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Dissertations / Theses on the topic 'ESBL Extended spectrum of Beta Lactamase'

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Published: 4 June 2025

Last updated: 15 July 2025

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1

Pettersson, Linda, and Ida Axelsson. "Sjuksköterskestudenters kunskaper om Methicillinresistent Staphylokock aureus (MRSA), Extended Spectrum Beta-Lactamase (ESBL) och basala hygienrutiner." Thesis, University of Gävle, Ämnesavdelningen för vårdvetenskap, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-5616.

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<p>Syftet med studien var att beskriva och jämföra vilka kunskaper sjuksköterskestudenter i slutet av utbildningen vid två lärosäten har gällande Methicillinresistent Staphylokock aureus (MRSA), Extended Spectrum Beta-Lactamase (ESBL) och basala hygienrutiner. Vidare var syftet att beskriva sjuksköterskestuderandes uppfattningar av utbildningens kvalitet gällande MRSA, ESBL och hygienrutiner. Studien hade en beskrivande och jämförande design. Undersökningsgruppen valdes ut genom bekvämlighetsurval. Data samlades in med ett frågeformulär som besvarades av 126 sjuksköterskestudenter.</p><p>Resul

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Domingos, Daniela Ferreira 1984. "Detecção e identificação de beta-lactamase de espectro-estendido (ESBL) em cepas de Escherichia coli isoladas de cães." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316678.

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Orientador: Domingos da Silva Leite<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-16T00:21:34Z (GMT). No. of bitstreams: 1 Domingos_DanielaFerreira_M.pdf: 1627311 bytes, checksum: ba7a6545a75d72a741bfe8d1cda234f4 (MD5) Previous issue date: 2010<br>Resumo: O número de animais de companhia tem crescido substancialmente na sociedade atual, com estimativas de 48 milhões de cães e gatos no Brasil. A relação entre animais de companhia e os humanos mudou radicalmente nos últimos anos, esses estão em contato mais próximo c

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Lytsy, Birgitta. "Enterobacteriaceae Producing Extended-Spectrum Beta-Lactamases : Aspects of Detection, Epidemiology and Control." Doctoral thesis, Uppsala universitet, Klinisk bakteriologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131901.

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Enterobacteriaceae belong to the normal enteric flora in humans and may cause infections. Escherichia coli is the leading urinary tract pathogen with septicaemic potential, whereas Klebsiella pneumoniae causes opportunistic infections and often outbreaks in hospital settings. Beta-lactams are the first choice for treatment of infections caused by Enterobacteriaceae, and might be destroyed by extended-spectrum beta-lactamases, ESBLs. ESBLs hydrolyse all beta-lactams except cephamycin and carbapenems, and constitute a large heterogeneous group of enzymes with different origins. The phenotypic an

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Khanfar, Husam. "Molecular epidemiological study of extended spectrum beta-lactamase (ESBL) producing bacteria from a hospital within Saudi Arabia." Thesis, University of Portsmouth, 2017. https://researchportal.port.ac.uk/portal/en/theses/molecular-epidemiological-study-of-extended-spectrum-betalactamase-esbl-producing-bacteria-from-a-hospital-within-saudi-arabia(160a04ec-896c-46c0-8390-8c076a5f7da3).html.

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Extended spectrum beta-lactamase (ESBL) producing bacteria are the cause of widespread infections worldwide, in both hospital and community settings. The presence of ESBLs prevent treatment of the infection with many β-lactam antibiotics. Highly mobile genetic element such as plasmids carrying ESBL genes often also harbour resistance genes to other classes of antimicrobials. To date, susceptibility generally remains high to the carbapenem antibiotics and to the polymyxin colistin and the glycylcycline tigecycline. However rigorous antibiotic stewardship programmes on national and international

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Yuan, Meifang. "Molecular epidemiology of klebsiellae with extended-spectrum #beta#-lactamases and multiple drug resistances." Thesis, Queen Mary, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325544.

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Rodrigues, Lilian de Oliveira [UNESP]. "Detecção de beta-lactamase de espectro estendido em membros da família Enterobateriaceae." Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/86619.

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Made available in DSpace on 2014-06-11T19:22:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-08-15Bitstream added on 2014-06-13T18:48:56Z : No. of bitstreams: 1 rodrigues_lo_me_arafcf.pdf: 364674 bytes, checksum: 25ad80987f7d2eb4d8bf537154a09922 (MD5)<br>Universidade Estadual Paulista (UNESP)<br>A produção de beta-lactamase de espectro estendido (ESBL) em membros da família Enterobacteriaceae pode conferir resistência a cefalosporinas de amploespectro, aztreonam e penicilinas. Devido a esse fenômeno, a detecção exata dos produtores de ESBL é essencial para a seleção apropriada da a

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Gürntke, Stephan [Verfasser]. "Bakteriämie mit Extended- Spectrum- Beta- Lactamase (ESBL)-positiven K. pneumoniae : Epidemiologie, molekulare Epidemiologie, Risikofaktoren für Krankenhausletalität und Zusatzkosten bei Infektion / Stephan Gürntke." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1119802938/34.

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Kareivienė, Sandra. "Laboratorinės diagnostikos metodų, nustatančių Enterobacteriaceae šeimos plataus veikimo β-laktamazių fenotipą, palyginimas bei šių fermentų paplitimo analizė Vilniaus universiteto ligoninės Santariškių klinikose 2008 - 2010 metais." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2011~D_20140627_165923-15581.

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Šio tyrimo tikslas palyginti diskų difuzijos ir automatizuotą metodus, nustatančius Enterobacteriaceae šeimos bakterijų plataus veikimo β-laktamazių (PVBLazių) fenotipą ir įvertinti PVBLazių paplitimą Vilniaus universiteto ligoninės Santariškių klinikose 2008-2010 metais. Tyrimų analizei buvo pasirinkta 58 Enterobacteriaceae šeimos bakterijos, išskirtos 2009-2011 metais ligoniams, besigydžiusiems Vilniaus Universiteto ligoninės Santariškių klinikose. Bakterijos ištirtos naudojant fenotipinius PVBL nustatymo metodus: automatizuotą Phoenix sistemą (Becton Dickenson, Sparks, MD, JAV), kombin

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Dzafic, Sara. "Genotypisk bestämning av ESBL-producerande E. coli isolerade i Kronobergs län 2009." Thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-8299.

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Vanlig tarmbakterie som Escherichia coli (E. coli) kan bland annat orsaka infektioner i bukhålan och urinvägsinfektioner. Infektioner orsakade av bakterien har ofta behandlats med betalaktamantibiotika, som penicilliner och cefalosporiner, vilket har resulterat i selektion av antibiotikaresistenta bakterier. Extended-Spectrum Beta-Lactamases (ESBL) är enzymer som hydrolyserar 3:e generationens cefalosporiner som cefotaxim, ceftazidim och ceftriaxon, men kan även bryta ner penicilliner, monobaktamer och övriga cefalosporiner. ESBL förekommer främst hos E. coli och Klebsiella pneumoniae. I börja

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Hasan, Badrul. "Antimicrobial Resistance and Production of Extended Spectrum Beta-Lactamases in Enterobacteriaceae from Birds in Bangladesh." Doctoral thesis, Uppsala universitet, Klinisk mikrobiologi och infektionsmedicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199686.

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The dissemination of members of the Enterobacteriaceae family with extended spectrum beta-lactamases (ESBLs) and metallo-beta-lactamases (MBLs) has become a global concern. ESBLs and MBLs have been reported in humans, domestic animals, wildlife and the environment, and their isolation frequencies are increasing rapidly worldwide. Most studies have been performed in developed countries and quite few in developing countries, where the antibiotic consumption is often poorly controlled. To explore the environmental contamination of antibiotic resistance in Bangladesh, and of ESBLs and MBLs in par

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Ahmed, Aden. "Utveckling av en PCR-baserad metod för detektion av plasmidburna kolistinresistens, mcr-1 och mcr-3 gener i extended-spectrum beta-lactamase (ESBL)-producerande enterobacteriaceae." Thesis, Högskolan Kristianstad, Sektionen för lärande och miljö, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-17928.

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Kolistin är ett gammalt polypeptidantibiotikum och används som sista utväg för behandling av allvarliga infektioner orsakad av multiresistenta gramnegativa bakterier. Nya studier har påvisat kolistinresistensgener, mcr (mobil colistin resistance), hos extended spectrum beta-lactamase (ESBL)-producerande Enterobacteriaceae. Mcr-genen ligger i plasmider som kan överföras mellan bakterier, vilket innebär att det är mycket svårare att behandla människor och djur vid infektion orsakad av patogen som erhållit denna resistens. Syfte med detta projekt var att utveckla en PCR-baserad metod för detektio

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Lussier, Pamela, та University of Lethbridge Faculty of Arts and Science. "Characterization of putative extended-spectrum β-lactamases (ESBL) producing Escherichia coli isolated from feedlot cattle in Southern Alberta". Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Science, 2010, 2010. http://hdl.handle.net/10133/2563.

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This thesis describes the detection, and characterization of putative extended-spectrum β-lactamases (ESBLs) producing Escherichia coli isolated from feedlot cattle in southern Alberta. Cattle either received no antimicrobials or were administered subtherapeutic antimicrobials in feed. In total, 7,184 E. coli isolates were collected, and screened for resistance to either ceftazidime (2μg mL-1 ) or cefpodoxime (2μg mL-1), and from these results 237 E. coli isolates were considered presumptive ESBL producers. Antimicrobial resistant bacteria were isolated throughout the experiment; however, ESBL

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Hammond, David Scott. "SHV β-lactamases : DNA diagnostics and evolution". Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16194/1/David_Hammond_Thesis.pdf.

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TEM and SHV β-lactamases are the most prevalent β-lactamases among Gram-negative bacteria. The introduction and widespread use of expanded-spectrum antibiotics, particularly third generation cephalosporins, has led to the evolution of bacterial strains expressing extended spectrum β-lactamases (ESBLs). ESBLs emerge by genetic point mutation from non-extended spectrum precursors. It was found that multiple β-lactamase families within single isolates complicate the process of detecting the resistance status of isolate using non-quantitative DNA diagnostic methods. Preliminary phenotypic chara

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Hammond, David Scott. "SHV β-lactamases : DNA diagnostics and evolution". Queensland University of Technology, 2006. http://eprints.qut.edu.au/16194/.

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TEM and SHV β-lactamases are the most prevalent β-lactamases among Gram-negative bacteria. The introduction and widespread use of expanded-spectrum antibiotics, particularly third generation cephalosporins, has led to the evolution of bacterial strains expressing extended spectrum β-lactamases (ESBLs). ESBLs emerge by genetic point mutation from non-extended spectrum precursors. It was found that multiple β-lactamase families within single isolates complicate the process of detecting the resistance status of isolate using non-quantitative DNA diagnostic methods. Preliminary phenotypic charact

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Gerhofer, Carolin [Verfasser], and Rüdiger [Akademischer Betreuer] Korbel. "Vorkommen und Bedeutung von Antibiotikaresistenzen und Extended-Spectrum Beta-Lactamasen (ESBL) bei Escherichia coli aus Wildvögeln mit Kontakt zu Menschen aus Südbayern / Carolin Gerhofer. Betreuer: Rüdiger Korbel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1076243223/34.

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Maataoui, Naouale. "Acquisition et transmission d'entérobactéries productrices de BLSE chez des sujets communautaires en zone de forte endémie." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCC087.

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Le portage et les infections à entérobactéries productrices de bêta-lactamase à spectre étendu (E-BLSE) touchent de plus en plus fréquemment les sujets communautaires. La prévalence de portage dans la communauté a été estimée à 30 et 70% respectivement en Afrique et en Asie alors qu’elle n’est que de 10% en Europe. Le fait de vivre ou de séjourner dans des zones de forte endémie constitue donc un facteur de risque élevé d’acquisition d’E-BLSE. La prévalence du portage d’entérobactéries résistantes dans les zones intertropicales et les facteurs de risque d’acquisition par un sujet individuel lo

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Apostolakos, Ilias. "Bacterial resistance to third-generation cephalosporins and colistin in the poultry industry." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3425776.

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Antimicrobial resistance is one of the major public health threats that humans face with a significant number of annual deaths and economic losses from associated sequelae. Presence of resistance determinants in food-producing animals represents an important exposure risk since they can be transmitted to humans by direct contact or via the food chain. Among the various types of resistance already described in poultry, resistance to critically important antimicrobials, such as third-generation cephalosporins (3GCs) and colistin, is worrying due to the crucial role of these antimicrobials in sev

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Dropa, Milena. "Caracterização genotípica de cepas da família enterobacteriaceae produtoras de ß-lactamases de espectro estendido, isoladas de pacientes de um hospital da rede pública da cidade de São Paulo." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/6/6135/tde-12022007-141647/.

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Introdução - A crescente resistência antimicrobiana em bactérias responsáveis por infecções hospitalares é um grande desafio à Saúde Pública. as B-lactamases de espectro estendido (ESBL), que hidrolisam a maioria dos compostos B-lactâmicos, são reconhecidas mundialmente como um grande problema para pacientes hospitalizados, devido à localização de seus genes em elementos transferíveis, facilitando sua disseminação. Objetivo - Caracterizar geneticamente cepas de Enterobactérias produtoras de ESBL isoladas de pacientes de um hospital público da cidade de São Paulo. Material e métodos - Todas as

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Distelmaier, Laura Eva Valentine. "Extended-Spectrum-Beta-Laktamasen : ESBL-bildende Bakterien im Bonner Raum /." Bonn, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253860.

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Ferreira, Helena Cardoso de Carvalho. "Antibioresistance of Extended-Spectrum β-Lactamase producer Enterobacteriaceae strains from broiler samples". Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2008. http://hdl.handle.net/10400.5/878.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>O objectivo deste estudo foi determinar em que medida a higiene do matadouro influenciava a produção de β-lactamases de espectro alargado (ESBL’s) em Salmonella e outras Enterobacteriaceae. Para tal, foram colhidas amostras em vários pontos da linha de abate de frangos de engorda (“broiler”) num matadouro na Holanda. A partir dos dados recolhidos quantificou-se o número de Enterobacteriaceae e isolou-se Salmonella spp.. Testou-se a resistência aos seguintes antibióticos: ampicillina, ceftiofur, trimethoprim+sulfametoxazol, eritromici

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Jones, Caron. "Molecular epidemiology of extended-spectrum β-lactamase (ESBL) carrying Enterobacteriaceae at ABM University Health Board". Thesis, Swansea University, 2012. https://cronfa.swan.ac.uk/Record/cronfa42241.

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Extended-spectrum beta-lactamases (ESBL) mediate resistance to 3rd generation cephalosporins and aztreonam in Enterobacteriaceae and pose major clinical problems. Screened Enterobacteriaceae were collected from PHW Microbiology ABM Swansea laboratory and were demonstrated phenotypically to be ESBL- producers by BSAC methods. Isolates were identified using the BD Phoenix Automated system and Bruker Daltonics MALDI Biotyper. 138 isolates were genetically defined as ESBL-producers (103 Escherichia coli, 32 Klebsiella spp., 2 Enterobacter cloacae and 1 Citrobacter freundii) and 4 isolates (2 E. co

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Paterson, David L. "Extended-spectrum beta-lactamase producing bacteria : epidemioloyg, characterisation, detection and treatment /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe.pdf.

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Svärd, Louise. "Evaluation of phenotypic and genotypic extended-spectrum beta-lactamase detection methods." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8021.

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<p>The emergence and spread of resistance in Enterobacteriaceae is a growing concern in human medicine today. Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs) have become efficient at inactivating β-lactam antibiotics especially the newer third generation cephalosporins. In addition, ESBL producing Enterobacteriaceae are frequently resistant to other groups of commonly used non-β-lactam antibiotics such as the fluoroquinolones. Reliable, rapid and low cost methods to detect ESBLs in clinical microbiology laboratories are therefore required.</p><p>The aim of this project was

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Svensson, Ida. "Jämförelse och utvärdering av tre kromogena medier för detektion av Extended-spectrum β-lactamase hos Enterobacteriaceae". Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-55112.

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Kliniska användandet av antibiotika är under ett allt större hot då bakterier har utvecklat resistens mot många klasser av antibiotika som används i sjukvården. Resistensgener hos bakterier finns kromosomalt eller burna av plasmider som kan förvärvas från andra bakterier. Spridning av resistens mot β-laktamantibiotika är oroande hos Enterobacteriaceae där inte många antibiotikaalternativ finns. Några plasmidburna β-laktamaser med ett utökat spektrum (ESBL) har blivit vanligare. Syftet med studien var jämförelse och utvärdering av tre kommersiella kromogena medier (CHROMagar™ C3GR, Chromatic™ E

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Östholm, Balkhed Åse. "Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae : Antibiotic consumption, Detection and Resistance Epidemiology." Doctoral thesis, Linköpings universitet, Avdelningen för mikrobiologi och molekylär medicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104216.

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ESBL-producing Enterobacteriaceae are emerging worldwide and they are frequently multi-drug resistant, thus limiting treatment options for infections caused by these pathogens. The overall aim of the thesis was to investigate ESBL-producing Enterobacteriaceae in a Swedish county. First, we developed a molecular method, a multiplex PCR assay for identification of SHV, TEM and CTX-M genes in clinical isolates of Enterobacteriaceae with an ESBL phenotype. From 2002 until the end of 2007 all isolates of ESBL-producing Enterobacteriaceae in Östergötland, Sweden were further investigated. The preval

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NABESHIMA, TOSHITAKA, AKIHIRO MOURI, TAKENAO KOSEKI, HIDEKI NISHIYAMA, TAKAYOSHI MAMIYA та YOSHIAKI IKEDA. "RISK FACTORS FOR EXTENDED-SPECTRUM β-LACTAMASEPRODUCING ESCHERICHIA COLI INFECTION IN HOSPITALIZED PATIENTS". Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16027.

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Dakh, Farshid. "Mutation frequency of non-ESBL phenotype SENTRY (Asia-Pacific) isolates of Klebsiella pneumoniae conversion to an ESBL positive phenotype." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/28413/1/Farshid_Dakh%27s_Thesis.pdf.

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Extended spectrum β-lactamases or ESBLs, which are derived from non-ESBL precursors by point mutation of β-lactamase genes (bla), are spreading rapidly all over the world and have caused considerable problems in the treatment of infections caused by bacteria which harbour them. The mechanism of this resistance is not fully understood and a better understanding of these mechanisms might significantly impact on choosing proper diagnostic and treatment strategies. Previous work on SHV β-lactamase gene, blaSHV, has shown that only Klebsiella pneumoniae strains which contain plasmid-borne blaSHV ar

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Dakh, Farshid. "Mutation frequency of non-ESBL phenotype SENTRY (Asia-Pacific) isolates of Klebsiella pneumoniae conversion to an ESBL positive phenotype." Queensland University of Technology, 2008. http://eprints.qut.edu.au/28413/.

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Extended spectrum β-lactamases or ESBLs, which are derived from non-ESBL precursors by point mutation of β-lactamase genes (bla), are spreading rapidly all over the world and have caused considerable problems in the treatment of infections caused by bacteria which harbour them. The mechanism of this resistance is not fully understood and a better understanding of these mechanisms might significantly impact on choosing proper diagnostic and treatment strategies. Previous work on SHV β-lactamase gene, blaSHV, has shown that only Klebsiella pneumoniae strains which contain plasmid-borne blaSHV ar

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Tärnberg, Maria. "Extended-spectrum beta-lactamase producing Enterobacteriaceae : aspects on detection, epidemiology and multi-drug resistance." Doctoral thesis, Linköpings universitet, Klinisk mikrobiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76134.

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Beta-lactam antibiotics are the largest and most commonly used group of antimicrobial agents in Sweden as well as world-wide. They show very good tolerability and many of the drugs can be administrated orally. Bacteria expressing extended-spectrum beta-lactamases (ESBLs), enzymes hydrolysing penicillins and cephalosporins, may not respond to therapy using some of these antibiotics. The isolates are also often co-resistant to other antimicrobial agents, thus further limiting treatment options. Often parenterally administrated carbapenems is one of few safe treatment options left. In this thesis

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Ensor, V. M. "the molecular epidemiology and genetic mobility of the blaCTX-M extended spectrum beta-lactamase genes." Thesis, University of Birmingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.743413.

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Jade, Mohamed$cEl [Verfasser]. "Diagnostik von Extended Spectrum Beta-Lactamase-bildenden Enterobakterien in Tier und Mensch / Mohamed El Jade." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1139118692/34.

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Ghosh, Hiren [Verfasser]. "A genome-based approach to study the ecology and epidemiology of Extended-Spectrum Beta-Lactamases (ESBLs) producing E. coli / Hiren Ghosh." Gießen : Universitätsbibliothek, 2019. http://d-nb.info/1186624604/34.

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Ibrahim, Delveen. "Phenotypic and genotypic study of multidrug resistant, extended spectrum β-lactamase (ESBL)-producing Escherichia coli isolated from a dairy farm". Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/46613/.

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Approximately 400 tonnes of antibiotics (including synthetic antibiotics) are used every year in treating infections in farm animals, and as prophylactics against infection. Antimicrobial resistance is a crucial problem that is now of great concern in public health, with food and food producing animals as a potential route for spread of these resistances, especially resistance to cephalosporins, which is increasing. The main aim of this study was to determine the prevalence and range of multidrug resistance (MDR) and extended spectrum β-lactamase (ESBL) or ampicillin C (AmpC) β-lactamase produ

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Rodrigues, Lilian de Oliveira. "Detecção de beta-lactamase de espectro estendido em membros da família Enterobateriaceae /." Araraquara : [s.n.], 2005. http://hdl.handle.net/11449/86619.

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Resumo: A produção de beta-lactamase de espectro estendido (ESBL) em membros da família Enterobacteriaceae pode conferir resistência a cefalosporinas de amploespectro, aztreonam e penicilinas. Devido a esse fenômeno, a detecção exata dos produtores de ESBL é essencial para a seleção apropriada da antibioticoterapia. Para detectar a produção de beta-lactamase de espectro estendido (ESBL) em bacilos Gram-negativos, foi usado um teste de triagem com os discos de aztreonam (ATM), ceftazidima (CAZ), cefotaxima (CTX) e ceftriaxona (CRO) sobre 300 cepas, das quais trinta e cinco eram suspeitas da pre

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Yeung, Man-kiu, and 楊敏翹. "Epidemiology of CTX-M type extended-spectrum beta-lactamase-producing escherichia coli among blood culture isolates in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47326232.

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Dissemination of CTX-M type extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) is a serious health issue in Hong Kong. However, research knowledge concerning its dissemination mechanism and plasmid characteristics over time in health care setting is still limited. This study was conducted to characterize ESBL-producing E. coli from blood culture isolates and the epidemiology of the plasmids harboring CTX-M-14 collected from a healthcare region in Hong Kong from two periods of time. A total of 167 ESBL-producing E. coli in blood culture specimens were retrieved

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Manenzhe, Rendani Innocent. "Epidemiology of extended spectrum beta-lactamase and carbapenemase-producing bacteria in stool from apparently healthy children, South Africa." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/15599.

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Background: The prevalence of extended-spectrum beta-lactamase (ESBL) - and carbapenemase-producing Enterobacteriaceae in healthy humans in the community is largely unknown. We aimed to determine the prevalence and genetic characteristics of ESBL- and carbapenemase-producing Enterobacteriaceae in stools from healthy infants and their mothers, and to determine the risk factors associated with their carriage. Methods: This study was nested within the Drakenstein Child Health Study, a birth cohort in a semi-rural region of Western Cape Province, South Africa. Maternal and infants faecal samples (

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Weldhagen, Gerhard Frederick. "Laboratory Detection and Gene Cassette Stability of the Novel Extended-Spectrum Beta-Lactamase, GES-2 from Pseudomonas aeruginosa." Thesis, University of Pretoria, 2004. http://hdl.handle.net/2263/29221.

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Extended-spectrum beta-lactamases (ESBLs) in Pseudomonas aeruginosa tend to be geographically scattered, such as GES-2, which partially compromises the efficacy of imipenem. The G170N mutation, ascribed to a CC to AA base pair substitution on positions 493-494 of the blaGES-2 coding region, distinguishes this ESBL from blaGES-1 and the blaIBC-type genes, making it an ideal target for developing a novel sequence-specific, peptide nucleic acid (PNA)-based, multiplex-PCR detection method. Utilizing two primer pairs in conjunction with a PNA probe, this novel method delivered accurate identificati

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Büchter, Britta [Verfasser]. "Vorkommen und Charakterisierung von Extended-Spectrum-Beta-Laktamase (ESBL)-produzierenden Escherichia coli bei Lebensmittel liefernden Tieren / vorgelegt von Britta Büchter." Berlin : mbv, Mensch-und-Buch-Verl, 2010. http://d-nb.info/1012988880/34.

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Card, Galen Edward. "The Diversity Found Among Carbapenem-Resistant Bacteria." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/6949.

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This work will look at two factors that add to the diversity of carbapenem resistant bacteria. First, it focuses on the diversity of carbapenemase resistance plasmids. 446 plasmids were characterized by size, gene content and replicon groups. We identified that on average, over 30% of the encoded proteins on each plasmid have an unknown function. Plasmid sizes ranged from 1.6kb to 500kb, with an average of around 100kb and median of 80kb. Additionally, six replicon groups account for 80% of all the carbapenemase resistance plasmids. We also highlight the lack of data available for carbapenemas

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Gqunta, Kwanele. "Prevalence and molecular epidemiology of extended-spectrum beta-lactamase-producing and carbapenem-resistant enterobacteriaceae, acinetobacter baumannii and pseudomonas aeruginosa in Port Elizabeth." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/d1020944.

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Multidrug resistant (MDR) extended-spectrum β-lactamase (ESBL)-producing and carbapenem-resistant Gram-negative bacteria have become an international health issue limiting treatment options. The objective of this study was to determine the prevalence of carbapenem-susceptible (CS) and carbapenem-resistant (CR) Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa and investigate clinical isolates for their resistant genes/ determinants. A total of 98 bacterial isolates (59 CS and 39 CR) were collected between February 2012 and February 2013 at NHLS, after being recovered from

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Saliu, Eva-Maria [Verfasser]. "The impact of feed additives on prevalence and conjugation of extended-spectrum beta-lactamase-producing Enterobacteriaceae in poultry / Eva-Maria Saliu." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/122202943X/34.

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Ogunbosi, Babatunde Oluwatosin. "Colonisation with extended spectrum beta-lactamase producing and carbapenem-resistant enterobacterales in children admitted to a paediatric referral hospital in South Africa." Master's thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32901.

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Introduction: There are few studies describing colonisation with extended spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) and carbapenem-resistant Enterobacterales (CRE) among children in subSaharan Africa. Colonisation often precedes infection and multi-drug-resistant Enterobacterales are important causes of invasive infection. Methods: In this prospective cross-sectional study, conducted between April and June 2017, 200 children in a tertiary academic hospital were screened by rectal swab for EBSL-PE and CRE. The resistance-conferring genes were identified using polymerase chain

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Gonçalves, Ana Lúcia Saraiva. "Avaliação da produção de β-lactamase em pseudomonas aeruginosa obtidas de dois Hospitais de Porto Alegre". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2005. http://hdl.handle.net/10183/24617.

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Objetivos: Avaliar o perfil de suscetibilidade, a prevalência da produção de AmpC, β-lactamase de espectro estendido (ESBL) e Metalo-β-lactamase (M-βla) em Pseudomonas aeruginosa obtidas de dois hospitais universitários distintos (ISCMPA e HCPA) em Porto Alegre. Em adição, tipagem molecular por PFGE foi realizada entre os isolados produtores de M-βla para avaliar a relação clonal. Métodos: Foi determinada a suscetibilidade de 238 isolados de P. aeruginosa para 8 agentes antimicrobianos, através do teste de disco-difusão, usando agar Müller-Hinton (MH) de acordo com “National Committee for Clin

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Timmerbeil, Björn S. [Verfasser]. "Entwicklung eines PyrosequencingTM-basierten Verfahrens zum genetischen Nachweis der in Europa prävalenten extended-spectrum beta-lactamases (ESBLs) sowie Identifizierung und biochemische Charakterisierung der neuen BlaTEM-Variante TEM-142 / Björn S Timmerbeil." Aachen : Shaker, 2007. http://d-nb.info/1164339486/34.

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Grimm, Verena Ulrike. "Development of a diagnostic microarray for the rapid detection of extended spectrum beta-lactamases for the use in clinical microbiology Entwicklung eines diagnostischen Mikroarrays zum Nachweis von Beta-Laktamasen mit erweitertem Wirkungsspektrum für den Einsatz in der klinischen Mikrobiologie /." [S.l. : s.n.], 2005. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-24812.

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Adeyemi, Oluwatosin Oluwakemi. "Comparative in-vitro activities of trimethoprimsulfamethoxazole and the new fluoroquinolones against confirmed extended spectrum beta-lactamase producing Stenotrophomonas maltophilia in Nkonkobe Municipality, Eastern Cape environment." Thesis, University of Fort Hare, 2012. http://hdl.handle.net/10353/d1007576.

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Stenotrophomonas maltophilia is increasingly emerging as an opportunistic pathogen of global concern. Due to its inherent resistance to several classes of antibiotics including carbapenems and its ability to acquire mobile resistance elements, treatment of infections caused by S. maltophilia is a constant challenge for clinicians. Trimethoprim-sulphamethoxazole (TMP-SMX) is the generally accepted antibiotic of choice for the treatment of infections caused by this organism, but resistance to the drug is increasingly being reported; hence, the need for alternative therapeutic options. In this st

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Vasques, Márcia Regina Guimarães. "Estudo sobre a ocorrência de enterobactérias produtoras de ESBL isoladas de pacientes internados em unidades de pós-operatório de cirurgia cardíaca de um hospital da rede pública do Rio de Janeiro." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4417.

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As infecções associadas aos cuidados de saúde constituem um problema grave nas unidades hospitalares bem como nos serviços de atendimento extra-hospitalares. Diferentemente de outros países, no Brasil, existe uma incidência alta dessas infecções causadas por microorganismos Gram-negativos produtores de β-lactamase de espectroestendido (ESBL). Estas enzimas hidrolisam compostos β-lactâmicos e são consideradas mundialmente como de importância clínica, pois a localização de seus genes emelementos móveis facilitam a transmissão cruzada. Este estudo foi realizado com amostras bacterianas

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Kreausukon, Khwanchai [Verfasser]. "Usage of antimicrobials on 60 dairy farms in Northern Germany and characterization of Methicillin-resistant staphylococcus aureus (MRSA) and extended spectrum beta-lactamases producing Escherichia coli (ESBLs-producing E. coli) isolated from bulk tank milk samples / Khwanchai Kreausukon." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1026174449/34.

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Huang, YaLi, and 黃雅勵. "The Association of Virulence between Capsule Regulator Gene, rmpA, and Extended-Spectrum Beta-Lactamase (ESBL)-Producing Klebsiella pneumoniae." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/11350454155237099713.

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FU, LI-LING, and 傅麗玲. "Clinically isolated Escherichia coli with the extended-spectrum beta-lactamases (ESBL) property have plasmids related to its ESBL." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/10388332210853874965.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>103<br>After 1983, Extended-spectrum β-lactamases (ESBL) were discovered. They are distributed between bacteria via a plasmid with a mutant form of this enzyme. Most of the plasmids with these genes have a size greater than 100 kb. By changing one or more amino acid of these enzymes through mutations, they will be able to hydrolyze more cephalosporin antibiotics, resulting a major worry on infection control. Therefore, we want to explore whether the clinically isolated intestinal bacteria with ESBL characteristics have ESBL-containing plasmids, allowing them to be

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