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1

Cazzola, Mario. Acute exacerbations in COPD. Oxford: Clinical Pub., 2009.

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2

Schmidt-Weber, Carsten B., ed. Allergy Prevention and Exacerbation. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-69968-4.

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3

Acute exacerbation of respiratory diseases. New Delhi: Jaypee Brothers Medical Publishers, 2012.

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4

Allegra, Luigi, and Francesco Blasi, eds. Mechanisms and Management of COPD Exacerbations. Milano: Springer Milan, 2000. http://dx.doi.org/10.1007/978-88-470-2115-0.

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5

Ning, Qin, ed. Acute Exacerbation of Chronic Hepatitis B. Dordrecht: Springer Netherlands, 2019. http://dx.doi.org/10.1007/978-94-024-1603-9.

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6

Ning, Qin, ed. Acute Exacerbation of Chronic Hepatitis B. Dordrecht: Springer Netherlands, 2019. http://dx.doi.org/10.1007/978-94-024-1606-0.

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7

Barbara, Forey, ed. Exacerbation of asthma: Epidemiological evidence in children. New York: Nova Science, 2008.

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8

Luan, Xiujie. Study of the bacteria associated with exacerbation of late-onset asthma. [Derby: University of Derby], 2000.

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9

Dia, Mamadou. L' exacerbation de la crise: Au Sénégal, en Afrique, dans le monde. [Dakar]: Grenier du patriarche, 2004.

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10

Lehmann, Harold P. Practice parameter: The treatment of acute exacerbations of asthma in children : technical report. Elk Grove Village, IL: The Academy, 1994.

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11

Lee, Peter N. Exacerbation of asthma in children and exposure to environmental tobacco smoke: A detailed reivew of the epidemiological evidence. New York: Nova Science, 2009.

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12

Lee, Peter N. Exacerbation of asthma in children and exposure to environmental tobacco smoke: A detailed reivew of the epidemiological evidence. New York: Nova Science, 2009.

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13

Lee, Peter N. Exacerbation of asthma in children and exposure to environmental tobacco smoke: A detailed reivew of the epidemiological evidence. New York: Nova Science, 2009.

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14

Vrontamitis, Paul Nicholas. The exacerbation of the finance gap within small to medium-sized enterprise as the major obstacle to their development and the role and implications of formal and informal venture capital in solving this problem. Oxford: Oxford Brookes University, 1999.

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15

(Editor), Sebastian L. Johnston, and Paul O'Byrne (Editor), eds. Exacerbations of Asthma. Informa Healthcare, 2007.

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16

L, Johnston Sebastian, and O'Byrne Paul M. 1951-, eds. Exacerbations of asthma. Abingdon: Informa Healthcare, 2007.

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17

Gilchrist, Francis J., and Alex Horsley. Management of respiratory exacerbations. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198702948.003.0005.

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Cystic fibrosis lung disease is characterized by chronic infection, inflammation and a progressive loss of lung function. Patients are also affected by recurrent episodes of increased respiratory symptoms, called exacerbations which have a detrimental effect on quality of life, the rate of lung function decline, and mortality. Early diagnosis and treatment is vital. Diagnosis relies on a combination of symptoms, examination findings, the results of laboratory tests, and lung function. Antibiotics are the mainstay of treatment but airway clearance, nutrition, and glucose homeostasis must also be optimized. Mild exacerbations are usually treated with oral antibiotics and more severe exacerbations with intravenous antibiotics. The choice of antibiotic is guided by the patient’s chronic pulmonary infections, the in-vitro antibiotic sensitivities, known antibiotic allergies, and the previous response to treatment. In patients with chronic Pseudomonas aeruginosa infection, antibiotic monotherapy is thought to increase the risk of resistance and treatment with 2 antibiotics is therefore suggested (usually a β‎-lactam and an aminoglycoside). Although there is a lack of evidence on the duration of treatment, most patients receive around 14 days. This can be altered according to the time taken for symptoms and lung function to return to pre-exacerbation levels. If patients are carefully selected and receive appropriate monitoring, home intravenous antibiotics can be as effective as in-patient treatment. They are also associated with decreased disruption to patients / family life, decreased risk of cross infection and decreased costs.
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18

Wedzicha, Jadwiga A., and Fernando J. Martinez, eds. Chronic Obstructive Pulmonary Disease Exacerbations. CRC Press, 2008. http://dx.doi.org/10.3109/9781420070873.

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19

Burgel, Pierre-Régis, Marco Contoli, and José Luis López-Campos, eds. Acute Exacerbations of Pulmonary Diseases. European Respiratory Society, 2017. http://dx.doi.org/10.1183/2312508x.erm7717.

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20

Scadding, Alys. Terminal care in respiratory illness. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0146.

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The terminal phase is the period of time between living with a reasonable quality of life, and the process of dying. While lung cancer and pulmonary fibrosis have the potential to deteriorate rapidly, the majority of lung diseases worsen over years. Every exacerbation of the condition leads to a decline in both lung function and performance status, and often the pre-exacerbation level of functioning is never regained. There is not a defining point to indicate whether a patient is entering the terminal stages of their illness, but practice shows that the following signs are suggestive: increasing breathlessness and thus becoming increasingly housebound; increasing oxygen requirements; declining pulmonary function test results; increasingly frequent exacerbations requiring hospital admission and/or non-invasive ventilation; developing cor pulmonale; weight loss and difficulty maintaining weight; anxiety and depression; if the death of the patient within the next year would not be a surprise.
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21

Mechanisms and Management of COPD Exacerbations. Springer, 2012.

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22

Mechanisms and Management of COPD Exacerbations. Springer, 2000.

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23

Lynde, Grant C. Asthma and Pregnancy. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0054.

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Asthma’s progression during pregnancy is highly variable. Improvement in symptoms can be seen in 18%–34% of patients, while worsening of symptoms can be seen in 20%–42% of patients. Acute exacerbations of asthma are most frequently seen late in the second trimester and are associated with a viral upper-respiratory infection. An acute exacerbation of asthma in the parturient can result in increased risk of maternal mortality, preterm delivery, and low-birth-weight infants. In patients with moderate to severe asthma, good control with inhaled corticosteroids, such as budesonide, is a cornerstone of reducing morbidity and mortality. The four components of care for the asthmatic patient are education, control of environmental factors, medications, and monitoring of symptoms.
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24

Probst, Vanessa S. Rehabilitation in Copd Patients With Acute Exacerbations. Leuven University Press, 2005.

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25

Sj�bring, U., and J. D. Taylor, eds. Models of Exacerbations in Asthma and COPD. S. Karger AG, 2007. http://dx.doi.org/10.1159/isbn.978-3-8055-8173-8.

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26

M, Siafakas N., Anthonisen N. R, and Georgopoulos Dimitris, eds. Acute exacerbations of chronic obstructive pulmonary disease. New York: M. Dekker, 2004.

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27

Anzueto, A., and T. Schaberg. Clinician's Manual on Acute Exacerbations of Chronic Bronchitis. Science Press Inc., 2003.

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28

Sahn Steven, A. Clinical Focus Series: Acute Exacerbation of Respiratory Diseases. Jaypee Brothers Medical Publishers (P) Ltd., 2012. http://dx.doi.org/10.5005/jp/books/11683.

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29

Macagno, Francesco, and Massimo Antonelli. Therapeutic strategy in acute or chronic airflow limitation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0112.

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The fragility of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) accounts for their frequent hospitalization and their high intensive care unit risk. Therapy for AECOPD is varied and the need for hospitalization must be always carefully evaluated, considering the risk factors related to the presence of multi-resistant pathogens or the need of invasive procedures. The prolonged use of oxygen therapy requires an accurate monitoring of blood gases and continuous oximetry. Inhalation therapy can be performed using nebulizers, predosed aerosols or powders for inhalation. Corticosteroids for oral and systemic use now play an established role in AECOPD, because bacterial infections account for 50% of exacerbations. Non-invasive ventilation (NIV) must be considered the first option in AECOPD patients and acute respiratory failure if there are no contraindications. The careful monitoring of the patient and the response to NIV are indispensable elements for therapeutic success.
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30

Models of Exacerbations in Asthma and COPD (Contributions to Microbiology). S. Karger AG (Switzerland), 2007.

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31

Self management of asthma exacerbations: An analysis of the decision process. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1993.

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32

(Editor), Wisia Wedzicha, and Fernando J. Martinez (Editor), eds. Chronic Obstructive Pulmonary Disease Exacerbations (Lung Biology in Health and Disease). Informa Healthcare, 2008.

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33

Ning, Qin. Acute Exacerbation of Chronic Hepatitis B: Volume 2. Diagnosis and Management. Springer, 2019.

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34

Aap and National Heart. New Parameter: The Office Management of Acute Exacerbations of Asthma in Children. American Academy of Pediatrics, 1994.

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35

(Editor), Nikos Siafakas, Nicholas R. Anthonisen (Editor), and Dimitris Georgopoulos (Editor), eds. Acute Exacerbations of Chronic Obstructive Pulmonary Disease (Lung Biology in Health and Disease). Informa Healthcare, 2003.

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36

Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (Evidence report/technology assessment). Agency for Healthcare Research and Quality, 2001.

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37

Schmidt-Weber, Carsten B. Allergy Prevention and Exacerbation: The Paradox of Microbial Impact on the Immune System. Springer, 2019.

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38

Schmidt-Weber, Carsten B. Allergy Prevention and Exacerbation: The Paradox of Microbial Impact on the Immune System. Springer, 2018.

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39

The Role of Environmental Tobacco Smoke in Asthma Induction and Exacerbation in Children and Adults. Nova Science Pub Inc, 2007.

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40

Ning, Qin. Acute Exacerbation of Chronic Hepatitis B: Volume 1. Definition, Research Technology, Virology, Genetics and Immunology. Springer, 2019.

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41

Dahlen, Inger. Obstructive Pulmonary Disease: Studies of Acute Exacerbations and Immunologic Status (Comprehensive Summaries of Uppsala Dissertations, 870). Uppsala Universitet, 1999.

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42

Spruit, Martijn A. Effects of Exercise Training & Acute Exacerbations on Muscle Function in Patients With Chronic Obstructive Pulmonary Disease. Leuven Univ Pr, 2004.

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43

Bunker, Tim D. The clinical evaluation of the shoulder. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.004001.

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♦ History: onset event, radiation, exacerbation, night pain, functional deficit♦ Examination: active and passive movement, impingement signs, instability tests♦ Investigation: x-rays, ultrasound, CT and MR.
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44

O’Neal, M. Angela. Seizures Occurring Once a Month. Edited by Angela O’Neal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190609917.003.0005.

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In this chapter, the hormonal influences on epilepsy are discussed. Catamenial epilepsy is defined when seizure frequency increases correlated with certain phases of the menstrual cycle. The most common type as demonstrated by this patient is the perimenstrual exacerbation, C1. This corresponds to a progesterone decline. The next most common pattern is the periovulatory exacerbation, C2. This is characterized by an increase in seizure frequency associated with ovulation and the associated surge in estrogen. The luteal pattern, C3, is the least frequent. In this pattern, seizure frequency increases in the luteal phase of the menstrual cycle. An approach to treatment of catamenial epilepsy is reviewed.
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45

Guglielmi, Valeria, Judith Souget, Wouter van Elzelingen, Ingo Willuhn, and Nienke Vulink. Influence of Sex Hormones on OCD. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0027.

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OCD symptoms often seem to correlate with hormonal changes. For example, onset during puberty or in the postpartum period is common, and some female patients report monthly fluctuations in their symptoms. This chapter reviews available evidence about the interaction between the sex hormones estrogen, progesterone, and testosterone, and the neuropeptide oxytocin, and the initiation, amelioration, or exacerbation of OCD symptoms. Human studies as well as animal studies are reviewed. Furthermore, suggestions for clinical practice are provided, including: patient education, screening and treatment of perinatal OCD, cognitive behavioral therapy, and pharmacotherapy. The chapter concludes with suggestions on future research into the onset and exacerbation of OCD in women relative to reproductive cycle events.
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46

Wiffen, Philip, Marc Mitchell, Melanie Snelling, and Nicola Stoner. Therapy-related issues: respiratory system. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199603640.003.0018.

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Asthma management in adults: British Thoracic Society and SIGN guidelines 390Inhaler techniques 392• Minimize symptoms during the day and night.• Minimize need for reliever medication.• No exacerbations.• No limitation on physical activity.• Achieve best possible pulmonary function.•...
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47

Murray, E. Lee, and Karl E. Misulis. Neurologic Complications in Surgical Patients. Edited by Karl E. Misulis and E. Lee Murray. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190259419.003.0012.

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Neurologic complications in surgical patients can be directly related to surgery, indirectly related to hospitalization, or related to the exacerbation of underlying medical conditions. Presentation and differential diagnosis of some common complications are discussed.
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48

Carr, Sylvia Jocelyn. The effect of individualized pulmonary rehabilitation after moderate or severe exacerbation in individuals with chronic obstructive pulmonary disease. 2007.

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49

Lehmann, Harold P. Technical Report: Practice Parameter : The Treatment of Acute Exacerbations of Asthma in Children (Technical Report / American Academy of Pediatrics). American Academy of Pediatrics, 1994.

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50

Pitta, Fabio. Physical Activities in Daily Life in Patients With Copd: Characterization, Impact of Acute Exacerbations & Pulmonary Rehabilitation (Acta Biomedica Lovaniensia). Leuven University Press, 2005.

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