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Dissertations / Theses on the topic 'ESDM'
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1
Doktor, Christopher A. "Development of a statistical method for validating ESDM strain-field output." Thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-01242009-063032/.
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Stafne, Michael Allan. "An Experimental Evaluation of the Experimental Spatial Dynamics Modeling (ESDM) Technique." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/46492.
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Relatively new transducers permit the measurement of dynamic response at many structure locations. Included among such transducers is the scanning laser Doppler vibrometer (LDV). A scanning LDV can measure velocity at many structure locations. An important new technique, Experimental Spatial Dynamics Modeling (ESDM), utilizes such spatially dense velocity data. ESDM models continuous, three-dimensional velocity fields using LDV velocity data. Thus, ESDM is a powerful structural dynamics analysis tool that significantly enhances the usefulness of a scanning LDV. However, heretofore, ESDM has not been experimentally evaluated. The results contained herein partially satisfy this need. Specifically, this research evaluated the ability of ESDM to reconstruct velocity response fields with large in-plane components parallel to a surface in the presence of small out-of-plane components transverse to the surface. To fulfill this objective, a test structure was developed and fabricated; the structure had certain dynamic properties which aided ESDM evaluation. Subsequently, the test structure was harmonically excited at a single frequency such that large in-plane and small out-of-plane velocity components were present on a particular surface. LDV and accelerometer data were then collected. Ultimately, velocity results were obtained from the LDV data via ESDM and the accelerometer data. Velocity results derived from the accelerometer data served as an experimental standard against which ESDM results were compared. Result comparisons clearly indicate that ESDM accurately reconstructs surface velocity fields with large in-plane and small out-of-plane components.Master of Science
3
Zhuang, Lihui. "Mechanisms of microenvironmental conditioning in non-Hodgkin's lymphoma." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6486.
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Tumours are not autonomous transformed cell populations, but rather a society composed of both malignant and normal, including immune, cells that together foster tumour growth and development. Tumour-associated macrophages have been reported to enhance tumour growth, progression and metastasis. In high-grade non-Hodgkin’s lymphomas, prototypically the B-cell neoplasm, Burkitt’s lymphoma (BL), infiltrating macrophages engulf large numbers of apoptotic tumour cells. Evidence suggests that apoptotic BL cells can condition the tumour microenvironment to promote lymphoma development by selectively attracting macrophages while inhibiting neutrophil infiltration and by stimulating macrophages to produce the B-cell growth and survival factor. Tumour cells grow in a hypoxic and nutrient-deficient environment and the resultant cellular stress can induce apoptosis. It is therefore possible that hostile environmental conditions in the tumour also contribute to the generation of a pro-tumour microenvironment. This thesis describes investigations which examined this hypothesis. BL cells were cultured at high density to mimic conditions of metabolic stress existing in the tumour environment. Cell-free supernatants from such stressed BL cells demonstrated potent chemoattractive activity for mononuclear phagocytes. Supernatants from BL cells that were protected from apoptosis by over-expression of bcl-2 had similar ability, confirming that chemoattractant release was apoptosis-independent. The observation that apyrase and suramin could inhibit the chemotactic activity of these supernatants suggested that nucleotides might be the apoptosis-independent chemoattractant. Detection of ATP in stress supernatants by bioluminescence assay was consistent with this proposal. Significantly, supernatants from BL cells and those transfected with bcl-2 were both found to inhibit neutrophil migration, suggesting the occurrence of a neutrophil migration inhibitory factor whose release was apoptosis-independent. Furthermore, stress supernatants could promote BL cell proliferation in vitro, which was apoptosis and cell line-independent. In order to study the role of TAM in the tumour microenvironment, a novel macrophage model was devised using mouse embryonic stem cells (ES cells). Cells derived from ES cells generated in vitro expressed macrophage-specific markers and were free of dendritic cells and undifferentiated ES cells. ES cell-derived macrophages (ESDM) could migrate towards apoptotic BL cells and engulf them. However, ESDM migrated to stress supernatants with decreasing efficiency as they matured. Preliminary data indicated that the phagocytic ability of ESDM to engulf apoptotic cells increased as they matured, consistent with distinct roles for circulating monocytes and tissue macrophages with regard to this function. Considering the high yields and purities of ESDM described here, together with their non-malignant nature and genetic versatility these cells should provide a superior source of undifferentiated mononuclear phagocytes with which to elucidate the molecular mechanisms underlying tumour infiltration and microenvironmental conditioning by TAM. In conclusion, this work suggests that under conditions of pre-apoptotic stress, BL cells have the capacity to regulate their micro-environment upstream of their apoptosis programme to promote net tumour growth through paracrine signals that attract supportive macrophages and inhibit destructive neutrophils and through release of autocrine/juxtacrine tumour growth factors.
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Alexis, Engström. "Utbildning och hållbar utveckling : En studie av innehåll och normativitet i utsagor om hållbar utveckling i utbildningssammanhang." Thesis, Uppsala universitet, Institutionen för pedagogik, didaktik och utbildningsstudier, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233150.
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Inom utbildning och hållbar utveckling pågår en debatt om det är utbildningensroll att främja enskilda beteenden som av experter definieras som hållbara. Åsikterna kan delas upp i utbildning förhållbar utveckling och utbildning somhållbar utveckling, där den senare är skeptisk till experters förmåga att säkert veta om ett beteende är mer hållbartän ett annat och iställetförespråkar en pluralistisk och kritisk ingång där självständigt tänkande premieras. Valet mellan att främja eller attarbeta kritiskt mednormer har i denna uppsats sammanfattats underdilemmat med normativitet.Studienbestår av två delar: Den första undersöker vilket innehåll som ges till utbildning och hållbar utveckling i utsagor från utbildningsansvariga för lärarprogrammet vid Uppsala Universitet. Den andra undersöker hur innehålleti utbildning och hållbarutvecklingförhåller sig till dilemmat med normativitet som nämns ovan.De slutsatser som kan dras utifrånundersökningen äratt innehållet som detframkommer i utsagornakan sammanfattas i fem olika teman samtatt de temanahar mycket gemensamt med resultatfråntidigare studier. Det visar på att det har börjatväxa fram en ram för vad hållbar utveckling i utbildningssammanhang kan ges för innehåll. I utsagorna framkom även innehåll som skiljer sig från tidigare forskning, t.ex. att utgå från utbildning och hållbarutveckling som en tydlig kompetens kring vilken studenter kan specialisera sig utifrån framtida arbetstillfällen, samt att studenter i större grad kan påverka innehållet, och ansvara för formerna, isin egen utbildning. Resultatet visar även att utbildningen kan utformas på ett sätt som är både normativtoch pluralistiskt. Genom att ha en medveten ingång till i vilket sammanhang fakta omhållbara beteenden presenteras, kan studenterna ges en position där de själva har möjlighet att övervaka överförandet av normer. Genom detta tillsammans med ett diskussionsklimat där läraren är i bakgrunden och låter studenterna själva identifiera ohållbara utvecklingar och värden som ska bevaras,undviksobalanseni makt mellan läraren och studenterna och ett pluralistiskt utbildningsklimat skapas.
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Sarikamis, Asligul. "The Eu-nato Relations In The Post-cold War European Security: Cohabitation Or Separation?" Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/2/12605094/index.pdf.
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This thesis aims at analyzing the EU&rsquos quest for autonomous defence vis-à
-vis NATO with a special reference to the ESDP. The major research question asked is what kind of relationship exists between the EU and NATO. Accordingly, the argument is that the EU&rsquo
s desire to gain autonomy through the ESDP is unlikely to pose a threat to the primacy of NATO in European Security. In this framework, firstly, the legacy of the Cold War and transition from the ESDI to the ESDP are discussed. Secondly, the political aspect of the EU-NATO relations is addressed by touching upon the views of major powers in the EU-NATO relations. The main obstacles for the development of the EU-NATO relations are explored in the third part. The last part is allocated to the recent developments in the EU-NATO relations within the post September 11 context. This thesis is concluded by suggesting that although the evolving nature of the EU-NATO relations does not provide sufficient evidence for giving a clear answer to whether the EU and NATO cohabitate or separate, the EU and NATO should strive for cohabitating and working together in a complementary and harmonious way.
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Küchler, Julia. "Elektronische Semesterapparate (ESEM)." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1156335295183-75146.
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Lin, Chorng-Yau. "The 'Blair initiative' and the development of ESDI/ESDP : continuity and change in British post-Cold War foreign policy towards European security and defence cooperation, 1989-2000." Thesis, University of Sussex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441629.
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Matějka, Milan. "Pozorování izolantů v ESEM." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217628.
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This graduation theses in introduction deals with principle and problems of electron signal detection in scanning electron microscopy and charging of insulating specimens in SEM. The experimental part of the thesis describe the methods of qualification and quantification of insulating specimen charging effect observed in environmental scanning electron microscope through the use of ionisation and scintillation detector in dependence on water vapour pressure in specimen chamber. The goal of the thesis is formation of the methodics useful to evaluate charging effect at insulating specimens observing and on the basis of measuring, determine optimal conditions for insulating specimen observation with ionisation and scintillation detector.
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Pokluda, Tomáš. "Ionizační detektor pro ESEM." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2013. http://www.nusl.cz/ntk/nusl-220106.
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This thesis is focused on the environmental scanning electron microscopes including a description of the basic physical mechanisms. It describes the design and realization of the electrode ionization detector system suitable for the detection of signal electrons with a greater proportion of secondary electrons. It also deals with simulations of trajectories of electrons in the electrostatic field of the detector, and with verification of the functionality of the detector in the environment of water vapors in the specimen chamber of the electron microscope.
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Bay, Till G. "Eiffel SDL multimedia library (ESDL)." Zürich : ETH, Eidgenössische Technische Hochschule Zürich, Professur für Software Engineering /Chair of Software Engineering, 2003. http://e-collection.ethbib.ethz.ch/show?type=dipl&nr=195.
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Buchta, Michal. "Metoda napěťového kontrastu v ESEM." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217627.
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This graduation thesis deals with the problem of voltage contrast in ESEM. The purpose of this work was to verify influence of used detectors in the dependence on conditions in specimen chamber on the size of voltage contrast. With the conditions in specimen chamber we understand pressure and working conditions of signal detection. We used power transistor as specimen.
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Soldner, Wolfgang Wilhelm. "HF-ESD-Codesign." Aachen Shaker, 2009. http://d-nb.info/996579168/04.
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Vahidian, Elaheh. "Evolution of the SIM to eSIM." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for telematikk, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-20736.
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Abstract Every GSM (Global System for Mobile Communications) phone, also called 2G mobile phone and every UMTS (Universal Mobile Telecommunications System) phone, aka 3G mobile phone requires a smart card to connect and function in the mobile network. This smart card is called SIM, which stands for Subscriber Identity Module. In fact, this module contains the International Mobile Subscriber Identity (IMSI) and credentials that are necessary for the identification and authentication of the subscriber. Without the SIM the user will not be allowed to connect to the mobile network and hence not able to make or receive phone calls. As a smart card the SIM is a tampered resistant microprocessor card with its own operating system, storage and built-in security features that prevent unauthorized individual to access, retrieve, copy or modify the subscriber IMSI and credentials. Abuses of subscriber’s account and fraudulent accesses to the mobile network can hence be avoided. Furthermore, as a removable and autonomous module the SIM introduces great flexibility since the user can easily move the SIM to other mobile phones or replace a SIM with another one. So far, the smart card and its content, the SIM are bound together and called SIM. With the advances in wireless and storage technology, new demands have arisen. Because of cumbersome task of opening machines and installing the removable SIM, the M2M applications are designed with pre-installed SIM application. The M2M applications based on the cellular networks with the ability of installing the user subscription have advantages and disadvantages for a certain stakeholder. This master’s thesis provides the multiple alternative solutions to this installation and also describe the SIM evolutions i.e. eUICC and soft SIM to give a comprehensive view of the SIM’s situation. The thesis also presents the security assessment of these evolutions which are different with the current removable SIM.
14
Giegerich, Bastian. "National policies toward ESDP : 1999-2003." Thesis, London School of Economics and Political Science (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430420.
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Čudek, Pavel. "Scintilační detektor sekundárních elektronů pro ESEM." Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2016. http://www.nusl.cz/ntk/nusl-234652.
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The thesis deals with the scintillation secondary electron detector for environmental scanning electron microscope, its design and construction. The starting point was numerical simulation of electrostatic fields and electron trajectories in the electrode system of the detector and simulation of pressure distribution and flow of gases in different parts of the detector. On the basis of modeling and simulation, construction changes of the detector were gradually implemented. Detection efficiency of each version of the detector was determined by the method described in the work. This method enables to evaluate signal level from the captured images of the specimen, quality of images was stated from signal to noise ratio. The thesis describes the whole process of the detector improvement from initial state, when the detector operated with lower efficiency in the pressure range from 300 to 900 Pa, to final version that enables usage of the detector in the range from vacuum up to 1000 Pa of water vapors in the specimen chamber of the microscope.
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Čudek, Pavel. "Scintilační detektor sekundárních elektronů pro ESEM." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217739.
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The thesis deals with modifying and biulding of scintilation detector of secondary electrons for environmental scanning electron microscopy. It describes dilemma of environmental scanning electron microscopy, types of detectors and secondary electrons detection. The experimental part of this thesis focuses on the design and construction of new scintillation detector on the basis of simulations secondary electrons trajectories. Identifying the parameters, pressure dependencies and optimizations of electrode system of the detector realized.
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Drüen, Stephan [Verfasser]. "Virtual ESD Test – : An ESD Analysis Methodology at Chip Level / Stephan Drüen." Aachen : Shaker, 2007. http://d-nb.info/1166508595/34.
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Rodt, Annemarie Peen. "Success? : ESDP military conflict management operations : 2003-2009." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/11431/.
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From 2003 to 2009, the EU launched five military conflict management operations within the framework of the European Security and Defence Policy. This thesis examines their success. To this end, the thesis develops a definition and a set of criteria for success. It applies this theoretical framework in an empirical case study of success in the five EU operations, which were undertaken in Macedonia, Bosnia and Herzegovina, the Democratic Republic of Congo, Chad and the Central African Republic. Having established the level and nature of their success, the thesis goes on to examine the conditions under which ESDP military conflict management operations can be successful. The key finding of the research is that for an operation of this nature to succeed, it is necessary that it secures sufficient support internally, within the EU, and externally, outside the EU, from domestic, regional and international actors involved in the conflict and its management.
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Rosero, Oswaldo R. "Naval airborne ESM system analysis." Thesis, Monterey, California. Naval Postgraduate School, 1989. http://hdl.handle.net/10945/27150.
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Lianos, Paraschos. "European strategic culture : assessing the ESDP years (1998-2005)." Thesis, University of Leicester, 2008. http://hdl.handle.net/2381/8892.
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The central aim of this thesis is to analyse the distinct elements of a potential European strategic culture and their representation in the rhetoric and strategic actions of the Union, with special emphasis in the years of ESDP existence (1998-2005). The discussion rests on the proposition that a common European Strategic culture exists, albeit it is restricted in scope and depth. It is argued that as such, it is associated with three main pillars: humanitarian intervention, outward orientation and the pursuit of the largest possible consensus, i.e. multilateralism. The final objective of the discussion is to test these pillars against the proposition for the existence of a specific, albeit limited European strategic culture. It has been deemed that the most productive way to determine whether the three pillars of European strategic culture can be considered realistically relevant is to assess them against the rhetoric and strategic actions of the European Union that took place within the period 1998-2005, which is the set timeframe for this thesis. Following an up-to-date literature review on the subject (Chapter II), this thesis makes use of a modified framework by Booth and Macmillan in order to explore those parameters that influence the development of strategic culture, such as geography, history and political structures. The modified framework is outlined and discussed in Chapter III. Chapter IV serves to put the concept of a European strategic culture in its historical context. Important milestones in EEC/EU defence history since the need for a common defence was articulated in the 1950s are analysed. The emphasis lays not so much on the origins of common defence and foreign policy initiatives but on recent developments. Chapter V introduces facets of strategic culture as these can be revealed through the rhetoric of the EU. The focus is on those documents that best describe the strategic concept of the EU after the introduction of the ESDP and more specifically, the European Security Strategy (ESS). Chapter VI focuses on EU actions of strategic importance. In this respect, the three EU military operations that took place between the introduction of the ESDP in 1998 and the year 2005, (Operation Concordia, Artemis and Althea are examined). In conclusion, this thesis demonstrates the existence of a European strategic culture, but also confirms the initial proposition regarding the current nature of this strategic culture, which is limited in scope and in depth. As such, it is shown that it is based on the three pillars outlined in the proposition, i.e. humanitarian intervention, outward orientation and multilateralism.
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Krutil, Vojtěch. "Kryogenní cela pro studium vodního ledu v mikroskopu ESEM." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-417097.
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The presented thesis focuses on designing a cryogenic cell for the study of water ice in an environmental scanning electron microscope (ESEM). This cell allows the study ice in the temperature range 80 K – 300 K in a nitrogen gas environment with a pressure of up to 400 Pa. The cell is cooled by a flow cooling system, where liquid or gaseous nitrogen is used as a refrigerant. The cell consists of a double-walled vessel with vacuum insulation, a flow-through heat exchanger, a sample well, and a cooled cell lid. The heat exchanger was designed to be able to dissipate the heat load at the level of 1 W. The exchanger is equipped with an electric resistance heater with an output of approximately 60 W, enabling heating of the sample at speeds of up to 100 K·min-1. The design also includes an LN2 gateway located on the door of the vacuum chamber of the microscope, to which the capillaries of the heat exchanger for the intake and outlet of refrigerant are connected. During the experimental verification of the cryogenic cell in the test vacuum chamber with a pressure of GN2 ~ 400 Pa, the limit temperature of 77.5 K on the sample well was reached.
22
Cheng, Ming-Jen. "Intermodulation in channelized digital ESM receivers." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1996. http://handle.dtic.mil/100.2/ADA320554.
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Thesis (M.S. in Systems Engineering) Naval Postgraduate School, September 1996.Thesis advisor(s): D.C. Schleher. "Septembeer 1996." Includes bibliographical references (p. 49). Also available online.
23
Soldner, Wolfgang W. [Verfasser]. "HF ESD CODESIGN / Wolfgang W Soldner." Aachen : Shaker, 2009. http://d-nb.info/1159834857/34.
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Mercer, P. R. "Airborne ESM receivers : techniques and technologies." Thesis, Loughborough University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.232818.
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Schröter, Felix [Verfasser]. "Flüssigkeitsbrücken und Selbstorganisation in zweidimensionalen Partikelsystemen im ESEM / Felix Schröter." Aachen : Shaker, 2016. http://d-nb.info/1118259203/34.
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Bache, I. C. "The development of ESEM and its application to food systems." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596233.
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The Environmental Scanning Electron Microscope (ESEM) is a new form of Scanning Electron Microscope (SEM) which supports a gaseous atmosphere and the presence of liquid water in the sample chamber. This opens up new possibilities for the use of ESEM to study many biological and food based systems which previously could not be satisfactorily studied using SEM. This thesis describes work carried out to understand the interactions between electrons and the water vapour present in the sample chamber, and examples of the use of ESEM to study two food based systems. The presence of gas in the chamber necessitates the use of a different type of electron detector than that used in conventional SEM. This detector utilises the gas in the chamber to amplify the electron signal. Previous descriptions of this amplification system have been found to be inadequate. A computer model was developed to simulate the behaviour of electrons as they are amplified through the gas, and an improved model suggested. The computer model was then applied to two other areas of electron interactions which were previously poorly described: the interactions of the high energy beam electrons with the gas, and the interactions of the signal electrons with condensed water. To illustrate the usefulness of the ESEM in studying food based systems, two examples were studied in detail. The gluten component of bread dough has interesting visco-elastic properties, and an attempt to study the development of its structure using ESEM was made. The mixture of gelatin and dextran in aqueous solution undergoes phase separation and gelation on cooling, and its final structure was studied using ESEM, as an example of a system that cannot be examined using conventional SEM.
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Staniewicz, Lech Thomas Leif. "Transmission-mode imaging in the environmental scanning electron microscope (ESEM." Thesis, University of Cambridge, 2012. https://www.repository.cam.ac.uk/handle/1810/242281.
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Electron microscopy was first conducted in the 1930s with the advent of theTEM and later the STEM. In 1969, the first commercial SEM was released,with the possibility of retrofitting it to behave like a STEM following soonafterwards. In 1979, Danilatos and Robinson advanced electron microscopyby creating a new type of SEM which allowed a controlled quantity of gasinto the sample chamber, termed ESEM. The most recent evolution in thisline was the combination of ESEM and STEM in 2005, a procedure termedWet STEM.The focus of this work is on investigating applications of this new technique,along with the contrast mechanisms involved in forming an image. Tothat end, a wide variety of samples will be imaged. Clay and paint suspensions(colloids) are used to test Wet STEM’s capacity to image submergedobjects, as well as thin objects which are stacked together. Diblock copolymerfilms are used to test Wet STEM’s ability to distinguish chemically similarmaterials without staining, the physical effects of heavy metal staining andto demonstrate the necessity of gas for the purpose of charge neutralisation. Single cell biological samples are also investigated. Internal contrast inmammalian cells is visible without recourse to staining, but chemical fixationis required despite maintaining a high relative humidity. Bacteria are moreresilient and as such are easier to image than animal cells, requiring no priortreatment. When exposed to low relative humidity, bacteria are found tocollapse. The collapse pattern is observed to differ between wild-type andcytoskeletal-deficient bacteria of the same species and strain, so it is likelythat dehydration-induced collapse offers information about the position andshape of the bacterial cytoskeleton.
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Bruehmann, Timo, Sabrina Florkowski, and Kevin Ickes. "Implementation of the ESDP : the example of North West Europe." Thesis, Blekinge Tekniska Högskola, Sektionen för teknokultur, humaniora och samhällsbyggnad, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-5105.
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The Thesis examines the implementation of the ESDP in the planning systems of North West Europe (Denmark, North Germany, Netherlands). For that it shows the influence of the ESDP on programmes and policies in the respective planning system, and also provides ideas to improve the interaction.
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Chung, Youngeun. "Education for Sustainable Development (ESD) in Sweden: A study of ESD within a transition affected by PISA reports." Thesis, Uppsala universitet, Institutionen för geovetenskaper, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210157.
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Education for Sustainable Development (ESD) has been called for playing a crucial role in integrating principles,values, and practices accorded with sustainable development. Holistic approach, ethical values, norm transitionand behavior changes are required to achieve the aim of ESD. However, while both external and internal impactsof the Swedish education system have affected its fundamental values and aims, core elements of ESD inSwedish curriculum were also influenced. This paper analyzes, in particular, the changes that PISA reportsbrought in the Swedish curriculum at the discourse level, and its potential effects on ESD. Discourse analysiswas mainly used for comparing two curricula and two syllabi. With the help of situational contexts of PISA andthe curriculum of 2011, a transition observed from text analysis was interpreted and the final discussion wasanchored with social contexts from educational discourses. The result indicated that influences from PISA in thenew curriculum and syllabus were observed in corresponded aims and goals. Situational and social contexts alsopointed to the same direction of transition due to the previous goals-oriented curriculum that made a wide rangeof teaching. Thus, fundamental values, aims and goals were changed into providing clearer guidelines forteaching scope and gradings as well as into focusing literacy skills and knowledge of concepts. In the process ofthe transition, holistic approach, ethical and democratical values, as well as focus on cultural aspects and pupils’ attributes were removed or shrunken, which implied negative impacts on ESD. On the other hand, emphasis onliteracy skills of students in the new curriculum was expected to bring positive achievement for ESD.Furthermore, in order to achieve the norm transition toward sustainable development, those lost immeasurable values are suggested to be addressed in future Swedish education.
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Zupac, Dragan 1961. "ESD-induced noncatastrophic damage in power MOSFETs." Thesis, The University of Arizona, 1990. http://hdl.handle.net/10150/291470.
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Electrostatic discharge (ESD) may, depending on the energy of the pulse, cause either catastrophic failures or degradation of MOSFETs. Effects of noncatastrophic positive Human-Body Model (HBM) ESD stress at the gate of power MOSFETs are investigated in this work. Noncatastrophic damage is manifested in the form of positive charge trapping in the gate oxide. In p-channel devices used in this study, the charge injection and trapping occur predominantly in the gate oxide areas lying above the p-body region. In p-channel devices used, the charge is injected mainly from the p-drain region. Based on the polarity of the pulse and the regions observed to contribute to charge injection, a model of ESD-induced charge injection from the silicon into the oxide is proposed. Finally, the effects of noncatastrophic ESD events on the radiation response of n-channel power MOSFETs are reported.
31
Dukhan, Al-Hytham, and Dastan Hassan. "Undersökning av alternativa ESD-skydd inom produktion." Thesis, Högskolan i Skövde, Institutionen för ingenjörsvetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19657.
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Tillverkning av elektroniska produkter ökar och utvecklas vilket medför till att flera skyddsåtgärder behöver vidtas under tillverkningsprocessen. Elektroniska komponenter kan skadas av elektrostatisk urladdning (ESD). Elektroniktillverkande industrier vill minimera ESD-risken inom produktionsmiljön för att minimera skaderisken i samband med produkterna. Företag använder sig av skyddsåtgärd i form av olika ESD-skyddssystem vilket bidrar till en ESD-kontrollerad produktionsmiljö. Ett projekt har utförts på företaget Veoneer, projektet bygger på en undersökning av det nuvarande ESD-systemet samt en undersökning av två alternativa ESD-skyddssystem. Vetenskapliga artiklar baserat på tre olika ESD-skyddssystem har undersökts för att evaluera kostnaderna och implementationsmöjligheten i produktionen. Undersökningen användes för att utvärdera neutraliseringseffektiviteten av den statiska uppladdningen. De undersökta ESD-skyddssystemen är följande ESD-emballagen som används i nuläget, ersättning av ESD-plast till enbart plast i samband med jonisatorer och slutligen justering av luftfuktigheten. Det nuvarande ESD-systemet skyddar produktionen från elektrostatiska urladdningar. Problemet med systemet är det höga priset för ESD-emballagen. Projektstyrningen baseras på tillvägagångsättet projekt base, projektstyrningsmetoden består av följande fyra stadier förstudier, planering, genomförande och avslut. Den nuvarande ESD-systemet och jonisator systemet undersöktes genom forskningsstudier och experiment. Justering av luftfuktigheten undersöktes enbart via litteraturstudier samt via företagsrapporter. För att möjliggöra experimenten anordnades mätverktyg för att uppmäta den elektrostatiska uppladdningen av ESD-emballagen samt plastemballagen. Jonisatorer implementerades inför slutexperimentet för att uppmätta den elektrostatiska neutraliseringsförmågan. Ekonomiska kalkyler av ESD-plastemballagen har utformats i samband med jonisatorer och plastemballage för att fastställa prisskillnaden mellan ESD-skyddssystemen. Experimentet bidrog till säkra och godkända mätvärden vilket medför ur ett experimentperspektiv till att jonisator systemet och det nuvarande system inte utsätter produkterna för någon ESD-risk. Införandet av jonisatorer leder till en stor ekonomisk besparing om lösningen skulle tillämpas som ersättningsalternativ. Jonisatorn bör inte implementeras direkt, fler utförliga studier behöver åstadkommas innan ett nytt ESD-system införskaffas. Företagets luftfuktighetsstudier påvisade negativa resultat vilket medförde till att inga fysiska luftfuktighetsexperiment kunde verkställas på företaget. Flera förbättringsförslag har åstadkommits i samband med nulägets ESD-skyddssystem och jonisator systemet. Förbättringsförslagen innefattar materialbyte ur ett ekonomiskt och ekologiskt hållbarhetsperspektiv samt har förslag på arbetsstandarden åstadkommits.As time goes on, the manufacturing of electronic products is increasing and evolving, which calls for the introduction of protective measures on electronic components. Electronic components can be problematic as they produce electrostatic discharge (ESD), something that the manufacturing industry aims to reduce. By implementing safety measures in various ESD-protective systems, which leads to a minimized risk of ESD damage. A project has been carried out at the company Veoneer, the project is based on a study regarding the current ESD-system and a study on two other ESD-protection systems. Literature study and experimentation have been accomplished in relation to the three ESD-protective systems to evaluate the costs and implementation possibilities of production and to further evaluate the effectiveness of neutralization of the static charge. The following ESD-protective systems examined are the currently using ESD-packaging, replacement of ESD-plastic to plastic trays only in combination with ionizers and finally adjustment of the relative humidity. The current ESD-system protects production from electrostatic discharges. The problem with the current system is the costly price ratio of the ESD-packaging. Veoneer carried out a project based on a study regarding the current ESD-system and a study on two other ESD-protective systems. Through the study of relevant literature and experimentation, the three ESD-protective systems have been analyzed to evaluate the costs and implementation possibilities of production and further evaluate the static charge's effectiveness of neutralization. The following ESD-protective systems currently use ESD-packaging, replacement of ESD-plastic trays to plastic trays with ionizers, and finally, adjusting the relative humidity. On the one hand, the current ESD-system protects production from electrostatic discharges, but the current system's problem is the costly price ratio of the ESD-packaging. Project management is centered around the project-based approach. The project-management method consists of four stages of feasibility: studies, planning, implementation, and closure. The control methodology has ensured that the project runs smoothly. The current ESD and ionizer systems were investigated through research studies and experiments, whereas adjustment of humidity was investigated solely through literature studies and company reports. To begin the experiments, measuring tools were arranged to calculate the electrostatic charge in regards to the ESD-packaging and the plastic packaging. Ionizers were utilized for the final experiment to measure the electrostatic neutralization capacity with plastic packaging. Economic calculations have been carried out by the ESD-plastic packaging in conjunction with ionizers and discovered that plastic packaging alone can determine the price difference between the ESD-systems. The experiment resulted in safe and approved readings, meaning that from an experimental perspective, the ionizer system and the current system do not expose products to any ESD-risk. The introduction of ionizers could lead to huge savings if they were to be used as a replacement option. The ionizer should not be implemented directly; more detailed studies need to be carried out before a new ESD-system is acquired. The company's humidity studies showed negative results, implying that the company could not carry out physical experiments concerning humidity. Several proposed improvements have been suggested regarding the current ESD-protection and ionizer system. The improvement proposals includes change of material from an economic and ecological sustainability perspective, and several proposals havebeen made regarding the working standards.
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Muthukrishnan, Swaminathan. "ESD Protected SiGe HBT RFIC Power Amplifiers." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/31705.
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Over the last few decades, the susceptibility of integrated circuits to electrostatic discharge (ESD) induced damages has justified the use of dedicated on-chip protection circuits. Design of robust protection circuits remains a challenging task because ESD failure mechanisms have become more acute as device dimensions continue to shrink. A lack of understanding of the ESD phenomena coupled with the increased sensitivity of smaller devices and time-to-market demands has led to a trial-and-error approach to ESD-protected circuit design. Improved analysis capabilities and a systematic design approach are essential to accomplish the challenging task of providing adequate protection to core circuit(s).
The design of ESD protection circuitry for RFIC's has been relatively slow to evolve, compared to their digital counterparts, and is now emerging as a new design challenge in RF and high-speed mixed-signal IC development. Sub-circuits which are not embedded in a single System-on-Chip (SOC), such as RF Power amplifiers (PAs), are of particular concern as they are more susceptible to the various ESD events.
This thesis presents the development of integrated ESD protection circuitry for two RFIC Power Amplifier designs. A prototype PA for 2.4 GHz Wireless Local Area Network (WLAN) applications was redesigned to provide protection to the RF input and the PA Control pins. A relatively new technique known as the L-C tank approach was used to protect the RFinput while a standard diode ring approach was used to protect the control line. The protection techniques studied were subsequently extended to a completely protected three-stage PA targeting 1.9 GHz Digitally Enhanced Cordless Telephone (DECT) applications. An on-chip shunt-L-series-C input matching network was used to provide ESD protection to the input pin of the DECT PA. A much more area efficient (as compared to the diode ring technique) Zener diode approach was used to protect the control and signal lines. The PA's RF performance was virtually unaffected by the addition of the protection circuits.
Both PAs were designed in a commercially available 0.5 ìm SiGe-HBT process. The partially protected WLAN PA was fabricated and packaged in a 3mm x 3mm Fine Pitch Quad Flat Package FQFP-N 12 Lead package and had a measured ESD protection rating of ± 1kV standard Human Body Model (HBM) ESD test. The simulated DECT PA demonstrated +1.5kV/-4kV HBM performance.Master of Science
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Černá, Martina. "Překážky volného pohybu pracovníků v judikatuře ESD." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-18117.
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The aim of my thesis is to acquaint the reader with the problematic of free movement of workers, both from the theoretical point of view and from practical point of view based on the European Court of Justice cases. In the theoretical part of the thesis, I focus on the characteristics of internal market and definition of free movement of persons and workers. I mention individual law regulations that significantly influence the problematic of free movement of persons. Further, I describe different exceptions from free movement of workers, mutual recognition of academic qualifications and social security regarding the movement of workers. And at last in my practical part, I analyze individual cases of ECJ which have had the most significant impact on the development of free movement of workers.
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Nasdala, Ines. "Funktion der Transmembranproteine ESAM und JAM-A bei Zell-Zell-Interaktionen." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974105538.
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Pichler, Lothar. "Comparison of the French and German approaches to ESDP and NATO." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2004. http://library.nps.navy.mil/uhtbin/hyperion/04Jun%5FPichler.pdf.
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Escudié, Fabien. "Optimisation de modèles comportementaux de composants pour la prédiction de défaillances fonctionnelles et matérielles liées aux décharges électrostatiques (ESD)." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30266/document.
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Les événements transitoires de forte puissance (EFT - Electrical Fast Transient) sont l'une des préoccupations des concepteurs de systèmes embarqués. Ils peuvent conduire au dysfonctionnement du système et sont à l'origine d'un grand nombre de défaillances matérielles et fonctionnelles. Notre étude est principalement portée sur l'impact des décharges électrostatique (ESD - Electro Static Discharge) sur l'électronique embarquée dans un véhicule. D'après une étude de Renault, un véhicule peut subir deux décharges par jour durant sa vie. Les ingénieurs systèmes ne disposent pas de moyen pour prédire l'impact de ces décharges dans les systèmes, et les solutions actuelles sont essentiellement basées sur l'expérience. Afin de prédire le chemin d'un ESD dans tout le système électronique et la stratégie de protection à adopter pour protéger les composants les plus sensibles, des recherches dans le monde entier sont en cours. Les travaux de recherche du groupe ESE du LAAS-CNRS ont mené à des méthodologies de modélisation de composant passif, de circuit intégré et de carte électronique en VHDL-AMS. Les circuits intégrés sont dotés d'un réseau de protection ESD interne qui permet de détourner le stress des zones critiques. La méthodologie développée au cours des précédentes années permet de modéliser le comportement de ce réseau de protection. Cependant, ces modèles sont rudimentaires, ils décrivent uniquement le niveau de déclenchement de la protection et son impédance quasi-statique en fonction du niveau de stress ESD. Aucune information sur le comportement transitoire de la protection n'est décrite dans le modèle. Il est donc difficile de prévoir certaines défaillances liées aux phénomènes transitoires de déclenchement des protections faisant apparaitre de très fortes surtensions ou des niveaux de courant mal évalués. Les différents aspects abordés durant cette thèse permettent de résoudre ces problèmes en proposant des modèles dynamiques, et différentes méthodes pour pouvoir extraire les paramètres des modèles.[...]Electrical Fast Transient (EFT) are one of the concerns of embedded system engineers. They can lead to system malfunction. EFT are the cause of a large number of hardware and software failures. Our study is mainly focused on the impact of Electro Static Discharge (ESD) on embedded electronic systems, focusing on car's applications. According to a Renault's study, a car can suffer two discharges per day during its entire life. System engineers do not have any tools to predict the ESD impact on the systems. In order to predict the ESD path throughout the electronic system and adjust the ESD protection strategy to provide proper protection for all critical components, some researches around the world are in process. The research results from ESE working group from the LAAS-CNRS laboratory, were mainly on passive components, integrated circuits and electronics boards modeling methods, implemented in VHDL-AMS language. Integrated circuits have an internal ESD protection network that helps to deflect the stress from critical areas. The methodology developed in the last few years allows to model the behavior of this protection network. However, these models are basically made, they are made of the triggering level of the protection and the impedance value of the component depending on the ESD stress amplitude. No information on the transient behavior of the protections is included in this model. It is not possible to predict some failures related to the transient phenomenon of the protection like triggering and turning on time that induce very high overvoltage or mismatch on the current levels estimation. The various topics covered during this thesis allows to solve these problems by using a, proposed dynamic model. Different methods are proposed to extract the parameters used into the dynamic model. One important point also aborted into this document is that the model have to be able to predict the soft failure which can appear in the system during an ESD stress.[...]
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Cao, Yiqun [Verfasser], Stephan [Akademischer Betreuer] Frei, and Bernd [Gutachter] Deutschmann. "High-voltage ESD structures and ESD protection concepts in smart power technologies / Yiqun Cao ; Gutachter: Bernd Deutschmann ; Betreuer: Stephan Frei." Dortmund : Universitätsbibliothek Dortmund, 2019. http://d-nb.info/1200209605/34.
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Narasimha, Raju Divya. "Study of ESD effects on RF power amplifiers." Master's thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4993.
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Today, ESD is a major consideration in the design and manufacture of ICs. ESD problems are increasing in the electronics industry because of the increasing trend toward higher speed and smaller device sizes. There is growing interest in knowing the effects of ESD protection circuit on the performance of semiconductor integrated circuits (ICs) because of the impact it has on core RF circuit performance. This study investigated the impact of ESD protection circuit on RF Power amplifiers. Even though ESD protection for digital circuits has been known for a while, RF-ESD is a challenge. From a thorough literature search on prior art ESD protection circuits, Silicon controlled rectifier was found to be most effective and reliable ESD protection for power amplifier circuit. A SCR based ESD protection was used to protect the power amplifier and a model was developed to gain better understanding of ESD protected power amplifiers. Simulated results were compared and contrasted against theoretically derived equations. A 5.2GHz fully ESD protected Class AB power amplifier was designed and simulated using TSMC 0.18 micrometer] technology. Further, the ESD protection circuit was added to a cascoded Class-E power amplifier operating at 5.2 GHz. ADS simulation results were used to analyze the PA's RF performance degradation. Various optimization techniques were used to improve the RF circuit performance.ID: 029809372; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Thesis (M.S.)--University of Central Florida, 2011.; Includes bibliographical references.
M.S.
Masters
Electrical Engineering and Computer Science
Engineering and Computer Science
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Malobabic, Slavica. "Transient Safe Operating Area (TSOA) for ESD applications." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5420.
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A methodology to obtain design guidelines for gate oxide input pin protection and high voltage output pin protection in Electrostatic Discharge (ESD) time frame is developed through measurements and Technology Computer Aided Design (TCAD). A set of parameters based on transient measurements are used to define Transient Safe Operating Area (TSOA). The parameters are then used to assess effectiveness of protection devices for output and input pins. The methodology for input pins includes establishing ESD design targets under Charged Device Model (CDM) type stress in low voltage MOS inputs. The methodology for output pins includes defining ESD design targets under Human Metal Model (HMM) type stress in high voltage Laterally Diffused MOS (LDMOS) outputs. First, the assessment of standalone LDMOS robustness is performed, followed by establishment of protection design guidelines. Secondly, standalone clamp HMM robustness is evaluated and a prediction methodology for HMM type stress is developed based on standardized testing. Finally, LDMOS and protection clamp parallel protection conditions are identified.ID: 031001296; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Adviser: Juin J. Liou.; Title from PDF title page (viewed March 7, 2013).; Thesis (Ph.D.)--University of Central Florida, 2012.; Includes bibliographical references (p. 252-262).
Ph.D.
Doctorate
Electrical Engineering and Computer Science
Engineering and Computer Science
Electrical Engineering
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Pettersson, G�ran Sven Erik. "An illustrated overview of ESM and ECM systems." Thesis, Monterey, California. Naval Postgraduate School, 1993. http://hdl.handle.net/10945/26584.
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This thesis gives an overview of electronic support measures (ESM) and electronic countermeasures (ECM) systems. The objective is to give the intended reader, students of the EW curriculum new to the subject, an introduction to several different electronic warfare systems. The thesis consists of seven chapters discussing different areas of EW. The first two chapters introduce the reader to the definitions of EW and the threat which EW equipment is designed to counter, The following two chapters are a presentation of typical ESM and ECM systems. The final three chapters cover the integration of ESM and ECM systems as well as two subjects, suppression of enemy air defense and directed energy weapons, which differ from the typical ECM systems. Included with each chapter describing systems is a conclusion section which discusses possible future developments for the group of systems
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Běťák, Petr. "Modelování a návrh ESD ochran v integrovaných obvodech." Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-233447.
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The thesis introduces new semiconductor structures that are used as protections against Electrostatic Discharge occuring in integrated circuits. The fundamental structure for modeling and simulation has been lateral Silicon Controlled Rectifier. This SCR structure has been modificated to enable tuning of the triggering and holding voltages by changing geometrical mask dimensions. On the base of modeling and simulation the new proposed structures have been published. Also several protection structures have been designed to be manufactured and measured on a testchip. The final electrical behavior has been verified by measurement. Finally, the focus has been aided to protection circuit with bipolar transistor. This approach has been also simulated and verified by measurement. Advantages and disadvantages of the proposed protection structures are commented in the thesis.
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Papoušek, Tomáš. "Omezení volného pohybu pracovníků v rámci rozhodnutí ESD." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-2476.
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Cílem této práce je rozebrání základních principů fungování volného pohybu pracovníků se zaměřením na jeho jednotlivá omezení, a to ve vztahu k judikatuře Evropského soudního dvora. V práci jsou tak popsána jak přípustná tak zakázáná omezení.
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Nolhier, Nicolas. "Methodologie de conception des protections des circuits intégrés contre les décharges électostatiques." Habilitation à diriger des recherches, Université Paul Sabatier - Toulouse III, 2005. http://tel.archives-ouvertes.fr/tel-00265344.
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La problématique des agressions par décharges électrostatiques (ESD) est un facteur critique dans la fiabilité des circuits intégrés. Ce document effectue la synthèse des travaux menés au LAAS-CNRS dans ce domaine. Les points suivants seront plus particulièrement abordés : - L'étude des mécanismes physiques qui gèrent le comportement d'un composant lors d'une décharge ESD - La mise en place d'une méthodologie de conception de structures de protection - Son application au développement de solutions de protection innovantes La dernière partie de ce document propose les perspectives de cet axe de recherche qui sont principalement motivés par les progrès technologiques des circuits intégrés, l'évolution des normes de robustesse et l'extension de nos travaux au niveau du système.
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Guthrie, S. E. "Exploration of the use of ESEM for the study of biological materials." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599800.
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This study investigates the potential of environmental scanning electron microscopy (ESEM) for use in the biological sciences. The morphology observed in fixed, dried and coated specimens imaged in the SEM is compared with that observed in fixed and untreated samples in the ESEM, looking at human monocyte-derived macrophages (MDMs). Artefacts are observed as a result of sample preparation for SEM including volume loss and cracking. Samples viewed in the ESEM appear broadly similar and fixation is found to offer some protection against beam damage for delicate samples. Cell viability in ESEM is explored in 3T3 fibroblasts and human MDMs. It is found that while samples survive cooling and pumpdown, cells cannot be imaged live. This is due to damage sustained when the cells are exposed to evaporating conditions in order to remove surface liquid and uncover the cells for imaging. With the fibroblasts, a distinctive morphology is seen which suggests this process is via membrane collapse. E. coli, however, are found to be viable after imaging in ESEM under carefully controlled environmental conditions. Bacteria have a cell wall whilst mammalian cells only have a single membrane. This suggests that resistance to osmotic shock is key to viability of biological samples in ESEM and that environmental conditions are more significant than beam damage for such samples. Wet scanning transmission electron microscopy (STEM) is also investigated as a tool for biology, and the best imaging conditions for biological samples are established. Images are presented showing that a range of features can be imaged using this technique in mammalian cells and bacteria, revealing internal structure.
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Craven, J. P. "Secondary electron imaging of liquid droplets on insulating surfaces in the ESEM." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598132.
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The Environmental Scanning Electron Microscope (ESEM) has rapidly become established as a new generation of scanning electron microscopes. The sustainability and utilisation of a gaseous atmosphere in these microscopes has opened the way for new electron microscopy studies of insulating, biological and even fully hydrated systems. Recently there has been an increasing drive to push the limits of the technique further to perform more in situ dynamic experiments and extract more quantitative information. However before this potential can be realised, some fundamental groundwork must be done. In this thesis we focus on the interpretation of secondary electron contrast obtained from liquid water droplets, with the aim to make a quantitative interpretation of contact angle. We develop and present two experimental methodologies to explore this parameter: 1) by direct imaging of water droplet profiles on flat insulating substrates and, ii) indirectly by quantitative interpretation of contrast profiles obtained across the surface of water droplets. In developing a procedure to measuring contact angle directly in the ESEM we focus on the practical implications of depositing and stabilising regular droplets and correctly mounting the substrates. We also compare the ESEM contact angle measurements to macroscopic optical measurements performed on the same surfaces to ensure the accuracy of the results. In extracting contact angle from contrast profiles we develop a general model of SE topographic contrast for the ESEM, considering the relative dominance of the different signal contributions that form the final image and how they are processes into an image. We relate the contrast profiles to the geometric shape of the water droplets and find a correlation between the breakdown of the model and the size of the interaction volume of the primary electron beam.
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Joy, Ryan Mears. "Dcbld2/esdn Is Essential For Proper Optic Tract Formation And Retinal Lamination." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/563.
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ABSTRACT
The Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2/ESDN/CLCP1) is a type-I, transmembrane receptor that mediates diverse cellular processes such as angiogenesis, vascular remodeling, cellular migration and proliferation. Identification of DCBLD2 in a proteomics screen to identify substrates of Src family tyrosine kinases that bind the Src homology 2 domain of CT10 regulator of kinase-Like (CrkL), a critical scaffolding protein for neuronal development, led to a need for further characterization of the protein. To elucidate the role of this interaction and potential novel function of DCBLD2, an in vivo approach utilizing Danio rerio (zebrafish) was conducted. dcbld2 was found localized in neuronal tissues during development, with strong expression in the retina. Knockdown of the protein led to a deficiency of retinal ganglion cells and the optic tracts, or nerve bundles, they project to innervate the brain. Serial sections revealed malformation of the normally discrete layering of retinal cell types, and smaller eye area overall.
These findings suggest a role for dcbld2 in developing nervous tissue, specifically neuronal migration during interkinetic nuclear migration. While it is has been shown that dcbld2 has a role in the developmental patterning of intersegmental vessels in the tail of zebrafish, the protein has not been investigated in the context of neurogenesis. The loss of RGCs and lamination defects observed in the eye, along with its association with the CrkL-SH2 domain, implicate it in processes that allow for the proper differentiation of neurons. This study has brought us further down the path to understanding the multiple functions of the receptor; however, further studies are required to delineate the exact mechanistic function of the dcbld2 receptor.
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Larivé, Maxime H. A. "From Promoting Security to Enforcing It: The Integration of the European Security Strategy during the Solana Era." Scholarly Repository, 2012. http://scholarlyrepository.miami.edu/oa_dissertations/713.
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This dissertation seeks to assess the degree of integration in the sector of security and defense of the European Union. The emphasis is brought on the Solana era, 1999-2009, as Mr. Solana was the first High Representative for the Common Foreign and Security Policy of the EU. His mandate was axiomatic in shaping a common security strategy for the Union. In order to measure the degree of integration, this dissertation applied an eclectic theoretical approach on three case studies looking at three distinct levels of analysis: domestic, homeland counterterrorism; regional, energy security vis-à-vis Russia; international, EUPOL Afghanistan mission.
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Telford, Christine. "A review of ESM mood disorder research and a study of ESM faciliitated self-and other awareness in adults with asperger syndrome." Thesis, University of Sheffield, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500140.
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Bönisch, Sven Peter. "Die elektrostatische Entladung (ESD) bei kleinen Abständen und Spannungen." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=969940599.
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Zur, Nieden Friedrich [Verfasser]. "Charakterisierung und Modellierung von ESD-Prüfgeneratoren / Friedrich Zur Nieden." München : Verlag Dr. Hut, 2014. http://d-nb.info/1063221897/34.
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