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Journal articles on the topic 'Expanded Disability Status Scale'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

NA;. "Appendix F: Expanded Disability Status Scale (EDSS)." CONTINUUM: Lifelong Learning in Neurology 10 (December 2004): 253–54. http://dx.doi.org/10.1212/01.con.0000293621.60699.95.

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Ferreira Vasconcelos, Claudia Cristina, Luiz Claudio Santos Thuler, Gutemberg Augusto Cruz dos Santos, et al. "Differences in the progression of primary progressive multiple sclerosis in Brazilians of African descent versus white Brazilian patients." Multiple Sclerosis Journal 16, no. 5 (2010): 597–603. http://dx.doi.org/10.1177/1352458509360987.

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Recent studies have suggested faster clinical progression and greater disability in multiple sclerosis patients of African descent. This study analysed the effect of ethnicity on progression and disability. Sixty-five patients with primary progressive multiple sclerosis were selected and classified as being of African descent or white. Time from onset of the disease until reaching Expanded Disability Status Scale grades 3, 6, and 8 was assessed, as well as irreversible disability (Expanded Disability Status Scale grade maintained for ≥6 months). In the African descent group, the median time to

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3

Zurawski, Jonathan, Bonnie I. Glanz, Alicia Chua, et al. "Time between expanded disability status scale (EDSS) scores." Multiple Sclerosis and Related Disorders 30 (May 2019): 98–103. http://dx.doi.org/10.1016/j.msard.2019.02.007.

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Demir, Serkan. "Expanded Disability Status Scale (EDSS) in Multiple Sclerosis." Cam and Sakura Medical Journal 2, no. 3 (2022): 82–89. http://dx.doi.org/10.4274/csmedj.galenos.2022.2022-11-11.

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Fernández, Oscar, Marcos Papais Alvarenga, Miguel Guerrero, et al. "The efficacy of natalizumab in patients with multiple sclerosis according to level of disability: results of an observational study." Multiple Sclerosis Journal 17, no. 2 (2010): 192–97. http://dx.doi.org/10.1177/1352458510385507.

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Background: Little is known about how the level of disability at the start of treatment with natalizumab affects its efficacy. Objectives: The aim of this study was to investigate the effect of natalizumab on relapses in patients with different levels of baseline disability associated with MS. Methods: This single-centre observational study collected demographic data for patients followed prospectively and who were scheduled to start natalizumab therapy due to the presence of disease activity. The annualized relapse rate (ARR) and Kurtzke Expanded Disability Status Scale scores were analysed f

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Merkt, Helene, Dena Sadeghi Bahmani, Pasquale Calabrese, et al. "Multiple Sclerosis: Associations Between Physical Disability and Depression Are Not Mediated by Self-Reported Physical Activity." Perceptual and Motor Skills 124, no. 5 (2017): 974–91. http://dx.doi.org/10.1177/0031512517711851.

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This study investigated the interrelatedness of physical disability, physical activity, and depression among patients with multiple sclerosis (MS). We hypothesized that self-reported physical activity would mediate the effect of disability on depressive symptoms. Twenty-seven patients with MS (mean age: 49 years; 44.5% females) completed self-rating scales covering sociodemographic variables, intake of antidepressants, physical activity, and symptoms of depression; disability was measured by the Expanded Disability Status Scale. We found a higher level of disability to be significantly associa

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Prinster, A., M. Quarantelli, R. Lanzillo, et al. "A voxel-based morphometry study of disease severity correlates in relapsing— remitting multiple sclerosis." Multiple Sclerosis Journal 16, no. 1 (2009): 45–54. http://dx.doi.org/10.1177/1352458509351896.

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Previous studies have shown a preferential loss of grey matter in fronto-temporal regions in patients with multiple sclerosis. Studies of correlates of disease severity are more controversial, because some studies have suggested an association between sensorimotor cortex atrophy and Expanded Disability Status Scale score, while others did not find such a correlation. The objective of this study was to assess the correlation of regional loss of grey matter and white matter with indexes of clinical and radiological severity in relapsing—remitting multiple sclerosis, including the Expanded Disabi

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Bermel, RA, B. Weinstock-Guttman, D. Bourdette, P. Foulds, X. You, and RA Rudick. "Intramuscular interferon beta-1a therapy in patients with relapsing-remitting multiple sclerosis: a 15-year follow-up study." Multiple Sclerosis Journal 16, no. 5 (2010): 588–96. http://dx.doi.org/10.1177/1352458509360549.

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Disease-modifying drugs are initiated early and continued for years in patients with multiple sclerosis. Long-term tolerability and impact are not known. The objective of this study was to evaluate long-term tolerability of intramuscular interferon beta-1a and effects on disability and quality of life. Patients were evaluated an average of 15 years after randomization into a placebo-controlled, double-blind trial of intramuscular interferon beta-1a for relapsing multiple sclerosis. Patient-reported Expanded Disability Status Scale, the Short Form-36, a visual analog scale of self-care independ

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Lechner-Scott, J., L. Kappos, M. Hofman, et al. "Can the Expanded Disability Status Scale be assessed by telephone?" Multiple Sclerosis Journal 9, no. 2 (2003): 154–59. http://dx.doi.org/10.1191/1352458503ms884oa.

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Information from patients who are unable to continue their visits to a study centre may be of major importance for the interpretatio n of results in multiple sclerosis (MS) clinical trials. To validate a questionnaire based on the Expanded Disability Status Scale (EDSS), patients in five different European centres were assessed independently by pairs of trained EDSS raters, first by telepho ne interview and a few days later by standardized neurological examination. Seventy women and 40 men with an average age of 43.7 years (range 19 -74 years) were included in the study. Mean EDSS score at the

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Kurtzke, John F. "Historical and Clinical Perspectives of the Expanded Disability Status Scale." Neuroepidemiology 31, no. 1 (2008): 1–9. http://dx.doi.org/10.1159/000136645.

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11

Cho, Joong-Yang, Keun-Sik Hong, Ho Jin Kim, et al. "Disability weight for each level of the Expanded Disability Status Scale in multiple sclerosis." Multiple Sclerosis Journal 20, no. 9 (2014): 1217–23. http://dx.doi.org/10.1177/1352458513518259.

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Background: The Expanded Disability Status Scale (EDSS) is the most widely employed ordinal disability scale in multiple sclerosis (MS). However, how far apart the individual EDSS levels are along the disability spectrum has not been formally quantified. Objectives: The objective of this paper is to generate refined disability weights (DWs) for each of the ordinal EDSS levels. Methods: We performed the person trade-off (PTO) procedure to derive DWs of five representative EDSS categories (2, 4, 6, 7 and 9), and DWs of the remaining EDSS categories were assigned by linear interpolation. The modi

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van Winsen, Lisa ML, Jolijn J. Kragt, Erwin LJ Hoogervorst, Chris H. Polman, and Bernard MJ Uitdehaag. "Outcome measurement in multiple sclerosis: detection of clinically relevant improvement." Multiple Sclerosis Journal 16, no. 5 (2010): 604–10. http://dx.doi.org/10.1177/1352458509359922.

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Because the development of new treatments in multiple sclerosis as well as the awareness of the importance of patient-oriented measures have become more important in the last two decades, new outcome measures have been developed with the aim of being more responsive to change and more clinically relevant to patients. The ability to detect improvement is sparsely studied. In the present study we evaluate the responsiveness of the Expanded Disability Status Scale and two quantitative tests (the timed 25-foot walk test and the nine-hole peg test) separately and in combination, to detect improveme

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Collins, Christian DE, Ben Ivry, James D. Bowen, et al. "A comparative analysis of Patient-Reported Expanded Disability Status Scale tools." Multiple Sclerosis Journal 22, no. 10 (2016): 1349–58. http://dx.doi.org/10.1177/1352458515616205.

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Background: Patient-Reported Expanded Disability Status Scale (PREDSS) tools are an attractive alternative to the Expanded Disability Status Scale (EDSS) during long term or geographically challenging studies, or in pressured clinical service environments. Objectives: Because the studies reporting these tools have used different metrics to compare the PREDSS and EDSS, we undertook an individual patient data level analysis of all available tools. Methods: Spearman’s rho and the Bland–Altman method were used to assess correlation and agreement respectively. Results: A systematic search for valid

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Barkhof, F. "MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS)." Multiple Sclerosis 5, no. 4 (1999): 283–86. http://dx.doi.org/10.1191/135245899678846221.

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Barkhof, Frederik. "MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS)." Multiple Sclerosis Journal 5, no. 4 (1999): 283–86. http://dx.doi.org/10.1177/135245859900500415.

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Magnetic resonance (MR) imaging is very sensitive in showing disseminated MS lesions. Subclinical MR progression occurs frequently, explaining why MR is now used to monitor treatment, even without measurable consequences, of new MR lesions to the patient at this moment. In the light of this clinico-radiological paradox, the significance of MR in MS is discussed, particularly in relation with the expanded disability status scale (EDSS). Gadolinium-enhancing lesions correlate with the occurrence of relapses, CSF myelin breakdown products and, in patients with relapsingremitting disease, with hig

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Avşar Ertürk, Fatma, Bülent Güven, and Hayat Güven. "Factors affecting response to relapse treatment in multiple sclerosis patients." Journal of Health Sciences and Medicine 8, no. 3 (2025): 405–10. https://doi.org/10.32322/jhsm.1608737.

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Aims: Relapses, a hallmark of multiple sclerosis, often lead to functional loss and a decline in quality of life. While the accelerating effect of intravenous methylprednisolone treatment on the recovery from multiple sclerosis relapses is well established, the rates of recovery can vary between relapses. This study aimed to evaluate the responses to intravenous methylprednisolone treatment administered during relapses in multiple sclerosis patients and to investigate the clinical factors and imaging characteristics influencing these responses. Methods: Patients diagnosed with relapsing-remitt

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Markowitz, Clyde E., Mary D. Hughes, Daniel D. Mikol, Lisa Shi, MerriKay Oleen-Burkey, and Douglas R. Denney. "Expanded Disability Status Scale Calculator for Handheld Personal Digital Assistant: Reliability Study." International Journal of MS Care 10, no. 2 (2008): 33–39. http://dx.doi.org/10.7224/1537-2073-10.2.33.

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Through a standard neurological examination, the Expanded Disability Status Scale (EDSS) score is traditionally determined by a pen-and-paper method. The objectives of this study were to compare the interrater/method reliability of EDSS scores obtained through the pen-and-paper method with those obtained with the EDSS Calculator, evaluate test-retest reliability of the EDSS Calculator, and examine the validity of EDSS Calculator scores through correlation with the Ambulation Index (AI). During a single office visit, 62 subjects with multiple sclerosis (MS) from six study centers had disability

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Salih, Rand, and Hanan L. Al-Omary. "Expanded disability status scale in Multiple Sclerosis: Relationship to visual evoked potential." Journal of the Faculty of Medicine Baghdad 64, no. 2 (2022): 96–101. http://dx.doi.org/10.32007/jfacmedbagdad.6421925.

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Background: Multiple sclerosis (MS) prevalence in Iraq is 11.73/100,000 it causes disability in younger adults. Expanded Disability Status Scale (EDSS) can monitor MS disability while Visually Evoked Potentials (VEP) serves as a marker of myelination. Objectives: To explore the relationship between EDSS and VEPs in multiple sclerosis patients. Patients and Methods: A cross-sectional study was conducted in Ghazi Al- Hariri Hospital from first of Nov 2021 till the end of Jan 2022. Fifty patients with multiple sclerosis were compared to 50 healthy individuals. EDSS Data were collected using a str

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Twork, Sabine, Susanne Wiesmeth, Milena Spindler, et al. "Disability status and quality of life in multiple sclerosis: non-linearity of the Expanded Disability Status Scale (EDSS)." Health and Quality of Life Outcomes 8, no. 1 (2010): 55. http://dx.doi.org/10.1186/1477-7525-8-55.

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Hatipoglu, Hasan, Sibel Canbaz Kabay, Mujgan Gungor Hatipoglu, and Hilmi Ozden. "Expanded Disability Status Scale-Based Disability and Dental-Periodontal Conditions in Patients with Multiple Sclerosis." Medical Principles and Practice 25, no. 1 (2015): 49–55. http://dx.doi.org/10.1159/000440980.

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Cao, Hua, Laurent Peyrodie, Samuel Boudet, et al. "Expanded Disability Status Scale (EDSS) estimation in multiple sclerosis from posturographic data." Gait & Posture 37, no. 2 (2013): 242–45. http://dx.doi.org/10.1016/j.gaitpost.2012.07.011.

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Ravnborg, M., M. Blinkenberg, F. Sellebjerg, M. Ballegaard, S. Helweg Larsen, and P. Soelberg Sørensen. "Responsiveness of the Multiple Sclerosis Impairment Scale in comparison with the Expanded Disability Status Scale." Multiple Sclerosis Journal 11, no. 1 (2005): 81–84. http://dx.doi.org/10.1191/1352458505ms1120oa.

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The Multiple Sclerosis Impairment Scale (MSIS) is a measure of accumulated deficits assessed by means of a standard neurological examination. We compared the responsiveness of the MSIS with that of the Expanded Disability Status Scale (EDSS). We reviewed 4300 records collected systematically from 1995 to 2003 and identified 534 patients who had clinically definite multiple sclerosis and had had at least two clinical assessments with a time interval of 2-5 years. The rate of deterioration was significantly higher on the MSIS than on the EDSS. The annualized change in EDSS exhibited a maximum at

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Moreira Ferreira, Vanessa F., Danielle Caefer, Natalie Erlich-Malona, Brian C. Healy, Tanuja Chitnis, and James M. Stankiewicz. "Teriflunomide Safety and Efficacy in Advanced Progressive Multiple Sclerosis." Multiple Sclerosis International 2020 (December 17, 2020): 1–7. http://dx.doi.org/10.1155/2020/5471987.

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Objectives. To explore the safety and efficacy profile of teriflunomide in progressive multiple sclerosis. Methods. We conducted a single-center retrospective observational analysis of a progressive multiple sclerosis population, assessing safety and efficacy in patients treated at least one year with teriflunomide or glatiramer acetate. Sustained progression of expanded disability status scale and sustained worsening of timed 25-foot walk were compared using a Cox proportional hazards model. Results. Teriflunomide group ( n = 29 ) mean characteristics: age = 58 years ( SD ± 7.6 ), disease dur

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Barreiro-González, Antonio, Maria T. Sanz, Sara Carratalà-Boscà, et al. "Design and Validation of an Expanded Disability Status Scale Model in Multiple Sclerosis." European Neurology 85, no. 2 (2021): 112–21. http://dx.doi.org/10.1159/000519772.

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<b><i>Introduction:</i></b> We aimed to develop and validate an Expanded Disability Status Scale (EDSS) model through clinical, optical coherence tomography (OCT), and magnetic resonance imaging (MRI) measures. <b><i>Methods:</i></b> Sixty-four multiple sclerosis (MS) patients underwent peripapillary retinal nerve fiber layer and segmented macular layers evaluation through OCT (Spectralis, Heidelberg Engineering). Brain parenchymal fraction was quantified through Freesurfer, while cervical spinal cord (SC) volume was assessed manually guided by S

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Fisniku, LK, DR Altmann, M. Cercignani, et al. "Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosis." Multiple Sclerosis Journal 15, no. 6 (2009): 668–77. http://dx.doi.org/10.1177/1352458509103715.

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Background In multiple sclerosis, grey matter (GM) damage appears more clinically relevant than either white matter damage or lesion load. Objective We investigated if normal-appearing white matter (NAWM) and grey matter tissue changes assessed by magnetization transfer ratio were associated with long-term disability. Methods Sixty-nine people were assessed 20 years after presentation with a clinically isolated syndrome (CIS) [28 still CIS, 31 relapsing-remitting multiple sclerosis, 10 secondary progressive multiple sclerosis], along with 19 healthy subjects. Mean magnetization transfer ratio,

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Dujmovic, Irena, Simon Demetz, Alban Millonig, and Florian Deisenhammer. "The effect of fatigability on expanded disability status scale components in multiple sclerosis." Srpski arhiv za celokupno lekarstvo 144, no. 5-6 (2016): 262–65. http://dx.doi.org/10.2298/sarh1606262d.

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Introduction. The Expanded Disability Status Scale (EDSS) is the most widely used disability measure in multiple sclerosis (MS). The effect of fatigability on EDSS components has been underreported to date. Objective We investigated daytime variability in EDSS score and EDSS components - functional scores (FS) and walking distance (WD) up to 500 m, in MS patients who underwent a standardized fatiguing exercise. Methods. Twenty-four patients with relapsing-remitting MS (n = 7), secondary-progressive MS (n = 8) and primary-progressive MS (n = 9) were included. Exclusion criteria were as follows:

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Harati Kabir, Vida, Rasoul Mahdavifar Khayati, Ali Motie Nasrabadi, and Seyed Massood Nabavi. "Prediction of Expanded Disability Status Scale in patients with MS using deep learning." Computers in Biology and Medicine 182 (November 2024): 109143. http://dx.doi.org/10.1016/j.compbiomed.2024.109143.

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Laptikultham, S. L., and P. D. Dusitanond. "PO10-TU-74 Simplified expanded disability status scale (EDSS) table and multiple sclerosis." Journal of the Neurological Sciences 285 (October 2009): S216. http://dx.doi.org/10.1016/s0022-510x(09)70823-8.

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Cao, Hua, Laurent Peyrodie, Olivier Agnani, Fabrice Cavillon, Patrick Hautecoeur, and Cécile Donzé. "Evaluation of an Expanded Disability Status Scale (EDSS) modeling strategy in multiple sclerosis." Medical & Biological Engineering & Computing 53, no. 11 (2015): 1141–51. http://dx.doi.org/10.1007/s11517-015-1383-7.

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Hubbard, Elizabeth A., and Robert W. Motl. "Sedentary behavior is associated with disability status and walking performance, but not cognitive function, in multiple sclerosis." Applied Physiology, Nutrition, and Metabolism 40, no. 2 (2015): 203–6. http://dx.doi.org/10.1139/apnm-2014-0271.

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Eighty-two persons with multiple sclerosis wore an accelerometer as a measure of sedentary time (min/day) and completed measures of disability status (self-reported Expanded Disability Status Scale), walking performance (timed 25-foot walk and 6-min walk), and cognitive function (symbol digit modalities test). Accelerometry-measured sedentary time was significantly correlated with disability status scores (r = 0.31, p < 0.01), 6-min walk distance (r = –0.40, p < 0.01), and timed 25-foot walk performance (r = 0.35, p < 0.01), but not cognitive function performance (r = –0.12, p = 0.29)

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Baldassari, Laura E., Amber R. Salter, Erin E. Longbrake, Anne H. Cross, and Robert T. Naismith. "Streamlined EDSS for use in multiple sclerosis clinical practice: Development and cross-sectional comparison to EDSS." Multiple Sclerosis Journal 24, no. 10 (2017): 1347–55. http://dx.doi.org/10.1177/1352458517721357.

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Background: The Expanded Disability Status Scale (EDSS) is the standard measure of disability in multiple sclerosis clinical trials. The EDSS has limited application in the clinical setting due to required completion time and scoring complexity. Systematically recording an objective, simplified, less time-intensive, and neurologist-derived disability score would be beneficial for patient care. Objective: To develop and validate a streamlined version of the Expanded Disability Status Scale (sEDSS) for clinical monitoring. Methods: The EDSS was modified by eliminating maneuvers with no impact on

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Cerea, Silvia, Marta Ghisi, Marco Pitteri, et al. "Coping Strategies and Their Impact on Quality of Life and Physical Disability of People with Multiple Sclerosis." Journal of Clinical Medicine 10, no. 23 (2021): 5607. http://dx.doi.org/10.3390/jcm10235607.

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The aim of the study is to investigate the impact of coping strategies on Health-Related Quality of Life (HRQoL) and physical disability assessed with the Expanded Disability Status Scale (EDSS) of people with multiple sclerosis (pwMS). PwMS were asked to focus on “MS diagnosis” as the core stressor. One hundred eight pwMS completed the Coping Responses Inventory-Adult form (CRI-Adult), the Multiple Sclerosis Quality of Life-29 (MSQoL-29), and the Depression Anxiety Stress Scale-21 (DASS-21). Multiple regression analyses (first block: EDSS, disease duration, and DASS-21) revealed that physical

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Shulga, O. D. "PREDICTION OF MULTIPLE SCLEROSIS COURSE: RESULTS OF PROSPECTIVE STUDY." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 1 (2020): 126–29. http://dx.doi.org/10.31718/2077-1096.20.1.126.

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Background: The course of multiple sclerosis is variable and unpredictable. Despite considerable efforts and research over the decades, one of the major challenges for both neurologists and patients is still to determine the prognosis of multiple sclerosis as well as the factors and markers affecting its progression. Prospective studies can partially contribute to assessment of the factors predetermining the prognosis of the course of multiple sclerosis. Objective: To evaluate the factors affecting the course of multiple sclerosis according to a 5-year prospective dynamic observation.&#x

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Huda, S., A. Cavey, A. Izat, P. Mattison, M. Boggild, and J. Palace. "Nurse led telephone assessment of expanded disability status scale assessment in MS patients at high levels of disability." Journal of the Neurological Sciences 362 (March 2016): 66–68. http://dx.doi.org/10.1016/j.jns.2016.01.011.

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Füvesi, Judit. "Az Expanded Disability Status Scale használata és a motoros képességek vizsgálata sclerosis multiplexes betegekben." Ideggyógyászati szemle 72, no. 9-10 (2019): 317–23. http://dx.doi.org/10.18071/isz.72.0317.

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Alonso, Ricardo N., Maria B. Eizaguirre, Berenice Silva, et al. "Brain Function Assessment of Patients with Multiple Sclerosis in the Expanded Disability Status Scale." International Journal of MS Care 22, no. 1 (2020): 31–35. http://dx.doi.org/10.7224/1537-2073.2018-084.

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Abstract Background: There is no consensus regarding assessment of the brain function functional system (FS) of the Expanded Disability Status Scale (EDSS) in patients with multiple sclerosis (MS). We sought to describe brain function FS assessment criteria used by Argentinian neurologists and, based on the results, propose redefined brain function FS criteria. Methods: A structured survey was conducted of 113 Argentinian neurologists. Considering the survey results, we decided to redefine the brain function FS scoring using the Brief International Cognitive Assessment for MS (BICAMS) battery.

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Bovis, Francesca, Alessio Signori, Luca Carmisciano, et al. "Expanded disability status scale progression assessment heterogeneity in multiple sclerosis according to geographical areas." Annals of Neurology 84, no. 4 (2018): 621–25. http://dx.doi.org/10.1002/ana.25323.

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Brass, Steven D., Sridar Narayanan, Jack P. Antel, Yves Lapierre, Louis Collins, and Douglas L. Arnold. "Axonal Damage in Multiple Sclerosis Patients with High versus Low Expanded Disability Status Scale Score." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 31, no. 2 (2004): 225–28. http://dx.doi.org/10.1017/s0317167100053877.

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AbstractBackground:The pathophysiological basis for differences in disability in patients with multiple sclerosis is unclear.Methods:We used magnetic resonance imaging to examine whether differences in disability in cohorts of multiple sclerosis patients with similar T2-weighted lesion volume and disease duration were associated with a more destructive disease process in the more disabled patients.Results:The benign and severely disabled groups had similar brain atrophy metrics and similar decreases of the neuronal marker, N-acetylaspartate, in the normal appearing white matter of the cerebrum

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Gärtner, Jutta, Wolfgang Brück, Almuth Weddige, Hannah Hummel, Christiane Norenberg, and Jörg-Peter Bugge. "Interferon beta-1b in treatment-naïve paediatric patients with relapsing–remitting multiple sclerosis: Two-year results from the BETAPAEDIC study." Multiple Sclerosis Journal - Experimental, Translational and Clinical 3, no. 4 (2017): 205521731774762. http://dx.doi.org/10.1177/2055217317747623.

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Background and objective Study evaluating Betaferon(R)'s safety and tolerability in paediatric patients with multiple sclerosis (BETAPAEDIC) is a prospective, open-label observational multicentre study to assess the safety and effectiveness of interferon beta-1b in paediatric patients with relapsing–remitting multiple sclerosis. Methods Treatment-naïve patients (12–16 years) scheduled to start interferon beta-1b were enrolled with follow-up visits every six months for two years. Effectiveness was evaluated by annualised relapse rate, Expanded Disability Status Scale progression, cranial magnet

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Brownlee, Wallace J., Dan R. Altmann, Ferran Prados, et al. "Early imaging predictors of long-term outcomes in relapse-onset multiple sclerosis." Brain 142, no. 8 (2019): 2276–87. http://dx.doi.org/10.1093/brain/awz156.

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Abstract The clinical course of relapse-onset multiple sclerosis is highly variable. Demographic factors, clinical features and global brain T2 lesion load have limited value in counselling individual patients. We investigated early MRI predictors of key long-term outcomes including secondary progressive multiple sclerosis, physical disability and cognitive performance, 15 years after a clinically isolated syndrome. A cohort of patients with clinically isolated syndrome (n = 178) was prospectively recruited within 3 months of clinical disease onset and studied with MRI scans of the brain and s

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Čelan, Nastasja, Dušan Čelan, and Breda Jesenšek Papež. "Comparison of the expanded disability status scale and the functional independence measure in patients with multiple sclerosis." Acta Medico-Biotechnica 15, no. 2 (2023): 26–32. http://dx.doi.org/10.18690/actabiomed.239.

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Objective: This study aimed to evaluate scales that are used to follow up on the condition and course of rehabilitation for an objective assessment of patients with multiple sclerosis. The most commonly used scale is the Expanded Disability Status Scale (EDSS) for obtaining information on neurological impairments. The main disadvantage of this scale is that it focuses a lot on the ability to walk and is not adequately sensitive for detecting the changes in the patient in time. The Functional Independence Measure (FIM) is the most commonly used scale in rehabilitation. It evaluates the ability

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Ertem, Uğur. "Comment on "Long-term disability in multiple sclerosis: a longitudinal study over 20 years"." Cukurova Medical Journal 49, no. 4 (2024): 1129–30. https://doi.org/10.17826/cumj.1394631.

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In this article, I would like to share my ideas about the publication "Long-term disability in multiple sclerosis: a longitudinal study over 20 years" and evaluate the disability in patients diagnosed with multiple sclerosis (MS) from a physiatrist's perspective. In the current study, it was concluded that a high initial Expanded Disability Status Scale (EDSS) score in MS patients, lack of full recovery after the first attack, and a longer period between attacks may provide insight into predicting long-term disability.

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Togha, Mansoureh, Sanaz Ahmadi Karvigh, Masoud Nabavi, et al. "Simvastatin treatment in patients with relapsing-remitting multiple sclerosis receiving interferon beta 1a: a double-blind randomized controlled trial." Multiple Sclerosis Journal 16, no. 7 (2010): 848–54. http://dx.doi.org/10.1177/1352458510369147.

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Objectives: This study was conducted to evaluate the effect of simvastatin (40 mg/day) as an adjuvant therapy to interferon beta (IFNb 1a, 30 µg once weekly) in relapsing—remitting multiple sclerosis patients, compared with placebo. Methods: We enrolled 85 patients with relapsing—remitting multiple sclerosis (71% female) who were already receiving IFNb 1a (Avonex), with Expanded Disability Status Scale score of less than 5.0. The patients were assigned (in random and double-blinded fashion) into the two groups of simvastatin and placebo. All patients continued to receive their current IFNb tre

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Tanovic, Edina, Dževad Vrabac, Aldijana Kadić, Admir Rama, and Haris Tanović. "Evaluation of the treatment efficacy of patients with multiple sclerosis using Barthel index and Expanded Disability Status Scale." Journal of Health Sciences 4, no. 2 (2014): 110–13. http://dx.doi.org/10.17532/jhsci.2014.202.

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Introduction: Multiple sclerosis (MS) is a chronic, autoimmune and progressive multifocal demyelinating disease of the central nervous system. The aim of this study was to evaluate rehabilitation of patients with multiple sclerosis using BI (Barthel index) and EDDS (Expanded Disability Status Scale).Methods: A clinical observational study was made at the clinic for physical medicine and rehabilitation in Sarajevo. We analyzed 49 patients with MS in relation of gender, age and level of disability at admission and discharge, patient disability were estimated using EDDS scale. The ability of pati

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Smolders, Joost. "Vitamin D and Multiple Sclerosis: Correlation, Causality, and Controversy." Autoimmune Diseases 2011 (2011): 1–3. http://dx.doi.org/10.4061/2011/629538.

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The last years, many studies reported associations between correlates of vitamin D exposure and several correlates of multiple sclerosis (MS) disease activity. This review discusses studies on vitamin D status, Expanded Disability Status Scale (EDSS) score, and relapse activity of MS. Furthermore, several considerations for intervention studies on vitamin D supplementation in MS are provided.

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Sola, Patrizia, Jessica Mandrioli, Anna M. Simone, et al. "Primary progressive versus relapsing-onset multiple sclerosis: presence and prognostic value of cerebrospinal fluid oligoclonal IgM." Multiple Sclerosis Journal 17, no. 3 (2010): 303–11. http://dx.doi.org/10.1177/1352458510386996.

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Background: There is increasing evidence on cerebrospinal fluid (CSF) oligoclonal IgM (OCIgM) predicting a more aggressive disease course in relapsing–remitting Multiple Sclerosis (MS), while there is a scarcity of data for primary progressive MS (PPMS). Objective: Our aim was to investigate the presence and possible prognostic value of CSF OCIgM in a group of PPMS and in a group of relapsing-onset MS patients. The possible prognostic role of other clinical and biological factors was also evaluated. Methods: We calculated the impact of single clinical and biological factors, including CSF OCIg

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Janssens, A. CJW, P. A. van Doorn, J. B. de Boer, et al. "A nxiety and depression influence the relation between disability status and quality of life in multiple sclerosis." Multiple Sclerosis Journal 9, no. 4 (2003): 397–403. http://dx.doi.org/10.1191/1352458503ms930oa.

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Disability status, depression and anxiety are important determinants of quality of life (Q oL) in patients with multiple sclerosis (MS). We investigated whether anxiety and depression influence the relation between disability status and Q oL in our cohort of recently diagnosed patients. Disability status [Expanded Disability Status Scale (EDSS)], anxiety and depression [Hospital A nxiety and Depression Scale (HADS)], and Q oL (SF-36) were prospectively obtained in 101 MS patients. The relation between EDSS and SF-36 scales was examined using regression analyses, without and with adjustment for

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Rabadi, Meheroz H., and Andrea S. Vincent. "Comparison of the Kurtkze Expanded Disability Status Scale and the Functional Independence Measure: measures of multiple sclerosis-related disability." Disability and Rehabilitation 35, no. 22 (2013): 1877–84. http://dx.doi.org/10.3109/09638288.2013.766269.

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Asvar, Soodabeh, and Farzaneh Taghian. "The Effect of an Eight-week Pilates Training on Interleukine-18 Level, Fatigue, and Balance in Women With Multiple Sclerosis." Journal of Research & Health 10, no. 6 (2020): 383–92. http://dx.doi.org/10.32598/jrh.10.6.552.4.

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Background: Proinflammatory cytokines increasingly cause inflammation in patients with Multiple Sclerosis (MS). In this regard, the current study aimed to shed light on the effectiveness of an eight-week Pilates training program in the level of interleukin-18, the severity of fatigue, balance, and physical disability, in females with MS. Methods: This study was a quasi-experimental research with a pre-test-post-test design and a control group and conducted in Sirjan City, Iran. A total of 30 female MS patients (Mean±SD age: 30.15±6.97 years; 2≤ expanded disability status scale≤5.5) were select

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Asvar, Soodabeh, and Farzaneh Taghian. "The Effect of an Eight-week Pilates Training on Interleukine-18 Level, Fatigue, and Balance in Women With Multiple Sclerosis." Journal of Research & Health 10, no. 6 (2020): 383–92. http://dx.doi.org/10.32598/jrh.10.6.552.4.

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Background: Proinflammatory cytokines increasingly cause inflammation in patients with Multiple Sclerosis (MS). In this regard, the current study aimed to shed light on the effectiveness of an eight-week Pilates training program in the level of interleukin-18, the severity of fatigue, balance, and physical disability, in females with MS. Methods: This study was a quasi-experimental research with a pre-test-post-test design and a control group and conducted in Sirjan City, Iran. A total of 30 female MS patients (Mean±SD age: 30.15±6.97 years; 2≤ expanded disability status scale≤5.5) were select

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