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Journal articles on the topic 'Erlenmeyer Azlactone Synthesis'

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1

Karade, N. N., S. G. Shirodkar, B. M. Dhoot, and P. B. Waghmare. "Montmorillonite K-10 mediated Erlenmeyer synthesis of 4-arylmethylene-2-phenyl-5(4H)-oxazolones." Journal of Chemical Research 2005, no. 1 (January 2005): 46–47. http://dx.doi.org/10.3184/0308234053431176.

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Aromatic aldehydes and hippuric acid in acetic anhydride undergoes classical Erlenmeyer synthesis in the presence of a catalytic amount of Montmorillonite K-10 to afford the corresponding azlactones in excellent yields with high selectivity. The azlactone formation does not proceed in the absence of either acetic anhydride or Montmorillonite.
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2

Shafiee, Behnaz, Laleh Hadian, and Ahmad R. Khosropour. "An innovation for development of Erlenmeyer–Plöchl reaction and synthesis of AT-130 analogous: a new application of continuous-flow method." RSC Advances 6, no. 24 (2016): 19861–66. http://dx.doi.org/10.1039/c6ra00301j.

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3

Chandrasekhar, Sosale, and Phaneendrasai Karri. "Aromaticity in azlactone anions and its significance for the Erlenmeyer synthesis." Tetrahedron Letters 47, no. 32 (August 2006): 5763–66. http://dx.doi.org/10.1016/j.tetlet.2006.06.006.

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4

Chandrasekhar, Sosale, and Phaneendrasai Karri. "Erlenmeyer azlactone synthesis with aliphatic aldehydes under solvent-free microwave conditions." Tetrahedron Letters 48, no. 5 (January 2007): 785–86. http://dx.doi.org/10.1016/j.tetlet.2006.11.174.

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5

Verma, Tarawanti, Manish Sinha, and Nitin Bansal. "Synthesis of Novel 1,2-Dihydro-1,2,4-Triazin-6(5H)-one Derivatives as Anticancer Agents." Current Bioactive Compounds 16, no. 7 (October 28, 2020): 1116–31. http://dx.doi.org/10.2174/1573407215666191022123310.

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Introduction: Cancer is still an untreatable disease and the second leading cause of death globally. The heterocyclic compounds have always played a major role in the anticancer drug discovery program. 1,2,4-Triazine-6-ones is a heterocyclic privileged structure with diversified activities. In the presented study, 21 novel 2,5-disubstituted-3-phenyl-1,2-dihydro-1,2,4-triazin-6 (5H)-one derivatives (13(a-k), 18(a-j) and 21(a1-a4, b)) have been synthesized and tested for their anticancer activity. Methods: The 2,5-disubstituted-3-phenyl-1,2-dihydro-1,2,4-triazin-6(5H)-one derivatives (13(a-k), 18(a-j) and 21(a1-a4, b) were synthesized by refluxing substituted-2-phenyloxazol-5(4H)-one and hydrazine derivatives. Substituted aldehydes were synthesized via Vilsmeier-Haack reaction, while substituted- 2-phenyloxazol-5(4H)-one derivatives were synthesized by Erlenmeyer Plochl azlactone synthesis. Twenty-one compounds were selected and screened at the National Cancer Institute (NCI), USA, for anticancer activity at a single high dose (10-5M) in full NCI 60 cell panel assay. Results and Conclusion: The selected compounds (13a, 13b, 13c, 13f, 13h, 13i, 13j, 18h, 18i, 21a4) were found to be active against different cancer cell lines. The compound, 5-((5-chloro-3-methyl-1- phenyl-1H-pyrazol-4-yl)methylene)-2-(4-nitrobenzoyl)-3-phenyl-1,2-dihydro-1,2,4-triazin-6(5H)-one (13a) was found to be a potent anti-cancer agent as electron-rich moiety on phenyl at position 2 of triazine nucleus, having a great impact on anticancer activity.
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6

Parveen, Mehtab, Faheem Ahmad, Ali Mohammed Malla, Shaista Azaz, Manuela Ramos Silva, and P. S. Pereira Silva. "[Et3NH][HSO4]-mediated functionalization of hippuric acid: an unprecedented approach to 4-arylidene-2-phenyl-5(4H)-oxazolones." RSC Advances 5, no. 65 (2015): 52330–46. http://dx.doi.org/10.1039/c5ra09290f.

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7

Jagadale, Megha, Altafhusen Naikwade, Rajashri Salunkhe, Mohan Rajmane, and Gajanan Rashinkar. "An ionic liquid gel: a heterogeneous catalyst for Erlenmeyer–Plochl and Henry reactions." New Journal of Chemistry 42, no. 13 (2018): 10993–1005. http://dx.doi.org/10.1039/c8nj00367j.

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8

Zhou, Baocheng, and Wenxing Chen. "The Zwitterionic Imidazolium Salt: First Used for Synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones under Solvent-Free Conditions." Journal of Chemistry 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/280585.

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The zwitterionic imidazolium salt was prepared and characterized by1H NMR. It was first used for synthesis of azlactones via Erlenmeyer synthesis from aromatic aldehydes and hippuric acid under solvent-free conditions. It was found that aldehyde substituents play an important role in these reactions. Better conversions and therefore higher isolated yields were observed when electron-withdrawing groups (EWG-) were present in the aromatic aldehyde. Opposite results were shown when electron-donating groups (EDG-) were present in the aromatic aldehyde. However, azlactones were obtained in moderate to high yields.
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9

El-Mekabaty, Ahmed. "ChemInform Abstract: Erlenmeyer Azlactones. Synthesis, Reactions and Biological Activity." ChemInform 44, no. 34 (August 1, 2013): no. http://dx.doi.org/10.1002/chin.201334216.

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10

Kiyani, Hamzeh, and Shiva Aslanpour. "Synthesis of Erlenmeyer-Plöchl Azlactones Promoted by 5-Sulfosalicylic Acid." HETEROCYCLES 94, no. 7 (2017): 1314. http://dx.doi.org/10.3987/com-17-13711.

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11

Conway, Philip A., Kevin Devine, and Francesca Paradisi. "A simple and efficient method for the synthesis of Erlenmeyer azlactones." Tetrahedron 65, no. 15 (April 2009): 2935–38. http://dx.doi.org/10.1016/j.tet.2009.02.011.

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12

Parveen, Mehtab, Akhtar Ali, Sarfaraz Ahmed, Ali Mohammed Malla, Mahboob Alam, P. S. Pereira Silva, Manuela Ramos Silva, and Dong-Ung Lee. "Synthesis, bioassay, crystal structure and ab initio studies of Erlenmeyer azlactones." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 104 (March 2013): 538–45. http://dx.doi.org/10.1016/j.saa.2012.11.054.

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13

Rostamizadeh, Nader, Alireza Khajeh-Amiri, and Hassan Moghanian. "Microwave-Assisted Erlenmeyer Synthesis of Azlactones Catalyzed by MgO/Al2O3Under Solvent-Free Conditions." Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 46, no. 5 (December 15, 2015): 631–34. http://dx.doi.org/10.1080/15533174.2014.989575.

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14

Yu, Chuanming, Baocheng Zhou, Weike Su, and Zhenyuan Xu. "Erlenmeyer Synthesis for Azlactones Catalyzed by Ytterbium(III) Triflate under Solvent‐Free Conditions." Synthetic Communications 36, no. 22 (November 1, 2006): 3447–53. http://dx.doi.org/10.1080/00397910600941521.

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15

Monk, Keith A., Dusan Sarapa, and Ram S. Mohan. "Bismuth (III) Acetate: A New Catalyst for Preparation of Azlactones via the Erlenmeyer Synthesis." Synthetic Communications 30, no. 17 (September 2000): 3167–70. http://dx.doi.org/10.1080/00397910008086926.

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16

Monk, Keith A., Dusan Sarapa, and Ram S. Mohan. "ChemInform Abstract: Bismuth(III) Acetate: A New Catalyst for Preparation of Azlactones via the Erlenmeyer Synthesis." ChemInform 31, no. 44 (October 31, 2000): no. http://dx.doi.org/10.1002/chin.200044138.

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17

Fadavi, Abdulhamid, and Maaroof Zarei. "One-pot Vilsmeier reagent-mediated multicomponent reaction: A direct synthesis of oxazolones and Erlenmeyer azlactones from carboxylic acids." Comptes Rendus Chimie 21, no. 1 (January 2018): 9–13. http://dx.doi.org/10.1016/j.crci.2017.12.001.

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18

Kiyani, Hamzeh, and Shiva Aslanpour. "Correction to “Synthesis of Erlenmeyer-Plöchl Azlactones Promoted by 5-Sulfosalicylic Acid”: HETEROCYCLES, 2017, 94, 1314, DOI: 10.3987/COM-17-13711." HETEROCYCLES 98, no. 4 (2019): 619. http://dx.doi.org/10.3987/correction-com-17-13711.

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19

Chandrasekhar, Sosale, and Phaneendrasai Karri. "Erlenmeyer Azlactone Synthesis with Aliphatic Aldehydes under Solvent-Free Microwave Conditions." ChemInform 38, no. 17 (April 24, 2007). http://dx.doi.org/10.1002/chin.200717119.

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20

Mogilaiah, K., M. Prashanthi, and Ch Srinivas Reddy. "Solid Support Erlenmeyer Synthesis of Azlactones (III) Using Microwaves." ChemInform 34, no. 52 (December 30, 2003). http://dx.doi.org/10.1002/chin.200352130.

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21

Conway, Philip A., Kevin Devine, and Francesca Paradisi. "ChemInform Abstract: A Simple and Efficient Method for the Synthesis of Erlenmeyer Azlactones." ChemInform 40, no. 33 (August 18, 2009). http://dx.doi.org/10.1002/chin.200933133.

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22

Yu, Chuanming, Baocheng Zhou, Weike Su, and Zhenyuan Xu. "Erlenmeyer Synthesis for Azlactones Catalyzed by Ytterbium(III) Triflate under Solvent-Free Conditions." ChemInform 38, no. 16 (April 17, 2007). http://dx.doi.org/10.1002/chin.200716120.

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23

Anil, Seegehalli M., Muddenahalli S. Sudhanva, Toreshettahally R. Swaroop, Ajjampura C. Vinayaka, Narasimhamurthy Rajeev, Kuppalli R. Kiran, Rangappa Shobith, and Maralinganadoddi P. Sadashiva. "Base Induced Condensation of Malononitrile with Erlenmeyer Azlactones: An Unexpected Synthesis of Multi‐Substituted Δ 2 ‐Pyrrolines and Their Cytotoxicity." Chemistry & Biodiversity 17, no. 5 (April 16, 2020). http://dx.doi.org/10.1002/cbdv.202000014.

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24

Shinde, Rameshwar S., Aditya R. Narnawre, Prashik M. Walke, and Nandkishor N. Karade. "(Diacetoxyiodo)benzene Mediated Oxidative Conversion of Erlenmeyer Azlactones to 2‐Substituted Oxazolines Under Basic Conditions: Synthesis of 4‐Methoxy‐2‐phenyl‐5‐aryl‐4,5‐dihydrooxazole‐4‐carboxylate." ChemistrySelect 8, no. 1 (January 2, 2023). http://dx.doi.org/10.1002/slct.202203899.

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