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Journal articles on the topic 'Erosive Mucosal Lesions'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Heldayani, Iin, and Tenny Setiani Dewi. "Management of toxic epidermal necrolysis with oral involvement with candidiasis in stage III cervical carcinoma patients." Makassar Dental Journal 11, no. 3 (2022): 250–54. http://dx.doi.org/10.35856/mdj.v11i3.636.

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Toxic epidermal necrolysis (TEN) is the most serious cutaneous adverse drug reaction characterized by extensive detachment of epidermis and erosions of oral mucosal. Early diagnosis and proper therapy are an essential for reduction the morbidity and mortality of this disease. This article is aimed to describe the management of TEN with oral involvement accompanied candi-diasis in patient with carcinoma cervix stage III. A 53-year-old female patient with carcinomacervix stage III and diagnosed of TEN was referred to Oral Medicine Clinic with complaint of painful throughout the oral mucosa, on t

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Robinson, Liam, Leande Kotze, and Willie FP Van Heerden. "Giant cell lichenoid stomatitis - An oral medicine case book." South African Dental Journal 75, no. 10 (2020): 550–52. http://dx.doi.org/10.17159/2519-0105/2020/v75no10a3.

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A 53-year-old female patient presented with a two-week history of intermittently painful oral mucosal lesions when eating spicy, salty or sour foods. The patient reported a long-term history of psoriasis treated by topical corticosteroids only. The remainder of the patient's medical history was unremarkable. On intraoral examination, lesions were noted bilaterally in the posterior buccal commissures, appearing as centrally erosive lesions bound by white striations (Figure 1). Additionally, there were areas of desquamative gingivitis in the anterior maxillary gingiva. The clinical suspicion was

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Indre, Madalina-Gabriela, Darius Sampelean, Vlad Taru, et al. "Non-dental oral cavity findings in gastroesophageal reflux disease: a systematic review and meta-analysis." Journal of Mind and Medical Sciences 8, no. 1 (2021): 60–70. http://dx.doi.org/10.22543/7674.81.p6070.

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Gastroesophageal reflux disease (GERD) is known as the most prevalent gastrointestinal disorder in the United States, leading to substantial morbidity, although associated mortality is rare. Based on the appearance of esophageal mucosa on upper endoscopy, GERD is divided into erosive esophagitis (ERD) and nonerosive reflux disease (NERD). Heartburn and acid regurgitation are the typical symptoms of the disease, although some patients may present atypical manifestations such as epigastric pain, nausea, asthma, chronic cough, pharyngitis, laryngitis, sleep disturbances, otitis, and sinusitis. Ot

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Gorai, Maryna A., Larysa F. Kurdysh, Nataliia G. Gadzhula, Olesia V. Kulytska, Halyna M. Poberezhna, and Irina M. Horlenko. "Experience of the Use of Photodynamic Therapy in the Treatment of Chronic Traumatic Lesions of Oral Mucosa." Acta Balneologica 64, no. 5 (2022): 417–21. http://dx.doi.org/10.36740/abal202205107.

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Aim: To evaluate the therapeutic effectiveness of the use of photodynamic therapy in chronic traumatic lesions of oral mucosa. Materials and methods: Clinical examination and treatment of 67 patients aged 18-65 years with erosive-ulcerative lesions of oral mucosa were carried out. Treatment of patients in the main group was performed using photodynamic therapy. Treatment of patients of the control group was carried out according to the standard method. The results of treatment were evaluated by clinical and cytological parameters. Results: In all patients of the main group with chronic traumat

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5

Stéen, Margareta, Regina Diaz, and William E. Faber. "An erosive/ulcerative alimentary disease of undetermined etiology in Swedish moose (AIces alces L.)." Rangifer 13, no. 4 (1993): 149. http://dx.doi.org/10.7557/2.13.3.1106.

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During the years 1985 to 1987, 689 moose (Alces alces L.) collected throughout Sweden were necrop-sied at the National Veterinary Institute in Uppsala, Sweden. Sixty-eight of those investigated had catarrhal to hemorrhagic enteritis, atrophied lymphoid organs, and/or numerous erosive, uclerative, necrotizing lesions of the digestive mucosa. Histopathology of the mucous membranes revealed marked inter- and intracellular oedema, erosions, ulcers and intracytoplasmic inclusion bodies. Neither Bovine Virus Diarrhoea/Mucosal Disease (BVD/MD) or Infectious Bovine Rhinotracheitis (IBR) virus could be

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Krivova, Natalya, Olga Zaeva, Tatiana Misina, and Nikolay Kuvshinov. "Study on Different Mechanisms of Gastric Damage after Oral Administration of Titanium Dioxide Nano- and Microparticles." Key Engineering Materials 683 (February 2016): 447–53. http://dx.doi.org/10.4028/www.scientific.net/kem.683.447.

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The study was performed with male Wistar rats who individually received nano (NPs) or fine (FPs) titanium dioxide (TiO2) particles with an attractive food for 7 days. Two doses of TiO2 NPs (200 and 400 mg/kg) and one dose of TiO2 FPs (200 mg/kg) were used. The macroscopic status of the gastric mucosa as well as the pro-and antioxidant activity of the adherent mucus layer were examined. Our experiments showed that a chronic (7-day) oral administration of TiO2 nanoor microparticles increased the area of erosive lesions and the amount of mucosal hemorrhages with respect to control. However, the d

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Salvi, Ilaria, Ilaria Trave, Riccardo Castelli, Aurora Parodi, and Emanuele Cozzani. "Stevens-Johnson Syndrome and Erythema Multiforme Induced by Imiquimod 5% Cream." Dermatology Practical & Conceptual 15, no. 1 (2025): 4629. https://doi.org/10.5826/dpc.1501a4629.

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Introduction: Topical imiquimod is a safe and effective treatment for actinic keratoses, superficial basal cell carcinomas and anogenital warts. The treatment is commonly associated with local inflammatory reactions, while systemic side effects are rare and generally mild. Only few cases of erythema multiforme and Stevens-Johnson syndrome have been described in association with topical imiquimod application. Objective: We present a review of the existing cases of erythema multiforme and Stevens-Johnson syndrome reported in the literature, analyzing the clinical appearance, the histology and th

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Sklyarov, Ye, A. Chetaykina, M. Mbarki, and O. Kapustinsky. "Prostaglandin E2 in the Blood Serum of Patients with Gastroduodenal Erosive-Ulcerative Lesions with and without Comorbid Hypertension." Lviv clinical bulletin 3-4, no. 39-40 (2023): 21–25. http://dx.doi.org/10.25040/lkv2022.03-04.021.

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Introduction. The combination of erosive-ulcerative lesions (EUI) of the gastroduodenal zone with hypertension (HT) is a common phenomenon and is a modern medicine’s pressing issue. Taking nonsteroidal anti-inflammatory drugs (NSAIDs), including by patients with HT, is accompanied by prostaglandin synthesis suppression due to cyclooxygenase inhibition and results in an arterial pressure increase. Moreover, it should be mentioned that patients with HT have a higher risk of gastroduodenal lesions. The aim of the study. To explore the prostaglandin E2 content in the blood serum of patients with g

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Omoregie, O. F., and M. Okoh. "Oral ulcerative lesions: a review of 55 cases in Benin-City, Nigeria." Nigerian Dental Journal 21, no. 1 (2014): 3–7. http://dx.doi.org/10.61172/ndj.v21i1.62.

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Objective: This study aims to determine the incidence, age, gender, site and treatment outcome of oral ulcerative lesions in Benin City, Nigeria.Method: This is a 3-year retrospective review of all ulcerative oral lesions seen at the Dental Centre, University of Benin Teaching Hospital, Benin City, Nigeria. The medical records, laboratory and histopathology reports of the patients seen between April 2008 and March 2011 the study period were reviewed. All cases of oral ulcerations were selected and patients with erosive mucosa lesions were excluded from this study.Result: A total of 55 (1.3%) c

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Azamatovna, Rasulova Nargiza, and Khabibova Nazira Nasulloyevna. "Oral Mucosal Microbiome as A Factor in The Progression of Leukoplakia in Patients with Carbohydrate Metabolism Disorders." International Journal of Medical Sciences And Clinical Research 5, no. 5 (2025): 43–47. https://doi.org/10.37547/ijmscr/volume05issue05-09.

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Leukoplakia of the oral mucosa in patients with carbohydrate metabolism disorders exhibits a heightened propensity for epithelial dysplasia, with a clinically and molecularly substantiated increase in malignant potential. This progression correlates with shifts in the structure and function of the mucosal microbiome, which acts as a pathophysiological cofactor in epithelial instability. In type 2 diabetes mellitus, metabolic dysregulation contributes to chronic mucosal hypoxia, endothelial dysfunction, and oxidative stress, establishing a microenvironment favorable for dysbiosis. Targeted stud

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Gadda, Rohit B., Rohini Salvi, and Varun Gul Bhatia. "Oral Lichen Planus : A Review." Journal of Contemporary Dentistry 1, no. 2 (2011): 33–36. http://dx.doi.org/10.5005/jcd-1-2-33.

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Abstract Oral lichen planus (OLP) is a chronic mucosal condition commonly encountered in clinical dental practice. Lichen planus is believed to represent an abnormal immune response in which epithelial cells are recognized as foreign, secondary to changes in the antigenicity of the cell surface. It has various oral manifestations, the reticular form being the most common. The erosive and atrophic forms of OLP are less common, yet are most likely to cause symptoms. Topical corticosteroids constitute the mainstay of treatment for symptomatic lesions of OLP. Recalcitrant lesions can be treated wi

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Grewal, Parbeer, and Thomas G. Salopek. "Is Necrolytic Migratory Erythema Due to Glucagonoma a Misnomer? A More Apt Name Might Be Mucosal and Intertriginous Erosive Dermatitis." Journal of Cutaneous Medicine and Surgery 16, no. 2 (2012): 76–82. http://dx.doi.org/10.2310/7750.2011.10134.

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Background: In dermatology, many conditions are given names that ultimately prove to be a misnomer (eg, mycosis fungoides, pyogenic granuloma). For most misnomers, continued use of the inappropriate word(s) rarely results in a delay in diagnosis and/or treatment. An argument can be made that the term necrolytic migratory erythema (NME) due to glucagonoma results in a delay in diagnosis, often with fatal consequences. Objective: We reviewed the literature of the past 30 years concerning the dermatologic and histologic findings of NME in association with glucagonoma. The most striking feature ev

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Laurencin, Cato T., Richard F. Horan, Patrick B. Senatus, Clara B. Wheeler, and Stephen J. Lipson. "Stevens-Johnson-Type Reaction with Vancomycin Treatment." Annals of Pharmacotherapy 26, no. 12 (1992): 1520–21. http://dx.doi.org/10.1177/106002809202601206.

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OBJECTIVE: To report a case of Stevens-Johnson syndrome caused by vancomycin. CASE SUMMARY: Stevens-Johnson syndrome is an acute mucocutaneous process characterized by epidermal and mucosal desquamation. Its pathogenesis is poorly understood. Mortality rates have ranged from 30 to 100 percent. We describe a case of Stevens-Johnson syndrome related to the use of vancomycin in a 71-year-old woman with rheumatoid arthritis receiving treatment for an infected cervical fusion site. Classic “target” lesions distributed throughout the trunk and extremities along with erosive lesions involving the ora

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Fouzia, HAKKOU, ZEMMOURI Yousra, and CHBICHEB Saliha. "Malignant Transformation of Labial Lichen Planus: A Case Report and a Review of the Literature." International Journal of Innovative Research in Medical Science 6, no. 09 (2021): 545–48. http://dx.doi.org/10.23958/ijirms/vol06-i09/1144.

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Oral Lichen Planus (OLP) is a chronic inflammatory dermatosis usually benign that can affect skin, integuments and mucosal membranes presented with various clinical appearances. Typically characterized by the presence of white lace-like lesions, with or without atrophic or erosive areas. Its diagnosis is based on the clinical examination and histological analysis. In most of the cases, the OLP has a benign evolution but malignant transformation may occur justifying the strict surveillance of the disease and effective treatment of relapses. We report the case of a 58-year-old man, without speci

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Bharti, Nisha, Esha Singh, and Shipra Sharda. "Erosive-ulcerative blepharitis in a case of herpes labialis." Indian Journal of Ophthalmology - Case Reports 4, no. 2 (2024): 430–32. http://dx.doi.org/10.4103/ijo.ijo_3148_23.

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A 41-year-old male presented to the outpatient department with complaints of redness and pain in the left lower eyelid for 3 days. Left lower eyelid showed ulcer present laterally on the intermarginal strip with the bare mucosal surface. There was mild edema and conjunctival injection adjacent to the ulcer. He had a history of fever and perioral rashes for last 5 days. Tzanck smear from perioral lesions showed multinucleated giant cells. He was diagnosed with herpes labialis (HL) with ocular involvement. We would like to highlight the presence of erosive-ulcerative blepharitis in association w

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Yang, Ying-Yun, Ke-Min Li, Gui-Fang Xu, et al. "Clinical manifestation, lifestyle, and treatment patterns of chronic erosive gastritis: A multicenter real-world study in China." World Journal of Gastroenterology 30, no. 9 (2024): 1108–20. http://dx.doi.org/10.3748/wjg.v30.i9.1108.

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BACKGROUND Although chronic erosive gastritis (CEG) is common, its clinical characteristics have not been fully elucidated. The lack of consensus regarding its treatment has resulted in varied treatment regimens. AIM To explore the clinical characteristics, treatment patterns, and short-term outcomes in CEG patients in China. METHODS We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and pathology. Patients and treating physicians completed a questionnaire regarding history, endoscopic findings, and treatment plans as well as

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Gomes Jr., Claudio Antonio Rufino, Thais Santana Loução, Glaucia Carpi, and Wilson Roberto Catapani. "A study on the diagnosis of minimal endoscopic lesions in nonerosive reflux esophagitis using computed virtual chromoendoscopy (FICE)." Arquivos de Gastroenterologia 48, no. 3 (2011): 167–70. http://dx.doi.org/10.1590/s0004-28032011000300002.

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CONTEXT: Gastroesophageal reflux disease is very prevalent in the world. Endoscopically it can be classified as nonerosive when there is no mucosal erosive lesion on endoscopy. The presence of endoscopic minimal lesions is included in the Los Angeles classification for reflux disease. Virtual chromoendoscopy Fuji Intelligent Color Enhancement (FICE) is an endoscopic technique that enhances detection of small lesions of the digestive tract. OBJECTIVE: To evaluate whether the use of FICE improves the diagnosis of minimal lesions on endoscopy, and to assess the association of symptoms with minima

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Shuleshova, A. G., L. A. Petrova, and D. V. Danilov. "Endoscopic evaluation of gastric mucosal alterations in patients with chronic heart failure II-III nyha functional class utilizing advanced endoscopic techniques." Experimental and Clinical Gastroenterology, no. 5 (May 18, 2024): 32–42. http://dx.doi.org/10.31146/1682-8658-ecg-225-5-32-42.

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Objective: To assess the alterations of gastric mucosa, its pathomorphological and functional characteristics in patients with complete erosions suffering from chronic heart failure II-III NYHA functional class. Materials and Methods: 185 patients with complete erosions comprised the main group, while the control group consisted of 183 patients with incomplete erosions of the stomach. Patients in both groups had chronic heart failure II-III NYHA functional class. All patients underwent esophagogastroduodenoscopy with white light imaging (WLI), narrow-band imaging (NBI), and ZOOM modes, as well

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Kambil, Srirath Madappally. "Clinico-epidemiological study of childhood lichen planus at a tertiary care centre in South India." International Journal of Research in Dermatology 4, no. 3 (2018): 346. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20182005.

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<p class="abstract"><strong>Background:</strong> Lichen planus (LP) is an autoimmune disorder occurring infrequently in children. LP is mainly seen in adults of both sexes. There are only a few studies on childhood LP in South India.</p><p class="abstract"><strong>Methods:</strong> 52 children under 14 years of age with LP were evaluated. The study was done in the Dermatology outpatient department from April 2016 to March 2018. The various clinical and epidemiological features observed are recorded in the study.<strong></strong></p>&l

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Nobili, C., L. Degrate, R. Caprotti, et al. "Extensive Sclerosing Mesenteritis of the Rectosigmoid Colon Associated with Erosive Colitis." Gastroenterology Research and Practice 2009 (2009): 1–4. http://dx.doi.org/10.1155/2009/176793.

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Sclerosing mesenteritis is a rare, idiopatic, usually benign, inflammatory process of the mesenteric adipose tissue. The most common site of involvement is the small bowel mesentery. We present a case of sclerosing mesenteritis of the rectosigmoid colon as a cause of severe abdominal pain, abdominal obstruction, and ischemic colic mucosal lesions. Contrast enema, colonoscopy, angiography, and CT were the imaging modalities used. A 20 cm diameter, fibrotic mass causing extensive compression of rectosigmoid colon was found at laparotomy. Histological examination showed extended fibrosis, inflamm

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Carvalho, Frédéric A., Nicolas Barnich, Adeline Sivignon, et al. "Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM." Journal of Experimental Medicine 206, no. 10 (2009): 2179–89. http://dx.doi.org/10.1084/jem.20090741.

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Abnormal expression of CEACAM6 is observed at the apical surface of the ileal epithelium in Crohn's disease (CD) patients, and CD ileal lesions are colonized by pathogenic adherent-invasive Escherichia coli (AIEC). We investigated the ability of AIEC reference strain LF82 to colonize the intestinal mucosa and to induce inflammation in CEABAC10 transgenic mice expressing human CEACAMs. AIEC LF82 virulent bacteria, but not nonpathogenic E. coli K-12, were able to persist in the gut of CEABAC10 transgenic mice and to induce severe colitis with reduced survival rate, marked weight loss, increased

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NOSRATZEHI, Tahereh, Abolfazl PAYANDEH, and Atefeh NOSRATZEHI. "The investigation of concomitant dermal and oral lichen planus in patients referred to Zahedan University centres." Journal of Experimental and Clinical Medicine 40, no. 1 (2023): 52–56. http://dx.doi.org/10.52142/omujecm.40.1.11.

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Lichen planus (LP) is a common chronic immunologic inflammatory epidermal and mucocutaneous disorder involving skin, oral mucosa and both sometimes, the main cause of which is still unknown. Due to the importance and its prevalence, this study was carried out in order to assess the association of oral and dermal lesions in patients referring to Dermatology Clinic and Department of Oral and Maxillofacial Diseases, Zahedan Dental School. In this descriptive study, a total of 99 patients with individual involvement of LP in skin or mucosa were selected among 6510 patients referring to Dermatology

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Stepanov, E. V., and V. T. Ivashkin. "Laser Based <sup>13</sup>C-urea Breath Test in Quantitative Assessment of Bacterial Colonization, Severity of Inflammation and Atrophy in Gastric Mucosa." Russian Journal of Gastroenterology, Hepatology, Coloproctology 32, no. 5 (2023): 51–62. http://dx.doi.org/10.22416/1382-4376-2022-32-5-51-62.

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Aim: to compare the results of 13C-UBT with the data of morphological analysis of the gastric and duodenal mucosa obtained during gastroduodenoscopy in gastritis and peptic ulcer. To analyze the dependence of the results of diode laser spectroscopy (DLS) based 13C-UBT on age, nosology, activity and severity of the inflammatory process, the degree of atrophy and metaplasia.Materials and methods. The 13C-UBT DLS was performed in 525 patients before the start of eradication therapy and in 196 patients 10–12 weeks after its completion. The breath test was carried out according to a standard protoc

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Botrugno, Rachel, Bijaya Rajlawat, Daniel Finn, and Paul Devakar Yesudian. "P099 Use of roflumilast in erosive oral inflammatory conditions." British Journal of Dermatology 191, Supplement_1 (2024): i62—i63. http://dx.doi.org/10.1093/bjd/ljae090.126.

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Abstract Roflumilast is a phosphodiesterase type 4 (PDE4) inhibitor commonly used in respiratory medicine to manage chronic obstructive lung disease. Recently, there have been case reports of its effectiveness in oral mucosal conditions. We review five patients with different erosive mucosal lesions who responded to this medication. All patients were commenced on 250 μg daily, increasing to 500 μg if indicated. Case 1 is a 57-year-old woman who presented to the dermatology/oral medicine (DOM) clinic with long-standing recurrent aphthous stomatitis from her late teens. Treatment with colchicine

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Toader, Mihaela Paula, Madalina Mocanu, Stefan Toader, Roxana Irina Iancu, and Tatiana Taranu. "Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus." Revista de Chimie 71, no. 4 (2020): 438–45. http://dx.doi.org/10.37358/rc.20.4.8085.

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Tacrolimus, a macrolide with immunosuppressive properties through the inhibition of T-lymphocyte activation, was approved as a second line topical treatment for atopic dermatitis, but has been largely used with beneficial effects in other dermatological conditions that involve a disregulation of the cellular immune response. Oral lichen planus is a T-cell�mediated autoimmune disease in which autocytotoxic CD8+ T cells trigger apoptosis of oral epithelial cells. Our study aimed to analyze the clinical efficacy of tacrolimus 0.03% and 0.1% in orabase as monotherapy on oral erosive lesions of lic

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Vshivkov, V. A., Tamara V. Polivanova, E. V. Kasparov, O. V. Peretyatko, and T. N. Akhmetshin. "THE STATE OF THE MUCOSA OF THE GASTRODUODENAL ZONE IN SCHOOLCHILDREN RESIDING IN AREAS WITH A HIGH PREVALENCE RATE OF GASTRIC CANCER." Russian Pediatric Journal 21, no. 1 (2019): 26–30. http://dx.doi.org/10.18821/1560-9561-2018-21-1-26-30.

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The aim is to determine the severity of mucosal lesions of gastroduodenal zone, colonization of Helicobacter pylori and their association with intestinal complaints by school students of the aboriginal and alien population of the Republic of Tuva. Materials and methods. Over 2017 we had observed 471 schoolchildren aged 7-17 years from the aboriginal (Tuva-Mongoloids) and aliens (Caucasians) population of the Republic of Tuva. We created represented groups (69 aboriginal and 34 alien inhabitants) and executed esophagogastroduodenoscopy with the biopsy from the antrum and body of stomach taken f

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Nesa, Ni Nyoman Metriani, Andy Darma, Alpha Fardah Athiyyah, IGM Reza Ranuh, Khadijah Rizky Sumitro, and Subijanto Marto Sudarmo. "Brunner’s gland hyperplasia as a cause of gastric outlet obstruction in a seven year old boy." Bali Medical Journal 12, no. 2 (2023): 1608–11. http://dx.doi.org/10.15562/bmj.v12i2.4484.

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Link of Video Abstract: https://youtu.be/9-ynkRS_wo8 Introduction: Brunner’s glands are acinotubular glands which are located mostly in the deep mucosal or submocosal layers of the proximal duodenum. Hyperplasia of these glands is reported in almost 1 in 50 upper gastrointestinal endoscopies and accounts for approximately 5 to 10 percent of all benign duodenal tumors. Brunner’s gland hyperplasia is usually asymptomatic. It can take form of polypoid or mass lesions and precipitate pyloric obstruction, gastrointestinal hemorrhage, and intussusception in children. Due to its rarity in pediatric p

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Fadieienko, G. D., and S. V. Gridineva. "Cytoprotectant Doctovit: perspectives of the use at acid-dependent gastroduodenal diseases." Modern Gastroenterology, no. 3 (June 29, 2023): 43–48. http://dx.doi.org/10.30978/mg-2023-3-43.

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The paper presents analysis of publications devoted to the use of cytoprotectant Doctovit at acid‑dependent gastroduodenal diseases and prospects of its use at inflammatory and erosive injuries of the esophagus, stomach and duodenum. A pathogenetic substantiation of the expediency of using the Doctovit (a complex of vitamins U (methylmethionine) and B5 (dexpanthenol)) is presented for cases of erosive and ulcerative (Helicobacter pylori‑associated) gastroduodenal lesions and at NSAID‑gastropathy, as well as at preservation of inflammatory changes in the gastric mucosa after antihelicobacter th

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Sharma, Shubham, Nagaraju Kamarthi, Sumit Goel, Sangeeta Malik, Swati Gupta, and Abhinav Sharma. "Comparative evaluation of autologous platelet rich plasma and triamcinolone acetonide injection in the management of erosive lichen planus and oral submucous fibrosis: a clinical study." International Journal of Basic & Clinical Pharmacology 12, no. 3 (2023): 439–45. http://dx.doi.org/10.18203/2319-2003.ijbcp20231125.

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Background: It is need of an hour to establish an effective and efficient treatment modality for OLP and OSMF with lesser or no adverse effects. Platelet rich plasma can be used in mucosal lesions as it has a high concentration of various growth factors and anti-inflammatory properties. It could be a better novel substitute to the corticosteroid without any side effects. The present study is an effort to evaluate the therapeutic effects of intralesional injection of PRP in oral erosive lichen planus and OSMF compared to intralesional corticosteroids in the same patient. Methods: It was a rando

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Paredes, Sergio D., Jorge Hernández-Cortés, Farzin Falahat, Lisa Rancan, Javier Arias-Díaz, and Elena Vara. "Protective Effect of Pentoxifylline on the Development of Acute Gastric Mucosal Injury in a Model of LPS-Induced Sepsis." Antioxidants 13, no. 12 (2024): 1481. https://doi.org/10.3390/antiox13121481.

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Alterations in the gastric mucosal barrier, one of whose fundamental components is phosphatidylcholine (PC), may play an important role in the pathophysiology of erosive gastritis secondary to sepsis. Pentoxifylline (PTX) has been shown to reduce tissue damage in various experimental models of sepsis. The aim of this study was to investigate the effect of PTX on gastric mucosa PC synthesis, leukocyte infiltration, arachidonic acid-related metabolites, inflammation, oxidative stress, NO, CO, and somatostatin in a rat model of LPS-induced sepsis. Rats were administered LPS (10 mg/kg b.w.) intrap

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AZIZOVA, Gavhar Mahmudkhanovna, Sardor Khamdamovich IBRAGIMOV, Anvarbek Shamkhatovich ARIFJANOV, and Ravshan Aliyevich IBADOV. "A proposed new method of hemostasis for erosive-hemorrhagic complications of the trachea and bronchi." Journal of Life Science and Biomedicine 13 (June 25, 2023): 42–47. http://dx.doi.org/10.54203/jlsb.2023.6.

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Ventilator-associated complications are the most frequent ones that prevent the recovery of intensive care patients. This study aimed to evaluate the effectiveness of the endoscopic treatment of acute hemorrhagic lesions of the tracheobronchial tree in patients with ventilator-associated tracheobronchitis. A total of 5 patients (22.4±3.3 mean age, 18 to 36 years) with prolonged mechanical ventilation (>48 hours) in the resuscitation and intensive care unit were monitored. The diagnosis of ventilator-associated tracheobronchitis was established on the basis of clinical signs, radiological an

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Zargham, Hanieh, Stephanie Ghazal, Kevin Watters, and Khue Huu Nguyen. "A case of toxic epidermal necrosis–like cutaneous eruption as the first manifestation and clue to the diagnosis of systemic lupus erythematosus: A case report." SAGE Open Medical Case Reports 8 (January 2020): 2050313X2094042. http://dx.doi.org/10.1177/2050313x20940420.

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We present a rare case of a 61-year-old woman presenting with a widespread erosive eruption on her torso and extremities. Although the lesions were histologically compatible with toxic epidermal necrolysis, clinically the patient was hemodynamically stable, had no mucosal involvement and had no relevant medical history or potentially incriminating medications. Further investigations uncovered a new diagnosis of systemic lupus erythematosus, with this toxic epidermal necrolysis–like eruption being the first presentation of the disease. This case highlights the importance of broadening the diffe

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Rezuș, Elena, Maria Alexandra Burlui, Anca Cardoneanu, et al. "Multicentric Reticulohistiocytosis Exhibiting Positive HLA-B*07 and HLA-B*08: A Case Report." Medicina 56, no. 9 (2020): 456. http://dx.doi.org/10.3390/medicina56090456.

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Multicentric reticulohistiocytosis (MRH) is a rare cause of destructive inflammatory arthritis involving both small, as well as larger joints. We report the case of a 40-year-old Caucasian female with a family history of neoplasia who was referred to our service witha two-month history of inflammatory joint pain. On examination, the patient had inflammatory arthritis, mainly involving the peripheral joints, sacroiliac joint pain, and numerous papulonodular mucocutaneous lesions, including periungual “coral beads”. Imaging tests revealed erosive arthritis with synovitis and tenosynovitis, sacro

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Pranadwista, Zulfa Fidi, Etis Duhita Rahayuningtyas, and Irna Sufiawati. "Addressing Challenges in Diagnosis, Differential Diagnosis, and Treatment of Pemphigus: A Case Series." Diagnostics 13, no. 24 (2023): 3633. http://dx.doi.org/10.3390/diagnostics13243633.

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Pemphigus is a rare autoimmune disease characterized by skin blisters and erosions, with or without mucosal involvement. The clinical presentation of pemphigus can resemble other bullous diseases, leading to challenges in diagnosis. This report aims to address the challenges in diagnosing and treating oral pemphigus. Three patients, ranging in age from 26 to 55 years, complained of a sore throat and mouth canker sores. Extra-oral examination revealed dry lips in case 1, while serosanguinolenta crust on the lip that bled easily was found in case 2. Intra-oral examinations in all cases showed mu

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MacLaren, Robert. "A Review of Stress Ulcer Prophylaxis." Journal of Pharmacy Practice 15, no. 2 (2002): 147–57. http://dx.doi.org/10.1106/ead9-p8rx-d7j7.

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Stress-related mucosal damage (SRMD) is an erosive process of the gastroduodenum that occurs frequently in critically ill patients. Symptomatic lesions may range from overt bleeding (by hematemesis, melena, bloody or coffee ground aspirates, or hematochezia) to clinically significant hemorrhage (hypotension, tachycardia, or acute anemia requiring transfusion). SRMD is caused by mucosal ischemia that produces an imbalance between injurious factors and the protective mechanisms. Common patient risk factors include mechanical ventilation, coagulopathy, shock, hepatic dysfunction, renal dysfunctio

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Zainullin, T. A., E. V. Ivanova, D. A. Moiseev, et al. "Features of differential diagnosis of lichen planus and lichenoid reaction of the oral cavity: histopathological analysis." Clinical Dentistry (Russia) 28, no. 1 (2025): 18–24. https://doi.org/10.37988/1811-153x_2025_1_18.

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Lichen planus is a chronic autoimmune skin-mucosal disease that often affects the oral cavity and can affect the esophagus, the mucous membrane of the genitals, the skin and its appendages. Lichenoid reactions are considered as lesions clinically similar to lichen planus erythematosus, but differing in pathogenesis, etiology and, consequently, treatment approaches. The main provoking factors of lichenoid reactions are medicines and dental materials. The aim of the study was to identify histopathological differences between lichen planus erythematosus and lichenoid reactions of the oral cavity

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Robles-Medranda, Carlos, Manuel Valero, Miguel Soria-Alcívar, et al. "Detection of minimal mucosal esophageal lesions in non-erosive gastroesophageal reflux disease using optical enhancement plus optical magnification." Endoscopy International Open 07, no. 08 (2019): E979—E986. http://dx.doi.org/10.1055/a-0953-1844.

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Abstract Background and study aims The aim of this study was to evaluate the diagnostic yield of endoscopy using optical enhancement (OE system) with optical magnification to predict reflux in non-erosive reflux disease (NERD) patients. Patients and methods A prospective, non-randomized, single-blind study was performed from September 2015 to January 2016. Participants suffered from gastroesophageal reflux disease (GERD) symptoms and were assigned to the NERD group or the non-reflux disease control group based on endoscopic findings and a 24-hour pH-impedance-monitoring test. Endoscopy using t

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Martin, Micheal D., and Mark Drangsholt. "Oral Lichenoid Lesions Associated With Dental Amalgam Restorations: A 60-Year-Old Woman With a 7-Year History of Painful, Erosive Mucosal Lesions." Journal of Evidence Based Dental Practice 5, no. 3 (2005): 131–38. http://dx.doi.org/10.1016/j.jebdp.2005.06.021.

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Lunitsyna, Yuliya, Kseniia Ziablitskaia, Olga Bondarenko, Larisa Chudova, and Ella Shteinke. "METHODS OF DIAGNOSIS AND TREATMENT OF ORAL MUCOSAL LEUKOPLAKIA (LITERATURE REVIEW)." Actual problems in dentistry 18, no. 3 (2022): 49–56. http://dx.doi.org/10.18481/2077-7566-2022-18-3-49-56.

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Subject. The high prevalence of oral mucosal leukoplakia, its often recurrent course and the possibility of malignancy makes the problem of finding effective methods of diagnosis and treatment of this pathology urgent. Many methods of acting lesions have been proposed, but individual studies cannot demonstrate evidence of the advantages of one treatment method over another. Objectives. On the basis of modern literature to determine effective methods of diagnosis and treatment of various forms of leukoplakia. Methodology. The information bases are analyzed: PubMed, Elibrary, GoogleS

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Gorouhi, Farzam, Parastoo Davari, and Nasim Fazel. "Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis." Scientific World Journal 2014 (2014): 1–22. http://dx.doi.org/10.1155/2014/742826.

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Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can

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Traserra, Sara, Héctor Cuerda, Adriana Vallejo, Sergi Segarra, Roger Sabata, and Marcel Jimenez. "Gastroprotective Effects of Oral Glycosaminoglycans with Sodium Alginate in an Indomethacin-Induced Gastric Injury Model in Rats." Veterinary Sciences 10, no. 12 (2023): 667. http://dx.doi.org/10.3390/vetsci10120667.

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The gastrointestinal (GI) mucosal barrier is often exposed to inflammatory and erosive insults, resulting in gastric lesions. Glycosaminoglycans (GAGs), such as hyaluronic acid (HA), chondroitin sulfate (CS), and N-acetylglucosamine (NAG) have shown potential beneficial effects as GI protectants. This study aimed to evaluate the gastroprotective effects of oral GAGs in rats with indomethacin-induced GI lesions. Forty-five Sprague–Dawley rats (8–9 weeks-old, 228 ± 7 g) were included in the study, divided into five study groups, and given, administered orally, either sucralfate (positive control

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Shreya, K., and Dinesh Asati. "DermatopathologyOral presentationsDP01 A single-centre cross-sectional observational study on dermoscopy of genital mucosal disorders and histopathological correlation in a tertiary care centre." British Journal of Dermatology 191, Supplement_1 (2024): i107. http://dx.doi.org/10.1093/bjd/ljae090.223.

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Abstract Dermoscopy of mucosa is known as mucoscopy. Mucoscopy can aid in delineating minute aspects of mucosal lesions and will help to differentiate similar-looking lesions. The aim of this study is to describe mucoscopic features and correlate them with histopathology in various genital mucosal diseases. The study was conducted at a tertiary care centre between October 2020 to April 2022 after Institutional Human Ethics Committee approval. The sampling technique was based on the convenience purposive method. Any patients with mucosal disease receiving treatment or planning to receive treatm

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Nitro, Letizia, Carlotta Pipolo, Paolo Castellarin, et al. "Implementation of Routine Endoscopy with Narrow Band Imaging in the Evaluation of Oral and Upper Airways Lesions in Oral Chronic Graft-Versus-Host Disease: A Preliminary Study." Journal of Personalized Medicine 12, no. 10 (2022): 1628. http://dx.doi.org/10.3390/jpm12101628.

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(1) Background: The aim of our study is to investigate the main oral lesion patterns in patients with oral graft-versus-host disease and to describe and validate the use of endoscopy enhanced with narrow-band imaging (NBI) as a personalized, reliable and user-friendly tool for the early detection of oral potentially diseases. (2) Methods: We retrospectively evaluated the medical records of 20 patients with chronic GVHD and with oral manifestations, who were referred to our “Interdisciplinary Center for Oropharyngeal Pathology (CIPO)” from January 2017 to July 2022. (3) Results: Data on GVHD, o

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Nadiia, Kononenko, Mirzaliev Mirzachan, and Chikitkina Valentina. "Influence of dry extract of brassica olearacea on the morphological structure of the gastric mucosa of rats during an experimental ulcer caused by alcohol-prednisolone mixture." ScienceRise: Pharmaceutical Science, no. 3(19) (June 28, 2019): 30–41. https://doi.org/10.15587/2519-4852.2019.173455.

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<strong>Aim</strong> – study of the effect of cabbage dry extract on the morphological state of the gastric mucosa of rats on the background of an experimental alcohol-prednisolone ulcerative lesion. <strong>Materials and methods.</strong> Ulcerative lesions of the gastric mucosa of nonlinear white rats were reproduced by intragastric administration of a mixture of 80% ethanol and prednisolone 20 mg/kg at the rate of 0.6 ml per 100 g of body weight. Dry extract of cabbage in doses of 30, 40, 50 and 60 mg/kg and the reference drug Altan at a dose of 1 mg/kg was administered intr

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Matsushima, Yoshiaki, Masako Kitano, Daisuke Hayashi, et al. "A Case of IgG and IgA Anti-Laminin-332 Antibody-Positive Mucous Membrane Pemphigoid with IgG and IgA Anti-Envoplakin and Anti-Periplakin Antibodies." Dermatopathology 9, no. 3 (2022): 287–91. http://dx.doi.org/10.3390/dermatopathology9030034.

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A 76-year-old Japanese man presented with a 6-year history of a sore throat. He was treated at several clinics without any improvement before being referred to us. Physical examination revealed widespread erosions and ulcers from the palate to the larynx. Approximately 25 × 15 mm in size, erosive lesions were present on the retroauricular regions, forearms, and glans penis. Pseudomembranous conjunctivitis was also observed. The skin biopsy revealed a partial cleft formation below the epidermis, suggesting subepidermal bullous disease. Immuno-serological tests were negative for anti-desmoglein

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Khader, Fathima Juhaina M. Abdul, M. Arhoul Rennies, R. S. Atchayavarshini, B. Deepasree, and G. Georglin Heavenlia. "Overlapping Stevens-Johnson Syndrome and Staphylococcal Scalded Skin Syndrome in a Three-Year-Old Child: A Rare Pediatric Dermatologic Emergency." International Journal of Medical and Pharmaceutical Case Reports 18, no. 3 (2025): 63–67. https://doi.org/10.9734/ijmpcr/2025/v18i3438.

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Aims: To report a rare pediatric case presenting with overlapping Stevens-Johnson Syndrome and Staphylococcal Scalded Skin Syndrome complicated by impetigo in a three -year-old child, highlighting diagnostic and therapeutic challenges. Presentation of Case: A three-year-old female child presented to the emergency department with fever, perioral vesicles, crusting, and perioral pain. The symptoms began after an upper respiratory tract infection and treatment with amoxicillin. Over a period of four days, the child developed worsening vesiculobullous lesions with perioral crusting and mucosal inv

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Ouédraogo, Muriel Sidnoma, Djimtibaye Djounitanan, Nomtondo Amina Ouédraogo, et al. "Epidemiological, clinical and therapeutic aspects of dermatitis herpetiformis at Yalgado Ouédraogo University Hospital Centre, Burkina Faso." Our Dermatology Online 14, no. 3 (2023): 259–62. http://dx.doi.org/10.7241/ourd.20233.4.

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Background: Dermatitis herpetiformis is a rare autoimmune bullous dermatosis that predominantly affects Caucasians, adults or children, with a sex ratio of 1.8. Materials and Methods: The aim of this study was to document the clinical and epidemiological profiles of dermatitis herpetiformis and to detail its treatment in a hospital setting in order to increase our knowledge about this disease in our context and so to improve its management. We conducted a retrospective, cross-sectional study of the records of all patients seen in consultation or hospitalized at the dermatology department of Ya

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Shin, Heung Mook. "Anti-oxidative Herbs and Indomethacin-Induced Rat Gastric Mucosal Lesions: Protection by GamiHyangsa-Yukgunja." American Journal of Chinese Medicine 29, no. 01 (2001): 101–9. http://dx.doi.org/10.1142/s0192415x01000113.

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This study investigates the protective effects of GamiHyangsa-Yukgunja (GHY, a popular herbal medicine formula) on indomethacin-induced gastric mucosal lesions and morphological change in rats. Subcutaneous injection of indomethacin (25 mg/kg) produced the following gastric morphological alterations; mucosa hermorrhagic infarct, mucosa cell necrosis, leukocyte infiltration, mucosa hemorrhagic erosion, and gastric pit disappearance. Tissue damages were accompanied by increased oxidative stress, lipid peroxidation, and decreases in superoxide dismutase (SOD), and catalase (CAT) activities, and g

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Poliantsev, A. A., D. V. Frolov, A. M. Linchenko, et al. "Prevention of gastrointestinal bleeding in patients operated on the arteries of the lower extremities for critical ischemia." Experimental and Clinical Gastroenterology, no. 11 (January 23, 2023): 160–70. http://dx.doi.org/10.31146/1682-8658-ecg-207-11-160-170.

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The purpose of the study. To determine the frequency of occurrence and prevention measures of erosive and ulcerative lesions of the proximal gastrointestinal tract in patients operated for critical ischemia with a diagnosis of obliterating atherosclerosis of the arteries of the lower extremities. Materials and methods. The examination included patients with lower limb ischemia - III-IV stage of ischemia according to the Fontaine-Pokrovsky classification. The patients were divided into 2 groups: the control group, where treatment was carried out according to the recommendations: HP diagnosis (e

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Ahmed, Shaikh, Md Rubayet Alam Prodhan, Rifat Rezwana, Jahan Sadia Afroz, Mottakin Ahmad, and Md Rakibul Hassan Khan. "Comparison between uses of topical tacrolimus and triamcinolone ointment for the treatment of oral lichen planus." Update Dental College Journal 8, no. 1 (2018): 17–21. http://dx.doi.org/10.3329/updcj.v8i1.38407.

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Background: Lichen planus is a chronic mucocutaneous disease with primary or secondary involve- ment of the oral mucosa. In particular in case of erosive lichen planus most of the patients experience no long term symptoms relief of conventional topical treatment such as corticosteroid ointment. Topical tacrolimus applications to mucosal lesions seem to be an alternative treatment approach.Objective: The aim of this study was to compare the efficacy of topical tacrolimus ointment with that of triamcinolone acetonide ointment on patients suffering from oral lichen planus.Study design: This was a

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