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Journal articles on the topic 'Erythematous Squamous'

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Published: 5 June 2025

Last updated: 16 July 2025

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Reddy, B. Rajasekhar, and Nalini Krishna M. "Histopathological spectrum of non-infectious erythematous, papulo-squamous lesions." Asian Pacific Journal of Health Sciences, Supplimentary 2014 (2014): 28–34. http://dx.doi.org/10.21276/apjhs.2014.1.1s.6.

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Karasińska, Aneta, Adriana Polańska, Monika Bowszyc‑Dmochowska, Ryszard Żaba, Zygmunt Adamski, and Aleksandra Dańczak‑Pazdrowska. "Discoid lupus erythematosus – a case report, diagnostic and therapeutic difficulties." Journal of Face Aesthetics 4, no. 2 (2021): 135–44. http://dx.doi.org/10.20883/jofa.51.

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Discoid lupus erythematosus is the most common clinical manifestation of lupus erythematosus. Characteristic features are erythematous plaques with follicular hiperkeratosis, clearly demarcated from surrounding skin, that resolve with atrophy and scarring, leading to significant aesthetic defects. The consequence of involving the scalp is cicatrical alopecia. On the ground of long lasting, untreated lesions squamous cell carcinoma (SCC) may develop. On the other hand SCC remains in the circle of DLE differentiation. We present diagnostic and therapeutic difficulties associated with DLE.

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Mavlyanova, Sh Z., Sh N. Mirzakulova, A. I. Ismogilov, J. B. Mullakhanov, and G. R. Ibragimova. "Clinical characteristics of atopic dermatitis in children in the hot climate of Uzbekistan." Juvenis Scientia 8, no. 3 (2022): 22–30. http://dx.doi.org/10.32415/jscientia_2022_8_3_22-30.

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Introduction. Atopic dermatitis (AD) is a global problem of the 21st century, as the number of people suffering from this disease is steadily increasing, and around the world, about 20% of the population with clinical manifestations of this disease seek medical help. Aim of the study. Evaluation of the clinical course of AD in children in the hot climate of Uzbekistan. Patients and methods. 215 patients with atopic dermatitis aged from 1 to 18 years were under observation. The severity of AD was determined using the SCORAD index. Results. Among 215 patients, the erythematous-squamous form was observed in 63 (29.3%), erythematous-squamous with lichenification - in 47 (21.8%), lichenoid - in 55 (25.6%), exudative - in 34 (15.8%), and pruriginous form of AD - in 16 (7.4%). Most observed patients were adolescents, and the number of boys and girls with AD in this group was similar (49.6% and 50.4%, respectively). In terms of severity, taking into account the SCORAD index, in infancy, most patients had moderate (47.4%) and mild (36.8%) clinical course; in childhood - moderate (56.1%); in adolescence - moderate (40.3%) and severe (33.8%). In infancy, the exudative form was the most prevalent (52.6%). At the age of 2 to 11 years, the erythematous-squamous and lichenoid forms were the most frequently diagnosed (43.8% and 31.6% of cases, respectively). Meanwhile, at the age of 12 to 18 years, the patients were characterized by a different distribution of forms: the erythematous-squamous form with lichenification was observed in 28.1%, the lichenoid form - in 26.6%, and the erythematous-squamous form in 20.8%. Conclusion. In the present study, we assessed the relative frequency of forms of atopic dermatitis in children of different age groups in the hot climate of Uzbekistan.

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Karki, S., and A. K. Jha. "DLE Progressing to Squamous Cell Carcinoma: A Case Report." Nepal Journal of Dermatology, Venereology & Leprology 14, no. 1 (2016): 51–55. http://dx.doi.org/10.3126/njdvl.v14i1.15839.

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A 90 years female diagnosed as a case of Discoid lupus erythematosus (DLE) developed Squamous cell carcinoma from the lesions over a period of 5 years due to treatment gap and late follow up. Diagnosis was based on clinical aspects (erythematous, nodular and scanty bleeding), dermoscopic features and histopathological examination, the absence of systemic involvement and routine laboratory parameters, which registered all within normal range.SCC in a patient with DLE is rare in Nepalese patients. It is every essential to counsel the diagnosed cases of DLE and warn all patients about all the possible outcomes and compliance with medications should be ensured.Nepal Journal of Dermatology, Venereology & Leprology, Vol.14(1) 2016, pp.51-55

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Tepluyk, N. P., O. V. Grabovskaya, Lyailya N. Kayumova, S. A. Mishin, and D. V. Mak. "Multiple erythematous-squamous foci in visible skin areas." Russian Journal of Skin and Venereal Diseases 23, no. 4 (2020): 272–74. http://dx.doi.org/10.17816/dv48923.

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The photo task in the form of multiple erythematous-squamous foci in open areas of the skin in a 60-year-old patient is described. The trigger factor for this disease was insolation. Diagnosis was verified histologically.

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Shubam, Sharma, and Vinod Sharma Prof. "Comparison of Machine Learning Techniques in the diagnosis of Erythematous Squamous Disease." Journal of Scientific Research and Technology (JSRT) 1, no. 4 (2023): 1–9. https://doi.org/10.5281/zenodo.8218863.

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Diagnosing a medical condition and its root cause is an involved procedure that calls for much investigation and knsowledge. Before making any health-related choices, it's crucial to have accurate information. Making a doctor's appointment is the first step in getting a diagnosis if you suspect you're unwell. The primary goal of this study is to develop a system for illness classification using machine learning techniques. The first step is to gather and prepare the data for analysis. Uncertainty in the dataset caused by noise, outliers, or missing values will be removed during pre-processing. Separate sets of Training data and Test data will be created from the preprocessed dataset. Machine learning algorithms will be used to train the model, and the resulting model will be put to the test on a separate dataset. The effectiveness of the algorithms being used in production will then be evaluated.

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Sherpa, Palzum, and Amit Amatya. "Histomorphological evaluation of non-neoplastic cutaneous disorders." Journal of Pathology of Nepal 10, no. 2 (2020): 1695–701. http://dx.doi.org/10.3126/jpn.v10i2.30515.

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Background: The similarity in clinical presentations of a wide gamut of non-neoplastic cutaneous pathology leads to diagnostic challenges. Histopathological study of skin biopsy aids in the accurate identification of skin lesions so that they can be managed appropriately. Materials and Methods: A retrospective descriptive study was performed in the Department of Pathology at Patan Academy of Health Sciences from April 2017 to March 2020. Data from the histopathology database were analyzed using SPSS version 17.0. Results: Non-neoplastic lesions constituted 180 cases (31.86%) of the total of 565 skin biopsies received during the study period. The age ranged from 5 months to 95 years with a mean age of 36 years. There was no overall particular gender predilection. Amongst the diagnostic categories, the prevalence of non-infectious erythematous, papular, and squamous diseases was the highest followed by microbial diseases and non-infectious vesiculobullous and vesiculopustular diseases. Lichen planus followed by urticaria was the most frequently encountered lesions in non-infectious erythematous, papular, and squamous diseases. Leprosy was the commonest microbial disease. In the non-infectious vesiculobullous and vesiculopustular category, spongiotic dermatitis was most prevalent. Spongiotic dermatitis followed by lichen planus, leprosy, and calcinosis cutis were the commonest non-neoplastic disorders. Conclusions: Amongst the diagnostic categories, the prevalence of non-infectious erythematous, papular, and squamous diseases was the highest followed by microbial diseases and non-infectious vesiculobullous and vesiculopustular diseases. In this study, spongiotic

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Garcia, Natalie, Callie Hill, Victoria Jiminez, and Carlton Blake Phillips. "Diagnostic Challenges of Hypertrophic Lupus Erythematosus." SKIN The Journal of Cutaneous Medicine 6, no. 4 (2022): 348–50. http://dx.doi.org/10.25251/skin.6.4.18.

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Hypertrophic lupus erythematosus (HLE) often occurs in the absence of systemic symptoms and can be misdiagnosed as squamous cell carcinoma (SCC) as both appear clinically as erythematous scaling plaques in sun exposed areas and histologically show significant epithelial hyperplasia. No single criterion confidently differentiates HLE from SCC histologically, postulating the need for CD123 immunostaining in evaluating locally recurring, supposed SCCs. We present a woman who presented for evaluation of multiple supposed left lower leg well-differentiated SCCs (wdSCC), that did not resolve following Mohs Micrographic Surgery and other techniques aimed at cancer removal. The lesions improved following intralesional Kenalog injection and showed positive CD123 immonostains, which both led to the diagnosis of HLE.

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Debta, Priyanka, Santosh Kumar Swain, Mahesh Chandra Sahu, et al. "Evaluation of Candidiasis in Upper-Aerodigestive Squamous Cell Carcinoma Patients—A Clinico-Mycological Aspect." International Journal of Environmental Research and Public Health 19, no. 14 (2022): 8510. http://dx.doi.org/10.3390/ijerph19148510.

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Candida is a commensal yeast. It can be infective when the host’s defense mechanism is weakened, as in the case of squamous cell carcinoma patients. We aimed to evaluate the prevalence and clinical mycological manifestation of candidiasis in 150 cancer cases comprised of preoperative and post-operative (with or without radiotherapy) upper aerodigestive squamous cell carcinoma. A total of 150 patients suffering from squamous cell carcinoma of the Upper Aero-Digestive Tract (UADT) were divided into preoperative (n = 48), post-operative without radiotherapy (n = 29) and post-operative with radiotherapy (n = 73). Samples were collected using cotton swabs and cultured. Candida species were identified according to color pigmentation on Candida Differential Agar (CDA) plate. The clinico-mycological association of patients was evaluated by the chi-square test, and 98 out of 150 patients showed the presence of various Candida species. The major species isolated was Candida albicans (53%), followed by Candida tropicalis (16%). There was a significant statistical difference between patients who showed mycological associations and patients who did not have any such association (p = 0.0008). The prevalence of oral candidiasis was found to be 65.33% among total cases of upper aero-digestive squamous cell carcinoma. Chronic erythematous cases of candidiasis were mainly seen in preoperative squamous cell carcinoma cases, whereas the acute erythematous type of candidiasis was mainly seen in post-operative cases who received radiotherapy. The clinicomycological assessment can help to correlate the signs and symptoms with the presence of candidiasis in upper aerodigestive squamous cell carcinoma patients. Meticulous testing and examination can help in the early detection of candidiasis. Future studies are needed to develop advance scientific preventive strategies for high-risk cases.

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B, Venkateshwarlu, Anumol K, Mithuna Mohan, Priyanka Bai, Murali Krishna C, and Babu G. "Review on Evidence Based Ayurvedic Treatment Practices for Psoriasis." International Journal of Ayurvedic Medicine 9, no. 2 (2018): 39–41. http://dx.doi.org/10.47552/ijam.v9i2.1098.

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Psoriasis is characterized by sharply defined erythematous squamous lesions. It is one of the commonest chronic, non-infectuous papulo-squamous disorder of the skin. Several treatment modalities are in existence in modern system of medicine; however they have limitations due to their side effects due to long time use. Considering this, search for new safe therapeutic regime in psoriasis is going on. The present paper presents some of the promising evidence based Ayurvedic therapeutic approaches in the management of psoriasis.

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Veraldi, S., P. Pontini, and G. Nazzaro. "An Erythematous-squamous Lesion of the Foot: A Quiz." Acta Dermato Venereologica 98, no. 8 (2018): 813–14. http://dx.doi.org/10.2340/00015555-2892.

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Eljebbouri, Brahim, Mohamed Allaoui, Adil Belhachmi, and Brahim El Mostarchid. "Invasive Squamous-Cell Carcinoma of the Scalp." Saudi Journal of Pathology and Microbiology 7, no. 8 (2022): 336–37. http://dx.doi.org/10.36348/sjpm.2022.v07i08.002.

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Squamous Cell Carcinoma (SCC) is an epithelial neoplasm arising from the malignant proliferation of keratinocytes and it is the second most common type of skin cancer behind basal cell carcinoma (BCC). SCC presents with a wide variety of clinical manifestations including erythematous patches and nodules although its most usual presentation includes indurated well demarcated ulcerative lesions. We present historical case of SCC of the scalp who made the extension and invasion the brain after eroding the vault.

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Reid, Stephen, Abdulaziz Althunayan, John-Paul Capolicchio, Fadi Brimo, and Wassim Kassouf. "First case of invasive squamous cell carcinoma in a stoma of a Monti ileovesicostomy." Canadian Urological Association Journal 8, no. 9-10 (2014): 654. http://dx.doi.org/10.5489/cuaj.2093.

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We report a very rare case of invasive squamous cell carcinoma (SCC) in the abdominal stoma of a Monti ileovesicostomy. Our patient underwent an uncomplicated Monti ileovesicostomy at age 16 for a neurogenic bladder. She presented 10 years later with difficulty catheterizing the stoma. A biopsy of peristomal tissue showed moderately differentiated SCC. A cystoscopy did not reveal any bladder tumours or suspicious lesions. A computed tomography (CT) scan of the abdomen and pelvis did not demonstrate metastasis. The patient underwent a complete en bloc resection of the stomal site, the Monti, a partial cuff of bladder, and 2 loops of bowel that were adherent to the Monti. Final pathology revealed pure invasive SCC arising around the stoma and negative surgical margins. Six months later, a follow-up CT scan showed no evidence of malignancy, while a cystoscopy revealed a small erythematous area in the posterior bladder wall. Urinary cytology was positive for SCC. Transurethral resection of the erythematous lesion with random bladder biopsies showed SCC in situ in the erythematous lesion and right lateral bladder wall. Staging workup was negative. The patient subsequently underwent a radical cystectomy and ileal conduit diversion with bilateral pelvic lymph node dissection. Final pathology on cystectomy specimen was SCC in situ without evidence of invasive carcinoma. The patient has remained in remission at the 3-year follow-up.

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Zhao, Min, Katamreddy Sasikumar, Masanosuke Kinoshita, et al. "Skin Squamous Cell Carcinoma Presenting as Cellulitis." Clinical Medicine Insights: Case Reports 8 (January 2015): CCRep.S18915. http://dx.doi.org/10.4137/ccrep.s18915.

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In general, skin squamous cell carcinoma (SCC) presents as papules or plaques with erythematous or pigmented appearance that may ulcerate the skin. Cellulitis caused by metastatic deposit from a known primary skin SCC has been reported once. 1 We describe a patient who presented with cellulitis on the face that did not respond well to full course of antibiotics treatment, and turned out to be a newly diagnosed SCC after biopsy. Other differential diagnoses, such as malignancy, should be suspected in all unusual presentations and biopsy should be taken if patients do not show an optimal and desired improvement after receiving a full-course of antibiotic therapy for cellulitis.

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Ghimire, RBK, and M. Mathur. "Erthroplasia of queryat- A case report." Journal of College of Medical Sciences-Nepal 7, no. 4 (2012): 67–69. http://dx.doi.org/10.3126/jcmsn.v7i4.6815.

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Erthroplassia of Queryat (EQ) is a rare squamous cell carcinoma in situ of the penis. It usually occurs on the glans penis and appears as a well-marginated erythematous velvety patch or plaque. Here, we present a case of Erthroplasia of Queryat (EQ). Journal of College of Medical Sciences-Nepal,2011,Vol-7,No-4, 67-69 DOI: http://dx.doi.org/10.3126/jcmsn.v7i4.6815

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Vakhitov, Kh M., I. N. Serdinskaya, and T. G. Malanicheva. "Outcomes of atopic dermatitis manifesting in the first year of life." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 66, no. 5 (2021): 168–71. http://dx.doi.org/10.21508/1027-4065-2021-66-5-168-171.

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For 10 years the authors analyzed 165 clinical cases of children with atopic dermatitis, which manifested in the first year of life. According to the 10-year follow-up, the authors revealed different outcomes of the disease, depending on the severity of the course, clinical forms of dermatitis and the timing of its onset. Favorable outcome with complete remission was observed in 30.9% of cases and was more common in children with a mild course of atopic dermatitis, acute exudative forms and with the onset of the disease at the age over 6 months. The transition to chronic forms was noted in 14.5% of cases and more often took place in children with a moderate severe course of the disease, erythematous-squamous forms and the onset of the disease at the age of 4–6 months. The development of respiratory forms of allergy (allergic rhinitis and bronchial asthma) was noted in 54.6% of cases and was more often detected in patients with a moderate severe and severe atopic dermatitis, erythematous-squamous forms and exudative forms with lichenification and onset of the disease in the first 3 months of life.

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Gund, Gayatri, Akansha Chadha, Atul Dongre, and Chitra Nayak. "Vulvar Sarcomatoid Squamous Cell Carcinoma: A Rare Entity." Indian Dermatology Online Journal 14, no. 6 (2023): 856–60. http://dx.doi.org/10.4103/idoj.idoj_696_22.

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Vulvar squamous cell carcinoma with sarcomatoid features is an extremely rare histological variant of squamous cell carcinoma with co-existence of both epithelial and mesenchymal features. A 70-year-old woman presented with genital lesions for 4 months with associated burning and pain. Examination revealed well-defined bilaterally symmetrical hyperpigmented plaques on labia majora, fleshy erythematous growth on labia minora. Biopsy from the fleshy mass was suggestive of sarcomatoid malignancy. However, immunohistochemistry was positive for cytokeratin AE1/AE3 and negative for desmin and smooth muscle actin. Biopsy from hyperpigmented plaque was suggestive of Bowens disease. On the basis of histopathology and immunohistochemistry findings, diagnosis of vulvar sarcomatoid squamous cell carcinoma with Bowens disease was made and patient was started on external beam radiation therapy. Sarcomatoid squamous cell carcinoma of vulva is very rare cancer that has an aggressive and fatal course. Diagnosis has traditionally been difficult due to a large ratio of sarcomatous to squamous cell component. Due to its rarity, there are no distinct guidelines to direct therapy and care.

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Milicic, Vesna, Ana Ravic-Nikolic, Bojana Jovovic-Dagovic, Stevan Stojanovic, and Slobodanka Lj Mitrovic. "Generalized Pustular Psoriasis in Association with Squamous Cell Carcinoma of the Hypopharynx." Serbian Journal of Experimental and Clinical Research 18, no. 4 (2017): 361–63. http://dx.doi.org/10.1515/sjecr-2016-0088.

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AbstractPustular psoriasis is an uncommon form of psoriasis consisting of widespread pustules on an erythematous background. Very rarely pustular psoriasis represent a paraneoplastic dermatosis. In this report we describe a case of generalized pustular psoriasis (GPP) associated with advanced, inoperable, metastatic squamous cell carcinoma of the hypopharynx. We suggest that physicians should be alert for the worsening of existing psoriasis or formation of novel psoriasiform eruptions and should undertake clinical evaluation of possible neoplastic disease.

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Kotzerke, Mareike, Fouad Mitri, Alexander Enk, Ferdinand Toberer, and Holger Haenssle. "A Case of Extensive Grover’s Disease in a Patient with a History of Multiple Non-Melanoma Skin Cancers." Case Reports in Dermatology 13, no. 3 (2021): 553–57. http://dx.doi.org/10.1159/000519168.

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We report on a 69-year-old man who presented with itching and erythematous papules on his torso and extremities, which were resistant to topical therapy with antibiotics and steroids. Physical examination revealed multiple erythematous papules on his back, neckline, and lower extremities. The lesions had appeared 4 years earlier and usually worsened with heat or extensive sweating. Histopathology of previous skin biopsies had shown multiple cutaneous squamous cell carcinomas or was non-conclusive. Thus, a re-biopsy was performed, revealing acanthosis and focal acantholytic dyskeratosis. These clinical and anamnestic findings lead to the diagnosis of extensive Grover’s disease (GD). Oral therapy with isotretinoin 30-mg QD led to the regression of the skin lesions. Topical adapalene, as well as topical corticosteroids, were later prescribed for maintenance therapy.

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Lemyaa Es-solh Marhraoui, Fouzia Hali, and Soumiya Chiheb. "Paraneoplastic Acrokeratosis (Bazex Syndrome) associated with pulmonary adenocarcinoma." World Journal of Advanced Research and Reviews 26, no. 2 (2025): 3367–69. https://doi.org/10.30574/wjarr.2025.26.2.1946.

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Bazex paraneoplastic acrokeratosis is a rare dermatosis often preceding the diagnosis of internal malignancies, most commonly squamous cell carcinoma of the upper aerodigestive tract. We report the case of an 82-year-old man with pulmonary adenocarcinoma presenting with erythematous and scaly plaques with palmoplantar keratosis. Clinical and histologic findings supported the diagnosis of Bazex syndrome. This case emphasizes the importance of recognizing paraneoplastic skin signs as potential early indicators of hidden cancers.

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Seok, Joon, Kui Young Park, Kapsok Li, et al. "Squamous Cell Carcinoma and Multiple Bowen's Disease in a Patient with a History of Consumption of Traditional Chinese Herbal Balls." Case Reports in Dermatology 7, no. 2 (2015): 151–55. http://dx.doi.org/10.1159/000437250.

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Arsenic has been classified as a class I human carcinogen, meaning that there is sufficient evidence of carcinogenicity to humans. Arsenic, however, remains a common contaminant in a number of traditional Chinese herbal balls. A 64-year-old man presented with an erythematous erosive patch on the left palm, multiple yellowish scaly patches on the right palm and an erythematous hyperkeratotic patch with bleeding on the left foot dorsum. He also had similar skin lesions on the back and buttock. He had a past medical history of chronic exposure to arsenic through consumption of traditional Chinese herbal balls. Skin biopsy revealed Bowen's disease on the left palm and squamous cell carcinoma on left foot dorsum. We report this case to emphasize that we should investigate patient's history thoroughly, including the use of Chinese herbal balls to find out arsenicism.

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Officer, Kirsty, Mathieu Pruvot, Paul Horwood, et al. "Epidemiology and pathological progression of erythematous lip lesions in captive sun bears (Helarctos malayanus)." PLOS ONE 15, no. 12 (2020): e0243180. http://dx.doi.org/10.1371/journal.pone.0243180.

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This study investigates the occurrence of erythematous lip lesions in a captive sun bear population in Cambodia, including the progression of cheilitis to squamous cell carcinoma, and the presence of Ursid gammaherpesvirus 1. Visual assessment conducted in 2015 and 2016 recorded the prevalence and severity of lesions. Opportunistic sampling for disease testing was conducted on a subset of 39 sun bears, with histopathological examination of lip and tongue biopsies and PCR testing of oral swabs and tissue biopsies collected during health examinations. Lip lesions were similarly prevalent in 2015 (66.0%) and 2016 (68.3%). Degradation of lip lesion severity was seen between 2015 and 2016, and the odds of having lip lesions, having more severe lip lesions, and having lip lesion degradation over time, all increased with age. Cheilitis was found in all lip lesion biopsies, with histological confirmation of squamous cell carcinoma in 64.5% of cases. Single biopsies frequently showed progression from dysplasia to neoplasia. Eighteen of 31 sun bears (58.1%) had at least one sample positive for Ursid gammaherpesvirus 1. The virus was detected in sun bears with and without lip lesions, however due to case selection being strongly biased towards those showing lip lesions it was not possible to test for association between Ursid gammaherpesvirus 1 and lip squamous cell carcinoma. Given gammaherpesviruses can play a role in cancer development under certain conditions in other species, we believe further investigation into Ursid gammaherpesvirus 1 as one of a number of possible co-factors in the progression of lip lesions to squamous cell carcinoma is warranted. This study highlights the progressively neoplastic nature of this lip lesion syndrome in sun bears which has consequences for captive and re-release management. Similarly, the detection of Ursid gammaherpesvirus 1 should be considered in pre-release risk analyses, at least until data is available on the prevalence of the virus in wild sun bears.

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Bakary, Koné Mamadou, Fofana Youssouf, Gassama Mamadou, et al. "Squamous Cell Carcinoma: Excision and Reconstruction with the H-Shaped Flap: About a Case in an Albino." SAS Journal of Surgery 9, no. 03 (2023): 203–6. http://dx.doi.org/10.36347/sasjs.2023.v09i03.013.

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Squamous cell carcinomas are favored by repeated sun exposure, especially in fair-skinned people who easily get sunburned. There are also genetic diseases including albinism which can promote their appearance early in life and multiple forms. We report the first observation of frontal squamous cell carcinoma with resection and reconstruction using the H-shaped flap in an albino (in Mali). Oculo -cutaneous albinism consulted for a frontal ulceration evolving for 3 years. The initial lesion was an erythematous macula which progressively evolved into a dragging ulceration. She had been treated with three sessions of cryotherapy (liquid nitrogen) without success. Physical examination found a slightly crusty ulceration, circumscribed (2 x 1.6 cm), painful and non-itchy. Otherwise the rest of the clinical examination was normal. A biopsy for pathological examination was performed. The diagnosis of invasive squamous cell carcinoma was confirmed. Surgical treatment was performed (resection and reconstruction with the H-shaped flap) with simple postoperative course and satisfactory results from an aesthetic point of view.

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Adhikari, Ram Chandra, Mahesh Shah, and Anjani Kumar Jha. "Histopathological spectrum of skin diseases in a tertiary skin health and referral centre." Journal of Pathology of Nepal 9, no. 1 (2019): 1434–40. http://dx.doi.org/10.3126/jpn.v9i1.23172.

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Background: Skin diseases are very much prevalent in the developing countries. The pattern of skin diseases varies from country to country and even region to region within a country. The histological diagnosis is used by clinicians to aid in the management of patients & most appropriate clinical interventions. Materials and methods: The study included a total of 1040 skin biopsies from January 2016 to December 2018 in the department of pathology, DI skin health and referral centre, Kathmandu, Nepal. Results: The majority of the patients were in the age group of 31-40 years. The most common skin disease is non-infectious vesicobullous and vesicopustular disease (28.6%), followed by non-infectious erythematous papular and squamous disease (25.9%). The most common vesicobullous disease is spongiotic dermatitis (84.8%). Erythema dyschromicum perstans (31.8%) is the commonest non-infectious erythematous papular and squamous disease. The most common microbial disease is fungal infection, followed by leprosy. Among the neoplastic diseases of skin, tumors of epidermis are commonest diseases and the most common epidermal tumor is basal cell carcinoma. The commonest tumor of skin is melanocytic nevus. The most frequent site is upper extremities. Conclusions: Eczema is predominating non-infectious vesicobullous and vesicopustular disease. A relatively higher, prevalence of fungal infections was observed. Basal cell carcinoma is the commonest epidermal tumor and melanocytic nevus is commonest of all skin tumors.

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Szymoniak‑Lipska, Marta, Aleksandra Dańczak‑Pazdrowska, Paweł Pazdrowski, Ryszard Żaba, Zygmunt Adamski, and Adriana Polańska. "he possibility of reactivation of herpes simplex virus as a result of photodynamic therapy — case report." Journal of Face Aesthetics 2, no. 2 (2019): 118–22. http://dx.doi.org/10.20883/jofa.17.

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Actinic keratosis (AK) is a common disorder, presented with scaly, erythematous lesions associated with chronic exposure to ultraviolet (UV) radiation and possible transforming into an invasive squamous cell carcinoma. Photodynamic Therapy (PDT) is one of non-invasive methods of treatment AK. We report the case of a 61-year-old female patient with AK treated with PDT in whom erythema and pustules with concomitant elevated body temperature were observed, what might indicate on reactivation of herpes simplex virus (HSV) infection.

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Ugoh, Gregory Ugoh, Anthony Linfante, Allison Good, Janice Wilson, and Kathleen Kroger. "Bazex Syndrome Associated with Angioimmunoblastic T-cell Lymphoma." SKIN The Journal of Cutaneous Medicine 7, no. 3 (2023): 834–36. http://dx.doi.org/10.25251/skin.7.3.14.

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Bazex syndrome, also known as Acrokeratosis paraneoplastica, is a paraneoplastic disorder characterized by erythematous psoriasiform plaques involving the nose, ears, and acral sites. Although classically associated with squamous cell carcinomas of the upper aerodigestive tract, it has also been reported in association with adenocarcinoma, genitourinary tumors, multiple myeloma, and rarely, peripheral T-cell lymphoma and follicular lymphoma in-situ. Herein, we present a patient with Bazex syndrome associated with angioimmunoblastic T-cell lymphoma (AITL), a rare association not previously reported in the literature.

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Scalvenzi, Massimiliano, Alessia Villani, Caterina Mazzella, Gabriella Fabbrocini, and Claudia Costa. "Cutaneous Bowen’s Disease: an Analysis of 182 Cases according To Age, Sex, and Anatomical Site from an Italian Center." Open Access Macedonian Journal of Medical Sciences 7, no. 4 (2019): 696–97. http://dx.doi.org/10.3889/oamjms.2019.123.

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Bowen's disease (BD), also known as squamous cell carcinoma in situ, is a type of non-melanocytic intraepidermal malignancy characterised by a slowly enlarging erythematous to pink, scaly patch or plaque with irregular and well-demarcated borders. These lesions are usually persistent and progressive; it has been estimated that in general population around 3% to 5% of Bowen's disease transform into invasive squamous cell carcinoma. This report describes our experience with cutaneous BD and assesses the differences found about age, sex and anatomical site. Bowen’s disease was seen more frequently in male patients rather than in female patients in contrast to what confirmed in literature - this difference is probably because being head-neck an exposed region, patients are more easily induced to autoexam and to consult the dermatologist.

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Bharadwaj, Barasha S., Upasana Kalita, Jagannath D. Sharma, et al. "Oral squamous cell carcinoma with clear cell change: a rare case report." International Journal of Research in Medical Sciences 11, no. 7 (2023): 2708–10. http://dx.doi.org/10.18203/2320-6012.ijrms20232127.

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Clear-cell variant of oral squamous cell carcinoma is an extremely rare entity. Clear-cell change can be seen in any of the neoplasms, but as pure form variant, it is difficult to find in head-and-neck SCC. We hereby present a case report of 71-year-old male who presented with a growth with erythematous patches on the lateral pharyngeal wall for the past 3 months. Histopathologic examination showed nests, islands and sheets of malignant squamous cells with vesicular nuclei and abundant clear cytoplasm. Neoplastic cells constituting majority of nests exhibited clear cell changes. Special stain was performed to identify the nature of clear cells. periodic acid Schiff-diastase (PAS-D) showed positivity in the clear cells. Immunohistochemical study using antibody for pan-cytokeratin revealed diffuse positivity in the tumor cells.

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D′ Costa, Grace, and BhavanaM Bharambe. "Spectrum of non-infectious erythematous, papular and squamous lesions of the skin." Indian Journal of Dermatology 55, no. 3 (2010): 225. http://dx.doi.org/10.4103/0019-5154.70666.

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Mufti, Asfandyar, Muskaan Sachdeva, Khalad Maliyar, and R. Gary Sibbald. "Squamous cell carcinoma arising within discoid lupus erythematous lesions: A systematic review." JAAD International 2 (March 2021): 1–4. http://dx.doi.org/10.1016/j.jdin.2020.10.001.

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Sona, Damini, Devendra Kumar Kunjam, Prashant Kumar Gupta, Satyavati Rathiya, and Lowkesh Chandravanshi. "Ayurved for Skin Disorders, A Clinical Success Story of Guttate Psoriasis." International Journal of Ayurvedic Medicine 12, no. 1 (2021): 153–58. http://dx.doi.org/10.47552/ijam.v12i1.1816.

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Psoriasis is a chronic inflammatory papulo-squamous disorder of skin characterized by sharply defined erythematous-squamous lesion varying from pinpoint to large plaque, affecting 1-3% of population worldwide. Psoriasis is well known for its course of remission and exacerbation. Here we report a case of 14-year-oldmale 42 kg weight, rotund physique child, diagnosed as Guttate psoriasis, Guttate psoriasis can be closely correlated with Ekkushtha (one of subtype of Kustha) in Ayurveda. Management of patient with, shodhan therapy (Biological purification of body) like mriduvirechan (Mild laxative) and shaman therapy (conservative therapy) showed remarkable improvement in patient condition. There is appreciable psychological health impairment found in patient, which adversely affect patient quality of life. This case study shows that Ayurveda line of treatment (Shodhan and shaman) gives significant result in the treatment of Guttate psoriasis.

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Achavanuntakul, Petchlada, and Kanchalit Thanomkitti. "Squamous Cell Carcinoma within a Congenital Nevus Sebaceous: Case Report and Literature Review." Case Reports in Dermatology 13, no. 1 (2021): 75–82. http://dx.doi.org/10.1159/000511692.

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Nevus sebaceous (NS) is a benign hamartoma that typically occurs on the head and neck area at birth. Occasionally, secondary neoplasms can develop on top of the original nevus, which usually occur in the middle age. Squamous cell carcinoma (SCC) arising in NS may occur but is very rare. We report the case of a 44-year-old female with an asymptomatic erythematous papule arising within a hairless yellowish plaque on the left parietal area of her scalp for a month. An excisional biopsy was done, and the histopathologic examination revealed SCC arising in the NS.

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Banti, Sudha, Sneha V N, Abishek Muniraju Reddy, Rajesh G, and Srinivas Konappalli. "Verrucous Bowen\\\'s disease: A case report of an unusual variant." IP Indian Journal of Clinical and Experimental Dermatology 10, no. 3 (2024): 353–56. http://dx.doi.org/10.18231/j.ijced.2024.062.

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Squamous cell carcinoma in situ, often known as Bowen's disease, is a type of intraepidermal carcinoma that is most frequently observed in the older population in places that are particularly exposed to the sun. The advancement of this neoplasm to invasive squamous cell carcinoma (SCC) occurs in fewer than five percent of instances, and it is often the case that it is indolent. An erythematous, crusty, and scaly plaque is the typical manifestation of Bowen's disease. However, reports have documented other rare presentations, including pigmented, atrophic, hypertrophic, or verrucous lesions. We present a case of a 72-year-old female patient who, over a period of four years, presented with a progressively increasing tumor on her left buttock. The clinical examination revealed a hyperkeratotic plaque that was well-defined, raised, verrucous, and crusted. The plaque measured 8 x 10 cm. The histopathological examination revealed a diagnosis of Bowen's disease, which was developing into squamous cell carcinoma. The plastic surgeon carried out a wide local excision, followed by full-thickness skin grafting. We hereby are reporting this case for its unusual presentation in a sun-protected area, its rapid progression to squamous cell carcinoma with no evidence of immunosuppression, and how early diagnosis, timely invasion, and treatment play a key role in avoiding metastasis.

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Lana, SE, GK Ogilvie, SJ Withrow, RC Straw, and KS Rogers. "Feline cutaneous squamous cell carcinoma of the nasal planum and the pinnae: 61 cases." Journal of the American Animal Hospital Association 33, no. 4 (1997): 329–32. http://dx.doi.org/10.5326/15473317-33-4-329.

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Cutaneous squamous cell carcinoma is a common tumor in cats and frequently occurs on the nasal planum and the pinnae. The medical records of 61 cats were reviewed for this retrospective study. Typical presentation was an older (median age, 12 years) cat with an erythematous, crusty, and erosive lesion. Methods of treatment included surgery, radiation, and cryotherapy. Disease-free interval and survival time were calculated for each case and grouped according to lesion location and treatment type. All treatments were found to be effective, with surgery resulting in the longest disease-free interval (median, 594 days).

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Quinn, Adam M., Anna Sienko, Zane Basrawala, and Steve C. Campbell. "Extramammary Paget Disease of the Scrotum With Features of Bowen Disease." Archives of Pathology & Laboratory Medicine 128, no. 1 (2004): 84–86. http://dx.doi.org/10.5858/2004-128-84-epdots.

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Abstract The scrotum is an uncommon site for the presentation of extramammary Paget disease (EMPD). We describe a case of EMPD that was discovered in a patient who had been previously diagnosed and treated for squamous cell carcinoma in situ of the scrotum 3 years earlier. Pathologic examination of the current scrotectomy specimen revealed an erythematous patch with areas of pale induration. Microscopic examination revealed areas with the characteristic histology of Paget disease adjacent to areas characteristic of Bowen disease. Immunohistochemical findings demonstrated a strong expression of carcinoembryonic antigen, cytokeratin 7, and low-molecular-weight cytokeratins (CAM 5.2) in both of these areas, giving support to the overall diagnosis of EMPD. High-molecular-weight cytokeratins (34βE12) were uncharacteristically expressed in the cytoplasm of the Paget cells with equal or greater strength than in the surrounding keratinocytes, suggesting some degree of squamous differentiation. Very few publications have reported the coexistence of EMPD with squamous cell carcinoma in situ, occurring mostly in the vulva. To our knowledge, our case is the first report of scrotal EMPD with features of Bowen disease. Our findings support the theory that primary EMPD arises multifocally from multipotential epidermal cells.

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Parvez, Mashud, Rukon Uddin, and Salahuddin Mahmud. "Histomorphological Study of Skin Lesions in a Specialized Tertiary Care Hospital: A Descriptive Study." Global Academic Journal of Medical Sciences 5, no. 03 (2023): 144–49. http://dx.doi.org/10.36348/gajms.2023.v05i03.004.

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Introduction: The skin is the largest organ of the integumentary system in human. Dermatological lesions are commonly encountered in all countries and it encompasses a wide spectrum, varies from country to country and various regions within a country. Skin diseases are much common in developing countries. The spectrum varies according to geographic distribution, gender, age, and coexisting disorder. We conducted this study to find out the prevalence of different skin lesions and to evaluate their frequency and site of distribution. Aim of the Study: The aim of this study was to find out the prevalence of different skin lesions and to evaluate their frequency and site of distribution. Methods: This was a descriptive study and was conducted in the Department of Histopathology of Bangladesh Specialized Hospital, Dhaka, Bangladesh during the period from January 2019 to December 2021.We included 133 skin biopsies in our study. Result: Among 133 skin biopsies examined, non-infectious vesicobullous and vesicopustular disease were found in 53 (48.18%) cases followed by microbial disease in 20 (18.18%) and non-infectious erythematous papular and squamous disease in 28 (21.05%) cases. Lichen simplex chronicus was the most common vesicobullous disease seen in 08 (15.09%) cases. Dermatophytes were the commonest microbial disease found in 10 (50%) cases. The commonest non- infectious erythematous papular and squamous disease was lichen planus and psoriasis 08 (15.09%) cases. The commonest neoplastic lesion was keratinocytic tumor seen in 13 (56.53%) cases. The commonest tumor of the skin was seborrheic keratosis and squamous cell carcinoma in 13 (56.53 %) cases. Upper extremities were the most frequently involved site by skin lesions. Conclusion: In our study prevalence of lichen simplex chronicus was higher. We observed a wide spectrum of skin lesions ranging from dermatitis to malignant neoplasm. The importance of specific histomorphological features lies in distinguishing various skin lesions and play a major role in making the final diagnosis of these diverse skin lesions. This highlights the role of histopathological examination for the proper management of patient.

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Aromolo, Italo Francesco, Michela Brena, Nicola Adriano Monzani, et al. "A Rapidly Growing Nodule on the Eyebrow of a Pediatric Patient." Dermatopathology 11, no. 4 (2024): 266–71. http://dx.doi.org/10.3390/dermatopathology11040028.

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Abstract: A 11-year-old Caucasian girl presented to our Dermatology Unit with a 2-month history of an erythematous nodule, localized to the medial portion of her left eyebrow, rapidly growing in the two weeks before presentation. The histopathological examination revealed a dermal multi-nodular epithelial neoplasm composed of clear cells, squamous cells, and glandular cells, characterized by cytologic atypia, high mitotic activity, and an infiltrative deep growth pattern. The immunohistochemical profile of the lesion was as follows: CKAE1/AE3+, EMA+, CK8/18+, CK7+, CK19+, AR negative, p63 focally +, Ki67 25%, rare cells GCDFP15+, p53+.

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Khatiwada, Kripa, Jyotsna Rimal, Iccha Kumar Maharjan, Pragya Regmee, Sagar Adhikari, and Shashi Keshwar. "Oral Squamous Cell Carcinoma arising from Lichenoid Contact Reaction: A Case Report." Journal of BP Koirala Institute of Health Sciences 5, no. 2 (2022): 47–51. http://dx.doi.org/10.3126/jbpkihs.v5i2.48550.

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Lichenoid contact reaction is a type of delayed hypersensitivity reaction to constituents derived from dental materials. It may occasionally transform into oral squamous cell carcinoma. A 62-year-male reported with the chief complaint of a wound in the inner aspect of right cheek for 2 weeks. On initial examination, a diffuse erythematous area with interspersed non- scrapable white striae was present on the right buccal mucosa and residual alveolar ridge with respect to 47 extending till gingivobuccal aspect of 45, roughly linear in shape, approximately 3x1 cm2 in size, with a rough overlying surface. Ointment triamcinolone 0.1% was prescribed for 1 week. The patient visited after 3 months. Clinical examination revealed an ulcer with peripheral induration of size approximately 2.5 mm on right buccal mucosa adjacent to 46. An incisional biopsy revealed oral squamous cell carcinoma. Long-term follow-up of patients with oral lichenoid reaction is mandatory for early detection of malignant transformation.

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Trongpisutsak, Ananya, Patou Tantbirojn, and Ruangsak Lertkhachonsuk. "Proportion of vulvar premalignant and malignant lesions in overall vulvar specimens in Thailand." Asian Biomedicine 12, no. 6 (2019): 281–86. http://dx.doi.org/10.1515/abm-2019-0031.

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AbstractBackgroundVulvar lesion is one of the common gynecologic problems.ObjectiveTo assess the proportion of vulvar premalignant and malignant lesions in overall vulvar specimens and to evaluate the clinicopathologic features of each vulvar lesion in King Chulalongkorn Memorial Hospital (KCMH).MethodsPathological microscopic slides and medical records of the patients who underwent vulvar-related operations between January 1, 2002 and December 31, 2015 were reviewed. Patients’ clinical characteristics and pathologic features were evaluated and analyzed.ResultsA total number of 700 patients were included. The proportion of malignant and premalignant lesions in overall vulvar specimens were 16.3% and 8.4%, respectively. Squamous cell carcinoma was the most common malignant vulvar lesion (48.2%), whereas vulvar intraepithelial neoplasia 1 (VIN1) (33.9%) was the most common lesion in the premalignant group. On multivariate analysis, four clinical factors were significantly associated with malignancy risk: increased parity (odds ratio [OR] 1.19, P = 0.010), large tumor size (OR 2.00, P < 0.001), lesion at clitoris (OR 16.67, P = 0.002), and erythematous lesion (OR 2.41, P = 0.026).ConclusionsThe proportion of malignant and premalignant lesions in overall vulvar specimens was 24.7% in KCMH. Increased parity, large tumor size, clitoris-located lesion, and erythematous lesion were associated with increasing malignancy risk.

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Pejnović, Luka, Igor Đurišić, Ognjen Živković, et al. "Penoscrotal Paget's disease: Case report and literature review." Srpski medicinski casopis Lekarske komore 5, no. 4 (2024): 561–66. https://doi.org/10.5937/smclk5-52092.

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Introduction: Penoscrotal Paget's disease is very rare worldwide, with a small number of case reports, and it thus represents a major dilemma in diagnosis and treatment. Case report: An 81-year-old man presents himself to the Institute of Oncology and Radiology of Serbia (IORS) for the first time due to an ulcerated and erythematous tumor change about 10 cm in diameter covered with squamous plates, which extends from the groin region on the left to the scrotum. The tumefaction is erythematous, bloody and it occasionally bleeds, and the patient complains of occasional pain in the left leg. Previously, a biopsy of the mentioned tumor change was performed in another institution, and the PH finding was in favor of extramammary Paget's disease. The patient was presented to the IORS council, which decided on operative treatment. Conclusion: This rare disease is also found outside of clinically visible lesions, positive resection margins are common, and this represents the main risk factor for disease recurrence. Accurate preoperative diagnosis and proper surgical treatment are crucial for preventing relapses and repeat operations, making them key factors in improving survival. This case report certainly represents a significant step for oncologists in understanding this disease.

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Chanyachailert, Pattriya, Penvadee Pattanaprichakul, Sumanas Bunyaratavej, et al. "Evaluation of Clinical Knowledge Regarding Geriatric Skin Conditions among Thai Physicians." Siriraj Medical Journal 75, no. 1 (2023): 1–6. http://dx.doi.org/10.33192/smj.v75i1.260522.

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Objective: Assess the knowledge of common geriatric skin conditions in Thai physicians.Materials and Methods: This retrospective study was conducted among Thai physicians attending annual dermatology courses by the Dermatological Society of Thailand from 2016 to 2019. Data was assessed based on knowledge of diagnosis and management of common geriatric skin conditions.Results: A total of 197 participants, mainly general practitioners, were included. The highest percentage of correct diagnoses were benign erythematous, eczematous lesions (35.5%, senile purpura; 36.0%, xerotic eczema), and malignant diseases (35.5%, basal cell carcinoma; 27.4%, squamous cell carcinoma; 11.7%, subungual melanoma; 24.4%, acral lentiginous melanoma). In contrasts, the lowest percentage of correct diagnosis were premalignant diseases (0.5%, arsenical keratosis; 4.6%, actinic keratosis; 1.0% Bowen’s disease) and benign hypopigmented lesion (0.5%, stellate pseudoscar; 7.6%, idiopathic guttate hypomelanosis). Harmful treatment with systemic antifungal therapy was used in subungual melanoma (58.0%). Harmful management of senile comedone, subungual melanoma and acral lentiginous melanoma was significantly found in physicians given the incorrect diagnosis. (p = 0.027, p <0.001, p = 0.014, respectively).Conclusion: Most physicians recognized malignant lesions, benign erythematous or eczematous diseases in elderly skin. Surprisingly, almost all physicians couldn’t diagnose premalignant lesions and benign hypopigmented lesions.

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Agrawal, Sonal, K. B. Mishra, and C. M. Gupta. "Histopathological spectrum of non-infectious erythematous, papulo-squamous lesions: at a teritary care institute." International Journal of Research in Medical Sciences 6, no. 6 (2018): 2072. http://dx.doi.org/10.18203/2320-6012.ijrms20182291.

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Background: Dermatologic disorders are common in many countries, but the spectrum varies greatly. Papulosquamous lesions of the skin are encountered with considerable frequency. There is overlap of both clinical pattern and distribution of papulosquamous skin disorders, which often makes clinical diagnosis difficult, Histopathology is highly specific and sensitive for many lesions and its remains the gold standard for most dermatological diagnosis.Methods: A prospective histopathological study of 50 cases, which was carried out in the department of dermatology and Pathology in L. N. medical college and J. K. hospital research center, over a period of 1 year. A brief history and dermatological examination was carried out, skin biopsies taken were fixed in 10% formalin and subjected for tissue processing. Followed by microscopic examination.Results: In the present study of 50 cases of papulosquamous disorders psoriasis 60% (30 Cases) was the commonest followed by lichen planus 20% (10 cases), 3% (6 cases) each of pityriasis rubra, pilaris, parapsoriasis, Pityriasis rosea, and 4% (02 cases) of seborrheic dermatitis. Commonest age-group 31-40 years was more affected, sex distribution pattern revealed a male preponderence. 30 cases showed compatible clinical as well as histopathological diagnosis.Conclusions: Key histopathological features and clinico-pathological study gives a conclusive diagnosis. The importance of specific histo-morphological diagnosis lies in the distinguishing various lesions and their prognosis.

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Sharma, Poonam, Ritu Bhagat, and Surbhi Mahajan. "Histopathological Evaluation of Non-infectious Erythematous Papulo-squamous Skin Lesions in North-West India." Saudi Journal of Pathology and Microbiology 5, no. 9 (2020): 395–98. http://dx.doi.org/10.36348/sjpm.2020.v05i09.001.

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Lima, Celina Faig, Renata Acay, Ana Lia Anbinder, Janete Dias Almeida, and Yasmin Rodarte Carvalho. "Oral Adenosquamous Carcinoma Mimicking a Pyogenic Granuloma: a Challenging Diagnosis." Brazilian Dental Journal 27, no. 6 (2016): 781–86. http://dx.doi.org/10.1590/0103-6440201600957.

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Abstract Adenosquamous carcinoma is an aggressive variant of squamous cell carcinoma. This report describes a case of adenosquamous carcinoma with clinical features of a benign lesion and discusses the differential diagnoses, especially regarding histopathological and immunohistochemical analyses. A 45-year-old male was referred to our outpatient clinic complaining about a rapid-growing enlargement in hard palate. Clinical examination revealed an erythematous and pedunculated nodule with lobulated non-ulcerated surface. Excisional biopsy was performed following clinical diagnosis of pyogenic granuloma. Histologically, the specimen consisted of areas characterizing both well-differentiated squamous cell carcinoma and true adenocarcinoma. After a broad list of immunohistochemical markers was evaluated (AE1/AE3, CEA, CK5, CK7, CK8/18, p53, p63 and Ki67), the diagnosis of adenosquamous carcinoma was rendered and the patient referred to complementary surgery. Adenosquamous carcinoma represents a challenge in diagnostic routine due to its rarity, diverse range of clinical presentations and histological features. Furthermore, classical clinical benign features may be present in malignant lesions; hence the submission of every surgical specimen to histological analysis is mandatory to provide the patient the adequate treatment.

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Sudhana M, Madhu, Sannidhi Sara S, Vathsala S, Megha M. Shrikantaiah, and Somashekar YB. "Verrucous lesion mimics- A case series." IP Indian Journal of Clinical and Experimental Dermatology 9, no. 4 (2024): 240–43. http://dx.doi.org/10.18231/j.ijced.2023.046.

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Cutaneous lesions with wart like growth pattern are referred as verrucous lesions. Few lesions clinically look like warts but they are associated with different conditions, pathology, prognosis and treatment. Histopathology plays a very important role in such cases to diagnose the condition. In this article we present 5 different cases, with verrucous morphology. Our first case was a 70 year old man, with verrucous growth over hyperpigmented plaque on left leg. Biopsy showed Squamous cell Carcinoma overlying Lichen Simplex Chronicus. Second case was a 65yr old man with verrucous growth over right thigh diagnosed as well differentiated Squamous cell carcinoma on histopathology. Third case was a 22year old man, with multiple erythematous verroucous growth over left thigh. Biopsy showed syringocystadenoma papilliferum. Fourth case was a 9 year old female, with verrucous lesion over left side of forehead. Biopsy suggested chondroid syringoma. Fifth case was a 25year old female with multiple verrucous lesions over nose, diagnosed as sebaceous hyperplasia. Difficulty in diagnosing verrucous lesions can be resolved with knowledge and awareness of different diseases with verrucous morphology and histopathological examination.

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Caca-Biljanovska, Nina, Irina Arsovska-Bezhoska, and Marija V’lckova-Laskoska. "Giant Bowen’s Disease on the Face: Case Report and Review of the Literature." Open Access Macedonian Journal of Medical Sciences 7, no. 4 (2019): 606–9. http://dx.doi.org/10.3889/oamjms.2019.190.

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BACKGROUND: Giant Bowen’s disease is a rare and unusual clinical manifestation. Presenting as extensive scaly erythematous patch or plaque, it gives rise to a wide spectrum of dermatological differential diagnoses. CASE PRESENTATION: We report a patient with giant Bowen’s disease on the face that was successfully treated with topical 5 % imiquimod. A review of the literature was made with the aim to analyse and compare the findings in it with our observation. CONCLUSION: We present this case to draw attention to the importance of the self skin examination in the elderly population. Also, to prevent development to invasive squamous cell carcinoma from Bowen’s disease, we recommend mandatory dermoscopic examination on every long-standing erythemosquamous lesion.

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Bakalielkhalil, El, Keby Edgar, Kerrouch Hasna, et al. "PEMPHIGUS HERPETIFORMIS TREATED EFFECTIVELY WITH DERMOCORTICOIDS ALONE." International Journal of Advanced Research 12, no. 05 (2024): 727–31. http://dx.doi.org/10.21474/ijar01/18777.

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Introduction: Pemphigus herpetiformis is a rare form of pemphigus. Case Report: A patient presented with a well-limited erythematous-squamous and crusty dermatosis with a ring-like arrangement, with vesiculo-bullous lesions with a herpetiform grouping of the trunk and 4 limbs. Histological and direct immunofluorescence findings were consistent with pemphigus. The diagnosis of pemphigus herpetiformis (PH) was made. The patient was treated with dermocorticoids with lasting remission. Discussion: Pemphigus herpetiformis is a particular form of pemphigus characterised by a clinical picture resembling that of dermatitis herpetiformis and an immunopathological appearance similar to that of pemphigus. It generally has a good prognosis. Treatment is based on dapsone and/or general corticosteroid therapy.

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Görürgöz, Cansu, Nilsu Sakalli, Ferah Mutlu Kul, and Nurhan Uslu Özalp. "Ultrasonographic Evaluation of Maxillofacial Swelling in a Pediatric Patient with Xeroderma Pigmentosum." Balkan Journal of Dental Medicine 23, no. 3 (2019): 163–66. http://dx.doi.org/10.2478/bjdm-2019-0029.

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Summary Background/Aim: Xeroderma pigmentosum (XP) is an autosomal recessive skin disease. Affected patients have skin problems, oral mucosa and neurologic symptoms. In these patients, erythematous, hyperpigmented or malignant skin lesions may occur in the sun-exposed areas. Leukoplakia, erythroplakia, and squamous cell carcinoma of the tip of the tongue and lips are common oral lesions associated with XP. Case report: Treatment of the disease included protection from ultraviolet radiation, topical application to treat actinic keratitis, and multidisciplinary approaches by physicians. Conclusions: Even though USG in dentistry is not very common, it is a non-invasive, cost-effective, readily available and repeatable diagnostic imaging method. Thus, USG should take place as a routine diagnostic tool in dentistry, especially for patients who are medically compromised.

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Orlov, E. V., P. YE Konnov, and S. I. Chaplygina. "Role of modern topical steroids in treatment of atopic dermatitis in children." Vestnik dermatologii i venerologii 88, no. 2 (2012): 55–58. http://dx.doi.org/10.25208/vdv668.

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Atopic dermatitis is a widespread problem, and its treatment is a complicated problem for clinicians. The efficacy, safety, cost and complexity of therapeutic measures are the Key components for treatment compliance and ultimately define the success of treatment. The article presents the results of a prospective open-label study of the clinical efficacy of the application of mometasone furoate (Elocom) for atopic dermatitis in children with the exudative and erythematous squamous forms with initial signs of lichenification and its effect on the IDLQI (Infant's Dermatological Life Quality Index). It was established that the application of Elocom vs. the hydrocortisone cream and ointment (in case of the exudative form) contributed to the faster reduction of the intensity of clinical manifestations of atopic dermatitis.

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Gancheva, Rada, Joana Pozharashka, Atanas Koundurdjiev, Milena Nikolova-Vlahova, Petya Yankova, and Liubomir Marinchev. "A clinical case of pityriasis lichenoides chronica presenting with palpable purpura after streptococcal infection." Folia Medica 66, no. 3 (2024): 426–30. http://dx.doi.org/10.3897/folmed.66.e111548.

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Pityriasis lichenoides is a rare inflammatory skin condition presenting with diffuse red-brown papules with evolution polymorphism and mica-like crust on older skin lesions. We present a 60-year-old female patient with pityriasis lichenoides chronica that manifested ten days after streptococcal pharyngitis. Initially, palpable purpura appeared on the lower extremities and later, erythematous-squamous papules and plaques appeared at the site of the palpable purpura and on the upper limbs and trunk. The patient had no history of hematological malignancy, viral hepatitis, kidney involvement, systemic rheumatic disease, or ANCA-associated vasculitis. After administration of methylprednisolone 20 mg for one month and an antimalarial agent (hydroxychloroquine 200 mg, 1 tablet bid) for three months, the skin lesions subsided without recurrence.

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