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Dissertations / Theses on the topic 'Estrogeen'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Järvenpää, Paula. "Intestinal metabolism of estrogens including some studies on medroxiprogesterone acetate and megestrol acetate." Helsinki : Finnish Society of Sciences and Letters, 1991. http://books.google.com/books?id=ee5qAAAAMAAJ.

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2

Lee, Isaish Chi Kin. "Measuring the binding kinetics of estrogen receptor alpha and dietary estrogens." HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/28.

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Anti-estrogen drugs such as Tamoxifen and Raloxifene are widely prescribed for breast cancer patients. While they are effective, they also have serious side effects. Alternative drugs are therefore being developed. In the drug discovery process, the in vitro binding of estrogen receptors and lead compounds were studied. The binding strength was conventionally quantified in terms of equilibrium dissociation constants (K0 ). However, the binding kinetic rates and especially off-rates (k0 ff) were recently shown to be better indicators of drug potency. In this thesis, we identified a few dietary

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3

Wade, Christian Bernard. "Mechanisms of estrogen rapid signaling /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/6272.

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4

Scherr, Frank. "Sorption, degradation and transport of estrogens and estrogen sulphates in agricultural soils." Diss., Lincoln University, 2009. http://hdl.handle.net/10182/1017.

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The fate and behaviour of estrogens in the environment are of concern due to the compounds’ endocrine disruption potential. Estrogens, namely 17β-estradiol (E2), estrone (E1), and estrogen sulphates, i.e. 17β-estradiol-3-sulphate (E2-3S) and estrone-3-sulphate (E1-3S) excreted by livestock constitute a potential source for estrogen contamination in the environment. A method was developed to separate and quantify the hormones by high-performance-liquid-chromatography (HPLC) and ultraviolet detection (UV). A combination of dichloromethane (DCM) and dicyclohexylamine hydrochloride (DCH·HCl) gave

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5

Graham, Lisa Anne. "Environmental Estrogens: Assessing Human Gestational Exposure and Interactions with the Estrogen Receptor." Thesis, University of Canterbury. Chemistry, 2012. http://hdl.handle.net/10092/7173.

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Environmental xenoestrogens (EEs) are chemicals that when they enter the body, the body responds to them as it would to endogenous estrogens. Humans are exposed to these chemicals on a daily basis via natural components, additives and contaminants in food and water, through the use of pharmaceuticals and personal care products such as sunscreens, lotions and toothpaste. Exposure to EEs is thought to result in adverse effects on humans such as decreased fertility, increased susceptibility to hormone-sensitive cancers, deformities of the male genitalia and precocious puberty in females. Th

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6

Lambert, K. Chad. "The effects of estrogen signaling in innate and adaptive immune cells /." Free to MU Campus, others may purchase, 2005. http://wwwlib.umi.com/cr/mo/fullcit?p3189934.

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7

Nilsson, Ola. "The role of estrogen in growth plate chondrogenesis /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-410-0/.

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8

Van, Wyk Susan. "The effects of growth stimulants used at cattle feedlots, on reproductive health and thyroid function of Sprague-Dawley rats." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/24885.

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Reports of endocrine disrupting potential of common environmental chemicals and the effects on reproductive health are well documented in literature. It has been suggested that deteriorating male reproductive health could be due to in utero exposures to these chemicals. The effects mediated through endocrine disrupting chemicals (EDCs) are on the fetus and may therefore be trans-generational. Ultimately, these chemicals land up in aquatic systems and affect wildlife and humans. Humans are exposed to these chemicals through multiple routes including atmosphere, water, occupational, domestic and

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9

Zhang, Qiu-Xia. "Estrogen receptor gene alterations in human breast cancer." Lund : Jubileumsinstitutionen, Dept. of Oncology,Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39738537.html.

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10

Linford, Nancy J. "Effects of estrogenic compounds on neuronal apoptotic pathways /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/6289.

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11

Foryst-Ludwig, Anna [Verfasser]. "Obesity-related cardiovascular and metabolic diseases : the role of estrogens, estrogen receptors and PPARgamma / Anna Foryst-Ludwig." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1052530788/34.

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12

Ansell, Peter James. "Regulation of the antioxidant response element by estrogens : a potential mechanism to help explain estrogen-induced cancer? /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3137674.

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13

Stavréus-Evers, Anneli. "Implantation : morphological and biochemical characterization of the receptive human endometrium /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-313-9.

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14

Trauernicht, Amy Michelle. "The role of the deleted in breast cancer 1 gene product, DBC-1, in estrogen-independent breast cancer cell survival : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1407489201&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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15

Harrell, Joshua C. "Dissecting roles of estrogen receptors in breast cancer lymphatic metastasis /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Reproductive Sciences) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 125-140). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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16

Philips, Brian John. "Protein interactions with the catechol estrogens 4-hydroxyestrone and 4-hydroxyestradiol in mouse tissue lysate : binding and metabolism studies /." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3036851.

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17

Constantinidou, Demetra. "Investigation of the role of phosphorylation of the estrogen receptor, its relevance to breast cancer and involvement in resistance to anti-estrogens." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408430.

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18

Orajärvi, M. (Marko). "Effect of estrogen and dietary loading on rat condylar cartilage." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526207377.

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Abstract The temporomandibular joint (TMJ) is a synovial joint which attaches the mandible to the skull. The head of the mandibular condyle is covered by condylar cartilage, which functions as both growth and articular cartilage. Masticatory forces are transmitted to the condylar cartilage, and the consistency of a person’s diet partly defines the loading force. Condylar cartilage acts as a load-absorbing structure together with the articular disc. Temporomandibular disorders (TMDs) are a wide group of pathological conditions involving pain and dysfunction in the masticatory system. Females co

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19

Stygar, Denis. "The impact of estrogens on leukocyte function in remodeling of extracellular matrix /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-572-0/.

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20

Tanemura, Mai. "The role of estrogen and estrogen receptor β in choroidal neovascularization". Kyoto University, 2005. http://hdl.handle.net/2433/144767.

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21

Stewart, Ceri Elisabeth. "Estrogen receptor beta and estrogen response in breast cancer cell lines." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491371.

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Ced Stewart: Estrogen receptor beta and estrogen response in breast cancer cell lines Breast cancer affects 1 in 9 women in Britain and its development and treatment are greatly influenced by hormonal status, such as exposure to endogenous estrogen and expression of estrogen receptors (ERs). ERa is an established prognostic marker in breast cancer, but the role of ERp is less certain. The ERs act to regulate gene transcription via a highly complex variety of mechanisms in response to stimuli such as estrogen, tamoxifen or fulvestrant. In order to further define the role of ERp isoforms in brea

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22

Lau, Kin-Mang. "Estrogen and Antiestrogen Actions on Human Prostate Cancer: A Dissertation." eScholarship@UMMS, 2001. https://escholarship.umassmed.edu/gsbs_diss/37.

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Prostate cancer increases its incidence with age after men in their fifth decade as the ratio of estrogen to androgen rises. Epidemiological studies indicated that high levels of estrogens are associated with the high-risk ethnic groups for prostate cancer. Therefore, estrogens may be involved in prostatic carcinogenesis. It is widely believed that the actions of estrogens are mediated by estrogen receptors. However, expression of estrogen receptor in normal prostate and lesions of the gland was controversial. With the recent discovery of second estrogen receptor (ER-β), this issue became more

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23

Pettersson, Katarina. "Signal transduction via estrogen receptors (ERs) and estrogen receptor-related receptors (ERRs) /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4184-X/.

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24

Lee, Chun-lun. "Actions of estrogen and estrogen-related compounds on prostate cancer cell growth /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38297061.

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25

Lee, Chun-lun, and 李振倫. "Actions of estrogen and estrogen-related compounds on prostate cancer cell growth." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011266.

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26

Karolczak, Magdalena. "Estrogen synthesis and novel mechanisms of estrogen action in the developing brain." Ulm : Universität Ulm, Medizinische Fakultät, 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9394023.

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27

Lee, Annie S. (Annie Sang) 1975. "Molecular mechanism of interactions between estrogen receptor and estrogen receptor selective genotoxins." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/73348.

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Thesis (S.M.)--Massachusetts Institute of Technology, Division of Bioengineering and Environmental Health, 2000.<br>Includes bibliographical references (leaves 43-47).<br>Although one million new breast cancer cases arise each year worldwide, therapies to treat the disease are limited. Conventional treatments including the chemotherapeutic agent, Tamoxifen, have had only limited success, often showing uncomfortable side effects. Our group has proposed a new scheme for a rational drug design. This scheme utilizes recent findings on the mechanism of cisplatin, the drug found to cure in excess of

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28

Andersson, Therése. "Estrogen and Glucocorticoid Metabolism." Doctoral thesis, Umeå universitet, Medicin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33165.

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Background: Cardiovascular disease (CVD) is the leading cause of death among women in Sweden. The risk of CVD increases rapidly after the menopause. A major contributing factor may be the redistribution of adipose tissue, from the peripheral to central depots, associated with menopause. This change in body composition is commonly attributed to declining estrogen levels but may also be affected by tissue-specific alterations in exposure to other steroid hormones, notably glucocorticoids – mainly cortisol in humans. Indeed, adipose tissue-specific overexpression of the glucocorticoid-activating

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29

Ljunggren, Ribom Eva. "Muscles, Estrogen, and Bone." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3779.

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30

Curran, Edward M. "Regulation of the estrogen receptor in human breast cancer cells /." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9901231.

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31

Karolczak, Magdalena [Verfasser]. "Estrogen synthesis and novel mechanisms of estrogen action in the developing brain / Magdalena Karolczak." Ulm : Universität Ulm. Medizinische Fakultät, 2001. http://d-nb.info/1015473156/34.

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32

Islander, Ulrika. "Immunomodulation by estrogen and estren /." Göteborg : Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Göteborg University, 2007. http://hdl.handle.net/2077/3123.

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33

Gagniac, Laurine. "Physiologie et physiopathologie des effets membranaires du récepteur des œstrogènes alpha (ERα) dans la glande mammaire". Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30101.

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It is well established that the 17-estradiol is involved in the development and homeostasis of reproductive and extra-reproductive tissues, particularly the mammary gland. Estradiol classically binds to Estrogen Receptor (ERα), which is a member of the nuclear receptor superfamily. ER mediates nuclear (transcription) and plasma membrane (signaling) ERα function. Interestingly, the membrane initiated steroid signaling (MISS) required a post translational modification of the receptor: palmitoylation of the human Cys-447 or the murine Cys-451 counterpart. The main objectives of my PhD thesis we

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34

Zushin, Peter-James H. "The selective effect of estrogen receptor alpha and beta on activity and social behavior in neonatal male praire voles." Akron, OH : University of Akron, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1248102221.

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Thesis (M.S.)--University of Akron, Dept. of Biology, 2009.<br>"August, 2009." Title from electronic thesis title page (viewed 10/7/2009) Advisor, Bruce Cushing; Committee members, Qin Liu, Todd Blackledge; Department Chair, Monte Turner; Dean of the College, Chand Midha; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.

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35

Russell, Nancy. "Estrogen Receptor Alpha in the Medial Preopic Area Mediates Male Rat Sexual Responses to Estrogen." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_theses/25.

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Male rat sexual behavior requires aromatization of testosterone (T) to estradiol (E2) in the medial preoptic area (MPO) where estrogen receptors (ER) exist in two isoforms, ERα and ERβ. We hypothesized that E2 acts through estrogen receptor α (ERα) in the MPO to promote male mating behavior. Four groups of male rats were castrated, administered DHT s.c. and bilateral MPO implants delivering either: cholesterol, E2, propyl pyrazole triol (PPT, ERα agonist), diarylpropionitrile (DPN, ER β agonist), or 1-methyl-4-phenyl pyridinium (MPP, ERα antagonist). Additional gonadally intact males received

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36

Couse, John Floyd. "THE ROLE OF ESTROGEN RECEPTOR-a AND ESTROGEN RECEPTOR-b IN THE HYPERLUTEINIZED MOUSE OVARY." NCSU, 2004. http://www.lib.ncsu.edu/theses/available/etd-05212004-123339/.

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The hypothalamic-pituitary-gonadal (HPG) axis was characterized in female mice lacking one or both forms of estrogen receptor (ERa, ERb) with the aim of elucidating the contribution of each receptor form to gonadotropin homeostasis and ovarian function. These studies consisted of a thorough evaluation of gene expression for the gonadotropin subunits in the pituitary and the components necessary for steroidogenesis in the ovary. These data were corroborated with evaluations of the plasma levels for each of the relevant pituitary and gonadal hormones. Females lacking ERb (bERKO) exhibit minimal

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37

Shen, Minqian. "Roles of estrogen hormones and estrogen receptors on regulation of liver and liver cancer metabolism." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami1492612390075921.

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38

Björnström, Linda. "Molecular mechanisms of alternative estrogen receptor signaling /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-509-3/.

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39

Toll, Karin. "Pregnancy rhinitis : pathophysiological effects of oestrogen and treatment with oral decongestants /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-358-0/.

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40

Rafi, Ali. "Estrogen action in growth plate cartilage." Thesis, Högskolan i Skövde, Institutionen för vård och natur, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-5463.

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41

Park, Se Hyung. "Estrogen in ovarian cancer cell metastasis." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1287.

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Benign ovarian tumors and majority of epithelial ovarian cancers possess steroid receptors including estrogen receptors (ERs). However, the estrogen-ER signaling in ovarian carcinomas is not completely understood. Tumorigenesis is a multiple-step process involving dysregulated cell growth and metastasis. Tumor cells acquire the capacity of migration and invasion by temporal phenotypical and genotypical changes termed epithelial-mesenchymal transition (EMT). Considerable evidence implicates a mitogenic action of estrogen in early ovarian carcinogenesis. In contrast, its influence in the metasta

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42

Eng, Frank Chung Sing 1972. "Molecular mechanisms of estrogen receptor signaling." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38483.

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The estrogen receptor (ER) is a ligand dependent transcriptional activator that belongs to the steroid/nuclear receptor superfamily. To probe the structure and function of the ER ligand binding domain (LBD), we developed a genetic screen in yeast Saccharomyces cerevisiae using a library of reverse ERs screened with a low affinity estrogen agonist, 2-methoxyestrone. Mutants isolated from this screen demonstrated altered ligand binding and/or transactivation properties. One of these mutants, L536P, showed high levels of constitutive activity in several transiently transfected cells and a HeLa li

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43

Greiwe, Kelly. "Effects of estrogen on aggressive behavior." Connect to resource, 2006. http://hdl.handle.net/1811/6576.

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Thesis (Honors)--Ohio State University, 2006.<br>Title from first page of PDF file. Document formatted into pages: contains 18 p.; also includes graphics. Includes bibliographical references (p. 16-18) Available online via Ohio State University's Knowledge Bank.

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44

Mhyre, Andrew James. "Mechanisms of estrogen signaling in astrocytes /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/6266.

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45

Heldring, Nina. "Molecular basis of estrogen receptor antagonism /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-634-4/.

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46

Singer, Cherie A. "Neurotrophic and neuroprotective effects of estrogen /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/6301.

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47

Jain, Disha. "New approaches to estrogen receptor modulation." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 157 p, 2009. http://proquest.umi.com/pqdweb?did=1818417411&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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48

Nelson, Adam William. "Estrogen receptor beta modulates prostate carcinogenesis." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267736.

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Prostate cancer (PC) is characterised by dependence upon androgen receptor (AR) as its driving oncogene. When organ-confined, radical treatment can be curative, however there is no cure for advanced, castration-resistant prostate cancer (CRPC). There is therefore a need to better understand the biology of PC, and how influencing AR can modify disease progression. Estrogen is essential for prostate carcinogenesis with evidence from epidemiological, in vitro, human tissue and animal studies. Most suggests that estrogen receptor beta (ERβ) is tumour-suppressive, but trials of ERβ-selective agents

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49

Mobley, James Austin. "Oxidative mechanisms of estrogen induced carcinogenesis /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu148819623490807.

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50

Zilmer, Johansen Anne Katrine. "Estrogen metabolism in pulmonary arterial hypertension." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5199/.

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Pulmonary arterial hypertension (PAH) is a devastating and progressive vasculopathy of the pulmonary arteries for which there is no cure. There is an urgent need for more effective therapies. PAH is characterised by elevated pulmonary arterial pressures and obstructive vascular lesions in the distal vasculature by excessive cellular proliferation. As a result, the right ventricle is placed under excessive strain resulting in adaptive hypertrophy which progresses to maladaptive hypertrophy and failure. PAH is more common in women than in men suggesting that estrogens may be integral to disease

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