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Journal articles on the topic 'Excision margins'

Author: Grafiati

Published: 1 June 2024

Last updated: 31 July 2025

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1

Subhas, Gokulakkrishna, Asha J. Shah, Aditya Gupta, et al. "Review of Third and Fourth Re-Excision for Narrow or Positive Margins of Invasive and Intraductal Carcinoma." International Surgery 96, no. 1 (2011): 18–20. http://dx.doi.org/10.9738/1340.1.

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Abstract The trend in breast surgery has shifted toward breast conservation. We reviewed our third and fourth breast re-excision cases, with an analysis of various factors used in making this decision. A retrospective analysis identified 585 patients who underwent re-excision surgery for positive or close margins of invasive carcinoma or ductal carcinoma in situ (DCIS). Of these patients 75 (13%) and 17 (3%) underwent third and fourth re-excisions, respectively. The indication for a third re-excision was the presence of positive and/or close (≤1 mm) margins for invasive carcinoma or DCIS in 72

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2

Ozmen, V., S. Ozkan Gurdal, M. Muslumanoglu, et al. "Predictive factor for residual tumor after lumpectomy for close margins." Journal of Clinical Oncology 27, no. 15_suppl (2009): e11538-e11538. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e11538.

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e11538 Background: It is critical to obtain clear margins to minimize local recurrence after breast conserving surgery(BCS). When re-excisions are performed, there is often no residual disease in the new specimen, calling into question the need for re-excision(s) or mastectomy. The aim of the present study was to identify factors predicting a histologically positive re-excision specimen. Methods: Our prospective breast cancer database was queried for all invasive breast cancer patients who underwent a re-excision lumpectomy for either close or positive margins after an attempt at BCS. Close ma

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3

Semple, Harriet K., and Marc J. Langbart. "Margin of error: accuracy of estimated excision margins by surgical experience." Australasian Journal of Plastic Surgery 5, no. 1 (2022): 13–16. http://dx.doi.org/10.34239/ajops.v5n1.257.

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Guidelines for recommended margins for common lesions are well documented. While it is recommended that all margins be measured prior to excision, time pressures, lack of equipment or clinician confidence may result in margins that are estimated rather than formally measured. This increases the risk of involved margins and need for re-excision to prevent recurrence. We reviewed the estimated margins of common excisions and compared these between groups of different surgical experience. We found that while accuracy generally improves with surgical experience, margins are largely underestimated

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O’Connell, L., S. Walsh, D. Evoy, et al. "The approach to an isolated close anterior margin in breast conserving surgery." Annals of The Royal College of Surgeons of England 101, no. 4 (2019): 268–72. http://dx.doi.org/10.1308/rcsann.2019.0017.

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Introduction Although close radial margins after breast-conserving surgery routinely undergo re-excision, appropriate management of patients with close anterior margins remains a topic of controversy. An increasing body of literature suggests that re-excision of close anterior margins yields low rates of residual malignancy and may only be necessary in selected patients. The aim of this study was to examine the management of close anterior margins after breast conserving surgery in a single institution and to analyse the rate of residual disease in re-excised anterior margins. Methods All pati

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Ghosh, S., S. Duvvi, P. Goodyear, E. Reddy, and A. Kumar. "Evaluation of surgeons' marking of excision margins for superficial facial skin cancer lesions." Journal of Laryngology & Otology 123, no. 2 (2008): 195–98. http://dx.doi.org/10.1017/s0022215108002612.

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AbstractIntroduction:We established a series of exercises that evaluated surgeons' marking of excision margins, and we sought to identify factors influencing such marking.Methods:Twenty-four participants were asked to draw preset margins (3, 4, 5, 8 or 10 mm) on a series of life-size images representing noncosmetically and cosmetically sensitive facial sites, and also to draw circles of set diameters (3, 5 and 8 mm) on white paper. Margins were measured with vernier callipers calibrated to 0.05 mm.Results:In the small margin (3 mm) and noncosmetically sensitive exercises, the mean margins draw

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Adkison, Michael, Andrew Armenta, Frank Winsett, and Richard Wagner. "Review of Tumor Margins for Lentigo Maligna with Staged Surgical Excision and Permanent Section en face Processing." SKIN The Journal of Cutaneous Medicine 8, no. 4 (2024): 1672–80. http://dx.doi.org/10.25251/skin.8.4.5.

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Background: The optimal surgical margins required for the excision of lentigo maligna remains a topic of debate. Recent literature suggests that wider margins are warranted. Objective: Comparison of lentigo maligna margin sizes and clearance rates from a single center to existing literature. Methods: A retrospective analysis of primary and recurrent lentigo maligna treated by staged excision with complete circumferential and deep margin assessment between 2011 and 2023 at a single institution was conducted. The percentage of tumors with clear margins after the initial excision with 5 mm margin

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7

Sebastian, Mary L., Alice Marie Police, Stephanie Akbari, and Beth Anglin. "Combined experience at three breast centers with routine use of an intraoperative margin assessment device including comparison to historical re-excision rates." Journal of Clinical Oncology 32, no. 26_suppl (2014): 79. http://dx.doi.org/10.1200/jco.2014.32.26_suppl.79.

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79 Background: Historically there has been a high rate of surgical interventions to obtain clear margins for breast cancer patients undergoing breast conserving local therapy. This study is the first compellation of data among three breast centers to assess the impact of an intraoperative margin assessment tool (MarginProbe) on re-excision rates. This device has been approved for clinical use in the United States since 2013. We present groups of consecutive patients in each of these breast centers – before and after the implementation of routine intraoperative use of the margin assessment devi

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Lupu, Mihai, Vlad Mihai Voiculescu, Ana Caruntu, Tiberiu Tebeica, and Constantin Caruntu. "Preoperative Evaluation through Dermoscopy and Reflectance Confocal Microscopy of the Lateral Excision Margins for Primary Basal Cell Carcinoma." Diagnostics 11, no. 1 (2021): 120. http://dx.doi.org/10.3390/diagnostics11010120.

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Complete removal of malignant skin lesions with minimal impact on the aesthetic and functional aspects is the ideal of every dermatologic surgeon. Incomplete surgical excisions and tumor recurrences of basal cell carcinomas (BCC) commonly occur due to the subclinical extension of tumor lateral margins. Presently, the lateral excision margins for BCC cannot be objectively assessed preoperatively, dermoscopy proving to be relatively inefficient in this respect. The question is whether BCC lateral excision margins can be precisely determined preoperatively through the use of complementary non-inv

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Martin, Luke, Miguel S. Cabalag, Anand Ramakrishnan, and Andrew Martin. "Management of close/positive margins in cutaneous squamous cell carcinoma of the head and neck: a systematised review." Australasian Journal of Plastic Surgery 7, no. 2 (2024): 1–13. http://dx.doi.org/10.34239/ajops.88849.

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Introduction: The authors reviewed close/positive margins in cutaneous squamous cell carcinoma of the head and neck, ensuing recurrence, regional or systemic metastasis, mortality and follow-up management. Methods: The design was a systematised review from January 2000 to July 2021. The MEDLINE database was searched with 15 articles out of 3104 meeting the inclusion criteria. Pertinent references underpinning the National Comprehensive Cancer Network’s Squamous Cell Skin Cancer Guidelines Version 2.2022 were reviewed. Results: Overall, there were 13,671 cutaneous squamous cell carcinoma lesion

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Schnabel, Freya Ruth, Shira Schwartz, Deirdre Kiely, and Jennifer Chun. "Improving breast-conserving surgery: A focus on margins." Journal of Clinical Oncology 31, no. 31_suppl (2013): 127. http://dx.doi.org/10.1200/jco.2013.31.31_suppl.127.

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127 Background: Inadequate lumpectomy margins are associated with an increased risk of ipsilateral recurrence in patients undergoing breast conserving surgery for cancer. Multiple procedures are often required to achieve acceptable margins, increasing the burden to the patient and the health care system, and potentially delaying other adjuvant treatments. A novel device for intraoperative assessment of lumpectomy margins (MarginProbe) has been associated with a 25% reduction in the rate of positive margins at the conclusion of primary lumpectomy surgery. Our aim was to establish a baseline re-

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Zaiem, Fadi, Anna Numi, Mira Kheil, et al. "Abstract PO2-03-03: The Significance of Cavity Shave Margins in Breast Carcinoma on Margin Status and Re-excision Rates." Cancer Research 84, no. 9_Supplement (2024): PO2–03–03—PO2–03–03. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-03-03.

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Abstract Context: The comparative outcomes of breast conserving surgery (BCS) with and without cavity shave margins are not well established. We aim to evaluate the impact of each procedure on final margin status and rate of re-excision. Design: A total of 529 breast cancer cases from our institution between 2013-2015 were included. Demographic and clinicopathological data including procedure type, tumor type, grade, margins status, and re-excision rates were collected. H&E slides of positive margins (tumor on ink) were reviewed by two pathologists. Appropriate statistical analysis was per

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Klooz, Andrea, Terrence Kumar, and Jessica Maxwell. "Malignant phyllodes tumour of the breast with early recurrence in a young patient." BMJ Case Reports 17, no. 3 (2024): e258352. http://dx.doi.org/10.1136/bcr-2023-258352.

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A young woman in her 20s was found to have a left breast malignant phyllodes tumour by ultrasound-guided core needle biopsy, after identifying a palpable lump. She then underwent lumpectomy excision with >1 cm gross margins; however, final pathology demonstrated <1 cm margins at the superior margin. She then underwent re-excision of superior and medial margins to ensure at least a 1 cm margin. Biopsy tract was not excised at initial or re-excision surgery. Approximately 6 weeks after completion lumpectomy, the patient noted a new palpable mass near the previous biopsy site and underwent

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Bilden, Tylert, Katherine C. Benedict, Patrick W. Lamb, and Jaron Mcmullin. "Intraoperative Frozen Section Analysis for the Excision of Nonmelanoma Skin Cancer: A Single-Center Experience." American Surgeon 85, no. 12 (2019): 1397–401. http://dx.doi.org/10.1177/000313481908501236.

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Surgical resection of nonmelanoma skin cancer (NMSC) may be performed via Mohs micrographic surgery (MMS) or standard surgical excision with complete margin analysis. Whereas MMS may necessitate delayed reconstruction surgery, intraoperative frozen section analysis (IFSA) may be used to ensure clear surgical margins before proceeding with reconstruction. To achieve curative resection while optimizing aesthetic outcomes, surgeons may use surgical excision guided by IFSA to forego extensive or delayed reconstruction. Patients undergoing wide local excision for NMSC using IFSA from October 2008 t

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Raleigh, Matthew L., Mark M. Smith, and Kendall Taney. "Curative Intent Surgery of Oral Malignant Melanoma and Regional Lymph Node Biopsy Assessment in 25 Dogs: 2006–2017." Journal of Veterinary Dentistry 38, no. 4 (2021): 193–98. http://dx.doi.org/10.1177/08987564211072396.

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Medical records were searched for dogs that had received curative intent surgery for oral malignant melanoma and ipsilateral excisional regional lymph node biopsy. Twenty-seven dogs were operated on and 25 dogs of these dogs met the inclusion criteria of signalment, post-excision margin status, presence of metastasis for each biopsied lymphocentrum, survival time post-excision, presence of recurrence or metastasis at follow-up or at death/euthanasia, location of the primary tumor, and any postoperative adjuvant treatment. These 25 dogs had complete tumor excision with tumor-free margins and 19

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Medina Bueno, Gonzalo Arturo, Maria Eulalia Fernández-Montolí, Fatima Heydari, Jordi Ponce, Sara Tous, and Judith Peñafiel. "Impact of Excision Type, Cone Volume, and Dimensions on Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2–3." Life 14, no. 8 (2024): 968. http://dx.doi.org/10.3390/life14080968.

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The objective of this study was to evaluate the relationship between the excision type and the persistence/recurrence of CIN2–3. A total of 227 women with CIN2–3 who were treated with LLETZ were evaluated. The types of excision according to the IFCPC 2011, volume, cone dimensions, margins of resection, post-cone high-risk human papillomavirus (HR-HPV) status, and viral load were studied. The time to recurrence was assessed using Kaplan–Meier curves. Persistent/recurrent CIN2–3 was found in 12 cases (5.2%). Type 1 excision was performed in 107 patients, with 7 recurrences (6.5%); type 2 excisio

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Ross, M. "Margins of excision." Melanoma Research 3, no. 1 (1993): 9. http://dx.doi.org/10.1097/00008390-199303000-00020.

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17

Batsakis, John G. "Surgical Excision Margins." Advances in Anatomic Pathology 6, no. 3 (1999): 140–48. http://dx.doi.org/10.1097/00125480-199905000-00002.

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18

Kotwall, Cyrus, Mark Ranson, Anquonette Stiles, and Mary Sue Hamann. "Relationship between Initial Margin Status for Invasive Breast Cancer and Residual Carcinoma after Re-Excision." American Surgeon 73, no. 4 (2007): 337–43. http://dx.doi.org/10.1177/000313480707300405.

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Little data exists addressing the relationship between initial margin status in a specimen from an excisional biopsy and the presence of residual carcinoma in a subsequent specimen from lumpectomy or mastectomy. We sought to determine the relationship between initial margin status and the presence of residual invasive cancer, and to identify any relationship to other variables. This study was a retrospective review of pathology reports of 582 early-stage invasive duct carcinomas with open excisional biopsies. The initial specimen was classified into one of six margin categories: multiply focal

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19

Patterson, Ryan, Mitchell Guest, Mariam Shenouda, et al. "Predictors of residual disease after breast conservation surgery for ductal carcinoma in situ: A retrospective study." Journal of Cancer Research and Therapeutics 20, no. 3 (2023): 844–49. http://dx.doi.org/10.4103/jcrt.jcrt_2657_22.

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ABSTRACT Background: Breast-conserving therapy is the standard of care for ductal carcinoma in situ (DCIS). Debate on what constitutes a satisfactory margin persists. This study aimed to identify predictors of residual disease at re-excision. Methods: This is a population-based retrospective cohort study of women with DCIS who underwent a lumpectomy between 2007 and 2017 in Manitoba, with close (≤2 mm) or positive margins that led to re-excision. Results: The DCIS re-excision rate was 29.3% for 1001 patients. 63.2% of patients were found to have residual disease on re-excision. On univariable

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Paternostro, Chiara, Elmar A. Joura, Christina Ranftl, et al. "Rate of Involved Endocervical Margins According to High-Risk Human Papillomavirus Subtype and Transformation Zone Type in Specimens with Cone Length ≤ 10 mm versus > 10 mm—A Retrospective Analysis." Life 13, no. 8 (2023): 1775. http://dx.doi.org/10.3390/life13081775.

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The aim of this study was to evaluate the endocervical margin status according to transformation zone (TZ) and high-risk HPV (hr-HPV) subtype in specimens with cone length ≤ 10 mm versus > 10 mm to provide data for informed decision making and patients counseling especially for women wishing to conceive. In this retrospective cohort study, 854 patients who underwent large loop excision of the transformation zone during a nine-year period (2013–2021) for cervical disease were analyzed. The main outcome parameters were excision length, histological result, TZ type, HPV subtype and endocervica

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Attrill, Grace Heloise, Teresa A. Bailey, Trina Lum, et al. "Abstract 2221: Molecular analysis finds excision margin width predictive of recurrence in acral melanoma." Cancer Research 82, no. 12_Supplement (2022): 2221. http://dx.doi.org/10.1158/1538-7445.am2022-2221.

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Abstract Surgical excision with histologically clear margins results in cure of most melanoma patients. Involvement of the margins is associated with tumour recurrence and adverse outcomes. Determining whether or not the histological margins are involved by melanoma, particularly in situ melanoma, can be very difficult particularly in acral locations where insitu melanoma can be extremely subtle. This study sought to determine the proximity of acral melanoma in situ to the surgical excision margin using multiple methods including routine histopathological assessment, FISH (CCND1 amplification)

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Gupta, Aditya, Gokulakkrishna Subhas, Linda Dubay, et al. "Review of Re-Excision for Narrow or Positive Margins of Invasive and Intraductal Carcinoma." American Surgeon 76, no. 7 (2010): 731–34. http://dx.doi.org/10.1177/000313481007600729.

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The trend in breast surgery has shifted towards breast conservation. Re-excision rates for narrow or positive margins have been variable in published reports. A retrospective analysis of 3246 patients who underwent either a lumpectomy for a palpable mass or a needle localization biopsy between January 2003 and December 2007 was done. Five hundred and eighty-five patients underwent re-excision surgery for margins. The mean patient age was 59-years-old (range 25-93). Needle localization was used to guide initial excision in 372 of 585 patients (64%). Invasive carcinoma was seen in 402 (69%) pati

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Ito, Takamichi, Yumiko Kaku-Ito, Maiko Wada-Ohno, and Masutaka Furue. "Narrow-Margin Excision for Invasive Acral Melanoma: Is It Acceptable?" Journal of Clinical Medicine 9, no. 7 (2020): 2266. http://dx.doi.org/10.3390/jcm9072266.

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In this retrospective review of 100 patients with primary invasive acral melanoma, we examined whether narrow-margin excision is warranted for acral melanoma. Patients treated with surgical margins recommended by the National Comprehensive Cancer Network (R-group) were compared to those treated with narrow margins (N-group). A total of 65 patients underwent narrow-margin excision. Positive margin status or local recurrence rarely occurred regardless of the excision margins, whereas fatal events frequently occurred, particularly among the patients with T4 melanoma. The mortality rates of N- and

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Shirazi, Shahram, Hamed Hajiesmaeili, Muskaan Khosla, Saima Taj, Tapan Sircar, and Raghavan Vidya. "Comparison of Wire and Non-Wire Localisation Techniques in Breast Cancer Surgery: A Review of the Literature with Pooled Analysis." Medicina 59, no. 7 (2023): 1297. http://dx.doi.org/10.3390/medicina59071297.

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Background and Objectives: Wide local excision is a common procedure in the treatment of breast cancer. Wire-guided localisation (WGL) has been the gold standard for many years; however, several issues have been identified with this technique, and therefore, wire-free techniques have been developed. This scoping review synthesises the available literature comparing wire-guided localisation with the wire-free techniques used in breast-conserving cancer surgery. Materials and Methods: Multiple databases including Pubmed and MEDLINE were used to search articles between 1 January 2000 and 31 Decem

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Wanis, Morcos L., Jennifer A. Wong, Samuel Rodriguez, et al. "Rate of Re-excision after Breast-conserving Surgery for Invasive Lobular Carcinoma." American Surgeon 79, no. 10 (2013): 1119–22. http://dx.doi.org/10.1177/000313481307901034.

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Invasive lobular carcinoma (ILC) accounts for approximately 5 to 20 per cent of all breast cancers and is often multicentric. Despite pre- and intraoperative assessments to achieve negative margins, ILC is reported to be associated with higher rates of positive margin. This cross-sectional study examined patients with breast cancer treated at our institution from 2000 to 2010. The objective was to investigate the rate of re-excision resulting from positive or close margin (1 mm or less) in patients who underwent breast-conserving surgery (BCS) for ILC compared with invasive ductal carcinoma (I

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Rice, Dahlia Michelle, Karen Beatrice Salud Ching, Sahil Gambhir, and Edward Woo. "Residual cancer found on re-excision for close and positive margins after breast conservation for early-stage breast cancer: A single-institution review." Journal of Clinical Oncology 32, no. 26_suppl (2014): 55. http://dx.doi.org/10.1200/jco.2014.32.26_suppl.55.

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55 Background: The SSO/ASTRO guidelines for margins on breast-conservation therapy (BCT) were recently published, recommending re-excision for positive margins only defined as ink on invasive cancer. The aim of our study is to retrospectively analyze our institution’s re-excision rate and the rate of finding residual cancer in the re-excision specimen when re-excisions were performed for positive and/or close margins. We want to confirm that our institution’s data for re-excision rates and residual cancer rates are comparable to national data from where the SSO/ASTRO guidelines were derived. M

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Cate, Sarah P., Arielle Brooke Greenberg, Leah Bassin, et al. "The SSO/ASTRO Consensus on Breast Margins: Has it affected clinical practice?" Journal of Clinical Oncology 33, no. 28_suppl (2015): 148. http://dx.doi.org/10.1200/jco.2015.33.28_suppl.148.

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148 Background: Adequate margin width remains a subject of much controversy in breast conserving surgery. The Society of Surgical Oncology (SSO) and the American Society for Radiation Oncology (ASTRO) presented a consensus statement on margins in December 2014. This guideline stated that re-excision is recommended only in cases where tumor is present on inked margin. In this study, we sought to determine the consensus statement’s impact on re-excision practices at our institution. We examined re-excision rates eleven months before the release and 17 months after the release of the statement. M

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Krishna, Kanyadhara Lohita, B. S. Srinath, Divya Santosh, et al. "A comparative study of perioperative techniques to attain negative margins and spare healthy breast tissue in breast conserving surgery." Breast Disease 39, no. 3-4 (2021): 127–35. http://dx.doi.org/10.3233/bd-200443.

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BACKGROUND AND AIM: Traditionally lumpectomy as a part of breast-conserving surgery (BCS) is performed by palpation-guided method leading to positive margins and large excision volumes. There is no evidence suggesting that wide margin excisions decrease intra-breast tumour recurrence. Various perioperative techniques are used for margin assessment. We aimed to compare three commonly used techniques, i.e., ultrasound-guided surgery, palpation-guided surgery and cavity shaving for attaining negative margins and estimating the extent of healthy breast tissue resection. METHOD: A prospective compa

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Morinaga, Sei, Shinji Miwa, Norio Yamamoto, et al. "Clinical characteristics of patients with undergoing unplanned excisions of malignant soft tissue tumors." Journal of Orthopaedic Surgery 29, no. 3 (2021): 230949902110575. http://dx.doi.org/10.1177/23094990211057597.

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Introduction Malignant soft tissue tumors are rare tumors representing <1% of all malignancies. As these tumors are rare, it is not uncommon that malignant soft tissue tumor excision is performed without the required preoperative imaging, staging, or wide resection margins for sarcomas. The purpose of this study was to investigate the characteristics of patients with undergoing unplanned excisions. Risk factors for tumor recurrence and mortality in patients treated with unplanned excisions were also analyzed. Methods Forty-nine patients who underwent unplanned excision at other hospitals an

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Ulfa, Aulia, and Subagio. "Surgical Management of Facial Basal Cell Carcinoma: A Case Report Emphasizing the Need for Individualized Margin Assessment." Bioscientia Medicina : Journal of Biomedicine and Translational Research 8, no. 11 (2024): 5395–406. http://dx.doi.org/10.37275/bsm.v8i11.1120.

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Background: Basal cell carcinoma (BCC) is the most common form of skin cancer, and its incidence is steadily increasing. While surgical excision remains a cornerstone of BCC treatment, achieving complete tumor clearance while preserving healthy tissue and ensuring optimal cosmetic outcomes can be challenging, particularly in the facial region. This case report underscores the importance of individualized margin assessment in BCC excision. Case presentation: We present the case of a 52-year-old male with a nodular BCC on his left cheek. The lesion was excised with a 5mm margin under local anest

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Perdiou, Antonis, Ramona Dumitrescu, Daniela Jumanca, et al. "Leveraging Autofluorescence for Tumor Detection, Diagnosis, and Accurate Excision with Surgical Margin Assessment in Tumor Excision." Dentistry Journal 13, no. 1 (2024): 10. https://doi.org/10.3390/dj13010010.

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Background/Objectives: Oral cancer ranks among the top ten cancers globally, with a five-year survival rate below 50%. This study aimed to evaluate the effectiveness of autofluorescence-guided surgery compared to standard surgical methods in identifying tumor-free margins and ensuring complete excision. Methods: A prospective cohort of 80 patients was randomized into two groups: the control group underwent excision with a 10 mm margin based on clinical judgment, while the experimental group used autofluorescence guidance with a 5 mm margin beyond fluorescence visualization loss. Autofluorescen

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Vanni, Gianluca, Marco Pellicciaro, Nicola Di Lorenzo, et al. "Surgical De-Escalation for Re-Excision in Patients with a Margin Less Than 2 mm and a Diagnosis of DCIS." Cancers 16, no. 4 (2024): 743. http://dx.doi.org/10.3390/cancers16040743.

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The current surgical guidelines recommend an optimal margin width of 2 mm for the management of patients diagnosed with ductal carcinoma in situ (DCIS). However, there are still many controversies regarding re-excision when the optimal margin criteria are not met in the first resection. The purpose of this study is to understand the importance of surgical margin width, re-excision, and treatments to avoid additional surgery on locoregional recurrence (LRR). The study is retrospective and analyzed surgical margins, adjuvant treatments, re-excision, and LRR in patients with DCIS who underwent br

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Cigna, Emanuele, Mauro Tarallo, Michele Maruccia, Valentina Sorvillo, Alessia Pollastrini, and Nicolò Scuderi. "Basal Cell Carcinoma: 10 Years of Experience." Journal of Skin Cancer 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/476362.

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Introduction. Basal cell carcinoma (BCC) is a locally invasive malignant epidermal tumour. Incidence is increasing by 10% per year; incidence of metastases is minimal, but relapses are frequent (40%–50%). The complete excision of the BCC allows reduction of relapse.Materials and Methods. The study cohort consists of 1123 patients underwent surgery for basal cell carcinoma between 1999 and 2009. Patient and tumor characteristics recorded are: age; gender; localization (head and neck, trunk, and upper and lower extremities), tumor size, excisional margins adopted, and relapses.Results. The study

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Baba, Natsuki, Yasuhiro Nakamura, Hiroshi Kato, et al. "Survival analysis between narrower surgical margins and guideline-recommended margins for excision of cutaneous squamous cell carcinoma: A multicenter, retrospective study of 1,204 Japanese cases." Journal of Clinical Oncology 38, no. 15_suppl (2020): 10063. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.10063.

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10063 Background: Controversy exists regarding the optimal surgical margin for cutaneous squamous cell carcinoma (cSCC). Current NCCN Guidelines recommend excision with a 4–6-mm clinical margin for low-risk cSCC and wider ( > 6-mm) clinical margin for high-risk cSCC tumors. However, adherence to this guideline is often difficult, as high-risk cSCCs frequently occur on the faces of elderly patients. Thus, we aim to investigate the correlation between different surgical margins and prognosis in patients with cSCC. Methods: Patients with cSCC who had undergone surgical excision of the primary

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Chokechanachaisakul, A., C. A. Wesen, T. M. Hall, and J. S. Falk. "Multivariate analysis of predictors of positive or close margins in breast-conserving therapy." Journal of Clinical Oncology 29, no. 27_suppl (2011): 105. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.105.

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105 Background: Local recurrence rates after breast-conserving therapy (BCT) are increased with positive or close margin lumpectomy. This group of patients usually requires a re-excision lumpectomy or a completion mastectomy, causing delays in systemic therapy, and a less desirable cosmetic outcome. The objectives of this study were to identify any predictive risk factors that might be associated with positive or close lumpectomy margins (<1mm), and thus have implications for the planning of appropriate primary surgical excision. Methods: This was a retrospective cohort study of 195 consecu

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Marsden, J. R., Nigel Kirkham, Julia Newton, and Meirion Thomas. "Malignant melanoma excision margins." Lancet 341, no. 8838 (1993): 184. http://dx.doi.org/10.1016/0140-6736(93)90051-h.

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Nawrocki, Shiri, Nagy Mikhail, Sara Ghotb, and Amin Maghari. "Assessment of Shave Removal Without Further Excision in the Treatment of Spitz Nevi: A Retrospective Study of 58 Cases." Journal of Cutaneous Medicine and Surgery 24, no. 2 (2019): 144–48. http://dx.doi.org/10.1177/1203475419892956.

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Background Spitz nevi (or tumors) are noncancerous growths that are found particularly in the pediatric population. Their histologic features overlap with melanoma, but they have a favorable prognosis, even when showing atypical features. Objectives The aim of this research is to examine whether Spitz nevi can be sufficiently removed by adequate shave excisions without a subsequent excision. Methods Melan-A stained shave removal specimens (SRS) were obtained for 58 consecutively diagnosed Spitz nevi, along with slides of their postshave excision specimens. The SRS were reviewed for negative (c

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Gnanasekaran, Pritika, Niraj Balakrishnan, Navaneeth Ranjith, Rakshana Munusamy, and Naveen Bose J. "Assessing the efficacy of intraoperative fluorescence imaging for tumor margin identification in breast conserving surgery." Bioinformation 20, no. 12 (2024): 1927–30. https://doi.org/10.6026/9732063002001927.

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Breast-conserving surgery (BCS) aims to remove malignant breast tissue while preserving healthy tissue, with clear margins crucial for reducing recurrence and avoiding additional surgeries. This study evaluated the effectiveness of intraoperative fluorescence imaging (IFI) in achieving negative margins compared to standard intraoperative techniques in 100 retrospectively analyzed patients. IFI-assisted BCS achieved negative margins in 88% of cases versus 65% with standard methods (p < 0.001) and significantly reduced re-excision rates (8% vs. 22%, p = 0.002). Long-term recurrence rates over

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McGrath, Lindsay A., Adam Meeney, Zanna I. Currie, Hardeep Singh Mudhar, and Jennifer H. Tan. "Staged excision of primary periocular basal cell carcinoma: absence of residual tumour in re-excised specimens: a 10-year series." British Journal of Ophthalmology 103, no. 7 (2018): 976–79. http://dx.doi.org/10.1136/bjophthalmol-2018-312441.

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AimsThe aim is to study staged periocular basal cell carcinoma (BCC) excision in a tertiary oculoplastic referral centre in Sheffield, UK. In particular, we examined patients with close or positive margins and no tumour seen on re-excision to identify demographics and tumour characteristics in this population.MethodsA retrospective review of medical records of 437 cases of staged periocular BCC excisions over a 10-year period (2007–2017) was carried out. Patients had surgical excision with 3 mm clinically clear margins. Staged excision was performed for all cases included in this study. Standa

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Morrow, Monica, Kimberly J. Van Zee, Lawrence J. Solin, et al. "Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ." Journal of Clinical Oncology 34, no. 33 (2016): 4040–46. http://dx.doi.org/10.1200/jco.2016.68.3573.

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Background Controversy exists regarding the optimal negative margin width for ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation (WBRT). Methods A multidisciplinary consensus panel used a meta-analysis of margin width and ipsilateral breast tumor recurrence (IBTR) from a systematic review of 20 studies including 7883 patients and other published literature as the evidence base for consensus. Results Negative margins halve the risk of IBTR compared with positive margins defined as ink on DCIS. A 2 mm margin minimizes the risk of IBTR compared wit

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McSweeney, William, Matthew Leaning, and Darius Dastouri. "Keratinocyte Skin Cancers in General Surgery: The Impact of Anaesthesia, Trainee Supervision, and Choice of Reconstruction." Journal of Skin Cancer 2021 (April 13, 2021): 1–3. http://dx.doi.org/10.1155/2021/5537273.

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Background. Keratinocyte skin cancers are common in Australia, incurring disproportionately high health expenditure in comparison with mortality. General surgeons often excise these lesions as day-surgery. Balancing individual complexities of these cancers with trainee supervision and health expenditure is key to deliver efficacious care and maintain day-surgery volume for patients during a pandemic. Methods. A retrospective, cross-sectional study was performed, examining 414 procedures from January 2019 to December 2020. Pathology was reviewed, and benign lesions excluded. Complete excision w

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Chiu, Jeffrey C., Saira Ajmal, Xiang Zhu, Elizabeth Griffith, Tiffany Encarnacion, and Louis Barr. "Radioactive Seed Localization of Nonpalpable Breast Lesions in an Academic Comprehensive Cancer Program Community Hospital Setting." American Surgeon 80, no. 7 (2014): 675–79. http://dx.doi.org/10.1177/000313481408000722.

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Wire localized excision (WLE) has been a long-standing method for localization of nonpalpable breast lesions. Disadvantages of this method include difficulty locating the wire tip in relation to borders of the lesion, imprecise placement of the wire, and the need to place the wire shortly before scheduled surgery. These shortcomings may lead to a high positive margin rate requiring re-excision to obtain clear margins for breast cancer. Radioactive seed localized excision (RSLE) of nonpalpable breast lesions has been advocated as a safe and effective alternative to WLE. The primary endpoints of

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Wolf, J. H., Y. Wen, D. Axelrod, et al. "Higher Volume at Time of Breast Conserving Surgery Reduces Re-Excision in DCIS." International Journal of Surgical Oncology 2011 (2011): 1–10. http://dx.doi.org/10.1155/2011/785803.

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Purpose. The purpose of this study was to compare the surgical and pathological variables which impact rate of re-excision following breast conserving therapy (BCS) with or without concurrent additional margin excision (AM).Methods. The pathology database was queried for all patients with DCIS from January 2004 to September 2008. Pathologic assessment included volume of excision, subtype, size, distance from margin, grade, necrosis, multifocality, calcifications, and ER/PR status.Results. 405 cases were identified and 201 underwent BCS, 151-BCS-AM, and 53-mastectomy. Among the 201 BCS patients

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Gray, Kelsey, Reed Ayabe, Andrew Shover, Ashkan Moazzez, Junko Ozao-Choy, and Christine Dauphine. "Can Selective Image-Guided Intraoperative Margin Resection Improve Re-Excision Rates after Lumpectomy in Ductal Carcinoma In Situ of the Breast?" American Surgeon 84, no. 10 (2018): 1580–83. http://dx.doi.org/10.1177/000313481808401008.

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The rate of positive margins after breast conserving surgery (BCS) can be as high as 50 per cent, and optimal techniques for reducing rates of positive margins are presently debated. Our institution has previously demonstrated low rates of margin re-excision using a standardized approach to intraoperative selective margin excision for patients undergoing BCS. We hypothesized that this approach can be used for patients with ductal carcinoma in situ (DCIS) and can yield similar rates when compared with invasive cancer. We performed a retrospective analysis of women with breast cancer who underwe

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Barnes, Martyn Lawrence, Steven Ross, Alison Jayne Barnes, and Leo George McClymont. "S108 – Close Margin Excision Outcomes in Head and Neck Skin Cancer." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P113. http://dx.doi.org/10.1016/j.otohns.2008.05.281.

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Objectives 1) Determine clinical and histological outcomes for patients following close margin excisions of head and neck skin cancer. 2) Guide decisions regarding further intervention and follow-up. Methods Retrospective review of Otolaryngology department skin excisions from 1991 to 2008. Pathology reports and casenotes were reviewed to identify lesions excised with less than 1mm margins and determine their further management and outcome. Kaplan-Meier survival analysis was used to obtain the number needed to follow up for 2 years (NNFU) to detect a recurrence. Results Of 1223 skin cancers, 1

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Sanchez, Daisy, Erica Bloomquist, Heather Wright, and Yoav Barnavon. "Immediate Nipple Reconstruction With Areolar Flaps After Nipple Excision." Annals of Plastic Surgery 91, no. 2 (2023): 211–14. http://dx.doi.org/10.1097/sap.0000000000003570.

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Abstract Nipple-sparing mastectomies (NSMs) have become a common surgical approach in the management of invasive breast cancers and ductal carcinoma in situ, and as a risk-reducing approach in genetically predisposed patients. The current standard of care in the management of positive nipple margin after NSM is total excision of the nipple-areola complex. In this article, we aimed to present a case series describing a novel approach to positive nipple margins with nipple-only excision and immediate nipple reconstruction using areolar flaps in patients who underwent NSM for noninvasive tumors.

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Morinaga, Sei, Norio Yamamoto, Katsuhiro Hayashi, et al. "Clinical outcomes and life expectancy of patients with unplanned excisions of soft tissue sarcoma." Journal of Clinical Oncology 40, no. 16_suppl (2022): e23554-e23554. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e23554.

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e23554 Background: As soft tissue sarcomas are rare, it is not uncommon that soft tissue sarcoma excision is performed without the required preoperative imaging, staging, or wide resection margins for sarcomas. This study investigated the characteristics of unplanned excision and analyzed the recurrence, life expectancy, and proper treatment for unplanned excision. Methods: Patients who underwent unplanned excision at another institution followed by additional wide excision at our hospital from January 2002 to December 2018 were identified. Forty-two patients met our criteria. The relationship

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MALIK, AH, R. AHMAD, Z. YOUNIS, A. KHAN, and Z. TAUQEER. "OUTCOMES OF BASAL CELL CARCINOMA EXCISION IN HEAD AND NECK AREA: EVALUATING THE EFFICACY OF 5MM CLEARANCE MARGIN." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1062. http://dx.doi.org/10.54112/bcsrj.v2024i1.1062.

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Basal cell carcinoma (BCC) is the most prevalent type of skin cancer affecting the head and neck region. Surgical excision with histologically negative margins is still the mainstay of management for patients with this condition. Objective: To evaluate the efficacy of using a 5mm clearance margin in the surgical treatment of BCCs in the head and neck area regarding recurrence rate, functional impairment, and cosmetic satisfaction. Methods: This descriptive study was conducted at the Department of Plastic Surgery, Lady Reading Hospital, Peshawar, between 1st June 2023 and 31st May 2024. Male an

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Stockley, Cecily, Shiva Bahmanyar, Yuan Xu, Jeffrey Cao, May Lynn Quan, and Alison Laws. "Abstract P3-07-07: 10-Year Local Recurrence Rates Following Selective Omission of Re-excision for Patients with Ductal Carcinoma in Situ and Margins." Clinical Cancer Research 31, no. 12_Supplement (2025): P3–07–07—P3–07–07. https://doi.org/10.1158/1557-3265.sabcs24-p3-07-07.

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Abstract Background: Current guidelines recommend ≥2mm margins for ductal carcinoma in situ (DCIS) with or without microinvasion to optimize local control following breast conserving surgery (BCS). There is some evidence to suggest it is acceptable to omit re-excision for “close” margins (i.e. not on-ink but &lt;2mm), particularly when radiation therapy (RT) is planned. This study evaluates 10-year local recurrence (LR) rates following selective omission of re-excision in patients with DCIS and margins &lt;2mm. Methods: We conducted a retrospective population-based cohort study on pati

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Modin, Maja, Helena Svensson, Ylva Bergsten Wanders, Noora Neittanmäki, Jan Siarov, and John Paoli. "Incomplete Excision Rate for Lentigo Maligna and Associated Risk Factors." Acta Dermato-Venereologica 104 (October 3, 2024): adv40535. http://dx.doi.org/10.2340/actadv.v104.40535.

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Standard treatment for lentigo maligna (LM) is surgical excision, yet insights into the frequency of and risk factors for incomplete excisions remain limited. The primary objectives were to assess the incomplete excision rate (IER) in primary LM and to explore potential risk factors for incomplete excisions. A retrospective analysis was conducted encompassing consecutive histopathologically confirmed LMs from 2014–2020. Descriptive statistics were used for LM characteristics and IER, while uni- and multivariate analyses were used for calculating risk factors. The study included 395 LMs with an

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