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Journal articles on the topic 'Ethoxy derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Hoai, N. T., Tran Thi Yen Ngoc, Nguyen Dang Nam та ін. "Effect oF β-Alanine on The Preparation of 4-Ethoxy-Cinnamic Acid". Open Materials Science Journal 12, № 1 (2018): 58–67. http://dx.doi.org/10.2174/1874088x01812010058.

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Objective:Cinnamic acid and its derivatives have a numerous potential applications in many different fields such as pharmacy, organic “building blocks”, and corrosion inhibitors.Method:It is well-known that Verley-Doebner modification is a high efficient method for the preparation of cinnamic acid derivaties, especially with the compounds containing electron-donating subtituents at para position in aromatic ring. In this paper, 4-ethoxy-cinnamic acid was synthesized according to Verley-Doebner reaction with the use of pyrine acting as catalyst and solvent. The effect of the β-alanine concentra

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2

Göksel, Meltem, Mahmut Durmuş, and Devrim Atilla. "A comparative study on photophysical and photochemical properties of zinc phthalocyanines with different molecular symmetries." Journal of Porphyrins and Phthalocyanines 16, no. 07n08 (2012): 895–906. http://dx.doi.org/10.1142/s1088424612500964.

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The five possible non-peripherally substituted zinc(II) phthalocyanines with different molecular symmetries (Pc1–Pc5) were synthesized from statistical condensation of the phthalonitrile derivatives (A and B). 2-[2-(2-ethoxyethoxy)ethoxy]-1-[2-((2-ethoxyethoxy)-ethoxy)ethoxymethyl]ethyloxy and 2′-[(tert-butoxycarbonyl)amino]ethoxy groups were used as substituents. The structures of the new compounds were characterized using elemental analysis and spectroscopic data including IR, 1H and 13C NMR, electronic absorption and mass spectra. The photophysical and photochemical properties of these new

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3

Kang, Hyo Sim, Sun Wha Oh, and Young Soo Kang. "Comparison of Optical Properties of Pyrazoline Derivative Nanoparticles." Solid State Phenomena 119 (January 2007): 39–42. http://dx.doi.org/10.4028/www.scientific.net/ssp.119.39.

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We prepared various pyrazoline derivatives which possess dimethylamino-, ethoxy-, isopropyl-phenyl ring at the 5-position of pyrazoline. The nanoparticles of pyrazoline derivative ranging from tens to hundreds of nanometers by the reprecipitation method have been successfully prepared and their optical size-dependent properties have been investigated with UV-vis, fluorescence spectroscopy, DLS (Dynamic Light Scattering) and SEM. The size-dependent optical properties of pyrazoline organic nanoparticles have been observed in the order of dimethylamino- > ethoxy- > isopropyl- in electro-don

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4

Yu-Xiu, Liu, Cui Ming-Bo, Zhao Qi-Qi, Wang Qing-Min, Liu Ying, and Huang Run-Qiu. "Reduction of Pyrimidine Derivatives by LiAlH4." Journal of Chemical Research 2007, no. 8 (2007): 490–93. http://dx.doi.org/10.3184/030823407x240872.

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The reduction of ethyl 2-methylthio-(or 2-ethoxy)pyrimidine-5-carboxylate by LiAlH4 afforded ethyl 2-methylthio-(or 2-ethoxy)-1,6-dihydropyrimidine-5-carboxylate as the main product. Similarly, the reduction of 2-methylthio-(or 2-methoxy)pyrimidine-5-carboxamide by LiAlH4 gave 2-methylthio-(or 2-methoxy)-1,6-dihydropyrimidine-5-carbonitrile as main product.

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5

Xiao, Pan-Lei, Xiu-Ying Song, Xin-Ting Xiong, Da-Yong Peng, and Xu-Liang Nie. "Synthesis, Crystal Structure, Spectral Characterization and Antifungal Activity of Novel Phenolic Acid Triazole Derivatives." Molecules 28, no. 19 (2023): 6970. http://dx.doi.org/10.3390/molecules28196970.

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At present, phenolic acid derivatives and triazole derivatives have a good antifungal effect, which has attracted widespread attention. A series of novel phenolic acid triazole derivatives were synthesized, and their structures were characterized by IR, MS, NMR, and X-ray crystal diffraction. Compound methyl 4-(2-bromoethoxy)benzoate, methyl 4-(2-(1H-1,2,4-triazol-1-yl) ethoxy)benzoate, 4-(2-(1H-1,2,4-triazol-1-yl)ethoxy)benzoic acid and 4-(2-(1H-1,2,4-triazol-1-yl) ethoxy)-3-methoxybenzoic acid crystallize in the monoclinic system with space group P21/n, the monoclinic system with space group

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6

Gürsoy Kol, Özlem, Sevda Manap, Murat Beytur, Fevzi Aytemiz, Muzaffer Alkan, and Haydar Yüksek. "Antibacterial and antioxidant activities of novel 2-ethoxy- 4-[(4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]- phenyl 3-methoxybenzoate derivatives." Journal of Research in Pharmacy 29, no. 2 (2024): 692–704. https://doi.org/10.12991/jrespharm.1664907.

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In the present study, 3-alkyl/aryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) reacted with 3-ethoxy-4- (3-methoxybenzoxy)-benzaldehyde (2) to obtain the corresponding nine new 2-ethoxy-4-[(3-alkyl/aryl-4,5-dihydro-1H- 1,2,4-triazol-5-one-4-yl)azomethine]-phenyl 3-methoxybenzoates (3). The compounds 3 were also treated with 4- piperidinecarboxamide in the presence of formaldehyde according to the Mannich reaction to synthesize 2-ethoxy-4-{[3- alkyl/aryl-1-(4-piperidinecarboxamide-1-yl-methyl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl]-azomethine}-phenyl 3- methoxy-benzoates (4). The structur

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7

Çiçek, Baki, Merve Çağlı, Remziye Tülek, and Ali Teke. "Synthesis and optical characterization of bipod carbazole derivatives." Heterocyclic Communications 26, no. 1 (2020): 148–56. http://dx.doi.org/10.1515/hc-2020-0111.

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AbstractIn this study, some new biscarbazole derivatives were synthesized for the purpose of being used in OLED technologies and related areas. The following compounds: {1,2-bis(2-(3,6-diphenyl-9H-carbazole-9-yl) ethoxy)ethane (C-1), bis[2-(2-(3,6- diphenyl-9H-carbazole-9-yl) ethoxy)etyl]ether (C-2), bis[2-(2-(3,6-di(naphthalene-1-yl)-9H-carbazol-9-yl)ethoxy)etyl]ether (C-3) and bis [2-(2-(3,6-di(naphthalene-2-yl)-9H-carbazol-9-yl)ethoxy) ethyl]ether (C-4) were synthesized by Suzuki-Miyaura Cross Coupling reactions. The structural properties of the synthesized compounds were characterized by F

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8

Cai, Xiao-hua, and Bing Xie. "Synthesis and insulin-sensitizing activity of (S)-2-ethoxy-3-phenylpropanoic acid derivatives." Canadian Journal of Chemistry 84, no. 9 (2006): 1106–9. http://dx.doi.org/10.1139/v06-145.

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A series of (S)-2-ethoxy-3-phenylpropanoic acid derivatives were synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 1b (EC30 = 9.43 × 10–3 µmol/L), 1d (EC30 = 7.45 × 10–3 µmol/L), 1e (EC30 = 6.22 × 10–3 µmol/L), and 1f (EC30 = 7.76 × 10–3 µmol/L) exhibited more potent insulin-sensitizing activity than rosiglitazone (EC30 = 2.06 × 10–2 µmol/L).Key words: (S)-2-ethoxy-3-phenylpropanoic acid derivatives, type 2 diabetes, insulin-sensitizing agents.

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9

Raad, H. Turkey, A. Razzak Mahmood kubba Ammar, A. Fadhil Ammar, and N. AlShawi 3. Nada. "Synthesis and Anti-Inflammatory Activity of Some -5-Ethoxy-2- Mercapto Benzimidazole Derivatives." International Journal of Current Pharmaceutical Review and Research 8, no. 1 (2017): 24–27. https://doi.org/10.5281/zenodo.12678320.

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This article includes a description of new series of 5-ethoxy-2-mercapto benzimidazole derivatives, synthesized andevaluated for the anti-inflammatory activity; the synthesis involved the reaction of the parent nucleus (5-ethoxy-2-mercapto benzimidazole) with different p-phenacyl bromide substituents. All the newly synthesized compounds werescreened for their anti-inflammatory activity by egg albumin-induced rat hind paw edema method.

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10

Al-Rashdi, Kamelah S., Bandar A. Babgi, Ehab M. M. Ali, et al. "Tuning the anticancer properties of Pt(ii) complexes via structurally flexible N-(2-picolyl)salicylimine ligands." RSC Advances 12, no. 42 (2022): 27582–95. http://dx.doi.org/10.1039/d2ra04992a.

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11

Akbaş, Hüseyin, Ahmet Karadağ, Ali Destegül, et al. "Synthesis, and spectroscopic, thermal and dielectric properties of phosphazene based ionic liquids: OFET application and tribological behavior." New Journal of Chemistry 43, no. 5 (2019): 2098–110. http://dx.doi.org/10.1039/c8nj04948c.

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Mono(4-fluorobenzyl)cyclotriphosphazene derivatives with (dimethylamino)ethoxy (Pz1a–2a) and (dimethylamino)propoxy (Pz1b–2b) chains and their ionic liquids (PzIL1–PzIL4 and PzIL1a–PzIL4a) were synthesized.

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12

Majumdar, Krishna C., and Sintu Ganai. "Facile synthesis of benzothiadiazine 1,1-dioxides, a precursor of RSV inhibitors, by tandem amidation/intramolecular aza-Wittig reaction." Beilstein Journal of Organic Chemistry 9 (March 8, 2013): 503–9. http://dx.doi.org/10.3762/bjoc.9.54.

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Reaction of o-azidobenzenesulfonamides with ethyl carbonochloridate afforded the corresponding amide derivatives, which gave 3-ethoxy-1,2,4-benzothiadiazine 1,1-dioxides through an intramolecular aza-Wittig reaction. The reaction was found to be general through the synthesis of a number of benzothiadiazine 1,1-dioxides. Acid-catalyzed hydrolysis of 3-ethoxy-1,2,4-benzothiadiazine 1,1-dioxides furnished the 2-substituted benzothiadiazine-3-one 1,1-dioxides in good yields and high purity, which is the core moiety of RSV inhibitors.

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13

Girgis, Adel S., Marian N. Aziz, ElSayed M. Shalaby, Fahmy M. Asaad, and I. S. Ahmed Farag. "Synthesis and X-ray Studies of Novel Azaphenanthrenes." Journal of Chemical Research 42, no. 2 (2018): 90–95. http://dx.doi.org/10.3184/174751918x15183538282993.

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Two azaphenanthrenes were synthesised by a facile synthetic pathway and characterised by X-ray crystallography. Molecular packing of 4-(2,4-dichlorophenyl)-2-methoxy-5,6-dihydrobenzo[ h]quinoline-3-carbonitrile exhibits C–H…N and C–H…Cl hydrogen bonds in addition to intermolecular C–H…π, Cl…π and π…π (π-ring) stacking interactions. However, molecules of the 2-ethoxy derivative are linked into chains by one hydrogen bond of the C–H…N type and the crystal structure reveals an intermolecular C–H…π (π-ring) interaction. Computational studies by AM1, PM3, and density functional theory (DFT) techniq

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14

ASHISH, Gawai, Das SANJIB, and Yasbwant PATHAK. "NEW 7-(2-(BENZOL[d]THIAZOL-2-YLAMINO)ETHOXY)-4-METHYL-2HCHROMEN-2-0NE DERIVATIES WITH ATYPICAL ANTIPSYCHOTIC ACTIVITY." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 21, no. 21 (2013): 97–108. http://dx.doi.org/10.48141/sbjchem.v21.n21.2013.95_revista2013.pdf.

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A new series of 7-(2-(benzo[d]thiazol-2-ylamino)ethoxy)-4-methyl-2H-chromen-2-one derivatives(4a4k) was synthesized and evaluated for their D2 and 51HT2 antagonistic activity as a measure of atypical antipsychotic properly. Compounds 7-(2-(benzo[d]thiazo/-2-ylamino)ethoxy)-4-methyl-2H-chromen-2- one derivatives (4a-4k) was synthesized by refluxing 2-amino benzothiazoles substituted derivatives (3a3k) and 7-(2-Chloroethoxy)-4-melhyl-2H-chromen-2-one (2) in dry pyridine. The synthesized compounds were characterized with the help of spectral and analytical data. Most of these compounds showed dop

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15

Veeranki, Krishna Chaitanya, Jalapathi Pochampally, and Ravi Chander Maroju. "Synthesis of Novel Biaryl Fused Thiazolo[3,2-b][1,2,4]triazol-2-amines from Thiazole Amine Involving Suzuki Coupling Reaction under Microwave Irradiation." Asian Journal of Chemistry 35, no. 2 (2023): 431–34. http://dx.doi.org/10.14233/ajchem.2023.26998.

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Novel series of fused heterocycles in which amino triazole fused to biphenyl thiazole were synthesized in a multistep reaction starting from 2-aminothiazole. The amino compound with ethoxy carbonyl isothiocyanate afforded the ethyl carbamate thiomide derivative of thiazole, which further underwent intramolecular cyclization with hydroxyl amine hydrochloride in presence of DIPEA to furnish the fused thiazolotriazole amine. Haloaryl group in the fused heterocycle under Suzuki coupling condition afforded biphenyl derivatives of fused thiazolotriazole amines. All the synthesized compounds were con

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16

Pískala, Alois, Naeem B. Hanna, Jaroslav Zajíček, and Alois Čihák. "Synthesis, molecular conformation and biological activity of 6-amino-5-azacytidine." Collection of Czechoslovak Chemical Communications 54, no. 9 (1989): 2502–12. http://dx.doi.org/10.1135/cccc19892502.

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Reaction of N-ethoxycarbonylguanidine III with 2,3,5-tri-O-benzoyl-β-D-ribosyl isocyanate (II) afforded N-ethoxycarbonylamidinourea IV, which was cyclized by bis(trimethylsilyl)acetamide to the 6-ethoxy derivative VII. Ammono- and methanolysis of intermediate VII yielded 6-amino and 6-methoxy derivatives of 5-azacytidine I and VIII, respectively. Reaction of amidinourea IV with a mixture of chlorotrimethylsilane and triethylamine gave the blocked nucleoside V which was also formed by dealkylation of 6-ethoxy derivative VII with chlorotrimethylsilane or oxidation of tribenzoyl-5-azacytidine IX

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17

Díaz, A., M. T. Galceran, and F. Ventura. "Determination of estrogenic short ethoxy chain nonylphenols and metabolites in river and treated water by SPE (solid phase extraction) and SPME (solid phase microextraction)." Water Supply 3, no. 1-2 (2003): 329–34. http://dx.doi.org/10.2166/ws.2003.0121.

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Two solid-phase microextraction (SPME) procedures have been developed to determine short ethoxy chain nonylphenols and metabolites in water. A direct-SPME method has been used for the determination of short ethoxy chain nonylphenols and their brominated derivatives, whereas the in-sample derivatization headspace-SPME method has proved to be suitable for the simultaneous determination of short ethoxy nonylphenols and their acidic metabolites. Several parameters affecting both SPME procedures, such as extraction mode, fiber selection, extraction time, effect of organic modifiers, derivatization

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18

Lazewski, Dawid, Malgorzata Kucinska, Edward Potapskiy, et al. "Enhanced Cytotoxic Activity of PEGylated Curcumin Derivatives: Synthesis, Structure–Activity Evaluation, and Biological Activity." International Journal of Molecular Sciences 24, no. 2 (2023): 1467. http://dx.doi.org/10.3390/ijms24021467.

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Curcumin has been modified in various ways to broaden its application in medicine and address its limitations. In this study, we present a series of curcumin-based derivatives obtained by replacing the hydroxy groups in the feruloyl moiety with polyethylene glycol (PEG) chains and the addition of the BF2 moiety to the carbonyl groups. Tested compounds were screened for their cytotoxic activity toward two bladder cancer cell lines, 5637 and SCaBER, and a noncancerous cell line derived from lung fibroblasts (MRC-5). Cell viability was analyzed under normoxic and hypoxic conditions (1% oxygen). S

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19

Polozov, Alexandre M., Sheldon E. Cremer, and Phillip E. Fanwick. "Stereospecific thionation of 2-ethoxy-1,2-oxaphosphorinane 2-oxide and its derivatives with Lawesson's reagent." Canadian Journal of Chemistry 77, no. 7 (1999): 1274–80. http://dx.doi.org/10.1139/v99-125.

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The parent phostone, 2-ethoxy-1,2-oxaphosphorinane 2-oxide 1, and derivatives with substituents at the 3-position (methyl, phenyl, and benzyl; compounds 2-4) were converted with Lawesson's reagent to provide the corresponding sulfide analogues 5-8 in moderate yields. The conversion of 2-4 occurred with retention of configuration at the phosphorus center. This was implied from the relative Rf values and 13C and 31P NMR chemical shifts of the individual isomers and confirmed for the transformation of 3b to 7b by X-ray structures of each of these. Oxidation of 7b, 8a, and 8b with m-chloroperoxybe

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20

Matsumoto, Yohei, Kosuke Yamamoto, Masami Kuriyama, Koyo Nishida, and Osamu Onomura. "Regioselective Addition of Quinoline Derivatives to Carbonyl Compounds via Palladium-Catalyzed Umpolung with Diethylzinc." Synthesis 51, no. 08 (2019): 1795–802. http://dx.doi.org/10.1055/s-0037-1610682.

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An efficient method for the C-4-selective addition of quinoline derivatives to carbonyl compounds is described. The combination of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinolines (EEDQs) with a palladium catalyst and diethylzinc generates nucleophilic allyl species which undergo addition to various aldehydes and ketones. C-4-Substituted quinoline derivatives are obtained in high to excellent yields with moderate diastereoselectivities.

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21

Souza, P., M. A. Mendiola, A. Arquero, V. Fernández, E. Gutiérrez-Puebla, and C. Ruiz-Valero. "Copper(II) Complexes of Hydrazone Derivatives." Zeitschrift für Naturforschung B 49, no. 2 (1994): 263–71. http://dx.doi.org/10.1515/znb-1994-0219.

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Three benzil based, macrocyclic oxygen-, nitrogen-, and sulfur-containing ligands, (3,4,10,11 -tetraphenyl-1,2,5,6,8,9,12,13-octaazacyclotetradeca-7,14-dithione-2,4,9,11 -tetraene) ethanol (L1), 10,1 l-diethoxy-3,4,10,11-tetraphenyl-1,2,5,6,8,9,12,13-octaazacyclotetradeca- 7.14-dithione-2,4-diene (L2), (3,4,10,11 -tetraphenyl-1,2,5,6,8,9,12,13-octaazacyclotetradeca- 7.14-dione-2,4,9,l 1-tetraene) ethanol (L3); a cyclic ligand, 6-ethoxy-l,6-diphenyl-4-oxo- 3,4,5,6-tetrahydro-2,3,5-triazine (L5) and two open chain ligands, benzilsemicarbazone (L6) and benzilbisthiosemicarbazone (L4) are reported

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22

Sandoval-Altamirano, C., J. R. De la Fuente, E. Berrios, et al. "Photophysical characterization of hydroxy and ethoxy phenalenone derivatives." Journal of Photochemistry and Photobiology A: Chemistry 353 (February 2018): 349–57. http://dx.doi.org/10.1016/j.jphotochem.2017.11.049.

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23

Monti, Donato, Alessandra Pastorini, Mariano Venanzi, Stefano Borocci, and Giovanna Mancini. "Spectroscopic studies on the selective inclusion of amphiphilised porphyrin derivatives in micellar phases." Journal of Porphyrins and Phthalocyanines 07, no. 03 (2003): 181–90. http://dx.doi.org/10.1142/s1088424603000252.

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The inclusion behavior of [5-(4-(3-trimethylammonium)propyloxyphenyl)-10,15,20-tryphenylporphyrin] chloride( 1H 2), 2-[2-(2-(4-(10,15,20-triphenyl-5-porphyrinyl)-phenoxy)-ethoxy)ethoxy]ethanol (2 H 2), and their Mn ( III ) derivatives, 1MnCl and 2MnCl, respectively, in micellar phases of CTAB and Brij 35 aqueous solutions has been studied by means of several spectroscopic techniques. The results obtained show that a suitable functionalisation of the periphery of the porphyrin macrocycle influences the specificity of their binding to different micellar aggregates. This, consequently, allows for

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24

El-Hashash, M. A., K. M. Darwish, S. A. Rizk, and F. A. El-Bassiouny. "The Reactivity of 2-Ethoxy-4-Chloroquinazoline and Its Use in Synthesis of Novel Quinazoline Derivatives." Organic Chemistry International 2011 (December 28, 2011): 1–7. http://dx.doi.org/10.1155/2011/295491.

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The behavior of 2-ethoxy-4-chloroquinazoline 2 towards various nitrogen nucleophiles, namely: thiosemicarbazide, sodium azide, glucosamine, ethanol, and hydrazine hydrate has been discussed. Also, the behavior of 4-(2-ethoxyquinazolin-4-yl)thiosemicarbazide towards one-carbon, for example, ethyl chloroformate, and two-carbon donors, for example, ethyl chloroacetate and diethyl oxalate has been investigated. On the other hand, new 5-ethoxy-2-substituted[1,2,4]-triazolo-[1,5-c]quinazoline derivatives have been obtained by ring closure accompanied with Dimroth rearrangement through the interactio

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25

Tun Nur Iskandar, Nur Amanina Juniasari, Yeap Guan-Yeow, Nobuyuki Maeta, et al. "Anisotropic and magnetic properties in non-metal and non-radical organic aggregates of tri-substituted phenyl derivatives." New Journal of Chemistry 44, no. 1 (2020): 210–17. http://dx.doi.org/10.1039/c9nj02730k.

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A new series of tri-substituted phenyl derivatives containing an aromatic imine unit and biphenyl ester possessing various numbers of carbon atoms at the terminal alkoxy chain, OC<sub>n</sub>H<sub>2n+1</sub> (n = 7–12), along with a lateral o-ethoxy substituent.

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26

Platonova, Ya B., Z. A. Tarasov, A. N. Volov, N. A. Volov, and S. V. Savilov. "Design, synthesis and antiarrhythmic activity of new amide derivatives of indole-3-carboxylic acid." Журнал органической химии 59, no. 12 (2023): 1608–19. http://dx.doi.org/10.31857/s0514749223120054.

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The hERG (human ether-à-go-go-related gene) potassium channel has elicited intense scientific interest due to its counter-intuitive kinetics and its association with arrhythmia and sudden death. Kv1.5 potassium channel, encoded by KCNA5, is a promising target for the treatment of atrial fibrillation, one of the common arrhythmia. A new indole derivatives were synthesized via reaction of indole-3-carboxylic acid with 4-[2-(diethylamino)ethoxy]aniline under peptide coupling protocol in DMF with good yields and evaluated their antiarrythmic activity. Among them, 2-butyl- N -{4-[2-(diethylamino)et

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27

Niaz, Falak, Muhammad Faheem, Mutiullah Khattak, et al. "Antibacterial and Antibiofilm Activity of Juglone Derivatives against Enterococcus faecalis: An In Silico and In Vitro Approach." BioMed Research International 2022 (November 10, 2022): 1–11. http://dx.doi.org/10.1155/2022/6197375.

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Enterococcus faecalis is a Gram-positive bacterium that is normally found in the gastrointestinal tract of humans and animals. E. faecalis is an opportunistic pathogen that causes a number of invasive and noninvasive infections. The emergence of multidrug resistance and biofilm formation by the bacterium have rendered the treatment of E. faecalis infections very difficult. Due its high rate of resistance and biofilm formation, there are very few options of treatment. Therefore, the current study was designed to evaluate the antibacterial and biofilm activities of juglone derivatives such as 2-

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28

Meng, Qi, Gui Yong Wu, Ying Shao, and Xiao Qiang Sun. "Convenient Synthesis and Characterization of Star-Shaped Dendrimers: 2,4,6-Trisubstituted 1,3,5-Triazine Derivatives." Advanced Materials Research 396-398 (November 2011): 2476–84. http://dx.doi.org/10.4028/www.scientific.net/amr.396-398.2476.

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A serial of novel star-shaped 2,4,6-trisubstituted 1,3,5-triazine (s-triazine) dendrimers were synthesized via step-by-step nucleophilic substitution starting from 2,4,6-trichloro-1,3,5-triazine, and were characterized by1H,13C NMR, FT-IR and ESI-MS spectra. The crystal structures for 2b, 2d and 4c have been determined by X-ray diffraction analysis, which indicate that there are hydrogen bonding and short contact interactions existing in intermolecules result in forming three-dimensional network architecture. D NMR experiments demonstrate that symmetrical trialkylamino-s-triazine shows correla

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29

Bartovič, Alexander, Dušan Ilavský, Ondrej Šimo, Lubomír Zalibera, Anna Belicová, and Milan Seman. "Synthesis of Nitro-Substituted 4-Oxo-4H-pyrimido[2,1-b]benzothiazole-3-carboxylic Acids and Their Spectral Characteristics." Collection of Czechoslovak Chemical Communications 60, no. 4 (1995): 583–93. http://dx.doi.org/10.1135/cccc19950583.

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The Gould-Jacobs reaction of all position isomeric 2-aminonitrobenzothiazoles II with diethyl ethoxy- methylenemalonate has been studied. The structure of substitution (IV) and cyclization (VI) products and of the corresponding acids (VIII) was confirmed by elemental analysis, IR, UV, 1H and 13C NMR spectra. Analogous derivatives III, V and VII, derived from the unsubstituted 2-aminobenzothiazole I, were used as standards in interpretation of the spectra. The synthesized derivatives I - VIII were tested for antimicrobial activity.

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Barut, Burak, Ayşenur Sofuoğlu, Zekeriya Biyiklioglu, and Arzu Özel. "The water soluble peripherally tetra-substituted zinc(ii), manganese(iii) and copper(ii) phthalocyanines as new potential anticancer agents." Dalton Transactions 45, no. 36 (2016): 14301–10. http://dx.doi.org/10.1039/c6dt02720b.

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In this study, [2-(2-morpholin-4-ylethoxy)ethoxy] group substituted zinc(ii), manganese(iii) and copper(ii) phthalocyanines 2–4 and their water soluble derivatives 2a, 3a and 4a were synthesized and the interactions of compounds 2a, 3a and 4a with CT-DNA and supercoiled pBR322 plasmid DNA were investigated.

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31

Ridley, DD, and GW Simpson. "Further Reactions in the Tetrahydroazocin-2(1h)-one Series." Australian Journal of Chemistry 39, no. 4 (1986): 687. http://dx.doi.org/10.1071/ch9860687.

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5,6,7,8-Tetrahydroazocin-2(1H)-one and the 3-phenylthio- and 3- phenylsulfonyl-substituted derivatives have been converted into the corresponding 2-ethoxy-5,6,7,8-tetrahydroazocines with Meerwein's reagent. Upon irradiation under mercury lamp at longer wavelengths (Pyrex vessels) these compounds are inert, but at shorter wavelengths (quartz vessels) polymeric materials form with no evidence of intramolecular ring cyclization. Reaction of the lactams with bases, and with t-butyl hypochlorite, are reported, and these reactions lead to a variety of azocin-2(1H)-one derivatives.

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32

H., A. Latif, and A. Elrady E. "Simple synthesis of some new heterocyclic derivatives incorporation coumarin -2-one moiety." Chemistry International 3, no. 3 (2017): 487–93. https://doi.org/10.5281/zenodo.1473410.

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3-(1-ethoxy-3-oxo-3-phenylpropyle-1-enyl)-2H-coumarin-2-one (2), had been synthesized and reacted with some selected reagents such as hydrazine hydrate, urea, cyanoacetamide, cyanoacetohydrazide, orthophenylene diamine, ortho-aminophenol and 5-aminotriazole in ethanol piperidine solution to afford new multisubtituted 3-(pyrazol, pyrimidine, pyridine, diazepine, oxazepin, triazol)-2H- coumarin-2-one derivatives.

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33

Tewari, Ashish Kumar, Priyanka Srivastava, Ved P. Singh, et al. "Selective induced polarization through electron transfer in acetone and pyrazole ester derivatives via C–H⋯OC interaction." New J. Chem. 38, no. 10 (2014): 4885–92. http://dx.doi.org/10.1039/c4nj00679h.

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A set of organic compounds (pyrazole ester derivatives,viz.5-[3-(substituted)-propoxy]-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester and 5-[2-(substituted)-ethoxy]-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester) was synthesized and their affinity and stability towards the acetone molecule were tested by NMR.

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34

Heleyová, Katarína, and Dušan Ilavský. "Gould-Jacobs Reaction of 5- and 6-Amino-2-substitutedBenzoxazoles. III. Reaction with 3-Ethoxy-2-cyanopropenonitrile and Ethyl 3-Ethoxy-2-cyanopropenoate." Collection of Czechoslovak Chemical Communications 62, no. 1 (1997): 99–108. http://dx.doi.org/10.1135/cccc19970099.

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Nucleophilic reaction of 5-amino- (1) and 6-amino-2-substituted benzoxazoles (2) with 3-ethoxy-2-cyanopropenonitrile (3) afforded the respective benzoxazolylaminomethylenemalononitriles 5 and 6. The amino derivatives 1 and 2 reacted with ethyl 3-ethoxy-2-cyanopropenoate (4) to give the corresponding esters of benzoxazolylamino-2-cyanopropenoic acid 7 and 8, respectively. The products 7 on thermal cyclization at 250-260 °C in a mixture of diphenyl ether and biphenyl afforded a mixture of angularly and linearly annelated 5-nitrile-4-oxooxazolo[4,5-f]quinoline 9 and 7-nitrile-8-oxooxazolo[5,4-g]q

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35

Zhao, Xilin, Jian-Ying Wang, Chen Xu, et al. "Killing of Staphylococcus aureus by C-8-Methoxy Fluoroquinolones." Antimicrobial Agents and Chemotherapy 42, no. 4 (1998): 956–58. http://dx.doi.org/10.1128/aac.42.4.956.

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ABSTRACT C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.

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36

Iravani, Samin, and Abbas Ali Esmaeili. "One-pot synthesis of 4-ethyl 2,3-dimethyl 1-(5-aryl-1,3,4-thiadiazol-2-yl)-5-oxo-2,5-dihydro-1H-pyrrole-2,3,4-tricarboxylate derivatives via intramolecular Wittig reaction." Journal of Chemical Research 44, no. 7-8 (2020): 403–9. http://dx.doi.org/10.1177/1747519820903291.

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A facile one-pot synthesis of highly functionalized dialkyl 1-(5-aryl-1,3,4-thiadiazol-2-yl)-4-ethoxy-5-oxo-2,5-dihydro-1 H-pyrrole-2,3-dicarboxylate derivatives via the reaction between acetylenic esters, triphenylphosphine, and ethyl 2-[(5-aryl-1,3,4-thiadiazol-2-yl)amino]-2-oxoacetate is developed. The structure of the products is confirmed by spectroscopic methods.

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37

Edwards, Oliver E., Austin M. Greaves, and Wing-Wah Sy. "Reactions of 1,2-dehydropyrrolidin-5-one with 1,3-dienes. Synthesis of dl-gephyrotoxin 223AB." Canadian Journal of Chemistry 66, no. 5 (1988): 1163–72. http://dx.doi.org/10.1139/v88-191.

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Evidence is presented that the regiospecific and often stereospecific pseudo-Diels–Alder reactions of 1,3-dienes with N-acyl immonium salts, derived from 5-ethoxy-2-pyrrolidinone, are stepwise reactions. 6,7-Dehydroindolizidinones, unsaturated lactam esters, and new indene and furan derivatives are described. A synthesis of dl-gephyrotoxin 223AB (indolizidine 223AB) from trans-1,3-heptadiene was achieved.

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38

Wery, Guillaume, Karol Pastucha, Koen Robeyns, and Tom Leyssens. "The Inability of Metal Coordination to Control the Regioselectivity of Dimerization of Trans-Cinnamic Acid Derivatives." Crystals 14, no. 6 (2024): 530. http://dx.doi.org/10.3390/cryst14060530.

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Upon exposure to irradiation, trans-cinnamic acid can dimerize, producing truxinic and truxillic acids, regioisomers distinguished by the relative arrangement of acid and phenyl groups on the formed cyclobutane ring. Solid-state dimerization, governed by Schmidt’s specified conditions, hinges on the initial molecular setup. This study endeavors to manipulate the reaction’s outcome in the solid state. To achieve this, the target molecule was paired with metals (Ag, Cu) to modify molecular orientation in the solid. Investigated derivatives included para-hydroxy-trans-cinnamic acid, ortho-methoxy

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39

ZHANALIYEVA, R. N., B. B. TORSYKBAYEVA, M. O. ALTYNBEKOVA, B. S. IMANGALIYEVA, and A. Zh NAZAROVA. "SYNTHESIS OF 2- (2I – ACYLOXY-ETHOXY) ETHYL CHLORIDE AND THEIR INTERACTION WITH AMIDES AND ALKALI METAL RHODANIDES." Periódico Tchê Química 16, no. 32 (2019): 996–1009. http://dx.doi.org/10.52571/ptq.v16.n32.2019.1013_periodico32_pgs_996_1009.pdf.

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This work is aimed at studying the reaction of nucleophilic substitution of the chlorine atom in 2-(2'-acyloxy-ethoxy) ethylchlorides with amines and a rhodanide ion and developing methods of synthesizing a 2-(2'-acyloxy-ethoxy) ethylchlorides, rhodanides, and their derivatives previously unknown in specialized literature. In the chlorohydrin molecule of diethylene glycol, there are two reaction centers that allow carrying out nucleophilic substitution reactions, as well as reactions that promote them with electrophilic reagents. The authors carried out several experiments for acylating diethy

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40

Chabukswar, Anuruddha, Prajakta V. Adsule, Swati Jagdale, Dishank V. Purandare, Kunal Raut, and Yash Kale. "Synthesis, Molecular Modeling and Cytotoxicity Study of New 3-Phenyl Coumarin Derivatives against in vitro Cell Lines." Asian Journal of Chemistry 36, no. 5 (2024): 1061–66. http://dx.doi.org/10.14233/ajchem.2024.31269.

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In pursuit of more effective cancer treatments, researchers embarked on a study to enhance the coumarin derivative’s therapeutic potential. These compounds, known for their anticancer properties, have faced challenges such as increased toxicity and drug resistance. The research aimed to design, synthesize and assess new 3-phenyl coumarin derivatives specifically for breast and lung cancer treatment. Utilizing 3-oxoacyl-reductase (1T8I), a series of compounds were synthesized from aromatic aldehydes and phenylacetic acid. Among the synthesized 11 compounds that were examined, compounds C01, C04

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41

Nikitina, Anastasiya V., Irina I. Semina, Afrida Z. Baychurina, Anastasia A. Vivolaneс, and Diana V. Akhmedieva. "New derivatives of phosphorus-containing compounds with amino acid and triazolethione fragments are potential drugs that improve memory and cognitive functions." Kazan medical journal 104, no. 1 (2023): 72–80. http://dx.doi.org/10.17816/kmj108603.

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Background. Cognitive disorders are often the main symptom of neurological and mental diseases. Given the variety of mechanisms for the development of these changes, it is necessary to search for and develop new drugs. Aim. An experimental study of the behavioral effects of new derivatives of phosphorus-containing compounds with amino acid and triazolethione fragments as potential agents that improve memory and cognitive functions. Material and methods. A computer prediction of the activity of 43 compounds (the Prediction Activity Spectral of Substances and Pharma expert programs)

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42

Bakalska, Rumyana, Bojidarka Ivanova, and Tsonko Kolev. "Solid-state IR-LD spectroscopy of codeine and N-norcodeine derivatives." Open Chemistry 4, no. 3 (2006): 533–42. http://dx.doi.org/10.2478/s11532-006-0018-0.

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AbstractLinear-dichroic infrared spectra (IR-LD) of 3-ethoxy-4-(N-norcodeino-)cyclobutene-1,2-dione (1) and codeine dihydrogenphosphate (Codeinum phosphoricum) (2), oriented as solid suspensions in nematic liquid crystals, have been measured. IR characteristic band assignments were made, and used in stereo-structural predictions. The results were compared with crystallographic structures of similar organic systems, and found to be in good agreement.

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43

Bzowska, Agnieszka, Lucyna Magnowska, and Zygmunt Kazimierczuk. "Synthesis of 6-Aryloxy- and 6-Arylalkoxy-2-chloropurines and Their Interactions with Purine Nucleoside Phosphorylase from Escherichia coli." Zeitschrift für Naturforschung C 54, no. 12 (1999): 1055–67. http://dx.doi.org/10.1515/znc-1999-1210.

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The phase transfer method was applied to perform the nucleophilic substitution of 2,6- dichloropurines by modified arylalkyl alcohol or phenols. Since under these conditions only the 6-halogen is exchanged, this method gives 2-chloro-6-aryloxy- and 2-chloro-6-arylalkoxypurines. 2-Chloro-6-benzylthiopurine was synthesized by alkylation of 2-chloro-6-thiopurine with benzyl bromide. The stereoisomers of 2-chloro-6-(1-phenyl-1-ethoxy)purine were obtained from R- and S-enantiomers of sec.-phenylethylalcohol and 2,6-dichloropurine. All derivatives were tested for inhibition with purified hexameric E

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44

Ahmed, Hussein. "Analgesics and Anticancer of Some Synthesized 2- Benzimidazole Derivatives." Medicinal Chemistry 11, no. 10 (2021): 10. https://doi.org/10.5281/zenodo.10669299.

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This work, contain some new compounds from benzimidazole derivatives, which synthesized by condensation of Orthophenylene diamine and Carbon disulfide resulting 2-Mercapto-benzimidazole which treated by alcoholic potassium hydroxide forming potassium salt of 2- mercaptobenzimidazole which reacts with different substances (alkyl chloroacetates, chloroacetic chloride, alkyl halides) also the ethoxy carbonyl methyl thiobenzimidazole reacts with different amines in addition to chloromethyl benzimidazole which resulted from the reaction between orthophenylene diamine and chloroacetic acid, which re

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45

Chung, Kun Hoe, Kwang Yun Cho, Yasuko Asami, Nobutaka Takahashi, and Shigeo Yoshida. "New 4-Hydroxypyridine and 4-Hydroxyquinoline Derivatives as Inhibitors of NADH-ubiquinone Reductase in the Respiratory Chain." Zeitschrift für Naturforschung C 44, no. 7-8 (1989): 609–16. http://dx.doi.org/10.1515/znc-1989-7-811.

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Many derivatives of 2,3-dim ethoxy-4-hydroxypyridine, which were designed from examination of the structure-activity relationship of piericidins, were tested for inhibition of NADH-UQ reductase. The lipophilic side chain of those compounds was indicated to be a key part for activity and its optimal length was conjectured. By the use of two different phases of assay material, intact mitochondria and submitochondria, the size of a membrane effect was shown to depend on the structure of the side chain. 4-Hydroxyquinoline derivatives were also tested for an analogous role in relation to the electr

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46

Havlíček, Jaroslav, Zuzana Mandelová, Ruediger Weisemann, Ivo Střelec, Lukáš Plaček, and Stanislav Rádl. "Identification, synthesis and structural determination of some impurities of candesartan cilexetil." Collection of Czechoslovak Chemical Communications 74, no. 2 (2009): 347–62. http://dx.doi.org/10.1135/cccc2008072.

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All principal candesartan cilexetil impurities and/or degradation products were synthesized and identified. The differentiation of N-1 and N-2 ethylated candesartan cilexetil derivatives was performed using 1D and 2D NMR experiments. The influence of the magnetic field on the resolution and sensitivity of NMR experiments is shown. Selective hydrolysis of these compounds then provided corresponding producrs of hydrolysis of the ethoxy group.

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47

Ohta, Tetsuo, Hironori Fujisawa, Yasuto Nakai та Isao Furukawa. "Synthesis of 3-Ethoxyisoxazole Derivatives and 3-Ethoxy-1H-pyrazole Derivatives fromβ-Oxo Thionoesters". Bulletin of the Chemical Society of Japan 73, № 8 (2000): 1861–64. http://dx.doi.org/10.1246/bcsj.73.1861.

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48

Nandhikumar, R., and K. Subramani. "Microwave Synthesis, Characterization and Antimicrobial activity of some Chromene derivatives." Oriental Journal of Chemistry 34, no. 4 (2018): 2106–13. http://dx.doi.org/10.13005/ojc/3404051.

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In the present study the synthesis of Chromene derivatives 7-ethyl-2, 3, 4, 4a-tetrahydro-1H-xanthen-1-one (3a), 7-bromo-2, 3, and 4, 4a-tetrahydro-1 H-xanthen-1-one (3b), 5-ethoxy-2, 3, and 4, 4a-tetrahydro-1 H-xanthen-1-one (3c),7-ethyl-3, 3a-dihydrocyclopenta[b]Chromen-1(2H)-one (4a), 7-bromo-3, 3a-dihydrocyclopenta[b]Chromen-1(2H)-one (4b),and 5-ethoxy-3, 3a-dihydrocyclopenta[b]Chromen-1(2H)-one (4c) have been reported by the reaction of substituted Salicylaldehyde with 2-cyclopenten-1-one/2-cyclohexen-1-one in the presence of ammonium acetate with ethanol using microwave-irradiation. The

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49

Ghalehassadi, Mohammad, Maryam Ziaei, and Ebrahim Rezaii. "Synthesis of some silyl derivatives of graphene oxide." Main Group Chemistry 20, no. 2 (2021): 119–32. http://dx.doi.org/10.3233/mgc-201217.

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In this work, we synthesized some organosilicon derivatives of graphene oxide (GO) containing various groups such as trimethyl, triethyl, dimethyl-tert-Bu, and dimethyl-vinyl. Also, some reactions were done in the presence of DES, as catalyst. This green catalyst improved the yields of reactions successfully. Synthesis of methoxy, and ethoxy vinyl silyl ethers of GO were done. In this work, hybrid organic-inorganic was done. In the next step, network polymers of GO with styrene, and methacrylic acid (MAA) were done. Incorporation of organosilicon groups were modified GO properties for example

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50

Vishnupriya, R., J. Suresh, S. Maharani, and R. Ranjith Kumar. "C—H...O and C—H...N interactions in three hexahydrocycloocta[b]pyridine-3-carbonitriles." Acta Crystallographica Section C Structural Chemistry 70, no. 2 (2014): 236–40. http://dx.doi.org/10.1107/s2053229614000291.

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The structures of three new pyridine derivatives, 2-methoxy-4-(4-methoxyphenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonitrile, C20H22N2O2, (I), 2-ethoxy-4-(3-nitrophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonitrile, C20H21N3O3, (II), and 2-ethoxy-4-(4-methoxyphenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonitrile, C21H24N2O2, (III), differ in the nature of the substituents either at the 2-position of the central pyridine ring or on the pendent aryl ring. This simple change in the structure substantially alters the intermolecular interaction patterns. The sub

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