Relevant bibliographies by topics / Excipiente / Dissertations / Theses
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Dissertations / Theses on the topic 'Excipiente'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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1

Pinto, Mônia Aparecida Lemos. "Estudos termoanalíticos da carbamazepina: hidratação/desidratação, decomposição térmica e interações com excipientes empregados em formulações farmacêuticas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-01112012-144158/.

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A carbamazepina (5H-dibenz[b, f]azepina-5-carboxamida) é um anticonvulsivante frequentemente utilizado no Brasil e em vários países. Ela apresenta quatro formas polimórficas e um di-hidratado, sendo ativa a Forma III. Entretanto, essa forma é altamente higroscópica podendo converter-se ao di-hidratado, menos ativo biologicamente. Nesse trabalho propõem-se avaliar o comportamento térmico da forma hidratada, visando à recuperação da forma ativa, por aquecimento. Para tanto, foi feito um estudo do comportamento térmico por TG/DTG-DTA e DSC em atmosfera dinâmica de ar e nitrogênio que evidenciou u
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2

Sarrate, Arjona Rocío. "Obtención por atomización y evaluación de agregados esféricos. Un nuevo excipiente co-procesado para compresión directa." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/404879.

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La aparición de los excipientes co-procesados se debe principalmente a la creciente apreciación del rol que desempeñan los excipientes en los comprimidos y a la mayor tendencia a su fabricación, especialmente por compresión directa, por las ventajas que aporta, tanto económicas como de proceso. Los excipientes co-procesados son combinaciones de dos o más excipientes establecidos que, a nivel particular son diseñados para modificar físicamente alguna de sus propiedades de una forma inalcanzable por la mezcla física simple, sin realizar cambio químico significativo. En este estudio se ha desa
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Viscasillas, Clerch Anna. "Aportación al diseño de un nuevo excipiente tipo "coprocessed products" para compresión directa." Doctoral thesis, Universitat de Barcelona, 2008. http://hdl.handle.net/10803/1616.

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El objetivo del presente trabajo es el diseño de un excipiente tecnoprocesado para compresión directa exento de lactosa en razón del handicap que supone, actualmente, su presencia en la mayoría de formulaciones de comprimidos. Excipiente que además presente una disgregación rápida que permita la vehiculación de fármacos tipo antiinflamatorios, analgésicos y antihipertensivos que requieren una rápida liberación con objeto de que esta fase del LADME no constituya una limitación para la consecución de una rápida acción terapéutica a nivel sistémico.<br/><br/>La tecnología de la compresión directa
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4

Recife, Ana Cristina Diniz [UNESP]. "Amido retrogradado como excipiente de comprimidos para liberação controlada de fármacos: obtenção e caracterização." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/122089.

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Made available in DSpace on 2015-04-09T12:28:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-06-27Bitstream added on 2015-04-09T12:47:38Z : No. of bitstreams: 1 000819760.pdf: 806612 bytes, checksum: f7007519ecbe89b8e5fa6a29ef981076 (MD5)<br>As matrizes hidrofílicas destacam-se como sistemas sólidos para a liberação controlada de fármacos destinados à via oral de administração de medicamentos, devido à relativa facilidade de processamento, possibilidade de incorporação de elevadas doses de fármaco e obtenção de perfis de liberação reprodutíveis. O amido resistente tipo 3 (AR3) e a
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Recife, Ana Cristina Diniz. "Amido retrogradado como excipiente de comprimidos para liberação controlada de fármacos: obtenção e caracterização /." Araraquara, 2007. http://hdl.handle.net/11449/122089.

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Orientador: Raul Cesar Evangelista<br>Coorientador: Beatriz Stringhetti Ferreira Cury<br>Banca: Marco Vinícius Chaud<br>Banca: Ana Dóris de Castro<br>Resumo: As matrizes hidrofílicas destacam-se como sistemas sólidos para a liberação controlada de fármacos destinados à via oral de administração de medicamentos, devido à relativa facilidade de processamento, possibilidade de incorporação de elevadas doses de fármaco e obtenção de perfis de liberação reprodutíveis. O amido resistente tipo 3 (AR3) e a pectina (P) são polímeros resistentes à ação das enzimas digestivas, sendo seletivamente degrada
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6

Daudt, Renata Moschini. "Estudo das propriedades do amido de pinhão visando a sua utilização como excipiente farmacêutico." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/56595.

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O amido é um dos polímeros naturais mais aplicados na indústria farmacêutica por sua versatilidade, disponibilidade e por ser um produto renovável. O pinhão é a semente da Araucaria angustifolia, a espécie de conífera nativa do Brasil mais importante economicamente, e é uma boa fonte de amido (aproximadamente 36 % em base úmida). A criação de novos usos para o amido de pinhão pode contribuir na preservação desta espécie pela utilização de um produto que geralmente sobra ao final da safra e, muitas vezes, é utilizado para alimentação animal. O presente trabalho teve por objetivo caracterizar um
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7

Cano, Casas Francesc. "Aportaciones al desarrollo preclínico de un medicamento oncológico infantil con excipiente o soporte textil." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2020. http://hdl.handle.net/10803/671788.

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The world of technical textiles is present every day in more sectors. In the work presented, a new facet of textile materials has been shown, textiles as a drug excipient and functional matrix. It is known that electro-spinning technology has opened up a range of possibilities in the field of medical textiles. However, the environment and the requirements of the pharmaceutical sector make the implementation of any new product a long and expensive job. This work is part of a project to develop a new medicine for both adult and paediatric cancer use. The drug that is developed uses as excipi
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8

Guimarães, Thiago Frances. "High shear melt granulation como alternativa de processo para granulação de artesunato." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-13122016-093419/.

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A modernização dos equipamentos de granulação por via úmida permitiu o desenvolvimento de diversas técnicas a partir do método tradicional. Dentre as técnicas desenvolvidas, a granulação por solidificação de materiais fundidos (GSMF) elimina o uso de solventes e diminui o tempo de processo. O presente trabalho teve por objetivo estudar o processo de granulação por solidificação de materiais fundidos usando um misturador/granulador do tipo high-shear (HSMG) e avaliar a influência das variáveis do processo nas características farmacotécnicas dos granulados e comprimidos obtidos. O artesunato foi
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9

Silva, Paulo César Dantas da. "Estudo termoanalítico de compatibilidade fármaco-excipiente e de estabilidade entre ácido lipóico e adjuvantes tecnológicos." Universidade Estadual da Paraíba, 2014. http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2371.

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Submitted by Jean Medeiros (jeanletras@uepb.edu.br) on 2016-03-17T14:38:05Z No. of bitstreams: 1 PDF - Paulo César Dantas da Silva.pdf: 4220175 bytes, checksum: 9d3262dd496783ccaaf630b5db5ea202 (MD5)<br>Approved for entry into archive by Secta BC (secta.csu.bc@uepb.edu.br) on 2016-07-22T15:00:23Z (GMT) No. of bitstreams: 1 PDF - Paulo César Dantas da Silva.pdf: 4220175 bytes, checksum: 9d3262dd496783ccaaf630b5db5ea202 (MD5)<br>Approved for entry into archive by Secta BC (secta.csu.bc@uepb.edu.br) on 2016-07-22T15:00:33Z (GMT) No. of bitstreams: 1 PDF - Paulo César Dantas da Silva.pdf: 422017
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Soares, Daiane dos Santos. "Avalia??o da argila atapulgita para potencial uso como excipiente farmac?utico em formas s?lidas." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13492.

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Made available in DSpace on 2014-12-17T14:16:34Z (GMT). No. of bitstreams: 1 DaianeSS_DISSERT.pdf: 2054024 bytes, checksum: bee46a4b535270b61e0c79e3911040aa (MD5) Previous issue date: 2013-05-22<br>Clays are natural materials that have great potential for use as excipients for solid dosage forms. Palygorskite is a type of clay that has hydrophilic properties as well as a large surface area, which could contribute to the dissolution of drugs. Thus, the present study aims to evaluate the use of palygorskite clay, from Piaui (Northeast region of Brazil), as a pharmaceutical excipient for solid
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11

Alves, Ricardo. "Estudo termoanalítico e de compatibilidade fármaco-excipiente de rifampicina e alguns medicamentos utilizados na terapêutica da tuberculose." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-31032008-162730/.

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Este trabalho teve por objetivo aplicar a análise térmica e outras técnicas físico-químicas e analíticas ao desenvolvimento e controle de qualidade de fármacos e medicamentos para tratamento de tuberculose, em especial a rifampicina. A calorimetria exploratória diferencial (DSC), termogravimetria/termogravimetria derivada (TG/DTG), análise elementar, espectrometria de absorção na região do infravermelho (IV) e difratometria de raios X (DRX) foram as principais ferramentas utilizadas. Estas técnicas permitiram: avaliar a estabilidade térmica e o processo de decomposição térmica da rifampicina e
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12

Benabbas, Rihab. "Valorisation d'un matériau bio-sourcé à usage pharmaceutique : étude de l'acide alginique et de sa fonctionnalité comme nouvel excipient pour compression directe." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTG011.

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L’acide alginique et les alginates sont des polysaccharides biosourcés, dont la biocompatibilité, la biodégradabilité et la non-toxicité en font des matières premières largement utilisées dans le domaine médical.La présente étude s’est attachée à la valorisation et à l’analyse des performances fonctionnelles de l’acide alginique pour un usage pharmaceutique comme excipient de nouvel intérêt dans la formulation des comprimés pharmaceutiques et notamment ceux élaborés par le procédé de compression directe.Quatre axes de recherche ont guidé le déroulement de ce travail :1- L’étude de l’acide algi
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13

Neto, Helio Salvio. "Estudo de compatibilidade fármaco/excipiente e de estabilidade do prednicarbato por meio de técnicas termoanalíticas, e encapsulação do fármaco em sílica mesoporosa do tipo SBA-15." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-22042010-112457/.

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Nos últimos 30 anos, a incidência da dermatite atópica aumentou de 4 para 12% em toda população mundial, acarretando um aumento significativo nos custos envolvidos no seu tratamento, tanto para as famílias, quanto para os sistemas de saúde. Para a dermatite atópica que ocorre de maneira suave à moderada, os corticosteróides de uso tópico são usualmente utilizados. Dentre eles, o prednicarbato se destaca por ser um potente agente antiinflamatório e por ter um baixo potencial em causar atrofia de pele. Neste trabalho, inúmeras técnicas de análise e de caracterização, em especial as técnicas de D
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14

Caricati, Aline Tojeira Prestia. "Estratégias do processo para a conservação da potência da vacina rábica de uso veterinário por liofilização." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-26062012-115337/.

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Uma vacina liofilizada, em comparação a uma líquida, possui inúmeras vantagens, tais como: a melhora na estabilidade do produto às variações de temperatura aumentando sua vida de prateleira, possibilitando uma melhor logística do produto aos locais onde o acesso à rede refrigerada é difícil. O presente trabalho visou investigar as estratégias do processo para a conservação da potência da vacina rábica de uso veterinário por liofilização. O material testado foi a vacina rábica inativada (VRI). Ao total foram testados 13 excipientes com três concentrações diferentes. O processo de triagem utiliz
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Gallo, Renata Cristina. "Estudos termoanalíticos do antihipertensivo β- bloqueador carvedilol: comportamento térmico, interação com excipientes e polimorfismo." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-17042015-095846/.

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Estudos sobre o comportamento térmico, de interação fármaco-excipiente e sobre polimorfismo do Carvedilol (1-(9H-Carbazol-4-iloxi)-3-[[2-(2-metoxifenoxi)etil]amino]-2-propanol), um fármaco da família dos &beta;-bloqueadores, frequentemente utilizado no tratamento de doenças do coração e isquemias foram desenvolvidos, usando as técnicas termoanalíticas termogravimetria (TG), termogravimetria derivada (DTG), análise térmica diferencial (DTA) e calorimetria exploratória diferencial (DSC), além de técnicas complementares como espectroscopia vibracional na região do infravermelho com transformada d
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16

Brouillet, Fabien. "Contribution au développement de matrices hydrophiles à base de carboxyméthylamidon sodique à haute teneur en amylose : élaboration et évaluation des performances." Thèse, Montpellier 1, 2007. http://hdl.handle.net/1866/6648.

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17

Chaheen, Mohammad. "Evaluation de la chitine comme nouvelle source d’excipients multifonctionnels pour la formulation et la mise en œuvre par compression directe de comprimés à désintégration rapide." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTG018.

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La demande actuelle croissante d’excipients multifonctionnels par les laboratoires pharmaceutiques, amène les fabricants de matières premières à développer de nouveaux matériaux pouvant répondre à ces critères de performance. Parmi les différents procédés disponibles pour de telles productions, les techniques de co-traitement sont les plus sollicitées. Considérant l’évaluation de la fonctionnalité de différents excipients désintégrants, l’objectif de cette thèse a été de développer un tel excipient, original, économiquement intéressant et pouvant être utilisé dans la fabrication de comprimés p
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Barra, Jérôme. "Intérêts des paramètres de solubilité et des énergies de surface dans la formulation des formes pharmaceutiques solides." Lyon 1, 1999. http://www.theses.fr/1999LYO1T177.

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19

Yu, Shen. "Roll compaction of pharmaceutical excipients." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4137/.

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Roll compaction is commonly used as a dry granulation technique in the pharmaceutical industry to produce tablets for formulations sensitive to heat and moisture. This thesis reports systematic studies on the behavior of pharmaceutical excipients in associated unit operations (i.e. roll compaction, milling, tabletting), as well as their correlations. Roll compaction experiments were carried out using an instrumented roll compactor with a gravity feeding system. The influence of the process parameters, material properties and powder conditioning were investigated Ribbons produced in roll compac
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20

Soulairol, Ian. "Etude des phénomènes liés à la conception de mini-comprimés orodispersibles par compression directe." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT115/document.

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La possibilité d’administrer des formes sèches orales est encore de nos jours un enjeu dans certaines spécialités médicales telles que la pédiatrie, la neurologie ou la gériatrie. Les mini-comprimés orodispersibles présentent un intérêt majeur pour répondre à cette problématique.L’objectif de ce travail est d’étudier les différents phénomènes qui régissent la conception de cette forme pharmaceutique par compression directe.Trois axes de recherche ont été fixés pour la réalisation de ce travail : - Premièrement, étudier les paramètres de formulation et de fabrication des mini-comprimés orodispe
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21

Ashiru, Diane A. I. "Modulating Intestinal Absorption Using Pharmaceutical Excipients." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509950.

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22

Dumoulin, Yves. "L'amylose réticulé, un nouvel excipient pharmaceutique." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0020/NQ43714.pdf.

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23

Mueannoom, W. "Engineering excipient-free particles for inhalation." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1425624/.

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The size of inhalable particles should be approximately between 1-5 µm to be delivered to the lower respiratory tract. However, there are some disadvantages of the powders having such a small particle size, such as the difficulty of aerosolisation due to their intrinsic cohesiveness. Generating porous particles is a way of increasing the physical size of particles to enable effective aerosolisation but remain sufficiently small to reach the lower airways. A modified Hewlett-Packard thermal inkjet printer (TIJ) and airbrush (Model 200-3, USA) were used to engineer drug solutions of the inhalabl
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Ebba, Frédéric Emery. "Influence de la lubrification sur la relaxation de contrainte." Aix-Marseille 2, 2002. http://theses.univ-amu.fr.lama.univ-amu.fr/2002AIX22950.pdf.

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Buggins, Talia Rae. "Effects of pharmaceutical excipients on drug disposition." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55658/.

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This thesis investigates the potential of some commonly used pharmaceutical excipients to alter drug pharmacokinetics. In breath test studies, 3.2ml/kg DMSO prolonged the half-life of 14C-aminopyrine, -erythromycin and -NDMA, indicating in vivo inhibition of metabolism by CYP3A (erythromycin), CYP2E1 (NDMA) and the variety of enzymes that metabolise aminopyrine (CYP 2C11, 2C12, 2B1 and 2B2). However, no effects were apparent at doses typically used in pre-clinical formulations. Aminopyrine and erythromycin breath tests were not affected by propylene glycol (PG) or Solutol HS15, however PG did
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Beneke, CE, AM Viljoen, and JH Hamman. "Polymeric Plant-derived Excipients in Drug Delivery." Molecules, 2009. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001726.

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Abstract: Drug dosage forms contain many components in addition to the active pharmaceutical ingredient(s) to assist in the manufacturing process as well as to optimise drug delivery. Due to advances in drug delivery technology, excipients are currently included in novel dosage forms to fulfil specific functions and in some cases they directly or indirectly influence the extent and/or rate of drug release and absorption. Since plant polysaccharides comply with many requirements expected of pharmaceutical excipients such as non-toxicity, stability, availability and renewability they are extens
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Garr, Joseph Sunday Mola. "Compaction characteristics of direct compression tableting excipients." Thesis, Liverpool John Moores University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261399.

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Pollard, John. "The biological effects of commonly used excipients." Thesis, Aston University, 2017. http://publications.aston.ac.uk/31741/.

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Efflux transporters such as ABCB1 (P-gp) and ABCC2 (MRP-2) expressed on the apical membranes of epithelial cells of the intestine represent a formidable barrier for the effective delivery of a plethora of pharmaceutically relevant compounds. Excipients have attracted significant interest in their role as efflux protein inhibitors. To this end, the aim of this study was to examine the biological effects of commonly used excipients, and utilise this information in the design and manufacture of orally disintegrating tablets (ODT) using a design of experiments (DoE) approach. The ‘gold standard’ m
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Patel, Chaitanya I. "Design and characterization of direct compression excipients." Thesis, University of Bath, 1986. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370466.

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Elgaied-Lamouchi, Dhouha. "Découverte de nouveaux excipients pharmaceutiques à base d'amidons modifiés pour une libération prolongée d'une substance active." Thesis, Lille, 2020. https://pepite-depot.univ-lille.fr/.

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Les comprimés matriciels hydrophiles sont fréquemment utilisés pour contrôler la libération d’actif dans les formes galéniques à usage oral. Les amidons représentent un choix intéressant pour cette application. En effet, ce sont des matériaux biocompatibles, biodégradables et disponibles à partir de différentes sources végétales. En plus des amidons natifs, les amidons modifiés (AM) ont été beaucoup étudiés pour la formulation des comprimés matriciels à libération prolongée. Les modifications physico-chimiques peuvent être ajustées de manière à correspondre aux propriétés souhaitées pour une a
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Gilardi-Lorenz, Francine Isabelle. "Analytical characterisation of the excipient Polysorbate 80 /." Zürich : ETH, 2006. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=16723.

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Nep, E. I. "Grewia polysaccharide gum as a pharmaceutical excipient." Thesis, Aston University, 2010. http://publications.aston.ac.uk/10310/.

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Grewia gum is obtained from the inner stem bark of the edible plant Grewia mollis Juss (Fam. Tiliaceae) which grows widely in the middle belt region of Nigeria, and is also cultivated. The dried and pulverised inner stem bark is used as a thickening agent in some food delicacies in that region of the country. This ability of the material to increase solution viscosity has generated a lot of interest and is the catalysing momentum for this research. Such materials have been used as stabilizers or suspending agents in cosmetics, foods and liquid medications, and as mucoadhesives and controlled r
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Lucero, Borja Diego Sebastián. "Solubility and Dissolution Rate of Active Pharmaceutical Ingredients: Dissolution Media and Effect of Enhancers." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/671762.

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The present doctoral thesis is focused on the effect of pH, enhancers and biorelevant media in the Solubility and the Dissolution Rates of some selected acidic active pharmaceutical ingredients (API). Because of the effect of these physicochemical parameters in the bioavailability of drugs and their pharmacological action, deepen the knowledge on the factors affecting the dissolution properties is of paramount importance in the drug development process. Solubility and dissolution rates are examined in different aqueous solutions and buffering systems, accounting for the pH values of main inte
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TERRA, Gleysson de Paula. "Estudos do efeito estabilizante dos excipientes em pancreatina." Universidade Federal de Alfenas, 2015. https://bdtd.unifal-mg.edu.br:8443/handle/tede/772.

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A pancreatina é um produto biotecnológico que contém um complexo enzimático obtido do pâncreas suíno, constituído principalmente pela amilase, lipase e protease. A literatura ainda apresenta poucos dados relacionados à estabilidade da pancreatina em formulações. Desta forma, foram realizados experimentos relativos à estabilidade usando o medicamento comercial Creon 10.000 e também o padrão de pancreatina puro e suas misturas binárias empregando 6 excipientes na proporção de 1:1 (m/m). Para isso, as amostras foram armazenadas durante 1, 3 e 6 meses em câmara de estabilidade a 40 ± 1°C e 75 ± 5%
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Dogbe, Selasi Cudjoe. "Predictive milling of active pharmaceutical ingredients and excipients." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/17937/.

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Spiral jet milling is a size reduction process used in various industries, ranging from paints to food and pharmaceuticals. It has great benefit in the pharmaceutical industry due to its ability to reduce particulate solids to micron sizes and narrow size distributions. Despite its heavy usage, the underlying size reduction mechanism of the mill is not well understood. However it is generally known that the milling behaviour is dependent on the grinding conditions of the mill, as well as the materials physical and mechanical properties. The system is also very energy inefficient. In this work
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Figueiredo, Laysa Pires de. "Análise de excipientes em comprimidos de fármacos comercializados." reponame:Repositório Institucional da UFABC, 2012.

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37

Doherty, C. "Microenvironmental role of pharmaceutical excipients in drug dissolution control." Thesis, University of Bradford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374915.

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38

Blundell, L. P. "Characterisation and compaction parameters of directly compressible tablet excipients." Thesis, Cardiff University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356740.

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39

Mai, Yang. "Sex-specific modulation of drug bioavailability with pharmaceutical excipients." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10044027/.

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The biopharmaceutics classification system (BCS) is a framework for classifying drug substances based on their aqueous solubility and permeability across a biological membrane. It is possible for individuals to request a waiver of in vivo bioequivalence (BE) studies for immediate-release solid oral dosage forms. Nowadays, the Food and Drug Administration allows the biowaiver for BCS Class I and Class III drugs. However, the findings in this thesis call attention to the unearthed loopholes in this regulation, given that formerly considered “inert” pharmaceutical excipients have shown unexpected
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40

Bond, Laura. "Macro- and nano-scale characterisation of drug-excipient incompatibility." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416285.

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41

Li, Hiu-yu, and 李曉瑜. "The effect of excipients on the stability of bisacody1 suppositories." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193524.

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42

Lerdkanchanaporn, Supaporn. "Application of thermal analysis to ibuprofen and associated formulation excipients." Thesis, University of Hertfordshire, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302281.

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43

Gaisford, Simon. "Kinetic and thermodynamic investigation of a series of pharmaceutical excipients." Thesis, University of Kent, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242881.

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44

Mansa, Rachel Fran. "Roll compaction of pharmaceutical excipients and prediction using intelligent software." Thesis, University of Birmingham, 2007. http://etheses.bham.ac.uk//id/eprint/5406/.

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Roll compaction is a dry granulation method. In the pharmaceutical industry it assists in binding tablet ingredients together to form a larger mass. This is conducted to ease subsequent processing, decrease dust, improve flowability, improve material distribution, more suitable for moisture and heat sensitive materials than wet granulation methods, minimises operating space and suited for a continuous manufacturing set-up. In pharmaceutical roll compaction various types of powder material mixtures are compacted into ribbon that are subsequently milled and tableted. The aim of this research is
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45

Zheng, Chen. "The use of excipients to stabilise pressurised metered dose inhalers." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/113171/.

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This thesis concerns investigations of novel pressurised metered dose inhaler (pMDI) formulations containing tiotropium (Tio) in association with a secondary particulate (SP). A number of formulation and hardware variables were studied using in vitro methods to determine their influence on the performance of these novel formulations. Initial studies indicated that Tio was practically insoluble in HFA propellants and its solubility was not increased under raised moisture levels during long-term stability tests. Formulations with L-leucine (Leu) or lactose (Lac) as SP’s were investigated in Tio:
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46

Monteiro, Ana Sofia da Costa Libânio. "Segurança dos excipientes utilizados nos medicamentos genéricos numa população pediátrica." Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1642.

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Este relatório de estágio é constituído por três vertentes, sendo o capítulo I referente ao projeto de investigação, o capítulo II correspondente ao estágio em Farmácia Comunitária e o capítulo III respeitante ao estágio em Farmácia Hospitalar. No capítulo I pretende-se avaliar a segurança dos excipientes utilizados nos medicamentos genéricos numa população pediátrica. Os medicamentos genéricos podem diferir do medicamento de referência em termos dos excipientes presentes nas suas formulações. A informação sobre a exposição da população pediátrica aos excipientes é escassa e dispersa, não ex
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47

Brohede, Ulrika. "Drug Diffusion and Nano Excipient Formation Studied by Electrodynamic Methods." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7818.

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48

Mohd, Zaki Hamizah. "Spectroscopy surface analysis of paracetamol and paracetamol and excipient systems." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/spectroscopy-surface-analysis-of-paracetamol-and-paracetamol-and-excipient-systems(2f50af69-fb35-487b-8065-46aa3c86f96c).html.

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A detailed, fundamental understanding of the surface properties of molecular crystals and their interaction with adsorbing molecules (e.g. excipients) is important for tailoring the stability of formulations and the bioavailability of Active Pharmaceutical Ingredient (APIs). Few fundamental experimental studies with surface sensitive probes have been carried out for organic molecular crystals. X-ray photoelectron spectroscopy (XPS) is an established surface analysis method in the fields of adsorption, catalysis and surface chemistry of inorganic crystals. It has high surface sensitivity, probi
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49

Galley, Olivier. "Étude des caractéristiques de compression d'excipients pharmaceutiques et d'hydroxyapatites non-stoechiométriques : proposition de nouveaux modèles de densification à faibles contraintes." Toulouse, INPT, 1999. http://www.theses.fr/1999INPT001C.

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Ce travail concerne l'etude en compression de huit excipients commerciaux (deux celluloses : avicel ph101 et ph102 ; deux lactoses : pharma et fast flo ; trois phosphates de calcium : tritab, ditab et encompress ; et un amidon : sta-rx 1500), ainsi que de cinq hydroxyapatites synthetisees par la technique de precipitation. La diffraction des rayons x, la surface specifique, la repartition granulometrique, la microscopie electronique a balayage et les tests pharmacotechniques sont quelques unes des techniques utilisees pour caracteriser ces materiaux pulverulents. Une analyse en relaxation de f
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Vilela, Ana. "Influence d'une action mécanique en voie sèche sur l'amélioration et l'association d'actifs pharmaceutiques et d'excipients : application de l'hybridizer nara." Paris 11, 2005. http://www.theses.fr/2005PA114839.

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D'un grand intérêt industriel, la modification de surface des particules par enrobage s'obtient en voie sèche par différents procédés qui génèrent des forces mécaniques conduisant à des interactions physico-chimiques entre particules. Dans ce travail, deux extraits végétaux (prêle et harpagophyton) ont été enrobés avec du stéarate de magnésium et de l'Aérosil®R972 pour diminuer leur hygroscopicité, en utilisant un Hybridizer. L'enrobage des particules est visualisé au MEBE. Les effets du traitement sur l'hygroscopicité sont évalués (DVS, comparaison des produits au MEBE sous atmosphère humide)
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