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Journal articles on the topic 'Ethical Issues of Gene Editing'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Doudna, Jennifer. "CRISPR and Gene Editing: Ethical and Scientific Perspectives." International Journal of Innovative Computer Science and IT Research 1, no. 01 (2025): 1–5. https://doi.org/10.63665/ijicsitr.v1i01.05.

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CRISPR-Cas9 has emerged as one of the most transformative tools in genetic engineering, enabling scientists to perform precise, efficient, and cost-effective gene modifications. This revolutionary gene-editing technology has broad applications in medicine, agriculture, and biotechnology, offering solutions to previously untreatable genetic disorders, enhancing crop resilience, and advancing synthetic biology. In medicine, CRISPR is being explored for treating hereditary diseases, cancer, and infectious diseases, while in agriculture, it is being used to develop disease-resistant crops, improve

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2

Bailey, Jarrod. "CRISPR-Mediated Gene Editing: Scientific and Ethical Issues." Trends in Biotechnology 37, no. 9 (2019): 920–21. http://dx.doi.org/10.1016/j.tibtech.2019.05.002.

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Palazzani, Laura. "Gene-editing: ethical and legal challenges." Medicina e Morale 72, no. 1 (2023): 49–57. http://dx.doi.org/10.4081/mem.2023.1227.

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The article focuses on gene-editing as a technology with unprecedented perspectives but also emerging ethical questions. The main general question is the urgency of the progress of science on the one hand and the responsibility of scientists with respect to the value of human life and fundamental human rights on the other. The article analyses the ethical discussion, considering the kind of intervention (on somatic line or on germ line) and purpose (preventivetherapeutic or enhancement), in the context of pluralistic debate. The author discusses the arguments in favor of the libertarians and u

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Cwik, Bryan. "Intergenerational monitoring in clinical trials of germline gene editing." Journal of Medical Ethics 46, no. 3 (2019): 183–87. http://dx.doi.org/10.1136/medethics-2019-105620.

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Design of clinical trials for germline gene editing stretches current accepted standards for human subjects research. Among the challenges involved is a set of issues concerning intergenerational monitoring—long-term follow-up study of subjects and their descendants. Because changes made at the germline would be heritable, germline gene editing could have adverse effects on individuals’ health that can be passed on to future generations. Determining whether germline gene editing is safe and effective for clinical use thus may require intergenerational monitoring. The aim of this paper is to id

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Wu, Yirui. "The Development of Gene Editing Technology and Controversial Issues: A Discussion." Highlights in Science, Engineering and Technology 91 (April 15, 2024): 123–30. http://dx.doi.org/10.54097/6gj0tk11.

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The fields of genetics and biomedicine stand to benefit greatly from the innovative technique known as gene editing technology, especially with the potential uses of CRISPR-Cas9.the creation of crops resistant to disease, the treatment of genetic illnesses, and the advancement of biomedical research in fields like sickle-cell anemia and rice gene editing are all made possible by CRISPR-Cas9's capacity to precisely pinpoint and edit specific genes. Despite being beneficial to humanity, the quick development of human gene editing technology has also brought up ethical, legal, societal, and techn

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Ormond, Kelly E., Yvonne Bombard, Vence L. Bonham, et al. "The clinical application of gene editing: ethical and social issues." Personalized Medicine 16, no. 4 (2019): 337–50. http://dx.doi.org/10.2217/pme-2018-0155.

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7

Huang, Huaping. "Methodological exploration of using gene editing technology to study gene function and disease mechanism." Transactions on Materials, Biotechnology and Life Sciences 7 (December 24, 2024): 433–39. https://doi.org/10.62051/xtck5y05.

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This paper discusses the application of gene editing technology, especially CRISPR-Cas9 system, in the study of gene function and disease mechanism. By modifying the genome sequence at a fixed point, gene editing technology uses specific nucleases to induce double strand breaks, trigger DNA repair mechanism, and realize accurate gene modification. This paper introduces the working principle of CRISPR-Cas9 and its application in establishing gene knock-out and knock-in models, and emphasizes the importance of this technology in revealing gene function and molecular mechanism of diseases. Howeve

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Gloria, Nataly Pérez Serrano, and Jeraldine Gonzalez Barajas Alejandra. "Gene Editing in Cancer Therapy." International Journal Of Medical Science And Clinical Research Studies 02, no. 10 (2022): 1120–22. https://doi.org/10.5281/zenodo.7248771.

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The site-specific modification of an existing gene is known as gene editing. A section of DNA must be cut with an endonuclease (such as the CRISPR-Cas9 system) before the two severed ends are brought together, frequently with a new or improved sequence inserted between them. Somatic cell gene editing can be helpful in a variety of clinical contexts, and some preliminary preclinical and clinical trials have been carried out. Extremely high levels of precision are required for DNA recognition, excision, and repair; issues with publishing integrity must be resolved. Germline editing utilizing egg

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9

Jennifer, Doudna. "CRISPR and Gene Editing: Ethical and Scientific Perspectives." International Journal of Innovative Computer Science and IT Research 01, no. 01 (2025): 29–33. https://doi.org/10.5281/zenodo.15152043.

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CRISPR-Cas9 has emerged as one of the most transformative tools in genetic engineering, enabling scientists to perform precise, efficient, and cost-effective gene modifications. This revolutionary gene-editing technology has broad applications in medicine, agriculture, and biotechnology, offering solutions to previously untreatable genetic disorders, enhancing crop resilience, and advancing synthetic biology. In medicine, CRISPR is being explored for treating hereditary diseases, cancer, and infectious diseases, while in agriculture, it is being used to develop di

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10

Vaishnavi, Bhad Gaurav Bhalerao Rani Deokar*. "CRISPR-CAS 9 In Gene Editing: Innovations, Applications and Ethical Challenges." International Journal of Scientific Research and Technology 1, no. 11 (2024): 59–71. https://doi.org/10.5281/zenodo.14161891.

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CRISPR-Cas9 has emerged as a revolutionary tool in gene editing, enabling precise alterations in the DNA sequence with unprecedented accuracy and efficiency. This technology leverages the natural defense mechanism of bacteria against viruses, allowing researchers to target specific genes for modification, deletion, or insertion. The potential applications of CRISPR-Cas9 are vast, ranging from therapeutic interventions for genetic disorders, cancer treatment, and viral infections to advancements in agriculture and biotechnology. Despite its promise, CRISPR-Cas9 raises significant ethical concer

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11

Tabassum Javed, Gulseema, Iqra Alitaf, and Iqra Shareef. "Assessing Public Awareness and Ethical Perceptions of CRISPR-Cas9 Gene Editing Technology." Physical Education, Health and Social Sciences 3, no. 3 (2025): 95–100. https://doi.org/10.63163/jpehss.v3i3.517.

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Background: CRISPR-Cas9 represents an innovative gene editing technology that has the power to revolutionize medicine, agriculture, and biotechnology. Nevertheless, public understanding and ethical acceptance are paramount for its integration into society.Objective: This study explores public awareness, self-reported knowledge, and ethical attitudes towards CRISPR-Cas9, with a special emphasis on its therapeutic and enhancement-related purposes.Methods: A structured questionnaire was administered to 107 participants with a wide range of demographic backgrounds. The questionnaire asked for info

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Zhang, Di, and Reidar K. Lie. "Ethical issues in human germline gene editing: a perspective from China." Monash Bioethics Review 36, no. 1-4 (2018): 23–35. http://dx.doi.org/10.1007/s40592-018-0091-0.

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13

Udbhaw, Mishra, Kumar Piyush, Joshi Pawan, and Kumar Sanjeeva. "Genetic Editing: From Historical Foundations to Future Frontiers." International Journal of Pharmaceutical and Clinical Research 16, no. 10 (2024): 956–62. https://doi.org/10.5281/zenodo.14106623.

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Genetic editing has evolved from early methods of DNA manipulation to advanced techniques that hold transformative potential in medicine, agriculture, and environmental science. This review examines the historical development of genetic editing technologies, including recombinant DNA technology, Zinc Finger Nucleases (ZFNs), and more recent advancements such as TALENs and CRISPR-Cas9. CRISPR-Cas9 has revolutionized genetic editing because of its precision and versatility, enabling significant breakthroughs in gene therapy, crop improvement, and functional genomics. Despite its success, the fie

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14

Wang, Jingyi. "The application and development of CRISPR Cas9." Highlights in Science, Engineering and Technology 102 (July 11, 2024): 627–34. http://dx.doi.org/10.54097/ecydqr13.

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This comprehensive review paper thoroughly explores the developmental background, basic principles, application examples, and the current challenges and ethical issues associated with CRISPR-Cas9 technology, and provides an in-depth forecast and outlook on its future directions. Originating from a natural immune mechanism in bacteria, CRISPR-Cas9 technology can precisely identify and cut targeted DNA sequences to achieve gene editing. Characterized by its ease of operation, low cost, and high efficiency, it has been widely applied in biological research, medical treatment, agricultural improve

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15

NEUHAUS, CAROLYN P., and BRENDAN PARENT. "Gene Doping—in Animals? Ethical Issues at the Intersection of Animal Use, Gene Editing, and Sports Ethics." Cambridge Quarterly of Healthcare Ethics 28, no. 1 (2018): 26–39. http://dx.doi.org/10.1017/s096318011800035x.

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Abstract:Gene editors such as CRISPR could be used to create stronger, faster, or more resilient nonhuman animals. This is of keen interest to people who breed, train, race, and profit off the millions of animals used in sport that contribute billions of dollars to legal and illegal economies across the globe. People have tried for millennia to perfect sport animals; CRISPR proposes to do in one generation what might have taken decades previously. Moreover, gene editing may facilitate enhancing animals’ capacities beyond their typical limits. This paper describes the state of animal use and en

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Louwaars, Niels, and Henk Jochemsen. "An Ethical and Societal Analysis for Biotechnological Methods in Plant Breeding." Agronomy 11, no. 6 (2021): 1183. http://dx.doi.org/10.3390/agronomy11061183.

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Technological developments in plant breeding, notably cisgenesis and gene editing, require a rethinking of biotechnology policies. In addition to legal debates about the definition of genetic modification in the Cartagena Protocol and at national and supra-national levels, and debates about the safety of the resulting products for mankind and environment, discussions are ongoing in society concerning ethical and societal questions. In this paper, we analyse the main ethical issues that need to be taken into account when evaluating contemporary plant breeding techniques. After a brief descripti

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17

Wang, Boyi. "Progress and optimization of CRISPR-Cas9/12 application in CAR-T therapy." Theoretical and Natural Science 66, no. 1 (2024): 178–83. https://doi.org/10.54254/2753-8818/2024.18080.

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CAR-T therapy and CRISPR/Cas9 gene editing technology have shown great potential in cancer treatment and gene editing, respectively. Combining these two technologies can significantly improve the effect of cancer treatment. However, CAR-T therapy has problems such as complex production, toxicity and functional failure, while CRISPR/Cas9 technology faces challenges such as off-target effects. This study first reviewed the basic principles of CAR-T therapy and CRISPR/Cas9 technology and their current application status, analyzed the feasibility of applying CRISPR/Cas9 technology to CAR-T therapy

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Xu, Jiabao. "CRISPR-Cas9 as a tool for treating cystic fibrosis through gene editing." Theoretical and Natural Science 6, no. 1 (2023): 191–97. http://dx.doi.org/10.54254/2753-8818/6/20230222.

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The most common cause of mortality is Cystic Fibrosis, a fatal genetic disease. However, in recent years, there have been a growing number of papers concentrating on CRISPR-Cas9, a gene-editing tool that is being used to permanently cure this genetic disease, named by a biopharmaceutical company EditasMedicine, invested in by Bill Gates. However, before the breadth of search and study of this technology continuously expands, challenges and remaining issues should be addressed. This paper reviews the mechanisms of cystic fibrosis and discusses its technical challenges, such as efficiency, safet

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19

Zhou, Hang, Yun Wang, Li-Ping Liu, Yu-Mei Li, and Yun-Wen Zheng. "Gene Editing in Pluripotent Stem Cells and Their Derived Organoids." Stem Cells International 2021 (November 30, 2021): 1–14. http://dx.doi.org/10.1155/2021/8130828.

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With the rapid rise in gene-editing technology, pluripotent stem cells (PSCs) and their derived organoids have increasingly broader and practical applications in regenerative medicine. Gene-editing technologies, from large-scale nucleic acid endonucleases to CRISPR, have ignited a global research and development boom with significant implications in regenerative medicine. The development of regenerative medicine technologies, regardless of whether it is PSCs or gene editing, is consistently met with controversy. Are the tools for rewriting the code of life a boon to humanity or a Pandora’s box

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20

Coller, Barry S. "Ethics of Human Genome Editing." Annual Review of Medicine 70, no. 1 (2019): 289–305. http://dx.doi.org/10.1146/annurev-med-112717-094629.

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Advances in human genome editing, in particular the development of the clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 method, have led to increasing concerns about the ethics of editing the human genome. In response, the US National Academy of Sciences and the National Academy of Medicine constituted a multidisciplinary, international committee to review the current status and make recommendations. I was a member of that committee, and the core of this review reflects the committee's conclusions. The committee's report, issued in February 2017, recommends the application of

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Yüksel, Fatma. "Comprehensive Exploration of CRISPR and Gene Editing Technologies: Applications, Ethical Considerations, and Future Implications in Genetic Research." Next Frontier For Life Sciences and AI 8, no. 1 (2024): 69. http://dx.doi.org/10.62802/3nwhcj06.

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CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and other gene-editing technologies have revolutionized genetic research by enabling precise, targeted modifications of DNA sequences. This paper provides a comprehensive exploration of CRISPR technology, detailing its development, mechanism of action, and versatility in diverse applications. From advancements in medicine, including therapeutic interventions for genetic disorders, to innovations in agriculture aimed at enhancing crop resilience and yield, CRISPR's transformative potential is vast. However, the rapid evolution o

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22

Jamil, Arif, Shamima Parvin Lasker, and Ahmed Ragib Chowdhury. "Gene Modification in Non-Human Animal for Developing Human Compatible Organs: Ethical, Legal, Clinical and Societal Issues." Bangladesh Journal of Bioethics 15, no. 2 (2023): 13–18. http://dx.doi.org/10.62865/bjbio.v14i2.57.

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CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) as a gene editing tool is a precise and promising technology. By CRISPR technology, human gene can be introduced into the animal gene pool to develop chimera for human like cells/tissue. However, the long term effects of gene editing in human is unknown. After revisiting the state-of-the-art publications in this discipline, it appears that the possibility of development to full-term chimeric/non-human animal by CRISPR technic for xenotransplantation is a future reality. Concern over the safety and ethical issues of gene modific

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Kohn, Donald B., Matthew H. Porteus, and Andrew M. Scharenberg. "Ethical and regulatory aspects of genome editing." Blood 127, no. 21 (2016): 2553–60. http://dx.doi.org/10.1182/blood-2016-01-678136.

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Abstract Gene editing is a rapidly developing area of biotechnology in which the nucleotide sequence of the genome of living cells is precisely changed. The use of genome-editing technologies to modify various types of blood cells, including hematopoietic stem cells, has emerged as an important field of therapeutic development for hematopoietic disease. Although these technologies offer the potential for generation of transformative therapies for patients suffering from myriad disorders of hematopoiesis, their application for therapeutic modification of primary human cells is still in its infa

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Fernando, Kalani, Duminda De Silva, and Asanka Ekanayake. "Regulatory Frameworks for Human Gene Editing: A Systematic Literature Review." International Journal of Law and Policy 3, no. 6 (2025): 21–49. https://doi.org/10.59022/ijlp.333.

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Human gene editing technologies, especially CRISPR-Cas9, have advanced rapidly, raising complex regulatory, ethical, and scientific issues. This study reviews 47 peer-reviewed articles published between 2015 and 2025, following PRISMA 2020 guidelines. The analysis reveals major empirical, theoretical, methodological, and practical gaps in governance. It notes a lack of global harmonisation, weak ethical oversight, and inconsistent national policies that obstruct responsible innovation. Developing countries often lack enforceable guidelines, while developed nations use varied regulatory framewo

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Savulescu, Julian, and Marcos Alonso. "Is Gene Editing Harmless? Two Arguments for Gene Editing." American Journal of Bioethics 22, no. 9 (2022): 23–28. http://dx.doi.org/10.1080/15265161.2022.2105432.

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Mulvihill, John J., Benjamin Capps, Yann Joly, Tamra Lysaght, Hub A. E. Zwart, and Ruth Chadwick. "Ethical issues of CRISPR technology and gene editing through the lens of solidarity." British Medical Bulletin 122, no. 1 (2017): 17–29. http://dx.doi.org/10.1093/bmb/ldx002.

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Huadong Yang. "Application and Prospect of CRISPR-Cas9 Gene Editing Technology in Agricultural Breeding." Life Studies 1, no. 1 (2025): 56–69. https://doi.org/10.71204/ee86j863.

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Since its inception in 2012, the gene editing technology CRISPR-Cas9 has rapidly become a revolutionary tool in the field of gene editing due to its high efficiency, specificity, and ease of operation. In the field of agricultural breeding, the application of CRISPR-Cas9 technology provides unprecedented opportunities for improving crop yield, enhancing stress resistance, and enhancing quality. This study systematically elucidates the basic principles of CRISPR-Cas9 technology, including its composition, functions, and the implementation process of gene editing, and deeply analyzes the advanta

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Ahmad, Ashfaq. "CRISPR-Cas-Based Epigenome Editing as a Novel Therapeutic Strategy for Metabolic Disorders: Targeting Gene Expression Patterns in Specific Tissues to Treat Diabetes and Obesity." Diabetes & Obesity International Journal 8, no. 4 (2023): 1–18. http://dx.doi.org/10.23880/doij-16000278.

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Metabolic disorders such as diabetes and obesity are major public health concerns that affect millions of people worldwide. Epigenetic modifications have been implicated in the development and progression of these disorders, making them attractive targets for therapeutic intervention. The emergence of Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPRCas-based) epigenome editing technology has revolutionized the field of gene editing and holds great promise for the treatment of metabolic disorders. However, there are still significant challenges and ethical concerns that must be

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Zhou, Yize. "A Systematic Review of Gene Editing Therapy for Acquired Immunodeficiency Syndrome." Highlights in Science, Engineering and Technology 74 (December 29, 2023): 763–68. http://dx.doi.org/10.54097/3pkgev27.

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Acquired immunodeficiency syndrome (AIDS) is a deadly immunological disease that affects the immune system and becomes more common in recent years, which is brought on by the inflection of human immunodeficiency (HIV). The treatment of AIDS has always been a major challenge for the medical community to overcome because the existing treatment methods are not universal. At present, the scientific community is focusing on gene editing therapy, and the feasible tools are zinc finger nucleases (ZFNs), transcription activator-like nucleases (TALENs), and clustered regularly interspaced short palindr

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Dr.A.Shaji, George, George A.S.Hovan, Himika Devi Dr.Salam, and Shahul Aakifa. "Your Future Kids Might Be Genetically Engineered: Implications, Possibilities, and Ethical Considerations." Partners Universal Innovative Research Publication (PUIRP) 03, no. 02 (2025): 1–9. https://doi.org/10.5281/zenodo.15249246.

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Recent advances in gene editing and reproductive technologies may enable prospective parents to genetically modify embryos before implantation, raising the possibility of "designer babies." This could eliminate inherited diseases, select traits like intelligence and athleticism, and enable same-sex couples to biologically conceive. However, it also poses ethical issues around inequality, regulation, safety concerns from manipulating the human genome, and the overall societal impacts of steering human evolution. This paper provides an overview of the technologies involved, potential medical ben

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Refolo, Pietro, Vincenzo L. Pascali, and Antonio G. Spagnolo. "Editing genetico: nuova questione bioetica? / Gene editing: a new issue for Bioethics?" Medicina e Morale 66, no. 3 (2017): 291–304. http://dx.doi.org/10.4081/mem.2017.493.

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Modificazioni controllate nel genoma sono possibili, tramite svariate tecniche, sin dagli anni ’70. Nucleasi a dito di zinco, nucleasi TALE, ma soprattutto CRISPR-Cas9 sono tecniche di editing genetico che hanno reso più semplice effettuarle. Il sistema CRISPR-Cas9, in particolare, si sta dimostrando estremamente vantaggioso in termini di accessibilità, efficienza e versatilità. Gli obiettivi del presente contributo consistono nel: 1. ricostruire i “fatti” salienti che hanno determinato l’emergere del topic dell’“editing genetico”; 2. provare a dar risposta a un primo fondamentale interrogativ

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Spartalis, Michael, Eleftherios Spartalis, and Gerasimos Siasos. "Inherited arrhythmias and gene therapy: Are there any ethical considerations to take into account?" World Journal of Cardiology 15, no. 12 (2023): 623–26. http://dx.doi.org/10.4330/wjc.v15.i12.623.

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Interventional electrophysiology represents a relatively recent subspecialty within the field of cardiology. In the past half-century, there has been significant advancement in the development and implementation of innovative ablation treatments and approaches. However, the treatment of arrhythmias continues to be inadequate. Several arrhythmias, such as ventricular tachycardia and atrial fibrillation, pose significant challenges in terms of therapeutic efficacy, whether through interventional procedures or the administration of antiarrhythmic drugs. Cardiologists are engaged in ongoing resear

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Bhandari, Sarada, and Lokendra Nath Yogi. "A REVIEW ON RECENT ADVANCES IN ANIMAL BIOTECHNOLOGY." Science Heritage Journal 7, no. 2 (2023): 79–82. http://dx.doi.org/10.26480/gws.02.2023.79.82.

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Animal biotechnology represents a cutting-edge field that has revolutionized our interactions with the animal kingdom. Recent advancements encompass various domains, including genetic editing techniques like CRISPR-Cas9, which allow precise genetic modifications for improved animal health and product quality. Cloning and reproductive technologies offer opportunities to preserve rare genetic traits and enhance livestock production, albeit accompanied by ethical and genetic diversity challenges. Transgenic animals, engineered with foreign genes, serve purposes from increased productivity to dise

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Anupama, M. "CRISPR-Cas9 Gene Editing: Precision Technology with Transformative Potential and Ethical Implications." Journal of food and biotechnology 6, no. 1 (2025): 22–26. https://doi.org/10.51470/fab.2025.6.1.22.

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The CRISPR-Cas9 technology has completely changed the fields of molecular biology and biotechnology. It provides a precise and easy way to alter genes. This system was first found in bacteria and archaea as a part of their immune defence against viruses. In 2012, scientists Jennifer Doudna and Emmanuelle Charpentier took this system and modified it so it could work in eukaryotic cells, turning it into a powerful tool for editing genomes. The process uses the Cas9 enzyme, which is directed by a specially designed single guide RNA) to find a matching DNA sequence. When it gets to that spot, it c

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Molochaeva, L. G., and N. M. Mirzoeva. "Biotechnology and advanced medical technologies." BIO Web of Conferences 82 (2024): 02038. http://dx.doi.org/10.1051/bioconf/20248202038.

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This study considers a complex synergy of biotechnologies and advanced medical technologies. The growing convergence of their positions is clearly shown in shaping the transformational era in healthcare. The study exposes developments ranging from precision gene editing to organ bioprinting and the rise of personalized medicine through extensive literature reviews, case study analyses, and expert interviews. Notwithstanding that these advancements promise unprecedented therapeutic and diagnostic capabilities, they also present challenges. Technological barriers in association with profound eth

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Farheen Taj Shaik and Sravani Yarra. "Beyond the hype: A critical review of crispr-Cas9 gene editing therapies." International Journal of Science and Research Archive 14, no. 2 (2025): 1525–39. https://doi.org/10.30574/ijsra.2025.14.2.0492.

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CRISPR-Cas9 gene editing has emerged as a revolutionary tool with the potential to reshape medicine. However, critical evaluation is necessary to navigate beyond the hype and assess its true therapeutic potential. This review examines the background, promise, and challenges of CRISPR-Cas9 therapies. It explores its simplicity, efficiency, and transformative impact on biological research. While acknowledging the excitement, the review emphasizes the need to address ethical concerns, off-target effects, delivery issues, and long-term safety. By critically appraising the efficacy, safety, and eth

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Iqbal, Gowhar, Nahida Quyoom, Lukram Sushil Singh, et al. "Genome Editing Technology in Fishes." Current Journal of Applied Science and Technology 42, no. 23 (2023): 20–26. http://dx.doi.org/10.9734/cjast/2023/v42i234170.

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Genome editing and silencing techniques can transform the biology that we understand, diseases affecting fish and other aquatic animals. Gene editing is now being tested in aquaculture, reproduction control, sterility, and disease resistance aspects. More money must be invested in innovative technology to solve these issues in this industry. So gene silencing and genomic DNA editing have the potential significant impact on aquatic animal treatment in the future. Genome editing in fish is an interested part of research that has the potential to revolutionize aquaculture and aid in the understan

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Selvam, Divyabharathi, and Karthikeyan Vasudevan. "CRISPR IN ORAL ONCOLOGY: BRIDGING PRECISION MEDICINE AND ETHICAL CHALLENGES." International Journal of Advanced Research 12, no. 09 (2024): 118–21. http://dx.doi.org/10.21474/ijar01/19434.

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CRISPR technology has revolutionized gene editing, with implications across various fields, including oncology. In oral cancer research, CRISPR offers unprecedented precision in targeting and modifying cancer-associated genes. However, despite its promise, significant challenges prevent its widespread clinical use. This Perspective article will focus on the critical challenges of CRISPR implementation in oral oncology, such as the technical limitations, ethical concerns, and the need for innovative delivery mechanisms. We propose that addressing these issues could pave the way for more effecti

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Beriain, Iñigo de Miguel, Emilio Armaza Armaza, and Aliuska Duardo Sánchez. "Human germline editing is not prohibited by the Oviedo Convention: An argument." Medical Law International 19, no. 2-3 (2019): 226–32. http://dx.doi.org/10.1177/0968533219862590.

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Human germline gene editing has ignited wide-ranging debates on the ethical and legal issues involved. The text of the Oviedo Convention is particularly relevant here, as it remains the only international legally binding instrument on the protection of human rights in the biomedical field which considers human genome modification. However, it is often misinterpreted. Indeed, most of the academic literature assumes that Article 13 forbids germline gene editing. This article seeks to demonstrate that this belief is mistaken. To this purpose, it develops a general analysis of the Convention, its

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De Araujo, Marcelo. "Editing the Genome of Human Being." Journal of Ethics and Emerging Technologies 27, no. 1 (2017): 24–42. http://dx.doi.org/10.55613/jeet.v27i1.65.

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In 2015 a team of scientists used a new gene-editing technique called CRISPR-Cas9 to edit the genome of 86 non-viable human embryos. The experiment sparked a global debate on the ethics of gene editing. In this paper, I first review the key ethical issues that have been addressed in this debate. Although there is an emerging consensus now that research on the editing of human somatic cells for therapeutic purpose should be pursued further, the prospect of using gene-editing techniques for the purpose of human enhancement has been met with strong criticism. The main thesis that I defend in this

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Motta, Benedetta M., Peter P. Pramstaller, Andrew A. Hicks, and Alessandra Rossini. "The Impact of CRISPR/Cas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches." Stem Cells International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/8960236.

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Genome-editing technology has emerged as a powerful method that enables the generation of genetically modified cells and organisms necessary to elucidate gene function and mechanisms of human diseases. The clustered regularly interspaced short palindromic repeats- (CRISPR-) associated 9 (Cas9) system has rapidly become one of the most popular approaches for genome editing in basic biomedical research over recent years because of its simplicity and adaptability. CRISPR/Cas9 genome editing has been used to correct DNA mutations ranging from a single base pair to large deletions in both in vitro

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Eski, Nursel, Huda Asif, Jacqueline Crespo, and Yakup Bayar. "Exploring the Role of CRISPR-Cas9 in Genetic Engineering: Advancements, Applications, and Ethical Issues." Proceedings of London International Conferences, no. 11 (October 12, 2024): 158–70. http://dx.doi.org/10.31039/plic.2024.11.260.

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Since its discovery in 1987, the emerging genome-modification technology CRISPR-Cas9 has augmented the ever-evolving field of genetic engineering through its advancements in precision and accuracy to simplify efficient genome alteration. This paper introduces the history of CRISPR-Cas9 and explores its underlying mechanisms and advancements. Significant technological advancements have enhanced the precision and efficiency of CRISPR-Cas9 in genetic engineering. Innovations like base and prime editors minimize the unintended off-target effects, improving the accuracy of gene editing. The develop

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Laddaga, Filomena Emanuela, Bruna Daraia, Pamela Pinto, et al. "Mechanisms of Action of Ready-to-Use Therapies in Hematologic Malignancies: From Clinical Impact to Future Directions." OBM Transplantation 09, no. 02 (2025): 1–12. https://doi.org/10.21926/obm.transplant.2502250.

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Off-the-shelf cellular therapies, utilizing allogeneic T cells derived from healthy donors, represent a promising alternative to autologous chimeric antigen receptor T-cell (CAR-T) therapies for the treatment of hematological malignancies such as leukemias and lymphomas. Unlike autologous approaches, which require the patient’s own cell collection, modification, and expansion, off-the-shelf therapies can be prepared in advance, substantially reducing treatment timelines, decreasing costs, and improving global accessibility. Recent technological advancements, including gene-editing techniques s

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Sahoo, Lipikant, Deepali Mohapatra, Sunandan Swain, S. Kanaka, and Vaishali Sinha. "CRISPR-Cas9 Technology and its Impact on Plant Biology." Journal of Plant Biota 2, no. 2 (2023): 1–4. http://dx.doi.org/10.51470/jpb.2023.02.02.01.

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CRISPR-Cas9 technology has emerged as a powerful tool for precise genome editing, revolutionizing various fields including plant biology. This abstract explores the impact of CRISPR-Cas9 on plant biology, focusing on its applications, challenges, and prospects. The versatility of CRISPR-Cas9 enables targeted modifications in plant genomes, facilitating crop improvement, nutritional enhancement, environmental adaptation, and bioremediation. By editing specific genes associated with desired traits, researchers can develop crops with increased yields, resistance to pests and diseases, and enhance

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Mollaki, Vasiliki. "Ethical Challenges in Organoid Use." BioTech 10, no. 3 (2021): 12. http://dx.doi.org/10.3390/biotech10030012.

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Organoids hold great promises for numerous applications in biomedicine and biotechnology. Despite its potential in science, organoid technology poses complex ethical challenges that may hinder any future benefits for patients and society. This study aims to analyze the multifaceted ethical issues raised by organoids and recommend measures that must be taken at various levels to ensure the ethical use and application of this technology. Organoid technology raises several serious ethics issues related to the source of stem cells for organoid creation, informed consent and privacy of cell donors,

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Superson, Maciej, Katarzyna Szmyt, Klaudia Wilk-Trytko, et al. "Applications of gene modification technologies in the treatment of inherited diseases." Journal of Education, Health and Sport 66 (April 18, 2024): 50073. http://dx.doi.org/10.12775/jehs.2024.66.002.

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Introduction and Purpose: In last years gene modification technologies such as CRISPR/Cas9 has had a revolutionary impact on the treatment of inherited diseases. Technologies developed from bacterial defense mechanisms, has become a basic tools in scientific research and medical therapies. In our article we provided an overview of applications of gene modifications technologies, directly focusing on CRISPR/Cas9, in genetic disease treatment.  State of Knowledge: New applications of CRISPR/Cas9 are still being explored. Treating inherited diseases such as cystic fibrosis, Duchenne m

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Shi, Chongwei. "Application of Genetic Research Techniques in Myopia Research." International Journal of Computer Science and Information Technology 4, no. 2 (2024): 94–100. http://dx.doi.org/10.62051/ijcsit.v4n2.14.

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The rapid development of genetic research techniques has provided new perspectives and tools for the study of myopia. This paper reviews several key genetic technologies, including genome sequencing, gene editing technologies, genetic association studies, and epigenetic technologies, and explores their applications in myopia research. Through genome sequencing, researchers can identify genetic variations associated with myopia; gene editing technologies offer powerful tools to explore gene functions and their impact on myopia; genetic association studies help reveal genes and genetic markers r

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Ewuoso, Cornelius. "Germline Gene Editing Applications and the Afro-communitarian Ubuntu Philosophy." Filosofia Theoretica: Journal of African Philosophy, Culture and Religions 12, no. 1 (2023): 1–12. http://dx.doi.org/10.4314/ft.v12i1.1.

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Germline gene editing has many applications or uses. This article focuses on specific applications. Specifically, the article draws on a moral norm arising from the thinking about the value of communal relationships in the Afro-communitarian ubuntu philosophy to interrogate key issues that specific applications of germline gene editing – for xeno-transplantation, agriculture and wildlife – raise. The article contends that the application of germline gene editing in these areas is justified to the extent that they foster the capacity to relate with others and to be communed with by others. The

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Schneider, Manuel, Alessandro Blasimme, and Effy Vayena. "Understanding Global Challenges of Rapidly Developing Technologies: Digital Methods for Empirical Bioethics." Studia Universitatis Babeş-Bolyai Bioethica 66, Special Issue (2021): 158. http://dx.doi.org/10.24193/subbbioethica.2021.spiss.106.

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"Since the first successful application of the gene editing method based on the CRISPR/Cas-system, the technology has demonstrated great potential but also sparked a series of ethical concerns. Some of the issues are already known from earlier gene editing debates. However, the possibility of CRISPR to target genes with high accuracy and the easy application that allows a biohacker to experiment with a simple toolkit ordered online have introduced new ethical challenges. Further, thanks to preprint servers such as bioRxiv, biomedical research results are more and more accessible with little de

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Mohammed J. Kadhim. "The Role of CRISPR-Cas9 in Gene Editing." OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan 3, no. 2 (2025): 90–100. https://doi.org/10.61132/obat.v3i2.1108.

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The CRISPR-Cas9 technique is a contemporary technology that has transformed the process of genetic modification, allowing scientists to target genomes in living organisms with precision and simplicity. Numerous practical applications of significant importance, including the introduction of new genes into living cells, are facilitated by the CRISPR-Cas9 system's advanced level of gene targeting, precision, and simplicity of use. An enigmatic process involving repeated DNA sequences in E. coli initiated the emergence of this CRISPR-Cas9 mechanism. After observing this phenomenon in bacteria, sci

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