Academic literature on the topic 'Estramustine'

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Journal articles on the topic "Estramustine"

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Stearns, M. E., and K. D. Tew. "Estramustine binds MAP-2 to inhibit microtubule assembly in vitro." Journal of Cell Science 89, no. 3 (1988): 331–42. http://dx.doi.org/10.1242/jcs.89.3.331.

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We have investigated the ability of estramustine to bind to rat brain microtubule-associated proteins (MAPs) and purified MAP-2 in vitro. [3H]estramustine's relative affinity for tubulin and MAPs was assessed by gel filtration chromatography, immunoprecipitation and binding assays. Scatchard analysis demonstrated a specific affinity of the drug for MAP-2. Calculations from kinetic parameters and non-linear regression analysis gave a Kd of 15 microM, and a Bmax of 3.4 × 10(−7)M ml-1. Extrapolation of this value suggested that each MAP-2 molecule binds approximately 20 molecules of estramustine.
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&NA;. "Estramustine." Reactions Weekly &NA;, no. 913 (2002): 7. http://dx.doi.org/10.2165/00128415-200209130-00019.

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&NA;. "Estramustine." Reactions Weekly &NA;, no. 773 (1999): 9. http://dx.doi.org/10.2165/00128415-199907730-00022.

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&NA;. "Estramustine phosphate." Drugs & Therapy Perspectives 6, no. 11 (1995): 5–8. http://dx.doi.org/10.2165/00042310-199506110-00002.

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Sangrajrang, Suleeporn, Fabien Calvo, and Arlette Fellous. "Estramustine resistance." General Pharmacology: The Vascular System 33, no. 2 (1999): 107–13. http://dx.doi.org/10.1016/s0306-3623(98)00272-9.

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Fizazi, K., G. R. Hudes, W. R. Berry, et al. "A meta-analysis of individual patient data from randomized trials assessing chemotherapy with and without estramustine in patients with castration-refractory prostate cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 4561. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.4561.

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4561 Background: Estramustine phosphate is a mustard-estradiol conjugate, with evidence of both hormonal and non-hormonal effects. In phase II trials, the response rates of microtubule inhibitors are increased when combined with estramustine. Morbidity includes notably thrombosis in about 7% of cases. Whether combining estramustine with chemotherapy increases survival in castration-refractory prostate cancer (CRPC) is still controversial. Methods: Data from all published and unpublished prospective randomized trials assessing chemotherapy + estramustine versus chemotherapy alone in CRPC were s
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Stearns, M. E., M. Wang, and O. Sousa. "Evidence that estramustine binds MAP-1A to inhibit type IV collagenase secretion." Journal of Cell Science 98, no. 1 (1991): 55–63. http://dx.doi.org/10.1242/jcs.98.1.55.

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Estramustine is a novel anti-microtubule drug shown to bind MAP-1 and MAP-2 (microtubule-associated proteins) in vitro. In this paper we have shown that estramustine specifically binds MAP-1A in Du 145a cells, resulting in disruption of MAP-1A microtubules and inhibition of type IV collagenase secretion. Immunofluorescence studies revealed that at 30 microM levels estramustine blocked type IV collagenase secretion by partial disruption of the MAP-1A microtubule networks. Immunoprecipitation studies with polyclonal antibodies provided quantitative evidence that 30–60 microM estramustine blocked
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Stearns, M. E., M. Wang, K. D. Tew, and L. I. Binder. "Estramustine binds a MAP-1-like protein to inhibit microtubule assembly in vitro and disrupt microtubule organization in DU 145 cells." Journal of Cell Biology 107, no. 6 (1988): 2647–56. http://dx.doi.org/10.1083/jcb.107.6.2647.

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The twofold purpose of the study was (a) to determine if a MAP-1-like protein was expressed in human prostatic DU 145 cells and (b) to demonstrate whether a novel antimicrotubule drug, estramustine, binds the MAP-1-like protein to disrupt microtubules. SDS-PAGE and Western blots showed that a 330-kD protein was associated with microtubules isolated in an assembly buffer containing 10 microM taxol and 10 mM adenylylimidodiphosphate. After purification to homogeneity on an A5m agarose column, the 330-kD protein was found to promote 6 S tubulin assembly. Turbidimetric (A350), SDS-PAGE, and electr
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&NA;. "Estramustine phosphate sodium." Reactions Weekly &NA;, no. 1312 (2010): 24. http://dx.doi.org/10.2165/00128415-201013120-00084.

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Simpson, Dene, and Antona J. Wagstaff. "Estramustine Phosphate Sodium." American Journal of Cancer 2, no. 5 (2003): 373–90. http://dx.doi.org/10.2165/00024669-200302050-00013.

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Dissertations / Theses on the topic "Estramustine"

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Sangrajrang, Suleeporn. "Analyse de l'action de drogues antimicrotubulaires dans des lignées cancéreuses : rôle de l'hétérogénéité des tubulines et des maps." Paris 11, 1998. http://www.theses.fr/1998PA11T022.

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Analyse de l'action de drogues antimicrotubulaires dans les lignées cancéreuses: rôle de l'hétérogénéité des tubulines et des MAPs. Le cancer de la prostate est un cancer réfractaire à de nombreux médicaments anticancéreux. Cependant une drogue, l'estramustine, moutarde azotée liée à un stéroïde, a montré une activité ami- tumorale significative mais limitée dans le temps, probablement à cause d'un phénomène de résistance acquise résultant du traitement chimiothérapeutique. Il nous est donc apparu important d'étudier les mécanismes qui permettent aux cellules tumorales prostatiques d'échapper
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Jennings, Andrew Melvin. "Reversal of multidrug resistance in bladder cancer cell lines with estramustine and its derivatives." Thesis, University of Portsmouth, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411547.

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Schoultz, Eva von. "Malignant glioma : experimental studies with an estrogen-linked cytostatic." Doctoral thesis, Umeå universitet, Onkologi, 1990. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100558.

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Malignant gliomas are the most common primary brain tumors in adults. Patients with these highly malignant tumors have an extremely poor prognosis. The situation with a highly proliferative tumor in a non-proliferating tissue should favor cytostatic treatment but so far the role of conventional chemotherapy has been adjunctive. The concentrations of three sex steroids, estradiol, progesterone and testosterone, were analyzed by radioimmunoassay after celite chromatography in brain tumor samples. Some malignant gliomas had high tissue concentrations of estradiol. Low progesterone levels may sugg
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Rothaug, Winfried [Verfasser]. "Effekt von Estramustin und Etoposid in Kombination mit dem synthetisch entwickelten Matrix-Metalloproteinase-Inhibitor ICOL-51 auf das Wachstum des Dunning-Tumors in vivo und in vitro / Winfried Rothaug." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1022824791/34.

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Vaz, Marta Filipa Freire. "Avaliação de resposta a Vinorelbina-Estramustina em segunda linha terapêutica, em doentes com carcinoma da próstata hormono-refratário previamente tratados com Docetaxel." Master's thesis, 2014. http://hdl.handle.net/10451/24403.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014<br>Castrate-resistant prostate cancer treatment should be started with chemotherapy or further hormonal treatment. In this study, patients who progressed under docetaxel, treated with vinorelbine-estramustine as second-line approach, were evaluated. Between 2005 and 2013, thirteen patients followed in Santa Maria Hospital´s Oncology department were eligible. We found a biochemical response with PSA reduction of more than 50% in 38,46% and a decrease of PSA between 30% and 50% in 15,38
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Books on the topic "Estramustine"

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Weinstein, Marc A. Inhibition of malignant glial cell growth by estramustine, an estrogen based antimicrotubule agent, and synthesized analogs of estrone, and the basis for the use of estramustine in combination chemotherapy. s.n.], 1993.

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Jennings, Andrew Melvin. Reversal of multidrug resistance in bladder cancer cell lines with estramustine and its derivatives. University of Portsmouth, 2005.

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Book chapters on the topic "Estramustine"

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Mader, Ines, Patrizia E. Fürst-Weger, Robert M. Mader, Elisabeth I. Semenitz, Robert Terkola, and Sabine M. Wassertheurer. "Estramustine." In Extravasation of Cytotoxic Agents. Springer Vienna, 2003. http://dx.doi.org/10.1007/978-3-7091-3710-9_25.

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Mader, Ines, Patrizia Fürst-Weger, Robert Mader, Elisabeth Nogler-Semenitz, and Sabine Wassertheurer. "Estramustine." In Extravasation of Cytotoxic Agents. Springer Vienna, 2010. http://dx.doi.org/10.1007/978-3-211-88893-3_32.

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Kreis, Willi. "Estramustine revisited." In Concepts, Mechanisms, and New Targets for Chemotherapy. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2007-8_8.

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Andersson, Lennart. "Estrogens and Estramustine Phosphate." In The Medical Management of Prostate Cancer. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73238-6_5.

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Björk, P., Å. Fritjofsson, and B. Hartley-Asp. "Uptake and Binding of Estramustine and Estromustine, Metabolites of Estramustine Phosphate (Estracyt), in the Human Prostate, and New Aspects on the Cytotoxic Activity of Estramustine Phosphate In Vitro." In Experimentelle Urologie. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70524-3_49.

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Wood, David P. "Evolving Therapies for Prostatic Carcinoma, Encompassing Orchiectomy, Estrogens, and Estramustine." In Estrogens, Progestins, and Their Antagonists. Birkhäuser Boston, 1997. http://dx.doi.org/10.1007/978-1-4612-2306-1_6.

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Wood, David P. "Evolving Therapies for Prostatic Carcinoma, Encompassing Orchiectomy, Estrogens, and Estramustine." In Estrogens, Progestins, and Their Antagonists. Birkhäuser Boston, 1997. http://dx.doi.org/10.1007/978-1-4612-4096-9_6.

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Inoue, Takahiro. "Role of Estramustine Phosphate and Other Estrogens for Castration-Resistant Prostate Cancer." In Hormone Therapy and Castration Resistance of Prostate Cancer. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-7013-6_26.

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Mader, Ines, Patrizia Fürst-Weger, Robert M. Mader, Elisabeth I. Semenitz, Robert Terkola, and Sabine M. Wassertheurer. "Estramustin." In Paravasation von Zytostatika. Springer Vienna, 2002. http://dx.doi.org/10.1007/978-3-7091-3799-4_25.

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Kalland, T. "Effect of Estramustine Phosphate (Estracyt) and Diethylstilbestrol on Human Natural Killer Cells In Vitro and In Vivo." In Experimentelle Urologie. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70524-3_50.

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Conference papers on the topic "Estramustine"

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Scott, Latanya M., Liwei Chen, Kenyon G. Daniel, et al. "Abstract 3239: Shp2 inhibitor activity of estramustine phosphate and its triterpenoid analogues." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3239.

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Dahmani, Ahmed, Ludmilla De Plater, Charlotte Guyader, et al. "Abstract A27: Efficacy of estramustine + docetaxel in docetaxel‐resistant human prostate cancer xenograft: a preclinical model of docetaxel resistance reversion." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-a27.

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Reports on the topic "Estramustine"

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Volm, Matthew D. 99-Technetium Sestamibi Scanning to Predict the Efficacy of Estramustine Phosphate in Overcoming Paclitaxel Resistance in Patients With Advanced Breast Cancer. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada403456.

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Volm, Matthew D. 99-Technetium Sestamibi Scanning to Predict the Efficacy of Estramustine Phosphate in Overcoming Paclitaxel Resistance in Patients with Advanced Breast Cancer. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada434806.

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Volm, Matthew D. 99-Technetium Sestamibi Scanning to Predict the Efficacy of Estramustine Phosphate in Overcoming Paclitaxel Resistance in Patients with Advanced Breast Cancer. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada392901.

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DiPaola, Robert S., Robert Weiss, and W. J. Shih. A Phase I/II Trial of 13-Cis Retinoic Acid, Alpha Interferon Taxotere, and Estramustine (R.I.T.E.) for the Treatment of Hormone Refractory Prostate Cancer. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada423723.

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