Relevant bibliographies by topics / Eudragit / Dissertations / Theses
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Dissertations / Theses on the topic 'Eudragit'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Frank, Luiza Abrahão. "Avaliação da performance e caracterização in vitro de diferentes hidrogéis de quitosana contendo nanocápsulas poliméricas para aplicação vaginal." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/144066.

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A via de administração vaginal pode ser considerada uma alternativa para diversos tratamentos, tanto de ação farmacológica local como sistêmica. No entanto, o tempo de permanência do fármaco no local da aplicação e a eficácia esperada representam um desafio para o desenvolvimento de formulações. O objetivo deste trabalho foi desenvolver nanocápsulas de superfície catiônica (EUDRAGIT® RS 100) ou aniônica (EUDRAGIT® S 100), contendo ou não o marcador de fluorescência Vermelho do Nilo como um modelo de fármaco lipofílico, e incorporar essas partículas em hidrogéis de quitosana, a fim de aumentar
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2

Souza, Marina Claro de. "Microencapsulação do sulfóxido de albendazol: uma estratégia para otimização da terapia das parasitoses." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-21032009-094902/.

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As parasitoses causadas por helmintos constituem um grave problema sanitário, tanto para os seres humanos quanto para os animais, além de gerar grandes prejuízos econômicos. O sulfóxido de albendazol é um fármaco anti-helmíntico de amplo espectro, largamente utilizado na medicina veterinária, veiculado pelas vias oral e parenteral, mediante a utilização de formas farmacêuticas convencionais. Apresenta biodisponibilidade baixa e irregular em função de sua pouca solubilidade nos fluidos biológicos. Para a manutenção da concentração plasmática e completa eliminação dos parasitos, são necessárias
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3

Wagner, Karl Gerhard. "Tablettierung überzogener Pellets auf einer Hochleistungsrundlauftablettenpresse unter Einsatz von Eudragit FS 30 D /." [S.l. : s.n.], 1999. http://www.gbv.de/dms/bs/toc/309513251.pdf.

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4

Albers, Jessica. "Hot-melt extrusion with poorly soluble drugs." Göttingen Cuvillier, 2008. http://d-nb.info/990809501/04.

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5

Mandal, Bivash. "Preparation and Physicochemical Characterization of Eudragit® RL100 Nanosuspension with potential for Ocular Delivery of Sulfacetamide." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271430956.

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6

Socha, Marie. "Apport des nanotechnologies dans le domaine des peptides et des protéines : Application à l’absorption par voie orale et à la furtivité." Thesis, Nancy 1, 2008. http://www.theses.fr/2008NAN10118/document.

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Les nanoparticules constituent une forme médicamenteuse d’avenir dans le domaine pharmaceutique. Capables de véhiculer de nombreux principes actifs, elles peuvent les libérer dans l’organisme après administration in vivo mais aussi les piloter vers des cibles prédéfinies. Ce travail repose sur la préparation, par une technique de double émulsion, de nanoparticules constituées de deux polymères : la poly-e-caprolactone et un polymère polyacrylique et polycationique (Eudragit® RS). La première partie a consisté en la mise au point de nanoparticules encapsulant de l’insuline et capables de la lib
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7

Schichtel, Julian [Verfasser]. "Determination of the dissolution behavior of celecoxib-eudragit E 100-nanoparticles using cross-flow filtration / Julian Schichtel." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1122860242/34.

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8

Verones, Daniel Antonio Garbim. "Desenvolvimento de micropartículas gastro-resistentes contendo azitromicina por spray-drying." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-17112010-232035/.

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A azitromicina é um antibiótico da classe dos macrolídeos utilizado principalmente no tratamento de infecções de pele e do trato respiratório. Suas propriedades farmacocinéticas lhe conferem ampla distribuição e acumulação tecidual. Devido à sua baixa biodisponibilidade (37%) e instabilidade ao pH ácido, foram investigadas alternativas para o desenvolvimento de microparticulados com propriedade gastro-resistente para aplicação em diferentes formas farmacêuticas. As micropartículas de azitromicina foram obtidas pela técnica de secagem por pulverização (spray-drying) com o polímero pH-dependente
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9

Marais, Etienne Barend. "Permeation of excised intestinal tissue by insulin released from Eudragit® L100/Trimethyl chitosan chloride microspheres /E.B. Marais." Thesis, North-West University, 2013. http://hdl.handle.net/10394/9676.

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The purpose of this research project was to develop and characterise matrix type microspheres prepared from Eudragit® L100, containing insulin as model peptide drug as well as an absorption enhancer, N-trimethyl chitosan chloride (TMC), to improve intestinal absorption via the paracellular route. Insulin loaded microspheres were prepared using a single water in oil emulsification/evaporation method in accordance with a fractional factorial design (23) and subsequently characterised in terms of morphology as well as internal structure. Also, insulin and TMC loading were determined using a high
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10

Zafar, Nadiah. "Microparticules biodégradables à morphologie éponge pour applications thérapeutiques et cosmetotextile." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1068/document.

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L'objectif de cette thèse est de préparer et de caractériser les particules cationiquesbiodégradables à base de cyclodextrine. Ces microparticules doivent également presenter unestructure et morphologie éponge et multifonctionnelle. L'encapsulation simultanée deplusieurs actifs cosmétiques (bien etre) et thérapeutiques (anti-inflammatoire) dans cesmicroparticules peut ouvrir de nouvelles applications une fois appliquées sur un textilespécifiquement sélectionnés pour leur fonctionnalisation. Pour atteindre cet objectif, desmicroparticules à base de polyméthacrylate cationique ont été préparés e
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11

Bharaj, Satinder Singh. "Development of Extended Release Dextromethorphan Matrix Tablets." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1121780418.

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12

Dalcin, Ana Júlia Figueiró. "DESENVOLVIMENTO, CARACTERIZAÇÃO E AVALIAÇÃO DA ATIVIDADE ANTIMICROBIANA E ANTIBIOFILME DE NANOCÁPSULAS DE DIHIDROMIRICETINA EM CATETERES URINÁRIOS." Centro Universitário Franciscano, 2015. http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/543.

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Submitted by MARCIA ROVADOSCHI (marciar@unifra.br) on 2018-08-16T20:20:00Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_AnaJuliaFigueiroDalcin.pdf: 1880693 bytes, checksum: 994407ff94e18668a6d303e7d72b7fd6 (MD5)<br>Made available in DSpace on 2018-08-16T20:20:00Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_AnaJuliaFigueiroDalcin.pdf: 1880693 bytes, checksum: 994407ff94e18668a6d303e7d72b7fd6 (MD5) Previous issue date: 2015-08-28<br>Nosocomial infections associated with
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Ribas, Daniele Adriane. "DESENVOLVIMENTO DE NANOCÁPSULAS CONTENDO CETOPROFENO E AVALIAÇÃO in vitro DA CITOTOXICIDADE." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/5989.

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The aim of this work was to prepare, characterize and evaluate the in vitro cytotoxicity of Eudragit S100® nanocapsules (NC) containing ketoprofen. The nanostructured suspensions were prepared in triplicate by the method of interfacial deposition of preformed polymer. Caprilic/capric triglyceride or rosehip oil were used as the oil core in the preparation of such formulations. Previously, tests of swelling/dissolution of the films of Eudragit S100® were performed and showed the feasibility of using both oils as the core of the NC. The results of the physico-chemical characterization of the sys
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14

Pires, Deivid William. "Influência do omeprazol sobre processos de dissolução e desintegração gástrica de comprimidos pH-dependente." Botucatu, 2020. http://hdl.handle.net/11449/192189.

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Orientador: José Ricardo de Arruda Miranda<br>Resumo: A via oral de administração de fármacos é a mais utilizada devido a maior aceitação pelo paciente e sua fácil administração. Dentre as estratégias de sistema de liberação de fármacos estão os comprimidos revestidos com polímero pH-dependente, da qual o Eudragit E-100 é um polímero de revestimento protetor solúvel em pH <5, utilizado em formas farmacêuticas sólidas para liberação do fármaco no ambiente gástrico. Para que ocorra a liberação do fármaco é necessário que o comprimido revestido passe por processos que antecedem a absorção, tal co
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15

Silva, Acarilia Eduardo da. "Micropart?culas polim?ricas ? base de xilana e Eudragit? S-100 contendo mesalazina visando ? libera??o c?lon-espec?fica." Universidade Federal do Rio Grande do Norte, 2009. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13451.

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Made available in DSpace on 2014-12-17T14:16:25Z (GMT). No. of bitstreams: 1 AcariliaES_Dissert_01.pdf: 1640327 bytes, checksum: 9c4568aff953d538d26000691eb0407d (MD5) Previous issue date: 2009-03-10<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Colon-specific drug delivery systems have attracted increasing attention from the pharmaceutical industry due to their ability of treating intestinal bowel diseases (IBD), which represent a public health problem in several countries. In spite of being considered a quite effective molecule for the treatment of IBD, mesalazine (5-
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16

Vinner, Gurinder K. "Engineering bacteriophage encapsulation processes to improve stability and controlled release using pH responsive formulations." Thesis, Loughborough University, 2018. https://dspace.lboro.ac.uk/2134/35524.

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Enteric pathogens form a large part of infectious diseases which contribute to a bulk of the healthcare costs. Enteric infections are usually contracted via the faecal-oral route or through contact with contaminated surfaces. Treatment by antibiotics is becoming increasingly ineffective due to the growing number of antibiotic resistant strains. Anti-microbial resistance poses a serious threat to the future of healthcare worldwide and necessitates the search for alternate forms of therapy. Bacteriophages (phages), are viruses which specifically infect and lyse bacteria. To introduce phages as a
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17

Santos, Lidiane dos. "Preparação e avaliação de cápsulas gastro-resistentes de diclofenaco de sódio." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2005. http://hdl.handle.net/10183/6922.

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Cápsulas resistentes ao trato gastrintestinal são freqüentemente usadas com diversos propósitos. Estas cápsulas promovem eficácia farmacológica e farmacocinética de substâncias que são instáveis, ou irritantes para a mucosa gástrica. O diclofenaco de sódio é um antiinflamatório não-esteróide, que, por ser muito utilizado, despertou o interesse do setor magistral para sua manipulação. Porém, o fármaco é irritante para a mucosa gástrica, havendo necessidade de se empregar substâncias capazes de proteger o meio gástrico da ação do medicamento e uma alternativa para o setor magistral é a manipulaç
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18

SARANG, SANJAY S. "METHACRYLATE AND Ca-ALGINATE POLYMERS AS BARRIER COATINGS FOR PROTECTION AND CONTROLLED RELEASE OF VITAMIN C." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1078246935.

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19

Al-Shammaa, Zaid. "Targeting Drug-Resistant Tuberculosis Using SMART Nanotechnology Approach." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439310613.

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20

Pather, Sathasivan Indiran. "An investigation of the production of non-coated sustained release beads by extrusion and Spheronization." University of the Western Cape, 1995. http://hdl.handle.net/11394/8457.

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Doctor Pharmaceuticae - DPharm<br>The popularity and increasing complexity of sustained release dosage forms has resulted in increased costs to the patient. One approach to achieve cheaper, yet effective, sustained release medication is through the simplification of production processes. Matrix tablets have been used to sustain the release of numerous drugs and are cheap to prepare. Since they are single-unit dosage forms, however, they display less predictable transit through the gastrointestinal tract. Hence, they provide less reliable blood levels of the drug in comparison with multi partic
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21

Jara, González Miguel Orlando. "Análisis sistemático de variables determinantes en la producción de nanopartículas poliméricas de Eudragit® RS, RL y PCL por el método de nanoprecipitación." Tesis, Universidad de Chile, 2016. http://repositorio.uchile.cl/handle/2250/144706.

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Memoria para optar al título de Químico Farmacéutico<br>En los últimos años la mayoría de los fármacos producidos por la industria farmacéutica innovadora presentan problemas de solubilidad acuosa, lo que reduce la biodisponibilidad de estos y dificulta su formulación. Una opción para vehiculizar estos fármacos es mediante el uso de la nanotecnología utilizando matrices poliméricas. Para la generación de nanopartículas poliméricas, el método de nanoprecitación es una opción interesante, ya que es simple, rápido, escalable y utiliza materiales poco tóxicos. Sin embargo, su principal limitante e
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22

Stangarlin, Mônica Fabiele Lorensi. "Avaliação da influência do óleo e do polímero sobre as características físico-químicas e estabilidade de sistemas nanoestruturados contendo ubiquinona." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/6048.

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This work evaluated the influence of the composition on the physico-chemical characteristics, stability and photostability of nanostructures containing ubiquinone. Nanocapsules (NC) and nanoemulsions (NE) were prepared by interfacial deposition of preformed polymers and spontaneous emulsification, respectively. The formulations were characterized and compared in relation to the influence of the oil (argan or linseed oil) and its amount in the formulation (3% or 1.5%), the type of polymer (poli(ε-caprolactone), PCL or Eudragit® RL100, EUD), drug presence, besides the comparison between both nan
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23

Verwey, Werner Jaun. "Influence of modified release excipients on ketoprofen release from chitosan particles / W.J. Verwey." Thesis, North-West University, 2005. http://hdl.handle.net/10394/1034.

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Controlled release formulations offer many advantages over conventional dosage forms. These include reduced plasma fluctuations and improved patient comp1i:nce. Complex controlled release formulations such as those with enteric release properties, often require additional steps in the production phase. The costs and economic impact associated with these complex controlled release dosage formulations often outweigh the immediate benefits. Thus the development of an economic method to produce controlled release particles is of great importance especially in third world countries. In controlled r
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24

Devevey, Delphine. "Enrobage gastro-résistant à base d'eudragit L 30 D-55 de comprimés oblongs." Paris 5, 1995. http://www.theses.fr/1995PA05P149.

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Lyra, Amanda Martinez. "DESENVOLVIMENTO, CARACTERIZAÇÃO E AVALIAÇÃO IN VIVO DE SISTEMAS DE LIBERAÇÃO MICROPARTICULADOS CONTENDO EFAVIRENZ." UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2016. http://tede2.uepg.br/jspui/handle/prefix/93.

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Made available in DSpace on 2017-07-21T14:13:05Z (GMT). No. of bitstreams: 1 Amanda Lyra.pdf: 6099284 bytes, checksum: 8701070289c9fd679c58cb469286e18a (MD5) Previous issue date: 2016-02-17<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The efavirenz is the first choice drug of non-nucleoside reverse transcriptase inhibitors used in the treatment of HIV-1 infections. It belongs to class II of the Biopharmaceutics Classification System and your therapeutic dose is of 600 mg, taken before bedtime due the side effects. With the aim of improve the drug’s bioavailability with p
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Syzov, Vladyslav. "Delivery of a coated bioactive from a rumen controlled-release device." The University of Waikato, 2008. http://hdl.handle.net/10289/2368.

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Ruminants possess a unique digestive system. Using the high metabolic potential of the symbiotic microflora of the rumen, ruminants are capable of digesting plant material and obtaining nutrients and energy from this process. Because of the ruminal fermentation, the most bioactives are not stable in the harsh ruminal environment. Therefore there is a need to improve the bioavailability of a bioactive by protecting it from the ruminal digestion. The formulation of protected bioactive can be delivered in the rumen in a controlled manner and over a long period of time. In this project the degree
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27

Pontes, Thales Renan Ferreira. "Desenvolvimento de sistema magn?tico polim?rico contendo antimicrobianos para tratamento de infec??es por Helicobacter pylori." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br:8080/jspui/handle/123456789/18296.

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Made available in DSpace on 2015-02-24T17:42:52Z (GMT). No. of bitstreams: 1 ThalesRFP_DISSERT.pdf: 5363462 bytes, checksum: 16f2d3a123870a2d8c63de00ac4bf689 (MD5) Previous issue date: 2014-02-24<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Helicobacter pylori is the main cause of gastritis, gastroduodenal ulcer disease and gastric cancer. The most recommended treatment for eradication of this bacteria often leads to side effects and patient poor compliance, which induce treatment failure. Magnetic drug targeting is a very efficient method that overcomes these drawbacks
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Lobão, Paulo Alexandre Lourenço. "Desenvolvimento e caracterização de comprimidos de libertação prolongada de captopril." Doctoral thesis, Porto : [Edição do Autor], 2004. http://hdl.handle.net/10216/64007.

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Lobão, Paulo Alexandre Lourenço. "Desenvolvimento e caracterização de comprimidos de libertação prolongada de captopril." Tese, Porto : [Edição do Autor], 2004. http://catalogo.up.pt/F?func=find-b&local_base=UPB01&find_code=SYS&request=000096002.

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30

Souza, Tatiane Pereira de. "Desenvolvimento tecnológico e otimização de formas farmacêuticas sólidas contendo alto teor de produto seco por aspersão de Phyllanthus niruri L. (Euphorbiaceae)." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2004. http://hdl.handle.net/10183/147061.

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Phyllanthus niruri é largamente utilizada na medicina tradicional, principalmente, para o tratamento de cálculos renais. Estudos farmacológicos comprovam sua eficácia e segurançaa terapêutica, sugerindo os polifenóis, presentes na sua constituição química, como possíveis responsáveis por esta atividade biológica. Estes dados concedem a esta espécie qualidades favoráveis para o planejamento de um medicamento fitoterápico. Nesse sentido, foi inicialmente ideada uma forma farmacêutica sólida. Para tanto foi desenvolvido e validado um método analítico por cromatografia líquida de alta eficiência (
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GALLI, GIULIA. "THE EUDRACT 2017-004494-13 TRIAL ON THYMIC EPITHELIAL TUMORS: THE PARADIGM OF A COMPREHENSIVE STUDY FOR A RARE DISEASE." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/931345.

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Li, Dan. "Microencapsulation of protein with EUDRAGIT S 100 polymer." Thesis, 2005. http://hdl.handle.net/2440/37986.

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Lactose intolerance is a common and inconvenient medical condition and can cause severe discomfort. People who experience lactose intolerance often take lactase enzyme supplements when they wish to consume dairy products. As a consequence, they normally consume dairy products that are rendered lactose free or else a lactase enzyme supplement is taken concurrently. Normally, these are pills or tablets that dissolve and release the enzyme in the stomach. However, the enzyme may be denatured in the low pH conditions of stomach. Hence, a higher dose is required to ensure that an effective concentr
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Li, Dan. "Microencapsulation of protein with EUDRAGIT S 100 polymer." 2005. http://hdl.handle.net/2440/37986.

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Lactose intolerance is a common and inconvenient medical condition and can cause severe discomfort. People who experience lactose intolerance often take lactase enzyme supplements when they wish to consume dairy products. As a consequence, they normally consume dairy products that are rendered lactose free or else a lactase enzyme supplement is taken concurrently. Normally, these are pills or tablets that dissolve and release the enzyme in the stomach. However, the enzyme may be denatured in the low pH conditions of stomach. Hence, a higher dose is required to ensure that an effective concentr
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Hurbans, Nivriti. "Formulation and evaluation of modified release eudragit® matrices containing diclofenac sodium." Thesis, 1998. http://hdl.handle.net/10413/4688.

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The aim of the present study was to formulate oral modified release matrices of diclofenac sodium, using the Eudragit® polymers. In addition to the formulation processes, numerous variables had to be investigated, which included dissolution variables, formulation variables, and processing variables. The application of the tabletting technique as well as the use of Eudragit® polymers to modify the release of diclofenac sodium is motivated at the outset. A comprehensive review of modified drug release, the use of the tabletting methodologies and the application of Eudragit® polymers are presente
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Khamanga, S. M. M., N. Parfitt, T. Nyamuzhiwa, H. Haidula, and Roderick Walker. "The evaluation of Eudragit microcapsules manufactured by solvent evaporation using USP Apparatus 1." 2009. http://hdl.handle.net/10962/d1006310.

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The objectives of this study were to prepare microcapsules containing verapamil and propranolol and to evaluate the kinetics and mechanism of drug release from the microcapsules using USP Apparatus 1. The effects of polymer concentration and polymer type on the cumulative amount of drug released were evaluated. The microcapsules were manufactured using Eudragit RS and RL polymers by solvent evaporation with the ultimate aim of prolonging drug release. Twenty-four formulations were prepared using different drug/polymer ratios. The effects of polymer type and polymer/drug ratios on the size, flo
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Dias, Tiago André Malacho. "Effect of plasticisers on the pH-dependency of an eudragit based drug delivery system." Master's thesis, 2014. http://hdl.handle.net/10451/38741.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>With the advent of new drug delivery systems, various drug molecules have been revived of their therapeutic and commercial benefits. Polymers have played an indispensable role in this advancement, facilitating the development of systems which deliver the drug at desired site of action in optimum therapeutic concentration. Eudragit polymers, for example, have received special attention. Methacrylic acid Eudragit polymers have been the focus of numerous studies due to their pHdep
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Bruce, Caroline Dietzsch 1976. "Recrystallization of guaifenesin from hot-melt extrudates containing Acryl-EZE® or Eudragit® L100-55." Thesis, 2008. http://hdl.handle.net/2152/3851.

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The physical stability of guaifenesin in melt-extruded acrylic matrix tablets was investigated. The initial study found that recrystallization was caused by guaifenesin supersaturation in Eudragit[Trademark] L100-55, and that the instability was confined to tablet surfaces. Drug release was not affected by crystal growth as guaifenesin is very water soluble. The addition of a polymer in which guaifenesin showed a higher solubility to the matrix blend decreased recrystallization on storage as supersaturation levels dropped. The second investigation identified heterogeneous nucleation as an addi
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Liao, Chao Ming, and 廖昭銘. "Characterization of Drug-Polymer Interaction and Effect on the Preparation and Release Mechanism of Theophylline/ Eudragit L Microcapsules." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/91585966655399918045.

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Lu, Jian-Liang, and 盧建良. "Eudragit-Coated Pill Filled with Freeze-Dried Folic Acid-Chitosan/Alginate Nanoparticles for Photodynamic Detection of Colon Cancer." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/07078092552842430744.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>100<br>Colorectal cancer is the third common cancer in Taiwan, and the most common histologic type is adenomatous polyposis. Removing adenomatous polyps in earlier stage by surgery can reduce the mortality efficaciously. Colonoscopy is a common way to discover the dysplasia of colonic tissues directly. But some small adenomatous polyps or cancers in early-stage could be easily missed during endoscopy examinations due to the little differences between normal tissues and cancerous tissue. The main aim of this study was to prepared an oral formulation for protected nan
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Graça, Diogo Filipe Amaro Santana. "Biological effects of acrylic engineered particulate-systems." Master's thesis, 2014. http://hdl.handle.net/10362/13943.

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Polymeric particulate-systems are of great relevance due to their possible biomedical applications, among them as carriers for the nano- or microencapsulation of drugs. However, due to their unique specific properties, namely small size range, toxicity issues must be discarded before allowing its use on health-related applications. Several polymers, as poly(methyl methacrylate) (PMMA), have proved to be suitable for the preparation of particulate-systems. However, a major drawback of its use refers to incomplete drug release from particles matrix. Recent strategies to improve PMMA release pro
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Schilling, Sandra Ursula. "Implications of plasticization on the properties of hot-melt extruded oral dosage forms." 2009. http://hdl.handle.net/2152/7527.

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The influence of plasticization and other formulation factors on the properties of hot-melt extruded dosage forms for the controlled release of water-soluble active compounds was investigated. Citric acid monohydrate was demonstrated to function as a solid-state plasticizer in hot-melt extruded Eudragit® RS PO tablets and in cast films when concentrations below the compatibility limit were employed. Melting of the organic acid and solubilization in the polymer during extrusion were necessary to observe the plasticizing effect. The release rate of diltiazem hydrochloride, used as a high-melting
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Malode, V. N., Anant R. Paradkar, and P. V. Devarajan. "Controlled release floating multiparticulates of metoprolol succinate by hot melt extrusion." 2015. http://hdl.handle.net/10454/7336.

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Yes<br>We present hot melt extrusion (HME) for the design of floating multiparticulates. Metoprolol succinate was selected as the model drug. Our foremost objective was to optimize the components Eudragit® RS PO, polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) to balance both buoyancy and controlled release. Gas generated by sodium bicarbonate in acidic medium was trapped in the polymer matrix to enable floating. Eudragit® RS PO and PEO with sodium bicarbonate resulted in multiparticulates which exhibited rapid flotation within 3 minutes but inadequate total floating time (TF
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Costa, Ana Margarida Paulo da. "Estudo da libertação de compostos adsorvidos em polímeros pH-responsivos." Master's thesis, 2015. http://hdl.handle.net/1822/47507.

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Dissertação de mestrado integrado em Engenharia Biológica (área de especialização em Tecnologia Química e Alimentar)<br>O desenvolvimento de aplicações e sistemas de libertação controlada emerge como uma área bastante promissora, surgindo nesse âmbito a aposta na utilização de polímeros responsivos capazes de responder às necessidades específicas de cada pessoa e de cada situação. A presente dissertação foi desenvolvida no âmbito do estágio realizado no CeNTI – Centro de Nanotecnologia e Materiais Técnicos, Funcionais e Inteligentes. Dentro da área de investigação dos materiais funcionais
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Santos, Joana Sofia Silva. "Nanotoxicology: study of nanomaterials’genotoxic effects in cell lines." Master's thesis, 2015. http://hdl.handle.net/10451/20858.

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Tese de mestrado, Biologia (Biologia Humana e Ambiente), Universidade de Lisboa, Faculdade de Ciências, 2015<br>Nos dias de hoje, surge cada vez mais a necessidade de se recorrer a uma maior qualidade e quantidade de variados produtos, para que seja possível responder ao rápido crescimento da população. Assim desenvolvem-se novas tecnologias, das quais, uma das mais recentes é a utilização de nanomateriais (NMs) em diversas áreas, como na cosmética, alimentação, biomedicina, indústria, entre outras, designando-se assim de NMs manufaturados (produzidos deliberadamente pelo Homem). Os NMs contêm
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