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Journal articles on the topic 'Esmolol Hydrochloride'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Bhavadip, Tanna* Dhirendra Kumar Tarai Khyati Bhupta Dr. Santosh R. Kirtane. "Development And Validation of RP-HPLC Method for Estimation of Esmolol HCL from Semisolid Dosage Form." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2741–64. https://doi.org/10.5281/zenodo.15442329.

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Esmolol Hydrochloride belongs to the class II anti-arrhythmic drugs. Topical Esmolol Hydrochloride used as a Novel Treatment Modality for Diabetic Foot Ulcers. Development and validation of Simple, Precise and Accurate RP-HPLC method for estimation of Esmolol Hydrochloride in Semi solid dosage form. The validation of this method was achieved as per ICH Q2 (R2) guidelines with the optimized experimental conditions. To achieve the proposed method on Intsil C18 column (300 mm x 3.9 mm, 5 µm) column as Stationary Phase and run time was 20 min. The Mobile Phase consists of Acetonitrile:6.8g/L

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Eswari Prasanna P, Katika Surya Gowthami, Asha Latha A, and Rajendra Prasad M. "Attenuation of cardiovascular responses to laryngoscopy and intubation –A comparative study between IV esmolol hydrochloride and lignocaine hydrochloride." Asian Journal of Medical Sciences 13, no. 6 (2022): 42–50. http://dx.doi.org/10.3126/ajms.v13i6.42898.

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Background: Laryngoscopy and tracheal intubation are frequently associated with sympathetic stress response. Lignocaine and esmolol are useful to decrease the sympathetic response to laryngoscopy and intubation. Aims and Objectives: The aim of the study was to study the effectiveness of lignocaine and esmolol administered intravenously before laryngoscopy and intubation in attenuating the sympathetic response. Materials and Methods: The prospective, randomized, and controlled study was conducted in Maharajah’s Institute of Medical Sciences Hospital for a period of 18 months from January 2016 t

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Rastogi, Ashu, Sudhir A. Kulkarni, Sanjay Agarwal, et al. "Topical Esmolol Hydrochloride as a Novel Treatment Modality for Diabetic Foot Ulcers." JAMA Network Open 6, no. 5 (2023): e2311509. http://dx.doi.org/10.1001/jamanetworkopen.2023.11509.

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ImportancePreclinical and phase 1/2 studies with esmolol hydrochloride suggest its potential role in treatment of diabetic foot ulcers (DFUs).ObjectiveTo study the efficacy of topical esmolol for healing of uninfected DFUs.Design, Setting, and ParticipantsA randomized, double-blind, multicenter, phase 3 clinical trial was conducted from December 26, 2018, to August 19, 2020, at 27 referral centers across India. Participants included adults with DFUs.InterventionsParticipants were randomized after a run-in phase (1 week) to receive esmolol, 14%, gel with standard of care (SoC), SoC only, or veh

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Somasekhar, Vanita, and D. Gowri Sankar. "Development and Validation of a Rapid RP-HPLC Method for the Estimation of Esmolol Hydrochloride in Bulk and Pharmaceutical Dosage Forms." E-Journal of Chemistry 7, no. 3 (2010): 807–12. http://dx.doi.org/10.1155/2010/470785.

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A reverse phase HPLC method is described for the determination of esmolol hydrochloride in bulk and injections. Chromatography was carried on a C18column using a mixture of acetonitrile, 0.05 M sodium acetate buffer and glacial acetic acid (35:65:3 v/v/v) as the mobile phase at a flow rate of 1 mL/min with detection at 275 nm. The retention time of the drug was 4.76 min. The detector response was linear in the concentration of 1-50 μg/mL. The limit of detection and limit of quantification was 0.614 and 1.86 μg/mL respectively. The method was validated by determining its sensitivity, linearity,

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5

Baaske, D. Michael, Steven D. Dykstra, Dietmar M. Wagenknecht, and Nancy N. Karnatz. "Stability of esmolol hydrochloride in intravenous solutions." American Journal of Health-System Pharmacy 51, no. 21 (1994): 2693–96. http://dx.doi.org/10.1093/ajhp/51.21.2693.

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Wiest, Donald B., Sandra S. Garner, and Leah M. Childress. "Stability of esmolol hydrochloride in 5% dextrose injection." American Journal of Health-System Pharmacy 52, no. 7 (1995): 716–18. http://dx.doi.org/10.1093/ajhp/52.7.716.

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Muller, Matthew D., Tariq Ali Ahmad, Alvaro F. Vargas Pelaez, et al. "Esmolol infusion versus propranolol infusion: effects on heart rate and blood pressure in healthy volunteers." Journal of Applied Physiology 122, no. 3 (2017): 511–19. http://dx.doi.org/10.1152/japplphysiol.00940.2016.

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Despite its widespread clinical use, the β1-adrenergic receptor antagonist esmolol hydrochloride is not commonly used in human physiology research, and the effective dose of esmolol (compared with the nonselective β-blocker propranolol) is unclear. In four separate studies we used cycle ergometry exercise and infusions of isoproterenol and epinephrine to test the heart rate (HR)-lowering effect of esmolol compared with propranolol and saline in healthy humans. In cohort 1, both esmolol (ΔHR 57 ± 6 beats/min) and propranolol (ΔHR 56 ± 7 beats/min) attenuated exercise tachycardia compared with s

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8

Sun, Lixiao, and Jie Su. "Application Evaluation of Esmolol Hydrochloride-Assisted Interventional Therapy on New-Onset Atrial Fibrillation in Patients with Severe Sepsis: A Retrospective Study." Heart Surgery Forum 27, no. 3 (2024): E282—E288. http://dx.doi.org/10.59958/hsf.7273.

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Objective: This study aims to explore the application effect of adjuvant therapy with esmolol hydrochloride on new-onset atrial fibrillation (NOAF) in patients with severe sepsis. Methods: Retrospective analysis was conducted on 170 patients with NOAF and severe sepsis admitted to our hospital from January 2022 to January 2023. After excluding eight patients who did not meet the inclusion criteria, the remaining 162 patients were included in the study. Based on different treatment methods, the patients were divided into the control group (n = 83, routine treatment) and the observation group (n

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Angaran, David M., Nathan J. Schultz та Victor H. Tschida. "Esmolol hydrochloride: An ultrashort-acting, β-adrenergic blocking agent". American Journal of Health-System Pharmacy 43, № 5 (1986): 1322–41. http://dx.doi.org/10.1093/ajhp/43.5.1322.

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10

Karnatz, Nancy N., Joanne Wong, David M. Baaske, John H. Johnson, Earl R. Speicher, and Dale E. Herbranson. "Stability of esmolol hydrochloride and sodium nitroprusside in intravenous admixtures." American Journal of Health-System Pharmacy 46, no. 1 (1989): 101–4. http://dx.doi.org/10.1093/ajhp/46.1.101.

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11

Das, Gopal, and Janine C. Ferris. "Generalized Convulsions in a Patient Receiving Ultrashort-Acting Beta-Blocker Infusion." Drug Intelligence & Clinical Pharmacy 22, no. 6 (1988): 484–85. http://dx.doi.org/10.1177/106002808802200608.

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Beta-receptor blocking agents are commonly used to treat patients with heart disease, and generalized seizures due to therapy with these agents are rare. All reported cases of seizures due to beta blocking agents have occurred only in those subjects who ingested large doses of the drugs. We observed generalized convulsions in a patient who was receiving therapeutic doses of an ultrashort-acting beta-blocking agent (esmolol hydrochloride) intravenously. A literature survey and possible mechanisms by which these agents induce seizures are presented.

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12

Schaaf, Larry J., Dennis H. Robinson, Gregory J. Vogel, Bradley G. Wulf, Kristin D. Drda, and John O. Moses. "Stability of esmolol hydrochloride in the presence of aminophylline, bretylium tosylate, heparin sodium, and procainamide hydrochloride." American Journal of Health-System Pharmacy 47, no. 7 (1990): 1567–71. http://dx.doi.org/10.1093/ajhp/47.7.1567.

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13

Zhao, Bin, and Wenyan Sun. "Incompatibility of esmolol hydrochloride and furosemide in a central venous access port." American Journal of Health-System Pharmacy 71, no. 11 (2014): 901–2. http://dx.doi.org/10.2146/ajhp130526.

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14

Cheeran, Susan T. "Attenuation of Haemodynamic Stress Response to Laryngoscopy and Intubation with two Doses of Esmolol Hydrochloride." Journal of Medical Science And clinical Research 05, no. 05 (2017): 22157–75. http://dx.doi.org/10.18535/jmscr/v5i5.144.

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15

Ayuso, Angeles, Mercedes Luis, Xavier Sala, Jesús Sánchez, and José Traserra. "Effects of Anesthetic Technique on the Hemodynamic Response to Microlaryngeal Surgery." Annals of Otology, Rhinology & Laryngology 106, no. 10 (1997): 863–68. http://dx.doi.org/10.1177/000348949710601010.

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Our aim was to study the attenuation of the hemodynamic response to microlaryngeal surgery by β-blocking agents used as support drugs to the anesthetic technique. The study was carried out in 30 patients randomly allocated to one of three groups. The control group received only anesthetic drugs. The second group received labetalol hydrochloride 0.3 mg/kg 3 minutes before induction and 0.15 mg/kg 2 minutes prior to the start of suspension of the larynx. The third group received esmolol hydrochloride 500 μg/kg 3 minutes prior to induction and a continuous infusion of 300 μg/kg during the surgica

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16

El-Tohamy, Maha F., and Nawal A. Alarfaj. "Electrochemical System for Determination of Esmolol Hydrochloride Using Square Wave Adsorptive Stripping Voltammetry." International Journal of Electrochemical Science 11, no. 4 (2016): 2709–20. http://dx.doi.org/10.1016/s1452-3981(23)16134-7.

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17

Soumya, Singh, Kumar Singh Amit, and Shanker Singh Uma. "A Hospital Based Analytical Assessment of the Efficacy of Intravenous Esmolol and Intravenous Magnesium Sulphate in Attenuating Haemodynamic Response to Laryngoscopy and Endotracheal Intubation." International Journal of Pharmaceutical and Clinical Research 14, no. 12 (2022): 1248–54. https://doi.org/10.5281/zenodo.13239782.

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<strong>Aim:</strong> To compare the effects of intravenous administration of esmolol and magnesium sulfate on the hemodynamic changes due to LETI. <strong>Methodology:</strong> This study was a prospective study done on 50 patients in Department of Anesthesiology, AIIMS, Patna, Bihar for six months. Sixty patients posted for elective surgeries were randomly selected and were divided in two groups of thirty each i.e. Group E and group M. Patients were thoroughly evaluated pre-operatively, kept NPO from previous midnight, and were administered Alprazolam 0.5mg orally. Group E pat

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18

Colucci, Robert D., Louis E. Cobuzzi, and Neil A. Halpern. "Visual Compatibility of Esmolol Hydrochloride and Various Injectable Drugs During Simulated Y-Site Injection." American Journal of Health-System Pharmacy 45, no. 3 (1988): 630–32. http://dx.doi.org/10.1093/ajhp/45.3.630.

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19

VUCEVIC, M., G. M. PURDY, and F. R. ELLIS. "ESMOLOL HYDROCHLORIDE FOR MANAGEMENT OF THE CARDIOVASCULAR STRESS RESPONSES TO LARYNGOSCOPY AND TRACHEAL INTUBATION." British Journal of Anaesthesia 68, no. 5 (1992): 529–30. http://dx.doi.org/10.1093/bja/68.5.529.

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20

Dave, Vivek, Swapnil Sharma, and Sarvesh Paliwal. "Design and evaluation of esmolol hydrochloride ocular inserts with special reference to glaucoma treatment." Journal of Pharmaceutical Investigation 43, no. 2 (2013): 89–99. http://dx.doi.org/10.1007/s40005-013-0056-5.

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21

Brinda, Jodhani* Dhirendra Kumar Tarai Khyati Bhupta Dr. Santosh Kirtane. "Development And Validation of RP-HPLC Method for Simultaneous Estimation of Dapagliflozin Propanediol Monohydrate and Telmisartan in Synthetic Mixture." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 1319–37. https://doi.org/10.5281/zenodo.15611286.

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Dapagliflozin and Telmisartan belongs to the anti-diabetic drugs. Development and validation of Simple, Precise and Accurate RP-HPLC method for estimation of Dapagliflozin and Telmisartan in solid dosage form. The validation of this method was achieved as per ICH Q2 (R2) guidelines with the optimized experimental conditions. To achieve the proposed method on Intsil C18 column (250 mm x 4.6 mm, 5 µm) column as Stationary Phase and run time was 10 min. The Mobile Phase consists of Acetonitrile: Methanol (75:25v/v). UV detection was carried out at 272nm. Linearity co-relation co-efficient f

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22

Prakash, Jay, Shailesh Kumar, Girishkumar Sodar, Neha Sadhoo, Brijesh GC, and Natesh S Rao. "Attenuation of Cardiovascular Responses to Laryngoscopy and Intubation: A Comparative Study between I.V. Esmolol Hydrochloride and Fentanyl Citrate." Indian Journal of Anesthesia and Analgesia 6, no. 3 (2019): 713–20. http://dx.doi.org/10.21088/ijaa.2349.8471.6319.3.

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23

Jordan, Desmond, Steven M. Shulman, and Edward D. Miller. "Esmolol Hydrochloride, Sodium Nitroprusside, and Isoflurane Differ in Their Ability to Alter Peripheral Sympathetic Responses." Anesthesia & Analgesia 77, no. 2 (1993): 281–90. http://dx.doi.org/10.1213/00000539-199308000-00012.

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Jordan, Desmond, Steven M. Shulman, and Edward D. Miller. "Esmolol Hydrochloride, Sodium Nitroprusside, and Isoflurane Differ in Their Ability to Alter Peripheral Sympathetic Responses." Anesthesia & Analgesia 77, no. 2 (1993): 281–90. http://dx.doi.org/10.1213/00000539-199377020-00012.

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25

Thompson, Dennis F., and G. Dail Thompson. "Visual compatibility of esmolol hydrochloride and furosemide in 5% dextrose or 0.9% sodium chloride injections." American Journal of Health-System Pharmacy 44, no. 12 (1987): 2740. http://dx.doi.org/10.1093/ajhp/44.12.2740.

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26

Karnatz, Nancy N., Joanne Wong, Helen Kesler, David M. Baaske, and Earl R. Speicher. "Compatibility of esmolol hydrochloride with morphine sulfate and fentanyl citrate during simulated Y-site administration." American Journal of Health-System Pharmacy 45, no. 2 (1988): 368–71. http://dx.doi.org/10.1093/ajhp/45.2.368.

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Jordan, D. A., S. M. Shulman, and E. D. Miller. "ESMOLOL HYDROCHLORIDE, SODIUM NITROPRUSSIDE, AND ISOFLURANE DIFFER IN THEIR ABILITY TO ALTER PERIPHERAL SYMPATHETIC RESPONSES." Anesthesiology 71, Supplement (1989): A497. http://dx.doi.org/10.1097/00000542-198909001-00497.

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28

T, Padma, and Mydhili K. "ATTENUATION OF HAEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION: ROLE OF I.V. BOLUS DOSE OF ESMOLOL HYDROCHLORIDE AND LIGNOCAINE HYDROCHLORIDE : A COMPARATIVE STUDY." Journal of Evidence Based Medicine and Healthcare 2, no. 39 (2015): 6274–80. http://dx.doi.org/10.18410/jebmh/2015/864.

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29

Karnatz, Nancy N., David M. Baaske, Dale E. Herbranson, and Mark S. Eliason. "High-performance liquid chromatographic method for the determination of esmolol hydrochloride in solutions and parenteral formulations." Journal of Chromatography A 330 (January 1985): 420–24. http://dx.doi.org/10.1016/s0021-9673(01)82008-2.

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30

Denysenko, A. I., and V. I. Cherniy. "PERIOPERATIVE METABOLISM IN PATIENTS WITH THYROTOXICOSIS, POSSIBILITIES OF ITS CORRECTION." Клінічна та профілактична медицина 3, no. 17 (2021): 36–48. http://dx.doi.org/10.31612/2616-4868.3(17).2021.05.

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In the past, thyroid surgery has been the most common cause of thyroid storm, but recently, preoperative drugs that create a euthyroid state before surgery have somewhat improved treatment outcomes. Therefore, the anesthesia of such operations is very important. The aim of this work: to evaluate the possibility of using dexmedetomidine for perioperative correction of metabolism in thyroidectomy under general anesthesia in patients with thyrotoxicosis. Materials and methods. The study was prospective, not randomized. The study involved 137 patients (53 men, 84 women, aged 21 to 76 y

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31

Karunanithi, Sathya Narayanan, Geeta Bhandari, Kedar Singh Shahi, Aditya Kumar Chauhan, and Pooja Gautam. "Comparative Study of IV Esmolol, IV Diltiazem, and IV Lignocaine Hydrochloride in Attenuating Pressure Response to Laryngoscopy and Intubation." Journal of Evolution of Medical and Dental Sciences 9, no. 29 (2020): 2053–57. http://dx.doi.org/10.14260/jemds/2020/447.

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32

Yadav, Satyendra, and R. S Verma. "Attenuation of haemodynamic responses of laryngoscopy and endotracheal intubation: An evaluation of efficacy of single intravenous dose of esmolol hydrochloride." Indian Journal of Clinical Anaesthesia 6, no. 1 (2019): 40–46. http://dx.doi.org/10.18231/2394-4994.2019.0009.

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33

Tamaskar, Dr Aparna, Dr Sumit Bhargava, Dr Madhumita Rao, Dr Sudip Bhargava, and Dr Manorama Singh. "Effect of Esmolol hydrochloride on attenuation of stress response during laryngoscopy and intubation in ear, nose and throat (ENT) procedures." International Journal of Medical Research and Review 3, no. 11 (2015): 1370–77. http://dx.doi.org/10.17511/ijmrr.2015.i11.248.

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34

Hussein, Wiam I., and Mohammed Hassanein. "58th EASD Annual Meeting from 19 to 23 September 2022, Stockholm, Sweden (Virtual)." Journal of Diabetes and Endocrine Practice 05, no. 03 (2022): 126–31. http://dx.doi.org/10.1055/s-0042-1759707.

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AbstractThe 58th European Association for the Study of Diabetes (EASD) Annual Meeting was held between 19 and 23 September 2022 in Stockholm, Sweden. It was also fully streamlined online. The authors attended the conference, giving a narrative commentary on what they felt were the highlights of the meeting. Several interesting lectures were presented. The ADA-EASD hyperglycemia management consensus was among the landmark presentations. The development of a particular model that could predict severe hypoglycemia risk in people with type 2 diabetes (T2D) was interesting. The remission of T2D dat

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35

Bhaskar, B. Vijaya, and Sarab Jagadeesa Charlu. "Comparative Study of Haemodynamic Responses to Laryngoscopy and Oral Endotracheal Intubation in Healthy Normotensive Adults with Prior Administration of Lignocaine and Esmolol Hydrochloride." Journal of Evolution of Medical and Dental Sciences 9, no. 13 (2020): 1069–72. http://dx.doi.org/10.14260/jemds/2020/230.

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36

Tengler, Jan, Iva Kapustíková, Ondřej Stropnický, et al. "Synthesis of new (arylcarbonyloxy)aminopropanol derivatives and the determination of their physico-chemical properties." Open Chemistry 11, no. 11 (2013): 1757–67. http://dx.doi.org/10.2478/s11532-013-0302-8.

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AbstractEight hydrochlorides of 3-{2-[(2/4-fluorophenoxy)-ethylamino]}-2-hydroxypropyl-4-alkoxybenzoates and four hydrochlorides of 3-tert-butylamino-2-hydroxypropyl-4-butoxybenzoates were prepared as potential antagonists of the β1-adrenergic receptor (beta-blockers). A multistep synthesis of these compounds is described as well as their detailed analytical characterization. The pharmacokinetic properties of these weak base compounds are significantly influenced by their acid-base dissociation constant, pK a. The knowledge of this value is crucial for new drug development. This paper is aimed

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37

Kulkarni, Sudhir A., Supreet K. Deshpande, and Ashu Rastogi. "Novel topical esmolol hydrochloride improves wound healing in diabetes by inhibiting aldose reductase, generation of advanced glycation end products, and facilitating the migration of fibroblasts." Frontiers in Endocrinology 13 (August 23, 2022). http://dx.doi.org/10.3389/fendo.2022.926129.

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Aims/ObjectivesWound healing in people with diabetes is delayed secondary to impaired nitric oxide generation, advanced glycation end products (AGE), and poor migration of epithelial cells. We developed a novel topical esmolol hydrochloride (Galnobax) and assessed its efficacy for wound healing in streptozocin-induced diabetic hairless rat.MethodsAll experiments were performed at an animal laboratory and tertiary-care research facility. Ex vivo aldose reductase inhibition was assessed from enzymes obtained from a bacterial culture (spectrophotometer), sorbitol content in homogenized red blood

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38

Mahesh, M., and Arra Sowmya Sri. "Attenuation of Cardiovascular Responses to Laryngoscopy and Intubation-A Comparative Study between IV Esmolol hydrochloride and Lignocaine Hydrochloride." Annals of International medical and Dental Research 2, no. 6 (2016). http://dx.doi.org/10.21276/aimdr.2016.2.6.an8.

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39

Raley, Daniel, Ryan Thornton, and Sara Conway. "Topical esmolol hydrochloride as a novel treatment option for diabetic foot ulcers." Evidence-Based Practice, November 15, 2024. http://dx.doi.org/10.1097/ebp.0000000000002312.

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A. Alarfaj, Nawal. "Electrochemical System for Determination of Esmolol Hydrochloride Using Square Wave Adsorptive Stripping Voltammetry." International Journal of Electrochemical Science, April 2016, 2709–20. http://dx.doi.org/10.20964/110402709.

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Davies, Simon, Zhongping Jian, Feras Hatib, Amy Gomes, and Monty Mythen. "Indicators of haemodynamic instability and left ventricular function in a porcine model of esmolol induced negative inotropy." Journal of Clinical Monitoring and Computing, November 6, 2022. http://dx.doi.org/10.1007/s10877-022-00937-8.

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AbstractTo investigate if the Hypotension Prediction Index was an early indicator of haemodynamic instability in a negative inotropy porcine model, and to assess the correlation of commonly measured indicators of left ventricular systolic function. Eight anaesthetised pigs were volume resuscitated and then underwent an incremental infusion of esmolol hydrochloride (0-3000 mg/hr), following which it was then reduced in a stepwise manner. Full haemodynamic measurements were taken at each stage and measurements of left ventricular systolic function including left ventricular stroke work index, ej

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42

Wu, Hongchang, Ting Wang, Di Wu, et al. "Insight into the Structure and Formation Mechanism of Esmolol Hydrochloride Polymorphs Based on Experiments and Molecular Simulations." Crystal Growth & Design, December 9, 2024. https://doi.org/10.1021/acs.cgd.4c01015.

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43

Rastogi, Ashu, Raveena Singh, Umanath Adhikari, Sudhir A. Kulkarni, and Supreet K. Deshpande. "Effect of patient and wound characteristics on diabetic foot ulcer healing in phase 3 study of novel topical esmolol hydrochloride." International Journal of Diabetes in Developing Countries, April 15, 2024. http://dx.doi.org/10.1007/s13410-024-01336-2.

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44

Rastogi, Ashu, Sudhir Kulkarni, Supreet Deshpande, et al. "Novel Topical Esmolol Hydrochloride (Galnobax) For Diabetic Foot Wound: Phase 1 /2, Multicentre, Randomized, Double-Blind, Vehicle-Controlled, Parallel-Group Study." Advances in Wound Care, October 16, 2022. http://dx.doi.org/10.1089/wound.2022.0093.

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45

Zhang, Wei, Wen-Bo Li, Qi Wang, et al. "An innovative impurity profiling of Esmolol Hydrochloride Injection using UPLC-MS based multiple mass defect filter and chemometrics with in-silico toxicity prediction." Arabian Journal of Chemistry, January 2023, 104573. http://dx.doi.org/10.1016/j.arabjc.2023.104573.

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46

Oguro, Sota, Hideki Ota, Satoru Yanagaki, et al. "Transvenous Radiofrequency Catheter Ablation for an Aldosterone-Producing Tumor of the Left Adrenal Gland: A First in Human Case Report." CardioVascular and Interventional Radiology, November 16, 2023. http://dx.doi.org/10.1007/s00270-023-03584-x.

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Abstract Purpose To describe a novel technique of transvenous radiofrequency catheter ablation of an aldosterone-producing adenoma (APA) of the left adrenal gland using the GOS System (Japan Lifeline, Tokyo, Japan). Using the GOS system, a flexible radiofrequency tip catheter can be inserted into the adrenal central and tributary veins, the drainers for functional tumors. Materials and methods An APA at the left adrenal gland, which was diagnosed by segmental adrenal venous sampling following administration of 0.25 mg cosyntropin, was ablated using the GOS catheter inserted into adrenal tribut

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47

Jadhav, U., S. Ray, S. Bansal, and T. Nair. "Effectiveness of bisoprolol versus selective beta-1 blockers in the management of hypertension: a systematic review and meta-analysis of randomized cross-over trials." European Heart Journal 42, Supplement_1 (2021). http://dx.doi.org/10.1093/eurheartj/ehab724.2364.

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Abstract Background Cross-over trials carry a higher weightage in choosing a therapeutic agent in clinical practice. A meta-analysis of cross-over trials involving the use of bisoprolol in hypertension (HT) would bring about clarity in positioning this drug. Purpose The present study aimed to clarify the underlying benefits of bisoprolol in the reduction of blood pressure (BP) in HT patients when compared to selective beta-1 blockers (s-BBs - Atenolol, Betaxolol hydrochloride, Esmolol, Acebutolol hydrochloride, Metoprolol succinate, Nebivolol) by performing a meta-analysis of “cross-over” tria

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