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1
Forde, James C., Jonathan L. Davila, Brian K. Marks, et al. "Urogynecological conditions associated with overactive bladder symptoms in women." Canadian Urological Association Journal 11, no. 3-4 (2017): 83. http://dx.doi.org/10.5489/cuaj.3962.
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Introduction: Overactive bladder symptoms (OAB) affect 9–43% of women and are associated with underlying disorders, including pelvic organ prolapse (POP) and stress urinary incontinence (SUI). The aim of this study is to identify urogynecological conditions associated with OAB symptoms.Methods: This prospective, institutional review board-approved study included women referred to a tertiary centre with lower urinary tract symptoms (LUTS). All women completed the selfadministered OAB questionnaire (OABSS). Those with an OABSS ≥8, the cutoff, were considered to have OAB symptoms. Patients underwent a history and physical examination (including Baden- Walker prolapse grading and stress test), 24-hour voiding diary, pad test (for urinary incontinence), urinalysis, and uroflow with post-void residual volume. Patients were classified clinically into the following: idiopathic OAB, SUI, POP, bladder outlet obstruction (BOO) neurogenic bladder (NGB), recurrent urinary tract infection (UTI), and miscellaneous.Results: In total, 148 women met the inclusion criteria with a mean age of 67 years. Only 27% had no comorbid conditions and were considered idiopathic OAB. Associated urogynecological conditions included SUI in 37%, POP in 26%, miscellaneous conditions in 18%, recurrent UTI in 11%, NGB in 9%, and BOO in 8%. Some patients met criteria for more than one category, thus the total is greater than 100%.Conclusions: In a tertiary care setting, a significant proportion of women with OAB symptoms have underlying conditions that may cause or contribute to their symptoms. Appropriate evaluation is desirable to enhance our understanding of the relationship of these conditions to the diagnosis, treatment, outcomes, and pathophysiology of OAB.
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Malanowska, Ewelina, Andrzej Starczewski, Włodzimierz Bielewicz, and Matteo Balzarro. "Assessment of Overactive Bladder after Laparoscopic Lateral Suspension for Pelvic Organ Prolapse." BioMed Research International 2019 (April 4, 2019): 1–6. http://dx.doi.org/10.1155/2019/9051963.
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Background. Pelvic organ prolapses (POP) and overactive bladder (OAB) may coexist and both negatively impact quality of life in women. The correlation between POP and OAB remains unclear, but these patients may have the OAB resolution after the surgical treatment of POP. Aim of our study was to assess the anatomical results and the effect on OAB symptoms in women who underwent laparoscopic lateral suspension for POP. Materials and Methods. This prospective study included all women with apical POP who underwent surgical repair with laparoscopic uterine lateral suspension from January 2016 to December 2017. The baseline and the 1-year follow-up included post-void residual measurement, urinalysis, vaginal examination, OAB symptoms evaluation, and administration of questionnaires (PFDI-20, UDI 6). Results. 64 women underwent laparoscopic lateral suspension for uterine prolapse and 78.1% had concomitant anterior vaginal wall defect. At 1-year follow-up the anatomic success rates were 84.4% for the apical and 76.2% for the anterior compartment. The comparison between OAB symptoms before and after the surgical procedure showed the resolution of OAB in 76% of the women, while de novo OAB was present in 2.6%. With the questionnaires 95.3% (61/64) of our patients were satisfied after the POP repair. We documented a trend in ameliorating of OAB regardless of the POP-Q stage. However, the Pearson test showed this correlation as statistically significant only in women with anterior vaginal wall defect stage III and apical stage II. No patient had vaginal exposure of the polypropylene mesh. Conclusion. Our data show how laparoscopic lateral suspension is an effective procedure for apical and anterior vaginal wall defects. This study provides further evidence for the concept that OAB in women with POP >II stage improves after a successful POP surgery. These women may benefit from a resolution of OAB and POP symptoms with the improvement of patient’s quality of life.
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Kosilov, Kirill V., Sergay A. Loparev, Marina A. Ivanovskaya, and Liliya V. Kosilova. "Caffeine as a Probable Factor for Increased Risk of OAB Development in Elderly People." Current Urology 9, no. 3 (2015): 124–31. http://dx.doi.org/10.1159/000442866.
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Objective: This study was conducted to compare overactive bladder (OAB) prevalence among people greater than 60 years of age who intake various doses of caffeine, as well as those who abstain from caffeine. Patients and Methods: A randomized observational study was carried out in Vladivostok Gerontological Hospital. A total of 1,098 retired people greater than 60 years of age (659 women and 439 men, average age 67.1 years) took part in the study. They were admitted to the in-patient department with the purpose of annual physical examination performed in accordance with the order of the Ministry of Public Health of the Russian Federation. People over age 60, who at the moment of examination were in satisfactory health condition, were included into the study. People in which OAB had been detected or who used to take antimuscarinic were excluded from the study. Assessment tools for examining the patients' lower urinary tract condition were as follows: OAB-q SF, urination diaries, and uroflowmetry. Results: In the course of the experiment conducted, we found that 1/3 of people, both men and women greater than 60 years of age, who did not previously seek medical advice due to urination troubles, had symptoms of detrusor overactivity. These symptoms were moderate and did not bother patients too much in most cases (63.4%). It was also found that most patients consumed no more than 300mg caffeine with beverages per day, with 30% and 10% of patients suffering from OAB or severe detrusor overactivity, respectively. At the same time, almost 50% of patients taking more than 300 mg of caffeine per day suffer from OAB. Conclusion: 48.1% of people over 60 years of age suffering from overactive detrusor symptoms consume greater than 300 mg caffeine daily, which is significantly higher than that of their peers who do not intake excessive amounts of caffeine.
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Bagińska, Joanna, Edyta Sadowska, and Agata Korzeniecka-Kozerska. "An Examination of the Relationship between Urinary Neurotrophin Concentrations and Transcutaneous Electrical Nerve Stimulation (TENS) Used in Pediatric Overactive Bladder Therapy." Journal of Clinical Medicine 10, no. 14 (2021): 3156. http://dx.doi.org/10.3390/jcm10143156.
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This article aims to explore changes in urinary concentrations of selected neurotrophins in the course of TENS therapy in children with overactive bladder (OAB). A two-group open-label prospective study was conducted. The intervention group comprised 30 children aged between 5 and 12 years old with OAB refractory to conservative therapy. They received 12 weeks of TENS therapy in a home setting. The urinary neurotrophins, NGF, BDNF, NT3, NT4, were measured by ELISA at baseline and at the end of the TENS therapy. Total urinary neurotrophins levels were standardized to mg of creatinine (Cr). We compared the results with the reference group of 30 participants with no symptoms of bladder overactivity. The results revealed that children with OAB both before and after TENS therapy had higher NGF, BDNF, and NT4 concentrations in total and after normalization to Cr than the reference group in contrast to NT3. The response to the therapy expressed as a decrease of urinary neurotrophins after TENS depended on the age and the presenting symptoms. In conclusion, children older than 8 years of age with complaints of daytime incontinence responded better to TENS.
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Ardiansyah, Edy, M. F. G. Siregar, R. A. Ganie, and I. B. Utra. "Controlled Clinical Trial Effect of Noni Fruit Extract (Morinda citrifolia) Toward Overactive Bladder Women through Observation of High-Sensitivity C-reactive Protein in Urine Levels." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 706–10. http://dx.doi.org/10.3889/oamjms.2020.4693.
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BACKGROUND: The prevalence of overactive bladder (OAB) appears to increase with age (aging), and free radicals most contribute to an increase in the aging process. But now, some researchers have found the efficacy of Morinda citrifolia in inhibiting the oxidative stress process so that it is expected to be beneficial for the treatment of OAB.
AIM: The aim of this study was to find out the effect of M. citrifolia extract on overactive women bladder (OAB) through observation of high-sensitivity C-reactive protein (hs-CRP) urine level.
METHODS: This research is an experimental study using double-blind randomized controlled trial design conducted at General Hospital H. Adam Malik Medan, USU Pharmacy Laboratory for extraction of noni fruit (M. citrifolia) and the Integrated Laboratory of Biochemical-Biomolecular USU Faculty of Medicine for the examination of hs-CRP urine levels. A t-dependent test is performed if data distribution is normally distributed or if not normally distributed, the median values are compared with the Mann–Whitney U-test. The effect of noni in hs-CRP levels performed by wilcoxon signed-Ranks Test. The statistical significance test with CI 95% and significant difference value p<0,05.
RESULTS: These results indicate that the noni fruit extract has weak antioxidant activity (IC50 >150 ppm). From the statistical analysis, a significant difference (p < 0.05) was obtained in hs-CRP urine level after compared to before treatment. These results indicate that after treatment, there was an improvement in the degree of OAB symptom scores in Group A and Group B.
CONCLUSIONS: Noni fruit extract (M. citrifolia) is proven to be able to inhibit oxidative stress in urothelium through observation of hs-CRP urine levels in overactive women bladder (OAB).
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Naumann, Gert, Thomas Hitschold, Dominique Frohnmeyer, Peter Majinge, and Rainer Lange. "Sexual Disorders in Women with Overactive Bladder and Urinary Stress Incontinence Compared to Controls: A Prospective Study." Geburtshilfe und Frauenheilkunde 81, no. 09 (2021): 1039–46. http://dx.doi.org/10.1055/a-1499-8392.
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Abstract Introduction and Hypothesis Female urinary incontinence (UI) has a negative impact on sexual function and sexual quality of life (QoL) in women. But there is still no consensus on the type of UI or the prevalence of sexual dysfunction (SD). The aim of the study was to evaluate sexual disorders in women with overactive bladder (OAB) compared to patients with urinary stress incontinence (SUI) and healthy controls. Materials and Methods 106 women presenting to a urogynecological outpatient clinic (referral clinic) were investigated using standardized questionnaires and the Female Sexual Function Index (FSFI-d). All 65 incontinent women underwent a full urodynamic examination; the controls (31) were non-incontinent women in the same age range who came for routine check-ups or minor disorders not involving micturition or pelvic floor function. Women with mixed urinary incontinence, a history of previous medical or surgical treatment for UI, recurrent urinary tract infections, previous radiation therapy or pelvic organ prolapse of more than stage 2 on the Pelvic Organ Prolapse Quantification (POP-Q) system were excluded. Results 100 questionnaires could be evaluated (94.3%). Thirty-four women had urinary stress incontinence, 35 had OAB, 31 were controls. Mean age was 56 years, with no significant differences between groups. The scores of the questionnaire ranged from 2 to 35.1 points. The median score of OAB patients was significantly lower (17.6) than the median score of the controls (26.5; p = 0,004). The stress-incontinent women had a score of 21.95, which was lower than that of the controls but statistically non-significant (p = 0.051). In all subdomains, the OAB patients had lower scores than the stress-incontinent women and significantly lower values than the control group. Most striking was the impairment of “sexual interest in the last 4 weeks”. The figure for “none or almost no sexual activity” was 80% for the OAB group, 64.7% for the group of stress-incontinent women and 48% for the control group. Incontinence during intercourse was reported by one OAB patient and 4 stress-incontinent women but did not occur in the control group. Conclusions There is a high prevalence of SD in women with urinary incontinence. Patients with OAB reported a greater negative impact on sexual function and had significantly lower scores for the FSFI questionnaire than patients with stress incontinence or controls.
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Shkodkin, S. V., M. V. Pokrovsky, S. S. Krasnyak, et al. "Treatment of overactive bladder symptoms in women with Diunorm®: preliminary results report." Vestnik Urologii 9, no. 2 (2021): 100–110. http://dx.doi.org/10.21886/2308-6424-2021-9-2-100-110.
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Introduction. Overactive bladder (OAB) with or without urgent incontinence tends to progress with age and occurs in both men and women. However, the frequency of occurrence in the female population averages about 25%.Purpose of the study. To assess the effectiveness and safety of the drug Diunorm® (in caps.) in the prevention and treatment of OAB in women.Materials and methods. The statistical analysis includes the results of a survey of 28 women with symptoms of OAB, whose average age was 35.3 years. The drug Diunorm® was used for treatment in dosage 400 mg QD for 90 days. Patients completed the Overactive Bladder Awareness Tool and a urination diary. Additionally, urinalysis, bacteriological examination of urine, uroflowmetry, bladder ultrasound and cystoscopy were performed.Results. All women throughout the study had negative urine cultures and no pyuria in urinalysis, which excluded an infectious etiology of urinary dysfunction. During therapy, a statistically significant decrease in irritative symptoms was recorded according to the Overactive Bladder Awareness Tool questionnaire. The sum of points after 1 and 3 mo decreased by 3.0 and 4.3 points, respectively (p < 0.05). Positive dynamics in terms of the points' sum was noted in 75%, in relation to nocturia in 82% of patients (p < 0.01). The average urination rate increased from 13.3 ± 0.7 ml/s to 15.1 ± 0.7 ml/s and 15.4 ± 0.5 ml/s after 1.5 and 3 months, respectively (p < 0,0001). A similar trend was observed for maximum urine flow and residual urine volume. The maximum urine flow when taking Diunorm® increased from 15.9 ± 0.6 ml/s to 17.4 ± 0.5 ml/s and 18.1 ± 0.4 ml/s (p < 0.001). Residual urine volume decreased throughout the study. When included in the study, after 1,5 and 3 mo, this indicator was 19.9 ± 1.4; 12.2 ± 1.6 and 6.4 ± 1.1 ml, respectively (p < 0.001).Conclusion. Diunorm® can become a worthy alternative to traditional first-line OAB therapy. Comparative studies are required to obtain a high-level evidence base.
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Gubbiotti, Marilena, Antonella Conte, Savino M. Di Stasi, Nicola Tambasco, and Antonella Giannantoni. "Feasibility of mirabegron in the treatment of overactive bladder in patients affected by Parkinson’s disease: A pilot study." Therapeutic Advances in Neurological Disorders 12 (January 2019): 175628641984345. http://dx.doi.org/10.1177/1756286419843458.
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Background: We investigated the effectiveness and safety of mirabegron oral treatment in a group of patients with Parkinson’s disease (PD) and overactive bladder (OAB), refractory to antimuscarinics. Materials and methods: Thirty patients with PD and refractory OAB were prospectively included in the study. At baseline, motor symptoms, severity of disease and cognitive status were assessed with the Hoehn–Yahr Scale, the Unified Parkinson’s disease Rating Scale, the Mini Mental State examination and the Montreal Cognitive Assessment. At baseline, urinary symptoms, satisfaction with treatment and the impact of urinary incontinence on quality of life (QoL) were assessed with the 3-day voiding diary, the Visual Analogue Scale (VAS), the Incontinence–QoL questionnaire and urodynamics. Patients started assuming mirabegron 50 mg tablets once daily. Evaluation of urinary symptoms and related questionnaires, motor symptoms, severity of PD and uroflowmetry with postvoid residual volume measurement were then repeated at the 3- and 6-month follow up. Side effects were also noted. Results: At baseline, the most frequently reported urinary symptoms were: urinary urgency (present in all the patients), urge urinary incontinence in 28/30 (93.3%) and increased daytime urinary frequency in 25 (83.3%) patients. At the 3-month follow up, 7 out of the 30 patients achieved a complete urinary continence. Significant improvements in VAS and Incontinence–QoL scores were observed in 24 patients. These benefits were maintained for the whole observation period. Four patients discontinued treatment due to poor efficacy, and two due to the cost of the drug. Conclusions: Mirabegron is a safe and effective treatment in patients with PD and OAB refractory to anticholinergics in the short-term follow up.
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Kupec, Tomas, Ulrich Pecks, Charlotte M. Gräf, Elmar Stickeler, Ivo Meinhold-Heerlein, and Laila Najjari. "Size Does Not Make the Difference: 3D/4D Transperineal Sonographic Measurements of the Female Urethra in the Assessment of Urinary Incontinence Subtypes." BioMed Research International 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/1810352.
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Purpose.The objective was to evaluate the usefulness of transperineal ultrasound in the assessment of the urethral length and urethral lumen by 3D/4D transperineal sonography to discriminate between female patients with subtypes of urinary incontinence.Methods.A total of 150 female patients underwent an examination because of urinary incontinence. 41 patients were diagnosed with urgency urinary incontinence (OAB), 67 patients were diagnosed with stress urinary incontinence (SUI), and 42 patients were in the control group (CTRL). Three diameters of the urethral lumen (proximal (U1), medial (U2), and distal (U3)) and the urethral length were measured. By the assessment of the urethral lumen, the presence of the urethral funneling was evaluated.Results.We found a significant difference in the urethral length and urethral lumen U2 of OAB and SUI versus CTRL. The urethral length was significantly greater (P<0.05) and the urethral lumen was significantly wider (P<0.05) in the patients with urinary incontinence. The incidence of the urethral funneling was significantly higher (P<0.05) in the study groups with urinary incontinence than in the control group.Conclusions.Our results have shown the urethral changes obtained by ultrasound in patients with urinary incontinence, but they are still insufficient to distinguish between subtypes of urinary incontinence.
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Chang, Che-Wei, Yung-Shun Juan, Yuan-Han Yang, and Hsiang-Ying Lee. "The Relationship Between Lower Urinary Tract Symptoms and Severity of Alzheimer’s Disease." American Journal of Alzheimer's Disease & Other Dementiasr 36 (January 1, 2021): 153331752199265. http://dx.doi.org/10.1177/1533317521992657.
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Introduction: Urinary incontinence (UI) is more prevalent in elderly populations with dementia than those without dementia. Alzheimer’s disease (AD) is the most common cause of dementia. Urge UI, the most common type of UI in AD patients, causes more morbidity and mortality. However, it is inconvenient to obtain the report of urodynamic study from AD patient to diagnose urinary incontinence. Nevertheless, it is easier to obtain subjective or objective questionnaires from the patients or the caregivers. The data collected from the questionnaires are used to evaluate if severity of dementia is associated with urge UI and other lower urinary tract symptoms (LUTs). Patients and Methods: A total of 43 AD patients were enrolled in this study, all of whom were checked post-void residual (PVR) urine amount by sonography after voiding. The severity of dementia was evaluated by questionnaire including Cognitive Abilities Screening Instrument (CASI), Mini Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), and Clinical Dementia Rating Sub-of-Box (CDR-SB). The LUTs were assessed with International Consultation of Incontinence Questionnaire (ICIQ) and Overactive bladder symptom scores (OABSS) questionnaire. Independent t test and Pearson’s correlation analysis were calculated. Results: The average age in both AD with/without urge UI patients is 78 years old. The scores of CDR-SB, OABSS and ICIQ are significantly different in these 2 groups (p = 0.023, p = 0.003, p = 0.001; respectively). However, the neurophysiological scores of CASI, MMSE, CDR, CDR-SB is not correlated with OABSS (r = 0.047, p = 0.382; r = 0.074, p = 0.317; r = 0.087, p = 0.288; r = 0.112, p = 0.237; respectively). Interestingly, if we separate each individual symptom of OAB, there is a significant correlation between CDR-SB and urge UI score (r = 0.314, p = 0.023). Conclusions: Higher lower urinary tract symptom scores are noted in AD patients with urge UI. The CDR-SB score is highly correlated with urge UI in AD patients.
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Luppold, William G. "Regional Examination of Red Oak Lumber Price Trends." Northern Journal of Applied Forestry 14, no. 4 (1997): 173–77. http://dx.doi.org/10.1093/njaf/14.4.173.
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Abstract Nearly 25% of the eastern sawtimber inventories are of species classified as red oak. Over the last 20 yr, red oak has become the most commonly used hardwood in the production of furniture, kitchen cabinets, and millwork. However, differences in subspecies and growing conditions produce variations in color and texture of red oak lumber produced from timber grown in Northern, Appalachian, and Southern regions. In the late 1980s, users of hardwood lumber began to pay higher prices for red oak lumber from the Northern hardwood region. By 1995, grade 1 Common Northern red oak was selling at prices nearly 40% higher than for similar Southern red oak. This paper examines Northern, Appalachian, and Southern green and air-dried prices for three major grades of red oak lumber, and relates these changes to regional differences in the red oak resource and growing conditions and changes in the industries that use red oak lumber. The results of this analysis should be useful in evaluating the profitability of precommercial thinning and other short-term management practices used to increase the value of red oak sawtimber. North. J. Appl. For. 14(4):173-177.
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Iosub, Diana, Rosa Trotti, and Franco Piovella. "The Measure of Plasma Concentrations Is Crucial in Managing Dabigatran Treatment in Non-Valvular Atrial Fibrillation." Blood 124, no. 21 (2014): 5088. http://dx.doi.org/10.1182/blood.v124.21.5088.5088.
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Abstract One of the most popular features utilized to promote direct oral anticoagulants diffusion in stroke prevention in non-valvular atrial fibrillation is that these drugs do not require monitoring of their anticoagulant activity or plasma level measurements. We believe that there are clinical scenarios in which monitoring can help guide clinical management. Here we describe a clinical case in which close monitoring of thrombin inhibitor dabigatran peak plasma levels helped in maintaining the patient drug administration schedule, despite the interference of mirabegron, a beta-3 adrenergic agonist, utilized for the symptomatic treatment overactive bladder (OAB) syndrome, and of amiodarone, an effective and commonly prescribed antiarrhythmic drug. These P-glycoprotein (P-gp) inhibitors drugs may increase the blood levels and effects of dabigatran. Combining these medications may increase the risk of bleeding complications and anemia, especially when associated to mild to moderate renal insufficiency. Dabigatran etexilate is a pro-drug that has a low (3%-7%) bioavailability. Once dabigatran etexilate is absorbed, the pro-drug is hydrolyzed to the active drug, dabigatran, by carboxylesterases in the bloodstream. Dabigatran etexilate is a substrate of the efflux transporter P-gp, but dabigatran, the active drug, is not. P-gp is present on the luminal side of absorptive cells in the small intestine and takes drug molecules from the cell cytoplasm and transports them back into the intestinal lumen for excretion. An inhibitor of P-gp, as mirabegron or amiodarone, will increase bioavailability of a P-gp substrate by reducing drug efflux. Our patients suffers from persistent non-valvular atrial fibrillation, complicated by ischemic stroke. He has been assigned a dabigatran 150 mg b.i.d. treatment in may 2014. His creatinine clearance was 75 mL/min. One month later, due to OAB syndrome, he started mirabegron, a drug which might potentially increase the risk of bleeding and which generally causes to stop dabigatran administration. We decided instead to set up a monitoring plan, utilizing plasma-diluted thrombin time to measure dabigatran concentrations. Calibration material consisted of pooled normal plasma with known quantities of dabigatran. By using this calibration material, we constructed a dose-response curve ranging from 0 to 500 ng/mL of dabigatran. An examination of the published literature of the pharmacology of dabigatran indicated that the expected peak steady-state concentration of dabigatran in patients with atrial fibrillation (150 mg, 2 times daily) was approximately 180 ng/mL with a trough of approximately 90 ng/mL (12 hours after last dose). After 4 weeks of mirabegron administration, dabigatran plasma trough level of our patient was 126.4 ng/mL. We therefore decided not to modify the 150 mg b.i.d. treatment. Three weeks later, patient suffered from acute cardiac failure associated to a creatinine clearance reduction to 41 mL/min. As a consequence, mirabegron treatment was stopped. At this point, dabigatran plasma trough level was 148.6 ng/mL. Again, we decided not to modify the 150 mg b.i.d. treatment. Six weeks later, due to an elevated cardiac rate (140/min) a treatment with 300 mg o.d. of amiodarone was started. A week later dabigatran plasma trough level was 219.6 ng/mL, with a creatinine clearance of 58mL/min. We decided then to reduce the administration of dabigatran to 110 mg twice daily. After two weeks, dabigatran plasma trough level lowered to 120.2 ng/mL. Our patient is still on dabigatran treatment which has so far never been stopped. At this time, studies addressing the correlation of dabigatran concentration with risk of bleeding (overdose) or breakthrough thrombosis (underdosing) are unavailable. The lack of such studies currently limits the predictive power of the plasma-diluted thrombin time to determine hemorrhage/thrombosis risk. However, we believe that in situations like our patient’s the adoption of this assay would be a valuable tool to aid adjusting dabigatran treatment. With access to appropriate pharmacodynamic and pharmacokinetic data and relevant calibration material, the plasma–diluted thrombin time assay can easily be applied for use in the monitoring dabigatran etexilate. Disclosures No relevant conflicts of interest to declare.
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De Backer, S., K. Chiers, and L. Van Brantegem. "Oak leaf (Quercus spp.) intoxication in a sheep." Vlaams Diergeneeskundig Tijdschrift 90, no. 3 (2021): 133–37. http://dx.doi.org/10.21825/vdt.v90i3.20412.
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A twenty-year-old ewe presented with acute lateral decubitus, tremor and dyspnea, followed by death. Post-mortem examination revealed a large amount of oak leaves in the rumen, reticulum and omasum. The duodenum had a focal hemorrhagic content and multifocal hemorrhages were present in several organs. Histopathological examination of the kidneys showed characteristic lesions of oak intoxication, such as intratubular hemorrhage, tubular degeneration and necrosis. This case report illustrates the importance to include oak intoxication in the differential diagnosis of acute death in sheep and the value of post-mortem and histopathological examination.
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Khararjian, Armen, Prakash Mathew, Ajuni Choudhary, and Alexander Baras. "Cost Effectiveness of Intraoperative Gross Examination in Colorectal Resections: A Retrospective Review of 200 Consecutive Cases." Archives of Pathology & Laboratory Medicine 142, no. 11 (2018): 1403–6. http://dx.doi.org/10.5858/arpa.2017-0201-oa.
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Context.— Intraoperative pathology consultation is an important tool for many surgical procedures and is deemed appropriate when the pathology result immediately alters surgical management. Objective.— To evaluate the utility of intraoperative gross examinations of colorectal resections and to better understand the associated costs. Design.— The pathology database of our institution was searched for colorectal resections for primary disease, and those cases were separated into 3 categories: frozen section performed, intraoperative gross examination performed, and no intraoperative consultation. We reviewed 270 cases during a 15-month period. Results.— Of the 270 cases, 200 (74.1%) had an intraoperative gross examination. In 34 of the 200 cases (17%), additional specimens were taken and, therefore, required operative note review to ascertain whether the additional specimens taken were based on the findings from the intraoperative gross examination. After reviewing the operative notes for those 34 cases, none (0%) were a result of the gross findings reported. The average associated time for intraoperative gross examinations was 27.67 minutes (including transport). The billable costs exceeded $7000 during the study period, and the cost of the pathology assistant's time per case was $22.10. Conclusions.— Our study demonstrates that no change in surgical management was a result of gross examination of colorectal resection specimens and that the associated costs were significant. Decreasing unnecessary consultations will directly save the health care system money by eliminating billable services and will also increase the efficiency of the pathology department by reducing the opportunity costs for the time of the pathologist and the pathology staff.
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Ugiagbe, Ezekiel E., and Osarumwense D. Osifo. "Postmortem Examinations on Deceased Neonates: A Rarely Utilized Procedure in an African Referral Center." Pediatric and Developmental Pathology 15, no. 1 (2012): 1–4. http://dx.doi.org/10.2350/10-12-0952-oa.1.
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Postmortem examination remains the gold standard for the correct diagnosis of many diseases and for unraveling unexplained causes of death. This paper reports on the poor utilization of autopsy services and encourages parents/caregivers and practitioners to perform postmortem examinations on deceased neonates in sub-Saharan Africa. In a retrospective study, the records of 1093 neonates (653 males and 440 females, ratio 1.5:1) who died at the University of Benin Teaching Hospital and who were brought to the mortuary between 2006 and 2010 were reviewed to determine the utilization of and factors influencing postmortem examination. Sixty-two percent of the neonates died within the 1st week of life, and only 9 (0.8%) underwent a postmortem examination. Findings in the 9 postmortem studies performed on 7 males and 2 females provided additional information on the causes of death. The religious beliefs that neonates should not be subjected to postmortem study and beliefs that dead neonates are taboo and a punishment by the gods for past wrongdoings influenced 511 (46.8%) parents/caregivers to refuse postmortem analysis. The practitioners did not request postmortem study in 281 (25.7%) of the cases. The utilization of postmortem examination was marginal in this setting. We advocate the need for public enlightenment campaigns to modify the attitudes of parents/caregivers toward the postmortem study of deceased neonates. Policies should be formulated to mandate postmortem examinations of deceased neonates to enhance insight into neonatal disease, unravel unexplained causes of death, and improve the standard of neonatal care in this subregion.
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Simakova, Irina Leonidovna, and Svetlana Anatol’yevna Serdyukova. "Some aspects of the comparative characteristics of different computerized perimetry methods." Ophthalmology journal 8, no. 2 (2015): 5–9. http://dx.doi.org/10.17816/ov201525-9.
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Purpose - to compare the ease of use, the comfort for persons to be tested, the examination rate, as well as the variability of repeated results obtained using four methods of computerized perimetry. Materials and methods. This clinical study included three groups of patients with open-angle glaucoma (OAG). The 1st group included patients with OAG stage I, the 2nd group - with OAG stage II, the 3rd group - with OAG stage III. The control group included healthy individuals. All tested persons underwent examinations by 4 computerized methods (HFA II, Tomey AP-1000, Pericom, and the FDT-perimetry modification developed at the Ophthalmology Department of the Military Medical Academy). Results. FDT-perimetry appeared to be the shortest, easiest test and most comfortable for tested persons. Perimetry using Tomey AP-1000, Pericom and HFA II was more time-consuming and more difficult to perform. Repeated results of all four methods were better than the first one due to the “learning curve” effect, and showed different variability. Conclusion. To obtain reliable computerized perimetry results, taking into account the possible “learning curve” effect, we recommend repeating the perimetric test at least 2-3 times at same conditions. It is important for the selected perimetric test to be easy to perform, comfortable for persons to be tested, and quite fast to perform.
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Alam, Md Naushad, Md Fazal Naser, Kamrun Nahar, et al. "Association of Detrusor Muscular Activity With the Outcome of Transurethral Resection of Prostate in Patients With Severity of Bladder Outflow Obstruction." Bangladesh Journal of Urology 18, no. 2 (2020): 56–61. http://dx.doi.org/10.3329/bju.v18i2.49277.
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Objective: To evaluate the association of detrusor muscular activity with outcome of TURP in patients with severity of bladder outflow obstruction.
Methods: This is a hospital based cross sectional study conducted in the Department of Urology of Dhaka Medical College Hospital, Dhaka.Elderly male patients having lower urinary tract symptoms (IPSS=20-35) with no retention (non-catheterized patient), who attended in Dhaka Medical College Hospital, were included in the study. A total of 73 patients meeting the enrollment criteria were included in the study. They were evaluated by history, physical examination including DRE and necessary investigations to identify the potential candidates for TURP. Then the potential participants were counseled for Urodynamic study. All patients underwent TURP by expert surgeon. Three months after TURP, repeat Urodynamic study was done and the results were compared to see the outcome. Afterward the data were plotted for the clarification of detrusor contractility at three levels: normal detrusor contractility (voiding pressure 40-60cm of water), detrusor over activity (voiding pressure >60cm of water) and detrusor under activity (voiding pressure <40 cm of water). According to the provisional ICS nomogram for the analysis of voiding, patients were divided into three classes. In BOO Index(PdetQmax-2Qmax),obstructed(BOOI > 40); equivocal(BOOI=20-40);Unobstructed(BOOId” 20) are taken into consideration. The test statistic used to analyze the data was descriptive statistics and ANOVA test. The level of significance was set at 0.05 and P<O.05 was considered significant.
Results: Out of 73 patients 8 didn’t attend follow up session and hence excluded keeping 65 for final analysis. The mean age was 66.3 ± 9.7 years (50- 87 years) .Detrusor over activity was present in 13(20%), normal detrusor contractility was observed in 46(70.8%) and weak contractility in 6(9.2%). Peak urinary flow rate was almost similar among patients of different groups. However, voided volume and residual volume were lowest in overactive group and highest in underactive group, while normal group was in between two (p = 0.007 and p = 0.046 respectively). Maximum urinary flow rate and voided urine between patients of moderate and severe bladder outlet obstruction were almost comparable (p =0.120 and p = 0.270 respectively). However, residual urine volume was much higher in the patients of moderate BOO than that in severe BOO (p = 0.001).The patients of OAB experienced a significant improvement in percentage of reduction of residual urine volume compared to normal and underactive bladder (p = 0.002), However, there were no significant difference among the patients with overactive, normal and underactive bladder with respect to peak urinary flow rate and voided urine volume (p = 0.499 and p = 0.847 respectively).
Conclusion: TURP is an effective surgical procedure for treatment of BPH, especially for patients with severe degree of BOO with normal or overactive detrusor contraction.
Bangladesh Journal of Urology, Vol. 18, No. 2, July 2015 p.56-61
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KAMATA, YOSHIHIRO. "Examination of OAE in non hearing loss ear noise." AUDIOLOGY JAPAN 41, no. 5 (1998): 559–60. http://dx.doi.org/10.4295/audiology.41.559.
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Sultana, Saleha, Syed Abdul Wadud, Shabeena Huda, and Sharfuddin Ahmed. "Open angle glaucoma, glaucoma suspect and ocular hypertension in thyroid related immune orbitopathy and other thyroid diseases." Bangabandhu Sheikh Mujib Medical University Journal 8, no. 1 (2016): 50. http://dx.doi.org/10.3329/bsmmuj.v8i1.28921.
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<p><strong>Background:</strong> The eye changes associated with thyroid disease are referred to as Thyroid related Orbitopathy. A well described association exist between open angle glaucoma and thyroid related orbitopathy, the possible relationship between open angle glaucoma and either hypothyroidism or hyperthyroidism without orbitopathy is variable.</p><p><strong>Objective:</strong> To observe the relation of open angle glaucoma (OAG), glaucoma suspect (GS) and ocular hypertension(OHT) between Thyroid related immune orbitopathy (TRIO) and other thyroid diseases (toxic multinodular goiter and hypothyroidism).</p><p><strong>Method:</strong> With purposive type of sampling technique 40 patients of Graves' disease disease in Group-A and 40 patients of other thyroid diseases in Group-B which was subdivided into 20 patients of toxic multinodular goiter in Group-B 1, 20 patients of hypothyroidism in Group-B2 were selected in Bangabandhu Sheikh Mujib Medical University (BSMMU) for this cross sectional study. The diagnosis of Graves' disease, toxic multinodular goiter and hypothyroidism were carried out by history, clinical examination and clinical test in endocrinology department. All the patients underwent complete ocular examinations, measuring of intraocular pressure (IOP), fundus examination, visual field analysis, gonioscopy and exophthalmometry.</p><p><strong>Result:</strong> The OAG, GS and OHT was 7.5% (3 cases), 5.0% (2 cases) and 17.5% (7 cases) respectively in Group-A. In contrast OAG, GS was 5% (lease), 5% (1 case) respectively in Group-Bl, only 5% (1 case) OAG in Group-B2. There was no incidence of OHT in Group-B (B1+B2). Although the occurrence of OAG and GS were higher in Group-A than Group-B, this difference was not statistically significant (p>0.05). However OHT was more common in Group-A than Group-B and is statistically significant (p<0.05). Among the 12 patients with OAG, GS and OHT in Group-A, 11 had ≥22mm exophthalmos. In Group-A, ≥22mm exophthalmos in 60% cases, in contrast none of Group-B have ≥22mm.</p><p><strong>Conclusion:</strong> The occurrence of OHT was higher in thyroid related immune orbitopathy than other thyroid diseases.</p>
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Trenyik, Petra, Orsolya Szirmai, Attila Barczi, Julianna Skutai, and Szilárd Czóbel. "Examination on the State of Health Regarding a Protected Sessile Oak Stock." Analecta Technica Szegedinensia 10, no. 2 (2016): 23–28. http://dx.doi.org/10.14232/analecta.2016.2.23-28.
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It can be observed in more and more fields of science that the results of other disciplines are utilised in order to achieve new results; it is true for nature conservation as well. Global climate change is to be considered as one of the most thoroughly studied topic; scientists pay special attention to the responses given by species and communities to climate change. In case of field examinations the accuracy of samplings and measurements is of key importance. Often solely estimated data is available which deteriorates the accuracy of the assessment. The health status of forests is usually determined by visual observations that imply errors due to human subjectivity. In this examination we surveyed the health status of a protected sessile oak stock within the Botanical Garden of Szent István University in Gödöllő by using not only conventional methods but also instrumental measurements. We have used FAKOPP 3D Acoustic Tomograph. It is an instrument developed in Hungary that is able to determine – in percentage – the extent of deterioration in tree trunks. The method of measurement is the following: this instrument measures the speed of sound propagation in the tree matter, since rotten and healthy tissues conduct sound differently. Prior to the examination we surmised that a predominantly healthy stock would be examined. Nevertheless, instrumental measurements proved that the trees of this stock are considerably decayed; therefore constant instrumental monitoring is required. We found that the extent of decomposition was the most significant in the lowest measurement level (i.e. 40 cm – Layer 1) and it steadily decreased in the higher regions.
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Gawron, Lori M., Cassing Hammond, and Linda M. Ernst. "Perinatal Pathologic Examination of Nonintact, Second-Trimester Fetal Demise Specimens: The Value of Standardization." Archives of Pathology & Laboratory Medicine 137, no. 8 (2013): 1083–87. http://dx.doi.org/10.5858/arpa.2012-0010-oa.
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Context.—Management of second-trimester intrauterine fetal demise via dilation and evacuation results in nonintact specimens for pathologic examination. Surgical pathology examination is often mandated; however, evidence on expected findings and specimen evaluation guidelines are lacking. Objectives.—To assess pathologic findings of nonintact, second-trimester fetal demise specimens, through comparison of anatomic abnormalities identified on standardized perinatal examination to individualized general pathology examinations. Design.—Single institution, retrospective chart review of 14- to 24-week gestational size fetal demise cases was conducted from May 2006 to October 2010. Suspected abnormalities, chromosomal and pathologic diagnoses were collected. A general surgical pathology examination occurred between May 2006 and October 2008, while a perinatal pathologist examined specimens between October 2008 and October 2010. Statistical analysis consisted of t tests and χ2 tests by Stata/SE 12.1. Results.—One hundred eighteen specimens were included and mean gestational size was 16.0 weeks (standard deviation, 1.6 weeks). Perinatal pathologic evaluation diagnosed significantly more abnormalities than did general pathologic examination (77.3% [34 of 44] versus 9.5% [7 of 75], P < .001). Forty-eight abnormalities were identified: 77.0% (n = 37) were placental and 23.0% (n = 11) were fetal. Chromosomal analysis was done on 73.7% (n = 87 of 118) with 12.6% (n = 11 of 87) showing abnormalities. Among aneuploid specimens, the perinatal pathologist confirmed abnormalities in 66.7% (n = 4 of 6) of cases while general pathologists confirmed abnormalities in 0% (n = 0 of 5) (P = .02). Conclusions.—Systematic surgical pathology examination of nonintact, second-trimester fetal demise specimens yields increased information on fetal or placental abnormalities, which may be clinically useful. Institutions with high-risk obstetrical practices and dilation and evacuation providers should consider integrating a standardized perinatal checklist into educational and practice guidelines.
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CHIDA, EIJI. "OAE. Comparison examination between ear acoustic emission and hearing acuity." AUDIOLOGY JAPAN 38, no. 5 (1995): 393–94. http://dx.doi.org/10.4295/audiology.38.393.
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Shin, Yong Un, Eun Hee Hong, Min Ho Kang, Heeyoon Cho, and Mincheol Seong. "The Association between Female Reproductive Factors and Open-Angle Glaucoma in Korean Women: The Korean National Health and Nutrition Examination Survey V." Journal of Ophthalmology 2018 (June 20, 2018): 1–8. http://dx.doi.org/10.1155/2018/2750786.
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Purpose. We investigated associations between female reproductive factors and open-angle glaucoma (OAG) in Korean females using the Korea National Health and Nutrition Examination Survey (KNHANES). Methods. A nationwide, population-based, cross-sectional study was conducted. We enrolled 23,376 participants from the KNHANES who had undergone ophthalmologic exams from 2010 through 2012. Associations between undiagnosed OAG and female reproductive factors such as age at menarche and menopause, parity, history of lactation, and administration of oral contraceptives (OC) or hormone replacement therapy (HRT) were determined using stepwise logistic regression analyses. Results. Of the enrolled participants, 6,860 participants (397 with OAG and 6,463 without OAG) met our study criteria and were included in the analyses. In the multivariate logistic regression analysis after adjusting for all potential confounding factors, only early menopause (younger than 45 years) was significantly associated with OAG in participants with natural menopause (OR 2.28, 95% CI 1.17–4.46). Age at menarche, parity, history of lactation, and administration of OC or HRT were not significantly associated with OAG. Conclusions. Only early menopause was associated with an increased risk of OAG in our study, in contrast to previous Western studies reporting both early menopause and late menarche as associated factors.
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Song, Ji Eun, Joon Mo Kim, Mi Yeon Lee, Hye Joo Jang, and Ki Ho Park. "Effects of Consumption of Alcohol on Intraocular Pressure: Korea National Health and Nutrition Examination Survey 2010 to 2011." Nutrients 12, no. 8 (2020): 2420. http://dx.doi.org/10.3390/nu12082420.
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This study researched the association between alcohol consumption, intraocular pressure (IOP), and risk of open-angle glaucoma (OAG) using nationwide population-based cross-sectional data from the Korean population based survey. Information on alcohol intake was obtained by questionnaire and comprehensive ophthalmic examinations were performed. Among a total of 6057 participants, the prevalence of OAG was 4.4% (6.0% for men and 3.0% for women). Multivariate adjusted models showed that alcohol consumption showed significant relationship with changes in IOP. In sex-stratified analyses, alcohol consumption more than 2 times per week was associated with increased IOP in men without OAG, while in women with OAG drinking alcohol more than 4 times per week was associated with increased IOP. This study showed significant differences between men and women without glaucoma who consumed alcohol more than four times per week (p-value: 0.03). Our results suggest that alcohol consumption is associated with risk of elevated IOP depending on sex and presence of glaucoma in Koreans. Therefore, patients who need to control IOP should consider the effects of alcohol consumption.
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Bramantyo, Brastho, Jenny Bashiruddin, Widayat Alviandi, and Risdawati Risdawati. "Pemeriksaan Otoacoustic Emission (OAE) untuk menilai keberhasilan terapi metilprednisolon." Oto Rhino Laryngologica Indonesiana 49, no. 1 (2019): 1. http://dx.doi.org/10.32637/orli.v49i1.285.
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Latar belakang: Penatalaksanaan tuli mendadak menggunakan steroid sebagai terapi utama merupakan hasil konsensus terapi tuli mendadak tahun 2010 di Madrid-Spanyol dan Cochrane systematic review tahun 2009, yang saat ini diterapkan di Divisi Neurotologi Departemen Telinga Hidung Tenggorok-Kepala Leher Rumah Sakit Cipto Mangunkusumo. Evaluasi hasil pengobatan dilakukan dengan pemeriksaan audiometri dan Distortion Product Otoacoustic Emission (DPOAE). Pasien yang mengalami kesembuhan akan memperlihatkan peningkatan ambang dengar dan nilai Signal to Noise Ratio (SNR) emisi otoakustik. Tujuan: Mengevaluasi hasil terapi metilprednisolon dosis terbaru pada tuli mendadak dengan pemeriksaan DPOAE dan audiometri nada murni. Metode: Penelitian ini menggunakan desain pre dan post eksperimental. Diberikan terapi metilprednisolon 1 mg/kgBB dengan tapering off 20 mg setiap 5 hari. Dilakukan pemeriksaan DPOAE dan audiometri sebelum dan setelah terapi. Hasil: Total sampel yang diolah adalah 22 subjek. Penelitian ini mendapatkan perubahan yang bermakna nilai audiometri nada murni sebelum dan sesudah terapi pada semua frekuensi. Nilai SNR pada OAE sebelum dan setelah terapi rata-rata mengalami perubahan nilai pass, dengan perubahan nilai SNR pass terbanyak adalah pada frekuensi 8000 Hz (6 subjek). Tingkat perubahan ambang dengar sesudah terapi yang mengalami perbaikan paling banyak pada frekuensi 2000 Hz, 3000 Hz, 6000 Hz dengan masing-masing 16 subjek. Perbaikan emisi terjadi lebih awal dibandingkan perbaikan ambang dengar. Kesimpulan: Pada penelitian ini terdapat perubahan bermakna nilai audiometri, dan nilai DPOAE. Didapatkan hubungan bermakna perubahan SNR pada OAE dengan tingkat perubahan ambang dengar frekuensi 8000 Hz dan 10.000 Hz, setelah pengobatan metilprednisolon sesuai protokol penelitian ini. Background: Methylprednisolone as a drug of choice in sudden deafness was consented in Madrid, Spain 2010 and in Cochrane systematic review in 2009, and already applied in Neurotology Division, ENT Department Cipto Mangunkusumo Hospital. Sudden deafness treatment evaluation conducted by audiometry and Distortion Product Otoacoustic Emission (DPOAE) examinations. Hearing recovery could be assessed from the improvement of hearing threshold and Signal to Noise Ratio (SNR) of otoacoustic emission (OAE). Objective: To evaluate the current dose of methylprednisolone therapy for sudden deafness, by DPOAE and pure tone audiometry. Methods: This was a pre-post experimental study using methylprednisolone 1 mg/kg body weight tapered off 20 mg in every 5 days. DPOAE and audiometry examination were conducted pre and post therapy. Result: Total sample were 22 subjects. Significant improvement was seen in overall frequencies of audiometry examination. Pass result in SNR of OAE showed remarkable improvement in 8000 Hz (6 subjects). The level of pure tone threshold mainly increased in frequencies of 2000 Hz, 3000 Hz, and 6000 Hz, each 16 subjects. Improvement of the emision level occurred earlier than the hearing threshold. Conclusion: This study revealed significant improvement of audiometry threshold and OAE level. Significant correlation was found between SNR of OAE improvement with increased pure tone level in 8000 Hz and 10.000 Hz after methylprednisolone therapy according to the protocol of this study.
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Buys, Yvonne M., Paul Harasymowycz, Rania Gaspo, et al. "Comparison of Newly Diagnosed Ocular Hypertension and Open-Angle Glaucoma: Ocular Variables, Risk Factors, and Disease Severity." Journal of Ophthalmology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/757106.
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Purpose. To describe the distribution of ocular variables, risk factors, and disease severity in newly diagnosed ocular hypertension (OH) or open-angle glaucoma (OAG).Methods. Eligible subjects underwent a complete history and examination. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) obtained from multiple logistic regression models were used to compare OAG to OH and advanced to early/moderate OAG.Results. 405 subjects were enrolled: 292 (72.1%) with OAG and 113 (27.9%) with OH. 51.7% had early, 27.1% moderate, and 20.9% advanced OAG. The OR for OAG versus OH was 8.19 (P<0.0001) for disc notch, 5.36 (P<0.0001) for abnormal visual field, 1.45 (P=0.001) for worsening mean deviation, 1.91 (P<0.0001) for increased cupping, 1.03 for increased age (P=0.030), and 0.36 (P=0.010) for smoking.Conclusions. Increased age was a risk for OAG, and smoking decreased the risk of OAG compared to OH. Almost half of the OAG subjects had moderate/advanced disease at diagnosis.
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Monks, Gregory G. "Quit blubbering: an examination of Nuu'chah'nulth (Nootkan) whale butchery." International Journal of Osteoarchaeology 11, no. 1-2 (2001): 136–49. http://dx.doi.org/10.1002/oa.552.
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Daradkeh, Mohammad Kamel. "An Empirical Examination of the Relationship Between Data Storytelling Competency and Business Performance." Journal of Organizational and End User Computing 33, no. 5 (2021): 42–73. http://dx.doi.org/10.4018/joeuc.20210901.oa3.
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With the proliferation of big data and business analytics practices, data storytelling has gained increasing importance as an effective means for communicating analytical insights to the target audience to support decision-making and improve business performance. However, there is a limited empirical understanding of the relationship between data storytelling competency, decision-making quality, and business performance. Drawing on the resource-based view (RBV), this study develops and validates the concept of data storytelling competency as a multidimensional construct consisting of data quality, story quality, storytelling tool quality, storyteller skills, and storyteller domain knowledge. It also develops a mediation model to examine the relationship between data storytelling competency and business performance, and whether this relationship is mediated by decision-making quality. Based on an empirical analysis of data collected from business analytics practitioners, the results of this study reveal that the data storytelling competency is positively linked to business performance, which is partially mediated by decision-making quality. These results provide a theoretical basis for further investigation of possible antecedents and consequences of data storytelling competency. They also offer guidance for practitioners on how to leverage data storytelling capabilities in business analytics practices to improve decision-making and business performance.
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Nedir, Rabah, Nathalie Nurdin, Marion Paris, Marc El Hage, Semaan Abi Najm, and Mark Bischof. "Unusual Etiology and Diagnosis of Oroantral Communication due to Late Implant Failure." Case Reports in Dentistry 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/2595036.
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Oroantral communication (OAC) rarely occurs long after implant placement. The present report describes the rare etiology and the difficulty of the diagnosis of an uncommon OAC occurring 10 years after the implant placement in the posterior maxilla. The difficulty of the diagnosis lies in the absence of clinical symptoms of sinusitis and presence of multiunit prosthesis hiding implant failure. This case report supports the need for sinus check-up during a routine implant examination.
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Xu, Zical, Theodor D. Leininger, James G. Williams, and Frank H. Tainter. "Examination of the Arborsonic Decay Detector for Detecting Bacterial Wetwood in Red Oaks." Southern Journal of Applied Forestry 24, no. 1 (2000): 6–10. http://dx.doi.org/10.1093/sjaf/24.1.6.
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Abstract The Arborsonic Decay Detector (ADD; Fujikura Europe Limited, Wiltshire, England) was used to measure the time it took an ultrasound wave to cross 280 diameters in red oak trees with varying degrees of bacterial wetwood or heartwood decay. Linear regressions derived from the ADD readings of trees in Mississippi and South Carolina with wetwood and heartwood decay yielded significantly different lines for some combinations and locations. The results of this study suggest that the ADD cannot yet be used to detect wetwood in oak trees with enough certainty to be of practical use to a forester or land manager. However, regression lines describing ADD readings of trees with wetwood at both study sites were located between those of healthy trees and decayed trees suggesting some, albeit limited, ability to differentiate wetwood trees. The use of ultrasound to detect bacterial wetwood in red oaks may be improved by designing a system that allows measurement of signal amplitude and evaluation of waveform patterns. The ability to successfully detect trees with heartwood decay was better, especially for trees with advanced decay. South. J. Appl. For. 24(1):6-10.
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Tabaković-Tošić, Mara, and Marija Milosavljević. "Examination of the correlation between the defoliation caused by nutrition of the brown-tail moth larvae and the increment of infested Sessile oak and Turkey oak trees." Sustainable Forestry: Collection, no. 77-78 (2018): 89–98. http://dx.doi.org/10.5937/sustfor1877089t.
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The paper presents the results of the study research on the effect of the leaf mass reduction caused by the intensive nutrition of an oak defoliating insect - the brown-tail moth Euproctis chrysorrhoea on the annual increment of sessile oak and Turkey oak trees in the coppice forests of the Novi Pazar region (SE Srbijašume, FE Šumarstvo Raška, Novi Pazar Forest Administration, FMU Blizanac-Debelica and FMU NinajaKoznik).
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NISHIJIMA, TAKASHI. "OAE II.Comparative examination of various oto-acoustic emissions in ortho-auditory adults." AUDIOLOGY JAPAN 38, no. 5 (1995): 411–12. http://dx.doi.org/10.4295/audiology.38.411.
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Franic, Zrinka, Zeljka Babic, and Jelena Macan. "O5B.3 Skin health in croatian hairdressing apprentices at the beginning of vocational education: a new cohort study." Occupational and Environmental Medicine 76, Suppl 1 (2019): A43.3—A44. http://dx.doi.org/10.1136/oem-2019-epi.118.
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IntroductionHairdressing apprentices are at high risk of developing occupational contact dermatitis.Materials and methodsData on skin health are presented for 352 hairdressing apprentices attending vocational schools in 24 Croatian towns at the beginning of their education, in a screening phase of a prospective cohort study. Apprentices were recruited from September to December 2017. The study protocol included: Nordic Occupational Skin Questionnaire and International Study on Asthma and Allergy in Children Questionnaire for the evaluation of self-reported skin and atopy symptoms, clinical skin examination interpreted by means of Osnabrueck Hand Eczema Severity Index (OHSI), genotyping filaggrin (FLG) gene polymorphisms 2282del4 and R501X from buccal swabs, skin pH and transepidermal water loss (TEWL) measurements.ResultsIn the total sample (n=352, median age 15, 18 males), a history of respiratory and/or skin atopy symptoms was reported by 44.89%, hand/wrist eczema by 11.93%, and a history of dry hands (without eczema) by 34.38% of apprentices. One or more hand/wrist skin changes were found at the clinical examination in 18.18% of apprentices, with the OHSI score ranging from 1 to 6. Washing hands>20 times per day was identified in 12.78% of apprentices. An FLG gene mutation (R501X) was found in only one apprentice. The median (range) for hand TEWL and pH was 13.1 (4.36–62.69) and 5.68 (4.28–7.13), respectively. OHSI score was positively correlated with hand TEWL (Spearman rho 0.16; p=0.0026), and pH (Spearman rho 0.13; p=0.0186).ConclusionThe results indicate a high prevalence of self-reported atopy (45%) and moderate prevalence of self-reported (12%) and clinically observed skin symptoms (18%) on the hands/wrists of hairdressing apprentices already at the beginning of education, without FLG mutations as a risk factors. This emphasizes the need to ameliorate preventive examinations of children before enrolling to schools for professions with high risk of exposure to skin hazards.
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Kovacs, Helga, Katalin Szemmelveisz, and Alex Nemes. "Gaseous and Solid Air Pollutants Formed during the Combustion of Heavy Metal Contaminated Oak and Poplar." Advanced Materials Research 875-877 (February 2014): 743–48. http://dx.doi.org/10.4028/www.scientific.net/amr.875-877.743.
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In recent decades several industrial activities polluted the soil, which caused the accumulation of heavy metals to an extent greater than the natural concentration. This is mainly typical of countries, where mining and industry plays or has played an important role in the economy. The utilization of these lands is an economic interest, since locating the contamination, controlling its spreading and maintaining the area has costs. One of the methods for remediation is phytoextraction, during which heavy metals, especially harmful to water and soil, are removed from the soil by plants capable of accumulating contaminants. However, during the combustion of these plants their heavy metal content is replaced into the formed gaseous and solid combustion remains, so the hazard, composition and treating method of these remains must be defined by the appropriate examinations. In this article we present some part of the results of this research, where we examine the gaseous and solid pollutant content of flue gas formed during combustion, as well as the heavy metal content of fly ash. We made two different experiments for domestic and semiplant usage. We have used oak and poplar from a heavy metal contaminated area in both experiments. The domestic examination was conducted in a 7 kW hearth with a closed combustion chamber, the semiplant examination was carried out in a 0,5 MW capacity furnace equipped with an automatic fuel feeding system and a cyclone dust extractor. We have measured the composition of flue gas in both firing experiments with a HORIBA PG-250 type portable gas analyzer, in the case of the analysis of heavy metal content of fly ash DX4 EDAX EDS microprobe of an AMRAY 1830 I scanning electron microscope and ICP-AES, using a 720 ES instrument was used. Based on our results, it can be determined, that the combustion device used to burn biomass grown on heavy metal polluted areas – brownfield lands – must make it possible to separate fly ash from the flue gas and allow the handling of solid burning residues.
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Fang, Christian, Tak-Man Wong, Tak-Wing Lau, Kelvin KW To, Samson SY Wong, and Frankie Leung. "Infection after fracture osteosynthesis – Part I." Journal of Orthopaedic Surgery 25, no. 1 (2017): 230949901769271. http://dx.doi.org/10.1177/2309499017692712.
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Bone and surgical site infections after osteosynthesis are notoriously difficult to manage and pose a tremendous burden in fracture management. In this article, we use the term osteosynthesis-associated infection (OAI) to refer to this clinical entity. While relatively few surgically treated fractures become infected, it is challenging to perform a rapid diagnosis. Optimal management strategies are complex and highly customized to each scenario and take into consideration the status of fracture union, the presence of hardware and the degree of mechanical stability. At present, a high level of relevant evidence is unavailable; most findings presented in the literature are based on laboratory work and non-randomized clinical studies. We present this overview of OAI in two parts: an examination of recent literature concerning OAI pathogenesis, diagnosis and classification and a review of treatment options.
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Фурменкова, Evgeniya Furmenkova, Кочергина, Marina Kochergina, Трегубов, and Oleg Tregubov. "To the problem of increasing stability of plantations of Voronezh upland oak forests." Forestry Engineering Journal 5, no. 4 (2015): 66–78. http://dx.doi.org/10.12737/17404.
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The article is devoted to the definition of forest pathology condition of plantations of biology (for-est) nature monument "Old-growth areas of upland oak forests", located in the quarter 52 of Pravobe-rezhnoe forestry of Prigorodny district forest, Voronezh region. Definition of certain classes of biological sustainability of forests and evaluation of its sanitary condition during the examination of trees on test plots is carried out. The factors reducing the stability of oak trees are indentified and analyzed. Forest pa-thology plants condition were evaluated for three classes of biological sustainability. Sanitary condition of plantations is evaluated.
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Fox, C. Lalueza. "Information obtained from the microscopic examination of cultural striations in human dentition." International Journal of Osteoarchaeology 2, no. 2 (1992): 155–69. http://dx.doi.org/10.1002/oa.1390020207.
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Chen, Pei, Fengwei Xie, Fengzai Tang, and Tony McNally. "Cooperative Effects of Cellulose Nanocrystals and Sepiolite When Combined on Ionic Liquid Plasticised Chitosan Materials." Polymers 13, no. 4 (2021): 571. http://dx.doi.org/10.3390/polym13040571.
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Cellulose nanocrystals (CNCs) and/or sepiolite (SPT) were thermomechanically mixed with un-plasticised chitosan and chitosan/carboxymethyl cellulose (CMC) blends plasticised with 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]). Examination of the morphology of these materials indicates that SPT aggregates were reduced when CNCs or [C2mim][OAc] were present. Inclusion of CNCs and/or SPT had a greater effect on material properties when the matrices were un-plasticised. Addition of SPT or CNCs altered the crystalline structure of the un-plasticised chitosan matrix. Moreover, a combination of SPT and CNCs was more effective at suppressing re-crystallisation. Nonetheless, the mechanical properties and surface hydrophobicity were more related to CNC/SPT–biopolymer interactions. The un-plasticised bionanocomposites generally showed increased relaxation temperatures, enhanced tensile strength, and reduced surface wettability. For the [C2mim][OAc] plasticised matrices, the ionic liquid (IL) dominates the interactions with the biopolymers such that the effect of the nanofillers is diminished. However, for the [C2mim][OAc] plasticised chitosan/CMC matrix, CNCs and SPT acted synergistically suppressing re-crystallisation but resulting in increased tensile strength.
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Rzepecki, Andreas, Mechthild Neyses-Eiden, Thomas Frank, Barbara Diethelm, Franz Herzig, and Willy Tegel. "Missing link in Late Antiquity? A critical examination of Hollstein’s Central European Oak Chronology." Dendrochronologia 54 (April 2019): 20–28. http://dx.doi.org/10.1016/j.dendro.2019.01.003.
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Yoo, Tae Keun, Ein Oh, and Samin Hong. "Is vitamin D status associated with open-angle glaucoma? A cross-sectional study from South Korea." Public Health Nutrition 17, no. 4 (2014): 833–43. http://dx.doi.org/10.1017/s1368980013003492.
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AbstractObjectiveOpen-angle glaucoma (OAG) is one of the major chronic diseases involving the optic nerve. However, little is known about the association between vitamin D and OAG. The present study was conducted to test the hypothesis that lower vitamin D status is associated with greater prevalence of OAG.DesignCross-sectional study. Multivariable logistic regression was performed to examine the relationship between serum 25-hydroxyvitamin D (25(OH)D) and OAG after adjusting for traditional potential confounders. OAG was defined by the criteria of the International Society for Geographical and Epidemiological Ophthalmology.SettingThe Fifth Korean National Health and Nutrition Examination Survey conducted in 2010–2011.SubjectsSix thousand and ninety-four adult participants randomly selected from 192 surveys in 131 locations in South Korea.ResultsMultivariable-adjusted odds ratios of OAG across quintiles of decreasing 25(OH)D were 1·26, 1·00 (reference), 1·31, 1·36 and 1·69 (P for quadratic trend <0·01). The odds ratio for the lowest 25(OH)D quintile was significantly higher than that for the second quintile (P < 0·01). In addition, we discovered that the predictors for worsening of OAG, such as intraocular pressure or vertical and horizontal cup-to-disc ratios, had a significant relationship with 25(OH)D level.ConclusionsThere was a reverse J-shaped association between 25(OH)D levels and the risk of OAG, with significantly elevated risk at lower 25(OH)D. The findings of this research suggest that vitamin D deficiency should be considered as a potential risk factor for the development of OAG. To our knowledge, the present study is the first one that shows an association between vitamin D status and OAG.
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Melikian, M., and T. Waldron. "An examination of skulls from two British sites for possible evidence of scurvy." International Journal of Osteoarchaeology 13, no. 4 (2003): 207–12. http://dx.doi.org/10.1002/oa.674.
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Krivotulova, I. A., T. V. Chernysheva, and K. V. Korochina. "Capabilities of ultrasonography in the diagnosis of early rheumatoid arthritis and hand osteoarthritis." Modern Rheumatology Journal 15, no. 2 (2021): 35–42. http://dx.doi.org/10.14412/1996-7012-2021-2-35-42.
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Objective: to compare results of ultrasound examination (US) of the wrist joints (WJ) and small joints of hands with the clinical signs in patients with early rheumatoid arthritis (eRA) and hand osteoarthriti (OAH).Patients and methods. The study included 42 patients with eRA (group 1) and 38 patients with OAH (group 2). The average age of patients with eRA was 48.60±14.86 years, the duration of clinical manifestations was 7.45±1.77 months, of patients with OAH – 54.97±12.45 years and 8.26±1.83 months, respectively. The ratio of men and women in both groups was approximately the same, the majority were women. All patients with eRA had clinical and instrumentally confirmed signs of OA: I, II, and III radiological stages of OA according to Kellgren–Lawrence were detected in 10 (23.80%), 23 (54.76%) and 9 (21.43%) patients respectively. In erosive OA II and III X-ray stage was diagnosed in 16 (42.10%) and 22 (57.90%) patients, respectively. All patients underwent ultrasound of the joints, as well as a general clinical examination, which included an assessment of the number of painful joints, the number of swollen joints, and a general assessment of pain intensity using a visual analogue scale (100 mm). RA activity was determined using the DAS28 index. We also studied laboratory parameters – the levels of CRP, rheumatoid factor and antibodies to cyclic citrullinated peptide in blood serum.Results and discussion. Comparison of the two groups of patients showed that ultrasound in B-mode and power Doppler mode with eRA and OAH showed more pronounced inflammatory and destructive changes in the wrist joints and small joints of the hands, with the exception of the distal interphalangeal joints (DIPJ). In addition, only in patients of the 1st group there was a close correlation between the enhancement of the Doppler signal and levels of inflammatory markers. Conclusion. eRA compared with OAH is characterized by more pronounced ultrasound signs of inflammatory and destructive changes in the wrist joins and small joints of the hands, with the exception of DIPJ.
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van Minnen, B., B. Stegenga, J. Zuidema, et al. "An animal model for oroantral communications: a pilot study with Göttingen minipigs." Laboratory Animals 39, no. 3 (2005): 280–83. http://dx.doi.org/10.1258/0023677054306953.
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A pilot study was performed to investigate whether the Göttingen minipig is a suitable animal model for creating and closing oroantral communications (OACs) and to test whether these defects can be closed with a biodegradable polyurethane (PU) foam. In three adult minipigs, an OAC was created on both sides of the maxilla. The left side was closed by a standard surgical buccal flap procedure, the right side by applying a PU foam. The pigs were killed after two weeks, one month and three months, respectively. Postmortem and histological examination showed that an OAC was created in only one of six cases. In the remaining cases, the infraorbital canal was perforated instead of the floor of the maxillary sinus. It was concluded that the Göttingen minipig is not a suitable animal model for OAC investigations. As a result, the closure of OACs with a biodegradable PU could not be evaluated.
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Del Vecchio Blanco, Giovanna, Rami Dwairi, Mario Giannelli, et al. "Clinical care pathway program versus open-access system: a study on appropriateness, quality, and efficiency in the delivery of colonoscopy in the colorectal cancer." Internal and Emergency Medicine 16, no. 5 (2021): 1197–206. http://dx.doi.org/10.1007/s11739-020-02565-z.
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AbstractOpen-access colonoscopy (OAC), whereby the colonoscopy is performed without a prior office visit with a gastroenterologist, is affected by inappropriateness which leads to overprescription and reduced availability of the procedure in case of alarming symptoms. The clinical care pathway (CCP) is a healthcare management tool promoted by national health systems to organize work-up of various morbidities. Recently, we started a CCP dedicated to colorectal cancer (CRC), including a colonoscopy session for CRC diagnosis and prevention. We aimed to evaluate the appropriateness, the quality, and the efficiency in the delivery of colonoscopy with the open-access system and a CCP program in the CRC. Quality indicators for colonoscopy in subjects in the CCP were compared to referrals by general practitioners (OAC) or by non-gastroenterologist physicians (non-gastroenterologist physician colonoscopy, NGPC). Attendance rate to colonoscopy was greater in the CCP group and NGPC group than in the OAC group (99%, 99%, and 86%, respectively). Waiting time in the CCP group was shorter than in the OAC group (3.88 ± 2.27 vs. 32 ± 22.31 weeks, respectively). Appropriateness of colonoscopy prescription was better in the CCP group than in the OAC group (92 vs. 50%, respectively). OAC is affected by the lack of timeliness and low appropriateness of prescription. A CCP reduces the number of inappropriate colonoscopies, especially for post-polypectomy surveillance, and improves the delivery of colonoscopy in patients requiring a fast-track examination. The high rate of inappropriate OAC suggests that this modality of healthcare should be widely reviewed.
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Kwaśna, Hanna, Piotr Łakomy, and Andrzej Łabędzki. "Morphological characteristics and DNA sequence analysis of Petriella setifera and Oidiodendron setiferum from twigs of diseased oak." Acta Mycologica 40, no. 2 (2014): 267–75. http://dx.doi.org/10.5586/am.2005.024.
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Examination of isolates of <i>Petriella setifera</i> and <i>Oidiodendron setiferum</i> revealed new diagnostic morphological charactcristics. Chlamydosporcs formed by <i>P. setifera</i>, isolated from twigs of sessile oak (<i>Quercus petraea</i>) showing symptoms of oak decline, are described for the first time. The first pictures of <i>P. setifera</i> anamorphs since the publication of its original description in 1912 are presented. Isolates of <i>O. setiferum</i>, from sessile oak twigs and from a log of Scots pine (<i>Pinus sylvestris</i>), were found to have swollen, hyaline, thin-walled, sterile apices on the non-fertile hairs surrounding the fertile heads of conidiophores. They also had numerous coils formed by thin hyphae in the submerged mycelium in agar culture. The taxonomy of both fungi was confirmed by rDNA sequence analysis.
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Karakitsios, V., H. Tsikos, K. Agiadi - Katsiaouni, S. Dermitzoglou, and E. Chatziharalambous. "THE USE OF CARBON AND OXYGEN STABLE ISOTOPES IN THE STUDY OF GLOBAL PALAEOCEANOGRAPHIC CHANGES: EXAMPLES FROM THE CRETACEOUS SEDIMENT ROCKS OF WESTERN GREECE." Bulletin of the Geological Society of Greece 39, no. 1 (2006): 64. http://dx.doi.org/10.12681/bgsg.18445.
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In the present paper we examine the use of carbon and oxygen stable isotopes in the study of global palaeoceanographic changes, with special reference to the oceanic anoxic events (OAEs). The analysis of stable isotopes was applied to the examination of Cretaceous sediments from the Ionian and Pindos zones of Western Greece. In the Ionian zone the carbon and oxygen stable isotopes, combined with biostratigraphic data, record the palaeoenvironmental change corresponding to the anoxic events Bonarelli (Cenomanian/Turonian, OAE2) and Paquier (Lower Albian, OAE1b). In the Pindos zone, within the Cretaceous sediments, we observed two organic-carbon-rich levels. According to the biostratigraphic and isotopie analysis, the first level corresponds to an OAE of Santonian age. This local oceanic anoxic event is described for the first time. The second level, Aptian - Albian age, possibly correlates to either the Paquier event (OAE 1b) or the Selli event (OAE 1a), which in Greece were until now known only in the Ionian zone.
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Feres, Murilo Fernando Neuppmann, Tomas Salomão Muniz, Saulo Henrique de Andrade, Maurilo de Mello Lemos, and Shirley Shizue Nagata Pignatari. "Craniofacial skeletal pattern: is it really correlated with the degree of adenoid obstruction?" Dental Press Journal of Orthodontics 20, no. 4 (2015): 68–75. http://dx.doi.org/10.1590/2176-9451.20.4.068-075.oar.
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OBJECTIVE: The aim of this study was to compare the cephalometric pattern of children with and without adenoid obstruction.METHODS: The sample comprised 100 children aged between four and 14 years old, both males and females, subjected to cephalometric examination for sagittal and vertical skeletal analysis. The sample also underwent nasofiberendoscopic examination intended to objectively assess the degree of adenoid obstruction.RESULTS: The individuals presented tendencies towards vertical craniofacial growth, convex profile and mandibular retrusion. However, there were no differences between obstructive and non-obstructive patients concerning all cephalometric variables. Correlations between skeletal parameters and the percentage of adenoid obstruction were either low or not significant.CONCLUSIONS: Results suggest that specific craniofacial patterns, such as Class II and hyperdivergency, might not be associated with adenoid hypertrophy.
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Paral, V., K. Witter, and Z. Tonar. "Microscopic examination of ground sections – a simple method for distinguishing between bone and antler?" International Journal of Osteoarchaeology 17, no. 6 (2007): 627–34. http://dx.doi.org/10.1002/oa.912.
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Redfern, Rebecca. "A regional examination of surgery and fracture treatment in Iron Age and Roman Britain." International Journal of Osteoarchaeology 20, no. 4 (2009): 443–71. http://dx.doi.org/10.1002/oa.1067.
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Shidlovskaya, Tetiana A., and Nadiya Ya Navalkivska. "Distortion product otoacoustic emissions among the patients suffering diabetes mellitus type II with hearing impairment." OTORHINOLARYNGOLOGY, no. 4-5(2) 2019 (March 12, 2020): 47–52. http://dx.doi.org/10.37219/2528-8253-2019-4-47.
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Topicality: Objective research methods of the auditory analyzer are of great importance in diagnosis sensorineural disorders of auditory function, treatment of such diseases and solving a number of expert questions. While diagnosis the damage of auditory system, especially the receptor part of the auditory analyzer the method of the caused OAE on the frequency distortion product (DPOAE) plays a significant role. Quite often at sensorineural hearing loss of different genesis is observed an affection of cochlea structures of the inner ear. Diabetes mellitus (DM) is one of the most acute medical and social problems. According to the latest data, there are 463 million adults with diabetes mellitus in the world; accounting for 9.3% of the world's total population, meaning that 1 among 11 people suffers from diabetes (IDF Diabetes Atlas 9th edition, 2019). Among patients with diabetes, according to various authors, there are disorders in the auditory analyzer. Purpose: to determine changes in the condition of the receptor part of auditory analyzer according to the OAE registration of the frequency of distortion products among patients with diabetes mellitus type II with impaired auditory function. Materials and methods: 17 patients with diabetes mellitus type II were examined, who, according to subjective audiometry, revealed impairments of auditory function of the I-II degree. The control group consisted of 15 healthy normal-hearing persons who did not report hearing impairment, had no elevated blood sugar levels. 32 persons were examined in total. The registration of the caused OAE at frequency of distortion product (DPOAE) was conducted on the analyzing system "Eclipse" "Interacoustics" (Denmark) at frequencies 1-6 kHz. Statistical processing of the obtained results was carried out according to the conventional methods of mathematical variation statistics using the STATISTICA software package. The average value of indicators was calculated - magnitude (M) and its error (+- m). The probability of changes and differences between the comparative values was estimated by the criterion for the reliability of the difference (t) according to the Student's table. Results and discussion: We have selected for the analysis patients with diabetes mellitus type II, who according to subjective audiometry revealed impaired auditory function. Patients also reported otologic complaints of hearing loss, periodic or persistent subjective ear noise. As a result of the OAE researches at frequency distortion products, the following data were obtained. A full adequate response of the otoacoustic emission across all frequency spectrums was reported in only 3 patients (9.4% of cases) on the one hand. The majority of the observed patients in whom the OAE was registered received a partially positive test (68.7%). In 7 patients (21.8%) the OAE response was not registered. The absence of OAE response or a partially positive registration in 90.6% of the observed patients indicated violation function of the cochlea in such patients. The DPOAE (response intensity) emission amplitude at all tested frequencies (1-6 kHz) in patients with diabetes mellitus type II was significantly (P<0.01) lower than the norm at all frequencies. Particularly pronounced such a decrease is in the area of 4 kHz, where the amplitude of the OAE response was 5.9±0.2 dB at a norm of 9.4±0.5 dB. Therefore, in patients with diabetes mellitus type II with hearing impairment, there are changes in the receptor part of the auditory analyzer, which is confirmed by the data of objective examination methods. The changes we have identified in the OAE indicators may express the affection of the receptor structures of the auditory analyzer among patients with diabetes mellitus type II with impaired auditory function. The information obtained on the OAE indicators provides the detection of early violations and the objective ascertainment of changes in the receptor part of the hearing analyzer in diabetes mellitus type II. Conclusions: 1. OAE data on the frequency of distortion products in patients with diabetes mellitus type II objectively confirm the presence of violations in the auditory receptor. 2. In patients with diabetes mellitus type II, the OAE amplitude at the frequency of distortion products is significantly lower than normal at all tested frequencies (1-6 kHz). Particularly pronounced such a decrease is in the area of 4 kHz, where the amplitude of the OAE response was 5.9±0.2 dB at a norm of 9.4±0.5 dB. 3. The conducted researches prove the expediency of examination by the method of registration of OAE of patients with diabetes mellitus type II, since it promotes the early detection of violation in the receptor structures of the auditory analyzer in such patients. 4. The use of the method of recording otoacoustic emissions in the examination of patients with type II diabetes is important for the objectification of early signs of sensorineural hearing impairment in this contingent.