Relevant bibliographies by topics / Exosome Complex

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  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Exosome Complex'

Author: Grafiati
Published: 4 June 2021
Last updated: 19 February 2022

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Journal articles on the topic "Exosome Complex"

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Théry, Clotilde, Armelle Regnault, Jérôme Garin, et al. "Molecular Characterization of Dendritic Cell-Derived Exosomes." Journal of Cell Biology 147, no. 3 (1999): 599–610. http://dx.doi.org/10.1083/jcb.147.3.599.

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Exosomes are membrane vesicles secreted by hematopoietic cells upon fusion of late multivesicular endosomes with the plasma membrane. Dendritic cell (DC)-derived exosomes induce potent antitumor immune responses in mice, resulting in the regression of established tumors (Zitvogel, L., A. Regnault, A. Lozier, J. Wolfers, C. Flament, D. Tenza, P. Ricciardi-Castagnoli, G. Raposo, and S. Amigorena. 1998. Nat. Med. 4:594–600). To unravel the molecular basis of exosome-induced immune stimulation, we now analyze the regulation of their production during DC maturation and characterize extensively thei
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Peng, Ching-Tien. "Exosome-Transferred APOC3-Ncrna Complex Mediates Iron Regulation in Beta-Thalassemia Major." Blood 126, no. 23 (2015): 963. http://dx.doi.org/10.1182/blood.v126.23.963.963.

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Background: Exosomes are small membrane vesicles (50-90 mm in diameter) containing bioactive proteins and genetic materials that may be transferred to accept cells, resulting in potent biological effects in the circulatory system. Exosome-transferred APOC3-ncRNA may be a crucial function in iron regulation. However, the role in β-thalassemia major is remains unclear. Aim: The aim of this study was to investigate how Exosome-transferred APOC3-ncRNA adapts to iron regulation in β-thalassemia major. Design: Using Proteomics, RNA-sequencing and lncRNA Q-PCR array, we demonstrated expression of exo
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Makino, Debora Lika, and Elena Conti. "Structure determination of an 11-subunit exosome in complex with RNA by molecular replacement." Acta Crystallographica Section D Biological Crystallography 69, no. 11 (2013): 2226–35. http://dx.doi.org/10.1107/s0907444913011438.

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The RNA exosome is an evolutionarily conserved multi-protein complex involved in the 3′ degradation of a variety of RNA transcripts. In the nucleus, the exosome participates in the maturation of structured RNAs, in the surveillance of pre-mRNAs and in the decay of a variety of noncoding transcripts. In the cytoplasm, the exosome degrades mRNAs in constitutive and regulated turnover pathways. Several structures of subcomplexes of eukaryotic exosomes or related prokaryotic exosome-like complexes are known, but how the complete assembly is organized to fulfil processive RNA degradation has been u
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Sinha, Seema, Daisuke Hoshino, Nan Hyung Hong, et al. "Cortactin promotes exosome secretion by controlling branched actin dynamics." Journal of Cell Biology 214, no. 2 (2016): 197–213. http://dx.doi.org/10.1083/jcb.201601025.

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Exosomes are extracellular vesicles that influence cellular behavior and enhance cancer aggressiveness by carrying bioactive molecules. The mechanisms that regulate exosome secretion are poorly understood. Here, we show that the actin cytoskeletal regulatory protein cortactin promotes exosome secretion. Knockdown or overexpression of cortactin in cancer cells leads to a respective decrease or increase in exosome secretion, without altering exosome cargo content. Live-cell imaging revealed that cortactin controls both trafficking and plasma membrane docking of multivesicular late endosomes (MVE
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Ludwig, Nils, Theresa L. Whiteside, and Torsten E. Reichert. "Challenges in Exosome Isolation and Analysis in Health and Disease." International Journal of Molecular Sciences 20, no. 19 (2019): 4684. http://dx.doi.org/10.3390/ijms20194684.

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A growing body of evidence emphasizes the important role exosomes in different physiological and pathological conditions. Exosomes, virus-size extracellular vesicles (EVs), carry a complex molecular cargo, which is actively processed in the endocytic compartment of parental cells. Exosomes carry and deliver this cargo to recipient cells, serving as an intercellular communication system. The methods for recovery of exosomes from supernatants of cell lines or body fluids are not uniformly established. Yet, studies of the quality and quantity of exosome cargos underlie the concept of “liquid biop
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Shi, Chunhua, Daiana Alvarez-Olmedo, Yuan Zhang, Badal S. B. Pattar, and Edward R. O’Brien. "The Heat Shock Protein 27 Immune Complex Enhances Exosomal Cholesterol Efflux." Biomedicines 8, no. 8 (2020): 290. http://dx.doi.org/10.3390/biomedicines8080290.

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Previously, we demonstrated that Heat Shock Protein 27 (HSP27) reduces the inflammatory stages of experimental atherogenesis, is released by macrophage (MΦ) exosomes and lowers cholesterol levels in atherosclerotic plaques. Recently, we discovered that natural autoantibodies directed against HSP27 enhance its signaling effects, as HSP27 immune complexes (IC) interact at the cell membrane to modulate signaling. We now seek to evaluate the potential role of the HSP27 IC on MΦ exosomal release and cholesterol export. First, in human blood samples, we show that healthy control subjects have 86% mo
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An, Xiuli. "Exosome complex and erythropoiesis." Blood 124, no. 14 (2014): 2169–71. http://dx.doi.org/10.1182/blood-2014-08-596353.

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Rabesandratana, Herisoa, Jean-Pierre Toutant, Hubert Reggio, and Michel Vidal. "Decay-Accelerating Factor (CD55) and Membrane Inhibitor of Reactive Lysis (CD59) Are Released Within Exosomes During In Vitro Maturation of Reticulocytes." Blood 91, no. 7 (1998): 2573–80. http://dx.doi.org/10.1182/blood.v91.7.2573.

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Abstract Exosomes are membrane vesicles released by reticulocytes during their maturation into erythrocytes. They have a clearing function because of their enrichment with some proteins known to decrease or disappear from the cell surface during maturation, eg, acetylcholinesterase (AChE) and transferrin receptor (TfR), respectively. To better understand the molecular events leading to protein sorting in exosomes, we analyzed the expression of glycosylphosphatidylinositol (GPI)-anchored proteins on the exosome surface through a technique involving bead coupling and flow cytometry immunodetecti
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Rabesandratana, Herisoa, Jean-Pierre Toutant, Hubert Reggio, and Michel Vidal. "Decay-Accelerating Factor (CD55) and Membrane Inhibitor of Reactive Lysis (CD59) Are Released Within Exosomes During In Vitro Maturation of Reticulocytes." Blood 91, no. 7 (1998): 2573–80. http://dx.doi.org/10.1182/blood.v91.7.2573.2573_2573_2580.

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Exosomes are membrane vesicles released by reticulocytes during their maturation into erythrocytes. They have a clearing function because of their enrichment with some proteins known to decrease or disappear from the cell surface during maturation, eg, acetylcholinesterase (AChE) and transferrin receptor (TfR), respectively. To better understand the molecular events leading to protein sorting in exosomes, we analyzed the expression of glycosylphosphatidylinositol (GPI)-anchored proteins on the exosome surface through a technique involving bead coupling and flow cytometry immunodetection. The p
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Tschuschke, Max, Ievgeniia Kocherova, Artur Bryja, et al. "Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes." Journal of Clinical Medicine 9, no. 2 (2020): 436. http://dx.doi.org/10.3390/jcm9020436.

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Exosomes are a heterogenous subpopulation of extracellular vesicles 30–150 nm in range and of endosome-derived origin. We explored the exosome formation through different systems, including the endosomal sorting complex required for transport (ESCRT) and ESCRT-independent system, looking at the mechanisms of release. Different isolation techniques and specificities of exosomes from different tissues and cells are also discussed. Despite more than 30 years of research that followed their definition and indicated their important role in cellular physiology, the exosome biology is still in its in
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Dissertations / Theses on the topic "Exosome Complex"

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LaCava, John. "Activation of the yeast exosome complex." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/12383.

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This study concentrates on structural and functional analysis of the <i>S. cerevisiae </i>exosome complex. It is likely that these exoribonucleases are in a complex in order to inhibit potential non-specific activities of the individual components. In this way a potent but highly specific RNA degradation machinery is maintained. This model is supported by the lack of free components <i>in vivo </i>and the relatively low enzymatic activity <i>in vitro </i>of the purified exosome complex. This study shows how the exosome can be stimulated into a highly effective and processive activity <i>in vit
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Cordiner, Ross Andrew Alex. "The cellular functions of the microprocessor complex." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25877.

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DGCR8 (DiGeorge critical region 8) protein constitutes part of the Microprocessor complex together with Drosha, and is involved in the nuclear phase of microRNA (miRNA) biogenesis. DGCR8 recognises the hairpin RNA substrates of precursor miRNAs through two double-stranded RNA (dsRNA) binding motifs and acts as a molecular anchor to direct Drosha cleavage at the base of the pri-miRNA hairpin. Recent characterisation of the RNA targets of the Microprocessor by HITSCLIP of DGCR8 protein revealed that this complex also binds and regulates the stability of several types of transcripts, including mR
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Audin, Maxime [Verfasser], and Remco [Akademischer Betreuer] Sprangers. "NMR studies of the archaeal exosome complex / Maxime Audin ; Betreuer: Remco Sprangers." Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1165236028/34.

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Axhemi, Armend. "Synergy Between the Exoribonucleases Rrp6p and Rrp44p in the Nuclear Exosome Complex." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586282591705441.

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Sikorska, Natalia. "The phosphorolytic activity of the exosome core complex contributes to rRNA maturation in Arabidopsis thaliana." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ070/document.

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L’exosome joue un rôle fondamental dans la dégradation de 3’ en 5’ et la maturation des ARNs chez les eucaryotes. Le "coeur" de l’exosome est composé de 9 sous-unités (EXO9). EXO9 est catalytiquement inactif chez l’homme et la levure, et est associé à deux RNases, Rrp6 et Rrp44, responsables de l’activité exonucléolytique de l’exosome. Mes travaux de thèse démontrent que chez Arabidopsis, le coeur de l’exosome EXO9 possède une activité catalytique intrinsèque. Cette activité est dépendante de la présence de phosphate, produit des nucléosides diphosphates et est réversible. Elle possède de ce f
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Kong, Ka-yiu, and 江家耀. "Characterization of the roles of yeast nuclear exosome cofactor TRAMP complex in pre-mRNA splicing." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193522.

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In budding yeast, the Trf4/5p-Air1/2p-Mtr4p polyadenylation (TRAMP) complex recognizes unwanted RNA transcripts in the nucleus and then targets them to the nuclear exosome for rapid degradation, constituting an important pathway of nuclear RNA quality control. Each pre-mRNA splicing event unavoidably generates a RNA side-product that should be recognized by TRAMP and then removed by the nuclear exosome to prevent the potentially harmful sequestration of splicing factors and/or ribonucleotides. While successful pre-mRNA splicing inevitably produces a spliced-out intron, errors in pre-mRNA splic
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Cvetković, Miloš [Verfasser], and Remco [Akademischer Betreuer] Sprangers. "NMR Studies of RNA Degradation by the Archaeal Exosome Complex / Miloš Cvetković ; Betreuer: Remco Sprangers." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1165577585/34.

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Shah, Sneha. "Studying the function and regulation of non-coding transcription in fission yeast by the exosome complex." Thesis, University of Oxford, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669785.

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Zhao, Lifang. "ECERIFERUM7 subunit of the exosome, SUPERKILLER complex and small RNA species regulate cuticular wax biosynthesis in Arabidopsis thaliana stems." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52668.

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The primary aerial surfaces of higher plants are covered by a continuous hydrophobic lipid layer called the cuticle, which is synthesized by the epidermal cells and provides protection against desiccation and environmental stresses. The cuticle is mainly composed of the cutin polyester matrix and cuticular waxes. Although the biosynthetic pathways of cuticular waxes are relatively well documented, how wax biosynthesis is regulated is not completely understood. The major goal of my thesis was to investigate the ECERIFERUM7 (CER7)-mediated mechanism of regulation of cuticular wax biosynthesis in
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川本, 崇仁. "U snRNA の成熟と分解の分子機構の研究". Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263510.

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Book chapters on the topic "Exosome Complex"

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Delan-Forino, Clémentine, and David Tollervey. "Mapping Exosome–Substrate Interactions In Vivo by UV Cross-Linking." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9822-7_6.

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AbstractThe RNA exosome complex functions in both the accurate processing and rapid degradation of many classes of RNA in eukaryotes and Archaea. Functional and structural analyses indicate that RNA can either be threaded through the central channel of the exosome or more directly access the active sites of the ribonucleases Rrp44 and Rrp6, but in most cases, it remains unclear how many substrates follow each pathway in vivo. Here we describe the method for using an UV cross-linking technique termed CRAC to generate stringent, transcriptome-wide mapping of exosome–substrate interaction sites in vivo and at base-pair resolution.
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Matos, Rute G., Sandra C. Viegas, and Cecília M. Arraiano. "In Vitro Characterization of the Prokaryotic Counterparts of the Exosome Complex." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9822-7_3.

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Cruz, Cristina, and Jonathan Houseley. "Protocols for Northern Analysis of Exosome Substrates and Other Noncoding RNAs." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9822-7_5.

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AbstractOver the past decade a plethora of noncoding RNAs (ncRNAs) have been identified, initiating an explosion in RNA research. Although RNA sequencing methods provide unsurpassed insights into ncRNA distribution and expression, detailed information on structure and processing are harder to extract from sequence data. In contrast, northern blotting methods provide uniquely detailed insights into complex RNA populations but are rarely employed outside specialist RNA research groups. Such techniques are generally considered difficult for nonspecialists, which is unfortunate as substantial technical advances in the past few decades have solved the major challenges. Here we present simple, reproducible and highly robust protocols for separating glyoxylated RNA on agarose gels and heat denatured RNA on polyacrylamide–urea gels using standard laboratory electrophoresis equipment. We also provide reliable transfer and hybridization protocols that do not require optimization for most applications. Together, these should allow any molecular biology lab to elucidate the structure and processing of ncRNAs of interest.
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Zigáčková, Dagmar, Veronika Rájecká, and Štěpánka Vaňáčová. "Purification of Endogenous Tagged TRAMP4/5 and Exosome Complexes from Yeast and In Vitro Polyadenylation-Exosome Activation Assays." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9822-7_12.

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Weick, Eva-Maria, John C. Zinder, and Christopher D. Lima. "Strategies for Generating RNA Exosome Complexes from Recombinant Expression Hosts." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9822-7_20.

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Lee, Seok Hee, and Byeong Chun Lee. "The Interplay Between Oviduct-Derived Exosomes and Cumulus-Oocyte Complexes." In Role of Exosomes in Biological Communication Systems. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6599-1_4.

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Winczura, Kinga, Michal Domanski, and John LaCava. "Affinity Proteomic Analysis of the Human Exosome and Its Cofactor Complexes." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9822-7_15.

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Zinder, John C., and Christopher D. Lima. "Reconstitution of S. cerevisiae RNA Exosome Complexes Using Recombinantly Expressed Proteins." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9822-7_21.

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Olinares, Paul Dominic B., and Brian T. Chait. "Native Mass Spectrometry Analysis of Affinity-Captured Endogenous Yeast RNA Exosome Complexes." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9822-7_17.

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Xiang, Yufei, Zhuolun Shen, and Yi Shi. "Chemical Cross-Linking and Mass Spectrometric Analysis of the Endogenous Yeast Exosome Complexes." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9822-7_18.

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Conference papers on the topic "Exosome Complex"

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Edahiro, R., Y. Takeda, T. Koba, et al. "Quantitative Proteomics of Serum Exosomes to Identify Novel Biomarkers for Mycobacterium Avium Complex and Tuberculosis." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4492.

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