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Journal articles on the topic 'Escort Carriers'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2025

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1

Wheeler, Gerald E., and William T. Y'Blood. "The Little Giants: U.S. Escort Carriers against Japan." American Historical Review 94, no. 1 (1989): 237. http://dx.doi.org/10.2307/1862263.

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2

Uhlig, Frank, and William T. Y'Blood. "The Little Giants: U. S. Escort Carriers Against Japan." Journal of Military History 53, no. 2 (1989): 199. http://dx.doi.org/10.2307/1985755.

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3

Patterson II, Charles Ross. "Venner F. Milewski, Jr., Fighting Ships of the U.S. Navy 1883-2019, Vol. One, Part Two – Aircraft Carriers, Escort Carriers by Charles Ross Patterson II." Northern Mariner / Le marin du nord 33, no. 1 (2023): 131–32. http://dx.doi.org/10.25071/2561-5467.1107.

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4

Brigham, Lawson W. "The Northern Sea Route, 1998." Polar Record 36, no. 196 (2000): 19–24. http://dx.doi.org/10.1017/s0032247400015941.

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AbstractBy any measure, 1998 was a year of conflicting domestic and international interests regarding Russia's Northern Sea Route (NSR). The European Union sponsored an international demonstration project using a Finnish tanker during an April and May voyage to the Kara Sea. Russian icebreakers escorted the tanker, which carried a cargo of gas condensate from the Ob estuary to Europe. The International NSR Programme (INSROP) continued during a fifth year of interdisciplinary research concentrating on the integration of previous results and NSR voyage simulations. Lukoil and Gazprom forged ahea

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5

Ding, Taoli, Jing Yang, Victor Pan, et al. "DNA nanotechnology assisted nanopore-based analysis." Nucleic Acids Research 48, no. 6 (2020): 2791–806. http://dx.doi.org/10.1093/nar/gkaa095.

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Abstract Nanopore technology is a promising label-free detection method. However, challenges exist for its further application in sequencing, clinical diagnostics and ultra-sensitive single molecule detection. The development of DNA nanotechnology nonetheless provides possible solutions to current obstacles hindering nanopore sensing technologies. In this review, we summarize recent relevant research contributing to efforts for developing nanopore methods associated with DNA nanotechnology. For example, DNA carriers can capture specific targets at pre-designed sites and escort them from nanopo

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6

Park, Myunghwan, Seunghoon Yoo, Jihyon Oh, and Hyeonju Seol. "The Development of Air Escort Tactics for High-Value Airborne Assets Using Manned-Unmanned Teaming and the Study on Effective Force Disposition Using M&S." Journal of the Korea Institute of Military Science and Technology 25, no. 4 (2022): 401–11. http://dx.doi.org/10.9766/kimst.2022.25.4.401.

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As the role of high-value air assets(e.g., AWACS, JSTARS, Rivet Joint, E-2) becomes more critical in modern warfare, the air escort for these assets blocking attacks from any potential enemy fighter also becomes vital. Without the escort, the operations of the assets become restricted. However, such an escort is not always possible due to the limited flight time of the escort fighters. In this paper, we introduce an escort tactics for high-value air assets performed by the manned-unmanned teaming composed of a transport aircraft and UAVs(unmanned aerial vehicles). In this tactics, the transpor

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7

Ryzhikov, M. B., Yu A. Novikova, I. A. Kirshina, and V. G. Svanidze. "Energy ratios, types of probing signals and intra-period signal processing in airborne radars designed to build maps of the Arctic ground surface." T-Comm 18, no. 6 (2024): 29–37. https://doi.org/10.36724/2072-8735-2024-18-6-29-37.

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The Arctic region attracts more and more attention from year to year. Technical, political and target conditions for the active use of the Arctic have been formed. Modern geological exploration tools have identified the locations and characteristics of rich mineral deposits. Large scale measures have been carried out to develop Arctic shipping, which allows for large intercity and international transport flows. There is an active formation of the Arctic infrastructure: scientific research bases, large industrial enterprises, objects of extraction of fossil materials, as well as civilian settle

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8

Waddell, Steve R. "Twenty-Three Minutes to Eternity: The Final Voyage of the Escort Carrier U.S.S.Liscome Bay." History: Reviews of New Books 33, no. 1 (2004): 12. http://dx.doi.org/10.1080/03612759.2004.10526378.

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9

Suyadi, Yanu Madawanto, and Salim. "Pengaruh Pelatihan Dan Disiplin Kerja Terhadap Kinerja Prajurit Satuan Kapal Eskorta Koarmada II." Coopetition : Jurnal Ilmiah Manajemen 12, no. 2 (2021): 279–88. http://dx.doi.org/10.32670/coopetition.v12i2.480.

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Escort ship is a warship designed for the duties of guarding and protecting a main body or not of high value when a formation is carrying out sea crossing tasks. The Escort ship is also the main element of the convoy's protection. The crew member factor is a determinant of the ability level of the Escort Ship Unit and the readiness of other equipment. As the main factor, human resource must have high quality, readiness and discipline. Each individual and group must be skilled and work, and have good discipline. The existence of discipline and individual performance of the Escort Ship Unit and

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10

Jin, Yuan, Chun Hua Wang, and Ke Li. "Study on Mechanical Automation with Design of Digital Function Generator." Advanced Materials Research 703 (June 2013): 260–63. http://dx.doi.org/10.4028/www.scientific.net/amr.703.260.

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Digital function generator is widely used in mechanical automation,such as mechanical automation control and all kinds of electronic circuits. This paper firstly introduces the principle of digital waveform synthesizer and explains the specific realization method of the digital waveform synthesizer circuit. Next, it is carries on the detailed narration of the principle of DDS, the description of DDS specific design from FPGA, and provides parameter selection of the subsequent simulation processing circuit with 125 KHZ sine signal as an example. Finally, contrast the sine signal generated by th

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11

Bigornia, Veronica E. "U.S. Navy Aircraft Carrier Prevents Outbreak at Sea in Midst of COVID-19." Military Medicine 186, no. 7-8 (2021): 178–80. http://dx.doi.org/10.1093/milmed/usab107.

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ABSTRACT Background The USS Harry S Truman Strike Group deployed from Norfolk, VA in November 2019 with a crew of 5,461 personnel and successfully returned to home port in June 2020 with zero cases of COVID-19. Methods Senior Medical Officer’s observations and description of the evolution of the pandemic, impact to the crew of the USS Harry S Truman, a nuclear-powered aircraft carrier, and the public health principles and outbreak prevention protocols used to prevent an outbreak at sea. Results The USS Harry S Truman Carrier Strike Group was composed of 4,810 personnel from Carrier Strike Grou

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Aoh, Quyen L., Anna M. Castle, Charles H. Hubbard, Osamu Katsumata, and J. David Castle. "SCAMP3 Negatively Regulates Epidermal Growth Factor Receptor Degradation and Promotes Receptor Recycling." Molecular Biology of the Cell 20, no. 6 (2009): 1816–32. http://dx.doi.org/10.1091/mbc.e08-09-0894.

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The epidermal growth factor receptor (EGFR) is targeted for lysosomal degradation by ubiquitin-mediated interactions with the ESCRTs (endosomal-sorting complexes required for transport) in multivesicular bodies (MVBs). We show that secretory carrier membrane protein, SCAMP3, localizes in part to early endosomes and negatively regulates EGFR degradation through processes that involve its ubiquitylation and interactions with ESCRTs. SCAMP3 is multimonoubiquitylated and is able to associate with Nedd4 HECT ubiquitin ligases and the ESCRT-I subunit Tsg101 via its PY and PSAP motifs, respectively.

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Stefańska, Katarzyna, Małgorzata Józkowiak, Ana Angelova Volponi, et al. "The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research." Cells 12, no. 3 (2023): 356. http://dx.doi.org/10.3390/cells12030356.

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Exosomes are biological nanoscale spherical lipid bilayer vesicles, 40–160 nm in diameter, produced by most mammalian cells in both physiological and pathological conditions. Exosomes are formed via the endosomal sorting complex required for transport (ESCRT). The primary function of exosomes is mediating cell-to-cell communication. In terms of cancer, exosomes play important roles as mediators of intercellular communication, leading to tumor progression. Moreover, they can serve as biomarkers for cancer detection and progression. Therefore, their utilization in cancer therapies has been sugge

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Gao, Xin Rui, De Qing Zhao, and Ping Ping Yao. "The 3D Computer Game Design Using Java 3D." Advanced Engineering Forum 6-7 (September 2012): 1041–44. http://dx.doi.org/10.4028/www.scientific.net/aef.6-7.1041.

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In this thesis, the two 3D computer games were designed by Java 3D. In the first game, by using 3DMax, one aircraft carrier, one helicopter, submarines, warships, and destroyer escorts etc were designed. By using Loader3DS of MicrocrowLoader in Loader3DS1_2.jar or ModelLoader of Java 3D, these 3D models are loaded into the Java 3D. The second 3D game displays the 3D fighting and collision of tanks. This function is very important for the 3D game design. By using textures, the different appearances of 3D models were designed. By using Java 3D classes such as Alpha and PositionPathInterpolator a

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Francisco, Márcio Tadeu Ribeiro, Thelma Spindola, Elizabeth Rose Costa Martins, Cristiane Maria Amorim Costa, Vinícius Rodrigues Fernandes Da Fonte, and Carina D'Onofrio Prince Pinheiro. "LIVING WITH THE HIV/AIDS CARRIER: OPINION OF CARNIVAL PARTICIPANTES." Revista de Pesquisa Cuidado é Fundamental Online 5, no. 4 (2013): 510–18. http://dx.doi.org/10.9789/2175-5361.2013.v5i4.510-518.

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Objetivo: Identificar a opinião das pessoas em relação a convivência com os portadores do HIV. Métodos: Tratou-se de uma pesquisa descritiva em abordagem quantitativa, realizada no Rio de Janeiro, em 2011. A amostra foi composta aleatoriamente por 630 integrantes dos desfiles das escolas de samba, pela aplicação de uma entrevista com roteiro estruturado. Os dados foram tabulados, organizados e analisados com auxílio da estatística descritiva. Sendo aprovado pelo CEP da Universidade Veiga de Almeida número 270/11. Resultados: A maioria dos entrevistados não teriam relações sexuais protegidas co

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16

Spitzer, Christoph, Francisca C. Reyes, Rafael Buono, Marek K. Sliwinski, Thomas J. Haas, and Marisa S. Otegui. "The ESCRT-Related CHMP1A and B Proteins Mediate Multivesicular Body Sorting of Auxin Carriers in Arabidopsis and Are Required for Plant Development." Plant Cell 21, no. 3 (2009): 749–66. http://dx.doi.org/10.1105/tpc.108.064865.

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17

Winkler, David F. "Langley’s Great Escape." Open Military Studies 2, no. 1 (2022): 55–65. http://dx.doi.org/10.1515/openms-2022-0122.

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Abstract The year 2022 will mark the centennial of the commissioning of the US Navy’s first aircraft carrier USS Langley. In late 1936, the ship was converted to become a seaplane tender and in 1939 is deployed to Manila. Following news reaching Admiral Hart and the Asiatic Fleet of the Japanese attack on Pearl Harbor, the arrival of Japanese bombers over Manila is imminent and the Langley is determined to be vulnerable to air attack. Departing Manila on December 9, Langley’s skipper Capt. Felix Stump served as the officer in tactical command of a convoy that also included the oilers Trinity a

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18

Perner, J., T. Hatalova, M. Cabello-Donayre, et al. "Haem-responsive gene transporter enables mobilization of host haem in ticks." Open Biology 11, no. 9 (2021): 210048. http://dx.doi.org/10.1098/rsob.210048.

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Ticks, notorious blood-feeders and disease-vectors, have lost a part of their genetic complement encoding haem biosynthetic enzymes and are, therefore, dependent on the acquisition and distribution of host haem. Solute carrier protein SLC48A1, aka haem-responsive gene 1 protein (HRG1), has been implicated in haem transport, regulating the availability of intracellular haem. HRG1 transporter has been identified in both free-living and parasitic organisms ranging from unicellular kinetoplastids, nematodes, up to vertebrates. However, an HRG1 homologue in the arthropod lineage has not yet been id

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19

Franck, Gerardo J., Hugo Prendes, José Huespe, and Silvina Mangini. "Análisis Numérico por CFD del Movimiento del Barco, su Propulsión y el Efecto en la Resuspensión de Sedimentos." Resúmenes de Mecánica Computacional 1, no. 21 (2025): 219. https://doi.org/10.70567/rmc.v1i21.227.

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Los buques graneleros transitan la hidrovía generando efectos hidrodinámicos en su entorno, los cuales, sumados a la los efectos turbulentos provocados por sus sistemas de propulsión pueden tener influencia sobre el lecho fluvial y modificarlo, especialmente en canales de aguas poco profundas. Entre dichos efectos se encuentran: redistribución del flujo y aceleración del mismo debajo de la quilla, con el consecuente aumento de las tensiones de corte ejercidas sobre las partículas que componen el lecho, pudiendo ocasionar erosiones, en el caso que superen a la tensión crítica del sedimento. Est

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Gultom, Elfrida R. "The Importance of Sea Boat as a Supporting Transportation Facility for People and Goods." SHS Web of Conferences 54 (2018): 06015. http://dx.doi.org/10.1051/shsconf/20185406015.

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KM. Sinar Bangun which sank in Lake Toba on June 18, 2018 caused 4 passengers died and 183 others missing. Four days later, the accident occurred again on the same lake, involved KM. Ramos Risna Marisi. The results of the investigation stated that this accident happens since the ship did not meet the seaworthy criteria and not feasible for sailing. Many cases about ship accidents are caused by other factors. Then, how are the rules regarding seaworthiness and ship loading according to the Regulation on Sea Transportation? Moreover, what are the efforts of the Government, Ship and Transport Own

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21

Pimont, Nathália Miasato, Mariana da Silva Marques, Rafael Alves Santomauro, Regina Mitsuka-Breganó, ItalmarTeodorico Navarro, and Fernanda Pinto-Ferreira. "Perfil de Cães Parasitados por Entamoeba spp. em Hospital Veterinário Escola." Ensaios e Ciência C Biológicas Agrárias e da Saúde 27, no. 4 (2023): 473–76. http://dx.doi.org/10.17921/1415-6938.2023v27n4p473-476.

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Entamoeba spp. são protozoários transmitidos pela ingestão de água e alimentos contaminados por cistos, causando, principalmente, alterações gastrointestinais em humanos e animais. Apenas as espécies Entamoeba coli e Entamoeba histolytica possuem relevância na medicina veterinária. Apesar dos cães portadores não serem capazes de infectar outros animais ou seres humanos, sua importância não deve ser negligenciada, pois sua presença indica precariedade nas condições higiênico-sanitárias. O objetivo deste estudo foi relatar o perfil de cães parasitados por Entamoeba spp. residentes no município d

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22

Krause, Gerd, and Katrin Manuela Hinz. "Molecular Mechanisms of Thyroid Hormone Transport by l-Type Amino Acid Transporter." Experimental and Clinical Endocrinology & Diabetes 128, no. 06/07 (2019): 379–82. http://dx.doi.org/10.1055/a-1032-8369.

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AbstractThyroid hormones (TH) pass through the plasma membrane into the target cells via transporter proteins. Thyroid hormone transporters that have been identified until now belong to two different solute carrier (SLC) subfamilies i) the major facilitator superfamily (MFS) and ii) the amino acid polyamine-organocation (APC) superfamily. Both are comprised by 12 transmembrane helices, however with different structural topology. The TH transporter MCT8, MCT10 and OATP1C1 are members of the MSF. The l-type amino acid transporters (LATs) are transporting neutral amino acids across the membrane.

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23

Gokh, A. F. "AUTISM: FACTORS OF UNREALIZED EXISTENCE." Bulletin of Krasnoyarsk State Pedagogical University named after V.P. Astafiev 62, no. 4 (2022): 183–91. http://dx.doi.org/10.25146/1995-0861-2022-62-4-378.

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Statement of the problem. The modern world promptly changes ideas of how the world is arranged. The phenomenon of autism, and earlier always mysterious, forces to rethink our representations and some dogmas. The purpose of the article is to reveal and prove possible omissions in historically developed approaches of escort of people with autism. Methodology. The research relies on a complete set of principles and methods of humanitarian and interdisciplinary research. The main principles to study the phenomenon of autism are a cultural and historical principle, a system principle and a principl

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De Souza, Ranyellen Félix, and Allyne De Almeida Ferreira Ramos. "A GESTÃO ESCOLAR NA EDUCAÇÃO DA REDE PÚBLICA ESTADUAL: o processo de escolha do gestor escolar em um estudo de caso na escola Professora Maria de Fátima Souto." Revista Principia - Divulgação Científica e Tecnológica do IFPB 1, no. 46 (2019): 133. http://dx.doi.org/10.18265/1517-03062015v1n46p133-144.

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School management is seen as a process rooted in Brazilian history education that carries within it school administration and the participation of the school community in this management. Thus, the present article has the objective of evaluating the process of school principal’s choice as a constituent part of democratic management, bearing in mind how this choice is being made in the state of Paraíba and how it is impacting the process of democratic management , specifically the reality of a school in the municipality of João Pessoa. Based on authors such as Lück (2009), Paro (2003) and the B

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Danilov, O. O. "Features of fender protection application on uncrewed port tugs." Vestnik Gosudarstvennogo universiteta morskogo i rechnogo flota imeni admirala S. O. Makarova 15, no. 3 (2023): 416–25. http://dx.doi.org/10.21821/2309-5180-2023-15-3-416-425.

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In this paper, the variants of the fender protection of traditional port tugs and the possibility of using this protection on unmanned vessels of such type are considered; the main elements of such protection are investigated. At present, the technical level of mechanisms, instruments and software allows creating unmanned and crewless vessels. One of the promising directions in the development of such vessels is port tugs, since having relatively large river and sea vessels they perform production tasks in the port water area and approaches to it. An integral part of the work of a port barthin

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Oliveira, Allan Chiaratti de, Amélia Miyashiro Nunes dos Santos, Ana Maria Martins, and Vânia D'Almeida. "Screening for inborn errors of metabolism among newborns with metabolic disturbance and/or neurological manifestations without determined cause." Sao Paulo Medical Journal 119, no. 5 (2001): 160–64. http://dx.doi.org/10.1590/s1516-31802001000500002.

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CONTEXT: Inborn Errors of Metabolism are hereditary affections resulting from incompetence in enzymatic reactions of intermediary metabolism. At present, several hundred hereditary metabolic disturbances are known, many of which correspond to severe life-threatening disorders. OBJECTIVE: The early detection of carriers has motivated the screening for these disturbances among newborns at the Neonatal Unit of Hospital São Paulo, in an attempt to initiate support treatment, when available, before clinical manifestations become evident. DESIGN: Prospective study of risk patients. SETTING: Laborato

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Guo, Chenxu, Sheng Sun, Nayana Thimmiah, et al. "Abstract 6582: HD-PTP modulates anti-tumor immunity via extracellular vesicles in triple-negative breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 6582. https://doi.org/10.1158/1538-7445.am2025-6582.

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Abstract The tumor immune microenvironment (TIME) is a critical driver for the progression of triple-negative breast cancer (TNBC), directly impacting patient prognosis and treatment response. One emerging mechanism underlying immune evasion in TNBC involves extracellular vesicles (EVs), which act as carriers of immunosuppressive factors (ISFs) that shape the immune landscape. Here, we identify HD-PTP, an ESCRT-associated protein encoded by the PTPN23 gene, as a key regulator of EV-mediated immune modulation. Clinically, we reveal that HD-PTP loss is frequently observed in TNBC and correlates

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de, Carvalho Leite José Carlos, and S.Souza Renata. "Os efeitos do apoio social na adesão ao tratamento antirretroviral: um estudo de coorte prospectiva." Revista Perspectiva: Ciência e Saúde 7, no. 1 (2022): 165–77. https://doi.org/10.5281/zenodo.13357530.

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Abstract The present study describes the membership and studying the effects of social support to this treatment; also investigates the extent to which other social, economic conditions, health and therapeutic influence on accession. 130 patients participated in the study of the SAE-Pittsford, carriers of the HIV virus, accompanied in a prospective cohort of 6 months, the first being data collection performed after a clinical evaluation (Time 0); and the second was held to assess the adherence to the treatment (Time 1). The percentage of membership was obtained in consultation with the medical

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Goncalves, Ivair Donizete, Margareth M. Cordeiro, and Zaira Barbara da Silva. "Anemia Falciforme e o Comprometimento da Aprendizagem em Crianças e Jovens no Período Escolar." Revista de Ensino, Educação e Ciências Humanas 19, no. 2 (2018): 245. http://dx.doi.org/10.17921/2447-8733.2018v19n2p245-251.

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A doença falciforme - DF é uma hemoglobinopatia que afeta a cadeia da hemoglobina presente nas hemácias. Os indivíduos portadores apresentam a forma homozigótica da cadeia S da hemoglobina denominada de HbSS. A DF é considerada um problema de saúde pública no Brasil por ser uma doença frequente, grave e associada à elevada taxa de letalidade, especialmente, entre os jovens durante a idade escolar. Este trabalho teve como objetivo avaliar o impacto da DF em crianças e adolescentes de 5 a 18 anos acompanhados no Hemocentro de Cuiabá-MT, no período escolar. Para a execução deste estudo foram sele

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BATISTA NETO, José. "Narrativas da trajetória escolar de um formador de professor: memória, história e formação." INTERRITÓRIOS 5, no. 9 (2019): 187. http://dx.doi.org/10.33052/inter.v5i9.243609.

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RESUMOA narrativa da trajetória escolar de formador de professores é trazida à luz como pretexto para discussão sobre a relevância de material biográfico em processos formativos. Práticas relacionadas ao método biográfico no cenário da escola de educação básica são aqui exploradas com a finalidade de evidenciar seu potencial formativo. A contextualização foi um recurso metodológico observado, tendo de seu uso resultado um texto recheado de notas históricas. A narrativa de trajetória escolar e do contexto de produção compõe aqui um memorial, entendido como um olhar lançado sobre a história de v

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Santos, Mayra Cristina Martins dos, Ana Camila Batista, and Ivandira Anselmo Ribeiro Simões. "Síndrome de down: facilidades, dificuldades e apoio encontrado pelos pais / Down syndrome: facilities, dificulties and support found by parents." REVISTA CIÊNCIAS EM SAÚDE 7, no. 2 (2017): 23–29. http://dx.doi.org/10.21876/rcsfmit.v7i2.660.

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Introdução: A síndrome de Down (SD) é um distúrbio genético, devido à presença adicional de um cromossomo 21 nas células de seu portador e que causa um retardo mental de vários graus. Objetivos: Identificar quais as dificuldades e facilidades que os pais tiveram na criação de seus filhos com a SD e conhecer que tipos de apoio os pais dos portadores da SD receberam. Métodos: Pesquisa do tipo qualitativa, descritiva e exploratória. Para a análise e interpretação dos dados utilizou-se a técnica do Discurso do Sujeito Coletivo, que tem como base as Teorias das Representações Sociais. O local do es

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Sivieri-Pereira, Helena De Ornellas, Dennis Gabiatti Lopes, and Nathália Beatriz Fontes Silva. "Diários de aula como estratégia de reflexão na formação e prática docente (Classroom diaries as a strategy for reflection on teacher education and practice)." Revista Eletrônica de Educação 14 (February 1, 2020): 3125052. http://dx.doi.org/10.14244/198271993125.

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This article is born from the results of a larger research that aimed to identify the relationship that the teacher establishes between his personal dimensions (identity) and the professional dimensions (teacher identity) in his formation and his practice, through reflection on his daily action. At this moment of the research the objective was to identify and describe the reflexive processes observed on the practical action of the teacher, as well as the paths covered in the formation and constitution of the professional identity. For this, the methodology of writing class diaries was used, ma

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González-Angulo, Pedro, María Magdalena Alonso-Castillo, Carla Aparecida Arena Ventura, Sandra Cristina Pillon, and Nora Angélica Armendáriz-García. "La dinámica familiar y el clima social escolar como factores protectores del consumo de alcohol en universitarios mexicanos." Enfermería Global 21, no. 4 (2022): 1–24. http://dx.doi.org/10.6018/eglobal.518421.

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Introduction: Alcohol consumption carries a heavy social and economic burden on society, government, overall health, and health systems. Objective: Determine the relationship and effect of family dynamics and school social environment on alcohol consumption in young university students.Methodology: This was a descriptive, correlational and predictive study with a sample of 367 undergraduate students from a university in the state of Tabasco, Mexico, selected by stratified random probability sampling. The 63.2% were women, with a mean age of 21.6 years (SD=2.82). A Personal Identity Card and Pr

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"william t. y'blood. The Little Giants: U.S. Escort Carriers against Japan. Annapolis, Md.: Naval Institute. 1987. Pp. xii, 468. $28.95." American Historical Review, February 1989. http://dx.doi.org/10.1086/ahr/94.1.237-a.

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Aliaksei, Ihnatsyeu-Kachan, Dzmitruk Volha, Apartsin Evgeny, et al. "Multi-Target Inhibition of Cancer Cell Growth by SiRNA Cocktails and 5-Fluorouracil Using Effective Piperidine-Terminated Phosphorus Dendrimers." November 13, 2017. https://doi.org/10.3390/colloids1010006.

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<strong>Abstract</strong> Currently, RNAi based approaches for cancer treatment involving short double stranded RNA molecules (siRNA) are under vigorous scrutinization. Due to numerous biological obstacles, siRNA delivery into target cells requires protective escort. On the other hand, combining of siRNA-mediated gene silencing and action of conventional chemotherapeutics can propose additional enhancement of anticancer activity. In the present study, we investigated a siRNA cocktail able to downregulate anti-apoptotic genes (BCL-xL, BCL-2, MCL-1) and the chemotherapeutic agent 5-flu

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Pannen, Hendrik, Tim Rapp, and Thomas Klein. "The ESCRT Machinery regulates Retromer dependent Transcytosis of Septate Junction Components in Drosophila." eLife 9 (December 30, 2020). http://dx.doi.org/10.7554/elife.61866.

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Loss of ESCRT function in Drosophila imaginal discs is known to cause neoplastic overgrowth fuelled by mis-regulation of signalling pathways. Its impact on junctional integrity, however, remains obscure. To dissect the events leading to neoplasia, we used transmission electron microscopy (TEM) on wing imaginal discs temporally depleted of the ESCRT-III core component Shrub. We find a specific requirement for Shrub in maintaining Septate Junction (SJ) integrity by transporting the Claudin Megatrachea (Mega) to the SJ. In absence of Shrub function, Mega is lost from the SJ and becomes trapped on

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Wakana, Yuichi, Kaito Hayashi, Takumi Nemoto, et al. "The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER–Golgi membrane contact sites." Journal of Cell Biology 220, no. 1 (2020). http://dx.doi.org/10.1083/jcb.202002150.

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In response to cholesterol deprivation, SCAP escorts SREBP transcription factors from the endoplasmic reticulum to the Golgi complex for their proteolytic activation, leading to gene expression for cholesterol synthesis and uptake. Here, we show that in cholesterol-fed cells, ER-localized SCAP interacts through Sac1 phosphatidylinositol 4-phosphate (PI4P) phosphatase with a VAP–OSBP complex, which mediates counter-transport of ER cholesterol and Golgi PI4P at ER–Golgi membrane contact sites (MCSs). SCAP knockdown inhibited the turnover of PI4P, perhaps due to a cholesterol transport defect, an

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Caldatto, Marlova Estela, Carlos Alexandre Ribeiro Martins, and José Carrillo Yanez. "Os exames de qualificação realizados no mestrado profissional em matemática em rede nacional." Educação e Pesquisa 49 (2023). http://dx.doi.org/10.1590/s1678-4634202349249650por.

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Resumo Analisa-se, neste artigo, a natureza dos conhecimentos, especialmente os de cunho especializado, evocados na resolução das questões que compuseram Exames Nacionais de Qualificação (ENQ), desenvolvidos no âmbito do Programa de Mestrado Profissional em Matemática em Rede Nacional (PROFMAT), entre os anos de 2012 e 2019. O foco nesse programa deu-se por pautar-se no desenvolvimento de uma sólida formação em Matemática, que contemple as necessidades provenientes do cotidiano dos professores no espaço da escola e de suas necessidades amplas de desenvolvimento e de valorização profissional. P

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Martini, Fanny, Coline Arone, Amy Hasset, William W. Hall, and Noreen Sheehy. "The ESCRT-0 Protein HRS Interacts with the Human T Cell Leukemia Virus Type 2 Antisense Protein APH-2 and Suppresses Viral Replication." Journal of Virology 94, no. 1 (2019). http://dx.doi.org/10.1128/jvi.01311-19.

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ABSTRACT The divergent clinical outcomes of human T cell leukemia virus type 1 (HTLV-1) and HTLV-2 infections have been attributed to functional differences in their antisense proteins. In contrast to HTLV-1 bZIP factor (HBZ), the role of the antisense protein of HTLV-2 (APH-2) in HTLV-2 infection is poorly understood. In previous studies, we identified the endosomal sorting complex required for transport 0 (ESCRT-0) subunit HRS as a novel interaction partner of APH-2 but not HBZ. HRS is a master regulator of endosomal protein sorting for lysosomal degradation and is hijacked by many viruses t

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Cao, Bowen, Johanna Valentina Dahlen, Merve Sen, et al. "Mutant dominant-negative rhodopsin∆I256 causes protein aggregates degraded via ERAD and prevents normal rhodopsin from proper membrane trafficking." Frontiers in Molecular Biosciences 11 (May 17, 2024). http://dx.doi.org/10.3389/fmolb.2024.1369000.

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Dominant mutations in the rhodopsin gene (Rho) contribute to 25% of autosomal dominant retinitis pigmentosa (adRP), characterized by photoreceptor loss and progressive blindness. One such mutation, Rho∆I256, carries a 3-bp deletion, resulting in the loss of one of two isoleucines at codons 255 and 256. Our investigation, using recombinant expression in HEK293 and COS-7 cells, revealed that Rho∆I256, akin to the known adRP mutation RhoP23H, induces the formation of rhodopsin protein (RHO) aggregates at the perinuclear region. Co-expression of Rho∆I256 or RhoP23H with wild-type RhoWT, mimicking

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Dogrammatzis, Christos, Shadia Saleh, Clayton Deighan, and Maria Kalamvoki. "Diverse populations of extracellular vesicles with opposite functions during herpes simplex virus 1 infection." Journal of Virology, December 23, 2020. http://dx.doi.org/10.1128/jvi.02357-20.

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Extracellular vesicles (EVs) are released by all types of cells as a means of intercellular communication. Their significance lies in the fact that they can alter recipient cells functions, despite their limited capacity for cargo. We have previously demonstrated that herpes simplex virus 1 (HSV-1) infection influences the cargo and functions of EVs released by infected cells, and that these EVs negatively impact a subsequent HSV-1 infection. In the present study, we have implemented cutting-edge technologies to further characterize EVs released during HSV-1 infection. We identified distinct E

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Ferreira, Maria Jucilene Lima, Antonia Euza Carneiro de Sousa, and José Romildo Pereira Lima. "Contributions from Trade-Off Pedagogy to Agriculture and Cattle Raising Technicians Training: the case of Escola Família Agrícola de Jaboticaba – Quixabeira - Bahia." Revista Brasileira de Educação do Campo, 2020, 1–27. http://dx.doi.org/10.20873/uft.rbec.e8573.

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Education is constituted and a constituent of a people's culture and social organization. Based on this assertion, we consider that the theoretical and methodological assumptions of Pedagogy of Alternation enable the construction and realization of educational processes in the perspective of human emancipation. In this understanding, this article aims to analyze contributions from Pedagogy of Alternation to the training of young peasants linked to the Escola Família Agrícola de Jaboticaba - Bahia (BA), in the High School Technical Education Course in Agriculture Integrated to High School. Alte

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Chen, Rui, Ziqin Kang, Wenhao Li та ін. "Extracellular vesicle surface display of αPD‐L1 and αCD3 antibodies via engineered late domain‐based scaffold to activate T‐cell anti‐tumor immunity". Journal of Extracellular Vesicles 13, № 7 (2024). http://dx.doi.org/10.1002/jev2.12490.

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AbstractExtracellular vesicles (EVs) are emerging as promising carriers for the delivery of therapeutic biologics. Genetic engineering represents a robust strategy for loading proteins of interest into EVs. Identification of EV‐enriched proteins facilitates protein cargo loading efficiency. Many EV‐enriched proteins are sorted into EVs via an endosomal sorting complex required for transport (ESCRT)‐dependent pathway. In parallel, viruses hijack this EV biosynthesis machinery via conserved late domain motifs to promote egress from host cells. Inspired by the similarity of biogenesis between EVs

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Clippinger, Amy K., Teresa V. Naismith, Wonjin Yoo, Silvia Jansen, David J. Kast, and Phyllis I. Hanson. "IST1 regulates select recycling pathways." Traffic, November 5, 2023. http://dx.doi.org/10.1111/tra.12921.

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AbstractESCRTs (Endosomal Sorting Complex Required for Transports) are a modular set of protein complexes with membrane remodeling activities that include the formation and release of intraluminal vesicles (ILVs) to generate multivesicular endosomes. While most of the 12 ESCRT‐III proteins are known to play roles in ILV formation, IST1 has been associated with a wider range of endosomal remodeling events. Here, we extend previous studies of IST1 function in endosomal trafficking and confirm that IST1, along with its binding partner CHMP1B, contributes to scission of early endosomal carriers. F

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De Freitas, Isaurora Cláudia Martins. "ESCOLA E ORGANIZAÇÃO NÃO GOVERNAMENTAL: educação formal e não-formal de jovens da periferia de Fortaleza." Caderno CRH 20, no. 49 (2007). http://dx.doi.org/10.9771/ccrh.v20i49.18858.

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Freqüentar uma ONG para ter acesso a atividades educativas destinadas a complementar a formação proporcionada pela escola formal passou a ser uma realidade na vida de muitos jovens desfavorecidos do Brasil, a partir dos anos 90, quando a promulgação do Estatuto da Criança e do Adolescente fez surgir grande número de projetos sociais destinados a garantir os direitos de cidadania de crianças e adolescentes consideradas em situação de risco ou vulnerabilidade social. A partir da reconstituição das trajetórias de sete jovens egressos da Escola de Dança e Integração Social para Crianças e Adolesce

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Jesus Neto, Antonio Gomes de. "A circulação interna de mercadorias no território moçambicano: um país sobre rodas." GeoTextos 13, no. 2 (2017). http://dx.doi.org/10.9771/1984-5537geo.v13i2.23319.

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Moçambique é historicamente conhecido por ser um território voltado ao seu exterior, tanto por escoar a produção da hinterland da África Austral (como seus vizinhos África do Sul, Suazilândia, Zimbabwe e Malawi), como pelo antigo direcionamento da economia do país para a exportação da produção interna. Ainda que o atual modelo dos chamados “mega projetos” continue a estimular essa lógica extravertida, desde a independência do país, em 1975, o governo moçambicano vem reunindo esforços na tentativa de integrar seu território e configurar uma economia eminentemente nacional. Tal tarefa cabe, no q

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Gómez Hurtado, Inmaculada. "El Equipo Directivo como Promotor de Buenas Prácticas para la Justicia Social: Hacia un Liderazgo Inclusivo." Revista Internacional de Educación para la Justicia Social 3, no. 2 (2014). http://dx.doi.org/10.15366/riejs2014.3.2.007.

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El presente artículo describe parte una investigación cualitativa realizada un centro de Educación Infantil y Primaria considerado como promotor de buenas prácticas para la justicia social desde un enfoque inclusivo. Para ello, hemos realizado un estudio de caso en dicho centro utilizando como instrumentos las entrevistas, observaciones y análisis de documentos teniendo como objetivo analizar, describir, contrastar e interpretar la gestión de la diversidad y las buenas prácticas directivas inclusivas del equipo directivo de un centro público de Educación Infantil y Primaria de la capital de Hu

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Biagini, Jussara, Fabiana Sabará Dias, and Kamilla Veronezi Martins. "O PROJETO CURRICULAR DE UMA INSTITUIÇÃO DE EDUCAÇÃO PROFISSIONAL TÉCNICA DE NÍVEL MÉDIO NA PERSPECTIVA DO ALUNO (THE CURRICULUM OF A HIGH-SCHOOL LEVEL INSTITUTION OF TECHNICAL EDUCATION IN THE STUDENTS' PERSPECTIVE) - Doi: 10.5212/OlharProfr.v.11i2.339354." Olhar de Professor 11, no. 2 (2009). http://dx.doi.org/10.5212/olharprofr.v.11.1527.

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O objetivo deste estudo é analisar as percepções de um grupo de alunos a respeito do projeto curricular de uma Instituição de Educação Profissional Técnica de Nível Médio. As análises se baseiam nas informações e nos dados extraídos do “Questionário Individual de Avaliação Institucional/Concomitância Externa” respondidos pelos alunos, nos anos 2005-2006. Destaca-se que os sujeitos envolvidos no processo investigativo cursaram somente a profissionalização técnica de nível médio na Instituição. Esses sujeitos são portadores de diploma de técnico de nível médio em uma Instituição pública de quali

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"Optimización de rutas de vehículos con enfoque multiobjetivo mediante Sistema Basado en Colonia de Hormigas en una Empresa de transporte de Personal." Revista ECIPeru, December 10, 2018, 5–12. http://dx.doi.org/10.33017/reveciperu2017.0001/.

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Optimización de rutas de vehículos con enfoque multiobjetivo mediante Sistema Basado en Colonia de Hormigas en una Empresa de transporte de Personal John P. Portella Melchor, Carool E. Tomasto Farfan, Hugo F. Vega Huerta, Zoraida Mamani Rodríguez Facultad de Ingeniería de Sistemas e Informática, Universidad Nacional Mayor de San Marcos, Lima, Perú Recibido el 15 de junio del 2017. Revisado el 21 de junio del 2017. Aceptado el 1 de julio del 2017 DOI: https://doi.org/10.33017/RevECIPeru2017.0001/ Resumen El presente proyecto tiene como objetivo mejorar la planificación de rutas mediante la dism

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Reid, Christy. "Journey of a Deaf-Blind Woman." M/C Journal 13, no. 3 (2010). http://dx.doi.org/10.5204/mcj.264.

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I sat alone on the beach under the shade of a big umbrella. My husband, Bill, and our three children were in the condo taking a break from the Florida sunshine. Dreamily, I gazed at the vast Gulf of Mexico, the brilliant blue sky stretching endlessly above. I was sitting about 50 feet from the surf, but I couldn't actually see the waves hitting the beach; I was almost blind. It was a windy day in late May and I loved feeling the ocean breeze sweeping over me. I imagined I could hear the waves crashing onto the surf, but the sound was only a memory. I was totally deaf. Although I had a cochlear

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