Dissertations / Theses on the topic 'ETOM'
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Jezl, Tomáš. "Využití frameworku NGOSS při zavádění SOA v prostředí telekomunikačního operátora." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-7608.
Full textSilva, Ranério Fernandes da. "Uma abordagem convergente para o mapeamento de processos ITIL similares aos do modelo eTOM." reponame:Repositório Institucional da UnB, 2007. http://repositorio.unb.br/handle/10482/6732.
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Este trabalho apresenta uma proposta de racionalização dos processos de gerenciamento de serviços para uma empresa de Telecomunicações, através da utilização dos modelos de referência, eTOM em telecomunicações, e ITIL, em TI, como referência para o gerenciamento dos processos de negócio de uma empresa de telecomunicações e das melhores práticas de gerenciamento de serviços de TI. A abordagem da racionalização dos processos é focalizada no atendimento aos serviços convergentes. Neste trabalho é feita a conceituação da Governança Corporativa e de Governança de TI e suas relações com a lei Sarbanes Oxley e outras regulamentações externas. Estudou-se o framework de melhores práticas para o gerenciamento de serviços de TI, ITIL, e o seu alinhamento com o negócio. É realizada uma conceituação do framework NGOSS (New Generation Operation Support System) e foi realizado um estudo detalhado do Enhanced Telecom Operation Map (eTOM). Aplicou-se também uma atualização e entendimento do cenário atual de telecomunicações e seus relacionamentos com os processos de convergência tecnológica e de serviços. Como ferramenta de apoio para as empresas na adoção de processos para suportar serviços convergentes, foi apresentado o desenvolvimento de proposta de modelo de utilização colaborativa entre os frameworks eTOM e ITIL. Como resultado, tem-se uma avaliação da aplicação de um modelo de utilização colaborativa do eTOM e ITIL, suas oportunidades de aplicação, um entendimento do nível maturidade da convergência dos processos e a mensuração dos ganhos proporcionados pela utilização de um framework convergente. ________________________________________________________________________________ ABSTRACT
This work presents a process optimization proposal for a telecommunications company services management processes, using he reference models eTOM, for telecommunications, and ITIL, for IT, as references, respectively, for the business processes management in a telecommunications company and the best practices in services management of IT. The approach for the process improvement is in the fulfillment of the convergent services. In this work the concepts of Corporative Governance and IT Governance are developed and their relationship with the Sarbanes Oxley law and other regulations are detailed. The IT Service Management best practices framework, ITIL, was analyzed, and its alignment with the business was determined. The conceptualization of the framework NGOSS (New Generation Operation Support System) was carried out through a detailed study of the Enhanced Telecom Operation Map (eTOM). Besides, it was presented an information update of the current telecommunications scene and its relationship with the technological convergence processes and services. As a support tool for the companies adopting convergent support services, the development of a collaboration model involving the frameworks eTOM and ITIL was presented. As a result, one has an application evaluation of the convergent model using eTOM and ITIL, its application opportunities, agreement convergence level maturity processes and the benefits of the use of a convergent framework.
Alves, Marcelo Giovane. "Automa??o do processo de ger?ncia de for?a de trabalho terceirizada no setor de telecomunica??es." Pontif?cia Universidade Cat?lica de Campinas, 2007. http://tede.bibliotecadigital.puc-campinas.edu.br:8080/jspui/handle/tede/483.
Full textAfter the spilt of TELEBRAS that started the consolidation of the Telecommunications in the Brazilian market, which goes through the reduction in the operational costs of the operators of Personal Mobile Service (PMS). The integration of the business processes with the outsourcing companies shall be considered as part of the Work Force Management (WFM) process that was transferred outside the operator s border. The outsourcing of work force should be used as main condition in reduction of these costs. This document presents a new model for implementation of the WFM associated with a Service level Agreement (SLA) with performance indicators and targets pre-established in a signed contract between the parties, and focused on the macro process for guarantee of quality in the enhanced Telecommunications Operation Map (eTOM). This model allows the process to manage outside the operator s borders by using resources B2B, WAP and SMS in external environment defined by the eTOM model, as for proper human resources and as well for outsourcing companies in a more collaborative form.
Ap?s a cis?o da TELEBR?S, deu-se in?cio ? consolida??o do mercado brasileiro de telecomunica??es que passa pela redu??o dos custos operacionais das operadoras de Servi?o M?vel Pessoal (SMP). A integra??o dos processos de neg?cio com as empresas terceirizadas deve considerar que parte do processo de Ger?ncia da For?a de Trabalho (GFT) foi deslocado para fora das fronteiras da operadora. A terceiriza??o da for?a de trabalho vem sendo utilizada como principal forma de redu??o destes custos. Este trabalho, apresenta um novo modelo para a implementa??o da GFT associada a um Acordo de N?vel de Servi?o (Service Level Agreement - SLA) com indicadores de desempenho e metas pr?-estabelecidos num contrato firmado entre as partes e focado no macro processo de garantia de qualidade do enhanced Telecommunications Operation Map (eTOM). Esse modelo, permite gerenciar o processo al?m das fronteiras da operadora utilizando recursos B2B, WAP e SMS no ambiente externo definido pelo modelo eTOM, tanto para recursos humanos pr?prios quanto para empresas terceirizadas de forma mais colaborativa.
Freitas, Filipe André Martins de. "O processo de elaboração de uma arquitectura de informação tendo em vista o CRM de duas empresas de telecomunicações portuguesas." Master's thesis, Instituto Superior de Economia e Gestão, 2009. http://hdl.handle.net/10400.5/1150.
Full textOs relacionamentos constituem uma das principais formas de diferenciação adoptadas pelas organizações na actualidade, sendo o CRM (Customer Relationship Management) a estratégia utilizada na procura da fidelização de relacionamentos com clientes. O sector das telecomunicações tem sofrido grandes alterações e tem sido marcado por uma vaga de fusões e alianças de empresas, parcerias estratégicas, entrada de novos actores e regulamentação assimétrica. O presente trabalho faz uma reflexão sobre como se processa a elaboração de uma arquitectura de informação, tendo em vista o sistema de informação de CRM de duas grandes empresas portuguesas de telecomunicações no seu processo de convergência/integração. Faz-se também a análise da framework eTOM, verificando os seus contributos práticos para as operadoras de telecomunicações. Para a realização do objectivo proposto foi desenvolvido um de estudo de caso único, onde se analisaram os três pilares do CRM; pessoas, processos e tecnologias. A recolha de dados foi efectuada através de entrevista, observação directa e análise documental. Como resultado observou-se que as características da gestão de topo, a cultura empresarial e a resistência à mudança são factores determinantes no processo de desenvolvimento e utilização bem sucedida de um sistema de CRM, factores estes que se consubstanciam num dos pilares que sustentam as organizações, as pessoas. Também são encontradas características que destacam a importância da tecnologia e dos processos mas observa-se que sozinhos não garantem o sucesso da adopção e utilização dos SI/TI (Sistemas de Informação/Tecnologias de Informação). Constatou-se também durante este estudo que a framework eTOM é um elemento facilitador das relações entre os três pilares do CRM para empresas do sector de telecomunicações.
Nowadays, organizations, adopts relationships as one of the main ways of differentiation, being the CRM (Customer Relationship Management) the strategy used for searching reliable relationships with clients. Telecommunications sector has suffered from major alterations and has been marked by a considerable number of fusions and alliances of enterprises, strategic partnerships, introduction of new actors and asymmetric regulation. This work reflects upon an elaboration of an information architecture, taking into consideration the Information Systems and the CRM of two great Portuguese telecommunications companies, in their convergence/integration process. Also the framework eTOM is analyzed, and its practical contributions for the telecommunications operators, checked. To reach the claimed goals, a unique case study was performed and the three CRM pillars were studied; people, processes and technologies. Data was collected from interviews, direct observation and documental analyses. In this case, top management, company culture and fear/resistance to changes are the principal factors conditioning the development and application of successful CRM systems, which depends mostly upon people, the key element of any enterprise. Technologies and processes are also important, but without worker involvement, do not assure successful use and adoption of IS/IT (Information Systems/Information Technologies). On the other hand, eTOM framework is an element that eases the relationships among the three pillars of CRM, for telecommunication sector enterprises.
Příhoda, Stanislav. "Vztah EA a vybraných referenčních modelů." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-162569.
Full textSalgado, Rojas Mario Rolando. "Rediseño del Proceso de Atención a los Técnicos y Soporte a la PGI en Telefónica CTC Chile." Tesis, Universidad de Chile, 2009. http://repositorio.uchile.cl/handle/2250/102103.
Full textFaro, Luiz Filipe de Almeida Tovar. "Técnicas para garantia de qualidade fim-a-fim em serviços de telecomunicações digitais." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/3/3141/tde-08012008-153141/.
Full textThis work presents a set of concepts, tools and methodologies that, if applied together, allow telecommunications service providers and developers to better fulfill their customers\' expectations. This set of tools was created by identifying and selecting concepts and methodologies originally developed for deployment on different industries: manufacturing, consumer goods development, communications network management, corporate management and so on. The selected tools include concepts from Total Quality Management, the works of the TeleManagement Forum and the models developed by the Brazilian National Foundation for Quality (FNQ). These selected concepts and methodologies were then positioned over a set of conceptual maps and diagrams that aim to model the interaction between consumers, their service providers and the entities that develop services for the later. As such, this work starts from a broad range of techniques that come from very different knowledge fields and proposes a way to integrate them in an optimized set for application on the telecommunications industry.
Gottvaldsson, Frida, and Emma Jakobsson. "Offentligt Etos : En Problematisk Gestaltning." Thesis, Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-26668.
Full textOngolo, Adrien. "Fondement rationnel de l'idée d'evu eton." Lille 3 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37600129c.
Full textDunlay, Samantha, and Jonathan M. Peterson. "CTRP3 Prevents ETOH- Induced Hepatocyte Apoptosis." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/127.
Full textOngolo, Adrien. "Fondement rationnel de l'idée d'Evu Eton." Grenoble 2, 1986. http://www.theses.fr/1986GRE29045.
Full textAlajuuma, S. (Sami). "Tuotantoinformaation hallinta ETO-ympäristössä." Master's thesis, University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201702091155.
Full textThe aim of this master’s thesis was to improve production management and controllability and also try to reduce nonproductive work in assembly. The biggest problems in trying to improve the company’s production management and control are related to the decentralized information management system. The needed data can be difficult to find and utilize. Presently the company is using many data systems that do not communicate with each other. Employing a new centralized information management system is a time consuming process. Therefore, the focus of this thesis is on practical improvement that can be realized in the short term. The research strategy was chosen the literature survey, which was taken into account a limited group of materials and surveys. Production management problems were tackled by comparing theoretical alternatives to current practices. As a result the production system in use, FLOW, was redesigned with an objective to integrate features of commercial manufacturing execution systems into it. Key performance indicators (KPI) were customized for engineered-to-order (ETO) assembly work with an aim to improve production control. Implementation of the new KPI’s required changes to the user interface, and to the data gathering. While planning the user interface improvements were made to include checklists for assembly and to reduce unprofitable work. In practice the improvements help in finding needed information and reduce the amount of tasks previously seen as complicated. In addition, a direct link from the user interface to the communication center webpage enables the user to give feedback and report safety observations or continuous improvement ideas. Planning the new user interface and the KPI’s was a success. Often reforms and improvements of working practices are received reluctantly. However, in this case also the assembly workers had a positive attitude towards the project. Involving the workforce in developing their own work was likely one of the reasons for this. The look of the newly designed user interface is clear, illustrative and modern. Users were generally satisfied with the improvements which were seen to facilitate daily work. All the data required by the KPI’s can now be gathered while previous unnecessarily fed entries have been removed. Workers on the shop floor are satisfied with the tablet computers and displays as they assist in performing work tasks and reading instructions. The new KPI’s will be easy to display on the shop floor in real time. It will also be possible to summarize how well projects have succeeded, and highlight problems. We make the grade with the development of FLOW. Its features increasingly resemble those of commercial MES-systems
Wu, J. "Materials for electron trapping optical memory (ETOMS)." Thesis, Coventry University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289102.
Full textEkstrand, Rebecca, and Cathrin Nordqvist. "SOCIALSTYRELSENS OFFENTLIGA ETOS : Från demokrati till ekonomivärden?" Thesis, Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-45253.
Full textHocking, Catherine. "Cantus firmus procedures in the Eton Choirbook." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389848.
Full textWilliamson, Magnus. "The Eton choirbook : its institutional and historical background." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285407.
Full textKäkelä, Nikolas. "Customization-based interaction in ETO." Licentiate thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH, Logistik och verksamhetsledning, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-46868.
Full textKundanpassning är ett viktigt sätt för leverantörer att erbjuda värde till sina kunder och på så vis vara konkurrenskraftiga. Det finns en rad olika metoder som leverantörer kan anta för att erbjuda kundanpassning. Gemensamt är att någon form av interaktion mellan kund och leverantör förutsätts, då kundanpassning baseras på att involvera den enskilda kunden i att specificera den lösning som ska produceras. Det kan exempelvis göras genom att kunden tillåts välja mellan olika komponenter eller värden som definierats i förväg, som därefter monteras eller sätts samman enligt kundens önskemål. Eftersom möjligheterna till kundanpassning är tydligt definierade i förväg kan leverantören därför rationalisera deras procedur för att fånga upp kundkrav och föreslå en lämplig lösning. Denna metod skiljer sig från fall då kunden involveras redan i utvecklings, design, eller konstruktionsfasen, så kallade konstruktion-mot-order (engineer-to-order, ETO) scenarion. Kunden är i dessa fall inte bunden till fördefinierade möjligheter för kundanpassning, vilket gör att interaktionen som krävs för att definiera lösningen inte kan rationaliseras i samma utsträckning. I denna uppsats undersöks kundanpassningsbaserad interaktion i ETO, både med avsikt att förbättra förståelsen för interaktion i denna kontext som sådan men även för att erbjuda sätt att förklara hur vissa förhållningssätt till kundanpassning har implikationer för interaktion som skiljer sig från andra. Resultatet av forskningen utgörs av en redogörelse för hur interaktion tar sitt uttryck i ETO samt hur olika förhållningssätt till kundanpassning kan förstås för att tydliggöra deras innebörd för hur lösningar definieras.
Nana, Manga Augustine. "L'acquisition de l'inclusion des classes et de la conservation physique chez l'enfant Eton au Cameroun." Paris 10, 1993. http://www.theses.fr/1993PA100149.
Full textThis thesis deals with the development of structures operatoires it refers more precisely to the notion of class inclusion and of matter conservation. Our approach to this aims at testing of piaget about a cognitive development systel where the main stages necessarily follow cach other on an irreversible way. Therefore, we have adapted piaget's test to our experimenting milieu which is the eton milieu. We have obtained two kind of tests: a quite weakly adapted to the experimenting milieu one, and a strongly adaptad one. A 160 scholar children were shared out amongst four groups according to their age. From 6. 0 - 13. 11. Thanks to the results we were able to compare the rural milieu from the urban one, and the genevan milieu from the eton one. We found for instance that the eton's children could acquire both notion of inclusion and conservation. Nevertheless, because of the very few number of children who could include before the age of eleven comparatively to the results of piaget, we may wonder whether the eton child reaches the stage of logical answers without going through the empirical inclusion one. Also, the results from the test of conservation doesn't make obvious the piaget's stage of development. At last but not least, the analyse of variance shows that the adaptation of the tests is more important for the less successful part of the eton milieu. The answers of inclusion, of conservation and their justifications were studied according to the age, the milieu and the experimenting situation. They lead us to conclude to the existence of the distinctif culturel, this entity that deeply influence the setting of fundamental processes into functional system, and the way they are applied in any specific situation
Graziani, Elena. "Didattica della Lingua italiana L2: un'esperienza ad Eton College." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
Find full textZart, Paloma Catarina. "O ETOS SATÂNICO: A ORATÓRIA ENTRECORTADA DE UM REBELDE RENEGADO." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/9844.
Full textJohn Milton (1608-1674) viveu em um período marcado pela discussão religiosa. A guerra civil inglesa (1640) tivera um de seus suportes envolvendo a religião, textos literários foram compostos com alegorias bíblicas, e Milton, seguindo os hábitos de seu tempo, criou obras com influência sacra. O Paradise Lost, por causa disso, foi, durante muito tempo, observado à luz do mito bíblico que serviu de matéria base para a composição do épico. Antes dos românticos, poucos críticos ousaram sair da zona de conforto e ensaiaram uma análise que cuidava de outros aspectos além da contribuição de autores e obras clássicas ou do mito bíblico. Com os românticos, abriu-se definitivamente uma linha crítica atenta às personagens do Paradise Lost, em especial de Satã. Eles ouviram as vozes que dão vida à narrativa épica e descobriram um modelo para o seu próprio tempo. O Satã heróico e nobre dos românticos, no entanto, não responde à complexidade da personagem. Longe de ser uma mera materialização do mal, um elemento que possa ser culpado por todo o infortúnio, o Satã de Milton abriga em si vestígios do bem anterior. Vitimado pela compreensão de seu presente e abatido com as memórias do passado, a personagem coloca-se entre a imagem de grande líder exteriorizada aos outros anjos e as dúvidas que dominam os seus pensamentos. Esta dissertação tem por objetivo contrapor essas duas partes da personagem.
Grimanelli, de Besses Marie. "Contribution à l'analyse des qualifications : le cas des ETAM comptables." Grenoble 2, 1990. http://www.theses.fr/1990GRE21016.
Full textThe study's purpose is an analyse, in a dynamic view, of law and intermediate qualifications in accounting job. The approach is empirical in the main part. The first part presents the concepts used: dynamic system of sualifications, relations between technology and qualifications, qualifications in the firms. The second part analysis the general evolution of accounting qualifications with three viewpoint: - an analysis of tasks, - employment statistics (divide by economics branches, by qualification level, by school level - transformation in the school system. The third part is the report of directs observations in 8 firms, with differents characters. We can summarize the main results inthree points: - the dynamic approach of qualifications allows to understand some paradoxals cases in matter of employment: as the conjunction between high level of unemployment with lack of qualifications. - the accounting job desing is in a deep transformation. In the same time, and in an interactive way, the firms'demand in internal and specific accounting increase fastly and the news information's technologies allow this increasing with decreasing units costs. - instead, the differents ways of qualifications'management inthe firms have an high responsability in the results of this transformations in the matter of qualifications
Vildebrandt, Ems. "Omvårdnadsdiagnoser hos militärpersonal i relation till militärt etos – En litteraturöversikt." Thesis, Högskolan Dalarna, Omvårdnad, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:du-25246.
Full textBakgrund I enlighet med International Council of Nurses (ICN) etiska kod har sjuksköterskan ett ansvar för att varje person ska få en korrekt, tillfredsställande och kulturellt anpassad information som grund till sin vård och behandling. Militärkulturen ger upphov till en patientgrupp med unika behov och detta skall styra vården. Syfte Syftet är att genom en litteraturstudie förstå vilka omvårdnadsdiagnoser som är framträdande hos militärpersonal med relation till militärt etos. Metod En litteraturstudie av artiklar (n=20) genom sökningar i PubMed, Cinhal och Summon. Resultat Riskfyllt hälsobeteende var största temat följt av smärta och sömnproblematik. Hos militärpersonal var alkoholkonsumtion hög hos två tredjedelar, smärta hade högst prevalens, påverkan på sömnen återfanns i upp till hälften av personalen och viljan att söka vård var nedsatt. Stress, depression, smärtkonsekvenser samt påverkade familjerelationer och processer återfanns. Följder av tjänstgöringen var infektioner, hudskada, hudåkommor, hörselnedsättning och diarré. Slutsats Militärkulturen är unik och underrapporterar ohälsa, därför behövs det en förståelse för de framträdande omvårdnadsdiagnoserna för att kunna ge denna patientgrupp god vård.
Mackay, Lisa 1972. "Mode in the Salve Regina settings of the Eton College choirbook." Monash University, School of Historical Studies, 2002. http://arrow.monash.edu.au/hdl/1959.1/8207.
Full textLeung, Amy. "The role of the transcriptional co-repressor ETO2 in developmental haematopoiesis." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531976.
Full textOrtega-MartiÌnez, Olga. "Role of ethylene overproducer1 (ETO1) in the development of Arabidopsis thaliana." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426677.
Full textGofman, Larisa. "Role of Purinergic Receptor (P2X4) in EtOH-Mediated Microglial Immune Responses." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/315641.
Full textPh.D.
Ethanol (EtOH) abuse is the third leading cause of preventable death in the United States. Mounting evidence indicates that EtOH-induced neuropathology may result from multicellular responses in which microglia cells play a prominent role. Purinergic receptor signaling plays a key role in regulating microglial function and, more importantly, mediates EtOH-induced effects. In our current study we sought to determine the effects of EtOH on microglial cell function, specifically the role of purinergic receptor X4 (P2X4) in EtOH-mediated microglial responses. Our results show a significant up-regulation of P2X4 gene expression as analyzed by real-time qPCR and protein expression as analyzed by flow cytometry in embryonic stem cell-derived microglial cells (ESdM) after 48 hours of EtOH treatment, as compared to untreated controls. Calcium mobilization in EtOH treated ESdM cells was found to be P2X4R- dependent using 5-BDBD, a selective P2X4R antagonist. Blocking P2X4R signaling with 5-BDBD decreased the level of calcium mobilization compared to EtOH treatment alone. EtOH decreased migration of microglia towards fractalkine (CX3CL1) by 75% following 48 hours of treatment compared to control. CX3CL1-dependent migration was confirmed to be P2X4 receptor-dependent using the antagonist 5-BDBD, which reversed the effects as compared to EtOH alone. Similarly, 48 hours of EtOH treatment significantly decreased phagocytosis of microglia by 15% compared to control. 5-BDBD pre-treatment prior to EtOH treatment significantly increased microglial phagocytosis. These findings demonstrate that P2X4 receptor may play a role in modulating important regulatory functions in microglia in the context of EtOH abuse. P2X4R plays an important regulatory function in microglia. P2X4 is involved in a myriad of molecular signaling such as proliferation, activation of transcription factors, specifically through the MAPK pathway, and ATP signaling. Here, we also investigated the intracellular signal transduction pathway that influences P2X4R expression in microglia in response to EtOH. We found EtOH (100 mM) decreased phosphorylated AKT and extracellular signal-regulated kinase (ERK) cascades in ESdM cells. EtOH effect on ERK phosphorylation was completely inhibited by U0126, an inhibitor of MEK 1 and 2. However, PD98095, a potent inhibitor of MEK1 but a weak inhibitor of MEK2 had modest effect on phosphorylated ERK1/2 suggesting a possible role of MEK2-dependent ERK signaling in modulating EtOH induced effects on microglia. Utilization of 5-BDBD, a selective P2X4R antagonist reversed the EtOH-induced effect on phosphorylated AKT and ERK. Next we wanted to examine the effects of EtOH on transcription factor activity to determine the signaling mediators, which may play a role in EtOH-induced increase in P2X4R in microglia. EtOH increased transcriptional activity of NFκB, NFAT, and CREB,, however 5-BDBD blocked the effect on CREB transcriptional activity alone, suggesting a specific role of CREB in EtOH-induced expression of P2X4R in microglia. In summary, EtOH affects the expression of P2X4R in microglial cells and contributes to aberrant microglial effector function including phagocytosis and migration as well as alterations in calcium mobilization. Furthermore, pharmacological blockade with a selective P2X4R antagonist reversed the action, suggesting that P2X4R may play a role in mediating EtOH-induced effects on microglia. EtOH decreased expression of ERK and AKT, which was blocked with the P2X4R antagonist, suggesting EtOH effect may contribute to irregular microglial signaling. Investigations regarding transcription factor NFκB, NFAT and CREB activity in response to EtOH, all showed an increase after EtOH treatment, however P2X4R antagonist only had an effect on CREB, blocking the effect of EtOH on its activity. Determining the mechanism underlying EtOH-induced increase in P2X4R expression still remains unclear. This research was conducted to investigate the importance of P2X4R signaling in EtOH-mediate microglial function. Although many more questions remain unanswered, these experiments have provided evidence to target purinergic receptor X4 as a potential mediator of EtOH-induced effects in microglia.
Temple University--Theses
Schüle, Silke. "Peptid-basierte molekulare Therapieansätze zur Inhibierung der onkogenen Aktivität von AML1-ETO Etablierung eines Screening-Systems für ETO-interagierende Peptide /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968973183.
Full textLindström, Marcus, and Felix Strömberg. "Effektivisering av produktionsplaneringsprocessen inom ETO med hjälp av regressionsanalys : En fallstudie om produktionsplanering och dess påverkan på ett ETO-företag." Thesis, Uppsala universitet, Institutionen för samhällsbyggnad och industriell teknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-444855.
Full textNance, William Stuart. "Forgotten Glory - Us Corps Cavalry in the ETO." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc500140/.
Full textAnand, Alagamanna Aravindh, and Simarjit Singh Juneja. "Man-Hour Estimations in ETO : A case study involving the use of regression to estimate man-hours in an ETO environment." Thesis, Uppsala universitet, Industriell teknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422186.
Full textCharbeau, Lidwine. "Inégalités de carrières entre hommes et femmes. Une approche par les conventions d'évaluation. Analyse des trajectoires professionnelles des cadres et ETAM chez un constructeur automobile." Thesis, Paris 10, 2009. http://www.theses.fr/2009PA100184.
Full textRather than reducing gender inequality with a problem of choice of incentives or pure discrimination, we propose to examine this phenomenon through the issue of labour quality. The assessment of labour quality is not just a simple coordination of actors around a selection criterion; it mobilizes a collective and consensual representation of “skilled” labourer, i.e. a quality convention. A firm is crossed by a plurality of quality conventions. We hypothesize that mobilization of some of them explains horizontal and vertical segregation (glass ceiling) by gender within organisation. An econometric study of the progression of managers and employees in a car manufacturer is proposed. This study helps us to isolate the determinants of career and assess their impact on the career paths of men and women. A qualitative interview study refines our exploration of evaluation methods and helps us to understand how business processes, apparently neutral, proved ultimately detrimental to women. These findings argue for a more practical purpose of evaluation in the diagnosis of occupational inequality. They also support the strategy of mainstreaming advocated recently by the EU and French government: to improve their efficiency, gender politics should promote forms of regulation closer to business reality
Sharrett-Field, Lynda. "SOMATIC INJURY PRECEDES DISTAL ATROPHY FOLLOWING EXCITOTOXIC HIPPOCAMPAL INSULT." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_theses/70.
Full textSalat, Daniela. "Charakterisierung der Rolle von ETO und AML1/ETO als SHARP interagierende Proteine bei der RBP-Jkappa/SHARP vermittelten Transkriptionskontrolle von Notch-Zielgenen." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-65481.
Full textSørbø, Guri Karoline, and Marianne Hønsi. "Vertical Solution for ETO Companies Using Microsoft Dynamics AX." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for bygg, anlegg og transport, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-26329.
Full textReid, Iain R. "Knowledge sharing in engineer-to-order (ETO) manufacturing enterprises." Thesis, Sheffield Hallam University, 2007. http://shura.shu.ac.uk/20271/.
Full textZhang, Bin. "Development of the Advanced Emitter Turn-Off (ETO) Thyristor." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/26095.
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Bassey, Michael Etim. "Economic viability of a floating gas-to-liquids (GTL) plant / Bassey, Michael Etim." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1577.
Full textPerez, Raphael dos Santos Miguelez. "O etos de Akihito: uma análise discursiva de alocuções do Imperador do Japão." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6122.
Full textAfter the Second World War, the Emperor of Japan lost his sovereignty and became symbol of the nation and of the unity of the Japanese people, according to the Constitution promulgated in 1947, being his functions basically ceremonials and diplomatics. Thinking of this Emperor as symbol and of the future of the imperial institution in Japan, the present dissertation tried to analyze what image Emperor Akihito creates of himself through his allocutions. Such allocutions are available on Imperial Household Agencys website in both Japanese and English. Therefore, considering that the availability of the texts in Japanese predicates Japanese coenunciators and that of the texts in English predicates the international community as coenunciators, the images created in both cases were analyzed, searching for signs of possible differences in the creation of the ethos of Akihito in both versions of his allocutions. Furthermore, one also tried to think the power relations, according to Foucault (1995, 2010), in the research corpus. For theoretical basis, concepts of the enunciative Discourse Analysis were used, more specifically the concept of ethos in Maingueneaus view (1997, 2011b). The collected material of analysis comprehends press conferences occurred in the occasion of celebrations for ten and twenty years of the enthronement of Akihito, in the years of 1999 and 2009, respectively. The methodology of research consisted in analyzing in a comparative way the texts in Japanese with the ones in English, focusing the occurrences of the Japanese verb omou, which expresses sentiment and judgment, recurrent in the Emperors allocutions. One has also analyzed the occurrences of deontic modalities in both versions of the text, considering that their few occurrences also contribute to think the Emperors image. As a result, significative differences between the two versions of the allocutions were observed. The ethos of Akihito in the allocutions in Japanese suggests an emperor that is friend and closer to the people, with a soft and moderate tone, in a way that creates identification between people and him. The ethos apprehended in the English version, on the other hand, suggests an Emperor who is stronger in his convictions, sometimes emphasizing more his feelings and opinions, sometimes less, leading to some westernization of his image. Thinking in terms of power relation, which characterize control and disclosure, one has also concluded that, being Japan the biggest capitalist ally in the East and its Emperor, symbolic representative of this country, it seems relevant that his allocutions are available in such a way that it becomes possible for the international community to exercise continuous control, ensuring the capitalist order
Hulst, Timmy. "Konsultanvändning i offentlig sektor : En kvalitativ studie av konsultanvändnings effekt på offentligt etos." Thesis, Malmö universitet, Institutionen för globala politiska studier (GPS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-45263.
Full textSEDRAN, MARIE ALLYSON. "BIODEGRADATION OF BTEX AND EtOH IN AN AEROBIC CONTINUOUS FLOW POROUS POT REACTOR." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1024933311.
Full textEl, Hayek Lars. "Vårt offentliga etos : En studie av två kommunala bostadsbolag utifrån Demokrati- och Ekonomivärden." Thesis, Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-34594.
Full textBerthelot, Charlotte. "Les endophytes bruns septés dans les sols pollués aux éléments traces métalliques (ETM) : caractérisation, effet sur les plantes et mécanismes de tolérance aux ETM." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0024/document.
Full textPhytomanagement is a handling method of contaminated sites based on the ability of plants to sequester pollutants. Fungi could favor plant growth in contaminated sites but were far less studied in the context of phytomanagement. Dark septate endophytes (DSE) were reported to improve plant tolerance against metallic trace elements (TE). The present work is part of the LORVER project and aims to understand the “plant-DSE-TE”. DSE were isolated from poplar roots growing on TE-contaminated soils and characterized. They belong to Leptodontidium, Phialophora, Cadophora and Phialocephala genera. Three strains were inoculated to birch and poplar in TE-contaminated soils. Leptodontidium sp. improved plant growth with an increase in chlorophyll, P and K concentrations, whereas Cadophora sp. decreased Cd concentration in shoots of birch. Then, Cadophora sp. Fe06, was used with an endomycorrhizal fungus, to co-inoculate ryegrass in a TE-polluted soil. The co-inoculation leads to the decrease of Cd concentration in shoots. Finally, the mechanisms involved in TE-tolerance by DSE were studied through the screening of a library of Leptondontidium sp. insertional random-mutants and an evaluation of the role of melanin against TE stress. The present work highlights the complexity of the interactions between DSE and plants under TE stress. These interactions were influenced by different parameters including plant species, DSE strains, and soil properties. Nevertheless, the ability of DSE to colonize a broad spectrum of plants in different soils and to promote plant growth, suggest that DSE could represent a substantial benefit for the fungus-assisted phytomanagement of polluted soils
Hildebrand, Daniela. "Strukturfunktionsanalyse des Translokationsprodukts AML1-ETO zur Entwicklung gezielter therapeutischer Ansätze." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965620751.
Full textZubikarai, Iturralde Nerea. "Lean management´s impact on lead time of ETO processes." Thesis, Tekniska Högskolan, Jönköping University, JTH, Industriell produktutveckling, produktion och design, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-50590.
Full textTetzlaff, Anke. "Coal fire quantification using ASTER, ETM and BIRD satellite instrument data." Diss., [S.l.] : [s.n.], 2004. http://edoc.ub.uni-muenchen.de/archive/00004398.
Full textKoloskov, Gleb. "Methodology and uncertainty in ET estimate from Landsat-7 ETM+ imagery." Thesis, University of Southampton, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582652.
Full textZhong, Yiming. "EFFECT OF INCREASED HOXB4 OR AML1-ETO ON HUMAN MEGAKARYOCYTIC DEVELOPMENT." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1284492259.
Full textGriesinger, Andrea. "The role of THPO/MPL signaling in AML1-ETO self-renewal." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1321969049.
Full textJohansson, Emelie. "Pinocchio och diskokulan : Debatter kring offentlig konst." Thesis, Linnaeus University, School of Cultural Sciences, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-5495.
Full textI uppsatsen undersöks två debatter kring offentlig konst. Debatterna behandlar skulpturerna Walking to Borås av Jim Dine uppförd i Borås 2008 samt Spegelbollen av Inges Idee som kommer att placeras i Växjö under 2010. Jag har valt att fokusera på diskussioner i ämnet som har förts i form av kommentarer på nätartiklar i de största lokaltidningarna.
Debatterna analyseras utifrån Norman Faircloughs kritiska diskursanalys och teoretiseras med hjälp av bland annat Pragskolans kommunikationsmodell. Uppsatsen behandlar hur olika parter i debatten ser på varandra samt vad diskussionerna har rört sig om.
Syrjäläinen, Sebastian, and Matilda Runnerstam. "Bibliotekets neutrala roll och demokratiska etos : Folkbibliotekarier om inköp och urval av politiskt kontroversiellt material." Thesis, Linnéuniversitetet, Institutionen för kulturvetenskaper (KV), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-89029.
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