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Carouge, Élisa. "Récepteur MET et fusions ETS : co-acteurs dans la progression du cancer de la prostate." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2024/2024ULILS005.pdf.
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Le cancer de la prostate (CaP) a l'incidence la plus élevée parmi les cancers masculins dans les pays européens et américains. Dans les stades avancés de la maladie, le développement des métastases (osseuses dans 80% des cas) entraîne un taux de mortalité important. Le récepteur MET et les fusions de gènes ETS avec un promoteur hormono-dépendant sont des acteurs importants dans la progression du cancer de la prostate. Parmi les membres de la famille de facteurs de transcription ETS, ERG est retrouvé dans 60% des cas des fusions et ETV1 dans 10% des cas. MET est un récepteur à activité tyrosine kinase exprimé dans les stades avancés de la maladie, dans les tumeurs hormono-résistantes et les métastases osseuses. Les fusions ERG et ETV1 sont retrouvées tout au long de la maladie, allant des stades d'initiation jusqu'aux stades métastatiques. De façon intéressante, il existe de nombreux liens fonctionnels entre MET et ERG/ETV1 suggérant leur appartenance à la même voie de régulation. Le but de notre étude est de comprendre le rôle individuel du récepteur MET et des fusions ETS ainsi que leur collaboration dans la progression du CaP.Pour ce faire, nous avons mis en place des modèles cellulaires de CaP hormono-indépendants dans lesquels l'expression et l'activité du récepteur MET sont effectives et pour lesquels une surexpression de ERG ou ETV1 a été induite via une infection rétrovirale. Ces modèles ont été utilisés pour réaliser des tests phénotypiques de prolifération, migration ou encore invasion, une analyse transcriptomique comparative (RNAseq) et des tests in vivo chez des souris humanisées exprimant l'HGF humain.Les résultats que nous avons obtenus montrent que les facteurs de transcription ERG et ETV1 induisent des capacités migratoires et invasives plus importantes in vitro et que l'activation de la voie de signalisation du récepteur amplifie les effets. In vivo, ERG et ETV1 entraînent des volumes tumoraux plus importants après injection des cellules en sous-cutanée et l'application d'un traitement par un inhibiteur spécifique de MET réverse ces effets. Finalement, la réalisation d'une analyse transcriptomique, comparant les différents modèles, a permis d'identifier des gènes différentiellement exprimés selon la surexpression de ERG, de ETV1 et/ou de l'activation de la voie MET, gènes cibles signature pouvant potentiellement être impliqués dans la progression tumorale.Ainsi, les données obtenues montrent pour la première fois une collaboration entre le récepteur MET et les facteurs ERG/ETV1 pour induire des caractéristiques plus agressives dans des modèles de CaP. A terme, le projet vise à identifier des signatures moléculaires de cette coopération afin de mettre en lumière des outils de pronostic, diagnostic ou encore de thérapie ciblée<br>Prostate cancer (PCa) has the highest incidence of all male cancers in Europe and the USA. In the advanced stages of the disease, the development of metastases (bone metastases in 80% of cases) leads to a high mortality rate. MET receptor and ETS gene fusions with a hormone-dependent promoter are important actors in the progression of prostate cancer. Among the members of the ETS family of transcription factors, ERG is found in 60% of fusions and ETV1 in 10%. MET is a tyrosine kinase receptor expressed in the advanced stages of the disease, in hormone-resistant tumours and in bone metastases. ERG and ETV1 fusions are found throughout the disease, from initiation to metastatic stages. Interestingly, there are many functional links between MET and ERG/ETV1, suggesting that they belong to the same regulatory pathway. The aim of our study is to understand the individual roles of MET receptor and ETS fusions and their collaboration in PCa progression.To this end, we built hormone-independent CaP cellular models in which MET receptor expression and activity are effective and ERG or ETV1 overexpression has been induced via retroviral infection. These models were used to perform phenotypic tests of proliferation, migration and invasion, comparative transcriptomic analysis (RNAseq) and in vivo tests in humanised mice expressing human HGF. The results we obtained show that the transcription factors ERG and ETV1 induce greater migratory and invasive capacities in vitro and that activation of the receptor signalling pathway amplifies the effects. In vivo, ERG and ETV1 induce larger tumour volumes after subcutaneous injection of the cells, and treatment with a specific MET inhibitor reverses these effects. Finally, a transcriptomic analysis comparing the different models, permits to identify genes differentially expressed according to overexpression of ERG, ETV1 and/or activation of MET pathway, signature target genes potentially involved in tumour progression.The data obtained show, for the first time, a collaboration between MET receptor and ERG/ETV1 factors to induce more aggressive characteristics in PCa models. The project aims to identify the molecular signatures of this cooperation in order to highlight prognostic, diagnostic and targeted therapy tools
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Hughes, Katelyn. "Gene fusions in cancer: Classification of fusion events and regulation patterns of fusion pathway neighbors." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-theses/764.
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Cancer is a leading cause of death worldwide, resulting in an estimated 1.6 million mortalities and 600,000 new cases in the US alone in 2015. Gene fusions, hybrid genes formed from two originally separated genes, are known drivers of cancer. However, gene fusions have also been found in healthy cells due to routine errors in replication. This project aims to understand the role of gene fusion in cancer. Specifically, we seek to achieve two goals. First, we would like to develop a computational method that predicts if a gene fusion event is associated with the cancer or healthy sample. Second, we would like to use this information to determine and characterize molecular mechanisms behind the gene fusion events. Recent studies have attempted to address these problems, but without explicit consideration of the fact that there are overlapping fusion events in both cancer and healthy cells. Here, we address this problem using FUsion Enriched Learning of CANcer Mutations (FUELCAN), a semi-supervised model, which classifies all overlapping fusion events as unlabeled to start. The model is trained using the known cancer and healthy samples and tested using the unlabeled dataset. Unlabeled data is classified as associated with healthy or cancer samples and the top 20 data points are put back into the training set. The process continues until all have been appropriately classified. Three datasets were analyzed from Acute Lymphoblastic Leukemia (ALL), breast cancer and colorectal cancer. We obtained similar results for both supervised and semi-supervised classification. To improve our model, we assessed the functional landscape of gene fusion events and observed that the pathway neighbors of both gene fusion partners are differentially expressed in each cancer dataset. The significant neighbors are also shown to have direct connections to cancer pathways and functions, indicating that these gene fusions are important for cancer development. Future directions include applying the acquired transcriptomic knowledge to our machine learning algorithm, counting transcription factors and kinases within the gene fusion events and their neighbors and assessing the differences between upstream and downstream effects within the pathway neighbors.
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Zartova, Irina. "Mesonic fusion - pion and eta meson production in light ion nuclear fusion reactions." Doctoral thesis, Stockholms universitet, Fysikum, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-39875.
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The present thesis describes two experiments performed in the storage ring CELSIUS at The Svedberg Laboratory in Uppsala. In the first experiment the importance of three - nucleon clustering in the six - nucelon system was investigated. The total cross section for the production of the ground state and the 3.56 MeV second excited state of 6Li in the 3He(3He,6Li)π+ reaction has been measured at two beam energies, 261.1 and 262.5 MeV, corresponding to center - of - mass energies 1.2 and 1.9 MeV above the production threshold for the 3.56 MeV state. For the ground state the result was 347 ± 84 ± 42 and 92 ± 84 ± 11 nb respectively. The result for the 3.56 MeV state, 104 ± 23 ± 12 and 56 ± 35 ± 7 nb respectively, is compared to the result of a previous study where the 3.56 MeV state was populated in the d(4He,6Li)π0 reaction. In the second experiment a clean sample of 5×105 eta mesons was prepared by means of the d(p,3He)η reaction. Eta production was tagged by the precise determination of the kinetic energy of the associated 3He ions. In the subsequent decay of eta mesons, channels with lepton - anti - lepton pairs were studied in the WASA detector. In a separate study properties of the WASA deuterium pellet target were investigated and in particular the effects on the beam of the beam - target interactions. In both sets of experiments the fused nuclear system was detected by means of a zero - degree spectrometer with a semiconductor detector telescope. Choosing the detectors to match the rather different requirements, precise information regarding the identity and the momentum of the detected ions could be obtained in both cases.
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Bisset, Louise Clair. "Fluorescence of a DNA-binding protein." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320129.
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White, David Maurice. "Pedagogical Fusion." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd/993.
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During the five semesters that I have been at VCU I have learned a great deal from the courses that I have been enrolled in but I have learned the most through my experiences as a Teaching Assistant. These experiences have been so valuable because of the wide range of subject areas in which I have been involved and the diverse instructors that I have assisted. Although I hesitate to use the word "problem" I feel that there is a tendency in teacher training for a student to latch onto one professor and model their teaching practices after that one mentor. While this is not always a bad thing I feel that it can lead some students down a dead-end path of self-exploration and individualization of their personal teaching style. I feel that I have been given a rare and invaluable opportunity in that I have been permitted to assist so many different teachers in such a wide array of subjects. In this thesis, I propose to examine the widely varied experiences that I have had here at VCU as a Teacher and Teaching Assistant. I will look at the teaching styles that I have witnessed, the methodologies and approaches of each course, and most importantly I will put forth my personal teaching philosophy that I have developed from my experiences here at VCU.
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Leclercq, Guillaume. "L'imposition directe des fusions intracommunautaires dans lesquelles une société française à l'IS est impliquée." Poitiers, 2000. http://www.theses.fr/2000POIT3023.
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BOUREUX, ANTHONY. "Etude des proprietes oncogeniques des proteines de fusion resultant de translocations chromosomiques impliquant des membres de la famille ets." Paris 11, 1999. http://www.theses.fr/1999PA112063.
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Les membres de la famille ets sont des facteurs de transcription impliques dans differents processus oncogeniques chez l'homme. Le travail de cette these concerne l'etude des proprietes de deux types de proteines de fusion impliquant des membres de la famille ets. Le premier aspect de ce travail a consiste a etudier les proprietes transactivatrices et transformantes de la proteine ews-fli1 caracteristique des tumeurs d'ewing. L'etude du domaine ews de ews-fli1 permet de mettre en evidence plusieurs correlations entre ces deux proprietes. De plus, l'analyse de differents mutants de la region fli1 et ews-fli1 montre que l'association du domaine ets et du domaine carboxy-terminal de fli1 est requise pour les proprietes transformantes de ews-fli1. Ceci semble suggerer que la transformation cellulaire par ews-fli1 soit dependante de cooperations intra-moleculaires et inter-moleculaires avec d'autres facteurs de transcription. Le deuxieme aspect concerne l'etude des proprietes fonctionnelles des proteines de fusion, impliquees dans differentes leucemies et dans lesquelles tel est fusionnee au pdgfr ou a jak2. La proteine tel-jak2, recemment identifiee, presente les memes proprietes que la proteine tel-pdgfr. Elles forment, in vivo, des homo-oligomeres, qui permet l'activation constitutive de l'activite tyrosine kinase intrinseque de jak2 ou de pdgfr. De plus, ces proteines permettent la survie et la proliferation des cellules baf/3 de maniere independante de l'interleukine 3. L'analyse des voies de signalisation dans les cellules baf/3 exprimant les proteines de fusion tel-jak2 ou tel-pdgfr montre une activation constitutive de la proteine kinase jnk1. Cependant, cette activation semble requise seulement pour la proliferation des cellules baf/3 sous controle de la proteine tel-pdgfr. L'ensemble de ces resultats permet de comprendre et de mieux apprehender le mecanisme d'action des proteines de fusions impliquant des proteines ets.
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Lowden, Mia Rochelle Ahmed Shawn. "Genesis of end-to-end chromosome fusions." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2227.
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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Jun. 26, 2009). "... in partial fulfillment of requirements for the degree of Doctor of Philosophy in the Department of Biology." Discipline: Biology; Department/School: Biology.
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Pradhan, Pushkar S. "Multiresolution based, multisensor, multispectral image fusion." Diss., Mississippi State : Mississippi State University, 2005. http://library.msstate.edu/etd/show.asp?etd=etd-07082005-140541.
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Xu, Jin. "Understanding the molecular determinants of prostate tumorigenesis: androgen receptor's requirement for histone deacetylases and the role of recurrent ETS fusion." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1563274481&sid=5&Fmt=2&clientId=48051&RQT=309&VName=PQD.
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Meyer, David Christopher. "Universal deformation rings and fusion." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1883.
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This thesis is on the representation theory of finite groups. Specifically, it is about finding connections between fusion and universal deformation rings.
Two elements of a subgroup N of a finite group Γ are said to be fused if they are conjugate in Γ, but not in N. The study of fusion arises in trying to relate the local structure of Γ (for example, its subgroups and their embeddings) to the global structure of Γ (for example, its normal subgroups, quotient groups, conjugacy classes). Fusion is also important to understand the representation theory of Γ (for example, through the formula for the induction of a character from N to Γ).
Universal deformation rings of irreducible mod p representations of Γcan be viewed as providing a universal generalization of the Brauer character theory of these mod p representations of Γ.
It is the aim of this thesis to connect fusion to this universal generalization by considering the case when Γ is an extension of a finite group G of order prime to p by an elementary abelian p-group N of rank 2. We obtain a complete answer in the case when G is a dihedral group, and we also consider the case when G is abelian. On the way, we compute for many absolutely irreducible FpΓ-modules V, the cohomology groups H2(Γ,HomFp(V,V) for i = 1, 2, and also the universal deformation rings R(Γ,V).
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DeBerard, M. Scott. "Predicting Lumbar Fusion Surgery Outcomes From Presurgical Patient Variables: The Utah Lumbar Fusion Outcome Study." DigitalCommons@USU, 1998. https://digitalcommons.usu.edu/etd/6142.
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Lumbar fusion surgery is a commonly used procedure to treat severe spinal pathology and associated chronic disabling low back and leg pain. Despite the common incidence of spinal fusion surgery, few studies have examined patient outcomes or predictive correlates of this procedure. The objectives of this study were to characterize Utah workers who received lumbar fusion surgery in terms of relevant presurgical and outcome variables and to identify presurgical correlates of patient outcomes. An archival prospective research design was utilized consisting of a retrospective medical chart review and a postsurgical telephone outcome survey.
Subjects were 203 workers' compensation patients from the state of Utah who have undergone spinal fusion surgery and who were at least 2 years postsurgery at time of follow-up. Outcomes were assessed for 144 of the 203 patients (71%). Presurgical measures _included demographic, work, compensation, disability, health, surgical, and physiological variables. Outcome measures included solid arthrosis, patient satisfaction, work disability status, functional disability due to back pain, and multidimensional health.
Analysis of patient outcome data revealed that solid arthrosis was achieved in 71.9% of patients. Forty-six percent of subjects felt their back/leg pain problems were worse than what they had expected following the surgery, and 42 % felt that their quality of life had not changed or worsened as a result of lumbar fusion. Twenty-eight percent of fusion patients were work disabled at follow-up. Fusion patient mean outcome scores on multidimensional health measures reflected poorer health than comparative medical patient and nonpatient norms. The most consistent presurgical correlates across outcomes were lawyer involvement, number of prior low back operations, age at injury, and household income at time of injury.
Results are compared to data from previous lumbar fusion research studies and reasons for varying findings are offered. Implications of the findings are discussed in terms of inadequate patient selection and insufficient assessment of patient outcomes in low back research studies. Limitations of the present research are discussed, including how placebo, natural history, and regression to the mean can lead to erroneous conclusions about the efficacy of lumber fusion surgery. Suggestions for improvements in low back surgery outcome research are offered.
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Amri, Mohamed-Hédi. "Fusion ensembliste de donn´ees pour la surveillance des personnes d´ependantes en habitat intelligent." Thesis, Orléans, 2015. http://www.theses.fr/2015ORLE2030/document.
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Mes travaux de recherches en thèse s’inscrivent dans le cadre du projet FUIE-monitorâge. L’objectif du projet, réunissant de nombreux partenaires industriels et universitaires, est d’améliorer la prise en charge individualisée et la sécurité du résident dans les établissements d’hébergement pour personnes âgées dépendantes(EHPAD). Dans ce travail, nous avons élaboré une méthode de fusion de données multimodales issues des différents capteurs installés dans un smart home. Ces informations sont utilisées pour la localisation intérieure des personnes afin de surveiller leurs activités journalières. Généralement, les mesures issues des capteurs sont soumises à des incertitudes. Dans nos travaux, ces erreurs sont supposées inconnues mais bornées. En tenant compte de cette hypothèse, une méthode de résolution d’un problème d’estimation d’état est élaborée en se basant sur des calculs ensemblistes. Notre algorithme de filtrage ensembliste comporte deux étapes. La première, dite de prédiction, est basée sur l’utilisation d’un modèle de marche aléatoire avec des hypothèses minimales (vitesse de déplacement maximale) pour prédire la zone où se trouve la personne. La deuxième étape, dite de correction, consiste à utiliser la mesure pour affiner cette zone. Cette étape utilise une technique de propagation de contraintes relâchée, q-relaxed intersection, pour permettre une meilleure robustesse par rapport aux données aberrantes. Notre algorithme est capable de quantifier, par un intervalle, l’incertitude commise sur les positions de cibles en mouvement tout en détectant les défauts de capteurs<br>Our research work is a part of the project FUI 14 FEDER Collectivités E-monitor’âge. This project takes place within the framework of Ambient Assisted Living (AAL) which aims to improve the safety and the comfort of elderly people living in smart nursing homes. This work aims to monitor the activities of elderly persons using information from different sensors. The ADL (Activities of Daily Living) are used to evaluate the ability of the person to perform on their own a selection of the activities which are essential for an independent living in the everyday life. Generally, process knowledge and measurements coming from sensors are prone to indeterminable noise. In our work, we suppose that these errors are unknown but bounded. Taking into account this hypothesis, we show how to solve the estimation issue using set-membership computations techniques. Our algorithm, based on set-membership approach, consists of two steps. The prediction step, based on the use of a random walk mobility with minimum assumptions (maximum speed of moving), employs the previous state estimate to provide the prediction zone where the person may be located. The correction step uses the informations coming from the sensors to refine this predicted zone. This step uses a relaxed constraints propagation technique, q-relaxed intersection, to deal with faulty measurements. This proposed method allows us to compute the uncertainty domain for the reconstructed localization of moving targets as dealing with outliers
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Nguyen, Long Bao. "Fusions of character tables and schur rings of dihedral groups /." Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2443.pdf.
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Curfs, Garrit Thomas. "Experiment as rhetoric in the cold fusion controversy." Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-03142009-040600/.
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Abyarjoo, Fatemeh. "Sensor Fusion for Effective Hand Motion Detection." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2215.
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Litant, Thomas F. "The fusion and integration of virtual sensors." W&M ScholarWorks, 2002. https://scholarworks.wm.edu/etd/1539623397.
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There are numerous sensors from which to choose when designing a mobile robot: ultrasonic, infrared, radar, or laser range finders, video, collision detectors, or beacon based systems such as the Global Positioning System. In order to meet the need for reliability, accuracy, and fault tolerance, mobile robot designers often place multiple sensors on the same platform, or combine sensor data from multiple platforms. The combination of the data from multiple sensors to improve reliability, accuracy, and fault tolerance is termed Sensor Fusion.;The types of robotic sensors are as varied as the properties of the environment that need to be sensed. to reduce the complexity of system software, Roboticists have found it highly desirable to adopt a common interface between each type of sensor and the system responsible for fusing the information. The process of abstracting the essential properties of a sensor is called Sensor Virtualization.;Sensor virtualization to date has focused on abstracting the properties shared by sensors of the same type. The approach taken by T. Henderson is simply to expose to the fusion system only the data from the sensor, along with a textual label describing the sensor. We extend Henderson's work in the following manner. First, we encapsulate both the fusion algorithm and the interface layer in the virtual sensor. This allows us to build multi-tiered virtual sensor hierarchies. Secondly, we show how common fusion algorithms can be encapsulated in the virtual sensor, facilitating the integration and replacement of both physical and virtual sensors. Finally, we provide a physical proof of concept using monostatic sonars, vector sonars, and a laser range-finder.
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Lefebvre, Grégoire. "Sélection et fusion de signatures visuelles parcimonieuses : application à la classification d'images naturelles." Bordeaux 2, 2007. http://www.theses.fr/2007BOR21463.
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Les travaux effectués dans le cadre de cette thèse portent sur la classification automatique des images numériques en fonction de leur contenu visuel. L'objectif est d'assigner à une image de test une identité parmi celles d'un ensemble de catégories connues. Pour cela, on cherche à extraire un ensemble de signatures visuelles parcimonieuses, qui lui soit spécifique, puis à sélectionner et structurer l'information discriminante, avant de proposer une classification adaptée à leur nature et à l'application visée. De nombreuses méthodes ont été proposées dans la littérature pour décrire le contenu visuel des images. Parmi les plus efficaces, on compte les techniques d'extraction de points d'intérêt et de descriptions des singularités locales. Ce travail reprend ce principe et propose de nouvelles techniques de sélection et de fusion de signatures locales, basées sur l'analyse de cartes de neurones auto-organisatrices. Un nouveau support de l'information du contenu visuel est alors proposé comme étant l'activation d'un modèle neuronal multimodal. Les méthodes proposées permettent de se focaliser sur les éléments spécifiques d'une catégorie, vis-à-vis des autres catégories en compétition. Elles permettent ainsi une certaine robustesse aux changements de prises de vue, aux variations d'illumination et aux occultations partielles. Les techniques proposées sont évaluées et comparées aux approches usuelles selon des protocoles expérimentaux rigoureux. Les résultats ainsi obtenus montrent les très bonnes performances des approches introduites dans les domaines de la classification d'images, de la reconnaissance de visages et du filtrage de contenus tendancieux<br>This thesis is concerned with automatic classification. The objective is to assign an identity to a test image among a set of known category. The underlying approach aim at extracting a specific set of parsimonious visual signatures, then selecting and melting discriminative information, before designing a classification scheme adapted to the context. Many methods have been proposed in order to describe visual content. One of the most effective is based on points of interest extraction and local singularity description. In the thesis, this principle is used to define next local signature and combination, based on self-organizing neural maps. A novel image information support s then proposed, being the activation of a multimodal neural model. The proposed methods focus on specific elements of one image class versus the other categories. It permits robustness to viewpoint changes, illumination variations and partial occlusions. The proposed techniques are evaluated and compared to usual methods using various international databases. These experiments show the effectiveness of the proposed approaches, in particular, in the domains of image classification, face recognition and objectionable content exclusion
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Merker, James. "Micro-autoradiographic fusion tomography." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002417.
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Rigaud, Emmanuelle. "Le processus de reconfiguration des ressources dans les fusions-acquisitions : le cas des firmes rachetées dont la marque est conservée." Paris 10, 2009. http://www.theses.fr/2009PA100034.
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La théorie des ressources s’est construite autour de la question, centrale en stratégie, de l’avantage concurrentiel. Et la difficulté de l’opérationnaliser reste une de ses principales limites. La thèse vise à améliorer l’opérationnalisation de cette théorie. Ainsi, elle étudie des situations propices à la reconfiguration des ressources, les fusions-acquisitions. Cette recherche s’intéresse aux firmes rachetées lorsque la marque est maintenue. Du fait de la fusion, ces dernières ont accès à de nouvelles ressources ou à des ressources recombinées. Ceci conduit à la question de recherche : comment s’opère la reconfiguration des ressources dans de telles situations ? La méthodologie combine analyse de cas (cinq cas étudiés) et démarche comparative. L’étude porte sur les processus de reconfiguration organisationnelle (pris comme un moyen d’accès aux reconfigurations de ressources). Ces processus combinent mutualisation (la firme rachetée dispose de meilleures ressources) et autonomie (elle se maintient en tant que marque). Des templates permettent l’analyse intra et inter-cas. Ils portent sur l’analyse des séquences et les configurations organisationnelles. Les processus à l’œuvre sont rapprochés des processus-types identifiés par Van de Ven (1992). La thèse, qui détaille la dynamique des processus complexes d’intégration, a notamment permis de mettre en évidence un phénomène peu étudié, le temps de latence suivant une fusion, ainsi que différents types de trajectoires. Nous montrons que certaines trajectoires mènent à un état d’équilibre stable entre autonomie et mutualisation, d’autres se caractérisent par un phénomène d’oscillation semblant rendre le processus interminable<br>The theory of resource-based view stems from the issue of competitive advantage, which is central to the field of strategy. As a matter of fact, the difficulty to put it into practice remains one of its main limits. This research aims to improve the ways of implementing this theory. Thus, it studies situations favorable to resources reconfiguration: mergers and acquisitions. This study mainly focuses on acquired firms whose brand is maintained. Thanks to mergers, these firms have access to either new or mixed resources. This leads to the central research question: in which way are resources being reconfigured in such situations? Five cases dealing with these situations have been analysed. As regards methodology, case analysis has been combined to a comparative approach. The study focuses on organisational reconfiguration processes (taken as a means to access resources reconfiguration). These processes combine synergy (the acquired firm benefits from more efficient resources) and autonomy (the firm's brand is maintained). Templates gathering the sequential analysis of the processes and organisational structuring, allow for the intra-case as well as for the cross-cases analysis, which relies on the process-type theory introduced by Van de Ven (1992). The thesis pays close attention to the dynamic of complex integration processes. It highlights more particularly the latency stage which follows mergers, a phenomenon which has been little studied so far, and different types of trajectories. This research demonstrates that some trajectories lead to a state balancing autonomy and synergy, while others lead to an oscillation phenomenon, to which there seems to be no end
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Cavanaugh, Andrew F. "Bayesian Information Fusion for Precision Indoor Location." Digital WPI, 2011. https://digitalcommons.wpi.edu/etd-theses/157.
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This thesis documents work which is part of the ongoing effort by the Worcester Polytechnic Institute (WPI) Precision Personnel Locator (PPL) project, to track and locate first responders in urban/indoor settings. Specifically, the project intends to produce a system which can accurately determine the floor that a person is on, as well as where on the floor that person is, with sub-meter accuracy. The system must be portable, rugged, fast to set up, and require no pre-installed infrastructure. Several recent advances have enabled us to get closer to meeting these goals: The development of Transactional Array Reconciliation Tomography(TART) algorithm, and corresponding locator hardware, as well as the integration of barometric sensors, and a new antenna deployment scheme. To fully utilize these new capabilities, a Bayesian Fusion algorithm has been designed. The goal of this thesis is to present the necessary methods for incorporating diverse sources of information, in a constructive manner, to improve the performance of the PPL system. While the conceptual methods presented within are meant to be general, the experimental results will focus on the fusion of barometric height estimates and RF data. These information sources will be processed with our existing Singular Value Array Reconciliation Tomography (σART), and the new TART algorithm, using a Bayesian Fusion algorithm to more accurately estimate indoor locations.
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Heo, Gyeongyong. "Robust kernel methods in context-dependent fusion." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0041144.
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Bidgood, Lee, and Doctors and Outlaws. "Celebration of 1970s Country-Rock-Grass Fusion." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/1063.
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A one-time celebration of the 1970s country-rock-grass fusion of Crowe, Parsons, the Rices, the Burritos, etc. View the YouTube videos below:
Part 1: https://www.youtube.com/watch?v=lbWzeKhdbus
Part 2: https://www.youtube.com/watch?v=ImrFFCPPXw4
Part 3: https://www.youtube.com/watch?v=Je5oXBpDGmU
Part 4: https://www.youtube.com/watch?v=WkNjD079QFQ
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ABURTO, ANDREA. "Caracterisation magnetique du supra conducteur et2-br dans l'etat mixte, du voisinage de la transition de fusion." Paris 11, 1998. http://www.theses.fr/1998PA112294.
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Ce memoire concerne l'etude du supraconducteur organique -(bedt-ttf)#2cun(cn)2br ou et#2-br dans l'etat mixte par des mesures magnetiques. Nous avons applique une partie de l'arsenal experimental et theorique developpe a l'occasion de l'essor des oxydes supraconducteurs a l'etude d'un compose organique moins connu : -(bedt-ttf)#2cun(cn)2br. Dans ce travail, nous avons mis en uvre trois techniques experimentales maintenant classiques dans l'etude de l'etat mixte supraconducteur : magnetometre et susceptometre alternatif a squid, susceptometre alternatif a sonde de hall, magnetometre a effet de couple. A l'aide des deux premieres, nous avons explore les energies d'activation du mouvement des lignes de flux de part et d'autre de la ligne d'irreversibilite du compose. A cette occasion, nous avons developpe l'analyse qui peut etre faite de la reponse alternative lineaire dans la phase liquide de vortex, ainsi que celle de la reponse non lineaire dans la phase vitreuse. Dans une seconde partie, nous avons cherche a mettre en evidence une signature de la transition de fusion du reseau de vortex au voisinage de la ligne d'irreversibilite, ainsi que le laissaient pressentir nos premiers resultats. Enfin, dans un dernier temps (bien que, pour des raisons pedagogiques, nous presentions ces resultats en premier), il nous a paru indispensable d'entreprendre l'etude de la dependance des proprietes supraconductrices en fonction des cyclages thermiques du compose et la mise en relation de cette dependance avec la possibilite d'introduire un desordre de maniere reversible.
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Mahmood, Nozad. "Sparse Ridge Fusion For Linear Regression." Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5986.
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For a linear regression, the traditional technique deals with a case where the number of observations n more than the number of predictor variables p (n>p). In the case n<p, the classical method fails to estimate the coefficients. A solution of this problem in the case of correlated predictors is provided in this thesis. A new regularization and variable selection is proposed under the name of Sparse Ridge Fusion (SRF). In the case of highly correlated predictor , the simulated examples and a real data show that the SRF always outperforms the lasso, elastic net, and the S-Lasso, and the results show that the SRF selects more predictor variables than the sample size n while the maximum selected variables by lasso is n size.<br>M.S.<br>Masters<br>Statistics<br>Sciences<br>Statistical Computing
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Seneker, Stephen S. "Synesthetic sensor fusion via a cross-wired artificial neural network." [Johnson City, Tenn. : East Tennessee State University], 2002. http://etd-submit.etsu.edu/etd/theses/available/etd-0403102-164937/unrestricted/SenekerS041902.pdf.
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Sun, Roy. "Pedestrian Detection Based on Data and Decision Fusion Using Stereo Vision and Thermal Imaging." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-theses/308.
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Pedestrian detection is a canonical instance of object detection that remains a popular topic of research and a key problem in computer vision due to its diverse applications. These applications have the potential to positively improve the quality of life. In recent years, the number of approaches to detecting pedestrians in monocular and binocular images has grown steadily. However, the use of multispectral imaging is still uncommon. This thesis work presents a novel approach to data and feature fusion of a multispectral imaging system for pedestrian detection. It also includes the design and building of a test rig which allows for quick data collection of real-world driving. An application of the mathematical theory of trifocal tensor is used to post process this data. This allows for pixel level data fusion across a multispectral set of data. Performance results based on commonly used SVM classification architectures are evaluated against the collected data set. Lastly, a novel cascaded SVM architecture used in both classification and detection is discussed. Performance improvements through the use of feature fusion is demonstrated.
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Natarajan, Ramkumar. "Efficient Factor Graph Fusion for Multi-robot Mapping." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-theses/1201.
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"This work presents a novel method to efficiently factorize the combination of multiple factor graphs having common variables of estimation. The fast-paced innovation in the algebraic graph theory has enabled new tools of state estimation like factor graphs. Recent factor graph formulation for Simultaneous Localization and Mapping (SLAM) like Incremental Smoothing and Mapping using the Bayes tree (ISAM2) has been very successful and garnered much attention. Variable ordering, a well-known technique in linear algebra is employed for solving the factor graph. Our primary contribution in this work is to reuse the variable ordering of the graphs being combined to find the ordering of the fused graph. In the case of mapping, multiple robots provide a great advantage over single robot by providing a faster map coverage and better estimation quality. This coupled with an inevitable increase in the number of robots around us produce a demand for faster algorithms. For example, a city full of self-driving cars could pool their observation measurements rapidly to plan a traffic free navigation. By reusing the variable ordering of the parent graphs we were able to produce an order-of-magnitude difference in the time required for solving the fused graph. We also provide a formal verification to show that the proposed strategy does not violate any of the relevant standards. A common problem in multi-robot SLAM is relative pose graph initialization to produce a globally consistent map. The other contribution addresses this by minimizing a specially formulated error function as a part of solving the factor graph. The performance is illustrated on a publicly available SuiteSparse dataset and the multi-robot AP Hill dataset."
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Perez, Ramona V. "A Charged Fusion Product Diagnostic for a Spherical Tokamak." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2233.
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Designs for future nuclear fusion power reactors rely on the ability to create a stable plasma (hot ionized gas of hydrogen isotopes) as a medium with which to sustain nuclear fusion reactions. My dissertation work involves designing, constructing, testing, installing, operating, and validating a new diagnostic for spherical tokamaks, a type of reactor test facility. Through detecting charged particles emitted from the plasma, this instrument can be used to study fusion reaction rates within the plasma and how they are affected by plasma perturbations. Quantitatively assessing nuclear fusion reaction rates at specific locations inside the plasma and as a function of time can provide valuable data that can be used to evaluate theory-based simulations related to energy transport and plasma stability.
The Proton Detector (PD), installed in the Mega Amp Spherical Tokamak (MAST) at the Culham Centre for Fusion Energy (CCFE) in Abingdon, England, was the first instru- ment to experimentally detect 3 MeV Protons and 1 MeV Tritons created from deuterium- deuterium (hydrogen isotopes) nuclear fusion reactions inside a spherical tokamak’s plasma. The PD consists of an array of particle detectors with a protective housing and the neces- sary signal conditioning electronics and readout. After several years of designing (which included simulations for detector orientations), fabricating, and testing the PD, it was installed in MAST and data were collected over a period of two months in the summer of 2013. Proton and triton rates as high as 200 kHz were measured and an initial radial profile of these fusion reaction rates inside the plasma was extracted.
These results will be compared to a complementary instrument at MAST as well as theory-based simulations and form the knowledge basis for developing a larger future in- strument. The design and performance of all instrument components (electrical, computa- tional, mechanical), and subsequent data analysis methods and results are described in this dissertation.
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Perry, Nathan C. "Fusion of the Parastrophic Matrix and Weak Cayley Table." BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/1792.
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The parastrophic matrix and Weak Cayley Tables are matrices that have close ties to the character table. Work by Ken Johnson has shown that fusion of groups induces a relationship between the character tables of the groups. In this paper we will demonstrate a similar induced relationship between the parastrophic matrices and Weak Cayley Tables of the fused groups.
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Mansourbeigi, Seyed M.-H. "Sheaf Theory as a Foundation for Heterogeneous Data Fusion." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7363.
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A major impediment to scientific progress in many fields is the inability to make sense of the huge amounts of data that have been collected via experiment or computer simulation. This dissertation provides tools to visualize, represent, and analyze the collection of sensors and data all at once in a single combinatorial geometric object. Encoding and translating heterogeneous data into common language are modeled by supporting objects. In this methodology, the behavior of the system based on the detection of noise in the system, possible failure in data exchange and recognition of the redundant or complimentary sensors are studied via some related geometric objects. Applications of the constructed methodology are described by two case studies: one from wildfire threat monitoring and the other from air traffic monitoring. Both cases are distributed (spatial and temporal) information systems. The systems deal with temporal and spatial fusion of heterogeneous data obtained from multiple sources, where the schema, availability and quality vary. The behavior of both systems is explained thoroughly in terms of the detection of the failure in the systems and the recognition of the redundant and complimentary sensors. A comparison between the methodology in this dissertation and the alternative methods is described to further verify the validity of the sheaf theory method. It is seen that the method has less computational complexity in both space and time.
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LaCaille, Rick. "Outcomes and Presurgical Correlates of Lumbar Interbody Cage Fusion." DigitalCommons@USU, 2003. https://digitalcommons.usu.edu/etd/6180.
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Rates of lumbar fusion surgery have been increasing with an estimated 192,000 procedures performed annually. However, satisfactory outcomes of lumbar fusion vary considerably and often emphasize technical success, such as arthrodesis, rather than Ill functional and quality of life outcomes. Interbody cage fusion was recently developed and touted as a superior alternative to existing lumbar fusion procedures. There is, however, a paucity of research to support these claims, particularly with regards to functional and quality of life outcomes. Moreover, predictive correlates of outcomes for interbody cage fusion have not been given adequate attention in the literature. The aims of this study were to characterize patients undergoing this new procedure, examine functional and multidimensional outcomes, and investigate the predictive efficacy of presurgical variables. A retrospective cohort research design was employed and entailed medical record reviews for presurgical data and telephone outcome surveys at least 18 months following surgery.
Seventy-three patients who had undergone lumbar interbody cage fusion were identified from the private practice of an orthopedic surgeon and the Workers' Compensation Fund of Utah. Presurgical variables coded for analysis included age at the time of surgery, severity rating of presurgical spinal pathology, smoking tobacco, depression, and pursuing litigation at the time of surgery. Of the total sample, 56 patients (76.7%) completed outcome surveys that assessed patient satisfaction, back-specific functioning, disability status, and physical and mental health functioning.
While arthrodesis was achieved for most patients (84%), almost half were dissatisfied with their current back condition. Outcomes regarding disability and functioning were mixed. Arthrodesis was only moderately associated with better outcome and for a quite limited set of measure s. Three of the five presurgical variables (tobacco use, depression, and litigation) were consistently predictive of patient outcomes.
Findings are discussed and compared to existing data on lumbar fusion procedures , and clinical implications for improved patient selection and possible interventions are highlighted. Consideration is given to the limitations of this study, such as retrospective design, no matched controls , and sample size. Directions for future research are suggested.
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Givens, Matthew. "Multiple IMU Sensor Fusion for SUAS Navigation and Photogrammetry." DigitalCommons@USU, 2019. https://digitalcommons.usu.edu/etd/7617.
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Inertial measurement units (IMUs) are devices that sense accelerations and angular rates in 3D so that vehicles and other devices can estimate their orientations, positions, and velocities. While traditionally large, heavy, and costly, using mechanical gyroscopes and stabilized platforms, the recent development of micro-electromechanical sensor (MEMS) IMUs that are small, light, and inexpensive has led to their adoption in many everyday systems such as cell phones, video game controllers, and commercial drones. MEMS IMUs, despite their advantages, have major drawbacks when it comes to accuracy and reliability. The idea of using more than one of these sensors in an array, instead of using only one, and fusing their outputs to generate an improved solution is explored in this thesis.
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Bennett, Selester. "The construction and testing of maize transcriptional fusions in yeast (Saccharomyces cerevisiae)." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-10312009-020253/.
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Ganta, Srivatsava Ranjit Acharya Rajgopal Sundaraj. "Fusion-aware privacy andwarehousing for healthcare databases." [University Park, Pa.] : Pennsylvania State University, 2009. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-3567/index.html.
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Nguyen, Long Pham Bao. "Fusion of Character Tables and Schur Rings of Dihedral Groups." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/1429.
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A finite group H is said to fuse to a finite group G if the class algebra of G is isomorphic to an S-ring over H which is a subalgebra of the class algebra of H. We will also say that G fuses from H. In this case, the classes and characters of H can fuse to give the character table of G. We investigate the case where H is the dihedral group. In many cases, G can be completely determined. In general, G can be proven to have many interesting properties. The theory is developed in terms of S-ring of Schur and Wielandt.
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Seneker, Stephen Samuel. "Synesthetic Sensor Fusion via a Cross-Wired Artificial Neural Network." Digital Commons @ East Tennessee State University, 2002. https://dc.etsu.edu/etd/673.
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The purpose of this interdisciplinary study was to examine the behavior of two artificial neural networks cross-wired based on the synesthesia cross-wiring hypothesis. Motivation for the study was derived from the study of psychology, robotics, and artificial neural networks, with perceivable application in the domain of mobile autonomous robotics where sensor fusion is a current research topic. This model of synesthetic sensor fusion does not exhibit synesthetic responses. However, it was observed that cross-wiring two independent networks does not change the functionality of the individual networks, but allows the inputs to one network to partially determine the outputs of the other network in some cases. Specifically, there are measurable influences of network A on network B, and yet network B retains its ability to respond independently.
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Perry, Nathan. "Fusion of the parastrophic matrix and Weak Cayley Table /." Diss., CLICK HERE for online access, 2009. http://contentdm.lib.byu.edu/ETD/image/etd2962.pdf.
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Washington, Nicole Leanne. "Regulation of Membrane Fusion Events During Caenorhabditis elegans Spermatogenesis." Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1405%5F1%5Fm.pdf&type=application/pdf.
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Yuth, Kenneth. "Characterizing the Phosphorylation State of Tie2 using SH2 Domain Fusion Proteins." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/275.
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The cardiovascular system develops through two distinct processes in embryogenesis: vasculogenesis, whereby the primary plexus in the heart is formed along with embryonic and extraembryonic vasculature, and angiogenesis, which begins after vasculogenesis and results in the refinement and maturation of the branched vessel system. In pathological angiogenesis, tumors expand by releasing pro-angiogenic factors in response to hypoxic conditions. The Tie receptors, Tie1 and Tie2, are receptor tyrosine kinases that are integral to angiogenic pathways. A family of Angiopoietins, Ang1-4, have been shown to act as ligands for Tie2, of which Ang1 and Ang2 are best characterized. Activation of the receptor causes dimerization and autophosphorylation, whereby adaptor proteins recognizing the phosphorylated tyrosine activate downstream signaling via their Src homology 2 (SH2) domains. Currently there are no phosphospecific antibodies for Tie2, therefore, identifying critical residues responsible for certain pathways remains difficult. In our study, we aim to use purified SH2 domains of known binding partners to Tie2 to assess the phosphorylation state of the receptor under various cellular conditions and settings, utilizing immunoprecipitation and western blotting. Unexpectedly, we found that Tie2 can bind non-specifically to nickel sepharose when the SH2 proteins were used as antibody mimetics, and was unable to be consistently precipitated in Protein A sepharose when used in conjunction with a monoclonal YFP antibody. Under the latter conditions however we were able to precipitate the SH2 protein itself. When immunoprecipitations were used with cobalt activated IMAC beads, we were able to precipitate Tie2 in overexpressed systems using the SH2 domains of Shp2 N-C and Grb2. As expected, phosphorylation of Tie2 in the presence of its orphan receptor Tie1 was attenuated compared to wild-type levels. Based upon available data, we anticipate this method as a useful tool to assess the phosphorylation state of Tie2 and its signaling pathways in the near future.
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Dinerstein, Jared. "Learning-Based Fusion for Data Deduplication: A Robust and Automated Solution." DigitalCommons@USU, 2010. https://digitalcommons.usu.edu/etd/787.
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This thesis presents two deduplication techniques that overcome the following critical and long-standing weaknesses of rule-based deduplication: (1) traditional rule-based deduplication requires significant manual tuning of the individual rules, including the selection of appropriate thresholds; (2) the accuracy of rule-based deduplication degrades when there are missing data values, significantly reducing the efficacy of the expert-defined deduplication rules.
The first technique is a novel rule-level match-score fusion algorithm that employs kernel-machine-based learning to discover the decision threshold for the overall system automatically. The second is a novel clue-level match-score fusion algorithm that addresses both Problem 1 and 2. This unique solution provides robustness against missing/incomplete record data via the selection of a best-fit support vector machine. Empirical evidence shows that the combination of these two novel solutions eliminates two critical long-standing problems in deduplication, providing accurate and robust results in a critical area of rule-based deduplication.
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Berman, Noah Chase Abramowitz Jonathan S. "Relationship between religiosity and thought action fusion a behavioral paradigm /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2900.
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Thesis (M.A.)--University of North Carolina at Chapel Hill, 2010.<br>Title from electronic title page (viewed Jun. 23, 2010). "... in partial fulfillment of the requirements for the degree of Master of Arts in the Department of Psychology Clinical Psychology." Discipline: Psychology; Department/School: Psychology.
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Francoforte, Kevin. "PARAMETER ESTIMATION USING SENSOR FUSION AND MODEL UPDATING." Master's thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4154.
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Engineers and infrastructure owners have to manage an aging civil infrastructure in the US. Engineers have the opportunity to analyze structures using finite element models (FEM), and often base their engineering decisions on the outcome of the results. Ultimately, the success of these decisions is directly related to the accuracy of the finite element model in representing the real-life structure. Improper assumptions in the model such as member properties or connections, can lead to inaccurate results. A major source of modeling error in many finite element models of existing structures is due to improper representation of the boundary conditions. In this study, it is aimed to integrate experimental and analytical concepts by means of parameter estimation, whereby the boundary condition parameters of a structure in question are determined. FEM updating is a commonly used method to determine the "as-is" condition of an existing structure. Experimental testing of the structure using static and/or dynamic measurements can be utilized to update the unknown parameters. Optimization programs are used to update the unknown parameters by minimizing the error between the analytical and experimental measurements. Through parameter estimation, unknown parameters of the structure such as stiffness, mass or support conditions can be estimated, or more appropriately, "updated", so that the updated model provides for a better representation of the actual conditions of the system. In this study, a densely instrumented laboratory test beam was used to carry-out both analytical and experimental analysis of multiple boundary condition setups. The test beam was instrumented with an array of displacement transducers, tiltmeters and accelerometers. Linear vertical springs represented the unknown boundary stiffness parameters in the numerical model of the beam. Nine different load cases were performed and static measurements were used to update the spring stiffness, while dynamic measurements and additional load cases were used to verify these updated parameters. Two different optimization programs were used to update the unknown parameters and then the results were compared. One optimization tool was developed by the author, Spreadsheet Parameter Estimation (SPE), which utilized the Solver function found in the widely available Microsoft Excel software. The other one, comprehensive MATLAB-based PARameter Identification System (PARIS) software, was developed at Tufts University. Optimization results from the two programs are presented and discussed for different boundary condition setups in this thesis. For this purpose, finite element models were updated using the static data and then these models were checked against dynamic measurements for model validation. Model parameter updating provides excellent insight into the behavior of different boundary conditions and their effect on the overall structural behavior of the system. Updated FEM using estimated parameters from both optimization software programs generally shows promising results when compared to the experimental data sets. Although the use of SPE is simple and generally straight-forward, we will see the apparent limitations when dealing with complex, non-linear support conditions. Due to the inherent error associated with experimental measurements and FEM modeling assumptions, PARIS serves as a better suited tool to perform parameter estimation. Results from SPE can be used for quick analysis of structures, and can serve as initial inputs for the more in depth PARIS models. A number of different sensor types and spatial resolution were also investigated for the possible minimum instrumentation to have an acceptable model representation in terms of model and experimental data correlation.<br>M.S.<br>Department of Civil and Environmental Engineering<br>Engineering and Computer Science<br>Civil Engineering MS
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Friis, Zachary W. "An investigation of MARFE induced H-L back transitions." Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-09072005-155104/.
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Thesis (M. S.)--Nuclear and Radiological Engineering, Georgia Institute of Technology, 2006.<br>Dr. Cassiano de Oliveira, Committee Member ; Dr. John Mandrekas, Committee Member ; Dr. Weston M. Stacey, Committee Chair. Includes bibliographical references.
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Coll, Jean-Luc. "Caractérisation de gènes dont l'expression est régulée par le pH extracellulaire chez Escherichia coli K-12 et analyse des éléments intervenant en cis ou en trans dans ce contrôle." Lyon 1, 1992. http://www.theses.fr/1992LYO10013.
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Le programme d'identification et de caracterisation des genes dont l'expression est regulee par le ph extracellulaire (phe) chez escherichia coli, a ete initie alors que seulement trois genes ph-regules avaient ete decrits, et que les mecanismes de leur regulation etaient inconnus. Afin d'identifier de nouveaux genes ph-regules, nous avons construit des souches bacteriennes portant des fusions dans des genes dont l'expression est sensible au phe (notes phm pour ph-modulated). Dans un premier temps, nous avons caracterise genetiquement in vivo les genes phm. Les resultats obtenus montrent qu'ils sont localises dans 6 nouveaux loci phma, b, c, d, e, f, ainsi que dans la region ma1b qui code pour les transporteurs du maltose. Dans un second temps, nous avons etudie les mecanismes de la ph-regulation des genes phma et ma1e. Dans ce but, nous avons clone et sequence les 2 fusions de genes correspondantes. D'une part, nous avons montre que le gene phma est identique au gene nmpc qui code pour une porine de la membrane externe. D'autre part, nous avons caracterise precisement le site d'insertion de la fusion dans le gene ma1e. L'isolement et l'utilisation de deletions d'etendue variee dans le promoteur du gene nmpc nous ont permis de montrer que la ph-regulation de ce gene est liee a l'action antagoniste du complexe cap-ampc et d'un represseur encore inconnu. Par ailleurs, l'obtention de mutants de la ph-regulation nous a conduit a caracteriser une mutation dans le gene ptsg, gene de la permease du glucose, qui peut, dans certains cas, annuler la ph-regulation du gene ma1e
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Lewis, Jennifer S. "Investigation of Group Leadership in a Fission-Fusion Species, the Bottlenose Dolphin." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/254.
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Consistent leadership of group travel by specific individuals has been documented in many animals. Most species exhibiting this type of leadership have relatively stable group membership. Animals using fission-fusion grouping are not expected to use specific leaders because associations would not be frequent. Certain conditions, however, may allow this type of control over group travel to occur. First, a population would need to be small enough to allow regular associations between individuals. Second, leadership may be useful if the environment where the population in question lives is complex and requires learning to access the resources efficiently. To determine whether fission-fusion species existing under these conditions utilize specific individual leadership, I examined a small residential population of bottlenose dolphins (Tursiops truncatus) in the Lower Florida Keys (LFK) where the benthic habitat is highly complex. My goals were to 1) determine whether specific individuals in this population led group travel more often than expected; 2) determine whether certain factors predicted which animals would lead most often and 3) investigate the benefits of leading to leaders and to followers in a fission-fusion society. Multiple types of data were collected to answer questions posed including dolphin behavior (for leadership analyses), fish sampling (to examine dolphin habitat use under leadership), and dolphin biopsy sampling (for genetic analyses). Results of analyses provided strong evidence for consistent leadership in this population. Leaders were female, most were mothers and on average they had larger measures of centrality within the LFK population. Leaders benefited by leading individuals who were more closely related than expected. Followers benefited from efficient access to profitable habitat. Results build on previous leadership research by expanding our knowledge about the type of species in which specific individuals lead and predictors for what types of individuals may lead. Additionally, results provide the first detailed information about benefits group members obtain by both leading and following.
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Strauss, Graham L. "Hybrid Fusion Protein for Inhibition of Multiple Proteases for Chronic Wound Healing." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7957.
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Many diseases display a multitude of relevant factors that contribute to the persistence of the disease and difficulty treating it. The multifactorial characteristics of some diseases lead to the requirement of combination of treatments in order to restore health. The latter may necessitate the mixing of treatments, medications, and therapeutics to first halt the disease, then assist the human body in returning itself to a state of normality. For example, chronic wounds exhibit this multifactor characteristic in which there exist many factors that lead to the body’s inability to properly heal in a timely manner. This presents a further threat to the body, such as exposure to infection and long-term pain. In this example, it is important to look at the ultimate cause of a chronic wound, which may be due to presence of other diseases impairing the body’s ability to properly heal. This may include diabetes, initial antibiotic-resistant infection, autoimmune disorders, and poor vasculature. Furthermore, the mentioned causes for chronic wounds may have associations with one another in a single case of a chronic wound. Treating each interrelated cause with drug combinations may run the risk of adverse side effects or further complications due to mixing drugs in a systemic method.
The goal of this study is to develop a point-specific, protein-based therapy that incorporates a single-protein molecule with multifunctional characteristics based on what we know about chronic wounds and infections, as a proof of concept of multifunctional proteins. Multifunctionality of a single therapeutic molecule is desirable because it may eliminate the unknowns of how differing individual chemical or protein therapies may interact when simply mixed. In addition, examples of peptides, such as antimicrobial peptides, are known to have synergy, and creating a single protein platform that consists of two synergistic peptides could be of value in the making of a protein with greater activity by guaranteeing that the synergistic peptides are local to one another. Furthermore, broad spectrum activity can be obtained by combining two differing peptides.
This proof of concept was accomplished by targeting two proteinases that are upregulated in chronic wounds: Matrix Metalloproteinase-2 (MMP-2) and Neutrophil Elastase. Recombinant DNA techniques were used to create a fusion protein that incorporates an inhibitor of MMP-2, which is a β-Amyloid Precursor Protein-derived Inhibitory Peptide (APP-IP), and PMP-D2, an inhibitor of Neutrophil Elastase. PMP-D2 was joined to the N-terminus of an Elastin-like peptide, while the APP-IP was joined to the C-terminus of the same Elastin-like peptide. Elastin-like peptides (ELPs) are commonly used as a backbone for recombinant protein production as their distinct thermoresponsive characteristics provide adequate protein purification using an inverse transition cycling [3]. In addition, ELPs can serve as point-specific drug delivery platforms with a transition temperature (Tt) near that of normal body temperature causing low diffusivity [3]. Therefore, when ELPs are applied to a site at their Tt, they will aggregate, which provides diffusional limitations of the protein in the application site, and may decrease the reapplication rate needed for a therapeutic, as well as eliminate adverse side effects by retaining the protein to the specific application site.
From this dual fusion, the final resulting protein is PMP-D2٠ELP٠APP-IP. This protein was tested for its inhibitory activity of both MMP-2 and Neutrophil Elastase. It was hypothesized that the fusion protein, PMP-D2٠ELP٠APP-IP, would inhibit MMP-2 just as effectively as APP-IP·ELP unaccompanied by PMP-D2, as well as effectively inhibit Neutrophil Elastase to the same degree as PMP-D2·ELP unaccompanied by APP-IP.
Furthermore, an additional dually fused ELP fusion protein was currently made with two synergistic antimicrobial peptides fused to each end of the ELP. The two antimicrobial peptides used were human-derived LL37 and insect-derived Cecropin A. This novel fusion peptide contains synergistic increase in antibacterial activity in which preliminary data suggests.
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Lu, Jingting. "E-services based information fusion: a user-level information integration framework." [Gainesville, Fla.]: University of Florida, 2002. http://purl.fcla.edu/fcla/etd/UFE0000566.
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Kalluri, Hemanth Reddy. "FUSION OF SPECTRAL REFLECTANCE AND DERIVATIVE INFORMATION FOR ROBUST HYPERSPECTRAL LAND COVER CLASSIFICATION." MSSTATE, 2009. http://sun.library.msstate.edu/ETD-db/theses/available/etd-11062009-124333/.
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Developments in sensor technology have made high resolution hyperspectral remote sensing data available to the remote sensing analyst for ground cover classification and target recognition tasks. Further, with limited ground-truth data in many real-life operating scenarios, such hyperspectral classification systems often employ dimensionality reduction algorithms. In this thesis, the efficacy of spectral derivative features for hyperspectral analysis is studied. These studies are conducted within the context of both single and multiple classifier systems. Finally, a modification of existing classification techniques is proposed and tested on spectral reflectance and derivative features that adapts the classification systems to the characteristics of the dataset under consideration. Experimental results are reported with handheld, airborne and spaceborne hyperspectral data. Efficacy of the proposed approaches (using spectral derivatives and single or multiple classifiers) as quantified by the overall classification accuracy (expressed in percentage), is significantly greater than that of these systems when exploiting only reflectance information.
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Prouteau, Gaëlle. "Contribution des produits de fusion de la croûte océanique subductée au magmatisme d'arc : exemples du Sud-Est asiatique et approche expérimentale." Brest, 1999. http://www.theses.fr/1999BRES2046.
Full textAbstract:
Les magmas adakitiques, produits de fusion des basaltes de la croute oceanique subductee, representent une faible fraction du volume total des magmas mis en place dans les zones de subduction/collision cenozoiques, mais leur frequence est bien superieure a celle qui etait initialement suspectee. De plus, l'etude geochimique des roches calco-alcalines des philippines et de borneo suggere qu'elles interviennent comme agent metasomatique du manteau sub-arc. Les experiences effectuees dans ce travail, soit sur une adakite (dacite du mont pinatubo), soit sur la source supposee des adakites (basalte altere) apportent de nouvelles contraintes sur les conditions physico-chimiques de genese de ces magmas. Nos donnees experimentales precisent les parametres physiques de la genese des adakites (temperatures moderees, fh 2o elevees, pressions probablement superieures a 20 kbar) mais elles indiquent aussi qu'il y a une contrainte chimique fondamentale qui autorisera, ou non, la preservation des liquides produits par cette fusion lors de la remontee lithospherique. Nos resultats experimentaux sur la fusion du basalte montrent clairement que la richesse en alcalins des liquides produits lors des premiers stades de la fusion partielle de la croute oceanique hydratee augmente avec la pression. La competition teneurs en alcalins (+h 2o)/pression de genese regira le degre d'interaction des liquides formes par fusion de la croute oceanique subductee. Ainsi, des liquides trondhjemitiques produits a 30 kbar, presentent un fort contraste chimique avec la composition de l'eutectique mantellique a 30 kbar, et interagiront fortement, suivant la reaction (1) avec les peridotites qu'ils percolent : olivine + liquide 1 = orthopyroxene + liquide 2 pargasite phlogopite (1) la reaction (1) modifie la composition mineralogique et chimique des peridotites percolees par de tels liquides. C'est peut-etre la qu'il faut chercher l'origine des basaltes enrichis en nb parfois associes aux adakites.