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Journal articles on the topic 'Erytem evaluation'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Kausar, Rizwana, and Naveed Akhtar. "EVALUATION OF DEPEGMENTING AND ANTIERYTHEMIC EFFECTS OF COSMETIC EMULGELS CONTAINING RASPBERRY FRUIT EXTRACT ON HUMAN CHEEK SKIN." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 1 (December 31, 2016): 236. http://dx.doi.org/10.22159/ijpps.2017v9i1.15123.

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<p><strong>Objective: </strong>This research work was performed to discover the efficacy of newly formulated topical formulation (o/w) emulgel of Raspberry fruit extract against its base taken as a control on skin erythema and skin melanin.</p><p><strong>Methods: </strong>Concentrated Raspberry fruit<em> </em>extract was prepared by macerating fresh fruit in aqueous methanol under room temperature. This extract was then entrapped in the inner oily phase of o/w emulgel. Newly formulated, formerly evaluated base (without extract) and a formulation containing 4% concentrated extract of Raspberry were applied to cheeks of 13 healthy female human volunteers for a period of 12 w. Skin erythma and melanin were measured after every two weeks to evaluate any effect produced by this topical formulation.</p><p><strong>Results: </strong>Base showed insignificant (p≥0.05) while formulation showed a significant decrease in skin erythma. Skin melanin content was insignificantly decreased by base but significantly decreased by the formulation. The newly developed cosmetic emulgel of Raspberry fruit extract showed its effects without causing any irritation and was found to be suitable and safe dermatological formulation.</p><p><strong>Conclusion: </strong>Formulation was successfully evaluated for its dermatological effects. It was found to be a useful, harmless and cost effective skin whitening treatment derived from natural sources.</p>

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AKDIŞ, A. C., K. KILIÇTURGAY, S. HELVACI, R. MISTIK, and B. ORAL. "Immunological evaluation of erythema nodosum in tularaemia." British Journal of Dermatology 129, no. 3 (September 1993): 275–79. http://dx.doi.org/10.1111/j.1365-2133.1993.tb11846.x.

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3

Marshall, John K., and E. Jan Irvine. "Successful Therapy of Refractory Erythema Nodosum Associated with Crohn's Disease Using Potassium Iodide." Canadian Journal of Gastroenterology 11, no. 6 (1997): 501–2. http://dx.doi.org/10.1155/1997/434989.

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Erythema nodosum is a common extraintestinal manifestation of Crohn's disease. While mild skin involvement often responds to conservative management, severe or refractory cases may require systemic corticosteroid or immunosuppressive therapy. This report describes successful treatment of severe, refractory erythema nodosum associated with Crohn's colitis using oral potassium iodide. While the mechanism of action of this agent is poorly understood, it appears to be an effective and nontoxic therapy for Crohn's-related erythema nodosum and warrants further evaluation in a placebo controlled trial.

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Cugmas, Blaž, Daira Viškere, Eva Štruc, and Thierry Olivry. "Evaluation of Erythema Severity in Dermatoscopic Images of Canine Skin: Erythema Index Assessment and Image Sampling Reliability." Sensors 21, no. 4 (February 11, 2021): 1285. http://dx.doi.org/10.3390/s21041285.

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The regular monitoring of erythema, one of the most important skin lesions in atopic (allergic) dogs, is essential for successful anti-allergic therapy. The smartphone-based dermatoscopy enables a convenient way to acquire quality images of erythematous skin. However, the image sampling to evaluate erythema severity is still done manually, introducing result variability. In this study, we investigated the correlation between the most popular erythema indices (EIs) and dermatologists’ erythema perception, and we measured intra- and inter-rater variability of the currently-used manual image-sampling methods (ISMs). We showed that the EIBRG, based on all three RGB (red, green, and blue) channels, performed the best with an average Spearman coefficient of 0.75 and a typical absolute disagreement of less than 14% with the erythema assessed by clinicians. On the other hand, two image-sampling methods, based on either selecting specific pixels or small skin areas, performed similarly well. They achieved high intra- and inter-rater reliability with the intraclass correlation coefficient (ICC) and Krippendorff’s alpha well above 0.90. These results indicated that smartphone-based dermatoscopy could be a convenient and precise way to evaluate skin erythema severity. However, better outlined, or even automated ISMs, are likely to improve the intra- and inter-rater reliability in severe erythematous cases.

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Stoleru, Gianna, Lauren George, Raymond K. Cross, and Uni Wong. "An Unusual Presentation of Baker’s Cyst Rupture in an Inflammatory Bowel Disease Patient." Case Reports in Medicine 2020 (January 8, 2020): 1–3. http://dx.doi.org/10.1155/2020/3149058.

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When evaluating a patient with acute onset unilateral leg pain and concurrent inflammatory bowel disease (IBD), keeping a broad differential diagnosis will allow for prompt diagnosis and management. The patient described in this case report is a 32-year-old male with inflammatory ileocolonic Crohn’s disease (CD) status after ileocecectomy with perianal involvement and known Type 1 arthropathy. He presented with a three-day history of unilateral leg swelling and tenderness. Initial evaluation focused on possible thrombosis given the development of erythema and systemic symptoms. Final diagnosis was ruptured Baker’s (popliteal) cyst. This pathology is not well described in existing literature, but should be considered in IBD patients given their chronic inflammatory state and common associated intra-articular pathology.

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6

Inui, Shigeki, Hitoshi Ikegawa, and Satoshi Itami. "Dermoscopic evaluation of erythema associated with pressure ulcers." International Journal of Dermatology 50, no. 8 (July 22, 2011): 945–47. http://dx.doi.org/10.1111/j.1365-4632.2010.04784.x.

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7

Greenwood, Jason D., Nathaniel Nielsen, and Nathaniel E. Miller. "Patient on Immunomodulatory Therapy Experiencing Joint Pain and Skin Lesions: A Case Report." Journal of Primary Care & Community Health 12 (January 2021): 215013272110058. http://dx.doi.org/10.1177/21501327211005894.

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A woman in her late fifties was admitted to the Family Medicine Inpatient Service directly from Rheumatology clinic for polyarticular pain and erythema with concern for infection. She was taking immunosuppressant medications for a history of multiple autoimmune diseases. Examination showed increasing erythema and tenderness on the upper and lower extremity joints. Histologic evaluation, surgical evaluation, and cultures were consistent with mycobacterium haemophilum infection. Mycobacterium haemophilum is an uncommon opportunistic infection that usually affects immunocompromised patients. The patient was treated with a multi-drug antibiotic regimen for several months due to drug resistance. Although this opportunistic infection is not common it should be considered in the differential of immunocompromised patients with skin and articular symptoms. Treatment outcomes are usually favorable if it caught earlier in the course.

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8

Bulgakova, A. I., Z. R. Hismatullina, and M. V. Zatcepina. "Optimisation of diagnostics and complex treatment of multi-form exudative erythema of cavity mucosa." Stomatology for All / International Dental review, no. 2020 1 (90) (March 2020): 4–8. http://dx.doi.org/10.35556/idr-2020-1(90)4-8.

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The article presents the results of studies of complex treatment oral mucosa of patients with Erythema multiforme in detail of the developed algorithm. Subjective and objective criteria of oral mucosa state and local humoral immunity are proposed for evaluation of therapy effectiveness in patients with multi-form exudative erythema in the main and comparison group. A comparative characteristic of dental indicators of quality of life was made according to the questionnaire OHIP-14-RU in both groups.

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Masthan, KMK, E. Vinesh, M. Sathish Kumar, S. Marytresa Jeyapriya, Aravindha Babu, and Meera Thinakaran. "A Clinicopathologic Study of Oral Changes in Gastroesophageal Reflux Disease, Gastritis, and Ulcerative Colitis." Journal of Contemporary Dental Practice 17, no. 11 (2016): 943–47. http://dx.doi.org/10.5005/jp-journals-10024-1959.

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ABSTRACT Objectives The aim and objectives of this study are to identify oral changes in certain gastrointestinal (GI) diseases, namely gastroesophageal reflux disease (GERD), ulcerative colitis, gastritis, and to evaluate these oral symptoms as indicators for assessing GI disorders. Materials and methods In this study, the oral manifestations of various GI disorders were assessed in a varying age group of 250 patients in Government Stanley Medical College and Hospital, Chennai. Out of 250 patients, 142 were affected by GERD, 99 were affected by gastritis, and 9 patients were affected by ulcerative colitis. Of these patients, 177 were males and 73 were females. Results Evaluation of patients with gastritis revealed that 66.7% affected with gingivitis, 19.2% with dental erosion on the palatal and lingual aspects of maxillary and mandibular teeth predominantly in the anterior region, 10.1% with periodontitis, 2% with gingival erythema. Among the patients with GERD, 44% of the cases showed dental erosion, 25.5% periodontitis, 9.9% gingivitis, 5.7% gingival erythema, 2.8% palatal erythema, 2.1% gingival ulcers, glossitis 2%, 1.4% floor of the mouth erythema, and 0.7% erythema of the tongue. Patients with ulcerative colitis showed 44.4% of gingival erythema, 33.3% of dental erosions, and 22.2% of gingival ulcers and periodontitis. Conclusion In our study of 250 patients, oral manifestations were observed in 88% of the patients. Both soft tissue and hard tissue changes were evident. There was a high correlation between various GI disease and dental erosion, erythema at various sites of the oral cavity, oral ulcers, gingivitis, periodontitis, and glossitis. Careful evaluation of oral cavity may unveil many GI disorders and help the patient by providing early diagnosis, which further facilitates the prognosis. How to cite this article Vinesh E, Masthan KMK, Kumar MS, Jeyapriya SM, Babu A, Thinakaran M. A Clinicopathologic Study of Oral Changes in Gastroesophageal Reflux Disease, Gastritis, and Ulcerative Colitis. J Contemp Dent Pract 2016;17(11):943-947.

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Dykes, P. J., D. R. Black, M. York, A. D. Dickens, and R. Marks. "A stepwise procedure for evaluating irritant materials in normal volunteer subjects." Human & Experimental Toxicology 14, no. 2 (February 1995): 204–11. http://dx.doi.org/10.1177/096032719501400209.

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1 The cutaneous response to a known irritant has been assessed in human volunteer subjects using both clini cal scoring and two non-invasive instrumental meth ods ; erythema measurement using an erythema meter and capillary blood flow using a laser Doppler device. 2 Aqueous solutions (0.5% and 1%) of sodium hydroxide were applied to back skin for 3, 15 and 60 min with assessments immediately after removal and at 1, 24 and 48 hours. 3 Increased erythema was seen with increasing duration of exposure and an increase was also seen at 1 h, 24 h and 48 h after removal of the patch. The results obtained with the erythema meter paralleled the clini cal erythema scores. However, the laser Doppler device showed the greatest changes immediately after removal of the patch with subsequent readings show ing a gradual decrease. 4 Statistical analysis of the data has been carried out to determine the accuracy and precision of the assess ment procedures and to determine the minimum test panel size for detecting irritant reactions. 5 Comparison between back and forearm skin indicated a greater sensitivity to sodium hydroxide on the back. 6 The results of this study define an ethical approach to testing irritant materials in human subjects and pro vide the basis for the development of a classification system for cutaneous irritants.

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Wormser, G. P., D. Liveris, J. Nowakowski, R. B. Nadelman, D. Holmgren, S. Bittker, D. Cooper, G. Wang, and I. Schwartz. "Microbiologic Evaluation of Patients from Missouri with Erythema Migrans." Clinical Infectious Diseases 40, no. 3 (February 1, 2005): 423–28. http://dx.doi.org/10.1086/427289.

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12

Freeman, Hugh J. "Erythema Nodosum and Pyoderma Gangrenosum in 50 Patients with Crohn’s Disease." Canadian Journal of Gastroenterology 19, no. 10 (2005): 603–6. http://dx.doi.org/10.1155/2005/323914.

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Erythema nodosum and pyoderma gangrenosum may occur in Crohn's disease. In the present evaluation of consecutive patients with Crohn's disease spanning more than two decades, erythema nodosum was seen in 45 patients and pyoderma gangrenosum was seen in seven patients. Forty-one of 566 women (7.2%) and nine of 449 men (2.0%) were affected. Of these, 45 (4.4%) had erythema nodosum and seven (0.7%) had pyoderma gangrenosum, including two (0.2%) with both dermatological disorders at different times during their clinical courses. Recurrent erythema nodosum was also detected in nine patients (20%) including eight women, while recurrent pyoderma gangrenosum was seen in two patients (28.6%). There was an age-dependent effect on the appearance of erythema nodosum in women, with the highest percentages seen in those younger than 20 years of age. Detection rates for erythema nodosum in women only approached the low mens' rates in Crohn's disease at older than 40 years of age. Most patients with these dermatological disorders had colonic disease with or without ileal involvement as well as complex disease, usually with penetrating complications. The present study documents a sex-based and age-dependent effect on the clinical expression of erythema nodosum in Crohn's disease. This suggests that some components of the inflammatory process in Crohn's disease may be modulated by estrogen-mediated events, particularly in adolescents and young adults.

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13

Bunick, Christopher G., Omer Ibrahim, and Brett A. King. "When erythema ab igne warrants an evaluation for internal malignancy." International Journal of Dermatology 53, no. 7 (March 6, 2014): e353-e355. http://dx.doi.org/10.1111/ijd.12329.

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14

Pignoli, E., L. Lozza, M. De Santis, M. Carrara, T. Giandini, T. Rancati, N. Zaffaroni, and R. Valdagni. "Spectrophotometric Evaluation of Skin Erythema in Patients Undergoing Breast Irradiation." International Journal of Radiation Oncology*Biology*Physics 87, no. 2 (October 2013): S689—S690. http://dx.doi.org/10.1016/j.ijrobp.2013.06.1829.

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15

Dolotov, L. E., Yu P. Sinichkin, V. V. Tuchin, S. R. Utz, G. B. Altshuler, and I. V. Yaroslavsky. "Design and evaluation of a novel portable erythema-melanin-meter." Lasers in Surgery and Medicine 34, no. 2 (2004): 127–35. http://dx.doi.org/10.1002/lsm.10233.

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16

Komishke, Bailey, Jessica L. Foulds, Tamara McMillan, and Nicholas Avdimiretz. "Bilateral leg swelling as the presenting symptom of Löfgren syndrome in a paediatric patient: a rare presentation of a rare paediatric disease." BMJ Case Reports 14, no. 3 (March 2021): e239434. http://dx.doi.org/10.1136/bcr-2020-239434.

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A 17-year-old previously healthy man presented with a 4-week history of progressive bilateral leg swelling with discomfort and erythema, but no signs of arthritis or erythema nodosum. An incidental finding of a query pulmonary nodule on chest X-ray prompted chest CT for further evaluation, revealing bilateral hilar and mediastinal lymphadenopathy. The patient then underwent endobronchial ultrasound and transbronchial needle aspiration biopsies of mediastinal lymph nodes. Biopsies and bronchoalveolar lavage samples were negative for microbiology, including mycobacterial culture. Pathology demonstrated non-caseating granulomas consistent with a diagnosis of sarcoidosis. Weeks later, he developed arthralgias of the left metacarpophalangeal joints and erythema nodosum and was diagnosed with Löfgren syndrome, a phenomenon rarely described in the paediatric population. This case highlights an approach to lower extremity swelling as well as hilar lymphadenopathy in the paediatric population. In addition, it emphasises the importance of multidisciplinary teamwork for accurate and timely diagnoses.

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Laroche, Alexandre, Evelyn Alarcon Chinchilla, Emilie Bourgeault, and Marc-André Doré. "Erythema Nodosum as the Initial Presentation of Nivolumab-Induced Sarcoidosis-Like Reaction." Journal of Cutaneous Medicine and Surgery 22, no. 6 (May 17, 2018): 627–29. http://dx.doi.org/10.1177/1203475418776934.

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Background: We report a case of nivolumab-related sarcoidosis-like syndrome that initially presented with erythema nodosum. Sarcoidosis development has been described in single and combination immunotherapy. Case Presentation: A 68-year-old white woman with metastatic ocular amelanotic choroid melanoma was treated with nivolumab. The patient developed histologically confirmed erythema nodosum lesions and pulmonary granuloma sarcoidosis. Nivolumab was discontinued and the patient started ipilimumab therapy. Conclusion: Sarcoidosis-like syndrome with lymphadenopathy is a rare adverse event that is important to recognize since it can be mistaken for metastatic disease progression. Tissue biopsy of new lesions during immunotherapy is an important step in patient evaluation.

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Arisi, Mariachiara, Maria Teresa Rossi, Marta Fusano, Alessandra Gualini, Cesare Tomasi, Erica Moggio, Simone Caravello, Piergiacomo Calzavara-Pinton, and Marina Venturini. "Clinical and Spectrophotometric Evaluation of Skin Photoadaptation in Vitiligo Patients after a Short Cycle of NB-UVB Phototherapy." Dermatology 235, no. 6 (2019): 509–15. http://dx.doi.org/10.1159/000502853.

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Background: The phenomenon of photoadaptation to narrow-band ultraviolet B (NB-UVB) radiation has been previously described in vitiligo and has usually been clinically measured by the assessment of the minimal erythema dose (MED) after phototesting. Objectives: To assess the photoadaptive response in vitiligo and healthy skin after NB-UVB phototherapy not only clinically, but also by spectrophotometry. Materials and Methods: Fourteen patients affected by generalized vitiligo underwent NB-UVB phototherapy twice weekly for 12 weeks. Before and after phototherapy, a phototesting procedure was administered on vitiligo patches and adjacent healthy skin with a solar simulated radiation (SSR). Visual assessment of the MED took place after 24 h. A spectrophotometer was used to assess the a* value and the melanin index (MI*), as signs of skin erythema and pigmentation. The photoadaptation factor (MED-PF) and the a* photoadaptation factor (a*-PF) were calculated. Results: After NB-UVB phototherapy, both vitiligo and healthy skin showed an increase in MED and MI* values and a reduction of skin erythema compared to baseline (p < 0.05). MED-PF data showed a photoadaptation in 10 (71.4%) vitiligo lesions and in 12 (85.7%) healthy skin areas. The assessment of the a*-PF showed a negative mean percentage value in all affected and unaffected skin areas. Conclusions: A short cycle of NB-UVB phototherapy can induce photoadaptation in vitiligo by increasing the MED and reducing skin erythema after stimulation with SSR. This is most likely due to the physical filter function induced by ultraviolet radiation.

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Grkovic, Lana, Sandra A. Mitchell, Kristin Baird, Seth M. Steinberg, Edward W. Cowen, Kirsten M. Williams, Manuel B. Datiles, et al. "Assessing the Validity of the NIH Response Criteria for Chronic Graft-Versus-Host Disease (cGVHD): Consensus Measures Correlate with Clinical Outcomes,." Blood 118, no. 21 (November 18, 2011): 4074. http://dx.doi.org/10.1182/blood.v118.21.4074.4074.

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Abstract Abstract 4074 Background: Lack of standardized criteria for measuring therapeutic response remains a significant obstacle to the evaluation of new cGVHD treatments. In 2005 an NIH consensus conference proposed a set of organ-specific measures for quantification of change after a therapeutic intervention (BBMT 2006, 12:252). We conducted a cross-sectional prospective study to validate the NIH response criteria by analyzing the correlations between proposed clinician (Form A) or patient reported (Form B) scales and the set of established clinically important outcomes: NIH global severity, average NIH organ score, sub-specialist evaluations (SSE), disease activity by therapeutic intent, Lee symptom scale, SF-36 (PCS, MCS), HAP score (MAS, AAS) and overall survival (OS). Patients and Methods: 193 adults, age 48 years, (18–70) were enrolled from 2004–2011 on the NCI cGVHD natural history protocol at a median of 36 months (4–258) from transplant. Patients received a median of 4 (0–9) prior systemic therapies, and 83% were on systemic immunosuppression, 67% had severe, 30% had moderate and 3% had mild NIH global score. Median number of involved organs was 5 (1–8). NIH response criteria measures were obtained at the time of study entry. Univariate and multivariate logistic regression analysis were undertaken to determine correlations between response criteria items and outcomes. Results: The median values of the NIH response criteria items were: Clinician reported – Skin %BSA (erythema 0.9 [0–80], moveable sclerosis 0.54 [0–81], non-moveable sclerosis 0 [0–76]), Schirmer 1 tear test (mm) 3 [0–29.5], oral scale 1 [0–12], WBC 7.1 [1.96–31.3], AST 32 [5–256], bilirubin 0.5 [0.1–1.7], gastrointestinal (upper 0 [0–3], esophageal 0 [0–3], lower, 0 [0–3]), lung function score (LFS) 4 [0–12], health care provider global rating (HCP) 2 [0–3], clinician rated symptom severity 6 [0–10], clinician evaluation of change 0 [-3-+3], grip strength (psi) 66 [1–138], walk time (feet/min) 109 [40–145], Karnofsky score (KPS) 80 [30–100]. Patient reported - symptoms intensity (skin itching 2 [0–10], mouth dryness 2 [0–10] pain 0 [0–10] or sensitivity 1 [0–10], eyes 5 [0–10], patient global score 2 [1–3], patient rated symptom severity 5 [0–10], patient evaluation of change 0 [-3-+3]. Most of the elements had statistically significant association with clinical outcomes in univariate analyses. Multivariable analyses demonstrated associations between response criteria items and outcomes (Table 1). Schirmer tear test, oral score, WBC, AST, lower GI symptoms, grip strength, skin itching intensity and clinician or patient evaluation of cGVHD change did not show significant associations with any of the outcomes. 3-year survival for the cohort is 75%. Median follow-up of surviving patients was 33 months. Factors associated with OS included: BSA% erythema (p=0.0018), LFS (p=0.014), walk velocity (p=0.018), KPS (p<0.0001), and mouth pain (p=0.03). In the Cox proportional hazards model higher BSA% erythema (>3.0%, p=0.0126; HR=2.5; 95 CI: 1.2–5.1), higher LFS (>=8, p=0.0218; HR 2.3, 95 CI: 1.1–4.8) and lower KPS (30–70%, p=0.02; HR=2.3; 95 CI: 1.1–4.7) predicted lower OS. Conclusions: A number of response criteria measures proposed by the NIH cGVHD consensus project predict important clinical outcomes. These results thus identify a subset of measures that may serve as surrogate endpoints and should be prioritized for further evaluation in clinical studies. Disclosures: No relevant conflicts of interest to declare.

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Welch, Laura. "Impairment Tutorial: Dermatological Impairment Assessment." Guides Newsletter 3, no. 5 (September 1, 1998): 6–7. http://dx.doi.org/10.1001/amaguidesnewsletters.1998.sepoct03.

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Abstract The main function of the skin is to protect the body that it encloses. Anatomically and physiologically, the skin's regions differ to the extent that skin is not one organ but a combination of multiple systems. The skin has a limited range of reaction patterns, but these may express a wide range of clinical syndromes. The AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) states that the morphology of the lesion and the pattern of distribution suggest the differential diagnosis. Skin lesions can be characterized as macule, papule, change in pigmentation, plaque, erythema, or eczema. The evaluating physician should consider relevant characteristics, including: Is the condition localized or generalized? Does in involve the face or spare it? Does the condition involve or spare the palms and soles? Approximately 95% of occupational skin disease involves contact dermatitis from irritation, contact allergy, or both. The remaining instances usually arise from biological, physical, mechanical, or other miscellaneous causes. The AMA Guides directs the evaluating physician to complete a detailed work description and conduct a physical examination with biopsy or patch testing as needed. Because most cases of occupational contact dermatitis involve irritants, a systematic approach to examination of the skin and use of good dermatology tests can pinpoint the diagnosis in the majority of cases.

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Roujeau, J. C. "Re-evaluation of ‘drug-induced’ erythema multiforme in the medical literature." British Journal of Dermatology 175, no. 3 (August 3, 2016): 650–51. http://dx.doi.org/10.1111/bjd.14841.

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Procaccini, E. M., G. Riccio, L. Casula, G. Posteraro, and G. Monfrecola. "Thirty Hours’ Evaluation of UVB-lnduced Erythema by Chromometry and Microflowmetry." Dermatology 195, no. 4 (1997): 317–20. http://dx.doi.org/10.1159/000245979.

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Schwaiger, M., K. Schulmeister, H. Brusl, and P. Kindl. "Ultraviolet Hazard Evaluation using Different International Guidelines and Minimal Erythema Dose." Radiation Protection Dosimetry 91, no. 1 (September 2, 2000): 227–30. http://dx.doi.org/10.1093/oxfordjournals.rpd.a033206.

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Matsuyama, Joy R., and Karl K. Kwok. "A Variant of the Chemotherapy-Associated Erythrodysesthesia Syndrome Related to High-Dose Cyclophosphamide." DICP 23, no. 10 (October 1989): 776–79. http://dx.doi.org/10.1177/106002808902301007.

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A 33-year-old woman with stage IIIA non-Hodgkin's lymphoma unresponsive to ten cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) developed a variant of the chemotherapy-associated erythrodysesthesia syndrome following high-dose cyclophosphamide and radiation in preparation for an autologous bone marrow transplant. The patient first complained of a new rash on her fingers and toes on day 6 after her first dose of cyclophosphamide. Unlike the previous case reports in which patients presented with a palmar-plantar erythema, this patient's rash occurred on the dorsal aspects of her hands and feet, and not on her palms and soles. After evaluation by a dermatologist she was diagnosed as having a variant of palmar-plantar erythema induced by cyclophosphamide.

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Korgavkar, Kaveri, Elnaz F. Firoz, Michael Xiong, Robert Lew, Kimberly Marcolivio, Nancy Burnside, Robert Dyer, and Martin A. Weinstock. "Measuring the Severity of Topical 5-Fluorouracil Toxicity." Journal of Cutaneous Medicine and Surgery 18, no. 4 (July 2014): 229–35. http://dx.doi.org/10.2310/7750.2013.13143.

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Background: Topical 5% 5-fluorouracil (5-FU) is known to cause toxicity, such as erythema, pain, and crusting/erosions. Objectives: We sought to develop a scale to measure this toxicity and test the scale for reliability. Methods: A scale was developed involving four parameters: erythema severity, percentage of face involved in erythema, crusting/erosions severity, and percentage of face involved in crusting/erosions. Thirteen raters graded 99 sets of photographs from the Veterans Affairs Keratinocyte Carcinoma Chemoprevention (VAKCC) Trial using these parameters. Results: Intraclass correlation overall for 13 raters was 0.82 (95% CI 0.77–0.86). There was no statistically significant trend in reliability by level of training in dermatology. Conclusions: This scale is a reliable method of evaluating the severity of toxicity from topical 5-fluorouracil and can be used by dermatologists and nondermatologists alike.

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Ványai, Beatrix, Imre Veres, Andrea Szegedi, and Irina Sawhney. "Diferential diagnostic difculties of fgurate erythemas -a case report." Bőrgyógyászati és Venerológiai Szemle 97, no. 1 (March 1, 2021): 45–49. http://dx.doi.org/10.7188/bvsz.2021.97.1.6.

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The authors describe the case of a 42-year-old woman with typical targetoid lesions of erythema multiforme. The histopathological examination confrmed the diagnosis, local and systemic corticosteroid were started. Following the treatment initiation, symptoms showed regression. While tapering the systemic therapy, symptoms recurred and showed slightly changed clinical picture as well. Second histopathological examination confrmed. The diagnosis of erythema annulare centrifugum. After ophthalmological examination systemic chloroquine therapy was started, which resulted in gradual improvement of the symptoms. The authors summarized by evaluating this patient’s case the diferential diagnostic difculties of fgurate erythemas.

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Aronson, Iris K., Jean A. Rumsfield, Dennis P. West, Julia Alexander, James H. Fischer, and Frank P. Paloucek. "Evaluation of Topical Metronidazole Gel in Acne Rosacea." Drug Intelligence & Clinical Pharmacy 21, no. 4 (April 1987): 346–51. http://dx.doi.org/10.1177/106002808702100410.

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Topical metronidazole gel (0.75%) was compared to placebo gel in a randomized, double-blind, placebo-controlled, split-face clinical trial for the treatment of 59 patients with acne rosacea. Statistically significant differences in inflammatory lesions, erythema, and global assessments were seen at three, six, and nine weeks post-baseline in favor of the active treatment side. It did not, however, alter the telangiectatic component of the disease. No known drug-related side effects were detected, and the low topical dose along with low serum levels of metronidazole indicate a high safety profile for this therapeutic agent. This work suggests that metronidazole gel, as specifically formulated, is safe and effective in reducing the symptomatology of acne rosacea.

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Tinawi, Mohammad. "Unusual Case of Localized Upper Limbs and Truncal Edema Associated with Fever, Anemia, and Acute Kidney Injury." Case Reports in Medicine 2019 (November 22, 2019): 1–3. http://dx.doi.org/10.1155/2019/6251426.

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The patient is a 75-year-old man who presented with right arm pain, edema, and erythema. The same manifestations appeared in the other arm 3 weeks later. He also developed fever, acute kidney injury, anemia, and truncal edema. Initial extensive evaluation was unrevealing. He was noted to have elevated creatine kinase, and a diagnostic muscle biopsy lead to diagnosis of inflammatory myositis. He improved with corticosteroids.

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Fam, Vivien W., Roberta R. Holt, Carl L. Keen, Raja K. Sivamani, and Robert M. Hackman. "Prospective Evaluation of Mango Fruit Intake on Facial Wrinkles and Erythema in Postmenopausal Women: A Randomized Clinical Pilot Study." Nutrients 12, no. 11 (November 4, 2020): 3381. http://dx.doi.org/10.3390/nu12113381.

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Mangos are rich in β-carotene and other carotenoids, along with several phenolic acids that may provide oxidant defense and photoprotection to the skin. The objectives of this study are to investigate the effects of Ataulfo mango intake on the development of facial wrinkles and erythema. A randomized two-group parallel-arm study was conducted to assess 16 weeks of either 85 g or 250 g of mango intake in healthy postmenopausal women with Fitzpatrick skin type II or III. Facial photographs were captured at weeks 0, 8, and 16, and wrinkles at the lateral canthi and erythema at the cheeks were quantified. Skin carotenoid values were measured with reflection spectroscopy. Deep wrinkle severity decreased significantly in the 85 g group after 8 (p = 0.007) and 16 (p = 0.03) weeks compared to baseline measures. In contrast, those in the 250 g group showed an increase after 16 weeks in average wrinkle severity (p = 0.049), average wrinkle length (p = 0.007), fine wrinkle severity (p = 0.02), and emerging wrinkle severity (p = 0.02). Erythema in the cheeks increased with 85 g of mango intake (p = 0.04). The intake of 85 g of mangos reduced wrinkles in fair-skinned postmenopausal women, while an intake of 250 g showed the opposite effect. Further studies feeding 85 g of mangos are warranted.

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Nose, Takashi, Atsushi Uchiyama, and Kaito Tsurumi. "Study on the ultraviolet erythema in guinea-pigs. (III) Pharmacological comparison of ultraviolet erythema with other erythema models by quantitative evaluation method using a portable chromameter." Japanese Journal of Pharmacology 46 (1988): 296. http://dx.doi.org/10.1016/s0021-5198(19)57728-9.

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Harcus, A. W., A. E. Ward, J. St C. Roberts, and K. A. Bryett. "An Evaluation of Diphtheria — Tetanus (Adult) Vaccine in Unselected Human Volunteers." Journal of International Medical Research 17, no. 3 (May 1989): 262–67. http://dx.doi.org/10.1177/030006058901700309.

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One hundred unselected adult volunteers received an adult diphtheria (<2 Lf)-tetanus (?40 IU) adsorbed vaccine without prior Schick testing. No volunteer had a moderate or severe reaction although 39% complained of a transient sore arm. Only 10% reported local erythema. Of the study group, 37/43 (86%) patients who were initially seronegative for diphtheria attained levels normally considered as seropositive. The results confirm the safety and efficacy of adult diphtheria – tetanus vaccine and allow its recommendation for use in ‘at risk’ individuals without the need for prior Schick testing.

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Fujii, Masashi, Masaru Ueki, Kazutake Uehara, Kazuo Yashima, Koichiro Kawaguchi, Yuichiro Ikebuchi, Hidehito Kinoshita, et al. "Pain Evaluation During Colonoscopy by the Erythema Index of the Facial Image." Yonago Acta Medica 62, no. 1 (2019): 100–108. http://dx.doi.org/10.33160/yam.2019.03.014.

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Wengström, Yvonne, Christina Forsberg, Ingemar Näslund, and Jonas Bergh. "Quantitative assessment of skin erythema due to radiotherapy—evaluation of different measurements." Radiotherapy and Oncology 72, no. 2 (August 2004): 191–97. http://dx.doi.org/10.1016/j.radonc.2004.04.011.

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Moneib, H. A. M., S. A. M. Salem, and M. M. Darwish. "Evaluation of zinc level in skin of patients with necrolytic acral erythema." British Journal of Dermatology 163, no. 3 (April 23, 2010): 476–80. http://dx.doi.org/10.1111/j.1365-2133.2010.09820.x.

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Bagg, J., and H. Moseley. "Evaluation of an optical instrument for objective assessment of oral mucosal erythema." Journal of Oral Rehabilitation 25, no. 7 (July 1998): 496–501. http://dx.doi.org/10.1046/j.1365-2842.1998.00269.x.

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Cugmas, Blaž, and Thierry Olivry. "Evaluation of skin erythema severity by dermatoscopy in dogs with atopic dermatitis." Veterinary Dermatology 32, no. 2 (January 6, 2021): 183. http://dx.doi.org/10.1111/vde.12932.

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37

Olmsted, Kari A. "Upper-Extremity Venous Duplex Evaluation." Journal for Vascular Ultrasound 29, no. 2 (June 2005): 79–83. http://dx.doi.org/10.1177/154431670502900205.

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As many as 80% of upper-extremity venous thrombosis cases develop in response to an easily identified problem, such as central venous catheter. The remaining 20% of obstructions are caused by other central venous obstruction, trauma, or Paget-Schroetter syndrome. Appropriate clinical indications for upper-extremity venous duplex evaluation include (but are not limited to) unilateral upper-extremity swelling in the presence of indwelling central venous catheter, upper-extremity erythema and tenderness, superficial palpable cord, or facial swelling. Physical examination and thorough patient history compliment the duplex findings to arrive at an accurate diagnosis. The most effective way to determine the presence or absence of thrombosis is with vein wall compressions. However, most of the upper-extremity central vein segments are located beneath bony structures, which prevent extrinsic compression with transducer pressure. Therefore, the spectral Doppler waveform analysis component of the duplex exam becomes crucial in determining venous obstruction. Common technical components and pitfalls include appropriate color and spectral Doppler settings to reliably demonstrate presence/absence of flow or accurate accounting for innominate vein and supraclavicular/infraclavicular subclavian vein versus occluded native anatomy and large patent branches. When properly executed, the aforementioned components comprise a thorough duplex evaluation of the upper extremity venous system.

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Sari, Desy Diana, Lidya Ameliana, and Dwi Nurahmanto. "Optimasi Asam Glikolat dan Asam Sitrat dalam Krim Tabir Surya Kombinasi Titanium Dioksida, Avobenzone dan Octyl Methoxycinnamate." Pustaka Kesehatan 8, no. 3 (September 18, 2020): 139. http://dx.doi.org/10.19184/pk.v8i3.12266.

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Ultraviolet (UV) radiation is the main cause of sunburn and skin cancer. The adverse effects of UV radiation are solved by sunscreen as protection for longer outdoors. In this study, optimization of glycolic acid and citric acid in sunscreen cream combination of titanium dioxide, avobenzone, and octyl methoxycinnamate were investigated using simplex lattice design method. The sunscreen cream evaluation includes physicochemical testing (organoleptic, homogeneity, emulsion type, spreadability, viscosity, and pH) and sunscreen effectiveness (SPF, % erythema transmission, and % pigmentation transmission). The value of physicochemical testing are 5,96 cm - 6,3 cm of spreadability testing; 83,33 dPa.s – 108,33 dPa.s of viscosity testing; 4,06 – 4,67 of pH testing. The value of sunscreen effectiveness are 9,79 – 13,35 of SPF testing; 4,55x10-06 - 0,15x10-06% of % erythema transmission; 5,77 – 7,16 % of % pigmentation transmission. The optimum formula was obtained by combining glycolic acid 2% and citric acid 0% with a desirability value of 0,649.

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Huang, Alisen, Julie K. Nguyen, Evan Austin, Andrew Mamalis, Marc Cohen, Boris Semkhayev, Derek Ho, and Jared Jagdeo. "Facial rejuvenation using photodynamic therapy with a novel preparation of ALA and hyaluronic acid in young adults." Archives of Dermatological Research 312, no. 8 (February 14, 2020): 567–73. http://dx.doi.org/10.1007/s00403-020-02038-5.

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Abstract Photodynamic therapy (PDT) is a well-established, non-invasive treatment modality that has shown desirable effects such as improvement of fine lines, dyspigmentation, and other signs of photodamage. Many patients seek to decrease, or reverse, effects of sun damage on the skin. Hyaluronic acid (HA), a naturally occurring glycosaminoglycan found in the body, has enormous potential to bind water which allows the skin to retain moisture and maintain elasticity. Topical application of HA has been found to produce anti-wrinkle effects. We conducted a pilot case series evaluating the safety and efficacy of a commercially available 2% 5-aminolevulinic acid (ALA) gel with hyaluronic acid (ALA-HA) and light-emitting diode-red light (LED-RL) for facial rejuvenation as determined by clinical assessments and digital skin analysis of rhytides, pore size, and erythema. All patients noted improvement of their skin and experienced minimal pain during PDT. Evaluation by dermatologists demonstrated significant improvement in overall skin appearance. Digital analysis of photographs revealed improvement of skin spots, wrinkles, pores, texture, UV spots, brown spots, red areas, and porphyrins. Our findings demonstrated safety and efficacy of this novel preparation of photodynamic gel with HA and subsequent activation with LED-RL.

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Shatokhina, Evgeniya A., Larisa S. Kruglova, and Oleg A. Shukhov. "Clinical evaluation of the effectiveness of treatment of the hand-foot syndrome – skin toxicity of antitumor target therapy with multi-kinase inhibitors." Endocrine Surgery 12, no. 3 (December 27, 2018): 140–49. http://dx.doi.org/10.14341/serg9704.

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Background. The effective treatment of the hand-foot syndrome is a necessary component of the complex treatment of patients receiving antitumor therapy with multikinase inhibitors. Aims. The assessment of a new effective method for the treatment of palm-plantar syndrome in patients receiving multi-kinase inhibitors. Materials and methods. There are 27 patients received antitumor treatment with multi-kinase inhibitors and had clinical manifestations of the hand-foot syndrome (HFS) for observation. The main group (14 patients) used a combination of an alpha-lipoic acid at a dose of 600 mg per day per os and an ointment containing 0.005% calcipotriol and 0.05% betamethasone dipropionate 2 times a day. The control group, included 13 patients, used a combination with a cream containing 10% urea and ointment containing 0.05% betamethasone dipropionate. Results. After a week of treatment, the regression of the skin process was observed in both groups, but it was more evident in the main group: significant differences in severity of erythema, paresthesia, pain and burning sensation, the Dermatological Life Quality Index (DLQI) were observed at this stage of therapy (p < 0.05). After 2 weeks of therapy: a more positive trend in the main group in terms of erythema, paresthesia and burning, but the most significant difference is DLQI – 17.4 in the main group and 22.8 in the control group (p < 0.0001). At the end of the 3rd week of therapy: differences with the main characteristics of erythema, desquamation, paresthesia (p < 0.0008), pain (p < 0.0001), DLQI (p < 0.0001). At the end point of the study (after 4 weeks of therapy), significant differences were found in reducing the symptoms and the main parameters for evaluating the effectiveness of DLQI in patients of the main group with a reliability of p < 0.0001. The high correlation of DLQI was found with erythema, pain, burning, paresthesia and desquamation. Conclusions. The treatment of the hand-foot plantar syndrome combined using alpha-lipoic acid inside and topical therapy in the form of an ointment containing calcipotriol and betamethasone dipropionate, can be recommended for patients receiving targeted therapy with multi-kinaseinhibitors.

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Croitoru, David, Stephanie G. Brooks, Vincent Piguet, and Lindsey MacGillivray. "Cetirizine-induced psychosis in a young adult with erythema multiforme." BMJ Case Reports 14, no. 2 (February 2021): e241393. http://dx.doi.org/10.1136/bcr-2020-241393.

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We describe a case of a young man, taking no other routine medications, presenting with erythema multiforme and cetirizine-induced psychosis with re-challenge evidence. On retrospective elicitation of history, it was found that he had been involved in a motor vehicle collision 4 months prior and was a daily cannabis user; there were no objective abnormalities by MRI and neurological evaluations. Although rare, cetirizine-induced psychosis is an important adverse drug reaction that warrants the attention of healthcare practitioners.

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Prohic, Asja, Selma Poparic, Adem Cemerlic, and Aida Kapetanovic. "Erythema Ab Igne with Histological Features of Keratosis Lichenoides Chronica." Case Reports in Dermatology 13, no. 1 (March 29, 2021): 184–89. http://dx.doi.org/10.1159/000515259.

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Erythema ab igne (EAI) is a localized, hyperpigmented and reticulated dermatosis at sites of chronic heat exposure. Within longstanding skin lesions of EAI, hyperkeratotic lesions may emerge and can potentially transform into pre-malignant or malignant skin lesions. A 55-year-old woman presented for the evaluation of multiple hyperkeratotic lesions along with a reticular patterned hyperpigmentation on her right knee, an area that had repeated and prolonged exposure to a heat source over a period of several months. Based on her clinical history and the physical examination of her lesions, she was diagnosed as having a hyperkeratotic form of EAI. A skin biopsy was performed to rule out malignant alteration, but the histopathological findings were supportive of keratosis lichenoides chronica.

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Shirin, Haim, Jonathan M. Schapiro, Nadir Arber, Jack Pinkhas, Yeheskel Sidi, and Francis Salomon. "Erythromycin Base-Induced Rash and Liver Function Disturbances." Annals of Pharmacotherapy 26, no. 12 (December 1992): 1522–23. http://dx.doi.org/10.1177/106002809202601207.

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OBJECTIVE: To report a case of erythromycin base-induced rash and liver function disturbances. CASE SUMMARY: A patient with erythema nodosum and high antistreptolysin-O titers was treated with erythromycin on the assumption that occult streptococcal infection was the cause of the erythema nodosum. Forty-eight hours after the initiation of therapy the patient developed fever, severe generalized rash, pruritus, and cholestatic and hepatocellular liver function disturbances. Extensive evaluation to determine the cause of liver function disturbances was unrevealing. Marked improvement was noticed within days after cessation of erythromycin. DISCUSSION: Case reports in the literature on the adverse effects of erythromycin and its derivatives were reviewed. The possible immunologic mechanism involved is postulated. CONCLUSIONS: Erythromycin base must be added to the list of erythromycin derivatives that can cause rash and liver function disturbances. The concomitant appearance of fever, rash, jaundice, and liver function disturbances raises the possibility of hypersensitivity as the mechanism for the liver disturbances.

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Coelho, Sergio G., Sharon A. Miller, Barbara Z. Zmudzka, and Janusz Z. Beer. "Quantification of UV-Induced Erythema and Pigmentation Using Computer-Assisted Digital Image Evaluation." Photochemistry and Photobiology 82, no. 3 (2006): 651. http://dx.doi.org/10.1562/2005-08-02-tsn-635.

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45

Marangoni, Antonella, Vittorio Sambri, Cinzia Cimmino, Giuseppe Caruso, Valeria Mondardini, and Roberto Cevenini. "Evaluation of the immune response in culture-confirmed Lyme borreliosis erythema migrans patients." Zentralblatt für Bakteriologie 289, no. 5-7 (December 1999): 736–39. http://dx.doi.org/10.1016/s0934-8840(99)80045-0.

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46

De Simone, Clara, Giacomo Caldarola, Franco Scaldaferri, Valentina Petito, Francesca Perino, Vincenzo Arena, Manuela Papini, Marzia Caproni, and Ketty Peris. "Clinical, histopathological, and immunological evaluation of a series of patients with erythema nodosum." International Journal of Dermatology 55, no. 5 (February 24, 2016): e289-e294. http://dx.doi.org/10.1111/ijd.13212.

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47

Chang, C., M. Brown, L. Davies, L. Pointon, R. Brown, and D. Barker. "Evaluation of Erytra® fully automated analyser for Routine Use in Transfusion Laboratory." Transfusion Medicine 24, no. 1 (November 5, 2013): 33–38. http://dx.doi.org/10.1111/tme.12073.

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48

Crespo, Agricio Nubiato, Carlos Takahiro Chone, Adriano Santana Fonseca, Maria Carolina Montenegro, Rodrigo Pereira, and João Altemani Milani. "Clinical versus computed tomography evaluation in the diagnosis and management of deep neck infection." Sao Paulo Medical Journal 122, no. 6 (December 2004): 259–63. http://dx.doi.org/10.1590/s1516-31802004000600006.

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CONTEXT: Deep neck infections have high potential for severe complications and even death, if not properly managed. The difference between clinical and computed tomography findings may demonstrate that clinical evaluation alone underestimates disease extent, which may lead to conservative treatment with worse prognosis. OBJECTIVE: To compare clinical and computed tomography findings from neck spaces affected by deep neck infections and to determine the main clinical and radiological features associated with these. TYPE OF STUDY: Non-randomized retrospective study. SETTING: Department of Otolaryngology and Head and Neck, Universidade Estadual de Campinas. METHODS: Medical charts of 65 patients with deep neck infections were evaluated. Age, gender, clinical complaints, physical findings, computed tomography scan and x-ray imaging, microbiology, treatment and outcome were analyzed. All clinical signs and symptoms were evaluated and stratified in order of frequency. The frequency of neck space involvement in such infections was also assessed from the clinical and tomographic evaluation. All clinical and computed tomography findings were compared with surgical observation. RESULTS: The most frequent clinical findings were neck swelling, local pain, erythema and locally increased temperature. Physical evaluation showed that the most affected site was the submandibular triangle (49.2% of cases). However, computed tomography showed this to be the lateropharyngeal space (65% of cases) and that more than one deep cervical space was compromised in 90% of cases, as demonstrated by the extent of swelling and increased contrast signs in soft tissue. DISCUSSION: The most frequent clinical symptoms of deep cervical infections were cervical pain, increased cervical volume and fever. The important signs seen via computed tomography were increased contrast in soft neck tissues and swelling. Such examination is the most important method for correct evaluation of cervical spaces involved in infection, and thus for correct surgical drainage. CONCLUSIONS: The most frequent clinical findings were cervical mass, neck pain, local erythema and locally increased temperature. Computed tomography demonstrated that the lateropharyngeal space was the most affected neck space. More than one deep neck space was compromised in 90% of cases. Clinical evaluation underestimated the extent of deep neck infection in 70% of patients.

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Husain, Md Anwar, Md Rezaur Rahim, Mohd Nurul Alam, Md Rafiqul Haque, Md Rashidul Hasan, Md Saidur Rahman, and Monalisa Ferdous. "Efficacy and Safety of Pimecrolimus Cream (1%) in the Treatment of Discoid Lupus Erythematosus." Medicine Today 30, no. 2 (August 8, 2018): 53–56. http://dx.doi.org/10.3329/medtoday.v30i2.37809.

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Discoid lupus erythematosus (DLE) is commonly treated with topical agents, the most important of which are glucocorticosteroids. However, prolonged use of these agents, especially on sensitive areas such as the face, may result in side-effects (e.g. atrophy and telangiectases) by altering collagen synthesis. This was a randomized doubleblind pilot study, performed in Department of Dermatology & VD, Ibn-Sina Sina Medical College, Dhaka. Seventy four patients aged 20-53 years with moderate to severe DLE of the face were randomized 8 weeks of treatment and 8 weeks of follow-up after treatment. In this double-blind study, one group applied pimecrolimus 1% cream twice daily to facial lesions. Efficacy end-points included a combined score based on evaluation of erythema, infiltration and presence of scale. This study was conducted to evaluate the efficacy and safety of topical pimecrolimus 1% cream in discoid lupus erythematosus. It was observed that before treatment, erythema was severe in 43.2% cases, moderate in 51.4% cases and mild type erythema was present in 5.4% cases. The post-treatment revealed, 29.7% severe type erythema, none evidenced moderate type erythema, only 43.2% had mild type and 27% cases no erythema at all. Before treatment, infiltration was severe in 27% cases, moderate in 54.1% cases and only 18.9% had mild type infiltration. But after treatment, 10.8% had severe type infiltration, 18.9% had moderate, 51.4% had mild and 18.9% had no infiltration at all. Similar response to treatment was noticed with squamation which exhibited a drop from 37.8% to 18.9% in severe cases and from 62.2% to 10.8% in moderate cases. There was a 45.9% mild case and 24.3% had no squamous. It was interpreted that score of patients of DLE, before treatment was 6.78±1.36 and after treatment was 3.97±1.21. Improvement was shown in 70.3 cases and 29.73 cases shown no improvement at all. This study suggest that pimecrolimus cream for discoid lupus erythematosus seems to be a safe and clinically effective option. However, this was an open and uncontrolled study, and double-blind, placebo-controlled studies are needed.Medicine Today 2018 Vol.30(2): 53-56

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Doshi, Kartik, Ashish Varghese, and Dinesh K. Badyal. "Evaluation of Omeprazole in the Treatment of Laryngopharyngeal Reflux Disease: A Single Center, Prospective and Randomized Study." An International Journal of Otorhinolaryngology Clinics 7, no. 2 (2015): 45–50. http://dx.doi.org/10.5005/jp-journals-10003-1186.

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ABSTRACT Aims To assess efficacy and safety of omeprazole in laryngitis due to laryngopharyngeal reflux disease (LPRD). Materials and methods It was a prospective, randomized, open label study conducted in 90 patients with laryngitis due to LPRD. Group A (n = 45) received omeprazole and advice about life style modification, group B (n = 45) received only advice about life style modification. Reflux symptom index (RSI), reflux finding score (RFS), quality of life (QoL) and voice handicap index (VHI) were evaluated at 0, 4 and 8 weeks. Results P ercentage r eduction i n R SI a nd R FS w as s ignificantly higher in group A after 8 weeks (37 vs 29%, 18 vs 13% respectively). Excess throat mucus, clearing of throat and erythema of posterior larynx improved considerably in group A compared to group B. Conclusion Omeprazole could be a significant addition to life style modification in LPRD patients particularly for signs and symptoms, such as excess throat mucus, clearing of throat and erythema of posterior larynx. How to cite this article Doshi K, Varghese A, Badyal DK. Evaluation of Omeprazole in the Treatment of Laryngopharyngeal Reflux Disease: A Single Center, Prospective and Randomized Study. Int J Otorhinolaryngol Clin 2015;7(2):45-50.

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