Academic literature on the topic 'Evolution (Biology) – Research'

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Journal articles on the topic "Evolution (Biology) – Research"

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Dolan, Erin L. "Biology Education Research—A Cultural (R)evolution." CBE—Life Sciences Education 11, no. 4 (December 2012): 333–34. http://dx.doi.org/10.1187/cbe.12-09-0166.

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Haila, Y., and C. R. Margules. "Survey research in conservation biology." Ecography 19, no. 3 (September 1996): 323–31. http://dx.doi.org/10.1111/j.1600-0587.1996.tb00243.x.

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Cotner, Sehoya, and Sadie Hebert. "Bean Beetles Make Biology Research Sexy." American Biology Teacher 78, no. 3 (March 1, 2016): 233–40. http://dx.doi.org/10.1525/abt.2016.78.3.233.

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We describe a multiweek laboratory exercise that engages students in class-based research related to sexual reproduction, selection, orientation, and operational sex ratios. Specifically, students discuss contemporary research on sex in the bean beetle, Callosobruchus maculatus, and then develop and test hypotheses related to bean beetle sex. Working with bean beetles is inexpensive and logistically manageable, allowing instructors to scale up to large-enrollment courses. In addition, live organisms engage students in meaningful dialogue related to evolution, sex, and the process of science itself.
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Newby, Jill. "Evolution of a library research methods course for biology students." Research Strategies 17, no. 1 (March 2000): 57–62. http://dx.doi.org/10.1016/s0734-3310(00)00024-0.

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Liu, Chao, Lian Fen Liu, Fu Guo Li, Nai Hua Jiang, Wen Juan Guo, and Ji Kui Li. "Analysis of the Evolution and Structure of Systems Biology." Advanced Materials Research 488-489 (March 2012): 1006–10. http://dx.doi.org/10.4028/www.scientific.net/amr.488-489.1006.

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Systems biology is a term used to describe a number of trends in bioscience research, and a movement which draws on those trends. Systems biology aims to understand the biology from the system level. The fundamental challenge of systems biology is to establish a complete, detailed description of the link between biological molecules and to study molecular interactions and the close association between the physiological responses. Systems biology methods in the system under the guidance will enable us to break the shackles of the old research model to study life from the grasp of the whole phenomenon. We must effectively grasp and follow the systems biology approach to guide our biological research practice.
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Harley, Calvin B. "Biology and Evolution of Aging: Implications for Basic Gerontological Health Research." Canadian Journal on Aging / La Revue canadienne du vieillissement 7, no. 2 (1988): 100–113. http://dx.doi.org/10.1017/s0714980800007340.

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ABSTRACTThe maximum lifespan of different animal species is genetically determined. Many biochemical and physiological systems which influence longevity have apparently evolved to regulate growth and development in a way which maximizes fitness given the ecological niche and constraints on the species. The diversity of individual genetic effects on aging makes it unlikely that either extrinsic factors such as nutrition and medicine or genetic intervention will have dramatic effects on the maximum lifespan of a species, in spite of significant qualitative effects on individuals. However, understanding the fundamental genetic determinants of senescence may be of particular importance to the treatment and or prevention of age associated problems involving tissue degeneration and/or cancer. Considerable investment in basic biological research on both aging and developmental processes is needed before this understanding can be achieved.
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Trent, Jonathan C. "Rapid evolution of the biology and treatment of sarcoma." Current Opinion in Oncology 20, no. 4 (July 2008): 393–94. http://dx.doi.org/10.1097/cco.0b013e328303ba31.

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Bi, Wang, and Zhang. "Omics Analysis for Dinoflagellates Biology Research." Microorganisms 7, no. 9 (August 23, 2019): 288. http://dx.doi.org/10.3390/microorganisms7090288.

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Dinoflagellates are important primary producers for marine ecosystems and are also responsible for certain essential components in human foods. However, they are also notorious for their ability to form harmful algal blooms, and cause shellfish poisoning. Although much work has been devoted to dinoflagellates in recent decades, our understanding of them at a molecular level is still limited owing to some of their challenging biological properties, such as large genome size, permanently condensed liquid-crystalline chromosomes, and the 10-fold lower ratio of protein to DNA than other eukaryotic species. In recent years, omics technologies, such as genomics, transcriptomics, proteomics, and metabolomics, have been applied to the study of marine dinoflagellates and have uncovered many new physiological and metabolic characteristics of dinoflagellates. In this article, we review recent application of omics technologies in revealing some of the unusual features of dinoflagellate genomes and molecular mechanisms relevant to their biology, including the mechanism of harmful algal bloom formations, toxin biosynthesis, symbiosis, lipid biosynthesis, as well as species identification and evolution. We also discuss the challenges and provide prospective further study directions and applications of dinoflagellates.
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Banzhaf, Wolfgang, Guillaume Beslon, Steffen Christensen, James A. Foster, François Képès, Virginie Lefort, Julian F. Miller, Miroslav Radman, and Jeremy J. Ramsden. "From artificial evolution to computational evolution: a research agenda." Nature Reviews Genetics 7, no. 9 (August 8, 2006): 729–35. http://dx.doi.org/10.1038/nrg1921.

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Fenchel, Tom, and Franz Uiblein. "Marine Biology Research – the third year." Marine Biology Research 3, no. 1 (March 2007): 1–2. http://dx.doi.org/10.1080/17451000701225896.

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Dissertations / Theses on the topic "Evolution (Biology) – Research"

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Losseau-Hoebeke, Michèle. "The biology of four haplochromine species of Lake Kivu (Zaïre) with evolutionary implications." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1005082.

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Four species were selected within the littoral of Tshegera Island, and include H. astatodon, H. olivaceus, H. crebridens and H. paucidens. These species, identified on basis of the SMRS, express their individuality most strongly with respect to dentition, breeding colours, normal habitat and preferred breeding territory. All four species are maternal mouthbrooders. This reproductive strategy is characterized by complete division of labour and polygamy. Breeding males compete for optimal territories and ready to spawn females. They are characterized by fast growth, large size and overall low condition factor. Females invest in few but large yolked ova and go through a fasting period while incubating the eggs. Females are generally characterized by slower growth, smaller size and higher condition factor when compared to males. In females the energy turnover during gonadal development and subsequent mouthbrooding is high, but the energy expenditure low. Mean fecundity varies between 25 and 36 eggs per brood and mean egg size between 2.6 and 2.7 rnrn. The right ovary, although small, is functional. Breeding of variable intensity goes on throughout the year. The main dry season corresponds to synchronized breeding. During the other months of the year species breed asynchronously. Both types of breeding are related to food availability for adults and offspring. The major breeding peak which starts in July coincides to improved body condition in both sexes. In similarity with the East African flocks, the Lake Kivu haplochromines display subdivision within the major trophic groups and invasion of the major lacustrine habitats. They are nevertheless morphologically and ecologically generalized. They tend to be plesiomorphic with low diversification within each trophic group, have a lake wide distribution (eurytopic) and incline to be altricial within their specialized reproductive guild. The evolutionary status of the Lake Kivu haplochromines may be explained by survival of members of an ancestral fauna in an isolated bay during the Recent volcanic events which destroyed life in the Main Basin. The Lake Kivu flock, therefore, is a relict and is believed not to have evolved within the confines of the present-day lake.
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Struck, Travis Jared, and Travis Jared Struck. "Research Effort and Evolutionary Properties of Genes." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/621183.

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Recent research effort (measured in number of publications) on genes is biased towards genes that have been studied heavily in the past. Some factors for why this occurs is that many of these historically studied genes are important for survival or there are more tools available that make genetic studies of them much more accessible. Studies of research effort on \textit{Saccharomyces cerevisiae} genes characterized with genetic or protein interactions found that there is an aversion to studying lesser-known genes in networks. As well, in a study of three human protein families, many of the genes that have recently been discovered to have association with complex disease, through methods such as genome wide association studies (GWAS), are understudied in the present compared to the small number of historically heavily studied genes. In this study we explore possible causes of and diversion from this preferential bias with gene conservation and human genes being disease-associated. We find there is some evidence of conservation driving biases in research effort for essential genes in \textit{Saccharomyces cerevisiae}, but inconclusive evidence in other organisms. We look for effects of disease association through Mendelian and complex diseases in a historical, pre-GWAS, and contemporary, post-GWAS, context. Within both contexts we find that Mendelian disease genes may drive preferential study bias. For contemporary research effort we utilize a model of publication rates and find that there are individual GWAS genes that tend to be investigated more than predicted compared to non-GWAS genes. It appears that the proportion of GWAS genes that had highly unexpected increases in publication rate compared to model predictions rose fairly quickly but has been declining. Our analysis suggests that GWAS has had a small impact on what genes some scientists study despite preferential study biases. However GWAS gene-disease association's impact on research effort appears to be declining, possibly due to scientists not being as interested in GWAS results as time goes on.
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Paul, Reeba. "Molecular Evolution of CTL Epitopes in HIV-1: Understanding Geographic Variations." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1471438387.

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Saha, Mandal Arnab. "Computational Analysis of the Evolution of Non-Coding Genomic Sequences." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1372349811.

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Loh, Yong-Hwee Eddie. "Genetic variation in fast-evolving East African cichlid fishes: an evolutionary perspective." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41148.

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Cichlid fishes from the East African Rift lakes Victoria, Tanganyika and Malawi represent a preeminent example of replicated and rapid evolutionary radiation. In this single natural system, numerous morphological (eg. jaw and tooth shape, color patterns, visual sensitivity), behavioral (eg. bower-building) and physiological (eg. development, neural patterning) phenotypes have emerged, much akin to a mutagenic screen. This dissertation encompasses three studies that seek to decipher the underpinnings of such rapid evolutionary diversification, investigated via the genetic variation in East African cichlids. We generated a valuable cichlid genomic resource of five low-coverage Lake Malawi cichlid genomes, from which the general properties of the genome were characterized. Nucleotide diversity of Malawi cichlids was low at 0.26%, and a sample genotyping study found that biallelic polymorphisms segregate widely throughout the Malawi species flock, making each species a mosaic of ancestrally polymorphic genomes. A second genotyping study expanded our evolutionary analysis to cover the entire East African cichlid radiation, where we found that more than 40% of single nucleotide polymorphisms (SNPs) were ancestral polymorphisms shared across multiple lakes. Bayesian analysis of genetic structure in the data supported the hypothesis that riverine species had contributed significantly to the genomes of Malawi cichlids and that Lake Malawi cichlids are not monophyletic. Both genotyping studies also identified interesting loci involved in important sensory as well as developmental pathways that were well differentiated between species and lineages. We also investigated cichlid genetic variation in relation to the evolution of microRNA regulation, and found that divergent selection on miRNA target sites may have led to differential gene expression, which contributed to the diversification of cichlid species. Overall, the patterns of cichlid genetic variation seem to be dominated by the phenomena of extensive sharing of ancestral polymorphisms. We thus believe that standing genetic variation in the form of ancestrally inherited polymorphisms, as opposed to variations arising from new mutations, provides much of the genetic diversity on which selection acts, allowing for the rapid and repeated adaptive radiation of East African cichlids.
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Doherty, Alison H. "The Skeletal Biology of Hibernating Woodchucks (Marmota monax)." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1355252380.

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Sylvester, Jonathan Blaylock. "Brain diversity develops early: a study on the role of patterning on vertebrate brain evolution." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42744.

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The brain has been one of the central foci in studies of vertebrate evolution. Work in East African cichlids and other emerging fish models like the Mexican cavefish (Astyanax mexicanus) offer new insight on the role of patterning on brain evolution. These fish can be grouped into two major categories according to habitat; for cichlids it is rock-dwelling (known locally as mbuna) and sand-dwelling (non-mbuna) lineage. The brain development of mbuna versus non-mbuna is defined by changes in gene deployment working along the dorsal/ventral (DV) and anterior/posterior (AP) neuraxes, respectively. Comparison of disparate fish ecotypes offer a new perspective of the role of patterning on brain evolution; through the slight and early modification of signal pathways working across 3-D axes, and a subsequent magnifying effect across ontogeny, evolution can generate widespread changes in the brain. To illustrate this patterning model of brain evolution, two comparative studies were done between mbuna and non-mbuna, examining the action of gene pathways that work to pattern the cichlid forebrain. The first study found that non-mbuna cichlids have a more rapid AP expansion of a gene pathway (Wingless) into the presumptive midbrain and diencephalon versus mbuna. These forebrain structures are involved in sight processing and could be of ecological benefit to vision-focused non-mbuna. The second study described a difference within the developing telencephalon. The embryonic telencephalon is split into the pallium, which processes visual signals, and the subpallium, which develops into the olfactory bulbs. Mbuna possess a larger subpallium relative to non-mbuna, which have a larger pallium. This was correlated to a more rapid expansion of another gene pathway (Hedgehog) along the DV axis. The difference in size of the pallial vs. subpallialial comparments between cichlids can be correlated to expanded olfaction in mbuna and vision in non-mbuna adult brains. Overall, East African cichlids are an excellent system to investigate the role of patterning on brain evolution because they allow for the comparison of the earliest patterning events in brain ontogeny between distinct ecotypes. These fish systems link study in brain development to the brain morphology comparisons employed in classic studies of brain evolution.
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Weber, Zachary Thomas. "Applications of ctDNA Genomic Profiling to Metastatic Triple Negative Breast Cancer." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586787923790178.

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Nam, Bora. "EVOLUTION OF EQUINE ARTERITIS VIRUS DURING PERSISTENT INFECTION IN THE REPRODUCTIVE TRACT OF THE STALLION AND THE MALE DONKEY." UKnowledge, 2017. https://uknowledge.uky.edu/gluck_etds/34.

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Equine arteritis virus (EAV) establishes persistent infection in the stallion reproductive tract, and the carrier stallion continues to shed virus in semen for weeks to years or lifelong. The objective of this study was to elucidate the intra-host evolution of EAV during persistent infection in stallions. Seven EAV seronegative stallions were experimentally infected with EAV KY84 strain and followed for 726 days post-infection, and sequential clinical samples including semen were collected for virus isolation and next-generation sequencing (NGS). In addition, archived sequential semen samples from two stallions that were naturally infected with EAV KY84 for a long-period (up to 10 years) were also sequenced by NGS. The data demonstrated genetic bottleneck event and selection during acute infection followed by intra-host quasispecies diversification during persistent infection in the stallion reproductive tract. Also, the full-length genome of a novel EAV donkey strain from Chile and a noncytopathic bovine viral diarrhea virus-1 (ncpBVDV-1) strain contaminating rabbit kidney-13 cells were also sequenced by NGS. The EAV donkey strain was genetically distinct but antigenically cross-reacted with EAV antisera, and it was phylogenetically closely related to the South African donkey strain of EAV. Genetic and phylogenetic analyses demonstrated that ncpBVDV-1 belongs to BVDV-1b group.
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Anderson, Michael Gareth. "Evolutionary interactions of brood parasites and their hosts : recognition, communication and breeding biology : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Ecology at Massey University, Auckland, New Zealand." Massey University, 2009. http://hdl.handle.net/10179/1167.

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Obligate brood parasites lay their eggs in nests of other species, relying on these host parents to care for their offspring. This phenomenon has been a curiosity amongst researchers since its first description and has become a model study system for testing such ideas as coevolution and species recognition. This thesis examines a few of the many questions that arise from this breeding system. The New Zealand Grey Warbler (Gerygone igata) and its brood parasite, the Shining Cuckoo (Chrysococcyx lucidus) are used as the main study species, although research on the eviction behaviour of Common Cuckoos (Cuculus canorus) has also been conducted. First, the current state of knowledge and recent discoveries regarding nestling rejection abilities of hosts is reviewed in chapter one. Second, a comparative study of New Zealand passerine begging calls has been conducted to test for begging call similarity between a brood parasite and its host, as well as developing a new technique for detecting the mode of coevolution that may be occurring in the parasite – host relationship. Parent-offspring communication in Grey Warblers is also examined to test for both parental and nestlings Parents use both alarm calls to warn offspring of potential danger, and also parental feeding calls to elicit a begging response from nestlings. By contrast, nestlings are able to signal both age and short term levels of need to parents through the acoustic structure of the begging call. The evolutionary costs and benefits of egg eviction behaviour in the Common Cuckoo are also tested. An experimental approach showed that egg eviction had a growth cost, but this cost was temporary and restricted to during and immediately after the egg eviction phase. A pattern of compensatory growth was observed after the eviction period, so that during the later nestling stages there was no difference in mass, and no difference in fledging age. Finally, variation in the Grey Warbler breeding biology and Shining Cuckoo parasitism rates are examined through both time and across latitudes. This research has shown a counterintuitive pattern of breeding phenology across latitudes. These patterns have implications for Shining Cuckoos both in terms of timing of available nests and host selection. Keywords: Begging call, breeding phenology, brood parasitism, coevolution, Common Cuckoo, eviction, Grey Warbler, parent-offspring communication, Shining Cuckoo.
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Books on the topic "Evolution (Biology) – Research"

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1962-, Herron Jon C., ed. Evolutionary analysis. 4th ed. Upper Saddle River, NJ: Pearson Prentice Hall, 2007.

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Scott, Freeman. Evolutionary analysis. Upper Saddle River, N.J: Prentice Hall, 1998.

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Scott, Freeman. Evolutionary analysis. 3rd ed. Upper Saddle River, NJ: Pearson Education, 2004.

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In the light of evolution: Essays from the laboratory and the field. Greenwood Village, Colo.: Roberts, 2011.

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Shanks, Niall. Animal models in light of evolution. Boca Raton, Fla: BrownWalker Press, 2009.

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Ray, Greek C., ed. Animal models in light of evolution. Boca Raton, Fla: BrownWalker Press, 2009.

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Shanks, Niall. Animal models in light of evolution. Boca Raton, Fla: BrownWalker Press, 2009.

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Mazur, Suzan. The Altenberg 16: An expose of the evolution industry. Berkeley: North Atlantic Book, 2009.

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The Altenberg 16: An expose of the evolution industry. Berkeley, Calif: North Atlantic Book, 2010.

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C, Johanson Donald, ed. Blueprints: Solving the mystery of evolution. New York, N.Y., U.S.A: Penguin Books, 1990.

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Book chapters on the topic "Evolution (Biology) – Research"

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Serrelli, Emanuele, and Nathalie Gontier. "Macroevolutionary Issues and Approaches in Evolutionary Biology." In Interdisciplinary Evolution Research, 1–25. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-15045-1_1.

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Jaramillo, M. Alejandra, and Robert Marquis. "Future Research in Piper Biology." In Piper: A Model Genus for Studies of Phytochemistry, Ecology, and Evolution, 199–203. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-0-387-30599-8_11.

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Hamilton-Smith, Elery. "Reflections on the evolution of bat research." In The Biology and Conservation of Australasian Bats, 13–19. P.O. Box 20, Mosman NSW 2088, Australia: Royal Zoological Society of New South Wales, 2011. http://dx.doi.org/10.7882/fs.2011.004.

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Ponder, Winston F., David R. Lindberg, and Juliet M. Ponder. "Research on Molluscs – Some Historical, Present, and Future Directions." In Biology and Evolution of the Mollusca, 667–73. Boca Raton : Taylor & Francis, 2019.: CRC Press, 2019. http://dx.doi.org/10.1201/9781351115667-11.

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Layzell, Paul. "A new research tool for intrinsic hardware evolution." In Evolvable Systems: From Biology to Hardware, 47–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/bfb0057606.

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Moreno-Santillán, Diana D., and Jorge Ortega. "Molecular Biology in the Evolution of Bats: A Historical Perspective." In 50 Years of Bat Research, 273–87. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-54727-1_17.

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Hori, H., and Y. Satow. "Dead-end evolution of the Cnidaria as deduced from 5S ribosomal RNA sequences." In Coelenterate Biology: Recent Research on Cnidaria and Ctenophora, 505–8. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3240-4_70.

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Gouret, Philippe, Julien Paganini, Jacques Dainat, Dorra Louati, Elodie Darbo, Pierre Pontarotti, and Anthony Levasseur. "Integration of Evolutionary Biology Concepts for Functional Annotation and Automation of Complex Research in Evolution: The Multi-Agent Software System DAGOBAH." In Evolutionary Biology – Concepts, Biodiversity, Macroevolution and Genome Evolution, 71–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-20763-1_5.

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Clarke, Dave J. "Systematics, Natural History, and Evolution of the Saw-Lipped Rove Beetles (Euaesthetinae): Progress and Prospects for Future Research." In Biology of Rove Beetles (Staphylinidae), 81–114. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70257-5_6.

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Estacio, Randel D. "The Effect of Concept Cartoons as an Instructional Material and Formative Assessment Tool in Teaching Evolution and Diversity on the Achievement of Freshmen College Students." In Biology Education and Research in a Changing Planet, 71–79. Singapore: Springer Singapore, 2015. http://dx.doi.org/10.1007/978-981-287-524-2_8.

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Conference papers on the topic "Evolution (Biology) – Research"

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"A Grammatical View of Language Evolution." In AI Methods for Interdisciplinary Research in Language and Biology. SciTePress - Science and and Technology Publications, 2011. http://dx.doi.org/10.5220/0003309200570066.

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McAllister, T. "The evolution of tissue engineered vascular grafts: from research to clinical practice." In 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010). IEEE, 2010. http://dx.doi.org/10.1109/iembs.2010.5627457.

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Taylor, Stephen. "From Program Music to Sonification: Representation and the Evolution of Music and Language." In The 23rd International Conference on Auditory Display. Arlington, Virginia: The International Community for Auditory Display, 2017. http://dx.doi.org/10.21785/icad2017.060.

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Research into the origins of music and language can shed new light on musical representation, including program music and more recent incarnations such as data sonification. Although sonification and program music have different aims — one scientific explication, the other artistic expression — similar techniques, relying on human and animal biology, cognition, and culture, underlie both. Examples include Western composers such as Beethoven and Berlioz, to more recent figures like Messiaen, Stockhausen and Tom Johnson, as well as music theory, semiotics, biology, and data sonifications by myself and others. The common thread connecting these diverse examples is the use of human musicality, in the bio- musicological sense, for representation. Links between musicality and representation — dimensions like high/low, long/short, near/far, etc., bridging the real and abstract — can prove useful for researchers, sound designers, and composers.
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Watton, Paul N., Marc Homer, Justin Penrose, Harry Thompson, Haoyu Chen, Alisa Selimovic, and Yiannis Ventikos. "Patient-Specific Modelling of Intracranial Aneurysm Evolution." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53223.

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Intracranial aneurysms appear as sac-like outpouchings of the cerebral vasculature wall; inflated by the pressure of the blood that fills them. They are relatively common and affect up to 5% of the adult population. Fortunately, most remain asymptomatic. However, there is a small but inherent risk of rupture: 0.1% to 1% of detected aneurysms rupture every year. If rupture does occur there is a 30% to 50% chance of fatality. Consequently, if an aneurysm is detected, clinical intervention may be deemed appropriate. Therapy is currently aimed at pre-rupture detection and preventative treatment. However, interventional procedures are not without risk to the patient. The improvement and optimization of interventional techniques is an important concern for patient welfare and is necessary for rationalisation of healthcare priorities. Hence there is a need to develop methodologies to assist in identifying those ICAs most at risk of rupture. We focus on the mathematical modelling and computational simulation of ICA evolution. Models must take into consideration: (i) the biomechanics of the arterial wall; (ii) the biology of the arterial wall and (iii) the complex interplay between (i) and (ii), i.e. the mechanobiology of the arterial wall. The ultimate ambition of such models is to aid clinical diagnosis on a patient-specific basis. However, due to the significant biological complexity coupled with limited histological information such models are still in their relative infancy. Current research focuses on simulating the evolution of an ICA with an aim to yield insight into the growth and remodelling (G&R) processes that give rise to inception, enlargement, stabilisation and rupture. We present a novel Fluid-Structure-Growth computational framework for modelling aneurysm evolution.
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Sadler, J. Evan. "THE MOLECULAR BIOLOGY OF VON WILLEBRAND FACTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643930.

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Human von Willebrand factor (vWF) is a plasma glycoprotein that is synthesized by endothelial cells and megakaryocytes, and perhaps by syncytiotrophoblast of placenta. The biosynthesis of vWF is very complex, involving proteolytic processing, glycosyla-tion, disulfide bond formation, and sulfation. Mature vWF consists of a single subunit of ∼ 250,000 daltons that is assembled into multimer ranging from dimers to species of over 10 million daltons. vWF performs its essential hemostatic function through several binding interactions, forming a bridge between specific receptors on the platelet surface and components of damaged vascular subendothelial connective tissue. Inherited deficiency of vWF, or von Willebrand disease (vWD), is the most common genetically transmitted bleeding disorder worldwide. The last two years has been a time of very rapid progress in understanding the molecular biology of vWF. Four research groups have independently isolated and sequenced the 9 kilobase full-length vWF cDNA. The predicted protein sequence has provided a foundation for understanding the biosynthetic processing of vWF, and has clarified the relationship between vWF and a 75-100 kilodalton plasma protein of unknown function, von Willebrand antigen II (vWAgll)/ vWAgll is co-distributed with vWF in endothelial cells and platelets, and is deficient in patients with vWD. The cDNA sequence of vWF shows that vWAgll is a rather large pro-peptide for vWF, explaining the biochemical and genetic association between the two proteins. vWF has a complex evolutionary history marked by many separate gene segment duplications. The primary structure of the protein contains four distinct types of repeated domains present in two to four copies each. Repeated domains account for over 90 percent of the protein sequence. This sequence provides a framework for ordering the functional domains that have been defined by protein chemistry methods. A tryptic peptide from the amino-terminus of vWF that overlaps domain D3 binds to factor VIII and also appears to bind to heparin. Peptides that include domain A1 bind to collagens, to heparin, and to platelet glycoprotein Ib. A second collagen binding site appears to lie within domain A3. The vWF cDNA has been expressed in heterologous cells to produce small amounts of functionally and structurally normal vWF, indicating that endothelial cells are not unique in their ability to process and assemble vWF multimers. Site-directed mutagenesis has been used to show that deletion of the propeptide of vWF prevents the formation of multimers. Cloned cDNA probes have been employed to isolate vWF genomic DNA from cosmid and λ-phage libraries, and the size of the vWF gene appears to be ∼ 150 kilobases. The vWF locus has been localized to human chromosome 12p12—pter. Several intragenic RFLPs have been characterized. With them, vWF has been placed on the human genetic linkage map as the most telomeric marker currently available for the short arm of chromosome 12. A second apparently homologous locus has been identified on chromosome 22, but the relationship of this locus to the authentic vWF gene is not yet known. The mechanism of vWD has been studied by Southern blotting of genomic DNA with cDNA probes in a few patients. Three unrelated pedigrees have been shown to have total deletions of the vWF gene as the cause of severe vWD (type III). This form of gene deletion appears to predispose to the development of inhibitory alloantibodies to vWF during therapy with cryoprecipitate. During the next several years recombinant DNA methods will continue to contribute our understanding of the evolution, biosynthesis, and structure-function relationships of vWF, as well as the mechanism of additional variants of vWD at the level of gene structure.
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Cebral, Juan R., and Christopher M. Putman. "Relating Wall Shear Stress, Bleb Formation and Rupture of Cerebral Aneurysms: Image-Based Modeling and Clinical Observations." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192364.

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Cerebral aneurysms are widely believed to form and grow as a result of the interactions of hemodynamics and wall mechano-biology. Researchers have used a variety of tools to study these complex multi-factorial mechanisms including animal, in vitro, and computational models. The goal of these experiments has been to approximate the in vivo environment so that theories about the natural history of brain aneurysms can be developed and tested in realistic systems. Studying the link between hemodynamics and clinical observations of aneurysm progression is necessary to reach an understanding of the relative importance of the different mechanisms involved in these processes [1]. The objective of our research is to investigate the possible relationship between wall shear stress (WSS) — which is known to regulate mechano-biological processes at the arterial wall — produced by different blood flow patterns and the evolution and rupture of cerebral aneurysms.
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Cebral, Juan R., Daniel Sforza, Satoshi Tateshima, Fernando Vinuela, and Christopher Putman. "Longitudinal Image Based Study of Cerebral Aneurysms: Growth, Contacts and Hemodynamics During Aneurysmal Progression." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53382.

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Improving current procedures for the evaluation and treatment of cerebral aneurysms requires a better understanding of the underlying mechanisms governing their formation, progression and rupture. It is generally accepted that these mechanisms are multi-factorial, involving: hemodynamics, wall biomechanics and mechano-biology, and contacts with peri-aneurysmal structures [1]. However, little is known about the relative importance and interactions of these factors. The broad objective of our research is to investigate the mechanisms of aneurysm progression by studying cerebral aneurysms that are followed longitudinally in time with non-invasive 3D imaging. In this context, the goal of this paper is to highlight the importance of considering possible contacts between the aneurysm and peri-aneurysmal structures and studying their effects on the aneurysm evolution. For this purpose, we present a computational analysis of a growing aneurysm in contact with bones at the base of the skull.
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Sheidaei, A., S. C. Hunley, L. G. Raguin, and S. Baek. "Simulation of Aneurysm Growth With Stepwise Updating of Hemodynamic Loads Using an MRI-Based Geometric Model." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-205499.

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Computer simulations of vascular tissue adaptation under various physiological and pathological conditions have emerged as a new area of research and aided researchers in their understanding of stress-mediated growth and remodeling (G&R) in these structures. With advances in computational biomechanics and biomedical imaging techniques, combinations of these advanced methods will provide promising tools for medical diagnosis and surgical planning in the future (e.g., [1]). Recently Figueroa et al. [2] presented a new computational framework that brings advances in computational biosolid and biofluid mechanics together in order to exploit new information on the biology of vascular growth and remodeling (G&R). Although the framework presented in their paper was generalized for simplicity, they did illustrate the effectiveness of this framework by applying it to a fusiform aneurysm growth with idealized geometry. In the present work, we employ this framework and test it on an anatomically realistic model of abdominal aortic aneurysm (AAA) growth. Similarly to Figueroa et al., when the stress-mediated kinetics only depends on intramural stress, the shape of the aneurysm and the expansion rate are similar to the results from the computation without using an iterative loop. However, we expect that when the stress-mediated kinetics depends on either shear or other hemodynamic components, the evolution of an AAA can change significantly.
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Notonegoro, Hamdan Akbar, Budhy Kurniawan, Jan Setiawan, and Azwar Manaf. "Magnetic hysterysis evolution of Ni-Al alloy with Fe and Mn substitution by vacuum arc melting to produce the room temperature magnetocaloric effect material." In THE 2016 CONFERENCE ON FUNDAMENTAL AND APPLIED SCIENCE FOR ADVANCED TECHNOLOGY (CONFAST 2016): Proceeding of ConFAST 2016 Conference Series: International Conference on Physics and Applied Physics Research (ICPR 2016), International Conference on Industrial Biology (ICIBio 2016), and International Conference on Information System and Applied Mathematics (ICIAMath 2016). Author(s), 2016. http://dx.doi.org/10.1063/1.4953944.

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Su, Biao, Karl-Johan Reite, Martin Føre, Karl Gunnar Aarsæther, Morten Omholt Alver, Per Christian Endresen, David Kristiansen, Joakim Haugen, Walter Caharija, and Andrei Tsarau. "A Multipurpose Framework for Modelling and Simulation of Marine Aquaculture Systems." In ASME 2019 38th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/omae2019-95414.

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Abstract Research within marine aquaculture has either focused on technology (e.g. farming structures, autonomous systems, harvesting and transport technologies) or biology (e.g. biomass control, feeding process, fish behavior and welfare). Here, we present a computational framework allowing the integrated analysis of these two aspects in a flexible and evolutive way. This framework is called FhSim which was originally developed for the modelling and simulation of fisheries operations and aquaculture structures, but its application domain has been continuously extended through different research projects. In this paper, we present the basic design principles and functionality of the FhSim framework with the focus on modelling and simulation of marine aquaculture systems. The basic theories and methods used for the modelling of open net cages, closed cages, fish behavior, feeding processes, and ROV operations in net cages are introduced, respectively. It is also shown how the technological and biological aspects of fish farming can be considered in a specialized or integrated analysis. Furthermore, approaches for combining numerical models with monitoring sensor data, techniques for real-time simulation of fish farming operations and the coupling of FhSim with other simulation programs are discussed.
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