. "Effect of Electron-Beam Irradiation on Functional Compounds and Biological Activities in Peanut Shells." Molecules 28, no. 21 (2023): 7258. http://dx.doi.org/10.3390/molecules28217258.

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Peanut shells, rich in antioxidants, remain underutilized due to limited research. The present study investigated the changes in the functional compound content and skin aging-related enzyme inhibitory activities of peanut shells by electron-beam treatment with different sample states and irradiation doses. In addition, phenolic compounds in the peanut shells were identified and quantified using ultra-performance liquid chromatography with ion mobility mass spectrometry–quadrupole time-of-flight and high-performance liquid chromatography with a photodiode array detector, respectively. Total ph

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Murata, Motoki, Yuki Shimizu, Yuki Marugame, et al. "EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol." Journal of Natural Medicines 74, no. 4 (2020): 673–79. http://dx.doi.org/10.1007/s11418-020-01417-6.

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Wang, Longji, Xiubing Ma, Haixiang Ruan, et al. "Optimization of the Biosynthesis of B-Ring Ortho-Hydroxy Lated Flavonoids Using the 4-Hydroxyphenylacetate 3-Hydroxylase Complex (HpaBC) of Escherichia coli." Molecules 26, no. 10 (2021): 2919. http://dx.doi.org/10.3390/molecules26102919.

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Flavonoids are important plant metabolites that exhibit a wide range of physiological and pharmaceutical functions. Because of their wide biological activities, such as anti-inflammatory, antioxidant, antiaging and anticancer, they have been widely used in foods, nutraceutical and pharmaceuticals industries. Here, the hydroxylase complex HpaBC was selected for the efficient in vivo production of ortho-hydroxylated flavonoids. Several HpaBC expression vectors were constructed, and the corresponding products were successfully detected by feeding naringenin to vector-carrying strains. However, wh

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Shubina, Victoria S., Victoria I. Kozina, and Yuri V. Shatalin. "A Comparative Study of the Inhibitory Effect of Some Flavonoids and a Conjugate of Taxifolin with Glyoxylic Acid on the Oxidative Burst of Neutrophils." International Journal of Molecular Sciences 24, no. 20 (2023): 15068. http://dx.doi.org/10.3390/ijms242015068.

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During the storage, processing, and digestion of flavonoid-rich foods and beverages, a condensation of flavonoids with toxic carbonyl compounds occurs. The effect of the resulting products on cells remains largely unknown. The aim of the present study was to evaluate the effects of quercetin, taxifolin, catechin, eriodictyol, hesperetin, naringenin, and a condensation product of taxifolin with glyoxylic acid on the oxidative burst of neutrophils. It was found that the flavonoids and the condensation product inhibited the total production of ROS. Flavonoids decreased both the intra and extracel

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Krzyzanowska, Justyna, Bogdan Janda, Lukasz Pecio, et al. "Determination of Polyphenols in Mentha longifolia and M. piperita Field-Grown and In Vitro Plant Samples Using UPLC-TQ-MS." Journal of AOAC INTERNATIONAL 94, no. 1 (2011): 43–50. http://dx.doi.org/10.1093/jaoac/94.1.43.

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Abstract Nine polyphenols in the aerial parts of Mentha longifolia have been separated by chromatographic techniques. Their structures have been confirmed by HPLC/electrospray ionization-MS/MS. The compounds identified included rosmarinic acid, salvianolic acid L, dedihydro–salvianolic acid, luteolin–glucuronide, luteolin–diglucuronide, luteolin–glucopyranosyl–rhamnopyranoside, and eriodictyol–glucopyranosyl–rhamnopyranoside. The extracts of M. longifolia and M. piperita field plants, in vitro plants, callus tissues, and cell suspension cultures were profiled, and their polyphenol composition

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Zhumakanova, Bagda Sagynaikyzy, Izabela Korona-Głowniak, Krystyna Skalicka-Woźniak, et al. "Phytochemical Fingerprinting and In Vitro Antimicrobial and Antioxidant Activity of the Aerial Parts of Thymus marschallianus Willd. and Thymus seravschanicus Klokov Growing Widely in Southern Kazakhstan." Molecules 26, no. 11 (2021): 3193. http://dx.doi.org/10.3390/molecules26113193.

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The chemical composition of the hydroethanolic extracts (60% v/v) from the aerial parts of Thymus marschallianus Willd (TM) and Thymus seravschanicus Klokov (TS) from Southern Kazakhstan flora was analyzed together with their hexane fractions. Determination of antibacterial, antifungal and antioxidant activities of both extracts was also performed. RP-HPLC/PDA and HPLC/ESI-QTOF-MS showed that there were some differences between the composition of both extracts. The most characteristic components of TM were rosmarinic acid, protocatechuic acid, luteolin 7-O-glucoside, and apigenin 7-O-glucuroni

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Li, Weixi, Rongping Huang, Shaocong Han, et al. "Potential of Tamarind Shell Extract against Oxidative Stress In Vivo and In Vitro." Molecules 28, no. 4 (2023): 1885. http://dx.doi.org/10.3390/molecules28041885.

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Tamarind shell is rich in flavonoids and exhibits good biological activities. In this study, we aimed to analyze the chemical composition of tamarind shell extract (TSE), and to investigate antioxidant capacity of TSE in vitro and in vivo. The tamarind shells were extracted with 95% ethanol refluxing extraction, and chemical constituents were determined by ultra-performance chromatography–electrospray tandem mass spectrometry (UPLC-MS/MS). The free radical scavenging activity of TSE in vitro was evaluated using the oxygen radical absorbance capacity (ORAC) method. The antioxidative effects of

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Cai, Rongxin, Xican Li, Chunhou Li, et al. "Standards-Based UPLC-Q-Exactive Orbitrap MS Systematically Identifies 36 Bioactive Compounds in Ampelopsis grossedentata (Vine Tea)." Separations 9, no. 11 (2022): 329. http://dx.doi.org/10.3390/separations9110329.

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Ampelopsis grossedentata (vine tea) has been used as a detoxifying beverage in China for centuries. To systematically identify its bioactive compounds, the study adopted standards-based ultra-high-performance liquid chromatography coupled with quadrupole/electrostatic field orbitrap high-resolution mass spectrometry (UPLC-Q-Exactive Orbitrap MS) analysis. The analysis was conducted under a negative ion model and the data were collected using the Xcalibur 4.1 software package. Based on comparisons with authentic standards, 36 bioactive compounds were putatively identified by four parameters: re

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Potter, Colin M., and David L. Jones. "Polyphenolic Profiling of Green Waste Determined by UPLC-HDMSE." Processes 9, no. 5 (2021): 824. http://dx.doi.org/10.3390/pr9050824.

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Valorising green waste will greatly enhance and promote the sustainable management of this large volume resource. One potential way to achieve this is the extraction of high value human health promoting chemicals (e.g., polyphenols) from this material. Our primary aim was to identify the main polyphenols present in four contrasting green waste feedstocks, namely Smyrnium olusatrum, Urtica dioica, Allium ursinum and Ulex europaeus, using UPLC-HDMSE. Polyphenol-rich Camellia sinensis (green tea) was used as a reference material. Samples were extracted and analysed by UPLC-HDMSE, which was follow

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Gharibi, Shima, Adam Matkowski, Danial Sarfaraz, et al. "Identification of Polyphenolic Compounds Responsible for Antioxidant, Anti-Candida Activities and Nutritional Properties in Different Pistachio (Pistacia vera L.) Hull Cultivars." Molecules 28, no. 12 (2023): 4772. http://dx.doi.org/10.3390/molecules28124772.

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The use of by-products from the agri-food industry is a promising approach for production of value-added, polyphenol-rich dietary supplements or natural pharmaceutical preparations. During pistachio nut processing, a great amount of husk is removed, leaving large biomass for potential re-use. The present study compares antiglycative, antioxidant, and antifungal activities as well as nutritional values of 12 genotypes belonging to four pistachio cultivars. Antioxidant activity was measured using DPPH and ABTS assays. Antiglycative activity was evaluated as inhibition of advanced glycation end p

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