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Journal articles on the topic 'Eudragit RSPO'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Cetin, Meltem, Alptug Atila, Selma Sahin, and Imran Vural. "Preparation and characterization of metformin hydrochloride loaded-Eudragit®RSPO and Eudragit®RSPO/PLGA nanoparticles." Pharmaceutical Development and Technology 18, no. 3 (2011): 570–76. http://dx.doi.org/10.3109/10837450.2011.604783.

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Tagami, Tatsuaki, Maya Okamura, Koki Ogawa, and Tetsuya Ozeki. "Fabrication of Mucoadhesive Films Containing Pharmaceutical Ionic Liquid and Eudragit Polymer Using Pressure-Assisted Microsyringe-Type 3D Printer for Treating Oral Mucositis." Pharmaceutics 14, no. 9 (2022): 1930. http://dx.doi.org/10.3390/pharmaceutics14091930.

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Oral mucositis in the oral cavity, caused by radiation therapy and chemotherapy, requires personalized care and therapy due to variations in the lesions of patients. In the present study, we fabricated a model of personalized oral film containing an ibuprofen/lidocaine ionic liquid (IL) for patients with oral mucositis using a pressure-assisted microsyringe-type 3D printer at room temperature. The film contained a Eudragit polymer (L100, EPO, or RSPO) to make the film solid, and the printer ink was composed of organo ink (organic solvent to dissolve both drugs and the Eudragit polymer). The vi

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3

Sanghai, Piyush, Tanaji Nandgude, and Sushilkumar Poddar. "Formulation of Bilayer Benzydamine HCl Patch Targeted For Gingivitis." Journal of Drug Delivery 2016 (December 29, 2016): 1–9. http://dx.doi.org/10.1155/2016/7598398.

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In the present study bilayer patch of benzydamine HCl was developed using solvent casting method. Different substrates were attempted like Petri dish, glass-and-ring, and teflon-and-ring for selection of the proper option to formulate patch that should give easily peelable film with adequate mechanical properties. HPMC E15 LV was used in different concentrations for obtaining proper viscosity of solution for pouring on to surface and ring, that it should not leak from ring. The second layer was optimized by using different polymer like eudragit RSPO, eudragit RSPO + EC, and eudragit NE30 D for

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Thireesha, Bannaravuri, Ayya Rajendra Prasad, and Haroled Peter P L. "FORMULATION AND EVALUATION OF LORNOXICAM MICROSPONGES USING EUDRAGIT RS 100 AND EUDRAGIT RSPO." Asian Journal of Pharmaceutical and Clinical Research 11, no. 10 (2018): 217. http://dx.doi.org/10.22159/ajpcr.2018.v11i10.26861.

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Objective: The objective of the present study was preparation and evaluation of lornoxicam microsponges to prolong their drug release up to 12 h for effective osteoarthritis, rheumatoid arthritis, and acute lumbar-sciatica therapy.Methods: Lornoxicam microsponges were prepared by the quasi-emulsion solvent diffusion technique using different concentrations of polymers such as Eudragit RS 100 and Eudragit RSPO in ethanol and dichloromethane organic solvent mixture. Microsponges were evaluated for their particle size, percentage yield, entrapment efficiency, scanning electron microscopy (SEM), a

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Hasan, Ikramul, Shovan Paul, Sharmin Akhter, Navid Jubaer Ayon, and Md Selim Reza. "Evaluation and Optimization of Influence of Permeability Property and Concentration of Polymethacrylic Polymers on Microspheres of Metformin HCl." Dhaka University Journal of Pharmaceutical Sciences 12, no. 2 (2014): 131–41. http://dx.doi.org/10.3329/dujps.v12i2.17611.

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Metformin HCl microspheres were prepared with the aim of increasing its bioavailability and decreasing gastrointestinal side effects by means of sustained action. Eudragit RSPO and Eudragit RLPO, polymers of different permeability characteristics were used to prepare different microspheres. Emulsification solvent evaporation technique using acetone as the internal phase and liquid paraffin as the external phase was the method of choice. Six formulations were prepared using two polymers. The effect of drug loading and polymeric property on the surface morphology, entrapment efficiency, particle

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Akhter, Sharmin, Shova Paul, Ikramul Hasan, Navid Jubaer Ayon, Syed Shabbir Haider, and Md Selim Reza. "Preparation, Characterization and Compatibility Studies of Naproxen Loaded Microspheres of Cellulosic and Polymethacrylic Polymeric Blend." Dhaka University Journal of Pharmaceutical Sciences 12, no. 1 (2013): 11–21. http://dx.doi.org/10.3329/dujps.v12i1.16295.

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Naproxen, a well-known non-steroidal anti-inflammatory drug was encapsulated with cellulosic and polymethacrylic polymers to provide sustained action and to minimize gastro esophageal side effects by avoiding the release of drug in the upper gastrointestinal tract. Emulsification-solvent evaporation technique using Ethyl Cellulose, Eudragit RSPO and their combination as release retardant was the method of choice. The formulations were prepared by keeping the amount of drug fixed to 1g and the total amount of polymer fixed to 1g in which Ethyl Cellulose and Eudragit RSPO were used in varying co

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Ullah, Md Bashir, Md Rezaul Karim, Md Shamsul Alam, Md Rajib Hassan, Mohiuddin Ahmed Bhuiyan, and Md Sohel Rana. "Formulation and In vitro Evaluation of Unfolding Type Expandable Gastroretentive Film of Enalapril Maleate." Bangladesh Pharmaceutical Journal 20, no. 2 (2018): 148–56. http://dx.doi.org/10.3329/bpj.v20i2.37868.

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The present work was based on the development and characterization of unfolding type gastroretentive dosage form appropriate for controlled release of enalapril maleate. Drug loaded films were prepared by solid dispersion technique using methocel K15 and eudragit RSPO and eudragit RLPO as polymers and polyethylene glycol 400 (PEG 400) as the plasticizer. The film folded in a capsule shell was shown to unfold in the gastric juice and provide drug release up to 12 h in the acidic medium. Formulations provided satisfactory unfolding characteristics allowing expansion to remain in the stomach. For

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8

Saha, Shib Sankar, Mehrina Nazmi, Nandini Saha, and Md Selim Reza. "Preparation and Evaluation of Carbamazepine Sustained Release Tablets." Dhaka University Journal of Pharmaceutical Sciences 11, no. 2 (2013): 173–80. http://dx.doi.org/10.3329/dujps.v11i2.14577.

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The purpose of the present studies was to develop and characterize sustained release tablets of Carbamazepine, an antiepileptic drug. Tablets were prepared by direct compression method. In the formulation, the active drug was taken 200 mg in every formulation. Methocel K4M, Methocel K15M CR, Methocel K100LV CR, Eudragit RSPO and Eudragit RLPO polymers were used as rate retarding agents in twenty four formulations (F-1 to F-24). The effect of hydrophilic polymer PEG 6000 as channeling agent with Methocel K4M was observed in four formulations (F-5 to F-8). The granules were evaluated for angle o

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Partheniadis, Ioannis, Miltiadis Toskas, Filippos-Michail Stavras, Georgios Menexes, and Ioannis Nikolakakis. "Impact of Hot-Melt-Extrusion on Solid-State Properties of Pharmaceutical Polymers and Classification Using Hierarchical Cluster Analysis." Processes 8, no. 10 (2020): 1208. http://dx.doi.org/10.3390/pr8101208.

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The impact of hot-melt extrusion (HME) on the solid-state properties of four methacrylic (Eudragit® L100-55, Eudragit® EPO, Eudragit® RSPO, Eudragit® RLPO) and four polyvinyl (Kollidon® VA64, Kollicoat® IR, Kollidon® SR, and Soluplus®) polymers was studied. Overall, HME decreased Tg but increased electrostatic charge and surface free energy. Packing density decreased with electrostatic charge, whereas Carr’s and Hausner indices showed a peak curve dependency. Overall, HME reduced work of compaction (Wc), deformability (expressed as Heckel PY and Kawakita 1/b model parameters and as slope S′ of

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Verma, P. R. P. "Sustained Release of Theophylline from Eudragit RLPO and RSPO Tablets." Drug Development and Industrial Pharmacy 22, no. 12 (1996): 1243–47. http://dx.doi.org/10.3109/03639049609063244.

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11

Lokhande, A., S. Mishra, R. Kulkarni, and J. Naik. "Effect of Solvents, Drug/Polymer Ratio and Surfactant Concentration on In Vitro Characteristic of Repaglinide Loaded Poly (Meth) Acrylate Nanoparticles." Micro and Nanosystems 6, no. 4 (2015): 241–53. http://dx.doi.org/10.2174/187640290604150302125610.

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In the present work Repaglinide loaded ammonio methacrylate copolymer nanoparticles were developed by modified solvent emulsion technique using high pressure homogenizer. An effect of numerous organic solvents, surfactant concentration, drug-polymer ratios and combination of polymers on encapsulation efficiency as well as drug release profile were studied. Sustained released nanoparticles were obtained in the size of less than 400 nm. FE-SEM showed smooth and rigid surface of Eudragit RS nanoparticle’s while porous surface nature was observed in Eudragit RL nanoparticles. No drug-polymer inter

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Krishnamurthy, B* Yogananda R. Bharathi D. R. "PREPARATION AND CHARACTERIZATION OF POLYMERIC NANOPARTICULATE SYSTEMS CONTAINING ACARBOSE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 06 (2019): 13105–12. https://doi.org/10.5281/zenodo.3257976.

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<em>The present study describes formulation and evaluation of nanoparticulate systems containing Acarbose by using synthetic polymers Eudragit RS 100 and eudragit RSPO for the treatment of type 2 Diabetes mellitus. The prepared Nanoparticles were evaluated for Surface morphology, Drug entrapment efficiency, differential scanning colorimetry, particle size, fourier transform infrared spectroscopy, in-vitro drug release and X-ray diffraction studies. The prepared Nanoparticles are smooth in surface and showing spherical shape. The average particle size of the nanoparticles were found in the rang

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E., Sathish Reddy Meesala. Srinivasa Rao and Mohammed Ibrahim. "FORMULATION AND IN VITRO, IN VIVO EVALUATION OF CEFADROXIL CONTROLLED GASTRORETENTIVE DRUG DELIVERY SYSTEM." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2139–50. https://doi.org/10.5281/zenodo.836461.

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Introduction: Cefadroxil is a first-generation cephalosporin and is very effective against Gram positive and Gram negative infections. Cefadroxil is an antibiotic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional Cefadroxil tablets produce rapid and relatively high peak blood level and require frequent administration to keep the plasma drug level at an effective range. The present study was carried out with an objective of preparation and in vivo evaluation of floating tablets of using Cefadroxil as a model drug using Eudragit polymers to impro

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Maślanka, Anna, Marek Szlósarczyk, Przemysław Talik, et al. "Study of the Effect of Eudragit RSPO on the Photostability of Venlafaxine in a Physical Mixture and in a Melt Form." Processes 11, no. 8 (2023): 2479. http://dx.doi.org/10.3390/pr11082479.

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The effect of Eudragit RSPO on the photostability of venlafaxine in a physical mixture and as a melt was studied. A validated ultra-high-performance liquid chromatography mass spectrometry method was used to determine the content of venlafaxine alongside degradation products. The most likely structures of the degradation products were determined by mass spectrometry. The samples were evaluated before and after exposure to ultraviolet A by differential scanning calorimetry and scanning electron microscopy. The kinetic parameters of the decomposition of venlafaxine in the physical mixture and me

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15

Archana, D. Kajale, and Chandewar AV. "Formulation and evaluation of oral floating In situ gel of Tramadol hydrochloride." Pharmaceutical and Chemical Journal 3, no. 2 (2016): 267–79. https://doi.org/10.5281/zenodo.13754260.

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<em>In situ </em>gel forming systems have been widely investigated as vehicles for sustained drug delivery. <em>In situ </em>gel formation occurs due to one or combination of different stimuli like pH change, temperature modulation and solvent exchange. So, <em>In situ </em>gelling system via different route such as oral, nasal, ophthalmic etc can be formulated. In the present research work Oral Floating Insitu gel of Tramadol Hydrochloride was formulated using Eudragit L100, Eudragit S100, Eudragit RSPO, Ethyl cellulose, HPMC K100M. The optimized batch gave drug release for 12 hrs in the poly

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Dr.E, Hari Krishna T. Mallika *. DS Spandana M. Harika Raj S. Jyothi. "DEVELOPMENT AND EVALUATION OF METFORMIN HCL LOADED EUDRAGIT®RSPO AND EUDRAGIT®RLPO AND GLIMEPIRIDE BILAYER TABLETS." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3371–80. https://doi.org/10.5281/zenodo.1000995.

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The present study was carried out for developing the formulation of Bilayer tablets of Glimepiride, Metformin HCl. Immediate Release (IR) layer was compressed as direct compression method and Sustained Release (SR) layer blends were compressed by wet granulation method. IR and SR layers were evaluated for pre and post compression studies and all studies were found to be within limits. From dissolution data of Glimepiride Immediate release layer, IR5 formulation was shown maximum drug release at 60 min i.e., 96.4%. Hence IR5was concluded as optimised formulation for IR layer. Sustained layer co

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Mohanty, Dibyalochan, Sadaf Jamal Gilani, Ameeduzzafar Zafar, et al. "Formulation and Optimization of Alogliptin-Loaded Polymeric Nanoparticles: In Vitro to In Vivo Assessment." Molecules 27, no. 14 (2022): 4470. http://dx.doi.org/10.3390/molecules27144470.

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The nano-drug delivery system has gained greater acceptability for poorly soluble drugs. Alogliptin (ALG) is a FDA-approved oral anti-hyperglycemic drug that inhibits dipeptidyl peptidase-4. The present study is designed to prepare polymeric ALG nanoparticles (NPs) for the management of diabetes. ALG-NPs were prepared using the nanoprecipitation method and further optimized by Box–Behnken experimental design (BBD). The formulation was optimized by varying the independent variables Eudragit RSPO (A), Tween 20 (B), and sonication time (C), and the effects on the hydrodynamic diameter (Y1) and en

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Dieng, Sidy Mouhamed, Papa Mady Sy, Mamadou Soumboundou, et al. "Stabilization of a Pickering Emulsion by Nanoparticles of Eudragit RSPO and Pol-epsilon Caprolactone: Contact Angle Measurement and Surface Tension Studies." Journal of Pharmaceutical Research International 35, no. 3 (2023): 29–44. http://dx.doi.org/10.9734/jpri/2023/v35i37317.

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The use of colloidal particles to prepare and stabilize emulsions, known as "Pickering emulsions “, has aroused growing interest in recent years. Pickering and Ramsden demonstrated at the beginning of the last century the feasibility of surfactant-free emulsions, in presence of these emulsions is called "Pickering Emulsions". This concept of emulsions stabilized by solid particles is experiencing renewed interest nowadays given the many advantages it offers good stability, environmental protection, user safety, and particle varieties. The first part is devoted to the synthesis of Eudragi

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Sharma, Pooja, Anuj Chawla, and Pravin Pawar. "Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen." Scientific World Journal 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/654829.

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The aim of present investigation deals with the development of time-dependent and pH sensitive press-coated tablets for colon specific drug delivery of naproxen. The core tablets were prepared by wet granulation method then press coated with hydroxypropyl cellulose (HPC) or Eudragit RSPO : RLPO mixture and further coated with Eudragit S-100 by dip immerse method. Thein vitrodrug release study was conducted in different dissolution media such as pH 1.2, 6.8, and 7.4 with or without rat caecal content to simulate GIT conditions. Surface morphology and cross-sectional view of the tablets were vis

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Park, Seong-Jin, Gyu Lin Kim, and Hyo-Kyung Han. "Sustained-Release Solid Dispersions of Fenofibrate for Simutaneous Enhancement of the Extent and Duration of Drug Exposure." Pharmaceutics 16, no. 12 (2024): 1617. https://doi.org/10.3390/pharmaceutics16121617.

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Background/Objectives: A sustained-release formulation of fenofibrate while enhancing drug dissolution with minimal food effect is critical for maximizing the therapeutic benefits of fenofibrate. Therefore, this study aimed to develop an effective solid dispersion formulation of fenofibrate for simultaneous enhancement in the extent and duration of drug exposure. Methods: Fenofibrate-loaded solid dispersions (FNSDs) were prepared using poloxamer 407 and Eudragit® RSPO at varied ratios via solvent evaporation. In vitro/in vivo characteristics of FNSDs were examined in comparison with untreated

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B., Divya* J. Sreekanth D. Satyavati. "FORMULATION AND EVALUATION PARAMETERS OF EXTENDED-RELEASE TABLETS OF ILAPRAZOLE BY USING NATURAL AND SYNTHETIC POLYMERS." Journal of Pharma Research 05, no. 12 (2016): 256–67. https://doi.org/10.5281/zenodo.6413946.

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ABSTRACT Ilaprazole is a Proton Pump Inhibitor (PPI), an anti-acidic drugused in the treatment of dyspepsia, peptic and duodenal ulcer disease, gastroesophageal reflux disease (GERD).Ilaprazole at oral doses of 10 mg has shown higher suppression of gastric acid secretion and more prolonged plasma half-life, and similar safety compared to 20 mg omeprazole. Elimination half-life for Ilaprazole ranged from 4.7 to 5.3 h, Administration of Ilaprazole in an extended-release dosage form would be more desirable by maintaining the plasma drug concentrations at a prolonged period of time. It will be mor

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Kumari, Satish, Anchal Puri, Dhruv Dev, DN Prasad, and ,. Monika. "A review on polymers in natural or modified form used in sustained release tablet." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 870–73. http://dx.doi.org/10.22270/jddt.v9i3-s.2843.

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Tablet is a solid dosage form which is used to deliver the drug to the body to make pharmacological action. The oral dosage form should disperse into small particles to deliver active ingredients in the body, the disperse time of the dosage form depends on the ingredients which are used in the tablet. To make the tablet disintegrate slow usually sustained release agents are used. The sustained release tablets helps in maintaining the drug concentration in the body for the higher time. In this review article various polymers of natural origin and their modified forms are studied, which can be u

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Paul, Shovan, Sharmin Akhter, Ikramul Hasan, Syed Shabbir Haider, and Md Selim Reza. "Encapsulation of Naproxen in Eudragit RSPO Microsphere system: In vitro Characterization and Compatibility Studies." Dhaka University Journal of Pharmaceutical Sciences 11, no. 2 (2013): 147–55. http://dx.doi.org/10.3329/dujps.v11i2.14573.

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The present study has been performed to encapsulate naproxen to provide sustained action and to minimize local side effects by avoiding the drug release in the upper gastrointestinal tract. Naproxen was microencapsulated by oil-in-oil emulsification-solvent evaporation technique using Eudragit RSPO. The formulations were prepared by sequential increase in drug loading ranging from 10% to 70%. In-vitro drug release was studied in a paddle type dissolution apparatus (USP type II) for six hours in phosphate buffer having pH 7.4. At 10% and 70% loading the release were 42.89% and 86.33%, respectiv

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Shivhare, Shubham, Ashutosh Pal Jain, Teena Jain, et al. "Formulation, Development and Characterization of Transdermal Patches of Glipizide." International Journal of Medical Sciences and Pharma Research 8, no. 3 (2022): 1–7. http://dx.doi.org/10.22270/ijmspr.v8i3.47.

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Transdermal patches are innovative drug delivery systems and can be used for achieving efficient systemic effect by passing hepatic first pass metabolism and increasing the fraction absorbed. Like other drugs among the second-generation sulfonylureas, glipizide (GLP) acts by stimulating insulin secretion from pancreatic beta-cells as well as modifying the responsiveness of insulin-sensitive tissues. GLP belongs to biopharmaceutical classification system (BCS) class II and has a low solubility and high permeability. The aim of the current research was to formulate GLP transdermal patches utiliz

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Pandit, Sachin S., Dinesh P. Hase, Manish M. Bankar, Arun T. Patil, and Naresh J. Gaikwad. "Ketoprofen-loaded Eudragit RSPO microspheres: An influence of sodium carbonate onin vitrodrug release and surface topology." Journal of Microencapsulation 26, no. 3 (2008): 195–201. http://dx.doi.org/10.1080/02652040802224793.

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., Yashoda, and Sunita Sonartiya. "Formulation and evaluation of transdermal patches of nitrendipine eudragit RLPO and RSPO using rate controlling polymers." International Journal of Pharmacy and Pharmaceutical Science 4, no. 2 (2022): 52–56. http://dx.doi.org/10.33545/26647222.2022.v4.i2a.88.

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Y., Naveen Kumar*1 Dr. J. Sreekanth2 Dr. P. Vijay Chander Reddy3. "FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF ESOMEPRAZOLE CONTROLLED RELEASE TABLETS BY USING VARIOUS GRADES OF EUDRAGIT POLYMERS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7431–39. https://doi.org/10.5281/zenodo.1006983.

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The aim of the contemporary research work was to develop the controlled release tablets of esomeprazole. Esomeprazole having a shorter biological half life (1-1.5 hours) hence we are selected as a controlled release tablet, So it should be minimize the dose dumping problems and avoid fluctuations in plasma drug concentrations. To maintain constant therapeutic levels of the drug over 24 hours. Compatibility studies was execution during FTIR and DSC shown that there was absence of probable chemical interaction between pure drug and excipients. Controlled release tablets were prepared by direct c

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Gomathi, J., T. Muthukumaran, Kavitha C, Priyanka Sinha, and Sabbathyan Balla. "Formulation and In- Vitro Evaluation of Baclofen Gastroretentive Microballoons for Sustained Drug Delivery." International Journal for Research in Applied Science and Engineering Technology 10, no. 9 (2022): 1322–29. http://dx.doi.org/10.22214/ijraset.2022.46820.

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Abstract: A sustained release drug delivery system for baclofen was designed to increase its residence time in the stomach without establishing contact with the mucosa. This was made possible through the preparation of microballoons by emulsion solvent diffusion-evaporation technique. The prepared microballoons were characterized for physical characteristics such as particle size, particle shape and surface morphology by scanning electron microscopy. Further, percentage yield determination, drug entrapment efficiency, in vitro buoyancy test, micromeritic investigations and in vitro drug releas

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Puttegowda, Venkatesh Dinnekere, Roopa Karki, Divakar Goli, Sajal kumar Jha, and Manjunatha Panduranga Mudagal. "Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats." Scientifica 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/7623193.

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Pravastatin Sodium has a cholesterol lowering agent. It has shorter half-life and undergoes first-pass metabolism. Frequent dose is required in case of conventional dosage form. The purpose of the study is to formulate and evaluate microcapsules containing Pravastatin Sodium by complex with cholestyramine resins coated with Eudragit RLPO and Eudragit RSPO polymers for achieving control release. Complexation of drug on resin was carried out by batch method. Microencapsulation was carried out by nonaqueous solvent evaporation method. Pharmacokinetic studies were done by using rats. The intermedi

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Ansary, Johura, Amit Kumar Chaurasiya, and KM Bashirul Huq. "Formulation and evaluation of metformin HCl floating microspheres." Asian Journal of Medical and Biological Research 1, no. 3 (2016): 396–405. http://dx.doi.org/10.3329/ajmbr.v1i3.26445.

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The purpose of the present investigation was the preparation and evaluation of gastro-retentive floating drug delivery system for anti-diabetic drug metformin hydrochloride that would retain the drug in stomach and continuously release the drug in controlled manner up to a predetermined time leading to improve bioavailability. The microspheres were prepared by oil-in-oil emulsion solvent evaporation technique using ethyl cellulose, methacrylic acid copolymer (Eudragit RS100, Eudragit RSPO and Eudragit RLPO). The dried floating microspheres were evaluated for percentage yield (%), actul drug co

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S K, Swain, Niranjan Patra Patra, Sruti J, and M. E. Bhanoji Rao. "Design and Evaluation of Sustained Release Solid Dispersions of Verapamil Hydrochloride." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 4 (2011): 1252–62. http://dx.doi.org/10.37285/ijpsn.2010.3.4.10.

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The Purpose of this study was to prepare and characterize solid dispersions of this antiarrhythmic drug Verapamil hydrochloride (VPH) with HPMCK4M, EudragitRSPO and their combination with a view to sustain its dissolution properties. Investigation of the properties of the prepared solid dispersions were performed using release studies and Fourier transform infrared (FT-IR). The results obtained showed that the rate of dissolution of Verapamil hydrochloride was considerably more sustained when formulated in solid dispersions with HPMCK4M and Eudragit RSPO as compared with pure drug and physical

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Saha, Nandini, Ikramul Hasan, Mehrina Nazmi, and Md Selim Reza. "Design and Development of Sustained Release Microspheres of Ibuprofen by Emulsification Solvent Evaporation Method Using Polymeric Blend." Bangladesh Pharmaceutical Journal 16, no. 1 (2013): 39–44. http://dx.doi.org/10.3329/bpj.v16i1.14489.

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Ibuprofen, a non-steroidal anti-inflammatory drug was formulated as microspheres by using Methocel K4M & Eudragit RSPO. These microspheres were prepared by emulsification solvent evaporation method to provide sustained action and to minimize local side effect of Ibuprofen by avoiding the drug release in the upper gastrointestinal tract. The prepared microspheres were subjected to various evaluation and in-vitro release studies. In-vitro drug release was studied in a paddle type dissolution apparatus (USP Type II Dissolution Apparatus) using Phosphate buffer (pH 7.4) as the dissolution medi

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Monika, ,., Jagdeep Singh Dua, D. N. Prasad, Mansi Hans, and Satish Kumari. "Preparation and Characterization of Itraconazole Microsponges using Eudragit RSPO and Study the Effect of Stirring on the Formation of Microsponges." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 451–58. http://dx.doi.org/10.22270/jddt.v9i3-s.2879.

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The purpose of the present study was to prepare and evaluate Itraconazole loaded microsponges using Eudragit for the controlled release of the drug and study the effect of stirring rate on the formation of microsponges. Microsponges containing Itraconazole were prepared by using quasi-emulsion solvent diffusion method at different stirring rate i.e. 500, 800, 1000, 1200 and 1500rpm. Particle size of prepared microsponge was observed in the range of 78.43 to 23.18 µm. Scanning electron microscopy revealed the porous, spherical nature of the microsponges. The production yield, entrapment efficie

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Patel, S. S., M. R. Patel, and M. J. Patel. "Formulation and Evaluation of Microsponge Based Nicorandil Sustained Released Tablet." Journal of Scientific Research 9, no. 3 (2017): 285–96. http://dx.doi.org/10.3329/jsr.v9i3.31193.

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The aim of the present work was to develop once-daily sustained release microsponges formulations of Nicorandil, a potent potassium channel opener used in cardiovascular diseases and it has low oral bioavailability (70%) and half-life 1 h. So, it is good candidate for sustained release formulations based on microsponge technology. The microsponges were prepared by using quasi-emulsion solvent diffusion method. Scanning Electron Microscopy (SEM) revealed that the microsponges of nicorandil with Eudragit - RSPO and HPMC K100M were smooth, porous, glossy and discrete spherical. The actual drug co

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Ho, Hoang Nhan, and Thi Thao Ngoc Phan. "Development of an in situ gel containing tinidazole-loaded polymeric nanoparticles for oral cavity administration." Tạp chí Y Dược Huế 15, no. 2 (2025): 180–86. https://doi.org/10.34071/jmp.2025.2.25.

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Background: Tinidazole (TNZ) demonstrates greater efficacy against anaerobic bacteria, particularly Gram-negative strains, compared to metronidazole. Nanosizing TNZ and incorporating it into in situ gel formulations for topical periodontitis treatment offers several advantages. Objectives: This study aimed to formulate an in situ gel containing preformed Eudragit RSPO-based nanoparticles (NPs) of TNZ and to evaluate its physicochemical properties. Materials and methods: Poloxamer 407 was used as a thermosensitive gelling agent, either alone or in combination with other gelling agents. The in s

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Chaturvedi, Priyanka, Anurag Singh, Payal Agrawal, and Surendra Jain. "USING THE BOX–BEHNKEN EXPERIMENTAL DESIGN DEVELOPMENT OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERES OF SIMVASTATIN BY SPRAY DRYING METHOD." INDIAN DRUGS 57, no. 10 (2021): 65–70. http://dx.doi.org/10.53879/id.57.10.12475.

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Simvastatin is an antihyper-lipidemic drug which inhibits HMG-CoA reductase, interrupting cholesterol synthesis. It is poorly water soluble drug having very low bioavailability (5%). It is having better absorption in upper gastro intestinal tract. Due to lower bioavailability and short biological half-life simvastatin is prescribed 2-3 times a day which leads to lower patient compliance. The aim of the present work was to prepare controlled release microspheres which and retained in the gastric area by adhering to the mucosal membrane for longer period of time. It was a also proposed to design

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D., V. Chaudhary* S.D. Pande &. .N. G. Dumore. "DESIGN AND CHARACTERIZATION OF POLYMERIC MICROSPHERES FOR ORAL ADMINISTRATION." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 4, no. 7 (2017): 26–38. https://doi.org/10.5281/zenodo.835676.

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An appropriately designed sustained or controlled release drug delivery system can be a major advance towards solving the problem associated with the existing drug delivery system. Microspheres as a novel drug delivery system for oral administration are having the feasibility of carrying the drug. These are the monolithic spheres or therapeutic agent distributed throughout the matrix as a molecular dispersion of particles. Rational behind the drug encapsulation into microspheres is preparation of suitable formulation with longer duration of action for control release thereby sustaining the rol

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Puri, Vinam, Riya Savla, Kevin Chen, Keyaara Robinson, Amitkumar Virani, and Bozena Michniak-Kohn. "Antifungal Nail Lacquer for Enhanced Transungual Delivery of Econazole Nitrate." Pharmaceutics 14, no. 10 (2022): 2204. http://dx.doi.org/10.3390/pharmaceutics14102204.

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The fungal disease of the nail, onychomycosis, which is also the most prevalent nail disturbance, demands effective topical treatment options considering the possible adverse effects of systemic antifungal therapy. The current work is focused on development of an adhesive and resistant, drug-delivering and permeation-enhancing polymeric film containing econazole nitrate (ECN) for topical antifungal treatment. The development of the lacquer formulation was guided by the Quality by Design approach to achieve the critical quality attributes needed to obtain the product of desired quality. Eudragi

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T, Mamatha, Sama M, and Husna K. Qureshi. "Development and Evaluation of Mesalamine—Glutamine Cocrystal Tablets for Colon Specific Delivery." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 5 (2017): 3866–74. http://dx.doi.org/10.37285/ijpsn.2017.10.5.8.

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 The objective of the work was to develop the co-crystal formulation of mesalamine with glutamine. It was done to enhance dissolution rate, solubility and physicochemical properties to be used in pharmaceutical composition (tablet) for colon targeting. Co-crystal preparation was carried out by liquid assisted grinding method using glutamine as a co-crystal former (1:1 stoichiometric ratio) and acetonitrile as a solvent giving maximum solubility and dissolution rate. The formation of the co-crystals was confirmed by Fourier Transform – Infra Red spectrometry, Differential Scanning Calorim

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H. Hussain, Ahmed, and Yehia I.Khalil. "Some Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 17, no. 1 (2017): 1–6. http://dx.doi.org/10.31351/vol17iss1pp1-6.

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An inert matrix that is used to control the release of (PTX) was prepared using Eudragit RL100 and RSPM types as matrix forming agent . The matrices were prepared by either dry granulation(slugging) , or wet granulation method using chloroform as a solvent evaporation vehichle. The cumulative release was adjusted by using polyvinylpyrollidone (PVP) or ethylcellulose (EC) polymers .The results indicated that both methods of preparation were valid for incorporation PTX as a sustained release granules .Moreover ,the results revealed that best polymer used was Eudragit RSPM in 3:20 polymer drug ra

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Abdel Rahman, Aly, A. Aboutaleb, A. Stamm, S. Abdel Rahman, and E. Samy. "ACCELERATED STABILITY TESTING OF IBUPROFEN-EUDRAGIT RSPM SUSTAINED RELEASE TABLETS USING 1H-NMR, HPLC AND TLC." Bulletin of Pharmaceutical Sciences. Assiut 16, no. 1 (1993): 1–11. http://dx.doi.org/10.21608/bfsa.1993.70021.

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Cetin, Emel Oyku, Evren Gundogdu, and Levent Kirilmaz. "Novel microparticle drug delivery systems based on chitosan and Eudragit®RSPM to enhance diltiazem hydrochloride release property." Pharmaceutical Development and Technology 17, no. 6 (2011): 741–46. http://dx.doi.org/10.3109/10837450.2011.580759.

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AMIN, MILIND J., KEYUR S. PATEL, DEEPA R. PATEL, ZIL P. PATEL, and JAYANTI V. BAJAG. "FORMULATION AND EVALUATION OF SUSTAINED-RELEASE PELLETS OF LORNOXICAM." International Journal of Applied Pharmaceutics, July 7, 2021, 221–27. http://dx.doi.org/10.22159/ijap.2021v13i4.41601.

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Objective: The aim of the study was to develop sustained release pellets of lornoxicam using Eudragit RLPO and Eudragit RSPO to reduce the dosing frequency. Methods: The sustained release pellets of lornoxicam were prepared by extrusion–spheronization technique using Eudragit RLPO and Eudragit RSPO as release retardant polymers and microcrystalline cellulose as spheronizing agent. A 32 Full factorial design was applied to investigate the combined effect of the two independent variables i.e. concentration of Eudragit RLPO (X1) and concentration of Eudragit RSPO (X2) on the dependent varia

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Shreeya, M. S. *. Mrs. Jyothi M. Dr.Chandrakala.V Rashmi G. "FORMULATION AND IN VITRO EVALUATION OF GASTRORETENTIVE EXPANDABLE FILM OF ENALAPRIL MALEATE WITH DIFFERENT EUDRAGIT POLYMERS." August 31, 2023. https://doi.org/10.5281/zenodo.8305336.

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<em>The present study illustrates the formulation and in vitro evaluation of gastroretentive expandable film of Enalapril maleate. These films were prepared using Enalapril maleate, Eudragit RSPO and RL 100, HPMC, dichloromethane, ethanol and PEG 400 by solvent evaporation technique. Five different formulations were prepared with individual and combination of two Eudragit polymers. The evaluation parameters of the polymeric films comprising two different property Eudragit polymers were studied. These formulations were subjected to unfolding behavior which showed 10 to 15 mins.In-vitro drug rel

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Sy, Papa Mady. "NANOCOMPOSITES A MATRICE EUDRAGIT POUR LA LIBERATION CONTROLEE ET CONTINUE DU KETOPROFENE." Dakar Medical 69, no. 1 (2025). https://doi.org/10.61585/pud-dkm-v69n109.

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Introduction : Aujourd’hui, une nouvelle famille de polymères chargés a apparu. Ces polymères, seuls ou en association avec des nano-objets (nanoparticules), sont capables de modifier la libération des principes actifs dansdes formes pharmaceutiques appelées nanocomposites. L’objectif général de ce travail est de réaliser des nanocomposites à matrice Eudragitâ pour la libération contrôlée et continue du kétoprofène. Matériel et méthodes : Le choix de de la carboxyméthylcellulose (CMC) comme principal excipient est justifié par le fait que ce dernier soit un matériau biocompatible. Nous avons a

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Daslaniya, Dhiren, Manish Patel, and Amarish Shah. "DESIGN, DEVELOPMENT AND CHARACTERIZATION OF EXTENDED RELEASE MULTIUNIT PARTICULATE SYSTEM OF ANTI-INFLAMMATORY DRUG." International Journal of Pharmaceutical Sciences and Drug Research, July 1, 2009, 100–102. https://doi.org/10.25004/ijpsdr.2009.010209.

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Multi unit particulate system has long been employed to improve the bioavailability of drugs. Mesalamine pellets were prepared by Coating drug solution on sugar sphere followed by various functional coating. The influence of rate controlling membrane made up of Eudragit RSPO and Eudragit RLPO in combination with delay release polymer coating with Eudragit L100 in different proportions on drug release kinetics was studied. Pellets were for the various parameter like Physical characteristics, assay and in-vitro dissolution profile. The study confirmed that mesalamine can be delivered by multi un

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K. Deepika, M. Sai Vishnu, and A. Lakshmana Rao. "Development and Evaluation of Controlled Release Formulations of Esomeprazole." International Journal of Research in AYUSH and Pharmaceutical Sciences, December 26, 2021, 536–52. http://dx.doi.org/10.47070/ijraps.v5i5.115.

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The present work was aimed to development of controlled release formulations of Esomeprazole to improve bioavailability. Esomeprazole is the proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity. Construction of calibration curve of Esomeprazole and to investigate the drug and polymer interaction studies by FTIR and DSC. To prepare the different controlled release formulations of Esomepraz

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Yadav, Vishal D., Dipali S. Salunkhe, and Vasant Y. Lokhande. "Multiparticulate Drug Delivery of Losartan Potassium via Extrusion-Spheronization: Formulation and Dissolution Comparisons." BIO Integration 5, no. 1 (2024). http://dx.doi.org/10.15212/bioi-2024-0079.

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Abstract Background: Losartan potassium, an antihypertensive medication, has high solubility and a short half-life that result in potential adverse effects and rapid drug clearance. Multiparticulate drug delivery systems enhance the drug’s bioavailability, decrease patient-to-patient variability, and optimize drug distribution. Herein, losartan potassium pellets for sustained drug release were developed and characterized. Methods: The formulation process involved varying the concentrations of Eudragit RSPO (200 mg, 400 mg, or 600 mg) and Eudragit L100 (200 mg, 400 mg, or 600 mg) across nine pe

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Anukumar, E* Nagaraja T. S. Yogananda R. Maruthi N. "PREPARATION AND EVALUATION OF NANOPARTICLES CONTAINING ANTI-HYPERTENSIVE DRUG BY SONICATION METHOD." July 1, 2022. https://doi.org/10.5281/zenodo.6786294.

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The present study describes preparation and evaluation of nanoparticulate systems containing losartan potassium by using polymers eudragit RS100 and eudragit RSPO by sonication method (Probe sonicator) for the treatment of hypertension to increase the oral bioavailability. The prepared Nanoparticles were evaluated for Surface morphology, Drug entrapment efficiency, Differential scanning colorimetry, particle size, FTIR, in-vitro drug release and stability studies. The prepared Nanoparticles are smooth in surface and showing spherical shape and average particle size of the Nanoparticles were fo

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Kamlesh, J. Wadher1. "Formulation and Evaluation of Sustained Release Matrix Tablets of Metformin Hydrochloride Using pH Dependent and pH Independent Methacrylate Polymers." April 8, 2011. https://doi.org/10.5281/zenodo.8633.

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Metformin hydrochloride is recommended globally as first line therapy due to its favorable profile on morbidity and mortality associated with type-2 diabetes mellitus. However, limitations of multiple dosing and risk of triggering gastrointestinal symptoms make its dose optimization difficult. Extended-release metformin matrix tablets were prepared by direct compression of drug and different pH-dependent (Eudragit L-100 and S-100) and pH-independent (Eudragit RLPO and RSPO) polymer combinations. The influence of varying the polymer/polymer (w/w) ratio was evaluated. Among the different examine

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