Academic literature on the topic 'Etoposide – Synthesis'

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Journal articles on the topic "Etoposide – Synthesis"

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Saulnier, Mark G., David R. Langley, John F. Kadow, et al. "Synthesis of etoposide phosphate, BMY-40481: A water-soluble clinically active prodrug of etoposide." Bioorganic & Medicinal Chemistry Letters 4, no. 21 (1994): 2567–72. http://dx.doi.org/10.1016/s0960-894x(01)80285-7.

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Bertounesque, Emmanuel, Philippe Meresse, Claude Monneret, and Jean-Claude Florent. "Synthetic approach to condensed heterocyclic analogues from etoposide revisited. Synthesis of A-ring pyridazine etoposide." Tetrahedron Letters 48, no. 33 (2007): 5781–84. http://dx.doi.org/10.1016/j.tetlet.2007.06.105.

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3

Wrasidlo, Wolf, Ulrike Schröder, Kathrin Bernt, et al. "Synthesis, Hydrolytic Activation and Cytotoxicity of Etoposide Prodrugs." Bioorganic & Medicinal Chemistry Letters 12, no. 4 (2002): 557–60. http://dx.doi.org/10.1016/s0960-894x(01)00801-0.

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4

Kasperek, Cynthia, and Curtis D. Black. "Two Cases of Suspected Immunologic-Based Hypersensitivity Reactions to Etoposide Therapy." Annals of Pharmacotherapy 26, no. 10 (1992): 1227–30. http://dx.doi.org/10.1177/106002809202601005.

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OBJECTIVE: To report two cases of suspected immunologic-based hypersensitivity reactions to etoposide therapy. DATA SYNTHESIS: Two cases are presented that differ from the majority of reported hypersensitivity reactions to etoposide. One patient, who tolerated etoposide during his first three-day chemotherapeutic dosage regimen, developed a hypersensitivity reaction to etoposide upon re-exposure to the drug during the first day of a subsequent three-day cycle. Another patient experienced a hypotensive episode on the first day of an initial three-day regimen, which did not recur on the two subs
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5

STEFANELLI, Claudio, Francesca BONAVITA, Ivana STANIC, et al. "Inhibition of etoposide-induced apoptosis with peptide aldehyde inhibitors of proteasome." Biochemical Journal 332, no. 3 (1998): 661–65. http://dx.doi.org/10.1042/bj3320661.

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Recent investigations have indicated the involvement of proteasome in programmed cell death. The present studies show that although peptide aldehyde inhibitors of proteasome are by themselves weak inducers of apoptosis, they inhibit the apoptotic effect of the anticancer drug etoposide in rat thymocytes. Acetyl-Leu-Leu-norvalinal (LLnV-al) and other related peptide aldehydes inhibited the increase in caspase activity and DNA fragmentation that followed treatment with etoposide and their effect was related to their potency as proteasome inhibitors. To inhibit etoposide-induced apoptosis, LLnV-a
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Kandemiş, Emine, Sara Alkhatib, Barış Sergi, and Gülay Bulut. "Effect of Etoposide Treatment on ERG Transfected H358 Cell Line." Proceedings 2, no. 25 (2018): 1589. http://dx.doi.org/10.3390/proceedings2251589.

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Lung cancer is listed as the most fatal type of cancer around the world. ERG, a transcription factor, is an ETS family member protein. It is involved in Epithelial Mesenchymal Transition (EMT), metastasis and DNA repair defects. Etoposide is a chemotherapeutic agent used in treatment of a variety of different cancer types, including lung cancer. Moreover, Etoposide has been tested alone and in combination with other drugs in order to inhibit DNA synthesis and exhibit antitumor activity. The purpose of this study is to examine the effect of Etoposide treatment on ERG transfected non-small cell
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7

Kadow, John F., Min Min Tun, Alfred R. Crosswell, William C. Rose, Dolatrai M. Vyas, and Terrence W. Doyle. "Synthesis and antileukemic activity of etoposide a-ring analogs." Bioorganic & Medicinal Chemistry Letters 2, no. 1 (1992): 17–22. http://dx.doi.org/10.1016/s0960-894x(00)80646-0.

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Hasinoff, Brian B., Gaik-Lean Chee, Billy W. Day, et al. "Synthesis and Biological Activity of a Photoaffinity Etoposide Probe." Bioorganic & Medicinal Chemistry 9, no. 7 (2001): 1765–71. http://dx.doi.org/10.1016/s0968-0896(01)00102-x.

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Kadow, J. F., D. M. Vyas, and T. W. Doyle. "Synthesis of etoposide lactam via a mitsunobu reaction sequence." Tetrahedron Letters 30, no. 25 (1989): 3299–302. http://dx.doi.org/10.1016/s0040-4039(00)99226-8.

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Saulnier, Mark G., Karen L. LeBoulluec, Danny P. C. McGee, Byron H. Long, Alfred R. Crosswell, and Dolatrai M. Vyas. "Synthesis and biological activity of 3′,4′,5′-trihydroxy etoposide." Bioorganic & Medicinal Chemistry Letters 3, no. 8 (1993): 1619–24. http://dx.doi.org/10.1016/s0960-894x(00)80029-3.

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Dissertations / Theses on the topic "Etoposide – Synthesis"

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Palaty, Jan. "Oxidative coupling of dibenzylbutanolides catalyzed by plant cell culture extracts." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29710.

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This thesis aims to develop a new and inexpensive synthetic route to the anti-cancer drug etoposide (6) via 4'-demethylpodophyllotoxin (4) or 4'-demethylepipodophyllotoxin (5) involving the oxidative coupling of a dibenzylbutanolide catalyzed by a cell-free extract (CFE) from plant cell culture. This step was studied in depth using the Catharanthus roseus CFE-catalyzed biotransformation of frans-2-(3,5-dimethoxy-4-hydroxybenzyl)-3-(3-hydroxy-4-methoxybenzyl)butanolide (58) to 1-(3,5-dimethoxy-4-hydroxyphenyl)-6-hydroxy-3-hydroxymethyl-7-methoxy-1,2,3,4-tetrahydro-2-naphthoic acid γ lactone (5
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Freed, James C. "The synthesis of C-2 substituted analogues of podophyllotoxin and etoposide." Thesis, University of Ottawa (Canada), 1987. http://hdl.handle.net/10393/5404.

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Stoynov, Nikolay Mintchev. "Studies with plant cell cultures and synthetic chemistry, routes to etoposide." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0025/NQ38984.pdf.

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DALEY, LAURENT. "Synthese d'amino-desoxysucres hemisynthese d'analogues de l'etoposide." Paris 5, 1995. http://www.theses.fr/1995PA05P630.

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Conference papers on the topic "Etoposide – Synthesis"

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Hasinoff, Brian B. "Abstract 4575: Structure-based design, synthesis and biological testing of highly potent semi-synthetic epipodophyllotoxin-derived hybrid etoposide analogs." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4575.

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