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Journal articles on the topic 'Ewing T'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2025

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1

Maharjan, Yunash, Adriana C. Tufino, Sreya Dey, Elina Mukherjee, and Kelly M. Bailey. "Abstract B048: Galectin-3 regulation of immunosuppression in Ewing sarcoma." Cancer Research 84, no. 17_Supplement (2024): B048. http://dx.doi.org/10.1158/1538-7445.pediatric24-b048.

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Abstract Objective: Ewing sarcoma is a fusion oncoprotein-driven cancer most commonly diagnosed in adolescents. Utilizing single-cell RNAseq of human Ewing tumors, we have previously demonstrated that Galectin-3, an immunosuppressive lectin family member protein, is expressed in both Ewing tumor cells and in CD8 T cells in the Ewing tumor microenvironment, a finding not noted in CD8 T cells infiltrating osteosarcomas. Galectin-3 serves to modulate tumor immunobiology through multiple mechanisms, including interactions with the immune checkpoint protein LAG3. In addition to Galectin-3, Galectin

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2

Petit, Floriane, Ana Lalanne, Céline Collin, Joshua Waterfall, Olivier Lantz, and Olivier Delattre. "Abstract IA021: Neogenes induced by oncogenic chimeric transcription factors as potential targets for therapy." Cancer Research 84, no. 17_Supplement (2024): IA021. http://dx.doi.org/10.1158/1538-7445.pediatric24-ia021.

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Abstract We recently showed that oncogenic chiemeric transcription factors (OCTF) of various pediatric cancers induce the expression of highly tumor-specific long intergenic non coding RNAs which are not expressed in normal tissues and which we called neogenes. Since recent reports indicate that such LincRNA may not be as non-coding as initially thought we sought for potential peptides encoded by these neogenes. Using the EWSR1::FLI1 chimera of Ewing sarcoma as a paradigm of such chimeras and through Riboseq profiling and whole cell proteomics we indeed show that some of these neogenes encode

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3

Karaman, Ivo. "North American sironids (Opiliones, Cyphophthalmi) and composition of the family Sironidae with a description of two new species." Biologia Serbica 44, no. 2 (2022): 51–77. https://doi.org/10.5281/zenodo.7489147.

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<strong>Summary. </strong>A revised composition of the family Sironidae is given. Two North American genera, namely <em>Holosiro</em> Ewing, 1923 and <em>Neosiro</em> Newell, 1943, are resurrected, one new genus, <em>Arhesiro</em> gen. nov., a subgenus, <em>Tillamooksiro</em> sbg. nov., and two new species, <em>Holosiro</em> <em>ewingi</em> sp. n. and <em>Neosiro </em>(<em>T</em>.)<em> martensi</em> sp. n. are described. Diagnostic characters of Cyphophthalmi families are presented and discussed.

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4

Hilterman, Fred. "Maurice Ewing Medal for T. R. LaFehr." Leading Edge 17, no. 3 (1998): 385. http://dx.doi.org/10.1190/tle17030385.1.

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5

Maharjan, Yunash, Sreya Dey, Elina Mukherjee, Jessica Daley, and Kelly M. Bailey. "Abstract 5464: Galectin-3 expression in Ewing sarcoma: Modulation of the immune microenvironment in an immunocompetent model." Cancer Research 84, no. 6_Supplement (2024): 5464. http://dx.doi.org/10.1158/1538-7445.am2024-5464.

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Abstract Objective: Ewing sarcoma is an aggressive cancer of adolescents. Patients with metastatic Ewing sarcoma often receive radiation as part of their treatment protocol. We have demonstrated that both Ewing tumor cells and T cells infiltrating Ewing tumors express Galectin-3 (Gal3), an immunosuppressive protein in the tumor microenvironment. Here, we utilize an immunocompetent, humanized mouse model of Ewing sarcoma to investigate the role of Galectin-3 in the Ewing tumor immune microenvironment both at baseline and following radiation. Specifically, we sought to determine the influence of

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6

Morales, Erin, Michael Olson, Fiorella Iglesias, Saurabh Dahiya, Tim Luetkens, and Djordje Atanackovic. "Role of immunotherapy in Ewing sarcoma." Journal for ImmunoTherapy of Cancer 8, no. 2 (2020): e000653. http://dx.doi.org/10.1136/jitc-2020-000653.

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Ewing sarcoma (ES) is thought to arise from mesenchymal stem cells and is the second most common bone sarcoma in pediatric patients and young adults. Given the dismal overall outcomes and very intensive therapies used, there is an urgent need to explore and develop alternative treatment modalities including immunotherapies. In this article, we provide an overview of ES biology, features of ES tumor microenvironment (TME) and review various tumor-associated antigens that can be targeted with immune-based approaches including cancer vaccines, monoclonal antibodies, T cell receptor-transduced T c

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7

Miller, Henry E., Aparna Gorthi, Nicklas Bassani, Liesl A. Lawrence, Brian S. Iskra, and Alexander J. R. Bishop. "Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility." Cancers 12, no. 4 (2020): 948. http://dx.doi.org/10.3390/cancers12040948.

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Ewing sarcoma is an aggressive pediatric cancer of enigmatic cellular origins typically resulting from a single translocation event t (11; 22) (q24; q12). The resulting fusion gene, EWSR1-FLI1, is toxic or unstable in most primary tissues. Consequently, attempts to model Ewing sarcomagenesis have proven unsuccessful thus far, highlighting the need to identify the cellular features which permit stable EWSR1-FLI1 expression. By re-analyzing publicly available RNA-Sequencing data with manifold learning techniques, we uncovered a group of Ewing-like tissues belonging to a developmental trajectory

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8

NORTON, ROY A., and SERGEY G. ERMILOV. "Identity of the oribatid mite Oribata curva and transfer to Trichogalumna (Acari, Oribatida, Galumnidae), with discussion of nomenclatural and biogeographical issues in the ‘curva’ species-group." Zootaxa 4272, no. 4 (2017): 551. http://dx.doi.org/10.11646/zootaxa.4272.4.4.

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Based on the study of type material, other historical specimens, and new collections, the adult of the thelytokous oribatid mite Oribata curva Ewing, 1907 (Galumnidae) is redescribed and the name is recombined to Trichogalumna curva (Ewing, 1907) comb. nov. A confusing history of synonymies and misidentifications is traced in detail, and their effect on published statements about biogeography is assessed. Reliable records of T. curva are only those from North America. The tropical mite Pergalumna ventralis (Willmann, 1932) is not a subspecies of T. curva. The widely-reported Trichogalumna nipp

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9

Zhou (Joe) Huang, Yue, Melanie Rouleu, and Poul Sorensen. "Abstract B053: Tumor-associated macrophages diminishes IL1RAP-targeting CAR-T cell therapy efficacy in Ewing sarcoma." Cancer Research 84, no. 17_Supplement (2024): B053. http://dx.doi.org/10.1158/1538-7445.pediatric24-b053.

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Abstract Ewing sarcoma (EwS) is a pediatric malignancy of soft tissue and bone with a poor prognosis, especially in its metastatic stages. We have previously identified IL1RAP as a promising target for immunotherapies like chimeric antigen receptor (CAR) T cell therapy against EwS. However, CAR-T cells, despite their success in hematological cancers, often show limited efficacy against solid tumors. In orthotopic xenograft models of Ewing sarcoma (EwS) we have observed that CD11b+ CD206+ macrophages, known as tumor-associated macrophages (TAMs), surround the primary tumor. Treatment with IL1RA

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10

Daley, Jessica D., Elina M. Mukherjee, Anthony R. Cillo, et al. "Abstract A004: Radiation-induced changes to the immune microenvironment in an immunocompetent mouse model of Ewing sarcoma." Clinical Cancer Research 28, no. 18_Supplement (2022): A004. http://dx.doi.org/10.1158/1557-3265.sarcomas22-a004.

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Abstract Background: Ewing sarcoma is a rare, aggressive, fusion oncoprotein-driven pediatric cancer. Patients with upfront metastatic or surgically unresectable disease commonly undergo radiation as part of standard of care therapy. Currently, little is known about the effect of radiation specifically on the immune microenvironment of Ewing tumors, as no routine biopsies or other clinical samples are acquired during radiation. Further, historically, the field has lacked an immunocompetent mouse model of Ewing sarcoma in which to study Ewing tumor-immune cell interactions. Given our interest i

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11

Durden, Lance A., Troy L. Best, Nixon Wilson, and Clayton D. Hilton. "Ectoparasitic Mites (Acari) of Sympatric Brazilian Free-Tailed Bats and Big Brown Bats in Alabama." Journal of Medical Entomology 29, no. 3 (1992): 507–11. https://doi.org/10.5281/zenodo.13476516.

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(Uploaded by Plazi for the Bat Literature Project) Seven species of mites were recovered from 133 Brazilian free-tailed bats, Tadarida brasiliensis, and 94 big brown bats, Eptesicus [uscus, from February through November 1990 in colonies that shared roosting space in east-central Alabama. The macronyssid Chiroptonyssus robustipes (Ewing) was the most common mite on T. brasiliensis (964 mites, 87% of bats infested) and on E. fuseus (109 mites, 29% of bats infested). However, C. robustipes normally is a specific parasite of T. brasiliensis. The macronyssids Steatonyssus ceratognathus (Ewing) and

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12

Durden, Lance A., Troy L. Best, Nixon Wilson, and Clayton D. Hilton. "Ectoparasitic Mites (Acari) of Sympatric Brazilian Free-Tailed Bats and Big Brown Bats in Alabama." Journal of Medical Entomology 29, no. 3 (1992): 507–11. https://doi.org/10.5281/zenodo.13476516.

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(Uploaded by Plazi for the Bat Literature Project) Seven species of mites were recovered from 133 Brazilian free-tailed bats, Tadarida brasiliensis, and 94 big brown bats, Eptesicus [uscus, from February through November 1990 in colonies that shared roosting space in east-central Alabama. The macronyssid Chiroptonyssus robustipes (Ewing) was the most common mite on T. brasiliensis (964 mites, 87% of bats infested) and on E. fuseus (109 mites, 29% of bats infested). However, C. robustipes normally is a specific parasite of T. brasiliensis. The macronyssids Steatonyssus ceratognathus (Ewing) and

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13

Durden, Lance A., Troy L. Best, Nixon Wilson, and Clayton D. Hilton. "Ectoparasitic Mites (Acari) of Sympatric Brazilian Free-Tailed Bats and Big Brown Bats in Alabama." Journal of Medical Entomology 29, no. 3 (1992): 507–11. https://doi.org/10.5281/zenodo.13476516.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Seven species of mites were recovered from 133 Brazilian free-tailed bats, Tadarida brasiliensis, and 94 big brown bats, Eptesicus [uscus, from February through November 1990 in colonies that shared roosting space in east-central Alabama. The macronyssid Chiroptonyssus robustipes (Ewing) was the most common mite on T. brasiliensis (964 mites, 87% of bats infested) and on E. fuseus (109 mites, 29% of bats infested). However, C. robustipes normally is a specific parasite of T. brasiliensis. The macronyssids Steatonyssus ceratognathus (Ewing) and

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14

Durden, Lance A., Troy L. Best, Nixon Wilson, and Clayton D. Hilton. "Ectoparasitic Mites (Acari) of Sympatric Brazilian Free-Tailed Bats and Big Brown Bats in Alabama." Journal of Medical Entomology 29, no. 3 (1992): 507–11. https://doi.org/10.5281/zenodo.13476516.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Seven species of mites were recovered from 133 Brazilian free-tailed bats, Tadarida brasiliensis, and 94 big brown bats, Eptesicus [uscus, from February through November 1990 in colonies that shared roosting space in east-central Alabama. The macronyssid Chiroptonyssus robustipes (Ewing) was the most common mite on T. brasiliensis (964 mites, 87% of bats infested) and on E. fuseus (109 mites, 29% of bats infested). However, C. robustipes normally is a specific parasite of T. brasiliensis. The macronyssids Steatonyssus ceratognathus (Ewing) and

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15

Durden, Lance A., Troy L. Best, Nixon Wilson, and Clayton D. Hilton. "Ectoparasitic Mites (Acari) of Sympatric Brazilian Free-Tailed Bats and Big Brown Bats in Alabama." Journal of Medical Entomology 29, no. 3 (1992): 507–11. https://doi.org/10.5281/zenodo.13476516.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Seven species of mites were recovered from 133 Brazilian free-tailed bats, Tadarida brasiliensis, and 94 big brown bats, Eptesicus [uscus, from February through November 1990 in colonies that shared roosting space in east-central Alabama. The macronyssid Chiroptonyssus robustipes (Ewing) was the most common mite on T. brasiliensis (964 mites, 87% of bats infested) and on E. fuseus (109 mites, 29% of bats infested). However, C. robustipes normally is a specific parasite of T. brasiliensis. The macronyssids Steatonyssus ceratognathus (Ewing) and

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16

Town, Jennifer, Helio Pais, Sally Harrison, et al. "Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target." Proceedings of the National Academy of Sciences 113, no. 13 (2016): 3603–8. http://dx.doi.org/10.1073/pnas.1521251113.

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The cell surface proteome of tumors mediates the interface between the transformed cells and the general microenvironment, including interactions with stromal cells in the tumor niche and immune cells such as T cells. In addition, the cell surface proteome of individual cancers defines biomarkers for that tumor type and potential proteins that can be the target of antibody-mediated therapy. We have used next-generation deep RNA sequencing (RNA-seq) coupled to an in-house database of genes encoding cell surface proteins (herein referred to as the surfaceome) as a tool to define a cell surface p

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17

Cheung, Carol C., Rita A. Kandel, Robert S. Bell, Raymond E. Mathews, and Danny M. D. Ghazarian. "Extraskeletal Ewing Sarcoma in a 77-Year-Old Woman." Archives of Pathology & Laboratory Medicine 125, no. 10 (2001): 1358–60. http://dx.doi.org/10.5858/2001-125-1358-eesiay.

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Abstract Extraskeletal Ewing sarcoma (EES) is a rare soft tissue tumor that is morphologically indistinguishable from Ewing sarcoma of bone. It is usually found in young people, but several cases have occurred in patients older than 50 years. The differential diagnoses include other small, blue round cell tumors (SBRCTs) and other members of the Ewing family of tumors such as the primitive neuroectodermal tumor. We present a case of EES in the left inguinal region of a 77-year-old woman. The tumor was distinguished from other SBRCTs by lack of immunoreactivity for epithelial, lymphoid, vascula

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18

Li, Xianchan. "Understanding Neurotransmission Using Single Vesicle Electrochemistry." ECS Meeting Abstracts MA2023-02, no. 63 (2023): 2958. http://dx.doi.org/10.1149/ma2023-02632958mtgabs.

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Exocytosis is one of the essential steps for chemical signal transmission between neurons. In this process, vesicle docks and fuses with the plasma membrane and release the stored neurotransmitters through exocytotic pore into the extracellular space, and all of these steps are governed with various molecules, such as proteins, ions and even lipids. Quantitatively monitoring vesicular neurotransmitter release in exocytosis and initial neurotransmitter storage in individual vesicles are significant in order to study mechanisms of neurotransmission and malfunction in disease. Recently, we develo

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19

Pesenti, Tatiana C., Sâmara N. Gomes, Ana M. Rui, and Gertrud Müller. "Geographic variation in ectoparasitic mites diversity in Tadarida Brasiliensis (Chiroptera, Molossidae)." Iheringia. Série Zoologia 104, no. 4 (2014): 451–56. http://dx.doi.org/10.1590/1678-476620141044451456.

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Tadarida brasiliensis (Geoffroy, 1824), the Brazilian free-tailed bat, is an insectivorous bat that occurs from southern United States of America to southern South America. In this study we present the first data on diversity of ectoparasitic mites of T. brasiliensis in Brazil. A compilation and analysis of the studies of mite diversity conducted in different points the geographic distribution this bat species are provided. The mites were collected from March 2010 to November 2011 on 160 T. brasiliensis adult bats captured in southern Brazil. Four species of mites have been found: Chiroptonyss

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20

Pesenti, Tatiana C., Sâmara N. Gomes, Ana M. Rui, and Gertrud Müller. "Geographic variation in ectoparasitic mites diversity in Tadarida Brasiliensis (Chiroptera, Molossidae)." Iheringia. Série Zoologia 104, no. 4 (2014): 451–56. https://doi.org/10.5281/zenodo.13436289.

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(Uploaded by Plazi for the Bat Literature Project) Tadarida brasiliensis (Geoffroy, 1824), the Brazilian free-tailed bat, is an insectivorous bat that occurs from southern United States of America to southern South America. In this study we present the first data on diversity of ectoparasitic mites of T. brasiliensis in Brazil. A compilation and analysis of the studies of mite diversity conducted in different points the geographic distribution this bat species are provided. The mites were collected from March 2010 to November 2011 on 160 T. brasiliensis adult bats captured in southern Brazil.

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21

Pesenti, Tatiana C., Sâmara N. Gomes, Ana M. Rui, and Gertrud Müller. "Geographic variation in ectoparasitic mites diversity in Tadarida Brasiliensis (Chiroptera, Molossidae)." Iheringia. Série Zoologia 104, no. 4 (2014): 451–56. https://doi.org/10.5281/zenodo.13436289.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Tadarida brasiliensis (Geoffroy, 1824), the Brazilian free-tailed bat, is an insectivorous bat that occurs from southern United States of America to southern South America. In this study we present the first data on diversity of ectoparasitic mites of T. brasiliensis in Brazil. A compilation and analysis of the studies of mite diversity conducted in different points the geographic distribution this bat species are provided. The mites were collected from March 2010 to November 2011 on 160 T. brasiliensis adult bats captured in southern Brazil.

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22

Pesenti, Tatiana C., Sâmara N. Gomes, Ana M. Rui, and Gertrud Müller. "Geographic variation in ectoparasitic mites diversity in Tadarida Brasiliensis (Chiroptera, Molossidae)." Iheringia. Série Zoologia 104, no. 4 (2014): 451–56. https://doi.org/10.5281/zenodo.13436289.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Tadarida brasiliensis (Geoffroy, 1824), the Brazilian free-tailed bat, is an insectivorous bat that occurs from southern United States of America to southern South America. In this study we present the first data on diversity of ectoparasitic mites of T. brasiliensis in Brazil. A compilation and analysis of the studies of mite diversity conducted in different points the geographic distribution this bat species are provided. The mites were collected from March 2010 to November 2011 on 160 T. brasiliensis adult bats captured in southern Brazil.

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23

Pesenti, Tatiana C., Sâmara N. Gomes, Ana M. Rui, and Gertrud Müller. "Geographic variation in ectoparasitic mites diversity in Tadarida Brasiliensis (Chiroptera, Molossidae)." Iheringia. Série Zoologia 104, no. 4 (2014): 451–56. https://doi.org/10.5281/zenodo.13436289.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Tadarida brasiliensis (Geoffroy, 1824), the Brazilian free-tailed bat, is an insectivorous bat that occurs from southern United States of America to southern South America. In this study we present the first data on diversity of ectoparasitic mites of T. brasiliensis in Brazil. A compilation and analysis of the studies of mite diversity conducted in different points the geographic distribution this bat species are provided. The mites were collected from March 2010 to November 2011 on 160 T. brasiliensis adult bats captured in southern Brazil.

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24

Pesenti, Tatiana C., Sâmara N. Gomes, Ana M. Rui, and Gertrud Müller. "Geographic variation in ectoparasitic mites diversity in Tadarida Brasiliensis (Chiroptera, Molossidae)." Iheringia. Série Zoologia 104, no. 4 (2014): 451–56. https://doi.org/10.5281/zenodo.13436289.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Tadarida brasiliensis (Geoffroy, 1824), the Brazilian free-tailed bat, is an insectivorous bat that occurs from southern United States of America to southern South America. In this study we present the first data on diversity of ectoparasitic mites of T. brasiliensis in Brazil. A compilation and analysis of the studies of mite diversity conducted in different points the geographic distribution this bat species are provided. The mites were collected from March 2010 to November 2011 on 160 T. brasiliensis adult bats captured in southern Brazil.

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25

Shibasaki, Maiko, Toshinori Iwai, Jiro Maegawa, et al. "Mandibular Ewing Sarcoma With Chromosomal Translocation t(21;22)(q22;q12)." Journal of Craniofacial Surgery 24, no. 4 (2013): 1469–72. http://dx.doi.org/10.1097/scs.0b013e31829030ed.

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26

Pawar, Ravikiran Narayansing, Debadrita Ray, Sankalp Sancheti, et al. "Rare cytogenetic subtype in a case of Ewing sarcoma with diagnostic dilemma: A case report." Journal of Hematology and Allied Sciences 5 (February 13, 2025): 96–98. https://doi.org/10.25259/jhas_52_2024.

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Ewing sarcoma is aggressive tumor with round cell morphology and very common in <15 years of age and young adults. Overall, incidence ranges from 10 to 15% of all the bone sarcomas. Ewing sarcoma most commonly affects lower extremity especially femur and other sites includes pelvis, upper extremity, and axial skeleton and ribs. The tumor cells are round blue cells on routine microscopy and the close differential includes other soft-tissue tumors such as primitive neuroectodermal tumor and neuroepithelioma. In addition to histology, the ancillary tests such as immunohistochemistry and cytoge

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27

Vasileva, Elena, Claire Arata, Gage Crump, and James Amatruda. "Abstract A022 Characterizing the cell of origin of Ewing sarcoma." Cancer Research 84, no. 17_Supplement (2024): A022. http://dx.doi.org/10.1158/1538-7445.pediatric24-a022.

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Abstract Ewing sarcoma (ES) is a malignant bone and soft tissue tumor that affects children, adolescents, and young adults. ES is characterized by the presence of a driver fusion oncogene, most frequently EWSR1-FLI1. The cell of origin of Ewing sarcoma and the mechanisms of EWSR1-FLI1-driven cell transformation are the subjects of long-standing debates, largely due to the absence of a representative mouse model. Previous reports have suggested that bone-marrow mesenchyme or/and neural crest cells may serve as potential cells of origin for Ewing sarcoma. These hypotheses have never been tested

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28

Forootan, Amin, Daniel Andersson, Soheila Dolatabadi, David Svec, José Andrade, and Anders Ståhlberg. "Identification of Distinct and Common Subpopulations of Myxoid Liposarcoma and Ewing Sarcoma Cells Using Self-Organizing Maps." Chemosensors 11, no. 1 (2023): 67. http://dx.doi.org/10.3390/chemosensors11010067.

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Myxoid liposarcoma and Ewing sarcoma are the two most common tumor types that are characterized by the FET (FUS, EWSR1 and TAF15) fusion oncogenes. These FET fusion oncogenes are considered to have the same pathological mechanism. However, the cellular similarities between cells from the different tumor entities remain unknown. Here, we profiled individual myxoid liposarcoma and Ewing sarcoma cells to determine common gene expression signatures. Five cell lines were analyzed, targeting 76 different genes. We employed unsupervised clustering, focusing on self-organizing maps, to identify biolog

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29

Khoddami, Maliheh, Jeremy Squire, Maria Zielenska, and Paul Thorner. "Melanotic Neuroectodermal Tumor of Infancy: A Molecular Genetic Study." Pediatric and Developmental Pathology 1, no. 4 (1998): 295–99. http://dx.doi.org/10.1007/s100249900042.

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Melanotic neuroectodermal tumor of infancy is a rare but well-recognized entity in pediatric pathology. However, the relationship of this tumor to other pediatric small cell tumors with neuroectodermal features (such as neuroblastoma, Ewing sarcoma/peripheral primitive neuroectodermal tumor, and desmoplastic small round cell tumor) is undetermined. Molecular genetic studies of melanotic neuroectodermal tumor of infancy have not been reported. We studied three typical cases of mela-notic neuroectodermal tumor of infancy in an attempt to link this tumor to other small cell tumors with well-chara

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30

You, Yang, Xi Guo, Rongyuan Zhuang, et al. "Genomic co-genotype classification and clinical prognosis in Ewing sarcoma." Journal of Clinical Oncology 40, no. 16_suppl (2022): e23532-e23532. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e23532.

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e23532 Background: Ewing sarcoma is a highly aggressive round cell mesenchymal tumor that commonly occurs in children and young adults. It is molecularly characterized by chromosomal translocations, most commonly t (11;22), resulting in the abnormal EWSR1-FLI1 fusion. In addition to EWSR1-FLI1, patients may have other genomic variants that can be used for risk stratification. In the present study, we retrospectively investigated the association between co-variant genes and prognosis in patients with Ewing sarcoma. Methods: From 2019 to 2021, 10 patients with Ewing sarcoma were enrolled in the

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31

Vasileva, Elena, Claire Arata, Gage Crump, and James Amatruda. "Abstract 114: Unraveling the origin of Ewing sarcoma using zebrafish transgenic models." Cancer Research 85, no. 8_Supplement_1 (2025): 114. https://doi.org/10.1158/1538-7445.am2025-114.

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Abstract Ewing sarcoma (ES) is a pediatric cancer of bones and soft tissues with enigmatic origin. Ewing sarcoma cells are characterized by the presence of a driver fusion oncogene, most frequently EWSR1-FLI1. Previous reports have suggested that bone-marrow mesenchyme or/and neural crest cells may serve as potential cells of origin for Ewing sarcoma. These hypotheses have never been tested in vivo, largely due to the absence of a representative mouse model as the EWSR1-FLI1 fusion causes severe developmental toxicity in most cell types. To address these questions, we developed a stable zebraf

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32

Barodawala, Shaikhali, Gayatri Soneta, Kirti Chadha, Gauri Pradhan, Pooja Parab, and Shibani Ramchandran. "Adamantinoma-like Ewing Sarcoma: A Report of Two Rare Cases in the Pancreatic Tail and Spine." Journal of Cancer and Tumor International 14, no. 4 (2024): 134–42. http://dx.doi.org/10.9734/jcti/2024/v14i4275.

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Adamantinoma-like Ewing sarcoma (ALES), an extremely rare variant of Ewings sarcoma occurs primarily in the head and neck sites. ALES is characterized by basaloid cytomorphology, immunohistochemically expresses keratins, p63, p40, CD99, and harbors t (11; 22) EWSR1::FLI1 translocation on fluorescence in situ hybridization (FISH). The current case report discusses two cases of ALES, one in the pancreatic tail of a 64-year-old male and the second in the lumbar spine of an 18 yr old male. The IHC for both cases showed similar picture, confirming ALES through Fluorescence in situ hybridization (FI

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33

Bhatia, Smita, Mark D. Krailo, Zhengjia Chen, et al. "Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: a report from the Children's Oncology Group." Blood 109, no. 1 (2006): 46–51. http://dx.doi.org/10.1182/blood-2006-01-023101.

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Abstract This study describes the magnitude of risk of therapy-related myelodysplasia and acute myeloid leukemia (t-MDS/AML) in 578 individuals diagnosed with Ewing sarcoma and enrolled on Children's Oncology Group therapeutic protocol, INT-0091. Between 1988 and 1992, patients with or without metastatic disease were randomized to receive doxorubicin, vincristine, cyclophosphamide, and dactinomycin (regimen A) or these 4 drugs alternating with etoposide and ifosfamide (regimen B). Between 1992 and 1994, patients with metastatic disease were nonrandomly assigned to receive high-intensity therap

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Louati, Sara, Nadia Senhaji, Laila Chbani, and Sanae Bennis. "EWSR1 Rearrangement and CD99 Expression as Diagnostic Biomarkers for Ewing/PNET Sarcomas in a Moroccan Population." Disease Markers 2018 (September 18, 2018): 1–5. http://dx.doi.org/10.1155/2018/7971019.

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Ewing sarcoma/primitive neuroectodermal tumor (Ewing/PNET sarcomas or EPS) are a group of round cell tumors. Malignant round cell tumors form a large and diverse group that includes rhabdomyosarcoma, synovial sarcoma, non-Hodgkin’s lymphoma, neuroblastoma, hepatoblastoma, Wilm’s tumor, desmoplastic small round cell tumor, and other morphologically similar entities. Differential diagnosis of Ewing sarcoma/primitive neuroectodermal tumor (Ewing/PNET sarcomas or EPS) is difficult. In addition to morphology and immunohistochemistry (IHC), differential diagnosis of these tumors is based on molecula

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Bulbul, Ajaz, John Paul Shen, Joanne Xiu, Pablo Tamayo, and Hatim Husain. "Genomic and Proteomic Alterations in Desmoplastic Small Round Blue-Cell Tumors." JCO Precision Oncology, no. 2 (November 2018): 1–9. http://dx.doi.org/10.1200/po.17.00170.

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Purpose Desmoplastic small round blue-cell tumors (DSRCTs) are sarcomas that contain the t(11;22) (p13;q12) translocation EWS-WT1 fusion protein. Because this is a rare tumor type, prospective clinical trials in DSRCT are challenging. Patients are treated in a manner similar to those with Ewing sarcoma; however, differences in prognosis and clinical presentation suggest fundamental differences in biology and potentially different therapeutic implications. This study aimed to characterize the molecular characteristics of DSRCT tumors to explore unique therapeutic options for this extremely rare

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Ranft, Andreas, Corinna Winter, Christiane Hoffmann, et al. "Long-term outcome of patients with lower extremity Ewing sarcoma." Journal of Clinical Oncology 35, no. 5_suppl (2017): 117. http://dx.doi.org/10.1200/jco.2017.35.5_suppl.117.

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117 Background: With improved survival rates of patients with Ewing sarcoma the quality of long-term survivorship needs to be addressed. In this study, general recovery and restitution of function following intensive bone tumor treatment were analyzed by assessing the clinico-functional outcome and physical activity using self-reporting and objective measurement tools. Methods: Long-term outcome of 224 former patients with lower extremity Ewing sarcoma, registered between 1980 and 2009 in consecutive clinical trials of the GPOH, were assessed using the TESS, SF-36, BSI, and RSES questionnaire

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Staege, Martin S., and Daniela Max. "Genetics and Epigenetics of the TET-ETS Translocation Network." Genetics & Epigenetics 2 (January 2009): GEG.S2815. http://dx.doi.org/10.4137/geg.s2815.

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In the present paper we review the translocation network involving TET and ETS family members with special focus on the Ewing family of tumors. FUS (fusion, involved in t(12;16) in malignant liposarcoma = TLS, Translocated in liposarcoma), EWSR1 (Ewing sarcoma breakpoint region 1) and TAF15 (TATA box-binding protein-associated factor, 68-KD) are the three human members of the TET family of RNA binding proteins. In addition, two EWSR1 pseudogenes are present in the human genome. TET family members are involved in several oncogenic gene fusions. Five of the 18 known fusion partners belong to the

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Anderson, Peter M., Zheng Jin Tu, Scott E. Kilpatrick, Matteo Trucco, Rabi Hanna, and Timothy Chan. "Routine EWS Fusion Analysis in the Oncology Clinic to Identify Cancer-Specific Peptide Sequence Patterns That Span Breakpoints in Ewing Sarcoma and DSRCT." Cancers 15, no. 5 (2023): 1623. http://dx.doi.org/10.3390/cancers15051623.

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(1) Background: EWS fusion genes are associated with Ewing sarcoma and other Ewing family tumors including desmoplastic small round tumor, DSRCT. We utilize a clinical genomics workflow to reveal real-world frequencies of EWS fusion events, cataloging events that are similar, or divergent at the EWS breakpoint. (2) Methods: EWS fusion events from our next-generation sequencing panel (NGS) samples were first sorted by breakpoint or fusion junctions to map out the frequency of breakpoints. Fusion results were illustrated as in-frame fusion peptides involving EWS and a partner gene. (3) Results:

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Idrees, Muhammad, Chirag Gandhi, Simone Betchen, James Strauchen, Wesley King, and David Wolfe. "Intracranial Peripheral Primitive Neuroectodermal Tumors of the Cavernous Sinus: A Diagnostic Peculiarity." Archives of Pathology & Laboratory Medicine 129, no. 1 (2005): e11-e15. http://dx.doi.org/10.5858/2005-129-e11-ippnto.

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Abstract Peripheral primitive neuroectodermal tumors (pPNETs) are aggressive, poorly differentiated neoplasms that occur in children and young adults. These tumors are associated with a peak incidence in the second decade and a slight male preponderance. Recently, Ewing sarcoma and pPNET tumors have been proven to carry identical translocations, the most common being t(11;22)(q24;q12). Intracranial Ewing sarcoma/pPNETs have rarely been described in the literature. We studied a case of intracranial pPNET arising in the right cavernous sinus of a 46-year-old man. On imaging, the tumor had both s

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Ellis, Mark A., Daniel R. Gerry, David M. Neskey, and Eric J. Lentsch. "Ewing Sarcoma of the Head and Neck." Annals of Otology, Rhinology & Laryngology 126, no. 3 (2017): 179–84. http://dx.doi.org/10.1177/0003489416681322.

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Objectives: Ewing sarcoma is a rare tumor of the head and neck. Previous efforts to characterize Ewing sarcoma of the head and neck (ES-HN) have been limited to small retrospective series. The objective of this study was to analyze the demographic, clinicopathologic, treatment, and survival characteristics of ES-HN compared to Ewing sarcoma at other locations (ES-other). Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database, we compared 183 patients with ES-HN to 3177 patients with ES-other. Patient characteristics were analyzed with chi-square or t test. Ten-year dise

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Mous, Lieke, Michelle Hofer, Dorita Zabėlė, et al. "Abstract A009: Synthetic lethality in the context of STAG2-mutant Ewing sarcoma." Molecular Cancer Therapeutics 23, no. 6_Supplement (2024): A009. http://dx.doi.org/10.1158/1538-8514.synthleth24-a009.

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Abstract Introduction: Ewing sarcoma is an aggressive type of pediatric bone cancer, characterized by a fusion transcription factor (EWSR1-FLI1 in 85% of cases1,2). Recurrent secondary mutations are limited to alterations in TP53, CDKN2A and most frequently STAG2 (15-22%3-6). STAG2-loss-of-function (LOF) mutations correlate with poor prognosis, metastasis and relapse3,5,6, and are shown to induce a metastatic phenotype in preclinical studies7,8. Despite intensive multimodal treatment (surgery, radiation and chemotherapy), the estimated 5-year survival is a mere 65-75% for patients with localiz

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Olaoye, Olasunkanmi, Colleen Harrington, Kenneth N. Ross, et al. "Abstract 3169: Dependency-agnostic drug discovery: A dual-screening strategy to uncover novel cancer vulnerabilities." Cancer Research 85, no. 8_Supplement_1 (2025): 3169. https://doi.org/10.1158/1538-7445.am2025-3169.

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The current landscape of small-molecule drug discovery prioritizes genetic dependencies considered as viable protein targets. While this approach has driven significant therapeutic advancements, it has also constrained the exploration of non-dependency targets harboring tractable vulnerabilities. Moreover, many genetic dependencies remain undruggable, precluding their therapeutic exploitation and leaving critical gaps in addressing cancers with unmet clinical needs. To overcome these limitations, we developed a tandem screening approach that integrates large-scale chemical and genetic screens

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Polimera, Hyma, Prashanth Moku, Shady Piedra Abusharar, Monali Vasekar, and Jayakrishna Chintanaboina. "Metastasis of Ewing Sarcoma to the Pancreas: Case Report and Literature Review." Case Reports in Oncological Medicine 2020 (March 21, 2020): 1–9. http://dx.doi.org/10.1155/2020/7075048.

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Ewing sarcoma (ES) is a highly aggressive malignant bone cancer. ES is part of the Ewing sarcoma family of tumors (ESFT), which express characteristic t(11;22) translocation as well as higher levels of CD99. Given that metastasis and tumor burden are significant prognostic factors in patient’s response to treatment, prompt diagnosis is needed to effectively treat ESFT patients. However, the challenges in classifying and characterizing ESFT complicate effective management and treatment of ES. In this report, we present a rare case of ES metastasis to the pancreas. Upon review of the literature,

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Gunawardena, I., D. Kenwright, N. Steventon, and C. Ferguson. "Primitive neuroectodermal tumour of the tongue." Journal of Laryngology & Otology 122, no. 4 (2007): 416–18. http://dx.doi.org/10.1017/s0022215107005129.

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AbstractPeripheral primitive neuroectodermal tumours, which belong to the Ewing sarcoma tumour family, are extremely rare. These tumours are highly aggressive and are known to have a poor prognosis. Immunostaining with at least two neural markers and evidence of an abnormal t(11;22)(q24;q12) translocation are hallmark features in this diagnosis. We present the first reported case of peripheral primitive neuroectodermal tumour to occur in the tongue.

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Nilsson, Gunnar, Min Wang, Johan Wejde, Andris Kreicbergs, and Olle Larsson. "Detection of EWS/FLI-1 by Immunostaining. An Adjunctive Tool in Diagnosis of Ewing's Sarcoma and Primitive Neuroectodermal Tumour on Cytological Samples and Paraffin-Embedded Archival Material." Sarcoma 3, no. 1 (1999): 25–32. http://dx.doi.org/10.1080/13577149977839.

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Purpose.Recently we showed that the 68-kDa fusion protein derived from theEWS/FLI1hybrid gene can be specifically detected by Western blotting using a polyclonal antibody to the C-terminal of FLI1 on biopsy material from Ewing's sarcoma. The aim of this study was to investigate whether this antibody also could be used for immunocytochemistry and immunohistochemistry in diagnosis of Ewing's sarcoma.Methods.Immunostaining on paraffin-embedded archival material, fine-needle aspirates and tumour touch imprints from Ewing's sarcomas and primitive neuroectodermal tumours (PNET) for detection of the

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Yasir, Muhammad, Jinyoung Park, Eun-Taek Han, et al. "Exploration of Flavonoids as Lead Compounds against Ewing Sarcoma through Molecular Docking, Pharmacogenomics Analysis, and Molecular Dynamics Simulations." Molecules 28, no. 1 (2023): 414. http://dx.doi.org/10.3390/molecules28010414.

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Ewing sarcoma (ES) is a highly malignant carcinoma prevalent in children and most frequent in the second decade of life. It mostly occurs due to t(11;22) (q24;q12) translocation. This translocation encodes the oncogenic fusion protein EWS/FLI (Friend leukemia integration 1 transcription factor), which acts as an aberrant transcription factor to deregulate target genes essential for cancer. Traditionally, flavonoids from plants have been investigated against viral and cancerous diseases and have shown some promising results to combat these disorders. In the current study, representative flavono

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Lauricella, Eleonora, Anna Manicone, Federica Cavallo, et al. "Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review." Therapeutic Advances in Medical Oncology 15 (January 2023): 175883592311659. http://dx.doi.org/10.1177/17588359231165979.

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Adamantinoma-like Ewing sarcoma (ALES) of the salivary glands is an exceedingly rare malignancy defined by the t(11,22) EWSR1::FLI1 fusion, with complex epithelial differentiation. To identify features that can allow for better recognition of this disease entity, we reviewed all published reports of molecularly confirmed ALES of the salivary glands and explored epidemiological, clinical, radiological, pathological, and therapeutic characteristics of a population of 21 patients including a single newly reported patient from our group. We searched the English-language literature indexed in PubMe

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Schulz, Evan, and Mizuki Azuma. "Abstract 2621: Mitotic activities of Ewing sarcoma proteins." Cancer Research 85, no. 8_Supplement_1 (2025): 2621. https://doi.org/10.1158/1538-7445.am2025-2621.

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Ewing sarcoma (ES) is a pediatric bone tumor in critical need of targeted chemotherapies with fewer side effects. ES’s driving hallmark, the t(11:22) chromosomal translocation, generates two aberrations of the EWS protein: the loss of an EWS allele and expression of EWS/FLI1 fusion protein, denoted as EWS aberrations. Identifying drug targetable EWS aberration-induced changes to tumor biology and drug sensitivity is required to optimize current treatment strategies and develop new targeted therapies. To accomplish this, we established a DLD-1 cell line that lacks the t(11:22) chromosomal trans

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LOFEGO, A. C., R. OCHOA, and G. J. MORAES. "Some tarsonemid mites (Acari: Tarsonemidae) from the Brazilian "Cerrado" vegetation, with descriptions of three new species." Zootaxa 823, no. 1 (2005): 1. http://dx.doi.org/10.11646/zootaxa.823.1.1.

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Seven tarsonemid species were found in leaf samples from the "Cerrado" vegetation in the State of São Paulo in southeastern Brazil. Mensuration data of four species, Daidalotarsonemus tesselatus De Leon, Tarsonemus bilobatus Suski, Tarsonemus confusus Ewing and T. waitei Banks are provided. Three new species, Daidalotarsonemus folisetae Lofego & Ochoa, Metatarsonemus megasolenidii Lofego & Ochoa and Tarsonemus longisetae Lofego & Ochoa are described. Food habits of D. tesselatus are discussed.

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Zhao, L. "Detection of a novel reciprocal t(16;22)(q11.2;q12) in a Ewing sarcoma." Cancer Genetics and Cytogenetics 140, no. 1 (2003): 55–57. http://dx.doi.org/10.1016/s0165-4608(02)00637-4.

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