Relevant bibliographies by topics / Experimental animals - Medicine

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Experimental animals - Medicine'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Journal articles on the topic "Experimental animals - Medicine"

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Niczyporuk, M. "Rat skin as an experimental model in medicine." Progress in Health Sciences 8, no. 2 (2018): 223–28. http://dx.doi.org/10.5604/01.3001.0012.8351.

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Scientific experiments due to safety and ethical limitations regarding research human are often based on animal models. Rats are laboratory animals which are commonly used for these purposes. It should be remembered that morphologi- cal and functional differences between rat skin and human skin may refer to the correct interpretation of scientific results.
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Bellavite, Paolo, Riccardo Ortolani, and Anita Conforti. "Immunology and Homeopathy. 3. Experimental Studies on Animal Models." Evidence-Based Complementary and Alternative Medicine 3, no. 2 (2006): 171–86. http://dx.doi.org/10.1093/ecam/nel016.

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A search of the literature and the experiments carried out by the authors of this review show that there are a number of animal models where the effect of homeopathic dilutions or the principles of homeopathic medicine have been tested. The results relate to the immunostimulation by ultralow doses of antigens, the immunological models of the ‘simile’, the regulation of acute or chronic inflammatory processes and the use of homeopathic medicines in farming. The models utilized by different research groups are extremely etherogeneous and differ as the test medicines, the dilutions and the outcomes are concerned. Some experimental lines, particularly those utilizing mice models of immunomodulation and anti-inflammatory effects of homeopathic complex formulations, give support to a real effect of homeopathic high dilutions in animals, but often these data are of preliminary nature and have not been independently replicated. The evidence emerging from animal models is supporting the traditional ‘simile’ rule, according to which ultralow doses of compounds, that in high doses are pathogenic, may have paradoxically a protective or curative effect. Despite a few encouraging observational studies, the effectiveness of the homeopathic prevention or therapy of infections in veterinary medicine is not sufficiently supported by randomized and controlled trials.
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CASSIDY, ANGELA, RACHEL MASON DENTINGER, KATHRYN SCHOEFERT, and ABIGAIL WOODS. "Animal roles and traces in the history of medicine,c.1880–1980." BJHS Themes 2 (2017): 11–33. http://dx.doi.org/10.1017/bjt.2017.3.

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AbstractThis paper argues for the need to create a more animal-centred history of medicine, in which animals are considered not simply as the backdrop for human history, but as medical subjects important in and of themselves. Drawing on the tools and approaches of animal and human–animal studies, it seeks to demonstrate, via four short historical vignettes, how investigations into the ways that animals shaped and were shaped by medicine enables us to reach new historical understandings of both animals and medicine, and of the relationships between them. This is achieved by turning away from the much-studied fields of experimental medicine and public health, to address four historically neglected contexts in which diseased animals played important roles: zoology/pathology, parasitology/epidemiology, ethology/psychiatry, and wildlife/veterinary medicine. Focusing, in turn, on species that rarely feature in the history of medicine – big cats, tapeworms, marsupials and mustelids – which were studied, respectively, within the zoo, the psychiatric hospital, human–animal communities and the countryside, we reconstruct the histories of these animals using the traces that they left on the medical-historical record.
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Dubner, R. "Experimental neuropathies in animals." Pain 30 (1987): S207. http://dx.doi.org/10.1016/0304-3959(87)91486-2.

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de Boo, Jasmijn, and Coenraad Hendriksen. "Reduction Strategies in Animal Research: A Review of Scientific Approaches at the Intra-experimental, Supra-experimental and Extra-experimental Levels." Alternatives to Laboratory Animals 33, no. 4 (2005): 369–77. http://dx.doi.org/10.1177/026119290503300404.

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When discussing animal use and considering alternatives to animals in biomedical research and testing, the number of animals required gets to the root of the matter on ethics and justification. In this paper, some reduction strategies are reviewed. Many articles and reports on reduction of animal use focus mostly on the experimental level, but other approaches are also possible. Reduction at the intra-experimental level probably offers the greatest scope for reduction, as the design and statistical analysis of individual experiments can often be improved. Supra-experimental reduction aims to reduce the number of animals by a change in the setting in which a series of experiments take place — for example, by improved education and training, reduction of breeding surpluses, critical analysis of test specifications, and re-use of animals. At the extra-experimental level, reduction is a spin-off of other developments, rather than the direct goal. Through improved research or production strategies, aimed at better quality, consistency and safety, reduction in the number of animals used can be substantial. A revised definition of reduction is proposed, which does not include the level of information needed, as in some cases reduction in the number of animals resulting in less information or data, is still acceptable.
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Wolfman, David E., and Richard A. Chole. "Experimental Retraction Pocket Cholesteatoma." Annals of Otology, Rhinology & Laryngology 95, no. 6 (1986): 639–44. http://dx.doi.org/10.1177/000348948609500619.

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An animal model for retraction pocket (primary acquired) cholesteatoma is presented. Bilateral eustachian tube obstruction by electrocauterization of the nasopharyngeal portion was performed in 16 Mongolian gerbils. Animals were killed at 2, 4, 8, and 16 weeks. At 2 weeks all animals had bilateral serous effusions and retracted tympanic membranes. At 4 weeks, four of eight ears had middle ear fluid, retractions, and cholesteatomas. After 8 weeks, five of eight ears had middle ear effusions, and four of these had cholesteatomas; one ear had total atelectasis with a cholesteatoma filling the bulla. By 16 weeks, six of eight ears had developed cholesteatomas. Some animals did not develop effusion or retraction because of failure or recanalization of eustachian tube obstruction. This study provides experimental evidence that aural cholesteatomas may arise by retraction of the tympanic membrane.
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Costa-Neto, Eraldo M. "Animal-based medicines: biological prospection and the sustainable use of zootherapeutic resources." Anais da Academia Brasileira de Ciências 77, no. 1 (2005): 33–43. http://dx.doi.org/10.1590/s0001-37652005000100004.

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Animals have been used as medicinal resources for the treatment and relieve of a myriad of illnesses and diseases in practically every human culture. Although considered by many as superstition, the pertinence of traditional medicine based on animals cannot be denied since they have been methodically tested by pharmaceutical companies as sources of drugs to the modern medical science. The phenomenon of zootherapy represents a strong evidence of the medicinal use of animal resources. Indeed, drug companies and agribusiness firms have been evaluating animals for decades without paying anything to the countries from where these genetic resources are found. The use of animals' body parts as folk medicines is relevant because it implies additional pressure over critical wild populations. It is argued that many animal species have been overexploited as sources of medicines for the traditional trade. Additionally, animal populations have become depleted or endangered as a result of their use as experimental subjects or animal models. Research on zootherapy should be compatible with the welfare of the medicinal animals, and the use of their by-products should be done in a sustainable way. It is discussed that sustainability is now required as the guiding principle for biological conservation.
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Eberhard, M. L., E. Kovacs-Nace, J. Blotkamp, J. J. Verwij, V. A. A. Asigri, and A. M. Polderman. "Experimental Oesophagostomum bifurcum in monkeys." Journal of Helminthology 75, no. 1 (2001): 51–56. http://dx.doi.org/10.1079/joh200031.

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Oesophagostomum bifurcum larvae, cultured from human stools collected in northern Ghana, were used to establish experimental infections in monkeys. A patent infection was established in a rhesus monkey (Macaca mulatta) and this infection was used to generate larvae to inoculate additional monkeys. In all, 17 animals were inoculated. Thirteen of 15 animals developed antibodies to the infection between 19 and 62 days post inoculation (PI); two animals had a positive response before inoculation. Four of ten animals developed patent infections between 88 and 134 days and passed eggs in the faeces. Egg shedding was consistent in only one animal, but at low levels of one or two eggs per 2 mg direct smear, and extended over a 400 day period. In the other three animals, egg shedding was sporadic and of only 2–4 weeks duration. In seven animals necropsied between 19 and 22 days PI, one to 17 early fourth-stage larvae were recovered from nodules in the bowel wall; in an eighth animal examined at 314 days, six immature adult worms (early fifth stage) were recovered from nodules in the bowel wall. The morphological features and growth of these recovered larvae are described. Three animals were inoculated with larvae that had been dried for one week at 28°C; two animals began shedding eggs at 128 and 134 days PI, respectively. The present results suggest that the parasite obtained from humans is poorly adapted to lower primate hosts, and supports the concept that Oesophagostomum bifurcum found in humans and monkeys in the same geographical region of northern Ghana and Togo are distinct and that the infections in humans are not likely to represent zoonotic infections acquired from monkeys.
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Čabaravdić, Amra, Irfan Zulić, Zakira Mornjaković, Mirjana Mijanović, and Fahir Bečić. "Experimental model of the burn wound topical treatment." Bosnian Journal of Basic Medical Sciences 3, no. 4 (2003): 61–66. http://dx.doi.org/10.17305/bjbms.2003.3495.

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AbstractBACKGROUND AND PURPOSE:Clinical research of drugs is a researching step subsequent to the preclinical studies in experimental animals. The aim of our research was to evaluate animal model of wound healing process after the burninducement and effects of the ointment containing natural plants on the process of burn healing.MATERIAL AND METHODS:Burn wounds were experimentally induced in two species of experimental animals which were treated with topically applied herbal preparation with concomitant monitoring of the healing process. Experimental groups (1) of 15 animals each (mice and rats), while control group (2) of 10 animals each (mice and rats) that were not being treated with herbal ointment. After the hair removal, burn was induced on the back of animals by heated brass seal. Different clinical symptoms including oedema of surrounding tissue, redness, exudation, size of the burn surface, histological and microbiological findings were monitored on the days 1, 3, 7, 14 and 21. A statistically significant difference was observed throughout descriptive statistics and paired Student's t-test.CONCLUSION:Physiological healing processes of the acute burn wound following the topical application of herbal preparation can be monitored on the utilized animal model. A three-week treatment resulted in the 90% of completed epithelization in both animal species, indicating the effectiveness of topically applied herbal preparation.
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Telemo, Esbjörn, Malin Karlsson, Anna Dahlman-Höglund, Ulf Dahlgren, and Samuel Lundin. "Oral Tolerance in Experimental Animals." International Archives of Allergy and Immunology 113, no. 1-3 (1997): 219–23. http://dx.doi.org/10.1159/000237552.

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Dissertations / Theses on the topic "Experimental animals - Medicine"

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Van, der Westhuizen Liana. "The effects of fumonisins on sphinganine and sphingosine levels in hepataocyte cultures, experimental animals and humans." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51973.

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Mukinda, James Tshikosa. "Acute and chronic toxicity of the flavonoid-containing plant, Artemisia afra in rodents." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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The aim of this study was to investigate the possible toxicity of the flavonoid-containing plant, Artemisia afra and especially establish the safety of the aqueous extract of this plant after acute and chronic administration to mice and rats respectively.
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朱月華 and Yuet-wah Chu. "The use of a Chinese medicinal formula (Chuan-Duan-Bu-Gu-San) on experimental fracture healing in a mouse model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31227302.

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Bowell, Verity A. "Improving the welfare of laboratory-housed primates through the use of positive reinforcement training : practicalities of implementation." Thesis, University of Stirling, 2010. http://hdl.handle.net/1893/3442.

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Whilst there has been a recent increase in interest in using positive reinforcement training for laboratory-housed primates, there remains a reluctance to put into practice training programmes. Much of this reticence seems to stem from lack of expertise in the running of training programmes, and a perception that training requires a large time investment, with concurrent staff costs. The aim of this thesis was to provide practical recommendations for the use of training programmes in laboratories, providing primate users and carestaff with background information needed to successfully implement training programmes whilst improving the welfare of the animals in their care. Training was carried out with two species, cynomolgus macaques (Macaca fascicularis) and common marmosets (Callithrix jacchus) in three different research laboratories to ensure practicability was as wide ranging as possible. Training success and the time investment required were closely related to the primate's temperament, most notably an individual's willingness to interact with humans, in both common marmosets and cynomolgus macaques. Age and sex however had no effect on an individual's trainability. The training of common marmosets was more successful than that with cynomolgus macaques, possibly due to differences in early experience and socialisation. Positive reinforcement training helped both species to cope with the stress of cage change or cleaning, with the monkeys showing less anxiety-related behaviour following the training programme than before. Involving two trainers in the training process did not affect the speed at which common marmosets learned to cooperate with transport box training, but behavioural observations showed that initial training sessions with a new trainer led to animals experiencing some anxiety. This however was relatively transient. Whilst the training of common marmosets to cooperate with hand capture was possible, there seemed little benefit in doing so as the monkeys did not show a reduced behavioural or physiological stress response to trained capture as compared to hand capture prior to training. However strong evidence was found that following both training and positive human interactions the marmosets coped better with capture and stress was reduced. It is recommended that an increased use of early socialisation would benefit laboratory-housed primates, and would also help improve the success of training. Further, the time investment required shows that training is practicable in the laboratory for both species, and that positive reinforcement training is an important way of improving their welfare likely through reducing boredom and fear.
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Quiggle, David Douglas. "The effects of R-flurbiprofen in reducing tumors in a multiple intestinal neoplasia mouse model." CSUSB ScholarWorks, 2001. https://scholarworks.lib.csusb.edu/etd-project/2009.

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The design of the proposed study was to administer R-FB to 72-day old Min/+ mice for up to 42 days. In order to capture the process of tumor reduction, animals were necropsied at various time points. At each time point animals were evaluated for tumor loads and presence of apoptotic cells along the small intestine. Studies have shown that when R-flurbiprofen (R-FB) is administered in the Min/+ mouse model it can cause the prevention and regression on intestinal tumors.
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Bertti, Rodolfo Otávio Tomaz 1974. "Modelo experimental de obstrução ureteral em coelhos." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310675.

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Orientadores: Marcelo Lopes de Lima, Carlos Arturo Levi D¿Ancona<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T16:54:01Z (GMT). No. of bitstreams: 1 Bertti_RodolfoOtavioTomaz_M.pdf: 2337476 bytes, checksum: aee22920cef52ff73befdaef0207e2f7 (MD5) Previous issue date: 2011<br>Resumo: A estenose da junção pieloureteral (JUP) é uma das anomalias congênitas mais frequentes. Clinicamente, pode se manifestar por infecção do trato urinário, por dor e pela perda da função renal. Portanto, o estudo desta doença é importante para se determinar a melhor forma tratamento. O objetivo deste trabalho foi criar um modelo experimental de estenose ureteral. Dez coelhas da raça New Zealand foram estudadas, com idade de três meses e peso aproximado de 3,5kg. Através de laparotomia e abordagem do retroperitôneo, um segmento do ureter esquerdo foi introduzido no músculo psoas ipsilateral de forma padronizada. O lado direto funcionou como controle. Um mês após a cirurgia, os animais foram submetidos a estudo renal cintilográfico com o ácido dietilenotriaminopentacético marcado com 99mTc (DTPA-99mTc). Em seguida, os animais foram submetidos à eutanásia e as peças (rins e ureteres) retiradas para análise histológica. O estudo cintilográfico demonstrou que sete unidades renais esquerdas apresentaram padrão de obstrução ureteral. A porcentagem de excreção após a administração de furosemida variou de 1 +/- 74% para DTPA-99mTc, apresentando uma diferença estatisticamente significante (p<0,05). No estudo anatomopatológico, concluiu-se que os rins e ureteres mantinham hidronefroses leves em dois e moderadas em sete animais, caracterizando diagnóstico de obstrução em nove coelhas (90%). Houve, também, discreto processo inflamatório e ausência de fibrose no segmento ureteral introduzido no músculo psoas. A técnica experimental de obstrução ureteral criou um modelo de hidronefrose em coelhos<br>Abstract: The stenosis of the ureteropelvic junction (UPJ) is one of the most frequent congenital anomalies and are clinically important to be treated not only for the quality of life that gets worse, pain and urinary tract infection, but also the loss of the kidney function (1,2,3). So, the study of UPJ model will be used for future treatment. The aim of this study was to create an experimental model of ureteral obstruction in rabbits. The sample of this project was composed by a number of ten female rabbits from New Zealand, three months old, weighing about 3.5kg. An intra-peritoneal medium laparatomy was made, pushing the abdominal organs in order to have a large access to the retroperitoneal. The studies consist of creating an experimental ureteral obstruction model through the introduction of its segment inside the psoas ipsilateral muscle in a standard way. The right side was used as the control. After one month, the rabbits were underwent the intravenous injection of 99mTc-DTPA. After the diuretic renogram analysis was realized, the animal was sacrificed end the removed parts, kidneys and ureters were submited histological analysis. The study showed that seven left kidneys presented obstruction. The excretion after furosemide injection was 1 ± 74% for 99mTc-DTPA, with a statistically significant difference between both renal (p<0.05). In the anatomopathological study, two animals were classified as light and seven as moderate obstruction, characterizing diagnosis of obstruction in nine rabbits (90%). The lack of an inflammatory process and fibrosis in the circumvolution location was observed. The experimental technique of ureteral obstruction created a model of hydronephrosis in rabbits<br>Mestrado<br>Cirurgia<br>Mestre em Cirurgia
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Humphries, Petro. "Effects of aspartame on the blood coagulation system of the rabbit." Thesis, University of Pretoria, 2007. http://upetd.up.ac.za/thesis/available/etd-05162008-162042.

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Qasim, Faieza Jabeen. "Study of an animal model of experimental vasculitis." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361670.

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Cano, Garrido Olivia. "Production of protein nanomaterials in lactic acid bacteria for human and animal medicine." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/392682.

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Tot i que Escherichia coli és el bacteri més àmpliament usat en el camp de la producció de proteïnes recombinants, aquest conté lipopolisacàrids (LPS) en la seva membrana externa. Com a conseqüència de la presència d’aquest contaminant bacterià, el potencial dels productes proteics produïts amb finalitats mèdiques en aquest microorganisme Gram-negatiu es veu severament limitat. En aquest context, els bacteris de l’àcid làctic (BAL), un grup de microorganismes Gram-positius, han anat guanyant importància com a alternativa per la producció de proteïnes recombinants segures. Els BAL, que no contenen endotoxines, són àmpliament reconeguts pel seu ús en la indústria alimentària, i a més a més, han estat classificats com organismes “Generally Recognized As Safe” (GRAS) per part de les agències reguladores. Tanmateix, durant les últimes dècades, diverses eines han estat desenvolupades per millor els sistemes d’expressió proteics GRAS, amb l’objectiu de sintetitzar proteïnes heteròlogues lliures de toxines , la majoria d’aquetes utilitzant el bacteri Lactococcus lactis. Les proteïnes recombinants solubles s’associen normalment a una elevada inestabilitat i a alts costos associats als processos de producció i purificació, esdevenint econòmicament inviables pel desenvolupament de productes comercials basats en proteïnes per medicina humana i, molt especialment, per medicina animal. Contràriament, l’ús de proteïnes heteròlogues en forma de nanopartícules amiloides biològicament actives, s’ha presentat com una alternativa rentable i estable. Estudis recents evidencien l’enorme potencial d’aquestes nanopartícules proteiques en l’àmbit de la nanomedicina. No obstant, tot i el seu potencial, aquestes nanopartícules han estat bàsicament produïdes en E.coli i, fins al moment, la seva producció no ha estat explorada en BAL. A més a més, la seva ultraestructura no s’ha estudiat en detall, essent una important tasca que encara queda per resoldre. Així doncs, en aquest estudi, hem descrit l’organització supramolecular d’aquestes nanopartícules composades alhora per proteïnes en estat amiloide i natiu. D’altra banda, hem dut a terme el desenvolupament d’una metodologia per tal de produir materials proteics econòmics, segurs i funcionals mitjançant una plataforma de producció lliure de LPS. Concretament, s’ha utilitzat L. Lactis per tal de produir aquestes nanoestructures proteiques recombinants amb rellevància en medicina humana i animal. Així mateix, s’han determinat també les propietats fisicoquímiques d’aquestes nanopartícules fent ús d’una amplia varietat de tècniques. A grans trets, degut a característiques com la seva activitat biològica, estabilitat, versatilitat i seguretat, aquestes nanopartícules proteiques esdevenen un material prometedor per finalitats terapèutiques.<br>Despite Escherichia coli is the workhouse for recombinant protein production purposes, this bacterial species contains lipopolysaccharide (LPS) in its outer membrane. Consequently, the presence of bacterial endotoxic contaminants severely restricts the potential medical applications of protein goods produced in this Gram-negative microorganism. In this context, lactic acid bacteria (LAB), a group of Gram-positive microorganisms, has been gaining momentum as an alternative for the production of safe recombinant proteins. LAB, which lack endotoxins, are widely well-known by their use in the food industry and are generally recognized as safe (GRAS) organisms by regulatory agencies. Interestingly, during the last decades, many tools have been developed using these food-grade expression systems with the aim to synthesise heterologous proteins, most of them being developed in Lactococcus lactis. Recombinant soluble proteins are often associated to instability and high production and purification costs, being not economically viable for the development of protein-based commercial products for human, but specially, for animal medicine. In this regard, the use of heterologous proteins in form of biologically active amyloidal nanoparticles has been shown to be a cost-effective and stable alternative. Concomitantly, recent studies evidence the enormous potential of these protein-based nanoparticles in nanomedicine. Nevertheless, despite its potential, protein nanoparticles have essentially been produced in E. coli and they have never been described as LAB products. Besides, their ultrastructure has not been studied in detail, remaining as an unsolved task. Thus, in the present study, we have further described the supramolecular organization of these protein nanoparticles composed by both amyloid-like and native-like proteins. On the other side, we have developed a methodology to produce inexpensive, safe, and functional protein-based materials in a LPS-free production platform. Specially, we have used L. lactis to produce nanostructured recombinant proteins relevant for human and animal medicine. Besides, we have also determined the physico-chemical properties of such nanoparticles using a wide variety of techniques. Altogether, the biological functionality, stability, safety, and te versatility of the platform, make these protein-only nanoparticles a very promising material for therapeutic purposes.
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Arantes, Luciana Mendonça [UNESP]. "Treinamento aeróbio e diabetes experimental em ratos: perfil endócrino-metabólico no cerebelo." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/108749.

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Made available in DSpace on 2014-08-13T14:50:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-12-09Bitstream added on 2014-08-13T18:00:04Z : No. of bitstreams: 1 000767302.pdf: 2281403 bytes, checksum: 6c826da6f0200dd44f072f48274cb6cc (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O presente estudo foi delineado para avaliar os efeitos do treinamento físico aeróbio no perfil endócrino-metabólico de ratos diabéticos, com maior ênfase no tecido cerebelar. Para tanto, ratos adultos da linhagem Wistar foram submetidos à aplicação com aloxana monoidratada Sigma (32 mg/kg de peso corporal). Cinco dias após a administração da droga, será realizado um teste de glicemia para comprovação do estado diabético dos animais, sendo considerados diabéticos apenas aqueles ratos que apresentarem glicemia igual ou superior a 250 mg por 100 ml de sangue. Após a constatação do diabetes, os ratos foram distribuídos, aleatoriamente, em quatro grupos: Controle Sedentário (CS) - ratos controles que não realizarão exercícios físicos; Controle Treinado (CT)- ratos controles que serão submetidos ao protocolo de exercícios físicos; Diabéticos Sedentários (DS) - ratos diabéticos aloxânicos que não serão submetidos ao protocolo de exercícios físicos; Diabéticos Treinados (DT) - ratos diabéticos aloxânicos que serão submetidos ao mesmo protocolo de exercícios físicos do grupo controle treinado (CT). O protocolo de treinamento físico consistirá de natação por 1 hora/dia, 5 vezes/semana, durante 8 semanas consecutivas e com sobrecarga, atada ao tórax, correspondente à máxima fase estável de lactato, em % do peso corporal. Os valores de glicemia e trigliceridemia foram aumentados nos animais diabéticos (DS e DT) e ambos foram reduzidos no grupo diabético treinado quando comparados aos valores do grupo diabético sedentário. A indução do diabetes reduziu os valores de insulinemia nos animais de ambos os grupos (DS e DT) e o treinamento físico não alterou os valores deste parâmetro. O treinamento aeróbio não modifica as concentrações de IGF-1 e Insulina no cerebelo. Foi observado diferenças no equilíbrio corporal de ratos diabéticos e controles. O grupo diabético apresentou menor desempenho que.<br>This study had been designed to evaluate the aerobic exercise training effects on endocrine- metabolic profile of diabetic rats, with greater emphasis in the cerebellum. Therefore, adult Wistar rats had been submitted to induction by injecting alloxan monohydrate. Five days after the drug administration, a blood glucose test was performed for proving the glucose diabetic state of the animals, being considered diabetic only those rats which had shown blood glucose equal or higher than 250 mg per 100 ml of blood. After the finding of diabetes, the rats were divided randomly into four groups: Sedentary Control (SC) - control rats which did not engage in physical exercise; Trained Control (TC) - control rats which were submitted to the physical exercise protocol; Sedentary Diabetic (SD) - alloxan diabetic rats which were not submitted to the physical exercise protocol; Trained Diabetic (TD) - alloxan diabetic rats that were submitted to the same physical exercise protocol group of the trained control group (TC). The physical exercise training protocol had been consisted of swimming for 1 hour / day, 5 times / week during 8 consecutive weeks and with an overload, attached to the chest, corresponding to the maximum lactate steady state, in % of the body weight. The values of the blood glucose and triglycerides were increased in diabetic animals (SD and TD) and both were reduced in the trained diabetic group when compared to the sedentary diabetic group values. The inducing of diabetes reduced the insulin values in the animals of both groups (SD and TD), and the physical exercise training has not changed the values of this parameter. The aerobic training did not affect the concentrations of IGF-1 and insulin in the cerebellum. Differences had been observed in the body balance of the diabetic rats and control group. The diabetic group had shown lower performance than the control group, presenting greater difficulty in the activities that require...
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Books on the topic "Experimental animals - Medicine"

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International Workshop on Immune-Deficient Animals. (6th 1988 Peking, China). Immune-deficient animals in experimental medicine. Edited by Wu Bing-quan 1930- and Zheng Jie. Karger, 1989.

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1930-, Wu Bing-quan, and Zheng Jie, eds. Immune-deficient animals in experimental medicine. Karger, 1989.

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International Workshop on Immune-Deficient Animals (6th 1988 Beijing, China). Immune-deficient animals in experimental medicine. Edited by Wu Bing-quan 1930- and Zheng Jie. Karger, 1989.

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Sargent, William. The year of the crab: Marine animals in modern medicine. W.W. Norton, 1987.

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Allen, Tim. Animal models of disease: January 1988 - January 1995. National Agricultural Library, 1995.

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Allen, Tim. Animal models of disease: January 1988-January 1995. National Agricultural Library, 1995.

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Verhetsel, Ernest. They threaten your health. Nutrition Information Center, 1986.

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Animal hematotoxicology: A practical guide for toxicologists and biomedical researchers. Taylor & Francis, 2008.

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E, Prentice D., and Lewis D. J, eds. Atlas of experimental toxicological pathology. MTP Press, 1987.

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Stephens, Martin L. Alternatives to current uses of animals in research, safety testing, and education: A layman's guide. Humane Society of the United States, 1986.

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Book chapters on the topic "Experimental animals - Medicine"

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Meltzer, Richard S. "Echocardiography in Experimental Myocardial Infarction in Animals." In Developments in Cardiovascular Medicine. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1767-8_7.

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Faulkner, J. A., and S. V. Brooks. "Muscle Fatigue in Old Animals." In Advances in Experimental Medicine and Biology. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1016-5_36.

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Marchand, Sandrine, Nicolas Grégoire, and William Couet. "Pharmacokinetics of Polymyxins in Animals." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-16373-0_7.

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Maoka, Takashi. "Carotenoid Metabolism in Aquatic Animals." In Advances in Experimental Medicine and Biology. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-7360-6_4.

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Maoka, Takashi. "Carotenoid Metabolism in Terrestrial Animals." In Advances in Experimental Medicine and Biology. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-7360-6_5.

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Halper, Jaroslava. "Connective Tissue Disorders in Domestic Animals." In Advances in Experimental Medicine and Biology. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-7893-1_14.

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Yang, Ping, Nisar Ahmed, Shakeeb Ullah, Qiusheng Chen, and Yonghua Zheng. "Features of Telocytes in Agricultural Animals." In Advances in Experimental Medicine and Biology. Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-1061-3_6.

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de Souza, Angela Rico, Bradley Swanson, Jennifer Robertson, Jeremy Bender, John Kappler, and Philippa Marrack. "Some Properties of T Cells in Animals." In Advances in Experimental Medicine and Biology. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0757-4_16.

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Westerhof, Nicolaas, and Gijs Elzinga. "Why Smaller Animals Have Higher Heart Rates." In Advances in Experimental Medicine and Biology. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2946-0_31.

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Al-Dabbagh, Mona, and Simon Dobson. "Infectious Hazards from Pets and Domestic Animals." In Advances in Experimental Medicine and Biology. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-7185-2_18.

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Conference papers on the topic "Experimental animals - Medicine"

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Лепехова, Светлана, Svetlana Lepekhova, Н. Судаков, N. Sudakov, Анастасия Жаркая, and Anastasiya Zharkaya. "Modeling of pathological processes in the experiment-the first step in translational medicine." In Topical issues of translational medicine: a collection of articles dedicated to the 5th anniversary of the day The creation of a department for biomedical research and technology of the Irkutsk Scientific Center Siberian Branch of RAS. INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_58be81ec90ab1.

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The paper discusses the significance of animal experiments and modeling of pathological processes for pre-clinical drug trials, methods of diagnostics and treatment, which correspond to the concept of the first phase of the study in translational medicine. The article provides information on the methodology, legal framework and applications of experimental surgery. The simulation results of dyslipidemia and hypoparathyroidism are given. Simulation of pathology in small laboratory animals is regarded as an integral component of basic and applied biomedical research.
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Zhang, Qizhong, Xusheng Mu, Boling Cai, et al. "Experimental study on the killing effect of 510.6-nm green copper-vapor laser HPD on transplanted tumors in animals." In International Conference on Photodynamic Therapy and Laser Medicine, edited by Junheng Li. SPIE, 1993. http://dx.doi.org/10.1117/12.137034.

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Knyazev, N. A., K. A. Samoilova, N. A. Filatova, and A. A. Galaktionova. "Effect of polychromatic visible light on proliferation of tumor cells under conditions in vitro and in vivo—after implantation to experimental animals." In LASER FLORENCE 2008: Selected Presentations at the International Laser Medicine Congress. American Institute of Physics, 2009. http://dx.doi.org/10.1063/1.3175633.

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Borodin, Evgeniy. "SEARCH FOR POTENTIAL LIGANDS FOR TRPM8 WITH THE HELP OF COMPUTER DESIGN." In XIV International Scientific Conference "System Analysis in Medicine". Far Eastern Scientific Center of Physiology and Pathology of Respiration, 2020. http://dx.doi.org/10.12737/conferencearticle_5fe01d9b2fdca3.97577371.

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A search was carried out for potential ligands to TRPM8 - a representative of the family of cationic channels with a transient receptor potential involved in the development of bronchial hypersensitivity and the occurrence of bronchospasm in response to low temperatures. We used a structural design and molecular docking using the autodock software package (http://autodock.scripps.edu/), which allows automated testing of many potential ligands for TRPM8. Docking was carried out with tyrosine 745 (Y745) amino acid residue as a critical residue for channel sensitivity to menthol, a classic TRPM8 agonist. The selection of potential candidates for the role of drugs intended for the treatment of bronchial cold hyperreactivity using in silico methods can be supplemented by testing their biological activity in vitro experiments with cell and tissue cultures and in vivo with experimental animals.
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Klein, Gabriela, and Gabriella Barcelos. "OZONIOTERAPIA EM DOENÇAS DERMATOLÓGICAS: REVISÃO DE LITERATURA." In I Congresso On-line Nacional de Clínica Veterinária de Pequenos Animais. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1880.

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Introdução: A ozonioterapia consiste na administração de ozônio em diversas formulações em pacientes com o intuito medicinal. O ozônio é um gás que está presente na estratosfera e sua utilização na Medicina Veterinária tem se destacado recentemente. Este gás promove diversos efeitos no organismo, sendo eles, viricida, bactericida, oxidante e fungicida. Apresentando potencial para terapias complementares em diversos quadros, inclusive dermatológicos. Objetivos: Descrever o uso da ozonioterapia e seus benefícios para o tratamento de dermatopatias. Material e métodos: Foi realizada uma revisão bibliográfica de artigos indexados com as palavras-chave: dermatopatias, ozonioterapia e veterinária. Resultados: O uso da ozonioterapia é relatado em diversos quadros de dermatopatias, principalmente em cães e gatos, apesar de poucos estudos controlados existirem, diversos relatos de casos sugerem a eficácia da terapia na medicina veterinária. Em um dos relatos, a ozonioterapia resultou em diminuição de secreção, eliminação de crostas, crescimento total de pelos e resolução do prurido em pacientes com dermatite bacteriana difusa pelo método de “Bag” e insuflação retal. A administração da ozonioterapia pelas mesmas técnicas e associada com forma tópica com óleo de girassol ozonizado mostrou-se eficaz no tratamento de esporotricose, resultando em cicatrização tecidual total da lesão e contribuindo à cura clínica. Em outro relato em paciente felino com esporotricose, tratado com ozonioterapia, observou-se redução de edema. A terapia com ozônio também se mostrou eficaz em auxiliar casos de otite, podendo promover redução da infecção, do prurido e das lesões. Em casos de dermatite psicogênica, a ozonioterapia pode auxiliar na redução do tamanho da lesão e no controle do prurido. O ozônio ainda possui ação imunomoduladora, analgésica e anti-inflamatória, explicando sua contribuição na resolução de casos de prurido. Em estudo experimental, ratos submetidos a queimaduras superficiais apresentaram diminuição relevante das lesões com ozonioterapia, comparando com o grupo controle que não recebeu nenhum tipo de terapia. Conclusão: O uso da ozonioterapia como tratamento complementar de condições dermatológicas têm o potencial de reduzir secreção de feridas, área da ferida, prurido e edema, além de promover cicatrização tecidual e crescimento de pêlos. Portanto, a ozonioterapia pode ser considerada como terapia complementar para dermatites, otites e feridas
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Dagan, Inon, Michal Gabay, and Ofer Barnea. "Fluid Resuscitation: Computer Simulation and Animal Experiments." In 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2007. http://dx.doi.org/10.1109/iembs.2007.4352958.

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Qu, Guijuan, and Xiaoqing Dong. "Study on Reform of Experimental Teaching System of Animal Physiology." In 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016). Atlantis Press, 2017. http://dx.doi.org/10.2991/emcm-16.2017.90.

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Tan, Seng Sing, and Chin Tiong Ng. "Real-time Cardiac Output Measurement Using Heat Exchanger Catheter: An Experimental Animal Study." In Annual International Conferences on Cardiology & Cardiovascular Medicine Research. Global Science & Technology Forum (GSTF), 2014. http://dx.doi.org/10.5176/2382-5669_ccmr14.02.

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Wenyuan Li, Fei Pei, Zhigong Wang, and Xiaoying Lu. "Animal experiments with the microelectronics neural bridge IC." In 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2012. http://dx.doi.org/10.1109/embc.2012.6346058.

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PISANO, PASCALE. "Molecular imaging of experimental stroke : animal models, PET and SPECT radiotacers." In Frontiers in Imaging Science: High Performance Nuclear Medicine Imagers for Vascular Disease Imaging (Brain and Heart). Sissa Medialab, 2008. http://dx.doi.org/10.22323/1.039.0014.

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