To see the other types of publications on this topic, follow the link: Ewing's criteria.

Journal articles on the topic 'Ewing's criteria'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Ewing's criteria.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Dickman, Paul S., and Timothy J. Triche. "Extraosseous Ewing's sarcoma versus primitiverhabdomyosarcoma: Diagnostic criteria and clinical correlation." Human Pathology 17, no. 9 (1986): 881–93. http://dx.doi.org/10.1016/s0046-8177(86)80638-4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Christie, DRH, AM Bilous, and PJA Carr. "Diagnostic difficulties in extraosseous Ewing's sarcoma: A proposal for diagnostic criteria." Australasian Radiology 41, no. 1 (1997): 22–28. http://dx.doi.org/10.1111/j.1440-1673.1997.tb00463.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Yerigeri, Keval. "Abstract B072: Circulating tumor DNA as a prognostic, diagnostic, and clinical assessment tool for evaluation and management of Ewing's sarcoma: a systematic review." Cancer Immunology Research 13, no. 2_Supplement (2025): B072. https://doi.org/10.1158/2326-6074.io2025-b072.

Full text
Abstract:
Abstract Introduction: Circulating tumor DNA (ctDNA) can be analyzed noninvasively to obtain valuable information for genetic profiling, prognostication, and disease progression/ response to treatment. Use of ctDNA is not routine for Ewing’s sarcoma (EWS), but well-known driver mutations (e.g., EWSR1-FLI1, EWS-ERG) makes for straightforward identification by genomic sequencing or PCR techniques. We review the current literature on applications of ctDNA for EWS. Methods: The PubMed database was queried for all articles on Ewing sarcoma and circulating tumor DNA; 81 hits were identified per the
APA, Harvard, Vancouver, ISO, and other styles
4

Saleh, Mahmoud Mohamed, Tamer Moustafa Abdelrahman, Youusef Madney, Ghada Mohamed, Ahmed Mohammed Shokry, and Amr Farouk Moustafa. "Multiparametric MRI with diffusion-weighted imaging in predicting response to chemotherapy in cases of osteosarcoma and Ewing’s sarcoma." British Journal of Radiology 93, no. 1115 (2020): 20200257. http://dx.doi.org/10.1259/bjr.20200257.

Full text
Abstract:
Objective: To evaluate the multiparametric MRI in predicting chemotherapy response in pathologically proven cases of osteosarcoma and Ewing’s sarcoma. Correlation between the tumor size changes and internal breakdown using RECIST 1.1, modified RECIST, quantitative apparent diffusion coefficient (ADC) and tumor volume as well as dynamic contrast-enhanced MRI (DCE-MRI). Methods: The study included 104 patients pathologically proved osteosarcoma (53) and Ewing`s sarcoma (51) underwent MRI examinations; before and after chemotherapy. All patients were assessed using the RECIST 1.1 criteria, m-RECI
APA, Harvard, Vancouver, ISO, and other styles
5

Ishrat, Khan, Lal Kulmi Durga, Khan Haneef, and Hamid Mohd. "CAN and its Risk Factors for Type2 DM." PJSR 10, no. 2 (2017): 23–27. https://doi.org/10.5281/zenodo.8242686.

Full text
Abstract:
Diabetic Neuropathy (DN) is a heterogeneous disorder that encompasses a wide range of abnormalities affecting both proximal and distal peripheral sensory and motor nerves as well as the autonomic nervous system. DN is among the least recognized and understood complications of diabetes despite its significant negative impact on survival and quality of life. To determine the association of various risk factors with CardiovascularAutonomic Neuropathy (CAN) among Type 2 Diabetes Mellitus individuals, a hospital based cross-sectional study was carried out at SRG Hospital associated with Jhalawar Me
APA, Harvard, Vancouver, ISO, and other styles
6

Bhuvaneswari, T., Kumar Sukumaran Suresh, Baskaran Padmasini, and SampathKumar Ashok. "Prolonged QTC Interval as an Indicator of Cardiac Autonomic Neuropathy in Diabetes Mellitus Patients." International Journal of Pharmaceutical and Clinical Research 15, no. 7 (2023): 916–19. https://doi.org/10.5281/zenodo.11669382.

Full text
Abstract:
<strong>Introduction:</strong>&nbsp;Due to its high risk of cardiac arrhythmias and sudden death from silent myocardial ischaemia, CAN is a significant source of morbidity and mortality in diabetes individuals. Numerous studies have shown that the electrocardiogram&rsquo;s corrected QT interval (QTc) prolongation is a specific, quick, and reliable way to identify cardiac autonomic neuropathy. The objective of the current study was to assess the relationship between the QTc interval and diabetic cardiac autonomic neuropathy.&nbsp;<strong>Material and Methods:&nbsp;</strong>Between April 2020 an
APA, Harvard, Vancouver, ISO, and other styles
7

Chua, Victoria S., Sant P. Chawla, Kitty Zheng, Ted Kim, Giuseppe Del Priore, and Semmie Kim. "Phase II study of SM-88 in Ewing's and other sarcomas." Journal of Clinical Oncology 39, no. 15_suppl (2021): e23505-e23505. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e23505.

Full text
Abstract:
e23505 Background: Sarcomas are rare heterogeneous malignancies. Once recurrent, cure is uncommon. SM-88 (racemetyrosine) is an amino acid analogue with no known cross resistance to typical sarcoma regimens. Based on previous anecdotal experience in Ewing’s (EWS) we initiated a Phase 2 trial (HopES) in EWS and other sarcomas (Ss) after &gt;1 prior systemic therapy. We now report preliminary data after having met prespecified continuation criteria. Methods: Open label prospective trial in 2 separate cohorts (EWS and Ss) of oral SM-88 used with MPS conditioning agents (SM-88 920 mg, methoxsalen
APA, Harvard, Vancouver, ISO, and other styles
8

Tsokos, M., and T. J. Triche. "Correlative ultrastructure and immunocytochemistry in small round cell tumors of childhood." Proceedings, annual meeting, Electron Microscopy Society of America 45 (August 1987): 606–9. http://dx.doi.org/10.1017/s0424820100127487.

Full text
Abstract:
Conventional methods of pathologic evaluation of the undifferentiated solid tumors of childhood, often referred to as “small round cell tumors”, have been notoriously unreliable. Prior to the advent of effective therapy, this was of little consequence. Current treatment methods require precise categorization of these tumors, as tumor response shows wide variation, especially when inappropriate chemotherapeutic agents or radiation therapy are employed. The combination of transmission electron microscopy (TEM) and correlative immunocytochemistry (ICC) has proved to be a powerful tool in deriving
APA, Harvard, Vancouver, ISO, and other styles
9

Dileo, P., F. Grosso, M. Casanova, et al. "Trabectedin (T) in metastatic Ewing's family tumors (EFT) patients (pts) progressing after standard chemotherapy." Journal of Clinical Oncology 25, no. 18_suppl (2007): 10040. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.10040.

Full text
Abstract:
10040 Background: T is a formerly marine-derived agent which is active in human cancers, such as ovarian cancer and adult soft tissue sarcomas (STS). Efficacy of T in pts with unresectable/metastatic pretreated advanced STS was demonstrated in phase II settings. Leiomyosarcoma and liposarcoma were shown to be sensitive, with myxoid liposarcoma being exceedingly responsive. Data are lacking on “small round blue cell” sarcomas, including EFT. In 2000 a phase II study was launched by SENDO in a sarcoma population including EFT. At Istituto Nazionale Tumori, Milano, Italy, some EFT pts were treate
APA, Harvard, Vancouver, ISO, and other styles
10

Hasan, Md Imrul, A. F. M. Shakilur Rahman, Soroar Jahan Towhid, Al Hasan Md Bayzid, Shyamal Kumar, and Ismat Ara Haider. "Clinicopathological Study of Sarcoma Involving the Oral and Maxillofacial Region." Bangladesh Medical Research Council Bulletin 50, no. 2 (2024): 81–88. https://doi.org/10.3329/bmrcb.v50i2.74480.

Full text
Abstract:
Background: Malignant connective tissue tumors, or sarcomas, are derived from the connective tissue of the body. They fall into two categories: hard tissue sarcomas, such as osteosarcoma, Ewing's sarcoma, and chondrosarcoma, and soft tissue sarcomas, such as leiomyosarcoma and rhabdomyosarcoma. Clinicopathological research can shed light on the biological activity of oral sarcomas. Objective: The study intends to explore clinical, pathological, and radiological aspects of sarcoma affecting the oral and maxillofacial regions in a tertiary health care center in Dhaka, Bangladesh. Method: It was
APA, Harvard, Vancouver, ISO, and other styles
11

Croci, Alberto Tesconi, Olavo Pires de Camargo, André Mathias Baptista, and Marcelo Tadeu Caiero. "The use of a modular titanium endoprosthesis in skeletal reconstructions after bone tumor resections: method presentation and analysis of 37 cases." Revista do Hospital das Clínicas 55, no. 5 (2000): 169–76. http://dx.doi.org/10.1590/s0041-87812000000500003.

Full text
Abstract:
We analyzed 37 patients who underwent segmental wide resection of bone tumors and reconstruction with a modular titanium endoprosthesis at the Orthopaedic Oncology Group, between 1992 and 1998. Twelve patients were male and 25 were female, with a mean age of 30 years (9 - 81). The mean follow-up was 14 months (2 - 48). The diagnoses were: osteosarcoma (14 cases), metastatic carcinoma (10), Ewing's sarcoma (4), giant cell tumor (4), malignant fibrous histiocytoma (3), chondrosarcoma (1), and aneurysmal bone cyst (1). Eleven articulated total knee, 8 partial proximal femur with bipolar acetabulu
APA, Harvard, Vancouver, ISO, and other styles
12

Biron, P., P. Reichardt, F. Grosso, et al. "A phase II study of gimatecan as salvage treatment in patients with advanced or metastatic soft tissue sarcoma (STS) relapsing after anthracycline / ifosfamide - based chemotherapy regimens." Journal of Clinical Oncology 25, no. 18_suppl (2007): 10063. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.10063.

Full text
Abstract:
10063 Background: Gimatecan, a new oral camptothecin derivative, showed early clinical activity in patients with STS during the phase I clinical development. Methods: Patients with different histological types of STS, including rhabdomyosarcoma and Ewing's sarcoma of soft parts, and advanced or metastatic disease pretreated with anthracycline and ifosfamide were included. The principal inclusion criteria were: disease not curable with surgery and/or radiation, presence of a measurable progressive lesion(s), pretreatment with 1–3 lines of chemotherapy including adjuvant regimens, ECOG PS 0 to 1
APA, Harvard, Vancouver, ISO, and other styles
13

Akeyson, Edward W., Ian E. McCutcheon, Mark A. Pershouse, Peter A. Steck, and Gregory N. Fuller. "Primitive neuroectodermal tumor of the median nerve Case report with cytogenetic analysis." Journal of Neurosurgery 85, no. 1 (1996): 163–69. http://dx.doi.org/10.3171/jns.1996.85.1.0163.

Full text
Abstract:
✓ The authors describe a malignant peripheral primitive neuroectodermal tumor (PNET) that originated in the median nerve in an elderly adult. After the diagnosis was made by biopsy, the patient underwent radical local resection with interpositional vein grafting of the brachial artery. The tumor had the typical appearance of a primitive neural tumor with small, round cells forming rosettes. It stained positively for both the Ewing's sarcoma/peripheral PNET antigen (HBA-71) and neuron-specific enolase, confirming its neural origin. Ultrastructural examination revealed dense core granules and su
APA, Harvard, Vancouver, ISO, and other styles
14

Anderson, Peter Meade, Maurizio Ghisoli, Minal A. Barve, et al. "A bi-shRNAfurin and GMCSF engineered autologous tumor cell immunotherapy vs. gemcitabine + docetaxel for Ewing sarcoma and with cryoablation in Ewing family tumors." Journal of Clinical Oncology 35, no. 15_suppl (2017): TPS11079. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.tps11079.

Full text
Abstract:
TPS11079 Background: Vigil, an immuno-stimulatory autologous cellular therapy, uses patient tumor cells transfected with a plasmid encoding genes for GM-CSF and furin (to down regulate TGFβ 1&amp;2). A Phase I study in relapsed Ewing’s sarcoma. (N = 16) had one 9 month partial response and a two-year survival rate of 44% [1]. Rapid, durable systemic immune activation was seen in the majority of patients using an IFNƔ ELISPOT assay [2]. We seek to extend these early findings in a randomized Phase 2 study (NCT02511132). Methods: Following surgery (for Vigil manufacture), patients are randomized
APA, Harvard, Vancouver, ISO, and other styles
15

Newton, W. A., E. H. Soule, A. B. Hamoudi, et al. "Histopathology of childhood sarcomas, Intergroup Rhabdomyosarcoma Studies I and II: clinicopathologic correlation." Journal of Clinical Oncology 6, no. 1 (1988): 67–75. http://dx.doi.org/10.1200/jco.1988.6.1.67.

Full text
Abstract:
Histopathologic material from 1,782 patients registered in the Intergroup Rhabdomyosarcoma Study Committee (IRS)-I and -II were reviewed by the IRS Pathology Committee in order to provide a uniform approach to classification and correlate patient survival with tumor type. Categories considered eligible were the four types of rhabdomyosarcoma (RMS) (criteria of Horn and Enterline), extraosseous Ewing's tumor (EOE), and a group of somewhat variable undifferentiated sarcomas designated small round cell sarcoma, type indeterminate (STI). Tumors that were clearly sarcomas but were unclassifiable al
APA, Harvard, Vancouver, ISO, and other styles
16

Ohana, Nissim, Daniel Benharroch, Dimitri Sheinis, and Abraham Cohen. "Traumatic glioblastoma: commentary and suggested mechanism." Journal of International Medical Research 46, no. 6 (2018): 2170–76. http://dx.doi.org/10.1177/0300060518771265.

Full text
Abstract:
The role of head trauma in the development of glioblastoma is highly controversial and has been minimized since first put forward. This is not unexpected because skull injuries are overwhelmingly more common than glioblastoma. This paper presents a commentary based on the contributions of James Ewing, who established a major set of criteria for the recognition of an official relationship between trauma and cancer. Ewing’s criteria were very stringent. The scholars who succeeded Ewing have facilitated the characterization of traumatic brain injuries since the introduction of computed tomography
APA, Harvard, Vancouver, ISO, and other styles
17

Sherbiny, Magdy, Nehal Kamal, and Ahmed Ghoneimy. "Use of Vascularized Fibular Free Flap in the Reconstruction of the Femur in Pediatric and Adolescent Bone Sarcomas: Complications and Functional Outcome." Journal of Reconstructive Microsurgery 35, no. 02 (2018): 156–62. http://dx.doi.org/10.1055/s-0038-1668142.

Full text
Abstract:
Background Most reports on skeletal reconstruction using vascularized fibular free flap include patients with varying age groups and anatomic locations. This study has limited the inclusion criteria to pediatric and adolescent patients diagnosed with bone sarcoma of the femoral shaft. Methods Forty-one patients, diagnosed with a malignant bone tumor of the femoral shaft (21 Ewing's sarcomas and 20 osteosarcomas), were locally treated by joint sparing wide resection and reconstruction using a vascularized fibular free flap. All clinical and radiographic data were reviewed for graft healing and
APA, Harvard, Vancouver, ISO, and other styles
18

du Preez, Johan, Theo le Roux, and Jannes Meijer. "PRIMARY MALIGNANT BONE TUMOURS: EPIDEMIOLOGICAL DATA FROM PRETORIA, SOUTH AFRICA." Orthopaedic Proceedings 105-B, SUPP_15 (2023): 37. http://dx.doi.org/10.1302/1358-992x.2023.15.037.

Full text
Abstract:
Primary malignant bone tumours are a scarce entity with limited population-based data from developing countries. The aim of the study is to investigate the frequency and anatomical distribution of primary malignant bone tumours in a local South African population.This will be an epidemiological retrospective study. Data will be used of patients that were diagnosed with primary malignant bone tumours over a period of nine years spanning from 1 January 2014 to 31 December 2022. This data will be received from private and government laboratories. Data to be considered are type of primary malignan
APA, Harvard, Vancouver, ISO, and other styles
19

Patel, S., A. Pappo, J. Crowley, et al. "A SARC global collaborative phase II trial of R1507, a recombinant human monoclonal antibody to the insulin-like growth factor-1 receptor (IGF1R) in patients with recurrent or refractory sarcomas." Journal of Clinical Oncology 27, no. 15_suppl (2009): 10503. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.10503.

Full text
Abstract:
10503 Background: The IGF1 system has been implicated in sarcoma development and inhibition of IGF1R function has been shown to induce clinical responses in select sarcomas. Methods: Objectives included response rate (RR) and progression-free survival (PFS) to R1507 in patients with recurrent or refractory Ewing's (ES, 2 cohorts- primary refractory vs. others) osteo (OS), synovial (SS), rhabdomyosarcoma (RMS), and other sarcomas. Eligibility included recurrent/refractory measurable disease, age ≥ 12 yrs, life expectancy ≥ 6 weeks, Karnofsky PS ≥ 70, adequate renal, hepatic and bone marrow func
APA, Harvard, Vancouver, ISO, and other styles
20

Roberge, D., M. Hickeson, M. Charest, and R. E. Turcotte. "Utility of total body FDG PET/CT imaging in the initial staging of soft-tissue sarcoma." Journal of Clinical Oncology 27, no. 15_suppl (2009): 10531. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.10531.

Full text
Abstract:
10531 Background: Soft-tissue sarcoma spreads predominantly to the lung. It is currently unclear how often PET scan will detect metastases not already obvious by chest imaging or clinical examination. Methods: Soft-tissue sarcoma cases were identified retrospectively. Ewing's sarcoma, rhabdomyosarcoma and GIST tumors were excluded as were patients imaged for follow-up, response assessment or recurrence. Patients all had had a diagnostic chest CT scan as part of their staging. Directed studies were requested to follow-up on abnormal findings in the clinical history or physical examination. All
APA, Harvard, Vancouver, ISO, and other styles
21

Szmyd, Bartosz, Kamila Wypyszczak, Karolina Miarka-Walczyk, et al. "Rare Candidate Variants for Germline Predisposition to Childhood Lymphomas: Go Beyond Aberrations in DNA Repair Genes." Blood 144, Supplement 1 (2024): 1587. https://doi.org/10.1182/blood-2024-208071.

Full text
Abstract:
Introduction : Approximately 10% of pediatric patients with malignancies carry germline predisposing variants. Regarding pediatric patients who developed lymphoma, the pathogenic abnormalities frequently affect DNA repair genes. Identifying these aberrations may contribute to tailored clinical management, appropriate screening protocols, management of comorbidities, and genetic counseling. Therefore, we aimed to identify genetic predispositions to pediatric lymphoma based on familial history and phenotypical features. Methods: We obtained clinical information about 75 patients diagnosed with l
APA, Harvard, Vancouver, ISO, and other styles
22

Leavey, Patrick J., and Anderson B. Collier. "Ewing sarcoma: prognostic criteria, outcomes and future treatment." Expert Review of Anticancer Therapy 8, no. 4 (2008): 617–24. http://dx.doi.org/10.1586/14737140.8.4.617.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Abu El Afieh, Jude, Marena Gray, Matthew Seah, and Wasim Khan. "Endoprosthetic Reconstruction in Ewing’s Sarcoma Patients: A Systematic Review of Postoperative Complications and Functional Outcomes." Journal of Clinical Medicine 11, no. 15 (2022): 4612. http://dx.doi.org/10.3390/jcm11154612.

Full text
Abstract:
Ewing’s sarcoma (ES) is a rare primary bone cancer managed by radiotherapy, chemotherapy and surgical resection. The existing literature on limb salvage surgery with endoprostheses combines data for ES patients with osteosarcoma. This review aimed to evaluate surgical and functional outcomes of endoprosthetic reconstruction in exclusively Ewing’s patients. We believe that this is the first comprehensive review to evaluate the outcomes of limb salvage surgery with endoprostheses exclusively in Ewing’s sarcoma patients. Clinical data and outcomes were collected from PubMed, Embase, Medline and S
APA, Harvard, Vancouver, ISO, and other styles
24

Consalvo, Sarah, Florian Hinterwimmer, Norbert Harrasser, et al. "C-Reactive Protein Pretreatment-Level Evaluation for Ewing’s Sarcoma Prognosis Assessment—A 15-Year Retrospective Single-Centre Study." Cancers 14, no. 23 (2022): 5898. http://dx.doi.org/10.3390/cancers14235898.

Full text
Abstract:
Background: A pathological/inflamed cellular microenvironment state is an additional risk factor for any cancer type. The importance of a chronic inflammation state in most diffuse types of tumour has already been analysed, except for in Ewing’s sarcoma. It is a highly malignant blue round cell tumour, with 90% of cases occurring in patients aged between 5 and 25 years. Worldwide, 2.9 out of 1,000,000 children per year are affected by this malignancy. The aim of this retrospective study was to analyse the role of C-reactive protein (CRP) as a prognostic factor for Ewing’s sarcomas. Methods: Th
APA, Harvard, Vancouver, ISO, and other styles
25

Morozov, A. K., A. A. Belyaeva, and A. L. Kornachev. "Radiographic Findings for Diagnosis of Primary Tumors 35 and Tumor-Like Diseases of Spine in Children." N.N. Priorov Journal of Traumatology and Orthopedics 3, no. 3 (1996): 35–40. http://dx.doi.org/10.17816/vto101791.

Full text
Abstract:
Retrospective analysis of radiographic semiotics in tumors and tumor-like diseases of spine was performed in 179 children, aged 3-16. Fourteen nosologic forms were revealed, diagnosis was verified morphologically. Eleven patients had malignant tumors (osteogenic sarcoma, Ewings sarcoma, malignant osteoblastoma, chondrosarcoma, malignant neuroblastoma); 67 patients had benign tumors (osteoid-osteoma, osteoblastoma, hemangioma, osteoblastoclastoma, osteochondroma, neurogenic tumors, chondroma); tumor-like diseases were revealed in 101 patients (aneurismal bone cyst, eosinophilic granuloma). The
APA, Harvard, Vancouver, ISO, and other styles
26

Dennington, SL. "The Litoria-Ewingi Complex (Anura, Hylidae) in South-Eastern Australia .9. Variation in Mitochondrial-Dna Across a Narrow Zone of Hybridization Between Litoria-Ewingi and Litoria-Paraewingi." Australian Journal of Zoology 38, no. 1 (1990): 53. http://dx.doi.org/10.1071/zo9900053.

Full text
Abstract:
The mitochondrial DNA (mtDNA) of Litoria ewingi and L. paraewingi, two species of hylid frog occurring in south-eastern Australia, was investigated by restriction enzyme analysis. Clear diagnostic differences between allopatric populations of these two species were shown in several of the fragment patterns. MtDNA haplotypes of individuals from populations along a transect across the southern hybrid zone between L. ewingi and L. paraewingi were identified. Four individuals from these hybrid populations had inherited a unique haplotype of mtDNA. The width of the hybrid zone based on variation in
APA, Harvard, Vancouver, ISO, and other styles
27

Bhati, Pooja, and M. Ejaz Hussain. "Inconsistency amongst the diagnostic criteria based on Ewing’s tests for diagnosing cardiac autonomic neuropathy in diabetes mellitus: an under-rated issue." Clinical Diabetology 9, no. 4 (2020): 269–70. http://dx.doi.org/10.5603/dk.2020.0016.

Full text
APA, Harvard, Vancouver, ISO, and other styles
28

Majeed, Farhan Ahmad, Ghazanfar Ali, Muhammad Nadeem Paraccha, Shahid Hameed, Yasser Saeed Khan, and Zahid Hussain. "Ewing Sarcoma of Chest Wall: Analysis of 19 Patients." Pakistan Armed Forces Medical Journal 72, no. 3 (2022): 971–74. http://dx.doi.org/10.51253/pafmj.v72i3.5738.

Full text
Abstract:
Objective: To share the short and long term outcomes of the patients having Ewing Sarcoma of the chest wall.&#x0D; Study Design: Prospective longitudinal study.&#x0D; Place and Duration of Study: Thoracic Departments of Combined Military Hospital Rawalpindi, Combined Military Hospital Lahore and Combined Military Hospital Multan from Jan 2010 to Jun 2020.&#x0D; Methodology: In total, 19 patients were enrolled. Inclusion criteria were physiologically fit patients for one-lung ventilation with proven true-cut histopathology. Exclusion criteria were poor performance status and non-compliance to c
APA, Harvard, Vancouver, ISO, and other styles
29

Grover, Kritika, Suleyman Noordeen, and Mariam Bihnam. "Comparing two chemotherapeutic regimens VDC/IE (or VAC/IE) v/s VIDE for patients suffering with Ewing sarcoma: A systematic review on survivorship and regime difference across borders." F1000Research 14 (April 4, 2025): 393. https://doi.org/10.12688/f1000research.151734.1.

Full text
Abstract:
Background Ewing sarcoma is the second most common primary bone cancer in adolescents and young adults, with a poor prognosis. It is usually treated with a combination of treatment options, including but not limited to chemotherapy, surgery, and radiation therapy. In this systematic review, we focus on comparing two different chemotherapeutic regimens i.e., VDC/IE (vincristine, doxorubicin, and cyclophosphamide alternating with ifosfamide and etoposide) and VIDE (vincristine, ifosfamide, doxorubicin, and etoposide), for patients with Ewing Sarcoma, with Overall survival as the primary outcome
APA, Harvard, Vancouver, ISO, and other styles
30

Koshkin, Vadim S., Vanessa Bolejack, Lawrence H. Schwartz, et al. "Assessment of Imaging Modalities and Response Metrics in Ewing Sarcoma: Correlation With Survival." Journal of Clinical Oncology 34, no. 30 (2016): 3680–85. http://dx.doi.org/10.1200/jco.2016.68.1858.

Full text
Abstract:
Purpose Despite the rapidly increasing use of [18F]fluorodeoxyglucose (FDG) –positron emission tomography (PET), the comparison of anatomic and functional imaging in the assessment of clinical outcomes has been lacking. In addition, there has not been a rigorous evaluation of how common radiologic criteria or the location of the radiology reader (local v central) compare in the ability to predict benefit. In this study, we aimed to compare the effectiveness of various radiologic response assessments for the prediction of overall survival (OS) within the same data set of patients with sarcoma.
APA, Harvard, Vancouver, ISO, and other styles
31

De Los Santos, Maria Ana Isabel C., Anne-Florence Blandin, Alejandra E. Aguilar, et al. "Abstract 6732: Identifying novel combination therapies for Ewing sarcoma." Cancer Research 83, no. 7_Supplement (2023): 6732. http://dx.doi.org/10.1158/1538-7445.am2023-6732.

Full text
Abstract:
Abstract Ewing sarcoma is the second most common pediatric bone cancer in children and young adults. The standard of care therapy consists of chemotherapy, surgery, and radiation. Despite therapeutic advances, metastatic and relapsed Ewing sarcoma have poor outcomes. This is partially because transcription factors, such as the Ewing sarcoma oncoprotein EWS-FLI1, are difficult targets for the development of small molecules. Novel synergistic combination treatments are needed, and drug repurposing efforts can fast track potential therapies into clinical trials. To identify synergistic anti-Ewing
APA, Harvard, Vancouver, ISO, and other styles
32

Fadul, N. A., F. Strasser, J. L. Palmer, S. Dalal, J. Allo, and E. Bruera. "The association between autonomic dysfunction and survival in advanced cancer: A preliminary report." Journal of Clinical Oncology 27, no. 15_suppl (2009): e20534-e20534. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e20534.

Full text
Abstract:
e20534 Background: Autonomic nervous system dysfunction (AD) is a common syndrome in patients with advanced cancer. It is associated with decreased survival in several patient populations including diabetes mellitus, heart failure and neurological diseases. Based on this available evidence, we hypothesized that autonomic dysfunction is associated with reduced survival in patients with advanced cancer. The objective of this preliminary study was to test the association between AD as measured by the standardized Ewing test and Heart Variability (HRV) measures and survival in patients with advanc
APA, Harvard, Vancouver, ISO, and other styles
33

Chodyla, Michal, Francesco Barbato, Uta Dirksen, et al. "Utility of Integrated PET/MRI for the Primary Diagnostic Work-Up of Patients with Ewing Sarcoma: Preliminary Results." Diagnostics 12, no. 10 (2022): 2278. http://dx.doi.org/10.3390/diagnostics12102278.

Full text
Abstract:
Background: This study was conducted to evaluate the clinical applicability of integrated PET/MRI for staging and monitoring the effectiveness of neoadjuvant chemotherapy in Ewing sarcoma patients. Methods: A total of 11 juvenile patients with confirmed Ewing sarcoma, scheduled for induction polychemotherapy, were prospectively enrolled for a PET/MR examination before, during and after the end of treatment. Two experienced physicians analysed the imaging datasets. They were asked to perform a whole-body staging in all three examinations and to define treatment response according to the RECIST1
APA, Harvard, Vancouver, ISO, and other styles
34

Paul, Jocelyn Sara, S. Sunitha, Amisha Gami, Jahnavi Gandhi, Ashini Shah, and Priti Trivedi. "Rib tumors: A ten-year institutional study." Asian Journal of Oncology 10 (August 5, 2024): 7. http://dx.doi.org/10.25259/asjo-2022-50-(408).

Full text
Abstract:
Objectives The primary aim of this study was to study the demography and frequency distribution of the various rib tumors. The treatment modality offered and patient outcomes were also recorded wherever available. Material and Methods A ten year data was retrieved from the hospital registry from 2011-2021. Inclusion criteria were all patients with any tumors in the rib. Those patients who did not have a histological diagnosis and those having a chest wall mass and secondary involvement of the ribs were excluded. Results Out of 72 cases of rib tumors, 25 were diagnosed as Ewing Sarcoma, 22 Chon
APA, Harvard, Vancouver, ISO, and other styles
35

Koucheki, Robert, Aaron M. Gazendam, Jonathan R. Perera, et al. "Assessment of Risk of Bias in Osteosarcoma and Ewing’s Sarcoma Randomized Controlled Trials: A Systematic Review." Current Oncology 28, no. 5 (2021): 3771–94. http://dx.doi.org/10.3390/curroncol28050322.

Full text
Abstract:
Aim: The aim of this study was to systematically assess the risk of bias in osteosarcoma and Ewing’s sarcoma (ES) randomized controlled trials (RCT) and to examine the relationships between bias and conflict of interest/industry sponsorship. Methods: An OVID-MEDLINE search was performed (1976–2019). Using the Cochrane Collaboration guidelines, two reviewers independently assessed the prevalence of risk of bias in different RCT design domains. The relationship between conflicts of interest and industry funding with the frequency of bias was examined. Results: 73 RCTs met inclusion criteria. Pre
APA, Harvard, Vancouver, ISO, and other styles
36

Hameed, Meera. "Small Round Cell Tumors of Bone." Archives of Pathology & Laboratory Medicine 131, no. 2 (2007): 192–204. http://dx.doi.org/10.5858/2007-131-192-srctob.

Full text
Abstract:
Abstract Context.—Primary small round cell tumors of the bone are a heterogeneous group of malignant neoplasms presenting predominantly in children and adolescents. They include Ewing sarcoma/peripheral neuroectodermal tumor or Ewing family tumors, lymphoma, mesenchymal chondrosarcoma, and small cell osteosarcoma. Even though they share many morphological similarities, their unique biological and genetic characteristics have provided substantial insights into the pathology of these diverse neoplasms. Objective.—To provide an overview of the clinical, radiologic, pathologic, and genetic charact
APA, Harvard, Vancouver, ISO, and other styles
37

Herzog, J., F. von Klot-Heydenfeldt, S. Jabar, et al. "Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity." Sarcoma 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/7461783.

Full text
Abstract:
Background. Preclinical data indicate that trabectedin followed by irinotecan has strong synergistic effects on Ewing sarcoma. This is presumably due to hypersensitization of the tumor cells to the camptothecin as an effect of trabectedin in addition to synergistic suppression of EWS-FLI1 downstream targets. A strong effect was also reported in a human rhabdomyosarcoma xenograft. Procedure. Twelve patients with end-stage refractory translocation-positive sarcomas were treated with trabectedin followed by irinotecan within a compassionate use program. Eight patients had Ewing sarcoma and four p
APA, Harvard, Vancouver, ISO, and other styles
38

Bhati, Pooja, and M. Ejaz Hussain. "Leisure-Time Physical Activity and Glycemic Control Independently Predicts Cardiac Autonomic Neuropathy in Type 2 Diabetes Mellitus." Journal of Physical Activity and Health 18, no. 11 (2021): 1393–403. http://dx.doi.org/10.1123/jpah.2020-0194.

Full text
Abstract:
Background: Though cardiac autonomic neuropathy (CAN) is a common complication of type 2 diabetes mellitus (T2DM); still, there is lack of clarity on pathophysiological correlates for its onset and progression. Therefore, the purpose of this study was to investigate the predictive ability of lifestyle and cardiometabolic risk factors for CAN in T2DM patients. Methods: A total of 105 Indian T2DM patients were recruited in the present study. Cardiometabolic risk factors, such as glycemic control, lipids, resting heart rate, systolic and diastolic blood pressure, and lifestyle risk parameters, su
APA, Harvard, Vancouver, ISO, and other styles
39

Roberge, David, Siavosh Vakilian, Yazan Z. Alabed, Robert E. Turcotte, Carolyn R. Freeman, and Marc Hickeson. "FDG PET/CT in Initial Staging of Adult Soft-Tissue Sarcoma." Sarcoma 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/960194.

Full text
Abstract:
Soft-tissue sarcomas spread predominantly to the lung and it is unclear how often FDG-PET scans will detect metastases not already obvious by chest CT scan or clinical examination. Adult limb and body wall soft-tissue sarcoma cases were identified retrospectively. Ewing’s sarcoma, rhabdomyosarcoma, GIST, desmoid tumors, visceral tumors, bone tumors, and retroperitoneal sarcomas were excluded as were patients imaged for followup, response assessment, or recurrence. All patients had a diagnostic chest CT scan. 109 patients met these criteria, 87% of which had intermediate or high-grade tumors. T
APA, Harvard, Vancouver, ISO, and other styles
40

Songiso, Mpimpa, and Fastone Goma. "A Study of Cardiovascular Autonomic Neuropathy in Adult Patients with Diabetes Mellitus at Levy Mwanawasa University Teaching Hospital." University of Zambia Journal of Agricultural and Biomedical Sciences 6, no. 1 (2022): 18–33. http://dx.doi.org/10.53974/unza.jabs.6.1.776.

Full text
Abstract:
Cardiac autonomic neuropathy (CAN) is the diminished capacity of autonomic regulation of the cardiovascular system occurring in the presence of diabetes mellitus (DM) and in the absence of other aetiologies. Diabetes mellitus is a well- known cause of peripheral neuropathy. However, in comparison to somatic neuropathy, autonomic neuropathy is an under-diagnosed and under-treated chronic complication of diabetes mellitus despite its serious and significant contribution to morbidity and mortality in the diabetes mellitus population. A variety of tests, based on evaluation of the cardiovascular r
APA, Harvard, Vancouver, ISO, and other styles
41

Tang, Lina, Xiaohui Niu, Zhen Wang, et al. "A phase II study of anlotinib in treating patients with relapsed or metastatic primary malignant bone tumor." Journal of Clinical Oncology 38, no. 15_suppl (2020): 11525. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.11525.

Full text
Abstract:
11525 Background: Primary malignant bone tumors are rare forms of cancer and include mainly bone sarcomas, which are categorized into 3 common types based on tissue origin: osteosarcoma, chondrosarcoma and Ewing sarcoma. A phase II trial was designed to explore the anlotinib activity in patients with relapsed or metastatic primary malignant bone tumor. Methods: Eligible pts were received 12mg of anlotinib once daily, 2 weeks on and 1 week off until progression or unacceptable toxicity. Key-eligibility criteria were aged 14-70 years, histologically confirmed diagnosis of osteosarcoma, chondrosa
APA, Harvard, Vancouver, ISO, and other styles
42

Aghakhanyan, Gayane, Tommaso Filidei, Maria Febi, et al. "Advancing Pediatric Sarcomas through Radiomics: A Systematic Review and Prospective Assessment Using Radiomics Quality Score (RQS) and Methodological Radiomics Score (METRICS)." Diagnostics 14, no. 8 (2024): 832. http://dx.doi.org/10.3390/diagnostics14080832.

Full text
Abstract:
Pediatric sarcomas, rare malignancies of mesenchymal origin, pose diagnostic and therapeutic challenges. In this review, we explore the role of radiomics in reshaping our understanding of pediatric sarcomas, emphasizing methodological considerations and applications such as diagnostics and predictive modeling. A systematic review conducted up to November 2023 identified 72 papers on radiomics analysis in pediatric sarcoma from PubMed/MEDLINE, Web of Knowledge, and Scopus. Following inclusion and exclusion criteria, 10 reports were included in this review. The studies, predominantly retrospecti
APA, Harvard, Vancouver, ISO, and other styles
43

Gaspar, Nathalie, Bernadette Brennan, Lee Jeys, et al. "Can postoperative radiotherapy be omitted in localized standard-risk Ewing sarcoma? An observational study of the Euro-EWING Group." Journal of Clinical Oncology 31, no. 15_suppl (2013): 10518. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.10518.

Full text
Abstract:
10518 Background: Uncertainty exists on the most appropriate use of surgery, radiotherapy (RT) or both for treatment of primary Ewing sarcoma (ES). The objective of this study was to assess the impact of postoperative RT on local control in pts with localized ES and good (&lt;10% residual cells) histologic response to chemotherapy (CT). Methods: We analyzed data of all pts included in the EE99-R1 trial (comparing 2 consolidation CT regimens) undergoing surgery after induction CT. Local recurrence (LR) cumulative incidence (CI) was estimated using a competing risk approach. As local therapy was
APA, Harvard, Vancouver, ISO, and other styles
44

Chuk, M. K., F. M. Balis, C. Mackall, et al. "Radiographic tumor response in pediatric patients with newly diagnosed localized (LOC) or metastatic (MET) Ewing’s sarcoma (EWS) following neoadjuvant chemotherapy." Journal of Clinical Oncology 25, no. 18_suppl (2007): 20008. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.20008.

Full text
Abstract:
20008 Background: Standard treatment for EWS includes vincristine, doxorubicin, cyclophosphamide (VDC) alternating with ifosfamide and etoposide (IE). Using this therapy, overall survival is 70% in patients with LOC EWS and 30% in patients with MET EWS. We compared the radiographic response to VDC and IE in patients with LOC or MET EWS. Methods: We conducted a randomized trial comparing pegfilgrastim to filgrastim in patients treated with VDC (cycles 1, 2, 5, 9, 11, 13) and IE (cycles 3, 4, 6–8, 10, 12, 14). Local control with radiation or surgery was initiated after cycle 5. We assessed radio
APA, Harvard, Vancouver, ISO, and other styles
45

Siddique, Furhaj Mueen, Imran Ahmed Moinuddin, Maida Nazir, Muhammad Kashif, Muhammad Mubeen Akhtar, and Asma Jabeen. "Frequency of Cardiac Autonomic Neuropathy and its Various Grades in Type 2 Diabetes Mellitus." Pakistan Journal of Medical and Health Sciences 16, no. 7 (2022): 403–5. http://dx.doi.org/10.53350/pjmhs22167403.

Full text
Abstract:
Introduction: Cardiovascular autonomic neuropathy (CAN) is a common and one of the major complication of diabetes mellitus. It is also the most under diagnosed and least understood diabetic complication4. Objective: To determine the frequency of cardiac autonomic neuropathy and its various grades in type 2 diabetes mellitus. Study Design: Cross Sectional Study. Setting: Medical OPD as well as from diabetic clinic of Services Hospital, Lahore. Methodology: Total 195 patients of either sex or age between 18 to 60 with at least 10 years duration of type 2 Diabetes Mellitus were enrolled. Cardiac
APA, Harvard, Vancouver, ISO, and other styles
46

Mudassar, Muhammad, Farhan Abbas Baloch, Sadia Hameed, Saima Zubair, Shahzada Khalid Sohail, and Muhammad Kamran. "Use of Immunohistochemistry in the differential diagnosis of Small Round Blue cell tumors." Professional Medical Journal 27, no. 08 (2020): 1728–36. http://dx.doi.org/10.29309/tpmj/2020.27.08.4670.

Full text
Abstract:
Objectives: Objective of the study is to differentiate and sub-categorize malignant small round blue cell tumors by using immune-histochemistry. Study Design: Descriptive Observational study. Setting: Meezan Private Lab, Faisalabad, Pakistan. Period: 5 years, from July 2014 to June 2019. Material &amp; Methods: Sample Size: 126 cases of Round blue cells tumors. Sampling Technique: Non probability purposive sampling. Data Collection Procedure: 126 cases which fulfilled the inclusion and exclusion criteria were selected for the study. All these cases were subjected to immunohistochemistry. The I
APA, Harvard, Vancouver, ISO, and other styles
47

Gordon, Erlinda Maria, Victoria S. Chua-Alcala, Katherine Kim, Doris M. Quon, and Sant P. Chawla. "A phase 1b investigation of safety/efficacy of nivolumab and ABI-009 (nab-rapamycin) in advanced undifferentiated pleomorphic sarcoma (UPS), liposarcoma (LPS), chondrosarcoma (CS), osteosarcoma (OS) and Ewing sarcoma." Journal of Clinical Oncology 36, no. 5_suppl (2018): TPS45. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.tps45.

Full text
Abstract:
TPS45 Background: Immune checkpoint inhibitors that promote sustained T cell activation may have synergistic activity with an mTOR inhibitor. Objectives: (1) To investigate the maximum tolerated dose of ABI-009, an mTOR inhibitor, when given sequentially with nivolumab, a PD-1 inhibitor, in advanced UPS, LPS, CS, OS and Ewing sarcoma; (2) To investigate the disease control rate (DCR), progression free survival (PFS), recurrence-free survival (RFS) and overall survival using nivolumab/ABI-009 combination therapy in advanced UPS, LPS, CS, OS and Ewing sarcoma; (3) To correlate disease control ra
APA, Harvard, Vancouver, ISO, and other styles
48

Kurmasheva, Raushan, Yael P. Mosse, Vanessa Del Pozo, et al. "Testing of B7-H3 targeting antibody-drug conjugate (ADC) MGC018 in models of pediatric solid tumors by the Pediatric Preclinical Testing Consortium (PPTC)." Journal of Clinical Oncology 39, no. 15_suppl (2021): 10037. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.10037.

Full text
Abstract:
10037 Background: B7-H3 (encoded by the CD276 gene) is an immunoregulatory molecule that is widely expressed in pediatric embryonal tumors and sarcomas, while expression is limited for normal tissues. Among PPTC models, osteosarcoma models showed highest CD276 transcript levels followed by Wilms tumor, neuroblastoma, rhabdomyosarcoma, and Ewing sarcoma. Protein expression by IHC generally followed expression at the RNA level, with high expression by IHC observed across a range of models. MGC018 is a duocarmycin-based humanized ADC targeting B7-H3 that shows selective cytotoxicity for B7-H3 exp
APA, Harvard, Vancouver, ISO, and other styles
49

Salah, Samer, Yat Hang To, Taleb Ismaeel, et al. "Salvage chemotherapy using irinotecan and temozolamide in pediatric and adult populations with relapsed Ewing sarcoma." Journal of Clinical Oncology 37, no. 15_suppl (2019): e22500-e22500. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e22500.

Full text
Abstract:
e22500 Background: Irinotecan and temozolomide (IT) is a widely used regimen for relapsed Ewing Sarcoma (ES), although studies are largely limited to the paediatric population. We aimed to compare the tolerability and efficacy of IT between paediatric and adult patients. Methods: We retrospectively reviewed paediatric (&lt; 18 years) and adult patients treated with salvage IT chemotherapy at two institutions from March, 2010 to June, 2018. Toxicities were graded according to common terminology criteria of adverse events (CTCAE v. 4.03) and compared using the Chi Square test. Responses were int
APA, Harvard, Vancouver, ISO, and other styles
50

Wagner, Andrew J., Gregory M. Cote, Donald Richards, et al. "Abstract A019: Phase 1, first-in-human, dose-expansion study of oral TP-1287, a cyclin dependent kinase 9 (CDK9) inhibitor, in patients with sarcoma." Clinical Cancer Research 28, no. 18_Supplement (2022): A019. http://dx.doi.org/10.1158/1557-3265.sarcomas22-a019.

Full text
Abstract:
Abstract Background: CDK9 blockade inhibits tumor growth and progression by impairing the transcription of key oncogenes, such as MCL1 and MYC. TP-1287 is an orally delivered phosphate prodrug of the CDK9 inhibitor alvocidib. The anti-tumor activity of alvocidib has previously been shown in vitro in a Ewing sarcoma cell line and in vivo in a mouse Ewing sarcoma xenograft model. TP-1287 is being investigated in a phase 1 dose escalation and dose expansion study in patients with solid tumors (escalation) and sarcoma (expansion) (NCT03604783). The design of the expansion part of the phase 1 study
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!