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Dissertations / Theses on the topic 'Estrogen (17β estradiol)'

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Published: 3 June 2025
Last updated: 31 July 2025

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1

Brummer, Tyson Peter Thomas. "Comparative Immunological Effects of a Natural Estrogen (17β-estradiol) versus a Pharmacologic Synthetic Estrogen (17α-ethinyl estradiol)". Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/34601.

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Exposure to exogenous estrogens such as synthetic 17α-ethinyl estradiol (EE) occurs via multiple sources (i.e. hormonal contraceptives, environmental contamination, hormone replacement therapy). The natural estrogen, 17β-estradiol (E2), is a well-studied immunomodulatory hormone at both environmental and pharmacologic levels. Conversely, little data exist regarding the immune effects of EE at either environmentally-relevant exposure levels or at pharmacological levels. Further, EE is delivered to patients in a clinical setting via different routes of exposure (e.g. subcutaneous or oral).
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2

LE, HOA HIEN. "Definition of Rapid 17β-Estradiol Signaling Networks in Developing Cerebellar Granule Cells". University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1218807307.

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3

Shrestha, Suman Lal. "Fate and Transformation of a Conjugated Natural Hormone 17β-Estradiol-3-Glucuronide in Soil-Water Systems". Diss., North Dakota State University, 2011. https://hdl.handle.net/10365/29317.

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The objectives of the study were to investigate the sorption and degradation of a glucuronide conjugated natural hormone, 17β-estradio1-3-glucuronide (E2-3G), and its estrogenic metabolites in soil-water systems. Radiolabeled E2-3G was first synthesized in the laboratory. Soil-water batch experiments were then conducted using natural and sterilized topsoil (0-6 cm) and subsoil (18-24 cm) with the radiolabeled E2-3G to investigate the effects of soil organic matter content and microbial activity. The aqueous dissipation of 14C in the batch experiments followed a biphasic pattern with an initial
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4

Qin, Chao. "Mineral Surface Catalyzed Polymerization Of Estrogen And Microbial Deactivation By Fe3+-Saturated Montmorillonite: A Potentially Low Cost Material For Water Decontamination." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/84467.

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With advantages of high cation exchange capacity, swelling-shrinking property and large specific surface area, monmtorillonite is chosen as a carrier and modified with Fe3+ saturation for estrogen decontamination. 17β-Estradiol (βE2) has highest estrogenic activity among estrogens and is selected as representative compound. Rapid βE2 transformation in the presence of Fe3+ - saturated montmorillonite in aqueous system was observed and βE2 oligomers were the major βE2 transformation products. About 98% of βE2 were transformed into oligomers which are >107 times less water-soluble than βE2 and th
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5

Strand, Magnus. "Estrogen signaling in stroke : genetic and experimental studies." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1397.

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6

Bai, Xuelian. "Fate and Transport of an Estrogen Conjugate 17ß-Estradiol-17-Sulfate in Soil-Water Systems." Diss., North Dakota State University, 2013. https://hdl.handle.net/10365/27136.

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The hypothesis of this study was that a sulfate conjugated estrogen, i.e. 17β-estradiol-17- sulfate (E2-17S), could be a precursor to free estrogens detected in the environment. The objectives of were to investigate the fate and transport processes of E2-17S in various soil-water systems. Radiolabeled E2-17S was synthesized using a series of chemical for the subsequent soil batch experiments. The batch experiment results showed that E2-17S dissipated more quickly from the aqueous phase of the topsoil compared to the subsoil, demonstrating that soil organic carbon played a significant role. The
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7

Scherr, Frank. "Sorption, degradation and transport of estrogens and estrogen sulphates in agricultural soils." Diss., Lincoln University, 2009. http://hdl.handle.net/10182/1017.

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The fate and behaviour of estrogens in the environment are of concern due to the compounds’ endocrine disruption potential. Estrogens, namely 17β-estradiol (E2), estrone (E1), and estrogen sulphates, i.e. 17β-estradiol-3-sulphate (E2-3S) and estrone-3-sulphate (E1-3S) excreted by livestock constitute a potential source for estrogen contamination in the environment. A method was developed to separate and quantify the hormones by high-performance-liquid-chromatography (HPLC) and ultraviolet detection (UV). A combination of dichloromethane (DCM) and dicyclohexylamine hydrochloride (DCH·HCl) gave
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8

Cookman, Clifford. "Characterization of 17ß-Estradiol Survival Signaling in Medulloblastoma: Relation to Tumor Growth and IGF1 Signaling." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447158097.

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9

Nadal, Serrano Mercedes. "Efectos de los Estrógenos, la Genisteína y la Leptina sobre el Estrés Oxidativo en el Cáncer de Mama. Importancia de la UCP2." Doctoral thesis, Universitat de les Illes Balears, 2014. http://hdl.handle.net/10803/284237.

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El estrés oxidativo es un desequilibrio entre la producción de radicales libres y los sistemas antioxidantes encargados de su neutralización. El resultado de este desequilibrio es la acumulación de daños en diversas estructuras celulares incluyendo el DNA. El cáncer se acompaña de un mayor estrés oxidativo a nivel celular, por este motivo, muchos de los tratamientos terapéuticos van dirigidos a aumentar los niveles citotóxicos de ROS, conduciendo a la célula tumoral a la apoptosis. Sin embargo, durante la tumorigénesis las células van adquiriendo una serie de características que permiten mante
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10

Jijana, Abongile Nwabisa. "Quantum dot sensitized estrogen receptor alpha-recombinant protein electrochemical biosensor for 17-beta estradiol." Thesis, University of the Western Cape, 2016. http://hdl.handle.net/11394/5330.

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Philosophiae Doctor - PhD<br>Estrogens play an extraordinary role in the endocrine system regulation through the stimulation and regulation of endocrine pathways. 17β-estradiol is one of the final metabolites in estrogen regulation by hydroxylase enzymes that are well recognized for their metabolic role in hormone fragmentation and dissociation, through hydroxylation reactions that reversibly convert a series of androgens to estrogens (i.e. or one estrogen to the other). However, the 17β-estradiol hormone has been classified as one of the estrogenic endocrine disrupting compounds {i.e. EDC (s)
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11

Bai, Xuelian. "Fate and Transport of an Estrogen Conjugate 17?-Estradiol-17-Sulfate in Soil-Water Systems." Diss., North Dakota State University, 2013. https://hdl.handle.net/10365/27136.

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The hypothesis of this study was that a sulfate conjugated estrogen, i.e. 17?-estradiol-17- sulfate (E2-17S), could be a precursor to free estrogens detected in the environment. The objectives of were to investigate the fate and transport processes of E2-17S in various soil-water systems. Radiolabeled E2-17S was synthesized using a series of chemical for the subsequent soil batch experiments. The batch experiment results showed that E2-17S dissipated more quickly from the aqueous phase of the topsoil compared to the subsoil, demonstrating that soil organic carbon played a significant role. The
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12

Vihma, Veera. "Lipoprotein-associated 17b[beta]-estradiol fatty acid esters in pregnancy and during postmenopausal estrogen therapy." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/vihma/.

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13

Cao, Qiming. "Behaviour and Health Risk Assessment of Endocrine Disrupting Chemicals from Wastewater." Thesis, Griffith University, 2010. http://hdl.handle.net/10072/365513.

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Water supply has become a social and economic issue in many countries as a result of global climate change, fast population growth, industrial and urban development. To address this issue, water recycling has been considered as a feasible technology to supplement the existing water supply. However, a major challenge with water recycling is the removal of harmful contaminants to meet drinking water guidelines and industrial requirements. Although various technologies can remove most contaminants efficiently, recent studies have shown that many endocrine disrupting chemicals (EDCs) can cause adv
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14

Kendziorski, Jessica A. "Characterization of Endocrine Disrupting Effects of Bisphenol A or 17α-Ethinyl Estradiol in Mouse Uterus". University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447689233.

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15

Park, Danielle Morello [UNESP]. "Influência do estrógeno (17B-estradiol) no osso alveolar e na movimentação dentária em ratas, após remoção do aparelho ortodôntico." Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/95811.

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Made available in DSpace on 2014-06-11T19:27:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2004-03-01Bitstream added on 2014-06-13T19:56:55Z : No. of bitstreams: 1 park_dm_me_arafo.pdf: 1747236 bytes, checksum: ddf8c7542e229e017862e37608d671dc (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A reabsorção óssea é um fator limitante que determina o grau de movimentação dentária induzida ortodonticamente. Vários hormônios, dentre os quais os estrógenos desempenham importante papel no equilíbrio entre formação e reabsorção óssea. Embora alguns trabalhos demo
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16

Jijana, Abongile Nwabisa. "Development of electrochemical ZnSe Quantam dots biosensors for low-level detection of 17β-Estradiol estrogenic endocrine disrupting compound". Thesis, University of the Western Cape, 2010. http://hdl.handle.net/11394/2310.

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Magister Scientiae - MSc<br>The main thesis hub was on development of two electrochemical biosensors for the determination of 17β-estradiol-estradiol: an estrogenic endocrine disrupting compound. Endocronology have significantly shown that the endocrine disruptors contribute tremendously to health problems encountered by living species today, problems such as breast cancer, reproductive abnormalities, a decline in male population most significant to aquatic vertebrates, reduced fertility and other infinite abnormalities recurring in the reproductive system of mostly male species. The first bio
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17

Park, Danielle Morello. "Influência do estrógeno (17B-estradiol) no osso alveolar e na movimentação dentária em ratas, após remoção do aparelho ortodôntico /." Araraquara : [s.n.], 2004. http://hdl.handle.net/11449/95811.

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Resumo: A reabsorção óssea é um fator limitante que determina o grau de movimentação dentária induzida ortodonticamente. Vários hormônios, dentre os quais os estrógenos desempenham importante papel no equilíbrio entre formação e reabsorção óssea. Embora alguns trabalhos demonstrem relação direta entre os estrógenos e a movimentação ortodôntica, a influência destes hormônios na movimentação dentária após remoção do aparelho ortodôntico e na estrutura óssea alveolar durante esta fase ainda não foi esclarecida. Sendo a manutenção da estabilidade dental pós-tratamento ortodôntico essencial para o
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18

Abbas, Hesham Magdi. "Estrogenic Compounds Protect Rat Cardiac Myoblasts (H9c2 Cells) Against Doxorubicin-Induced Cell Death." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd_retro/131.

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The antineoplastic drug doxorubicin is widely used in the treatment of various types of cancers including breast, colon and lung cancer. However, doxorubicin has adverse effects on the heart and prolonged doxorubicin administration results in cardiomyopathy and congestive heart failure. In the present study we have established that treatment of rat cardiac myoblasts (H9c2 cells) for 24 hours with doxorubicin resulted in concentration and time dependent cell death as determined by proliferation assay. Almost 50-55% cell death was attained at 24 hours treatment of H9c2 cells with 5 μM doxorub
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19

Shrestha, Suman Lal. "Fate and Transformation of a Conjugated Natural Hormone 17?-Estradiol-3-Glucuronide in Soil-Water Systems." Diss., North Dakota State University, 2011. https://hdl.handle.net/10365/29317.

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The objectives of the study were to investigate the sorption and degradation of a glucuronide conjugated natural hormone, 17?-estradio1-3-glucuronide (E2-3G), and its estrogenic metabolites in soil-water systems. Radiolabeled E2-3G was first synthesized in the laboratory. Soil-water batch experiments were then conducted using natural and sterilized topsoil (0-6 cm) and subsoil (18-24 cm) with the radiolabeled E2-3G to investigate the effects of soil organic matter content and microbial activity. The aqueous dissipation of 14C in the batch experiments followed a biphasic pattern with an initial
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20

LA, SALA GINA. "Effetti degli estrogeni e dei distruttori endocrini sulle cellule germinali embrionali di topo e sulle cellule somatiche della gonade." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/901.

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Negli ultimi anni si è assistito ad un crescente aumento nell’ambiente di sostanze che sono in grado di alterare il sistema endocrino poiché agiscono come l’ormone naturale estrogeno e per questo definite distruttori endocrini (EDs). Si ipotizza che l’esposizione agli EDs durante il periodo fetale e neo-natale sia la causa dell’insorgenza di numerosi disordini dell’apparato riproduttivo maschile come sterilità, cancro del testicolo, criptorchidismo e ipospadia che vengono definite con il termine unico di sindrome del testicolo disgenico (TDS). E’ importante studiare gli effetti degli estrogeni
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21

Sherbet, Daniel P. "Structural and physiologic determinants of estrone/estradiol metabolism catalyzed by human 17b-hydroxysteroid dehydrogenases types 1 and 2." Access to abstract only; dissertation is embargoed until after 7/13/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=178.

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22

Rosa-Ribeiro, Rafaela 1987. "Regressão prostática pós-castração : caracterização das alterações causadas pela privação androgênica e alta dose de 17ß- estradiol." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317554.

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Orientador: Hernandes Faustino de Carvalho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-21T07:59:39Z (GMT). No. of bitstreams: 1 Rosa-Ribeiro_Rafaela_M.pdf: 2991640 bytes, checksum: 1c3d98622022906218832c47353b3c63 (MD5) Previous issue date: 2012<br>Resumo: O desenvolvimento, a fisiologia e o câncer de próstata dependem de balanços entre os níveis de andrógenos e estrógenos, que agem via receptor de andrógenos (AR) e receptores de estrógeno (ER'alfa' e ER'beta'), respectivamente. Sabe-se que a cinética de morte da
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23

Sahin, Ebru Karpuzoglu. "Estrogen Regulates Interferon-gamma (IFN-g) and IFN-g-Inducible iNOS Gene Expression: Implications to Immunity and Autoimmunity." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/27129.

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It is now clear that estrogen not only modulates the differentiation and function of reproductive systems, but it also profoundly regulates the immune system of normal and autoimmune individuals. An important mechanism by which estrogen regulates the immune system is by altering the secretion and/or response to cytokines. We hypothesized that estrogen may alter the levels and/or response to IFN-g, a prototype Th1 cytokine, that plays a pivotal role in immunity against intracellular infections and in many autoimmune and inflammatory disorders. We found that estrogen treatment tended to upregula
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24

Wender, Maria Celeste Osório. "Uso do estradiol-17 beta percutâneo em pacientes pós-menopáusicas hipertensas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 1993. http://hdl.handle.net/10183/171316.

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25

Passini, Gabriel. "Indução da inversão sexual de machos do robalo-flecha, Centropomus undecimalis, com implantes do hormônio 17-B estradiol." reponame:Repositório Institucional da UFSC, 2013. https://repositorio.ufsc.br/handle/123456789/106919.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Aqüicultura, Florianópolis, 2013<br>Made available in DSpace on 2013-12-05T22:44:20Z (GMT). No. of bitstreams: 1 317597.pdf: 4081872 bytes, checksum: ffa4037c632740fd4461737001112393 (MD5) Previous issue date: 2013<br>O robalo-flecha (Centropomus undecimalis) é um hermafrodita protândrico e um dos entraves para a reprodução em laboratório é a captura e manutenção das fêmeas. O objetivo deste estudo foi avaliar o efeito de implantes do hormônio 17-? estradiol (E2) para in
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26

Silva, Paulo Rogério Martins da. "Remoção de atividade estrogênica do hormônio 17β-Estradiol em processos de oxidação de águas para abastecimento." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-11052016-103944/.

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Muitos oxidantes químicos reativos acarretam na ruptura de estruturas moleculares complexas de vários tipos de compostos orgânicos decompondo-as em estruturas mais simples e propiciando condições melhores para uma efetiva ação de micro-organismos na degradação biológica. A presença de hormônios, entre eles o 17&beta;-estradiol, em estações de tratamento de esgoto e em águas subterrâneas e superficiais mostra a necessidade de uma avaliação dos processos de tratamento convencionais. O objetivo deste trabalho foi a análise e remoção de hormônios através de técnicas de cloração e ozonização de amo
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27

Mezughi, Khaled M. "Heterogeneous photocatalytic degradation of organic pollutants in water over nanoscale powdered titanium dioxide. The photocatalytic degradation of organic compounds in water (Reactive Orange 16, Triclocarbon, Clopyralid and Estrogens (estrone, 17ß-estradiol, and 17α-ethinylestradiol)) was studied; the reaction kinetics and the effect of the operating parameters on the performance of the system were determined; a comparison with other advanced oxidation processes (O3, H2O2, UV) was also made". Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4865.

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Organic contaminants from industrial and/or domestic effluents may be harmful to humans directly or indirectly by degrading the quality of the aquatic environment. Consequently these contaminants must be reduced to levels that are not harmful to humans and the environment before disposal. Chemical, physical and biological methods exist for the removal of these pollutants from effluents. Among the available chemical methods, heterogeneous photocatalytic oxidation has been found particularly effective in removing a large number of persistent organics in water. In this study, photocatalytic degra
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28

Silva, Carla Patrícia Gonçalves. "Occurrence and fate of estrogens and antibiotics in the environment evaluated by low-cost analytical methodologies." Doctoral thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14131.

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Doutoramento em Química<br>Endocrine disruptors and pharmaceuticals are considered to be concerning environmental contaminants. During the last two decades, studies dealing with the occurrence and fate of these emerging contaminants in the aquatic environment have raised attention and its number is constantly increasing. The presence of these contaminants in the environment is particularly important since they are known to induce adverse effects in the ecosystems even at extremely low concentrations. Estrogens and antibiotics, in particular, are identified as capable of induce endocrin
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29

Skauen, Guri Eriksrød. "Effects of melatonin and cortisol on vitellogenin and estrogen receptor α mRNA expression in 17β-estradiol stimulated Atlantic salmon (Salmo salar) hepatocytes." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-23289.

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Knowledge regarding the influence of external and internal factors on teleost fecundity may contribute to increased production and efficiency in aquaculture.Teleost plasma cortisol levels may be elevated in response to stress, potentially affecting reproduction through a negative impact on vitellogenesis. Melatonin (MEL), on the other hand, is shown to have protective effects in organisms, and large amounts of MEL has been observed in the gastrointestinal tract (GIT) in various species, hence finding its way to the liver.The subject of this thesis was to document the MEL concentration in Atlan
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30

Martins, Danieli Brolo. "17-β Estradiol e resveratrol nos parâmetros bioquímicos e hematológicos de ratas ovariectomizadas submetidas a desmielinização pelo brometo de etídio". Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/4067.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Among the neurodegenerative diseases those involving the demyelination of the nervous system, such as multiple sclerosis (MS) that affects young and middle-aged adults, have great importance. Thus, the goal of this study was to evaluate 17-β estradiol and resveratrol as promising substances due to their antioxidant and anti-inflammatory actions, in the neuronal and non-neuronal cholinergic system, hematologic and behavioral parameters in ovariectomized rats under or not the demyelination by ethidium bromide (EB). In the article, an
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31

Stirnemann, Bruno. "Effets estrogéniques sur la motricité de l'utérus et anti-estrogénique sur des récepteurs stéroïdiens d'un anti-estrogène, le 4-hydroxytamoxifène, chez la rate a mi-gestation." Rouen, 1996. http://www.theses.fr/1996ROUES066.

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Par une étude électromyographique, avec des électrodes bipolaires insérées de manière chronique dans le myomètre aux deux extrémités de la corne utérine, nous avons montré que l'activité électrique était faible et asynchrone, à mi-gestation chez la rate. Ces résultats ont été corrélés aux taux élevés de progestérone et des récepteurs de la progestérone et aux taux bas de l'estradiol-17β et de ces récepteurs, mis en évidence par des techniques de radio-immunologie et de compétition. Une anti-hormone, le 4-hydroxytamoxifène, s'est révélé être un anti-estrogène en engendrant une chûte du nombre d
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32

Mezughi, Khaled M. "Heterogeneous photocatalytic degradation of organic pollutants in water over nanoscale powdered titanium dioxide : the photocatalytic degradation of organic compounds in water (Reactive Orange 16, Triclocarbon, Clopyralid and Estrogens (estrone, 17ß-estradiol, and 17α-ethinylestradiol)) was studied : the reaction kinetics and the effect of the operating parameters on the performance of the system were determined; a comparison with other advanced oxidation processes (O₃, H₂O₂, UV) was also made". Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4865.

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Organic contaminants from industrial and/or domestic effluents may be harmful to humans directly or indirectly by degrading the quality of the aquatic environment. Consequently these contaminants must be reduced to levels that are not harmful to humans and the environment before disposal. Chemical, physical and biological methods exist for the removal of these pollutants from effluents. Among the available chemical methods, heterogeneous photocatalytic oxidation has been found particularly effective in removing a large number of persistent organics in water. In this study, photocatalytic degra
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33

Olowu, Rasaq Adewale. "Impedimetric and electrode kinetic dynamics of DNA aptamer nanobiosensors for estrogeneous endocrine disruptors." University of the Western Cape, 2011. http://hdl.handle.net/11394/8455.

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Philosophiae Doctor - PhD<br>In this work, DNA aptamer biosensor systems were developed for the detection of l7p-estradiol - an estrogeneous endocrine disrupting chemical (EDC). Endocrine disrupting chemicals are group of compounds that impact negatively on the endocrine system of humans and wildlife. High concentrations of l7p-estradiol in water or food chain disrupts the physiology of the endocrine system of various animal species, leading to feminisation in fish and stimulates the proliferation of cancer cells in humans. Aptasensor systems for the determination of l7pestradiol were prepared
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34

Guimarães, Tatiane Sant\'Ana. "Detecção e quantificação dos hormônios sexuais 17 \'beta\'-estradiol (E2), estriol (E3), estrona (E1) e 17 \'alfa\'-etinilestradiol (EE2) em água de abastecimento: estudo de caso da cidade de São Carlos, com vistas ao saneamento ambiental." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-26022009-100015/.

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Um dos grandes problemas da engenharia ambiental é a contaminação dos corpos hídricos. Os sanitaristas têm se preocupado com os hormônios sexuais, notadamente os estrógenos, compostos extremamente ativos biologicamente, que têm sido referidos como agentes etiológicos de feminilização e de vários tipos de cânceres. Os estrógenos naturais 17 \'beta\'-estradiol (E2), estriol (E3), estrona (E1) e o sintético 17 \'alfa\'-etinilestradiol (EE2), desenvolvidos para uso médico em terapias de reposição hormonal feminina e métodos contraceptivos, são os que despertam maiores preocupações, pela contínua i
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35

BOLAMPERTI, SIMONA. "ESTROGEN- GROWTH HORMONE INTERACTION IN BONE CELLS OF THE OSTEOGENIC LINEAGE: GROWTH HORMONE ANABOLIC ACTIVITY ON HUMAN OSTEOBLASTS AND THEIR MESENCHYMAL PRECURSORS IS MODULATED BY 17ΒETA-ESTRADIOL THROUGH A POST RECEPTOR MECHANISM." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229429.

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In aging the loss of bone mass goes along with a decline of 17beta-estradiol (E2) and Growth Hormone (GH), which are known to be bone anabolic factors. Recent evidence demonstrated in several cell lines an interplay between E2 and GH at a post receptor level. I thus evaluated the possible cross-talk between these two hormones in human osteoblast cells (hOBs) in primary culture and in their mesenchymal precursors (hMSCs). E2 (10-8M) given 60 min before GH (5ng/ml) enhanced both GH intracellular pathway in hOBs and the transcription of the evaluated GH target genes involved in osteoblast activ
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Maroga, Mboula Vanessa. "Devenir de polluants émergents lors d'un traitement photochimique ou photocatylitique sous irradiation solaire." Phd thesis, Ecole des Mines de Nantes, 2012. http://tel.archives-ouvertes.fr/tel-00779791.

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L'industrialisation et l'utilisation dans la vie courante d'un nombre croissant de produits chimiques et médicamenteux sont responsables de la dissémination dans l'environnement de substances variées nommées" polluants émergents ". Les traitements des eaux usées existants ne sont pas conçus pour éliminer cette catégorie de pollution et les polluants émergents sont alors rejetés dans le milieu récepteur. Une possible solution pour limiter le rejet de ces composés par les effluents de station d'épuration serait l'utilisation de procédés de traitement additionnels tels que les procédés d'oxydatio
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37

Marchiori, Ana Carolina. "Efeitos do 17-estradiol e da lâmina na regulação da expressão dos genes DDEF2 e PHLDA1 em linhagens de células derivadas de adenocarcinomas de mama MCF-7 e MDA-MB-231." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-06052009-165120/.

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O câncer de mama é a doença maligna mais comum e a principal causa de morte entre as mulheres. Sua complexa etiologia envolve múltiplos fatores de risco, a maioria deles relacionada aos níveis cumulativos de exposição da mama aos estrógenos. A maioria de suas ações é mediada pela ligação a seus receptores ER e ER que são fatores de transcrição. Outro fator que exerce um controle extraordinário no comportamento celular, regulando a transcrição gênica e influenciando diversos processos biológicos, e que, quando alterado, é associado ao processo de tumorigênese da mama é a matriz extracelular. A
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Rajoelina, Ratsimba Razan Lalaoarisoa. "La protéine de liaison du 17 bêta œstradiol chez saccharomices cerevisiae : caractères physico-chimiques et essais de purification." Nancy 1, 1987. http://www.theses.fr/1987NAN10355.

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39

Schlecht, Christiane [Verfasser]. "Untersuchung endokriner Effekte von Benzophenon-2 und 17β-Estradiol [17-beta-Estradiol] in estrogen-rezeptiven Organen / vorgelegt von Christiane Schlecht". 2006. http://d-nb.info/98214427X/34.

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Schlecht, Christiane. "Untersuchung endokriner Effekte von Benzophenon-2 und 17β-Estradiol in estrogen-rezeptiven Organen". Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-AC63-3.

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Choudhury, Nasreen. "G-Protein Coupled Estrogen Receptor (hGPER)- Mediated Action of 17β-Estradiol on hTREK-1 Potassium Channel". Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4159.

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TREK-1 is a two-pore domain potassium channel that contributes to maintenance of the resting membrane potential of a cell. TREK-1 is involved in several physiological and pathophysiological conditions like nociception, anaesthesia, epilepsy, ischemia and depression. Activity of TREK-1 is modulated by a number of physical and chemical stimuli including the activation of G-protein coupled receptors by several neurotransmitters and hormones. An important modulator of neuronal activity and function is 17β-estradiol, which by acting through its classical receptors ERα and ERβ, can bring about genom
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Wei, Zong-Yu, та 韋宗佑. "nhibition of ROS-stimulated _JNK/NF-kB_ Signaling by 17β-Estradiol / Estrogen Receptor-α Supresses HG-induced cardiac apoptosis". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/72395103933452088062.

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碩士<br>中國醫藥大學<br>生物科技學系碩士班<br>100<br>Clinical studies have demonstrated that the rate of premenopausal women suffering from cardiac hypertrophy-related disease is significantly lower than that of men at the same age. However, once into the menopause, the rate of postmenopausal women suffering from cardiac diseases has substantially increased. Therefore, estrogen might play an important role on cardiac protection. However, the mechanism of which estrogen and estrogen receptor protect the heart is still unclear. In this study, we investigate the effects of antiapoptosis by 17β-estradiol and/or e
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Ji-Ching та 賴吉慶. "The impact of 17β-estradiol and p53 status on promoter hypermethylation of O6-methylguanine-DNA methyltransferase and estrogen receptor genes during lung tumorigenesis". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/22537296768113120785.

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博士<br>中山醫學大學<br>醫學分子毒理學研究所<br>95<br>The estrogen receptor (ER) transcription silencing due to hypermethylation has been documented to link with the tumor progression of breast, uterine, and prostate cancers. However, the role of hypermethylation-induced ER transcription silencing in lung tumor progression, and its prognostic value for non-small cell lung cancer (NSCLC) patients remained unclear. In the present study, ER hypermethylation of 123 lung tumors and adjacent normal parts were examined by methylation-specific PCR (MSP), and ER mRNA expression in lung tumors were determined by reverse
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Huang, I.-Ta, та 黃奕達. "Investigation of 17β-estradiol-stimulated Intracellular Calcium Changes and Immunosuppressive Responses in Human T cells and Mononuclear Cells by Membrane Estrogen Receptor GPR30". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/21075135673825745098.

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碩士<br>國立陽明大學<br>生理學研究所<br>99<br>Estrogen promotes not only the development of female reproductive system but also the maintenance of secondary sexual characteristics. Moreover, it can immunosuppress T cell activation and release the inflammatory reactions. In our previous reports, estradiol (E2) does not stimulate intracellular pH changes but rapidly stimulates the increase of intracellular free calcium concentration ([Ca2+]i) and the immunosuppression of phytohemagglutinin (PHA)-induced cytokine secretion and proliferation in human peripheral T cells. Recently, G protein-coupled receptor 30
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Wu, Chun-Hsien, та 吳俊賢. "Part I Inhibitory effects of Solanum Lyratum Thunb on Angiotensin II-induced cardiac apoptosis and hypertrophy、Part II The inhibitory effects of 17β-estradiol and/or estrogen receptor α on ZAK-induced apoptosis in H9c2 cell line". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/92322952412824195636.

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碩士<br>中國醫藥大學<br>生物科技學系碩士班<br>97<br>Part 1 Angiotensin II (Ang II) is a very important inducer of cardiovascular disease and may cause cardiac apoptosis and hypertrophy. We used a valued Chinese traditional medicine, Solanum lyratum Thunb (SLT), to evaluate its therapeutic effect on Ang II-induced cardiac apoptosis and hypertrophy. SLT is well known for regulating immune system. It is also reported to exert the functions of anti-oxidation and anti-inflammation; some constituents of SLT have been treated in congestive heart failure and arrhythmia. However, the related mechanisms are not known ye
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(李振宇), Chen-Yu Lee, та 李振宇. "Part I The coexistence of aging and obesity additively increase hypertrophic, apoptotic, and fibrotic signalings in Zucker rat hearts Part II The inhibitory of 17β-estradiol (E2) on ZAK-induced hypertrophy via estrogen receptor α in H9c2 cell lin". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/37157722944674238565.

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碩士<br>中國醫藥大學<br>生物科技學系<br>96<br>Cardiac Remodeling hypertrophy, apoptotic, fibrosis and survival signalings were involved in obesity, but details regarding the cardiac molecular mechanism in the aging effect in obesity were not available. The purpose of this study was to evaluate whether the aging obesity will additively influence the hypertrophic, apoptotic, fibrotic and survival pathways. Eleven young lean (YL), 10 young obese (YO), 11 old lean (OL), and 11 old obese (OO) Zucker rats were investigated at 4 and 14 months old. The cardiac characteristics, apoptotic, hypertrophic, and fibrosis
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(李振宇), Chen-Yu Lee, та 李振宇. "Part I The coexistence of aging and obesity additively increase hypertrophic, apoptotic, and fibrotic signalings in Zucker rat hearts Part II The inhibitory of 17β-estradiol (E2) on ZAK-induced hypertrophy via estrogen receptor α in H9c2 cell line". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/87159961862899722814.

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碩士<br>中國醫藥大學<br>生物科技學系碩士班<br>96<br>Cardiac Remodeling hypertrophy, apoptotic, fibrosis and survival signalings were involved in obesity, but details regarding the cardiac molecular mechanism in the aging effect in obesity were not available. The purpose of this study was to evaluate whether the aging obesity will additively influence the hypertrophic, apoptotic, fibrotic and survival pathways. Eleven young lean (YL), 10 young obese (YO), 11 old lean (OL), and 11 old obese (OO) Zucker rats were investigated at 4 and 14 months old. The cardiac characteristics, apoptotic, hypertrophic, and fibros
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48

Au, Sin Tung. "The Effects of 17B-estradiol on Cognition." Thesis, 2012. http://hdl.handle.net/1807/33327.

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A bilateral salpingo oophorectomy (BSO), removal of the ovaries, is recommended for carriers of BRCA1/2 mutations to reduce cancer risks. However, BSO induces surgical menopause, and is associated with an increased risk of dementia (Rocca et al., 2007a) and Parkinsonism (Rocca et al, 2007b). This study investigated the cognitive outcomes of BSO one to ten years post-surgically. The present dataset (n=37) revealed there was a significant difference between the BSO group and their age matched cohort on the Logical Memory task assessing verbal, episodic memory. Levels of E1G (estrogen metabolite)
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Medková, Jaroslava. "Optimalizace stanovení endokrinních disruptorů v čistírenských kalech a aplikace metody v reálných vzorcích." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-307047.

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Hormonaly active compounds in wastewaters represent nowdays a serious problem. Proceses currently used in watewater treatment plants (WWTP) are unefficient in removing these compounds from contaminated wastewaters. The compounds are supposed to sorb onto solid sludge elements and sediments. In this work seven endocrine disruptors were detected in the sludge samples from WWTPs. A new sensitive method for detection of seven selected endocrine disruptors (4-nonylphenol, bisphenol A, estriol, 17β-estradiol, estrone, 17α- ethynylestradiol, irgasan) was developed. The method is based on accelerated
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Cheng, Hui-Wen, та 鄭惠文. "Development of analyzing estrone, 17β-estradiol, 17?ethinyl estradiol and estriol in water using solid-phase extraction and LC/MS/MS". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/71317230607520519115.

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碩士<br>國立臺灣大學<br>環境衛生研究所<br>92<br>Endocrine disrupting compounds (EDCs) have brought attention because their potential ecological and health effects. We analyzed Estrone, estriol, 17β-estradiol, and 17?ethinyl estradiol, which belong to this group of chemicals. We used solid-phase extraction and LC/MS/MS techniques to analyze the four steroids. Without adjusting pH of water sample, we found J.T. Baker PolarPlus C18 disks provided better retention and faster flow rates than traditional C18 adsorbents. After washing with 40% methanol/60% water (in order to remove polar co-extracts), analytes were
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