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Academic literature on the topic 'Euploidie'

Author: Grafiati

Published: 14 December 2022

Last updated: 28 January 2023

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Journal articles on the topic "Euploidie"

1

Schmidt, Joana. "Ovarielle Stimulation beeinflusst nicht Euploidie- und Lebendgeburtrate." gynäkologie + geburtshilfe 25, no. 5 (October 2020): 18. http://dx.doi.org/10.1007/s15013-020-3141-7.

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Gazzo, Eduardo, Fernando Peña, Federico Valdez, Arturo Chung, Claudio Bonomini, Mario Ascenzo B., Marcelo Velit, and Ernesto Escudero. "El uso de la tecnología Time-Lapse y algoritmo predictivo KIDScore 5 ayudan a mejorar la selección de embriones euploides para la transferencia." Revista Peruana de Ginecología y Obstetricia 65, no. 2 (May 9, 2019): 189–95. http://dx.doi.org/10.31403/rpgo.v65i2173.

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Objetivos. Evaluar si el uso del algoritmo KIDScore 5 (known implantation data) puede ayudar a seleccionar entre los embriones euploides, para mejorar las tasas de embarazo e implantación en pacientes sometidas a procedimientos de reproducción asistida. Métodos. Estudio de cohorte retrospectivo en una clínica de fertilidad, desde octubre 2016 a diciembre 2018. Se estudió 1 049 embriones provenientes de 328 pacientes. Todos los embriones fueron cultivados en la incubadora Time-Lapse, Embryoscope® (Vitrolife®, Canadá) durante 5 a 6 días. De estos, 896 embriones (85,4%) fueron biopsiados y analizados mediante NGS y recibieron una valoración otorgada por el algoritmo predictivo KIDScore 5 (Vitrolife®, Canadá). Los 153 embriones restantes (14,6%) únicamente recibieron la valoración mediante el algoritmo predictivo KIDScore 5. Se realizó 256 transferencias únicas de embriones euploides en parejas sometidas a tratamientos de FIV en el laboratorio de reproducción asistida de la Clínica Inmater, Lima – Perú. Resultados. La tasa de implantación de los embriones euploides transferidos con valores de KIDScore = 6 versus los transferidos con valores de KIDScore = 1 tuvo diferencia estadísticamente signficativa (73,5% vs. 50,8%; p=0,030). Al evaluar la relación entre la tasa de euploidia embrionaria versus el resultado del valor de KIDScore 5, se obtuvo diferencias altamente significativas en las tasas de euploidia en los embriones con resultados de KIDScore 6 y 5 versus los de KIDScore 0 y 1 (60,5% vs. 45,7%; p=0,0004). Conclusiones. La selección embrionaria con ayuda del algoritmo KIDScore 5 ofrece ventaja en las tasas de implantación y embarazo únicamente cuando se transfieren embriones euploides. Su uso como criterio adicional a la selección embrionaria debiera ser considerado siempre que se acompañe estudio genético a los embriones a transferir. Los embriones euploides con valor más alto en la escala del algoritmo KIDScore 5, tienen mejores tasas de implantación y euploidía que los embriones con el valor mínimo de dicho algoritmo.

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Irani, M., C. Canon, A. Robles, B. Maddy, V. Gunnala, X. Qin, C. Zhang, K. Xu, and Z. Rosenwaks. "No effect of ovarian stimulation and oocyte yield on euploidy and live birth rates: an analysis of 12 298 trophectoderm biopsies." Human Reproduction 35, no. 5 (April 29, 2020): 1082–89. http://dx.doi.org/10.1093/humrep/deaa028.

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STUDY QUESTION Does ovarian stimulation affect embryo euploidy rates or live birth rates (LBRs) after transfer of euploid embryos? SUMMARY ANSWER Euploidy rates and LBRs after transfer of euploid embryos are not significantly influenced by gonadotropin dosage, duration of ovarian stimulation, estradiol level, follicle size at ovulation trigger or number of oocytes retrieved, regardless of a woman’s age. WHAT IS KNOWN ALREADY Aneuploidy rates increase steadily with age, reaching >80% in women >42 years old. The goal of ovarian stimulation is to overcome this high aneuploidy rate through the recruitment of several follicles, which increases the likelihood of obtaining a euploid embryo that results in a healthy conceptus. However, several studies have suggested that a high response to stimulation might be embryotoxic and/or increase aneuploidy rates by enhancing abnormal segregation of chromosomes during meiosis. Furthermore, a recent study demonstrated a remarkable difference in euploidy rates, ranging from 39.5 to 82.5%, among young oocyte donors in 42 fertility centres, potentially suggesting an iatrogenic etiology resulting from different stimulation methods. STUDY DESIGN, SIZE, DURATION This is a retrospective cohort study that included 2230 in vitro fertilisation (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) cycles and 930 frozen-thawed single euploid embryo transfer (FET) cycles, performed in our centre between 2013 and 2017. PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 12 298 embryos were analysed for ploidy status. Women were divided into five age groups (<35, 35–37, 38–40, 41–42 and >42 years old). Outcomes were compared between different durations of stimulation (<10, 10–12 and ≥13 days), total gonadotropin dosages (<4000, 4000–6000 and >6000 IU), numbers of oocytes retrieved (<10, 10–19 and ≥20 oocytes), peak estradiol levels (<2000, 2000–3000 and >3000 pg/mL), and sizes of the largest follicle on the day of trigger (<20 and ≥20 mm). MAIN RESULTS AND THE ROLE OF CHANCE Within the same age group, both euploidy rates and LBRs were comparable between cycles regardless of their differences in total gonadotropin dosage, duration of stimulation, number of oocytes harvested, size of the largest follicles or peak estradiol levels. In the youngest group, (<35 years, n = 3469 embryos), euploidy rates were comparable between cycles with various total gonadotropin dosages (55.6% for <4000 IU, 52.9% for 4000–6000 IU and 62.3% for >6000 IU; P = 0.3), durations of stimulation (54.4% for <10 days, 55.2% for 10–12 days and 60.9% for >12 days; P = 0.2), number of oocytes harvested (59.4% for <10 oocytes, 55.2% for 10–19 oocytes and 53.4% for ≥20 oocytes; P = 0.2), peak estradiol levels (55.7% for E2 < 2000 pg/mL, 55.4% for E2 2000–3000 pg/mL and 54.8% for E2 > 3000 pg/mL; P = 0.9) and sizes of the largest follicle (55.6% for follicles <20 mm and 55.1% for follicles ≥20 mm; P = 0.8). Similarly, in the oldest group (>42 years, n = 1157 embryos), euploidy rates ranged from 8.7% for gonadotropins <4000 IU to 5.1% for gonadotropins >6000 IU (P = 0.3), from 10.8% for <10 days of stimulation to 8.5% for >12 days of stimulation (P = 0.3), from 7.3% for <10 oocytes to 7.4% for ≥20 oocytes (P = 0.4), from 8.8% for E2 < 2000 pg/mL to 7.5% for E2 > 3000 pg/mL (P = 0.8) and from 8.2% for the largest follicle <20 mm to 8.9% for ≥20 mm (P = 0.7). LBRs after single FET were also comparable between these groups. LIMITATIONS, REASONS FOR CAUTION Although this large study (2230 IVF/PGT-A cycles, 12 298 embryos and 930 single FET cycles) demonstrates the safety of ovarian stimulation in terms of aneuploidy and implantation potential of euploid embryos, a multi-centre study may help to prove the generalisability of our single-centre data. WIDER IMPLICATIONS OF THE FINDINGS These findings reassure providers and patients that gonadotropin dosage, duration of ovarian stimulation, estradiol level, follicle size at ovulation trigger and number of oocytes retrieved, within certain ranges, do not appear to significantly influence euploidy rates or LBRs, regardless of the woman’s age. STUDY FUNDING/COMPETING INTEREST(S) No external funding was received and there are no competing interests to declare. TRIAL REGISTRATION NUMBER N/A

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Rao, Durga Gedela, Krishna Chaitanya Mantravadi, and Vijay Kumar Sharanappa. "Euploid Day-5 Blastocysts Versus Euploid Day-6 Blastocysts — Will the Reproductive Outcomes Differ? An Observational Study." Fertility & Reproduction 03, no. 02 (June 2021): 42–48. http://dx.doi.org/10.1142/s2661318221500055.

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Background and objective: Day-5 blastocyst embryos are usually chosen for assisted reproductive therapy. We compared the reproductive outcomes of the euploid blastocysts developed on Day 5 versus Day 6. Methods: This single-center, retrospective observational study analyzed patients aged 25–45 years, who underwent intracytoplasmic sperm injection from December 2014 to November 2018. Depending on the day of trophectoderm biopsy, patients were categorized into Day-5 and Day-6 groups. Percentages of euploid embryos were calculated for both groups, and elective single euploid blastocysts were transferred in a frozen embryo transfer (FET) cycles. The study endpoints were the comparisons of the reproductive outcomes including clinical pregnancy rate (CPR), implantation rate (IR), miscarriage rate (MR), and live birth rate (LBR) between Day-5 and Day-6 euploid FET groups. Results: A total of 801 embryos from 184 patients were evaluated [Day 5 ([Formula: see text]=769); Day 6 ([Formula: see text]=32); 42.45% were euploid] with the rate of euploidy in Day-5 and Day-6 groups at 42.52% and 40.62%, respectively. A total of 126 patients underwent FET with 126 elective single euploid embryos (Day 5: 117; Day 6: 9). For Day-5 versus Day-6 groups, a significantly higher IR (61.54% vs. 44.44%; [Formula: see text] = 0.0531), CPR (61.54% vs. 44.44%; [Formula: see text] = 0.0531), and LBR (61.54% vs. 33.33%; [Formula: see text] = 0.0014) were reported. Multivariate analysis on ANOVA suggested, comparable pregnancy rates at Day 5 and Day 6 ([Formula: see text] = 0.728). Conclusions: Day-5 euploid blastocysts seem to offer better reproductive outcomes than Day-6 euploid blastocysts. Further research is recommended to evaluate the reproductive outcomes of Day-6 blastocysts.

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Merhi, Zaher, Serin Seckin, and Marco Mouanness. "Intraovarian platelet-rich plasma administration could improve blastocyst euploidy rates in women undergoing in vitro fertilization." Clinical and Experimental Reproductive Medicine 49, no. 3 (September 1, 2022): 210–14. http://dx.doi.org/10.5653/cerm.2021.05057.

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Objective: Platelet-rich plasma (PRP) therapy has received a considerable attention as an adjunct to fertility treatments, especially in women with very low ovarian reserve and premature ovarian insufficiency. Although recent studies have demonstrated that PRP led to improvements in folliculogenesis and biomarkers of ovarian reserve, the effect of intraovarian PRP administration on embryo genetics has not been studied.Methods: We report a pilot study of patients who had preimplantation genetic testing for aneuploidy (PGT-A) before and then within 3 months following PRP administration. Twelve infertile women with at least one prior failed in vitro fertilization (IVF) cycle underwent ovarian stimulation (cycle 1) with a gentle stimulation protocol and PGT-A performed at the blastocyst stage. Following cycle 1, autologous intraovarian PRP administration was performed. Within 3 months following PRP administration, the patients underwent cycle 2 and produced blastocysts for PGT-A. The percentage of euploid embryos between both cycles was compared.Results: The mean age of all participants was 40.08±1.46 years, and their mean body mass index was 26.18±1.18 kg/m2. The number of good-quality embryos formed at the blastocyst stage was similar between cycle 1 and cycle 2 (3.08±0.88 vs. 2.17±0.49, respectively; p=0.11). Among all patients in cycle 1, 3 of 37 embryos were euploid (8.11%) while in cycle 2, 11 out of 28 embryos were euploid (39.28%, p=0.002). Three clinical pregnancies were noted among this patient group.Conclusion: This novel study is the first to present an improvement in the embryo euploidy rate following intraovarian PRP application in infertile women with prior failed IVF cycles. The growth factors present in PRP may exhibit a local paracrine effect that could improve meiotic aberrations in human oocytes and thus improve euploidy rates. Whether PRP improves live birth rates and lowers miscarriage rates remains to be determined in large trials.

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Bayram, A., I. Elkhatib, A. Arnanz, A. Linan, F. Ruiz, B. Lawrenz, and H. M. Fatemi. "What Drives Embryo Development? Chromosomal Normality or Mitochondria?" Case Reports in Genetics 2017 (2017): 1–4. http://dx.doi.org/10.1155/2017/4397434.

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Objective. To report the arrest of euploid embryos with high mtDNA content. Design. A report of 2 cases. Setting. Private fertility clinic. Patients. 2 patients, 45 and 40 years old undergoing IVF treatment. Interventions. Mature oocytes were collected and vitrified from two ovarian stimulations. Postthaw, survived mature oocytes underwent fertilization by intracytoplasmic sperm injection (ICSI). Preimplantation genetic screening (PGS) and mitochondrial DNA (mtDNA) copy number were done using next generation sequencing (NGS). The only normal embryo among the all-biopsied embryos had the highest “Mitoscore” value and was the only arrested embryo in both cases. Therefore, the embryo transfer was cancelled. Main Outcome Measures. Postthaw survival and fertilization rate, embryo euploidy, mtDNA copy number, and embryo development. Results. In both patients, after PGS only 1 embryo was euploid. Both embryos had the highest mtDNA copy number from all tested embryos and both embryos were arrested on further development. Conclusions. These cases clearly demonstrate the lack of correlation between mtDNA value (Mitoscore) and chromosomal status of embryo.

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Kusaba, Yuki, Akira Otsuka, Huanghuang Dai, Shigeki Inaba, and Hiroshi Kitagaki. "Induction of Chromosomal Aneuploids from Brewery Shochu Yeast with Novel Brewery Characteristics." Fermentation 8, no. 2 (January 30, 2022): 62. http://dx.doi.org/10.3390/fermentation8020062.

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The first development method of brewery shochu yeast focusing on chromosomal aneuploidy is reported in this study. Euploidy diploid shochu yeast S-3 was treated with a microtubule inhibitor, nocodazole, for the purpose of inducing aneuploidy. Next, 2,3,5-triphenyl tetrazolium chloride (TTC) staining and the growth rate were investigated to select aneuploids. Aneuploids were selected at a frequency of 8.2 × 10−4, which was significantly higher than that of the control group, mainly at chromosomes I, II, III, IX, XII, XIII, and XVI. The acquired aneuploids were evaluated for their metabolic and brewing characteristics. A hierarchical cluster analysis based on endogenous metabolite data discriminated euploid S-3 and aneuploids. In addition, principal-component analysis of the constituents of the broth brewed with the strains discriminated between euploid S-3 and aneuploids. Sensory evaluation of the broth brewed with euploid S-3 and aneuploids showed that it tended to differ in aroma and taste. Specific ethanol production rates of the aneuploids were not deteriorated. The method of this selection made it possible to efficiently obtain aneuploids with various brewing characteristics from brewer’s yeast, which do not correspond to genetically modified organisms. This novel breeding method focusing on chromosomal aneuploidy will facilitate the development of novel shochu yeast strains.

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Gultom, Tumiur. "PENGARUH PEMBERIAN KOLKISIN TERHADAP JUMLAH KROMOSOM BAWANG PUTIH (Allium sativum) LOKAL KULTIVAR DOULU." JURNAL BIOSAINS 2, no. 3 (December 1, 2016): 165. http://dx.doi.org/10.24114/jbio.v2i3.4959.

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Bawang putih lokal kultivar Doulu berasal dari Desa Doulu Kabupaten Karo Sumatera Utara. Bawang putih lokal Doulu dikenal luas oleh masyarakat di Sumatera Utara karena rasa yang pedas dan aromanya yang tajam. Jumlah kromosom bawang putih lokal ini sebanyak 16 =2n. Penelitian ini bertujuan untuk mengetahui pengaruh kolkisin terhadap jumlah kromosom bawang putih (Allium sativum) pada konsentrasi dan lama waktu perendaman yang berbeda. Metode yang digunakan dalam penelitian ini adalah metode eksperimen dengan menggunakan metode squash. Rancangan percobaan yang digunakan adalah percobaan faktorial dengan dua faktor perlakuan. Faktor pertama adalah dosis pemberian larutan konsentrasi kolkisin (D) dengan 3 taraf yaitu : 0,1% (D1), 0,2% (D2), dan 0,3% (D3). Faktor kedua adalah lama waktu perendaman (T) dengan 4 taraf perlakuan yaitu 6 jam (T1), 12 jam (T2), 18 jam (T3), dan 24 jam (T4). Hasil penelitian menunjukkan bahwa kromosom bertambah secara euploid dan aneuploidi yang menyebabkan terbentuknya sel-sel poliploidi. Tipe-tipe poliploidi yang terbentuk yang ditemukan yaitu euploidi yang tetraploid (4n) pada perlakuan D1T2, D2T3 dan D3T4. Kromosom yang bertambah secara aneuploid yaitu 2n + 4 pada perlakuan D2T2, 2n + 6 pada perlakuan D1T1; 3n + 6 pada perlakuan D1T3 dan D1T4 ; 4n + 1 pada perlakuan D2T1 dan T3D3; 4n +8 pada perlakuan D3T2; 5n +8 pada perlakuan D3T1 dan 6n +4 pada perlakuan D2T4. Kata kunci: Kolkisin, metode squash, poliploid, aneuploid, euploidi.

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Cimadomo, Danilo, Antonio Capalbo, Lisa Dovere, Luisa Tacconi, Daria Soscia, Adriano Giancani, Emiliano Scepi, et al. "Leave the past behind: women’s reproductive history shows no association with blastocysts’ euploidy and limited association with live birth rates after euploid embryo transfers." Human Reproduction 36, no. 4 (February 20, 2021): 929–40. http://dx.doi.org/10.1093/humrep/deab014.

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Abstract STUDY QUESTION Is there an association between patients’ reproductive history and the mean euploidy rates per biopsied blastocysts (m-ER) or the live birth rates (LBRs) per first single vitrified-warmed euploid blastocyst transfers? SUMMARY ANSWER Patients’ reproductive history (as annotated during counselling) showed no association with the m-ER, but a lower LBR was reported after euploid blastocyst transfer in women with a history of repeated implantation failure (RIF). WHAT IS KNOWN ALREADY Several studies have investigated the association between the m-ER and (i) patients’ basal characteristics, (ii) ovarian stimulation strategy and dosage, (iii) culture media and conditions, and (iv) embryo morphology and day of full blastocyst development. Conversely, the expected m-ER due to women’s reproductive history (previous live births (LBs), miscarriages, failed IVF cycles and transfers, and lack of euploid blastocysts among prior cohorts of biopsied embryos) still needs investigations. Yet, this information is critical to counsel new patients about a first cycle with preimplantation genetic testing for aneuploidy (PGT-A), but even more so after former adverse outcomes to prevent treatment drop-out. STUDY DESIGN, SIZE, DURATION This observational study included all patients undergoing a comprehensive chromosome testing (CCT)-based PGT-A cycle with at least one biopsied blastocyst in the period April 2013-December 2019 at a private IVF clinic (n = 2676 patients undergoing 2676 treatments and producing and 8151 blastocysts). m-ER were investigated according to women’s reproductive history of LBs: no/≥1, miscarriages: no/1/>1; failed IVF cycles: no/1/2/>2, and implantation failures after previous transfers: no/1/2/>2. Among the 2676 patients included in this study, 440 (16%) had already undergone PGT-A before the study period; the data from these patients were further clustered according to the presence or absence of euploid embryo(s) in their previous cohort of biopsied blastocysts. The clinical outcomes per first single vitrified-warmed euploid blastocyst transfers (n =1580) were investigated according to the number of patients’ previous miscarriages and implantation failures. PARTICIPANTS/MATERIALS, SETTING, METHODS The procedures involved in this study included ICSI, blastocyst culture, trophectoderm biopsy without hatching in Day 3, CCT-based PGT-A without reporting segmental and/or putative mitotic (or mosaic) aneuploidies and single vitrified-warmed euploid blastocyst transfer. For statistical analysis, Mann–Whitney U or Kruskal–Wallis tests, as well as linear regressions and generalised linear models among ranges of maternal age at oocyte retrieval were performed to identify significant differences for continuous variables. Fisher’s exact tests and multivariate logistic regression analyses were instead used for categorical variables. MAIN RESULTS AND THE ROLE OF CHANCE Maternal age at oocyte retrieval was the only variable significantly associated with the m-ER. We defined five clusters (<35 years: 66 ± 31%; 35–37 years: 58 ± 33%; 38–40 years: 43 ± 35%; 40–42 years: 28 ± 34%; and >42 years: 17 ± 31%) and all analyses were conducted among them. The m-ER did not show any association with the number of previous LBs, miscarriages, failed IVF cycles or implantation failures. Among patients who had already undergone PGT-A before the study period, the m-ER did not associate with the absence (or presence) of euploid blastocysts in their former cohort of biopsied embryos. Regarding clinical outcomes of the first single vitrified-warmed euploid blastocyst transfer, the implantation rate was 51%, the miscarriage rate was 14% and the LBR was 44%. This LBR was independent of the number of previous miscarriages, but showed a decreasing trend depending on the number of previous implantation failures, reaching statistical significance when comparing patients with >2 failures and patients with no prior failure (36% versus 47%, P < 0.01; multivariate-OR adjusted for embryo quality and day of full blastocyst development: 0.64, 95% CI 0.48–0.86, P < 0.01). No such differences were shown for previous miscarriage rates. LIMITATIONS, REASONS FOR CAUTION The sample size for treatments following a former completed PGT-A cycle should be larger in future studies. The data should be confirmed from a multicentre perspective. The analysis should be performed also in non-PGT cycles and/or including patients who did not produce blastocysts, in order to investigate a putative association between women’s reproductive history with outcomes other than euploidy and LBRs. WIDER IMPLICATIONS OF THE FINDINGS These data are critical to counsel infertile couples before, during and after a PGT-A cycle, especially to prevent treatment discontinuation due to previous adverse reproductive events. Beyond the ‘maternal age effect’, the causes of idiopathic recurrent pregnancy loss (RPL) and RIF are likely to be endometrial receptivity and selectivity issues; transferring euploid blastocysts might reduce the risk of a further miscarriage, but more information beyond euploidy are required to improve the prognosis in case of RIF. STUDY FUNDING/COMPETING INTEREST(S) No funding was received and there are no competing interests. TRIAL REGISTRATION NUMBER N/A.

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Coll, Lluc, Mònica Parriego, Montserrat Boada, Marta Devesa, Gemma Arroyo, Ignacio Rodríguez, Bonaventura Coroleu, Francesca Vidal, and Anna Veiga. "Transition from blastomere to trophectoderm biopsy: comparing two preimplantation genetic testing for aneuploidies strategies." Zygote 26, no. 3 (May 25, 2018): 191–98. http://dx.doi.org/10.1017/s0967199418000084.

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SummaryShortly after the implementation of comprehensive chromosome screening (CCS) techniques for preimplantation genetic testing for aneuploidies (PGT-A), the discussion about the transition from day 3 to blastocyst stage biopsy was initiated. Trophectoderm biopsy with CCS is meant to overcome the limitations of cleavage-stage biopsy and single-cell analysis. The aim of this study was to assess the results obtained in our PGT-A programme after the implementation of this new strategy. Comparisons between the results obtained in 179 PGT-A cycles with day 3 biopsy (D+3) and fresh embryo transfer, and 204 cycles with trophectoderm biopsy and deferred (frozen–thawed) embryo transfer were established. Fewer embryos were biopsied and a higher euploidy rate was observed in the trophectoderm biopsy group. No differences in implantation (50.3% vs. 61.4%) and clinical pregnancy rate per transfer (56.1% vs. 65.3%) were found. Although the mean number of euploid embryos per cycle did not differ between groups (1.5 ± 1.7 vs. 1.7 ± 1.8), the final number of euploid blastocysts available for transfer per cycle was significantly higher in the trophectoderm biopsy group (1.1 ± 1.3 vs. 1.7 ± 1.8). This factor led to an increased cumulative live birth rate in this last group (34.1% vs. 44.6%). Although both strategies can offer good results, trophectoderm biopsy offers a more robust diagnosis and the intervention is less harmful for the embryos so more euploid blastocysts are finally available for transfer and/or vitrification.

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Dissertations / Theses on the topic "Euploidie"

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Cooper, Jennifer L. "Gene expression analysis of Sucrose synthase1 and Shrunken1 in euploid and aneuploid maize /." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3025614.

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Goldschmid, Dominik [Verfasser], and Karl-Oliver [Akademischer Betreuer] Kagan. "Sonographische Messung der Sphenofrontalen Distanz sowie der Maxillalänge bei euploiden und aneuploiden Feten / Dominik Goldschmid ; Betreuer: Karl-Oliver Kagan." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1213720583/34.

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Villanueva, Zúñiga Pamela Esperanza. "Influencia de la edad paterna en el desarrollo embrionario y euploidía, en tratamientos de fecundación in vitro con ovodonación y diagnóstico genético preimplantacional por FISH o A-CGH, en dos centros privados de fertilidad asistida, 2008-2013." Doctoral thesis, Universidad Nacional Mayor de San Marcos, 2016. https://hdl.handle.net/20.500.12672/8728.

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Determina la influencia de la edad paterna en el desarrollo embrionario y euploidía, utilizando ciclos de Fecundación in vitro (FIV), con ovodonación y genética preimplantacional, por hibridación fluorescente in situ (FISH, de fluorescence in situ hybridization) o por hibridación genómica comparada (a-CGH, de array- comparative genomic hybridization). El presente estudio es de tipo analítico de cohortes retrospectivas. Se incluyeron 613 ciclos de ovodonación con genética preimplantacional, en la modalidad de screening (PGS). Se clasificó a la población en 2 cohortes, en función a la edad paterna: cohorte 1, no expuestos, <40 años (n= 231); cohorte 2, expuestos, ≥ de 40 años (n= 382). Los datos fueron recolectados de la base de datos computarizada de los dos Centros de FIV. Los resultados son en cuanto al desarrollo embrionario, la tasa de fecundación normal, resulta significativamente mayor en el grupo 1 (76.93%) que en el grupo 2 (73.96%) (p=0.0073). Asimismo, la tasa de falla de fecundación, es afectada significativamente por la edad paterna (p=0.028), resultando en 18.21% y 16.08% en los grupos 2 y grupo 1, respectivamente. La tasa de blastulación es significativamente menor en el grupo 2, 41.84% vs 45.78%, encontrado en varones de menor edad (p=0.0071). No se encontraron diferencias en la tasa de fecundación anormal y la calidad embrionaria en día 3, entre los grupos de estudio. Por otro lado, no se encontró diferencias en la tasa de euploidía embrionaria, determinada por FISH ni por aCGH, entre los dos grupos. Se concluye que el incremento de la edad paterna, afecta el desarrollo embrionario hasta blastocisto y la morfología, pero no la euploidía de los embriones.
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Books on the topic "Euploidie"

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Sills, E. Scott, ed. Screening the Single Euploid Embryo. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16892-0.

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Kemkemer, Claus. Functional analysis of X-chromosomal gene expression in Drosophila melanogaster. 2011.

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Sills, E. Scott. Screening the Single Euploid Embryo: Molecular Genetics in Reproductive Medicine. Springer, 2015.

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Sills, Eric Scott. Screening the Single Euploid Embryo: Molecular Genetics in Reproductive Medicine. Springer, 2015.

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Sills, E. Scott. Screening the Single Euploid Embryo: Molecular Genetics in Reproductive Medicine. Springer, 2016.

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Book chapters on the topic "Euploidie"

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Mehlhorn, Heinz. "Euploidy." In Encyclopedia of Parasitology, 968. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_4617.

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Mehlhorn, Heinz. "Euploidy." In Encyclopedia of Parasitology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_4617-1.

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Delhanty, Joy D. A. "The Development of PGD." In Screening the Single Euploid Embryo, 1–4. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16892-0_1.

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Ahlström, Aisling, Alison Campbell, Hans Jakob Ingerslev, and Kirstine Kirkegaard. "Prediction of Embryo Viability by Morphokinetic Evaluation to Facilitate Single Transfer." In Screening the Single Euploid Embryo, 133–45. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16892-0_10.

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Devjak, Rok, Tanja Burnik Papler, and Eda Vrtacnik Bokal. "Utilisation of Transcriptome-Based Biomarkers for Single Embryo Transfer." In Screening the Single Euploid Embryo, 147–61. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16892-0_11.

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Barahona, Paulette, Don Leigh, William Ritchie, Steven J. McArthur, and Robert P. S. Jansen. "Array CGH and Partial Genome Sequencing for Rapidly Karyotyping IVF Blastocysts Before Single Transfer." In Screening the Single Euploid Embryo, 163–78. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16892-0_12.

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Harton, Gary L., and Dagan Wells. "Current and Future Preimplantation Genetic Screening (PGS) Technology: From Arrays to Next-Generation Sequencing." In Screening the Single Euploid Embryo, 179–91. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16892-0_13.

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Treff, Nathan R., Eric J. Forman, and Richard T. Scott. "SNP Array, qPCR, and Next-Generation Sequencing-Based Comprehensive Chromosome Screening." In Screening the Single Euploid Embryo, 193–202. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16892-0_14.

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Kuliev, Anver, Svetlana Rechitsky, and Oleg Verlinsky. "Expanding PGD Applications to Nontraditional Genetic and Non-genetic Conditions." In Screening the Single Euploid Embryo, 203–15. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16892-0_15.

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Sills, E. Scott, Xiang Li, Daniel A. Potter, Jane L. Frederick, and Charlotte D. Khoury. "Should Molecular Cytogenetic Techniques Be Applied to Facilitate Single Embryo Transfer in Egg Donation Cases? Assessment of Frequency and Distribution of Embryo Aneuploidy After Anonymous Donor Oocyte IVF." In Screening the Single Euploid Embryo, 217–29. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16892-0_16.

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Conference papers on the topic "Euploidie"

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Heimbecker, Vivian. "ASSOCIAÇÃO ENTRE A OBESIDADE E ABORTOS DE EMBRIÕES EUPLOIDES." In II Congresso Brasileiro de Biologia Molecular On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2330.

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Introdução: A obesidade é definida pela apresentação de um índice de massa corporal (IMC) ≥ 30 kg/m². É considerada uma doença crônica associada a doenças cardiovasculares, diabetes tipo 2 e câncer, por exemplo, levando a maiores taxas de morbidade e mortalidade. Quanto à relação com a fertilidade, tem-se que homens e mulheres obesos apresentam menores taxas de concepção. Também nas mulheres, a obesidade contribui para menores taxas de implantação oocitária, gravidez e números de nascidos vivos por fertilização in vitro (FIV). Objetivos: Explorar a literatura a respeito da associação entre abortos euploides e a obesidade feminina. Material e métodos: Trata-se de uma revisão de literatura de artigos em língua inglesa das bases de dados PubMed e Biblioteca Virtual em Saúde (BVS) publicados nos últimos 10 anos. Outro critério de inclusão adotado foi apresentar os termos “obesity”, “euploid” e “miscarriage” no título ou resumo. Foram excluídos trabalhos que não seguiram os critérios anteriores. Resultados: Perda de gravidez recorrente de embrião euploide é vinculada a polimorfismos de genes de susceptibilidade múltipla e fatores de estilo de vida, como idade, hábito de fumar e obesidade. Abortos no primeiro trimestre de gestação normalmente são atribuídos a embriões aneuploides, entretanto, abortos euploides foram relacionados ao IMC em pacientes que passaram por algum procedimento de FIV e Teste Genético Pré-Implantacional para Aneuploidias (PGT-A). Mulheres magras (IMC 18,5 – 24,9 kg/m²) apresentaram menores taxas de aborto (14%) do que as com sobrepeso (29%) ou obesas (42%). Entre as obesas, também houve chance 56% maior de aborto euploide do que em mulheres não obesas. Conclusão: A partir dos resultados, conclui-se que mulheres obesas sofrem mais abortos do que as não obesas. Também é possível inferir que abortos ligados à obesidade podem não ter uma causa genética. Há pouca informação relacionando a perda de peso à prevenção do aborto.

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Borilli, Nicoly Abido, and Iáskara Vieira De Oliveira. "ANÁLISE CROMOSSÔMICA PRÉ-IMPLANTACIONAL NÃO INVASIVA DE EMBRIÕES." In I Congresso On-line Nacional de Histologia e Embriologia Humana. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2712.

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Introdução: Em torno de 2016 surgiu a biópsia não invasiva de embriões que consiste, basicamente, na análise do DNA livre no meio de cultivo embrionário para a realização do NICS (do inglês: Non Invasive Chromosome Screening; do português: triagem cromossômica não invasiva), fazendo com que a retirada das células embrionárias não se torne mais necessária. Objetivo: descrever o que é e quais as vantagens da analise não invasiva de embriões e comparar e verificar as taxas de concordância entre as técnicas de biópsia tradicional e NICS por meio de uma revisão de literatura que reuniu e sintetizou resultados de trabalhos científicos sobre análise genética pré-implantacional não invasiva de embriões. Material e métodos: A busca dos artigos foi realizada em 2 bases de dados científicas e foram registrados os dados referentes ao objetivo, tipo de estudo, método de inclusão e exclusão de artigos, resultados e conclusões. Resultados: Em uma literatura analisada foram encontradas diferenças de 1,46% entre as técnicas, quando comparados os resultados de euploidia e aneuploidia. Outro estudo identificou uma diferença de 2,13% para embriões aneuploides e 10,64% para euploides, 8,51% não puderam ser analisados pela técnica de PGT-A (Teste Genético Pré-implantacional para a realização da análise genética de aneuploidias - técnica tradicional). Um dos artigos analisados demonstrou uma diferença significativa de 46,42% para embriões aneuploides e 37,5% para embriões euploides. Um dos estudos informou sucesso de 99,10% e 94,80% de amplificação nas técnicas de biópsia de trofectoderma e não invasiva, respectivamente. Relatou que amostras de meio coletadas nos dias 6/7 tem uma menor chance de apresentarem resultados falso positivos em comparação com amostras de dia 5 (8,6% - D6/7 e 29,6% - D5). Conclusão: Apesar das vantagens, a biópsia não invasiva tem uma grande desvantagem: baixa quantidade de material genético encontrado nos meios de cultura. É importante ressaltar que, mesmo aprimorando a técnica não invasiva, o PGT segue sendo muito importante. Contudo, a biópsia não invasiva deve seguir sendo estudada, pois pacientes que não teriam as qualificações necessárias para a realização de uma biópsia tradicional poderão ter mais garantia e segurança de que seu embrião será geneticamente normal em caso de implantação.

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Eggensberger, T., M. Ponnath, M. Hatzipanagiotou, D. Huber, EC Inwald, O. Ortmann, and U. Germer. "Pränatale Diagnose struktureller Fehlbildungen bei euploiden Feten in Abhängigkeit vom ETS." In Interdisziplinärer Kongress | Ultraschall 2018 – 42. Dreiländertreffen SGUM | DEGUM | ÖGUM. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1670444.

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Simonetti, Giorgia, Antonella Padella, Marco Manfrini, ĺtalo Faria do Valle, Cristina Papayannidis, Carmen Baldazzi, Maria Chiara Fontana, et al. "Abstract 90: A cell cycle-related genomic and transcriptomic signature distinguish aneuploid and euploid acute myeloid leukemia." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-90.

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Tekesin, I., and O. Graupner. "Evaluierung des unteren Gesichtswinkels (IFA), Maxilla-Mandibula-Nasen-Winkels (MMN) und der Prefrontal Space Ratio (PFSR) bei euploiden Feten im Vergleich zu Feten mit Trisomie 21 im ersten Trimenon." In Interdisziplinärer Kongress | Ultraschall 2018 – 42. Dreiländertreffen SGUM | DEGUM | ÖGUM. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1670403.

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