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Dissertations / Theses on the topic 'Escherichia coli. Pathology, Molecular'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Jalajakumari, Meachery Bhaskaran. "Molecular organization and functional analysis of the CFA/II CS3 region of Enterotoxigenic Escherichia coli /." Title page, abstract and contents only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phj26.pdf.

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2

Lau, Siu Ha. "Molecular epidemiology of pathogenic escherichia coli." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517731.

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3

Rang, Camilla. "Molecular and physiological characteristics of Escherichia coli growth in vitro and in the gastrointestinal tract of mice." Göteborg : [Dept. of General and Marine Microbiology, Göteborg University], 1997. http://catalog.hathitrust.org/api/volumes/oclc/38988157.html.

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4

Batley, Charlotte. "Molecular analysis of iron-storage in Escherichia coli." Thesis, University of Reading, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501326.

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Cellular iron is stored within protein molecules generically called 'ferritins'. Such iron-storage molecules are composed of either 12 or 24 structurally identical subunits that form a spherical shell around a central storage cavity with the capacity to accept 500-4,500 h-on atoms in the form core E. coli contains four ferriritin-like proteins, FtnA, Bfr, Dps and FtnB, the latter of which is yet to be characterised. A bacterial-2-hybrid approach was used to investigate interactions of E. coli FtnA, Bfr, FtnB and Bfd proteins with each other, and of Bfr with other E. coli proteins expressed fro

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5

Drake, C. Rachel. "Molecular studies of Escherichia coli capsule gene clusters." Thesis, University of Leicester, 1991. http://hdl.handle.net/2381/35353.

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Molecular studies of Escherichia coli capsule gene clusters C. Rachel Drake Escherichia coli can produce a large number (over 70) of structurally distinct capsular polysaccharide (K antigens) which have previously been divided into two groups. Group II K antigens are encoded by kps near serA. The kps genes are homologous between group II capsule gene clusters which encode chemically distinct K antigens. Genes encoding the K4 antigen (group II), an unusual substituted polymer (a fructo-sylated chondroitin), were cloned and expressed in E. coli K-12 and shown to contain the group II kps determin

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6

Hook-Barnard, India G. "Molecular analysis of regulatory elements within the escherichia coli fepB leader mRNA." free to MU Campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091932.

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7

Ho, Joanne Ming-Li. "Towards Sense Codon Reassignment in Escherichia Coli." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718706.

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Expansion of the genetic code through engineering of the translation machinery has vastly increased the chemical repertoire of the proteome. Incorporation of non-canonical amino acids (ncAAs) entails use of engineered aminoacyl-tRNA synthetase (AARS)•transfer RNA (tRNA) pairs that do not interact with the canonical aminoacylation machinery. Although engineered AARSs are selected for their ability to utilize ncAAs and discriminate against the twenty canonical amino acids, many utilize other ncAAs – a phenomenon known as polyspecificity. Specific incorporation of multiple ncAAs in a single polyp

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8

Meric, Guillaume. "Molecular and ecological characterisation of Escherichia coli from plants." Thesis, University of East Anglia, 2011. https://ueaeprints.uea.ac.uk/47954/.

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Escherichia coli is routinely isolated from vegetables and there is increasing evidence that plants are a secondary reservoir for commensal and pathogenic strains, but the ecological factors involved in the persistence of E. coli on plants are not clear. In this thesis, a comparative study was undertaken combining phenotypic and phylogenetic analyses of E. coli isolates from salads grown in the UK and the faeces of mammalian hosts. In vitro phenotypic profiling revealed significant differences according to the source of isolation: strains from plants were in the majority from phylogroup B1, di

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9

Hopkins, Katie Louise. "Molecular methods for strain characterisation of Escherichia coli O157." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368793.

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10

Silveira, Flávio 1986. "Caracterização molecular de isolados brasileiros de Escherichia coli aviária." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317368.

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Orientador: Wanderley Dias da Silveira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-23T07:50:57Z (GMT). No. of bitstreams: 1 Silveira_Flavio_M.pdf: 7271586 bytes, checksum: 61c4ca3b97e4b7443d820cd714394fa8 (MD5) Previous issue date: 2013<br>Resumo: O resumo poderá ser visualizado no texto completo da tese digital<br>Abstract: The abstract is available with the full electronic document<br>Mestrado<br>Microbiologia<br>Mestre em Genética e Biologia Molecular

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11

Nicholson, Brian Christopher. "Novel Suicide Elements for Gene Disruption in Escherichia coli." W&M ScholarWorks, 1994. https://scholarworks.wm.edu/etd/1539625872.

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12

Bendezu, Felipe Oseas. "CELL SHAPE DETERMINATION IN ESCHERICHIA COLI." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1215459479.

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13

Sen, Hrishiraj. "Escherichia coli responses to acid-stress : signal transduction and gene regulation." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8140/.

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Microbial lab-based evolution is a technique to study evolutionary theory. It is a method which can provide insights into the ability of a microbe to adapt to a biological process such as low pH. To investigate pathways that could lead to an acid resistant phenotype in E. coli, we evolved six independent lines or populations of E. coli K-12 MG1655 by iterative growth and dilution experiments for approximately 740 generations at pH 4.5. Clones isolated from evolved populations were significantly fitter than the ancestor at pH 4.5. Five of the six evolved strains had acquired an identical mutati

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14

Sjöström, Annika E. "Pathogenecity-associated genes modulate Escherichia coli adhesion and motility." Doctoral thesis, Umeå universitet, Molekylärbiologi (Medicinska fakulteten), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22302.

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Escherichia coli strains typical of UPEC (uropathogenic E. coli) and NBM (newborn meningitis) isolates carry chromosomally located PAIs (pathogenicity islands) that are absent in non-pathogenic E. coli strains. The PAIs include genes for virulence factors such as toxins and genes coding for specific adhesins and pili/fimbriae formation. Commonly, the gene clusters for such fimbriae in E. coli consist of a set of genes for biogenesis of the actual fimbriae organelles: a chaperone, an usher, the fimbrial subunits, and an adhesin, as well as some regulatory genes. Genetic studies of the fimbrial

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15

Clark, Ewan M. "Characterisation of Escherichia coli of the bovine intestinal tract." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/706/.

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Enterohaemorrhagic E. coli (EHEC) are important gastrointestinal pathogens of humans. E. coli serotype O157:H7 is the EHEC most commonly associated with human illness. E. coli O157:H7 is carried asymptomatically by cattle which form an important reservoir for the bacterium. E. coli O157:H7 has been found to colonise at the terminal rectum of cattle in preference to other sites in the bovine gastrointestinal tract. The first objective of this work was to characterise the roles of bacterial secreted components responsible for key functions in the modulation of host defences against EHEC. Data pr

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16

Eisenhauer, H. Anne. "Siderophore transport through Escherichia coli outer membrane receptor FhuA." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84026.

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Hydroxamate siderophore receptor FhuA is a TonB-dependent outer membrane protein of Escherichia coli composed of a C-terminal 22-stranded beta-barrel occluded by an N-terminal globular cork domain. During transport of siderophores into the periplasm, FhuA is proposed to undergo conformational changes that may form a pathway across the barrel. To probe structural changes, site-directed cysteine mutants of selected amino acids in the cork domain (L109C and Q112C) and in the barrel domain (S356C and M383C) were created within the putative siderophore transport pathway. Molecular modeling p

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17

Fortin, Doris Laurence. "Characterization of D108 Ner and its Escherichia coli homolog Nlp." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20822.

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Mu and D108 are temperate bacteriophages which can follow two possible modes of growth after infection of Escherichia coli. The bacteriophages can follow the lytic cycle, in which the bacteriophage genome is replicated and progeny phages are produced, or the lysogenic cycle, in which the bacteriophage remains dormant in the E. coli genome. In this case, the bacteriophage's DNA is replicated along with the host chromosome. Central to the lytic/lysogenic switch, is the Ner protein. Ner is a small, basic, DNA-binding protein. To better understand the mechanism by which bacteriophage D108 regulate

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18

Cho, SungAe. "Lac Operon Expression in Steady State Cells of Escherichia coli." W&M ScholarWorks, 1985. https://scholarworks.wm.edu/etd/1539625294.

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19

Harris, Reuben Stewart. "On a molecular mechanism of adaptive mutation in Escherichia coli." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq21574.pdf.

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20

Cheung, Yuk-yam, and 張煜鑫. "Molecular epidemiology of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196450.

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Increasing carbapenem resistance among clinical isolates of E. coli and K. pneumoniae has become a serious public health problem over the last decade. Molecular epidemiology studies have shown that there is a global dissemination of epidemic clones of carbapenem-resistant E. coli and K. pneumoniae. Besides, successful epidemic plasmids were reported to disseminate carbapenemase genes in Enterobacteriaceae. The wide spread of carbapenem-resistant E. coli and K. pneumoniae limits treatment options of the infection, poses severe challenges to clinical professionals and threatens our health. Re

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21

Farrant, Jayne Lisa. "Molecular characterisation of the virulence determinants of enteropathogenic Escherichia coli." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385084.

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22

Smith, Annabel N. "Molecular analysis of capsular polysaccharide biosynthesis in Escherichia coli K5." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/35418.

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Escherichia coli can produce over 70 structurally distinct acidic capsular polysaccharides (K antigens) and these have been divided into two groups. The genetic determinants required for the expression of group II K antigens map at kps and have previously been shown to have a conserved genetic organization consisting of three functional regions. The nucleotide sequence of region 3 of the K5 kps locus was determined and this revealed the presence of two genes, kpsM and kpsT. KpsM and KpsT have characteristics in common with members of the ABC family of membrane transporters and since region 3 h

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23

Mkabayi, Lithalethu. "Molecular cloning and expression of equine CYP1A2 in Escherichia coli." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/4830.

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Information regarding drug metabolism in veterinary species, especially horses, remains fragmented and incomplete. This information is essential for detection of metabolites of potential performance-enhancing substances in horseracing and for veterinary drug development. Equine liver microsomes have been used to study metabolism of a limited number of drugs, but these provide little information about individual drug metabolizing enzymes. Recombinant CYP enzyme systems are commonly used to determine contribution of individual CYP to metabolism of specific drugs. A limited number of recombinant

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24

Dashti, Ali. "Molecular characterisation of ESBLs from Klebsiella pneumoniae and Escherichia coli." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23320.

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In this study, one hundred-and-one unique patient isolates of <i>K. pneumoniae </i>(69) and <i>E. coli</i> (32), flagged as ESBL positive by the Vitek system (GNS 526 card) were collected. These strains were isolated from a variety of clinical specimens submitted to the clinical bacteriology laboratories of the Royal Infirmary of Edinburgh (RIE). Of the 101 strains tested, 15 <i>E. coli</i> were subsequently found to be ESBL-negative by E-test ESBL strips. On re-testing with Vitek using the (GNS 532 card which had superseded the GNS 526 card), 14 of these were found to be ESBL-negative despite

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25

Esumeh, Frederick I. "Molecular studies of the Escherichia coli K5 capsule gene cluster." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/35364.

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Group II K antigens such as the K5 are associated with Escherichia coli causing serious extraintestinal infections. Genes for the production of group II capsules (kps) are organised into three functional regions 1, 2 and 3. The central region 2 encodes proteins involved in the biosynthesis of type specific polysaccharide. Proteins encoded by the flanking regions 1 and 3 are involved in the export of polysaccharide across the bacterial membranes unto the cell surface. Translocation of polysaccharide across the inner membrane is mediated by two region 3 encoded proteins, KpsM and KpsT which belo

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26

Cassago, Alexandre. "Estudos moleculares da Selenocisteína Sintase (SELA) de Escherichia coli." Universidade Federal de São Carlos, 2005. https://repositorio.ufscar.br/handle/ufscar/5560.

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Made available in DSpace on 2016-06-02T20:21:38Z (GMT). No. of bitstreams: 1 DissAC.pdf: 5109781 bytes, checksum: 28cbdff07dea548d38125e3c33251370 (MD5) Previous issue date: 2005-05-05<br>Financiadora de Estudos e Projetos<br>The study of translation processes attracts the interest of a wide range of research groups due to its main role in general cellular metabolism. In particular, the investigation of new amino acid residues, such as selenocysteine and pyrrolysin, which result in an expansion of the genetic code from the traditional 20 residues to a total of 22 residues up to the current t

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27

Aguena, Meire. "Análise transcricional do operon pst de Escherichia coli." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-30012008-094907/.

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O operon pst de Escherichia coli é formado pelos genes pstS, pstC, pstA, pstB e phoU. Os quatro primeiros genes codificam proteínas que compõem um sistema de transporte do tipo ABC denominado Pst. O sistema Pst, junto com a proteína PhoU participa da repressão dos genes do regulon PHO. A transcrição dos genes do operon pst é induzida pela carência de fosfato inorgânico (Pi). Neste trabalho, o padrão de transcrição do operon pst foi analisado. A existência de um transcrito primário instável foi comprovada através de uma nova técnica de RT-PCR. O papel da RNase E na degradação do mRNA de pst foi

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28

Li, Yali. "Biochemical and structural studies of Escherichia coli chaperone groel-substrate interaction." [Bloomington, Ind.] : Indiana University, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3386696.

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Thesis (Ph.D.)--Indiana University, Dept. of Biochemistry, 2009.<br>Title from PDF t.p. (viewed on Jul 22, 2010). Source: Dissertation Abstracts International, Volume: 70-12, Section: B, page: 7367. Adviser: Lingling Chen.

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29

Dachs, Gabriele Ursula. "The effect of metronidazole on Bacteroides fragilis and Escherichia coli." Doctoral thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/18281.

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The antibiotic metronidazole is used extensively in the clinical treatment of anaerobic infections, including those caused by the anaerobic pathogen Bacteroides fragilis. Metronidazole is an inert substance that requires reductive activation to become cytotoxic. In its activated form metronidazole induces DNA damage. Relatively little is known about the cytotoxic effects of this drug in vivo. The aim of the work reported in this thesis was to analyze the mode of action of metronidazole in living systems. Furthermore, the potential for bacterial cells to develop resistance mechanisms to metroni

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30

Anglès, Frédéric. "Impact of the molecular chaperone HSP70/DnaK on the Escherichia coli central metabolism." Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30126.

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Le réseau de protéines chaperons est hautement conservé dans l'ensemble du vivant. Il régule l'homéostasie des protéines au sein de la cellule en condition de croissance normale ainsi qu'en réponse à des stress environnementaux. Les chaperons membres de la famille HSP70 (Heat Shock Protein 70 kDa), famille particulièrement conservée, agissent tout au long de la biogénèse des protéines et orchestrent une pléthore de processus cellulaires liés au repliement et/ou au remodelage de protéines. Le cycle ATP-dépendant du chaperon HSP70 repose sur une étroite collaboration avec ses partenaires co-chap

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31

Tavares, Rafaela. "Surface expression of Chromobacterium violaceum transaminase in Escherichia coli." Thesis, KTH, Skolan för bioteknologi (BIO), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-49131.

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32

Quigley, Paulene. "Structural studies of the chaperone Hsp31 from Escherichia coli /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8696.

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33

Pfrimer, Pollyanna. "Expressão de uricase de Bacillus subtilis em Escherichia coli." reponame:Repositório Institucional da UnB, 2007. http://repositorio.unb.br/handle/10482/3312.

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Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, 2007.<br>Submitted by Thaíza da Silva Santos (thaiza28@hotmail.com) on 2009-12-15T19:46:20Z No. of bitstreams: 1 2007_PollyannaPfrimer.pdf: 1059709 bytes, checksum: 8164ee6bf9cb611160660a0168601a11 (MD5)<br>Approved for entry into archive by Lucila Saraiva(lucilasaraiva1@gmail.com) on 2010-01-18T22:07:47Z (GMT) No. of bitstreams: 1 2007_PollyannaPfrimer.pdf: 1059709 bytes, checksum: 8164ee6bf9cb611160660a0168601a11 (MD5)<br>Made available in DSpace on 2010-01-18T22:07:47Z (G

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34

Yam, Wing-cheong. "Molecular epidemiology of enterotoxigenic escherichia coli and vibrio cholerae in Hong Kong /." [Hong Kong : University of Hong Kong], 1990. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12966381.

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35

Ree, Johannes Mathijs de. "Molecular and serological characterization of p fimbriae from uropathogenic escherichia coli." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1986. http://arno.unimaas.nl/show.cgi?fid=5322.

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36

Paton, Adrienne Webster. "Molecular characterization of variant shiga-like toxin genes of Escherichia coli /." Title page, contents and abstract only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09php3118.pdf.

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37

Schuster, Cordelia Friederike. "Structural and molecular characterisation of the oligopeptide permease of Escherichia coli." Thesis, Bangor University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262450.

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38

Aleanizy, Fadilah. "Investigating the molecular mechanisms of colicin import into Escherichia coli cells." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12408/.

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Colicins are a family of bacterial toxins, which kill Escherichia coli cells and other closely related species. Their mode of action requires binding to an outer membrane receptor, translocation across the cell envelope leading to cytotoxicity at specific targets. The mechanism of colicin cytotoxicity includes a non-specific endonuclease activity or depolarizing of the cytoplasmic membrane by pore-forming activity. The cytotoxic activity can be inhibited by the high affinity binding of an immunity protein. For Group A colicins, translocation requires interaction between the N-terminal domain o

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39

Robertson, Kirstin Patricia. "Molecular analysis of the ferrous iron transporter FeoABC in Escherichia coli." Thesis, University of Reading, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577985.

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Most bacteria have an inherent need for iron, as it is a component of various enzymes involved in vital metabolic processes. Therefore, bacteria have evolved several mechanisms to acquire iron from the environment. Bacterial iron transporters allow the active uptake of both ferrous and ferric iron. Escherichia coli is believed to possess two high-affinity ferrous iron transport systems: EfeUOB (which is induced under acidic conditions) and Feo (which is anaerobically induced). Feo consists of three proteins, FeoA, FeoB and FeoC, encoded by a three-gene operon,jeoABC. FeoB is an integral membra

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40

Leung, Hang-mei Polly, and 梁杏媚. "Epidemiology and molecular genetics of verocytotoxigenic escherichia coli in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31245663.

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41

Chan, Jane, and 陳曉婷. "Molecular epidemiology of fosfomycin-resistant Escherichia coli from humans and animals." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197077.

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The diminishing choice of effective antibiotics against resistant pathogens has forced clinicians to revive the use of old antibiotics. Hence, fosfomycin has been frequently suggested for alternative therapies given its track record of low resistance rates despite extensive use. However, there have been recent reports of plasmid-mediated fosfomycin resistance among animals and healthy humans in Asia. Accordingly, comparison of shared fosfomycin resistance mechanisms between animals and humans will shed light on the spread of resistance and guide future use of antimicrobials. This study aime

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42

Mulcahy, Marian P. B. "A genetic and molecular study of phenylalanine transport in Escherichia coli." Thesis, University of Dundee, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655207.

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43

Ralph, Edward T. "Molecular characterisation of FNR, the anaerobic transcription regulator of Escherichia coli." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323194.

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44

Thomas, Andrea. "The molecular detection and differentiation of Vero cytotoxin-producing Escherichia coli." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239836.

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45

Morris, Terry Lynn. "Molecular characterization of the fepA-fes bidirectional promoter in escherichia coli." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3025640.

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46

Vilchez, Rugama Bayardo Samuel. "Molecular and phenotypic characterization of diarrhoeagenic Escherichia coli from Nicaraguan children." Stockholm : Division of Laboratory Medecine, Karolinska Institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-718-4/.

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47

Thomas, Jeffrey G. "Molecular chaperones and the folding of recombinant proteins in Escherichia coli /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/9881.

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48

Belle, Jerilyn Jalana. "Molecular processing of replication intermediates in Escherichia coli after DNA damage." Diss., Mississippi State : Mississippi State University, 2007. http://library.msstate.edu/etd/show.asp?etd=etd-03192008-103657.

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49

Chittum, Harold S. "A Molecular Basis for Erythromycin Sensitivity and Resistance in Escherichia Coli." Digital Commons @ East Tennessee State University, 1993. https://dc.etsu.edu/etd/2655.

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The effect of erythromycin on the 50S ribosomal subunit during cell growth has been extensively investigated. Sucrose density gradient analysis of ribosomes formed in the presence and absence of the drug revealed a 50S specific assembly defect is partially responsible for erythromycin's inhibitory effects on wild type cells. Examination of two erythromycin-resistant mutants of E. coli (N281 and N282) revealed that mutant N281 (L22 mutant) but not N282 (L4 mutant) was assembly defective in the presence of the drug, although only at much higher drug concentrations (300 ug/ml vs. 75 ug/ml for wil

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50

Wiselka, Martin Joseph. "A molecular analysis of non-fimbrial adhesins in uropathogenic Escherichia coli." Thesis, University of Leicester, 1991. http://hdl.handle.net/2381/33623.

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Bacterial adherence is one of the most important virulence factors in the pathogenesis of urinary tract infections. The majority of clinical isolates of Escherichia coli adhere to uroepithelial cells via specific organelles known as fimbriae or pili which project from the surface. A proportion of urinary isolates possess adhesins which diffusely surround the bacteria forming an adhesive protein capsule. These are described as non-fimbrial adhesins. The molecular biology and clinical significance of this group of adhesins is relatively poorly understood. The work presented in this thesis descri

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