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Journal articles on the topic 'Eudragit RL100'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Mohapatra, P. K., C. H. Nagalakshmi, V. Tomer, et al. "Formulation and in Vitro Evaluation of Controlled Release Transdermal Drug Delivery System of Simvastatin A Model Hypocholesterolemia Drug." International Journal of Current Pharmaceutical Review and Research 9, no. 5 (2018): 71–76. https://doi.org/10.5281/zenodo.12674097.

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The intention of this research work was to develop a matrix-type transdermal drug delivery system (TDDS) containingsimvastatin an antilipidemic drug with different ratios of hydrophilic HPMC K100M and hydrophobic Eudragit RL100 &Eudragit RS100 polymers with surfactant Tween 80 and plasticizer glycerin by the solvent evaporation technique. Theprepared films were evaluated for physicochemical properties. Matrix films were evaluated for their physicochemicalcharacterization followed by in-vitro evaluation. The drug released rate was found to be increased when the concentrationof the polymer d

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Šveikauskaitė, Indrė, and Vitalis Briedis. "Effect of Film-Forming Polymers on Release of Naftifine Hydrochloride from Nail Lacquers." International Journal of Polymer Science 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/1476270.

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The successful topical therapy of onychomycosis depends on effective drug release and penetration into nail, which can be achieved by using an adequately developed delivery system. This study evaluated and compared effect of film-forming polymers Eudragit RL100, Eudragit RS100, and ethyl cellulose on naftifine hydrochloride release from experimental nail lacquer formulations. Quality of formulations was evaluated by determining drying time and water resistance. Interactions between active pharmaceutical ingredient and excipients were investigated using microcalorimetry and FT-IR. Optimization

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3

Dr.E, Hari Krishna T. Mallika *. DS Spandana M. Harika Raj S. Jyothi. "DEVELOPMENT AND EVALUATION OF METFORMIN HCL LOADED EUDRAGIT®RSPO AND EUDRAGIT®RLPO AND GLIMEPIRIDE BILAYER TABLETS." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3371–80. https://doi.org/10.5281/zenodo.1000995.

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The present study was carried out for developing the formulation of Bilayer tablets of Glimepiride, Metformin HCl. Immediate Release (IR) layer was compressed as direct compression method and Sustained Release (SR) layer blends were compressed by wet granulation method. IR and SR layers were evaluated for pre and post compression studies and all studies were found to be within limits. From dissolution data of Glimepiride Immediate release layer, IR5 formulation was shown maximum drug release at 60 min i.e., 96.4%. Hence IR5was concluded as optimised formulation for IR layer. Sustained layer co

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4

Tiwari, Ruchi, Birendra Srivastava, Gaurav Tiwari, and Awanik Rai. "Extended release promethazine HCl using acrylic polymers by freeze-drying and spray-drying techniques: formulation considerations." Brazilian Journal of Pharmaceutical Sciences 45, no. 4 (2009): 829–40. http://dx.doi.org/10.1590/s1984-82502009000400029.

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The present study investigated a novel extended release system of promethazine hydrochloride (PHC) with acrylic polymers Eudragit RL100 and Eudragit S100 in different weight ratios (1:1 and 1: 5), and in combination (0.5+1.5), using freeze-drying and spray-drying techniques. Solid dispersions were characterized by Fourier-transformed infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), Nuclear magnetic resonance (NMR), Scanning electron microscopy (SEM), as well as solubility and in vitro dissolution studies in 0.1 N HCl (pH 1.2), double-d

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Patil, Pravin S., and Shashikant C. Dhawale. "DEVELOPMENT OF RITONAVIR LOADED NANOPARTICLES: IN VITRO AND IN VIVO CHARACTERIZATION." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 284. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.23145.

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Objective: The purpose of the present investigation was to develop a nanosuspension to improve dissolution rate and oral bioavailability of ritonavir.Methods: Extended-release ritonavir loaded nanoparticles were prepared using the polymeric system by nanoprecipitation technique. Further, the effect of Eudragit RL100 (polymeric matrix) and polyvinyl alcohol (surfactant) was investigated on particle size and distribution, drug content, entrapment efficiency, and in vitro drug release from nanosuspension where a strong influence of polymeric contents was observed. Drug-excipient compatibility and

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Shinde, Ujwala A., Jaykumar N. Shete, Hema A. Nair, and Kavita H. Singh. "Eudragit RL100 based microspheres for ocular administration of azelastine hydrochloride." Journal of Microencapsulation 29, no. 6 (2012): 511–19. http://dx.doi.org/10.3109/02652048.2012.665088.

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7

Bucolo, Claudio, Adriana Maltese, Francesco Maugeri, Barbara Busà, Giovanni Puglisi, and Rosario Pignatello. "Eudragit RL100 nanoparticle system for the ophthalmic delivery of cloricromene." Journal of Pharmacy and Pharmacology 56, no. 7 (2004): 841–46. http://dx.doi.org/10.1211/0022357023835.

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8

Pandey, Vivek Kumar, Kumar Rohit Srivastava, Gufran Ajmal, et al. "Differential Susceptibility of Catheter Biomaterials to Biofilm-Associated Infections and Their Remedy by Drug-Encapsulated Eudragit RL100 Nanoparticles." International Journal of Molecular Sciences 20, no. 20 (2019): 5110. http://dx.doi.org/10.3390/ijms20205110.

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Biofilms are the cause of major bacteriological infections in patients. The complex architecture of Escherichia coli (E. coli) biofilm attached to the surface of catheters has been studied and found to depend on the biomaterial’s surface properties. The SEM micrographs and water contact angle analysis have revealed that the nature of the surface affects the growth and extent of E. coli biofilm formation. In vitro studies have revealed that the Gram-negative E. coli adherence to implanted biomaterials takes place in accordance with hydrophobicity, i.e., latex > silicone > polyurethane &gt

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H. Hussain, Ahmed, and Yehia I.Khalil. "Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 17, no. 1 (2017): 1–6. http://dx.doi.org/10.31351/vol17iss1pp1-6.

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An inert matrix that is used to control the release of (PTX) was prepared using Eudragit RL100 and RSPM types as matrix forming agent . The matrices were prepared by either dry granulation(slugging) , or wet granulation method using chloroform as a solvent evaporation vehichle. The cumulative release was adjusted by using polyvinylpyrollidone (PVP) or ethylcellulose (EC) polymers .The results indicated that both methods of preparation were valid for incorporation PTX as a sustained release granules .Moreover ,the results revealed that best polymer used was Eudragit RSPM in 3:20 polymer drug ra

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Noor, Amjed H., and Mowafaq M. Ghareeb. "Formulation and Evaluation of Ondansetron HCl Nanoparticles for Transdermal Delivery." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 29, no. 2 (2020): 70–79. http://dx.doi.org/10.31351/vol29iss2pp70-79.

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Ondansetron HCl (OND) is a potent antiemetic drug used for control of nausea and vomiting associated with cancer chemotherapy. It exhibits only 60 – 70 % of oral bioavailability due to first pass metabolism and has a relative short half-life of 3-5 hours. Poor bioavailability not only leads to the frequent dosing but also shows very poor patient adherence. Hence, in the present study an approach has been made to develop OND nanoparticles using eudragit® RS100 and eudragit® RL100 polymer to control release of OND for transdermal delivery and to improve patient compliance. Six formulas of

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Dillen, Kathleen, Jo Vandervoort, Guy Van den Mooter, and Annick Ludwig. "Evaluation of ciprofloxacin-loaded Eudragit® RS100 or RL100/PLGA nanoparticles." International Journal of Pharmaceutics 314, no. 1 (2006): 72–82. http://dx.doi.org/10.1016/j.ijpharm.2006.01.041.

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12

Mandal, Bivash, Kenneth S. Alexander, and Alan T. Riga. "Preparation and physicochemical characterization of Eudragit® RL100 Nanosuspension with potential for Ocular Delivery of Sulfacetamide." Journal of Pharmacy & Pharmaceutical Sciences 13, no. 4 (2010): 510. http://dx.doi.org/10.18433/j3sw2t.

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Purpose: Polymeric nanosuspension was prepared from an inert polymer resin (Eudragit® RL100) with the aim of improving the availability of sulfacetamide at the intraocular level to combat bacterial infections. Methods: Nanosuspensions were prepared by the solvent displacement method using acetone and Pluronic® F108 solution. Drug to polymer ratio was selected as formulation variable. Characterization of the nanosupension was performed by measuring particle size, zeta potential, Fourier Transform infrared spectra (FTIR), Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD),

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Pignatello, Rosario, Daniela Spadaro, Maria Angela Vandelli, Flavio Forni, and Giovanni Puglisi. "Characterization of the Mechanism of Interaction in Ibuprofen‐Eudragit RL100® Coevaporates." Drug Development and Industrial Pharmacy 30, no. 3 (2004): 277–88. http://dx.doi.org/10.1081/ddc-120030421.

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Aisha, Abdalrahim F. A., Amin Malik Shah Abdulmajid, Zhari Ismail, Salman A. Alrokayan, and Khalid M. Abu-Salah. "Development of Polymeric Nanoparticles ofGarcinia mangostanaXanthones in Eudragit RL100/RS100 for Anti-Colon Cancer Drug Delivery." Journal of Nanomaterials 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/701979.

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Xanthones are a group of oxygenated heterocyclic compounds with anticancer properties, but poor aqueous solubility and low oral bioavailability hinder their therapeutic application. This study sought to prepare a xanthones extract (81% α-mangostin and 16% γ-mangostin) in polymeric nanoparticles and to investigate its intracellular delivery and cytotoxicity toward colon cancer cells. The nanoparticles were prepared in Eudragit RL100 and Eudragit RS100 by the nanoprecipitation method at drug loading and entrapment efficiency of 20% and >95%, respectively. Freeze-drying of bulk nanoparticle so

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D. Shivhare, Umesh, Vikrant P. Dorlikar, Kishore P. Bhusari, Vijay B. Mathur, and Bhiku N. Mirani. "Effect of Polymeric Compositions on Pharmacotechnical Properties of Carvedilol Transdermal Film." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (2009): 457–64. http://dx.doi.org/10.37285/ijpsn.2009.2.1.10.

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Transdermal films of carvedilol were prepared by using Eudragit RL100 (ERL100) either alone or in combination with Eudragit RS100 (ERS100), hydroxypropyl methylcellulose K 15 LV (HPMC), and ethyl cellulose (EC). The drug release was extended over a period of 24 h from all formulations. The formulation A5 showed 98.33 cumulative % drug releases in 24 h and followed zero order kinetics. The drug transport mechanism was observed to be Fickian. The cumulative % drug diffused through artificial permeation membrane (cellophane A 393) from same formulation was 100.52 % over a 12 h. The mechanism of d

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Soujanya, B., J. Geethanjali, D. Mounika, and V. Saikishore. "Influence of Casting Solvent and Polymer on Permeability of Propranolol Hydrochloride Through Eudragit RL100 and Eudragit RLPO Films." Research Journal of Pharmaceutical Dosage Forms and Technology 7, no. 1 (2015): 69. http://dx.doi.org/10.5958/0975-4377.2015.00010.5.

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17

Tanwar, Yuveraj, Chetan Chauhan, and Anshu Sharma. "Development and evaluation of carvedilol transdermal patches." Acta Pharmaceutica 57, no. 2 (2007): 151–59. http://dx.doi.org/10.2478/v10007-007-0012-x.

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Development and evaluation of carvedilol transdermal patchesTransdermal patches of carvedilol with a HPMC-drug reservoir were prepared by the solvent evaporation technique. In this investigation, the membranes of Eudragit RL100 and Eudragit RS100 were cast to achieve controlled release of the drug. The prepared patches possessed satisfactory physicochemical characteristics. Thickness, mass and drug content were uniform in prepared batches. Moisture vapour transmission through the patches followed zero-order kinetics.In vitropermeation studies were performed using a K-C diffusion cell across ha

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Kumar, Sahoo Sunit, Baurahari Behury, and Patil Sachinkumar. "Formulation and Evaluation of Transdermal Patch of Stavudine." Dhaka University Journal of Pharmaceutical Sciences 12, no. 1 (2013): 63–69. http://dx.doi.org/10.3329/dujps.v12i1.16302.

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Stavudine has the half life of 1 to 1.5 hour and bioavailability in the body is 86% due to first-pass metabolism. The dose of stavudine is 40 mg two to three times daily depending on weight and gender; hence, it requires frequent dosing. Transdermal patch of stavudine was prepared to sustain the release and improve bioavailability of drug and patient compliance. Different formulations were prepared by using different concentrations of Eudragit RS 100 and Eudragit RL 100. The prepared formulations were evaluated for various parameters like weight, thickness, drug content, percentage moisture co

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Salvi, Vedanti, and Pravin Pawar. "Eudragit RL100 Based Moxifloxacin Hydrochloride and Ketorolac Tromethamine Combination Nanoparticulate System for Ocular Drug Delivery." Pharmaceutical Nanotechnology 8, no. 2 (2020): 133–47. http://dx.doi.org/10.2174/2211738508666200313140902.

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Background: Bacterial conjunctivitis is a serious ocular infection if left untreated. It is caused by several species of bacteria like Pseudomonas, Staphylococcus and Mycobacterium. Objective: The present investigation explores the development and characterization of moxifloxacin hydrochloride and ketorolac tromethamine combination loaded Eudragit RL 100 nanosuspension for ocular drug delivery in order to overcome the problems associated with conventional dosage forms. Methods: The nanosuspension prepared by nanoprecipitation technique showed successful entrapment of both water-soluble drugs i

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Gupta, BijanKumar, Rabindranath Pal, Manas Chakraborty, and Rabindra Debnath. "Design, evaluation and optimization of microcapsules of leflunomide with Eudragit®RL100 and Eudragit®RS. 100 by solvent evaporation technique." Asian Journal of Pharmaceutics 3, no. 4 (2009): 309. http://dx.doi.org/10.4103/0973-8398.59957.

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21

Jethva, Jayesh K., Chintan H. Trivedi, Sarita P. Ratanpara, Geeta R. Bathwar, and Ramesh B. Parmar. "Pharmaceutical Development and Evaluation of Reservoirtype Ciprofloxacin Ocular Insert." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 4 (2015): 3024–30. http://dx.doi.org/10.37285/ijpsn.2015.8.4.5.

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Ocular inserts of ciprofloxacin hydrochloride were prepared with the aim of achieving once a day administration. Drug reservoir was prepared using sodium CMC while rate controlling membrane was prepared using Eudragit RS100 and RL100. Ocular inserts were evaluated for their physicochemical parameters like thickness, weight uniformity, drug content, percent moisture loss, and percent moisture absorption. The in vitro drug release studies were carried out using Bi-chambered donor receiver compartment model. In vitro drug release kinetic data was treated according to Zero, First, and Higuchi kine

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Sunil Aher, Poonam Patil, Kiran Mahajan, et al. "Formulation and Evaluation of Lornoxicam Nanosuspension with Eudragit Rs100 Polymer." Journal of Advanced Zoology 44, S-5 (2023): 2227–37. http://dx.doi.org/10.17762/jaz.v44is-5.1823.

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BCS Class II has a low aqueous solubility problem in pharmaceutical formulation. Hence to overcome this problem this research the was carried out for BCS Class II drug lornoxicam was selected to enhance the aqueous solubility by formulating nanosuspension with a polymer like Eudragit RL100, Eudragit RS100 and Poloxamber407 as a stabilizer. The present study focuses on the polymer Eudragit RS100. A total of four formulations LRS-F1, LRS-F2, LRS-F3, LRS-F4, and LRS-F4 were prepared with a ratio of drug: polymer: stabilizer (1:1:0.5 & 1:2:0.5, 1:1:1 & 1:2:1)LRS-F4 formulation was found to

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Das, S. K., and N. G. Das. "Preparation andin vitrodissolution profile of dual polymer (Eudragit RS100 and RL100) microparticles of diltiazem hydrochloride." Journal of Microencapsulation 15, no. 4 (1998): 445–52. http://dx.doi.org/10.3109/02652049809006871.

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Kondapuram, Parameshwar, and Suvendu K. Sahoo. "Development and Characterization of Eudragit Rl100 Nanoparticle Loaded Duloxetine Hydrochloride Gel for Transdermal Drug Delivery." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1618–25. http://dx.doi.org/10.25258/ijddt.12.4.24.

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Purpose: The study sought to examine the feasibility of transdermal delivery of duloxetine hydrochloride from a nano-gel and in-vitro assessment of the gel to demonstrate improved solubility and drug absorption from in-vitro permeation studies using rat skin. Materials and Methods: Six formulas of amorphous duloxetine hydrochloride-loaded nanoparticle (NP) using eudragit RL 100 and Tween 80 as a stabilizer in the different ratios of ethanol by the solvent antisolvent technique. The physicochemical critiques of the amorphous duloxetine hydrochloride-loaded NP have completed the best formulation

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Nath, Bipul, Lila Kanta Nath, Bhaskar Mazumdar, Niraj Sharma, and Mrinal Sarkar. "Design and Development of Metformin HCl Floating Microcapsules using Two Polymers of Different Permeability Characteristics." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 627–37. http://dx.doi.org/10.37285/ijpsn.2009.2.3.6.

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The objective of the present investigation was to design a sustained release floating microcapsules of Metformin HCl using two polymers of different permeability characteristics Cellulose acetate butyrate (MW of 16,000) and Eudragit RL100 (MW of 150,000) using the oil-in-oil emulsion solvent evaporation method. Polymers were used separately and in combination (1:1) to prepare different microcapsules using acetone as organic phase. In all batches of microcapsules, the total polymer concentration was kept constant (10%w/w). No significant differences in drug loading in microcapsules made from di

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Pratima, Parashar. "SYNTHESIS OF SILVER NANOCOPOSITE WITH EUDRAGIT RL 100 FOR THE DRUG DELIVERY SYSTEM." International Journal of Education &Applied Sciences Research 1, no. 3 (2014): 51–54. https://doi.org/10.5281/zenodo.10683259.

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<em>Abstract</em> <em>Vacuum deposited </em><em>thin discontinuous silv</em><em>er films on Eudragit RL 100 (Eu) were produced. Eudragit RL100 is insoluble in water at physiological pH values and capable of swelling, so they are good for the dispersion of active compounds. This polymer is being used for the enteric coating of tablets and for preparing controlled-release formulations. Hence, deposition of silver nano cluster on Eu would be useful for drug delivery system. The unique properties of silver nano particles (Ag NP) have been exploited within the fields of photonics and biotechnology

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Melo, Carolina Mirtes, Jéssica Ferreira Cardoso, Fernanda Barçante Perassoli, et al. "Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis." Carbohydrate Polymers 230 (February 2020): 115608. http://dx.doi.org/10.1016/j.carbpol.2019.115608.

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Dewan, Irin, Swarnali Islam, and Md Sohel Rana. "Characterization and Compatibility Studies of Different Rate Retardant Polymer Loaded Microspheres by Solvent Evaporation Technique: In Vitro-In Vivo Study of Vildagliptin as a Model Drug." Journal of Drug Delivery 2015 (November 12, 2015): 1–12. http://dx.doi.org/10.1155/2015/496807.

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The present study has been performed to microencapsulate the antidiabetic drug of Vildagliptin to get sustained release of drug. The attempt of this study was to formulate and evaluate the Vildagliptin loaded microspheres by emulsion solvent evaporation technique using different polymers like Eudragit RL100, Eudragit RS100, Ethyl cellulose, and Methocel K100M. In vitro dissolution studies were carried out in 0.1 N HCl for 8 hours according to USP paddle method. The maximum and minimum drug release were observed as 92.5% and 68.5% from microspheres, respectively, after 8 hours. Release kinetics

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Pignatello, Rosario, Marinella Ferro, Guido De Guidi, et al. "Preparation, characterisation and photosensitivity studies of solid dispersions of diflunisal and Eudragit RS100® and RL100®." International Journal of Pharmaceutics 218, no. 1-2 (2001): 27–42. http://dx.doi.org/10.1016/s0378-5173(01)00597-x.

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Dieng, Sidy Mouhamed, Ziad Omran, Nicolas Anton, et al. "Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for poorly soluble drugs." Colloids and Surfaces B: Biointerfaces 191 (July 2020): 111010. http://dx.doi.org/10.1016/j.colsurfb.2020.111010.

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Pignatello, R., C. Bucolo, and G. Puglisi. "Ocular Tolerability of Eudragit RS100® and RL100® Nanosuspensions as Carriers for Ophthalmic Controlled Drug Delivery." Journal of Pharmaceutical Sciences 91, no. 12 (2002): 2636–41. http://dx.doi.org/10.1002/jps.10227.

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Srilatha Malvey, Venkateshwar Rao J, and Kottaimuthu A. "Formulation of flurbiprofen transdermal patche: In vitro and Ex vivo report." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (2019): 2661–69. http://dx.doi.org/10.26452/ijrps.v10i4.1524.

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The main aim of this study was to expand the present formulation with patch and to evaluate the transdermal patches of Flurbiprofen, NSAID (Non-Steroidal Anti-Inflammatory Drug) used in the treatment of arthritis. Flurbiprofen is required at a sustained rate of its short half- life (3-4 hours) long term percutaneous absorption is required for its gastrointestinal side effects. Hence in this study, an effort was done to develop transdermal patches of Flurbiprofen by employing a different combination of polymers were prepared by the solvent evaporation technique. Nine formulations were prepared

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Geppi, Marco, Salvatore Guccione, Giulia Mollica, Rosario Pignatello, and Carlo A. Veracini. "Molecular Properties of Ibuprofen and Its Solid Dispersions with Eudragit RL100 Studied by Solid-State Nuclear Magnetic Resonance." Pharmaceutical Research 22, no. 9 (2005): 1544–55. http://dx.doi.org/10.1007/s11095-005-6249-5.

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Rigon, Cristina, Laura Minussi Giuliani, Mônica Fabiele Lorensi Stangarlin, et al. "SISTEMAS NANOESTRUTURADOS CONTENDO ÓLEO DE LINHAÇA: DESENVOLVIMENTO TECNOLÓGICO E CARACTERIZAÇÃO FÍSICO-QUÍMICA DE NANOEMULSÕES E NANOCÁPSULAS POLIMÉRICAS." Saúde (Santa Maria) 43, no. 1 (2017): 153. http://dx.doi.org/10.5902/2236583422819.

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O óleo de linhaça apresenta diversas propriedades terapêuticas, principalmente devido à presença de ácidos poli-insaturados em sua composição. Para melhor eficácia e/ou aumento da estabilidade de óleos vegetais farmacologicamente ativos, sistemas nanoestruturados são desenvolvidos para veiculação deste tipo de substância. Este estudo objetivou desenvolver e caracterizar sistemas nanoestruturados contendo óleo de linhaça. Foram preparadas nanocápsulas poliméricas e nanoemulsões, avaliando-se duas concentrações de óleo (1,5% e 3,0%) em ambas as formulações e dois polímeros, Poli(ε-caprolactona)

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Sana, mubeen Ghulam Razaque Noman ul haq Nisar ahmed G. Mustafa Shahwani Zarmeena khan Aqeel Nasim M. Zeeshan Danish. "FORMULATION DEVELOPMENT OF CR OFLAXACIN MATRIX TABLET AND THEIR IN-VITRO EVALUATION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2572–79. https://doi.org/10.5281/zenodo.1219957.

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Among the all sophisticated drug deliveries oral drug delivery is known as safest and most convenient rout of administration. DDS are formulated for rapid release, for CDD (Controlled Drug delivery and release) and for targeted drug delivery. Controlled delivery system is the system which deliver the active ingredient at a predetermined rate and time for the local or systemic effect for a definite period of time. Formulation and development of CR made possible by the polymers i.e is synthetic polymers and natural polymers. Eudragit is an Synthetic amorphous polymer, which is non absorbable, no

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Ganesh, R. Nayak1* Krishnananda Kamath K.1 Akshay Killekar2 A. R. Shabaraya1. "Development Of Carvedilol Nanoparticles As Antihypertensive Agent." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1794–802. https://doi.org/10.5281/zenodo.12807949.

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In the present work, an attempt was made to formulate nanoparticles of carvedilol, to increase the bioavailability of Carvedilol. Carvedilol is an antihypertensive agent, nonselective ß-blocker of low molecular weight 406.47 gm/mol BCS class II undergoes extensive hepatic first-pass metabolism (75% - 80%), with an oral bioavailability of 20 to 25% and a half-life of 7 hrs. The dosage for hypertension is 3.25 to 12.5 mg twice daily for the first 2 days and can then be increased if necessary to 50 mg daily. The prepared nanoparticles were formulated using Eudragit RL100 as the rate-control

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Ganesh, Nayak* Krishnananda Kamath K. Akshay Killekar A. R. Shabaraya. "Development Of Carvedilol Nanoparticles As Antihypertensive Agent." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 2010–18. https://doi.org/10.5281/zenodo.13115922.

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In the present work, an attempt was made to formulate nanoparticles of carvedilol, to increase the bioavailability of Carvedilol. Carvedilol is an antihypertensive agent, nonselective ß-blocker of low molecular weight 406.47 gm/mol BCS class II undergoes extensive hepatic first-pass metabolism (75% - 80%), with an oral bioavailability of 20 to 25% and a half-life of 7 hrs. The dosage for hypertension is 3.25 to 12.5 mg twice daily for the first 2 days and can then be increased if necessary to 50 mg daily. The prepared nanoparticles were formulated using Eudragit RL100 as the rate-co

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Wang, Ying, Lin Liu, Yuanjie Zhu, Liangzhe Wang, Deng-Guang Yu, and Li-ying Liu. "Tri-Layer Core–Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole." Pharmaceutics 15, no. 11 (2023): 2561. http://dx.doi.org/10.3390/pharmaceutics15112561.

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Polymers are the backbone of drug delivery. Electrospinning has greatly enriched the strategies that have been explored for developing novel drug delivery systems using polymers during the past two decades. In this study, four different kinds of polymers, i.e., the water-soluble polymer poly (vinyl alcohol) (PVA), the insoluble polymer poly(ε-caprolactone) (PCL), the insoluble polymer Eudragit RL100 (ERL100) and the pH-sensitive polymer Eudragit S100 (ES100) were successfully converted into types of tri-layer tri-polymer core–shell fibers through bi-fluid coaxial electrospinning. During the co

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Medipelli, Anitha, and Praveena Chinthala. "Formulation and In-Vitro Assessment of Torsemide -Loaded Microspheres for Controlled Drug Delivery." Biosciences Biotechnology Research Asia 21, no. 4 (2024): 1605–14. https://doi.org/10.13005/bbra/3329.

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ABSTRACT: The present work aimed at formulation development and evaluation of Torsemide (TOR) microspheres. The loop diuretic TOR is used to treat congestive heart failure and edema. Due to its short half-life of two to three hours, weak basicity, and high solubility, TOR is released rapidly and does not provide sustained drug release. To achieve controlled drug release at a predetermined rate, TOR was prepared into microspheres. A total of 12 formulations were prepared by combining Sodium alginate with varying proportions of the polymers Eudragit RL100 and Hydroxy propyl methyl cellulose K15

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Corsaro, Roberta, Rosamaria Lombardo, Carla Ghelardini, et al. "Development of Eudragit® Nanoparticles for Intranasal Drug Delivery: Preliminary Technological and Toxicological Evaluation." Applied Sciences 12, no. 5 (2022): 2373. http://dx.doi.org/10.3390/app12052373.

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Intranasal administration has assumed in the last years an increasing value as an alternative strategy for the systemic adsorption of drugs, as an alternative to oral and parenteral routes thanks to the high vascularized nasal mucosa. Nevertheless, different drug features may restrict its absorption through the nasal mucosa with an insufficient diffusion to the systemic circulation. Several technological strategies are under investigation to improve drug absorption during nasal formulation design and production. The use of bioadhesive polymers can be considered a valid approach to pursue the a

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Abbas, Nazar, Akhtar Rasul, Ghulam Abbas, Shahid Shah, and Muhammad Hanif. "Targeted delivery of aspirin and metformin to colorectal cancer using disulfide bridged nanoparticles of thiolated pectin and thiolated Eudragit RL100." Materials Today Communications 35 (June 2023): 105586. http://dx.doi.org/10.1016/j.mtcomm.2023.105586.

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Reddy, Shimmula R., and Bomma Ramesh. "In vivo Evaluation of Fluvoxamine Maleate Mouth Dissolving Films by Design of Experiment." International Journal of Pharmaceutical Sciences and Drug Research 13, no. 03 (2020): 326–33. http://dx.doi.org/10.25004/ijpsdr.2021.130313.

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Fluvoxamine, an antidepressant belonging to serotonin reuptake inhibitor (SRI) class, exhibits maximum absorption through the oral route of administration. The objective of current research is to formulate mouth dissolving fluvoxamine films by employing super disintegrants. The central composite design (CCD), employed to examine the effects of amount of hydroxypropyl methylcellulose (HPMC) E15 (A), amount of eudragit RL 100 (B), amount of polyethylene glycol (PEG 4000) (C) on response variables tensile strength, disintegration time and cumulative % drug released. A 27 formulations prepared acc

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Ofokansi, Kenneth Chibuzor, and Franklin Chimaobi Kenechukwu. "Formulation Development and Evaluation of Drug Release Kinetics from Colon-Targeted Ibuprofen Tablets Based on Eudragit RL 100-Chitosan Interpolyelectrolyte Complexes." ISRN Pharmaceutics 2013 (August 6, 2013): 1–8. http://dx.doi.org/10.1155/2013/838403.

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Colon-targeted drug delivery systems (CTDDSs) could be useful for local treatment of inflammatory bowel diseases (IBDs). In this study, various interpolyelectrolyte complexes (IPECs), formed between Eudragit RL100 (EL) and chitosan (CS), by nonstoichiometric method, and tablets based on the IPECs, prepared by wet granulation, were evaluated as potential oral CTDDSs for ibuprofen (IBF). Results obtained showed that the tablets conformed to compendial requirements for acceptance and that CS and EL formed IPECs that showed pH-dependent swelling properties and prolonged the in vitro release of IBF

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Šveikauskaitė, Indrė, and Vitalis Briedis. "Potential of Naftifine Application for Transungual Delivery." Molecules 25, no. 13 (2020): 3043. http://dx.doi.org/10.3390/molecules25133043.

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Naftifine is used to treat fungal skin infections as it inhibits dermatophytes, which are the cause of onychomycosis. However, naftifine’s ability to permeate the human nail barrier has not been investigated, thus, the antimycotic potential is not clearly established. This work aims to evaluate the effect of penetration enhancing factors on the accumulation of naftifine hydrochloride through human nail clippings. Naftifine polymeric nail lacquers with Eudragit RL100 were developed as a suitable delivery system. Low penetration of naftifine into nail has been determined as less than 10% of appl

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Saxena, Ankita, Gulab Tewari, and Shubhini Awasthi Saraf. "Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon." Brazilian Journal of Pharmaceutical Sciences 47, no. 4 (2011): 887–97. http://dx.doi.org/10.1590/s1984-82502011000400026.

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Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl methyl cellulose (K4M), hydroxy propyl methyl cellulose (K15M), sodium carboxy methyl cellulose and poly vinyl pyrolidone (K30), plasticizer poly ethylene glycol (400) and a backing membrane of Eudragit (RL100). The films were evaluated in terms of swelling, residence time, mucoadhesion, release,

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Tiwari, Ruchi, Gaurav Tiwari, Pranaywal S, and Ankitawal A. "Dissolution Modulating Mechanism of Flurbiprofen Solid Dispersions: Characterization, Physical Stability and in vivo Performance: Formulation Considerations and optimization study." Pharmaceutical Methods 8, no. 2 (2017): 01–09. https://doi.org/10.5281/zenodo.14855482.

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Present work studied interaction between Surelease, Urea, and Eudragit RL100 (RL) polymers with nonsteroidal anti-inflammatory drug FLP. Solid dispersions at different weight ratios were prepared by fusion (Method A) and coprecipitation (Method B). Characterization of solid dispersions (SDs) included elemental analysis, Fourier transform (FTIR), Differential scanning calorimetry (DSC), Powder-x-ray diffractometry (XRD), Scanning electron microscopy (SEM) as well as wettability study, angle of repose, aqueous solubility determination, in vitro and in vivo drug release. FTIR studies showed the s

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Yen, Tran Thi Hai, Nguyen Tran Linh, Vu Thi Thu Giang, and Hoang Lan Anh. "Polymeric Nanoparticles Loaded with Acyclovir: Formulation, Characterization and In-Vitro Drug Prolonged-Release Study." Current Nanomedicine 10, no. 3 (2020): 271–79. http://dx.doi.org/10.2174/2468187310999200701215154.

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Objectives: Acyclovir (ACV) is an antiviral drug, which requires frequent dosing regimen because of poor oral bioavailability and short half-life. In this study, ACV nanoparticles were formulated using ammonium methacrylates copolymers such as Eudragit RS 100 (Eud RS) and Eudragit RL 100 (Eud RL) to prolong release drug, and increase bioavailability. Methods: ACV loaded nanoparticles were prepared by the solvent replacement technique and then were characterized by particle size, distribution, entrapment efficiency, differential scanning calorimeter, transmission electron microscope, and in-vit

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Mollica, Giulia, Marco Geppi, Rosario Pignatello, and Carlo A. Veracini. "Molecular Properties of Flurbiprofen and its Solid Dispersions with Eudragit RL100 Studied by High- and Low-Resolution Solid-State Nuclear Magnetic Resonance." Pharmaceutical Research 23, no. 9 (2006): 2129–40. http://dx.doi.org/10.1007/s11095-006-9044-z.

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Lombardo, Rosamaria, Marika Ruponen, Jarkko Rautio, et al. "Development of Lyophilised Eudragit® Retard Nanoparticles for the Sustained Release of Clozapine via Intranasal Administration." Pharmaceutics 15, no. 5 (2023): 1554. http://dx.doi.org/10.3390/pharmaceutics15051554.

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Clozapine (CZP) is the only effective drug in schizophrenia resistant to typical antipsychotics. However, existing dosage forms (oral or orodispersible tablets, suspensions or intramuscular injection) show challenging limitations. After oral administration, CZP has low bioavailability due to a large first-pass effect, while the i.m. route is often painful, with low patient compliance and requiring specialised personnel. Moreover, CZP has a very low aqueous solubility. This study proposes the intranasal route as an alternative route of administration for CZP, through its encapsulation in polyme

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MD, Rawoof, Rajnarayana K, and Ajitha M. "Development and In Vivo Evaluation of Mesalazine Colon Targeted Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 3 (2019): 4552–58. http://dx.doi.org/10.37285/ijpsn.2019.12.3.6.

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The main objective of the present study was to develop colon-targeted tablets of mesalazine by wet granulation method using 33 Response surface method with design of experiment software and HPMC K4M, Eudragit RL100, Ethyl cellulose and PVP K-30 used as pH dependent polymers. All the formulations (F1 to F27) were evaluated for the physicochemical parameters and were subjected to in vitro drug release studies. The amount of Mesalazine released from tablets at different time intervals was estimated by UV spectrophotometer. The formulation F26 released 98.16 % of mesalazine after 24 h, whereas mar

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