Relevant bibliographies by topics / Ex vivo hair growth

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Ex vivo hair growth'

Author: Grafiati
Published: 4 June 2025
Last updated: 23 June 2025

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Journal articles on the topic "Ex vivo hair growth"

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Hundt, Jennifer E., Stephanie Sass, Wolfgang Funk, et al. "Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo." Skin Pharmacology and Physiology 32, no. 6 (2019): 344–48. http://dx.doi.org/10.1159/000501729.

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Fernández-Martos, Sandra, María Calvo-Sánchez, Karla García-Alonso, Begoña Castro, Bita Hashtroody, and Jesús Espada. "Sustained Human Hair Follicle Growth Ex Vivo in a Glycosaminoglycan Hydrogel Matrix." International Journal of Molecular Sciences 20, no. 7 (2019): 1741. http://dx.doi.org/10.3390/ijms20071741.

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Glycosaminoglycans (GAGs) and associated proteoglycans have important functions in homeostatic maintenance and regenerative processes (e.g., wound repair) of the skin. However, little is known about the role of these molecules in the regulation of the hair follicle cycle. Here we report that growing human hair follicles ex vivo in a defined GAG hydrogel mimicking the dermal matrix strongly promotes sustained cell survival and maintenance of a highly proliferative phenotype in the hair bulb and suprabulbar regions. This significant effect is associated with the activation of WNT/β-catenin signaling targets (CCDN1, AXIN2) and with the expression of stem cell markers (CK15, CD34) and growth factors implicated in the telogen/anagen transition (TGFβ2, FGF10). As a whole, these results point to the dermal GAG matrix as an important component in the regulation of the human hair follicle growth cycle, and to GAG-based hydrogels as potentially relevant modulators of this process both in vitro and in vivo.
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Kwon, Oh Sang, Jun Kyu Oh, Mi Hyang Kim, et al. "Human hair growth ex vivo is correlated with in vivo hair growth: selective categorization of hair follicles for more reliable hair follicle organ culture." Archives of Dermatological Research 297, no. 8 (2005): 367–71. http://dx.doi.org/10.1007/s00403-005-0619-z.

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Haslam, Iain S., Jonathan A. Hardman, and Ralf Paus. "Topically Applied Nicotinamide Inhibits Human Hair Follicle Growth Ex Vivo." Journal of Investigative Dermatology 138, no. 6 (2018): 1420–22. http://dx.doi.org/10.1016/j.jid.2017.12.019.

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Bacqueville, Daniel, Marguerite Lévêque, Camille Mas, et al. "New Plant Extracts Exert Complementary Anti‐Hair Loss Properties in Human In Vitro and Ex Vivo Models." Journal of Cosmetic Dermatology 23, S5 (2024): 1–11. http://dx.doi.org/10.1111/jocd.16616.

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ABSTRACTBackgroundHair loss is linked to dysfunction of the growth (anagen), regression (catagen) and rest (telogen) phases of the hair follicle (HF) cycle.AimsTo evaluate the effects of a Silybum marianum extract (SME), manganese PCA (MnPCA), and a Lespedeza capitata extract (LCE) on markers of hair growth and anchorage in human follicle dermal papilla cells (HFDPCs), and to investigate the ability of a topical serum containing these active ingredients to improve HF growth in an ex vivo human scalp skin model.MethodsIn HFDPCs, we assessed receptor tyrosine kinase phosphorylation and Wnt/β‐catenin pathway activation; quantified versican, vascular endothelial growth factor (VEGF) and Dickkopf‐1 (DDK1) secretion; and evaluated 5α‐reductase (5αR) activity. Using scalp skin biopsies from two female donors, we measured hair shaft elongation, analyzed hair matrix keratinocyte proliferation and apoptosis, and determined HF cycle stage and score.ResultsCompared to untreated HFDPCs, SME upregulated phosphorylation of growth factor receptors (EGFR:1.9 × and PDGFR: 2.8 ×) and their downstream effectors (ERK, GSK3, Akt, and STAT: 1.2–2.0 ×); MnPCA enhanced versican (33.0 ×) and VEGF (3.3 ×) secretion, and stimulated the Wnt/β‐catenin pathway (+80%); and LCE reduced DKK1 secretion (−72%) and 5αR activity (dihydrotestosterone/testosterone ratio: −60%). Compared to untreated scalp skin biopsies, the serum enhanced hair shaft elongation (+102%), and significantly prolonged the anagen phase by improving hair cycle scores and stimulating hair matrix keratinocyte proliferation (+58%).ConclusionsSME, MnPCA, and LCE displayed complementary anti‐hair loss properties. The serum combining these active ingredients may be useful in hair loss treatment.
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Alam, Majid, Diana A. Below, Jérémy Chéret, et al. "Growth Hormone Operates as a Neuroendocrine Regulator of Human Hair Growth Ex Vivo." Journal of Investigative Dermatology 139, no. 7 (2019): 1593–96. http://dx.doi.org/10.1016/j.jid.2018.12.022.

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McElwee, Kevin J., Andrea Huth, Sabine Kissling, and Rolf Hoffmann. "Macrophage-Stimulating Protein Promotes Hair Growth Ex Vivo and Induces Anagen from Telogen Stage Hair Follicles In Vivo." Journal of Investigative Dermatology 123, no. 1 (2004): 34–40. http://dx.doi.org/10.1111/j.0022-202x.2004.22712.x.

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Kim, Jaeyoon, Jae young Shin, Yun-Ho Choi, et al. "Hair Thickness Growth Effect of Adenosine Complex in Male-/Female-Patterned Hair Loss via Inhibition of Androgen Receptor Signaling." International Journal of Molecular Sciences 25, no. 12 (2024): 6534. http://dx.doi.org/10.3390/ijms25126534.

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Aging (senescence) is an unavoidable biological process that results in visible manifestations in all cutaneous tissues, including scalp skin and hair follicles. Previously, we evaluated the molecular function of adenosine in promoting alopecia treatment in vitro. To elucidate the differences in the molecular mechanisms between minoxidil (MNX) and adenosine, gene expression changes in dermal papilla cells were examined. The androgen receptor (AR) pathway was identified as a candidate target of adenosine for hair growth, and the anti-androgenic activity of adenosine was examined in vitro. In addition, ex vivo examination of human hair follicle organ cultures revealed that adenosine potently elongated the anagen stage. According to the severity of alopecia, the ratio of the two peaks (terminal hair area/vellus hair area) decreased continuously. We further investigated the adenosine hair growth promoting effect in vivo to examine the hair thickness growth effects of topical 5% MNX and the adenosine complex (0.75% adenosine, 1% penthenol, and 2% niacinamide; APN) in vivo. After 4 months of administration, both the MNX and APN group showed significant increases in hair density (MNX + 5.01% (p < 0.01), APN + 6.20% (p < 0.001)) and thickness (MNX + 5.14% (p < 0.001), APN + 10.32% (p < 0.001)). The inhibition of AR signaling via adenosine could have contributed to hair thickness growth. We suggest that the anti-androgenic effect of adenosine, along with the evaluation of hair thickness distribution, could help us to understand hair physiology and to investigate new approaches for drug development.
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Le Riche, A., J. Nienhaus, M. Sousa, et al. "1420 Ashwagandha-derived exosome-like nanoparticles promote human hair growth ex vivo." Journal of Investigative Dermatology 143, no. 5 (2023): S243. http://dx.doi.org/10.1016/j.jid.2023.03.1436.

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Trivedi, Dahryn, and Snehasis Jana. "In vivo Hair Growth Promotion Efficacy of Biofield Energy Treatment in C57BL/6 Mice." Letters in Health and Biological Sciences 3, no. 2 (2018): 51–55. https://doi.org/10.15436/2475-6245.18.2031.

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Hair loss directly impacts people&rsquo;s social interactions and also affects psychological well-being. Hair fall has been a rising trend nowadays due to dynamic lifestyle and pollution. In this context,the present study was performed to identify the potential of the Biofield Energy Healing (The Trivedi Effect&reg;) Treated test item (mixture of herbal ex-tracts of Phyllantus emblica and Eclipta alba in 1:1 ratio) on the telogen skin of mice for the assessment of haircell growth and development in vivo. The test item was divided into two parts. One part was denoted as the untreated test item without any Biofield Energy Treatment, while the other part was defined as the Biofield Energy Treated test item, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Dahryn Trivedi. The study parameters like anagen induction and visual melanogenesis were performed using skin biopsy technique. The experimental results of the untreated and Biofield Energy Treated test item groups showed hair growth with 50% and 60%, respectively on dorsal clipped of skin after topical application. Besides, the Biofield Energy Treated test item group exhibited 60% melanogenesis after biopsy analysis in mice skin at the end of the experiment. The overall results demonstrated that the Biofield Energy Treatment has the potential for hair growth promotion as evident via increased hair growth and melanogenesis. Therefore, the Biofield Energy Healing (The Trivedi Effect&reg;) Treatment could be useful as a hair growth promoter for various treatments of skin injuries and skin-related disorders like necrotizing fasciitis, actinic keratosis, sebaceous cysts, diaper rash, decubitus ulcer, etc. <strong>Source</strong>: https://www.trivedieffect.com/science/in-vivo-hair-growth-promotion-efficacy-of-biofield-energy-treatment-in-c57bl6-mice/ https://www.ommegaonline.org/article-details/In-vivo-Hair-Growth-Promotion-Efficacy-of-Biofield-Energy-Treatment-in-C57BL6-Mice/2031
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Dissertations / Theses on the topic "Ex vivo hair growth"

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Haylock, David Norman. "Ex vivo expansion of human haemopoietic progenitor cells." Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phh4181.pdf.

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"December 2001." Includes bibliographical references (leaves 178-225) Focuses on the ex vivo growth of human haemopoietic progenitor cells with the objective of defining culture conditions for generating myeloid post-progenitor cells for therapy
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Ang, Main-fong, and 洪明楓. "Ex vivo expansion of hematopoietic stem cells: preclinical studies and clinical application." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B3122815X.

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Kwok, Ka-yin, and 郭家賢. "Ex vivo expansion, microRNA expression and immortalization of CD34⁺ cells derived from human umbilical cord blood." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43572145.

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Kwok, Ka-yin. "Ex vivo expansion, microRNA expression and immortalization of CD34⁺ cells derived from human umbilical cord blood." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43572145.

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Leung, Man Ching. "Identification of human hair follicle antigens targeted in the presumptive autoimmune hair follicle disorder Alopecia Areata and their potential functional relevance In Vitro. Methods development for isolation and identification of Alopecia Areata-relevant human hair follicle antigens using a proteomics approach and their functional assessment using an Ex Vivo hair follicle organ culture model." Thesis, University of Bradford, 2008. http://hdl.handle.net/10454/4330.

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Alopecia areata (AA) is a putative autoimmune hair loss disorder. It mainly affects the scalp hair but can also involve body hair, and can also affect the nail and the eye. While there are may be several lines of evidence to support the autoimmune basis of AA, there is still very little information on the hair follicle autoantigen(s) involved in its pathogenesis. In this project, serum antibodies (AA=10, control=10) were used to immunoprecipitate AA-relevant target antigens from normal human scalp hair follicle extracts. These immunoprecipitates were analysed by LC-MALDI-TOF/TOF mass spectrometry for target protein identification. This part of the project involved substantial methods development. Trichohyalin was immunoprecipitated by all AA sera, but by only 5 normal sera. Importantly, the mean Mascot scores of the AA group was significantly higher than the normal group (p=0.005). Keratin 16 was also identified from immunoprecipitates as another potential AA-relevant target antigen. Functional studies by ex vivo whole hair follicle organ culture using commercial antibodies to trichohyalin and keratin 16 significantly inhibited hair fibre elongation compared to controls. Indirect immunofluorescence studies revealed that AA sera contained higher immunoreactivity against normal human scalp anagen hair follicles compared to normal sera. Immunoreactivities were mainly in the outer root sheath and inner root sheath, and less so to the medulla and hair bulb matrix. Double immunofluorescence studies of AA and normal serum with anti-trichohyalin antibody (AE15) revealed co-localisation of 9 of the AA sera antibodies with trichohyalin in the inner root sheath (mostly in Henle's, less in Huxley's/inner root sheath cuticle), but only weakly in 3 normal sera. This study supports the involvement of an antibody response to anagen-specific hair follicles antigens in AA. Moreover, there may be some evidence that these antibodies may have a pathogenic role.
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Souri, M. "The effect of sulphur-containing amino acids on growth performance and hair production in vivo and in vitro by Angora and Cashmere goats." Thesis, University of Aberdeen, 1997. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU530016.

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Major conclusions of each experiment are as follows:- Experiment 1: • Under experimental conditions described in Chapter 3 Cashmere and Angora goats, on average, exhibited similar values for LWG. • Differences between two genotypes were noted in superior values of apparent digestibility of DM and CP although there were lower values of nitrogen retention in Cashmere than Angora goats; this result suggested that nitrogen utilisation was more efficient in the Angora goats. • In response to dietary rumen-protected methionine, nitrogen retention and LWG were improved in both genotypes. However total fibre yield and diameter were increased only in the Angora goats. Experiment 2: • The supply of rumen-protected methionine increased the total weight and protein and water concentration of carcass and non-carcass components of Angora goats. • Methionine supply had no effect on the proportion of dietary nitrogen partitioned between mohair and other body components. • Dietary methionine supplementation changed the amino acid composition of mohair (increased cyst(e)ine and reduced phenylalanine) and muscle samples (increased methionine, phenylalanine and lysine) in addition to producing increases in total weight of mohair and LWG. Experiment 3: • The presence of both methionine and cyst(e)ine was required to support maximum growth of isolated anagen mohair and cashmere secondary hair follicles <I>in vitro</I>. • The presence of methionine, but not cyst(e)ine when methionine was present, was essential for maintaining growth and viability of isolated hair follicles of Angora and Cashmere goats. Experiment 4: • Epidermal growth factor (EGF) at low concentration (1 μg/l) increased DNA concentration, protein deposition and elongation in anagen mohair secondary hair follicles. • At high concentration (10 μg/l) EGF produced a club-hair like structure which was associated with stimulation of cell proliferation in outer root sheath and inhibition in matrix cells. These changes resembled those occurring in anagen to catagen transition.
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Xie, Yan. "Ex vivo investigation of novel wound healing therapies and development of a 3-D human skin equivalent wound model." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/26541/1/Yan_Xie_Thesis.pdf.

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It has previously been found that complexes comprised of vitronectin and growth factors (VN:GF) enhance keratinocyte protein synthesis and migration. More specifically, these complexes have been shown to significantly enhance the migration of dermal keratinocytes derived from human skin. In view of this, it was thought that these complexes may hold potential as a novel therapy for healing chronic wounds. However, there was no evidence indicating that the VN:GF complexes would retain their effect on keratinocytes in the presence of chronic wound fluid. The studies in this thesis demonstrate for the first time that the VN:GF complexes not only stimulate proliferation and migration of keratinocytes, but also these effects are maintained in the presence of chronic wound fluid in a 2-dimensional (2-D) cell culture model. Whilst the 2-D culture system provided insights into how the cells might respond to the VN:GF complexes, this investigative approach is not ideal as skin is a 3-dimensional (3-D) tissue. In view of this, a 3-D human skin equivalent (HSE) model, which reflects more closely the in vivo environment, was used to test the VN:GF complexes on epidermopoiesis. These studies revealed that the VN:GF complexes enable keratinocytes to migrate, proliferate and differentiate on a de-epidermalised dermis (DED), ultimately forming a fully stratified epidermis. In addition, fibroblasts were seeded on DED and shown to migrate into the DED in the presence of the VN:GF complexes and hyaluronic acid, another important biological factor in the wound healing cascade. This HSE model was then further developed to enable studies examining the potential of the VN:GF complexes in epidermal wound healing. Specifically, a reproducible partial-thickness HSE wound model was created in fully-defined media and monitored as it healed. In this situation, the VN:GF complexes were shown to significantly enhance keratinocyte migration and proliferation, as well as differentiation. This model was also subsequently utilized to assess the wound healing potential of a synthetic fibrin-like gel that had previously been demonstrated to bind growth factors. Of note, keratinocyte re-epitheliasation was shown to be markedly improved in the presence of this 3-D matrix, highlighting its future potential for use as a delivery vehicle for the VN:GF complexes. Furthermore, this synthetic fibrin-like gel was injected into a 4 mm diameter full-thickness wound created in the HSE, both keratinocytes and fibroblasts were shown to migrate into this gel, as revealed by immunofluorescence. Interestingly, keratinocyte migration into this matrix was found to be dependent upon the presence of the fibroblasts. Taken together, these data indicate that reproducible wounds, as created in the HSEs, provide a relevant ex vivo tool to assess potential wound healing therapies. Moreover, the models will decrease our reliance on animals for scientific experimentation. Additionally, it is clear that these models will significantly assist in the development of novel treatments, such as the VN:GF complexes and the synthetic fibrin-like gel described herein, ultimately facilitating their clinical trial in the treatment of chronic wounds.
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Xie, Yan. "Ex vivo investigation of novel wound healing therapies and development of a 3-D human skin equivalent wound model." Queensland University of Technology, 2008. http://eprints.qut.edu.au/26541/.

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It has previously been found that complexes comprised of vitronectin and growth factors (VN:GF) enhance keratinocyte protein synthesis and migration. More specifically, these complexes have been shown to significantly enhance the migration of dermal keratinocytes derived from human skin. In view of this, it was thought that these complexes may hold potential as a novel therapy for healing chronic wounds. However, there was no evidence indicating that the VN:GF complexes would retain their effect on keratinocytes in the presence of chronic wound fluid. The studies in this thesis demonstrate for the first time that the VN:GF complexes not only stimulate proliferation and migration of keratinocytes, but also these effects are maintained in the presence of chronic wound fluid in a 2-dimensional (2-D) cell culture model. Whilst the 2-D culture system provided insights into how the cells might respond to the VN:GF complexes, this investigative approach is not ideal as skin is a 3-dimensional (3-D) tissue. In view of this, a 3-D human skin equivalent (HSE) model, which reflects more closely the in vivo environment, was used to test the VN:GF complexes on epidermopoiesis. These studies revealed that the VN:GF complexes enable keratinocytes to migrate, proliferate and differentiate on a de-epidermalised dermis (DED), ultimately forming a fully stratified epidermis. In addition, fibroblasts were seeded on DED and shown to migrate into the DED in the presence of the VN:GF complexes and hyaluronic acid, another important biological factor in the wound healing cascade. This HSE model was then further developed to enable studies examining the potential of the VN:GF complexes in epidermal wound healing. Specifically, a reproducible partial-thickness HSE wound model was created in fully-defined media and monitored as it healed. In this situation, the VN:GF complexes were shown to significantly enhance keratinocyte migration and proliferation, as well as differentiation. This model was also subsequently utilized to assess the wound healing potential of a synthetic fibrin-like gel that had previously been demonstrated to bind growth factors. Of note, keratinocyte re-epitheliasation was shown to be markedly improved in the presence of this 3-D matrix, highlighting its future potential for use as a delivery vehicle for the VN:GF complexes. Furthermore, this synthetic fibrin-like gel was injected into a 4 mm diameter full-thickness wound created in the HSE, both keratinocytes and fibroblasts were shown to migrate into this gel, as revealed by immunofluorescence. Interestingly, keratinocyte migration into this matrix was found to be dependent upon the presence of the fibroblasts. Taken together, these data indicate that reproducible wounds, as created in the HSEs, provide a relevant ex vivo tool to assess potential wound healing therapies. Moreover, the models will decrease our reliance on animals for scientific experimentation. Additionally, it is clear that these models will significantly assist in the development of novel treatments, such as the VN:GF complexes and the synthetic fibrin-like gel described herein, ultimately facilitating their clinical trial in the treatment of chronic wounds.
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Berton, Alix. "Conceptualisation d'un lipopeptide bifonctionnel inhibiteur des metalloproteinases matricielles et activateur du tgf beta-1 latent : determination de son efficacite in vitro et ex vivo (doctorat : biochimie - biologie moleculaire)." Reims, 2000. http://www.theses.fr/2000REIMM214.

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TRETOLA, MARCO. "FORMER FOODSTUFFS PRODUCTS INTENDED FOR PIG NUTRITION: IN VITRO AND IN VIVO NUTRITIONAL EVALUATION, IMPACT ON GROWTH PERFORMANCES AND GUT HEALTH." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/609808.

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La produzione animale riveste un ruolo chiave nel garantire la sicurezza alimentare. Tale ruolo viene esercitato soprattutto grazie all’approvvigionamento di prodotti di origine animale e prodotti dell’agricoltura. Tuttavia, a causa delle diminuite disponibilità di terreni destinati all’allevamento ed alla agricoltura, insieme ai cambiamenti climatici e alla riduzione delle risorse idriche, diventa sempre più importante aumentare la sostenibilità e l’efficienza del settore agroalimentare. Per fare ciò, diventa necessario soddisfare le crescenti esigenze utilizzando al tempo stesso una quantità ridotta di risorse. Questa tesi ha avuto come tema principale quello di esaminare a fondo il potenziale utilizzo di scarti della industria alimentare (chiamati “former foodstuffs products”, FFPs) come ingredienti alternativi e sostenibili per la nutrizione animale. I prodotti esaminati sono alimenti che vengono scartati dalla grande distribuzione per difetti relativi alla loro forma, al loro colore, al loro packaging ecc. Tali scarti solitamente sono destinati a diventare rifiuto, nonostante il loro elevato potenziale nel poter essere utilizzati come ingredienti sostenibili per mangimi. La prima parte della tesi si concentra sull’analisi della composizione chimica di sei diversi tipi di FFPs. Inoltre, di questi prodotti sono state anche stimate l’energia digeribile e metabolizzabile con riferimento ai suini, la digeribilità in vitro, l’indice glicemico e di idrolisi attraverso tecniche di digestione enzimatica. La seconda parte della tesi è stata dedicata agli aspetti legati alla sicurezza dei FFPs. Campioni di FFPs sono stati quindi analizzati per la loro carica microbica e la presenza di residui di materiale di imballaggio. Per questo ultimo aspetto, sono stati testati due metodi differenti: il primo, precedentemente validato, basato sull’uso dello stereomicroscopio; il secondo, basato sull’uso dello stereomicroscopio accoppiato ad un sistema digitale di acquisizione di immagine (Computer Vision System). L’ultima parte, invece, ha investigato gli effetti di una dieta in cui in cui i cereali comunemente utilizzati per la formulazione di diete per suini in post svezzamento, sono stati parzialmente sostituiti dagli FFPs. In particolare, una dieta di controllo e quella contenente FFPs sono state confrontate per quanto riguarda la digeribilità in vitro ed in vivo della sostanza secca, le performances di crescita di suini in post svezzamento, così come alcuni metaboliti ematici ed il microbiota fecale. I risultati della tesi hanno dimostrato che gli FFPs possono essere considerati una “versione fortificata” dei cereali tradizionali comunemente utilizzati nel settore suinicolo, con valori di digeribilità in vitro comparabili agli stessi, ma con valori di indice glicemico e di idrolisi maggiori, caratterizzandoli come una fonte eccellente di carboidrati. Tutti i campioni di FFP sono risultati sicuri dal punto di vista microbiologico e sempre privi di Salmonella. Per quanto concerne la presenza di residui di materiale da imballaggio, il livello di contaminazione è risultata sempre al di sotto delle soglie di tolleranza. Il Computer Vision System si è inoltre rivelato essere una rapida alternativa per rilevare la presenza di materiali di imballaggio nei FFPs se accoppiata allo seteromicroscopio. Lo studio in vivo ha rivelato che sia i valori di digeribilità in vitro che in vivo delle diete contenenti FFPs sono maggiori rispetto ai valori delle diete di controllo. Alla fine dell’esperimento, non sono state osservate differenze nelle performance di crescita, tuttavia nei suinetti alimentati con la dieta FFP c’è stato un aumento di glucosio plasmatico ed una riduzione nella concentrazione di urea. Il sequenziamento di nuova generazione delle regioni variabili V3 e V4 del gene che codifica per il 16S rRNA hanno evidenziato come l’utilizzo di FFPs nelle diete per suini in post svezzamento riduca sia la numerosità che la biodiversità dei batteri che costituiscono il microbiota nel largo intestino. L’analisi “unweighted beta diversity” ha anche dimostrato piccole differenze nella composizione dei taxa batterici tra il gruppo FFP e quello di controllo. Inoltre, l’analisi lineare delle discriminanti ha documentato un aumento del phylum Proteobacteria ed una diminuzione del genere Lactobacillales nel gruppo FFP rispetto al controllo. Questi risultati hanno messo in evidenza il potenziale di questi ingredienti alternativi ed il loro utilizzo sicuro nella nutrizione suinicola. Il loro aumentato utilizzo potrebbe quindi portare ad una riduzione dello spreco alimentare, una riduzione dei costi del mangime, e ad un ridotto impatto ambientale della catena alimentare.<br>Livestock play a key role in food security, through food provision, agricultural production, and by providing employment and income. However, with the diminishing availability of farmland, climate change and the threat of declining water resources, the goal is to meet the growing demand for food and feed by using fewer resources. Exploiting alternative ingredients for livestock, feed could be one way of increasing livestock sustainability. This thesis focused on processed and ready-to-eat food products that are no longer suitable for human consumption due to logistical, manufacturing or packaging defects. Such products would normally go to a landfill yet actually have a high potential of being used as sustainable feed ingredients. The first part of this thesis investigated the chemical composition of six different former foodstuff products (FFPs). Based on the FFP composition data, the digestible energy and metabolisable energy values for pigs were estimated. In addition, the in vitro digestibility values of FFPs were evaluated using a multi-step enzymatic technique. The in vitro predicted glycaemic index and hydrolysis index of the same samples were examined using a two-step in vitro digestion assay. In the second part, the safety issues linked to the use of FFPs were investigated. FFP samples were thus analysed in relation to the microbial load and the presence of presumed remnants of packaging materials. For this purpose, two different methods were used: stereomicroscopy, according to published methods; and stereomicroscopy coupled with a computer vision system. The final part addressed the effects of a diet in which common cereal grains were partially replaced by FFPs in post weaning piglet diets. Specifically, pig growth performance and selected plasma biochemical variables were evaluated in twelve post-weaning piglets. The apparent total tract digestibility of dry matter and the faecal microbiota were also characterized. When compared with common cereal grains used in pig feed formulations, FFPs can be considered a fortified version of cereals, with comparable in vitro digestibility values and with higher glycaemic and hydrolysis indexes, thus characterizing them as an excellent source of carbohydrates. All FFP samples were safe from a microbiological point of view, showing a limited microbial load and were always Salmonella free. Regarding the presumed remnants of packaging materials, the contamination level was always below the safety threshold set by German authorities, and the validated method demonstrated that packaging remnants were mainly from the 1-mm sieve mesh fraction. In order to find a more rapid and objective method for evaluating the packaging remnants, the innovative computer vision system was a rapid alternative for the detection of packaging remnants in ex-food samples when combined with a stereomicroscope. The in vivo study revealed that both in vitro and in vivo digestibility values were higher for the diet based on FFPs compared to the control diet. At the end of the experiment, no differences in growth performance were observed, however the plasma glucose increased in piglets fed FFPs compared to piglets fed the control diet, while the urea concentration decreased. The sequencing analysis of the variable regions V3 and V4 of the 16S rRNA gene showed that the use of FFPs in the post-weaning period decreased the bacterial richness and evenness in the large intestine. The unweighted beta diversity analysis also resulted in a statistically significant difference between the two groups in terms of the taxa composition. The linear discriminant analysis of effect size also demonstrated an increased amount of Proteobacteria phylum and a decreased amount of Lactobacillales genus in the FFP compared to the control group. The results highlighted the potential of these alternative feed ingredients and their safe use in pig nutrition. This is essential for establishing the best scientific practices for the use of FFPs in animal nutrition and feeding. Given the increasing need to obtain a more sustainable livestock sector, research in animal sciences should focus not only on increasing the efficiency of the animal production chain but also on the efficiency of the entire food system in ensuring sustainable nutrition. By recognizing that former foodstuffs that are not suitable for human consumption are a resource for animal nutrition and not a waste product, food and feed industries could reduce the amount of waste sent to landfill or deposed-off every year, thus saving costs, and reducing the environmental impact of the food production chain.
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Books on the topic "Ex vivo hair growth"

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Schreuder, Michiel F. Normal variation in nephron numbers. Edited by Adrian Woolf. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0349.

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Kidney development includes the formation of nephrons, which ceases around the 36th week of gestation. At that time, around 900,000 nephrons are formed, but with a 10-fold variation (from 200,000 to over 2 million). Many factors have been described to influence the number of nephrons per individual, such as genetic variations, intrauterine growth and prematurity, maternal diseases and (nutritional) deficiencies, and drugs used during nephrogenesis. Counting nephrons is currently only possible ex vivo, even though magnetic resonance imaging techniques are getting to the stage that in vivo estimations using stereology (the gold standard methodology) can be expected to become available in the next decade. In the meantime, renal size is often used as a marker for nephron endowment.
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Book chapters on the topic "Ex vivo hair growth"

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Edelkamp, Janin, Jennifer Gherardini, and Marta Bertolini. "Methods to Study Human Hair Follicle Growth Ex Vivo: Human Microdissected Hair Follicle and Human Full Thickness Skin Organ Culture." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0648-3_9.

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Calvo-Sánchez, María I., Sandra Fernández-Martos, and Jesús Espada. "A Photodynamic Tool to Promote a Sustained, ROS-Dependent Growth of Human Hair Follicles in Ex Vivo Culture." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0896-8_4.

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Bertolini, Marta, Ilaria Piccini, and Kevin J. McElwee. "In Vitro and Ex Vivo Hair Follicle Models to Explore Therapeutic Options for Hair Regeneration." In Stem Cell Biology and Regenerative Medicine. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98331-4_8.

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Muylle, L. "Ex Vivo Cytokine Production in Blood Components: Relevant or Irrelevant." In Cytokines and Growth Factors in Blood Transfusion. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4613-1137-9_6.

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Haensel, Daniel, Melissa A. McNeil, and Xing Dai. "Ex Vivo Imaging and Genetic Manipulation of Mouse Hair Follicle Bulge Stem Cells." In Skin Stem Cells. Springer New York, 2018. http://dx.doi.org/10.1007/7651_2018_136.

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Henschler, R., D. Möbest, F. Rosenthal, and R. Mertelsmann. "Ex Vivo Culture and Expansion of Haematopoietic Progenitor Cells in Cancer Patients." In Cytokines and Growth Factors in Blood Transfusion. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4613-1137-9_9.

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Tobin, Desmond J. "Ex Vivo Organ Culture of Human Hair Follicles: A Model Epithelial–Neuroectodermal–Mesenchymal Interaction System." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-984-0_14.

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Fehrholz, Markus, and Marta Bertolini. "Collapse and Restoration of Hair Follicle Immune Privilege Ex Vivo: A Model for Alopecia Areata." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0648-3_11.

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Piccini, Ilaria, and Marta Bertolini. "Experimentally Induced Epithelial–Mesenchymal Transition of Human Hair as a Model of Scarring Ex Vivo." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0648-3_12.

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Aglietta, M., L. Garetto, F. Sanavio, et al. "Role of Hematopoietic Growth Factors on the ex Vivo Expansion of Primitive Cord Blood Stem Cells." In Molecular Biology of Hematopoiesis 6. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4797-6_5.

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Conference papers on the topic "Ex vivo hair growth"

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Gee, A. P. "Hematopoietic Stem Cell Engineering: The Magic Bullet of the Next Millenium?" In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-1317.

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Abstract Hematopoietic stem cell [HSC] therapy has its origins as hematological rescue following marrow ablative high-dose therapy for refractory cancers and myelodysplastic syndromes. In its simplest form, bone marrow is collected from a tissue-matched related normal donor and intravenously infused into the patient who has usually received high-dose chemo/radiotherapy for his or her disease. The stem cells migrate to the marrow spaces, where they multiply and differentiate to restore blood cell-forming activity and immune defenses in the recipient Restrictions in the availability of tissue-matched marrow donors have prompted investigations into new sources of stem cells. These include use of the autologous marrow, which is collected from the patient and cryopreserved prior to therapy. The risk of tumor contamination in these grafts has resulted in the development of numerous methods to purge cancer cells from marrow ex vivo, or to enrich stem cells from the graft. This provided one of the earliest clinical applications for monoclonal antibodies and immunomagnetic cell separation. Another approach has been to use tissue-matched unrelated volunteer marrow donors, or grafts from mismatched family members. In both cases, ex vivo removal of T lymphocytes from the graft is advisable to prevent these cells initiating a severe or fatal reaction in the recipient - graft-versus-host disease. Recent studies have shown that recombinant human growth factors can be used to stimulate migration of HSC from the marrow into the blood, from which they are collected by automated cell separators, obviating the need for harvesting marrow under general anesthesia. The same growth factors have been used to expand and differentiate HSC ex vivo, with the hope that clinical grafts could ultimately be grown in the laboratory from a few milliliters of blood or marrow. Transplants have also been performed using placental/umbilical cord blood as the HSC source, and there are some indications that these cells may be more suitable for mismatched transplants. Genetic manipulation of stem cells can be used to correct a number of inherited diseases, and ultimately may allow specific beneficial properties to be introduced into blood-derived cells e.g. drug resistance into stem cells - to allow higher doses of chemotherapy to be used without destroying the bone marrow. The rapid expansion in this field of medicine, combined with advances in molecular and cellular biology offer the promise of stem cell engineering as an effective therapy in a variety of diseases.
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Nair, Praveen, Dileep Nair, Kaede Hinata, et al. "Abstract 5767: Ex vivo three-dimensional tumor growth assay: 3DX-TGA." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5767.

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Hananel, Arik, John W. Snell, Neal F. Kassell, and Matthew D. C. Eames. "Effects of human hair on trans-cranial focused ultrasound efficacy in an ex-vivo cadaver model." In 12TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. AIP, 2012. http://dx.doi.org/10.1063/1.4769943.

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Kubo, Toshio, Kadoaki Ohashi, Masahiro Osawa, et al. "Abstract 3681: Vascular endothelial growth factor receptor tyrosine kinase inhibitor inhibited mutated epidermal growth factor receptor-driven tumors ex vivo and in vivo." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3681.

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Munyonho, F. T., and J. K. Kolls. "Precision Cut Lung Slices (PCLS) as an Ex Vivo Model to Study Pneumocystis Murina Survival/Growth." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3859.

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Beneke, Valerie, Sven Cleeves, Hannah Kiefer, et al. "Acetate inhibits Pseudomonas aeruginosa growth and reduces inflammatory responses to infection in primary human lung tissue ex vivo." In ERS Congress 2024 abstracts. European Respiratory Society, 2024. http://dx.doi.org/10.1183/13993003.congress-2024.pa2393.

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Utter, Brent, Diann Brei, Jonathan Luntz, Daniel Teitelbaum, Manabu Okawada, and Eiichi Miyasaka. "Preliminary In Vivo Experimental Validation of SMA Based Bowel Extender for Short Bowel Syndrome." In ASME 2009 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2009. http://dx.doi.org/10.1115/smasis2009-1458.

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Short Bowel Syndrome is a serious medical condition caused by insufficient small bowel length resulting in significantly high rates of morbidity and mortality. The limited success of current therapies has prompted the investigation of a new treatment approach based on mechanotransduction — the process through which mechanical tensile loading on the bowel induces longitudinal growth. To enable clinically relevant mechanotransduction growth studies in large animals, such as pigs, a fully implantable and instrumented bowel extender device based on a Shape Memory Alloy (SMA) ratchet was developed and validated in benchtop and ex vivo tests. These devices, however, must also be validated against the unique in vivo environment which presents challenges such as sealing, battery life, surgical implantation, signal attenuation from tissue, and isolating the measurement of tensile loading on the bowel wall. This paper extends the earlier development work to in vivo validation experiments within live pigs. A brief summary of the bowel extender architecture and operation is provided along with earlier ex vivo results that established device limits for in vivo testing. The wireless communication rate was updated to extend battery life and new surgical implantation procedures and lengthening schemes were developed. Two bowel extenders were tested in in vivo experiments ranging from 2.5 to 4.5 days with data collected to validate the wireless communication, SMA ratcheting and load/displacement measurements, confirming that the bowel extender successfully operates in vivo. More importantly, the bowel extenders successfully induced significant growth, which is promising for future studies comparing different lengthening schemes for optimal growth and the development of a clinical device for treating short bowel syndrome in humans.
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Kozlov, D. S., S. A. Rodimova, D. P. Krylov, A. M. Mozherov, M. V. Zyuzin, and D. S. Kuznetsova. "ANALYSIS OF THE EFFICIENCY OF MIRNA DELIVERY USING NANOPARTICLES IN EX VIVO TISSUE SLICES OF THE LIVER." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-333.

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The study is aimed at selecting the optimal carrier for miRNA delivery. In the course of the study, miRNAs targeting insulin-like growth factor 1 were selected. The distribution and cytotoxicity of several types of nanoparticles were analyzed using a model of liver tissue explants and multiphoton microscopy. The efficiency of suppression of IGF1 expression was assessed using stem-loop PCR, RT-PCR and ELISA.
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Zhang, Xin, Erika Gonzalez, Carola Voss, and Anne Hilgendorff. "Late Breaking Abstract - ERBB3 involved in growth factor pathway crosstalk during neonatal lung development in a 3D ex vivo model." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.oa1619.

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Kute, Stephanie M., and David A. Vorp. "Regional Association of Biological and Hemodynamic Parameters in Distal End-to-Side Vascular Anastomoses Perfused Ex Vivo." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32513.

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Vascular bypass graft failure is a significant clinical problem and is frequently due to the formation of intimal hyperplasia (IH) [1–3]. IH is characterized by the accumulation of smooth muscle cells (SMC) and extracellular matrix in the intima of the vessel, which occurs when the normal balance between vascular cell proliferation and apoptosis (regulated cell death) is altered [4]. The disturbed flow present at the anastomosis has been implicated in the formation of IH and the link between hemodynamics and graft failure is via a complex cascade of events whereby biomechanical forces cause biological responses [5, 6]. For example, immediate early genes (IEG) such as c-fos, c-jun and egr-1 are involved in the signaling pathways for proliferation and apoptosis. When extracellular biomechanical stimuli (e.g. shear stress) cause the expression of IEG, their protein products translocate to the nucleus. These proteins regulate the expression of a number of genes implicated in cardiovascular disease including growth factors, adhesion molecules, proapoptotic substrates and coagulation factors [7–9]. Because IEG are involved in both proliferation and apoptosis, their expression may upset the normal balance between cell proliferation and apoptosis and could play a vital role in the IH formation in vascular bypass grafts.
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Reports on the topic "Ex vivo hair growth"

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Identification of Hazards in Meat Products Manufactured From Cultured Animal Cells. Food Standards Agency, 2023. http://dx.doi.org/10.46756/sci.fsa.crw572.

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Culturing of animal cells was developed in the late 19th and early 20th century, when researchers worked out how to support the growth of cells in media in an ex-vivo environment(footnote). The technology has been used commercially in the medical products industry, notably to produce antibodies for use as new medicines and as reagents in diagnostics. Animal cell culturing has expanded into the food industry especially due to its benefit in promoting sustainability for example by freeing up global arable land used for livestock farming, with cultured meat predicted to enter the UK market in the coming year(s) and already on the market in Singapore. With this in sight, a systematic search protocol was devised to identify hazardous concerns that will help inform the risk assessment for any future applications for authorisation to the FSA. To note, the term ‘cultured’ is now referred to as ‘cultivated’ but the report uses the former term to keep in line with the search string used for the research. This report was limited to meat products manufactured from cultured animal cells. Even though majority of these hazards cross-over to other products such as fish, there is potential to evaluate hazards associated with fish/seafood products separately in the near future. This hazard identification considers the nature of potential hazards associated with the production of cultured animal cells; a novel technology that uses animal cells and cell culturing to produce a substance that resembles meat thus avoiding animal rearing for meat products or aquaculture. As cultured animal cells may pose new risks this report aims to ‘scope out’ the technology to gain an understanding of it and to identify the potential risks that this may pose
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