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Journal articles on the topic 'Experimental C-peptide Kidney'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Jeson Sangaralingham, S., Denise M. Heublein, Joseph P. Grande, et al. "Urinary C-type natriuretic peptide excretion: a potential novel biomarker for renal fibrosis during aging." American Journal of Physiology-Renal Physiology 301, no. 5 (2011): F943—F952. http://dx.doi.org/10.1152/ajprenal.00170.2011.

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Renal aging is characterized by structural changes in the kidney including fibrosis, which contributes to the increased risk of kidney and cardiac failure in the elderly. Studies involving healthy kidney donors demonstrated subclinical age-related nephropathy on renal biopsy that was not detected by standard diagnostic tests. Thus there is a high-priority need for novel noninvasive biomarkers to detect the presence of preclinical age-associated renal structural and functional changes. C-type natriuretic peptide (CNP) possesses renoprotective properties and is present in the kidney; however, it

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2

Nordquist, Lina, Russell Brown, Angelica Fasching, Patrik Persson, and Fredrik Palm. "Proinsulin C-peptide reduces diabetes-induced glomerular hyperfiltration via efferent arteriole dilation and inhibition of tubular sodium reabsorption." American Journal of Physiology-Renal Physiology 297, no. 5 (2009): F1265—F1272. http://dx.doi.org/10.1152/ajprenal.00228.2009.

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C-peptide reduces diabetes-induced glomerular hyperfiltration in diabetic patients and experimental animal models. However, the mechanisms mediating the beneficial effect of C-peptide remain unclear. We investigated whether altered renal afferent-efferent arteriole tonus or alterations in tubular Na+ transport (TNa) in response to C-peptide administration mediate the reduction of diabetes-induced glomerular hyperfiltration. Glomerular filtration rate, filtration fraction, total and cortical renal blood flow, total kidney O2 consumption (Qo2), TNa, fractional Na+ and Li+ excretions, and tubular

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3

Schiffrin, Ernesto L. "Vascular receptors for angiotensin, vasopressin, and atrial natriuretic peptide in experimental hypertension." Canadian Journal of Physiology and Pharmacology 67, no. 9 (1989): 1118–23. http://dx.doi.org/10.1139/y89-178.

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Angiotensin II (ANG II) and vasopressin (AVP) are two powerful vasoconstrictors, and atrial natriuretic peptide (ANP) is a potent vasorelaxant. The changes in the density or affinity of binding sites for these agents that may alter target organ responsiveness in hypertension are reviewed. ANG II binding in mesenteric arteries was unaltered in one-kidney, one-clip (1-K, 1-C) and in 2-K,1-C hypertensive rats, while in deoxycorticosterone acetate (DOCA)-salt hypertensive rats ANG II binding to blood vessels was significantly increased. A role of mineralocorticoids to increase the number of vascul

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4

Fraenkel, Margaret B., G. Peter Aldred, and John G. McDougall. "Sodium Status Affects Gc-B Natriuretic Peptide Receptor mRNA Levels, but Not Gc-A Or C Receptor Mrna Levels, in the Sheep Kidney." Clinical Science 86, no. 5 (1994): 517–22. http://dx.doi.org/10.1042/cs0860517.

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1. In humans and experimental animals the natriuresis and diuresis resulting from infusion of atrial natriuretic peptide varies with the sodium status of the subject. Tissue binding studies have suggested that this may be related to changes in the renal receptors for the hormone. 2. In order to establish whether these changes are under transcriptional control, we examined the levels of mRNA for the three natriuretic peptide receptors [GC-A, GC-B and clearance (C) receptors] in renal cortex and medulla from six sodium-loaded, six sodium-depleted and four control sheep. cDNA probes specific to e

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Prickett, Timothy C. R., Helen Lunt, Julie Warwick, Helen F. Heenan, and Eric A. Espiner. "Urinary Amino-Terminal Pro–C-Type Natriuretic Peptide: A Novel Marker of Chronic Kidney Disease in Diabetes." Clinical Chemistry 65, no. 10 (2019): 1248–57. http://dx.doi.org/10.1373/clinchem.2019.306910.

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Abstract BACKGROUND Chronic renal inflammation and fibrosis are common sequelae in diabetes mellitus (DM) and are major causes of premature mortality. Although upregulation of NPPC expression occurs in response to renal inflammation in experimental animals, nothing is known of the molecular forms of C-type natriuretic peptide (CNP) products in urine of people with DM or links with renal function. METHODS ProCNP products in urine were characterized with HPLC and a range of antisera directed to specific epitopes of amino-terminal proCNP (NTproCNP). The 5-kDa intact peptide was quantified in spot

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Nikapitiya, Chamilani, S. H. S. Dananjaya, H. P. S. U. Chandrarathna, Mahanama De Zoysa, and Ilson Whang. "Octominin: A Novel Synthetic Anticandidal Peptide Derived from Defense Protein of Octopus minor." Marine Drugs 18, no. 1 (2020): 56. http://dx.doi.org/10.3390/md18010056.

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The rapid emergence of multidrug-resistant pathogens makes an urgent need for discovering novel antimicrobial agents as alternatives to conventional antibiotics. Towards this end, we designed and synthesized a synthetic peptide of 23 amino acids (AAs) (1GWLIRGAIHAGKAIHGLIHRRRH23) from a defense protein 3 cDNA sequence of Octopus minor. The sequence of the peptide, which was named Octominin, had characteristic features of known antimicrobial peptides (AMPs) such as a positive charge (+5), high hydrophobic residue ratio (43%), and 1.86 kcal/mol of Boman index. Octominin was predicted to have an

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Chaturvedi, Ashok K., A. Kavishwar, G. B. Shiva Keshava, and P. K. Shukla. "Monoclonal Immunoglobulin G1 Directed against Aspergillus fumigatus Cell Wall Glycoprotein Protects against Experimental Murine Aspergillosis." Clinical Diagnostic Laboratory Immunology 12, no. 9 (2005): 1063–68. http://dx.doi.org/10.1128/cdli.12.9.1063-1068.2005.

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ABSTRACT Most of the biological functions related to pathogenicity and virulence reside in the fungal cell wall, which, being the outermost part of the cell, mediates the host-fungus interplay. For these reasons much effort has focused on the discovery of useful inhibitors of cell wall glucan, chitin, and mannoprotein biosynthesis. In the absence of a wide-spectrum, safe, and potent antifungal agent, a new strategy for antifungal therapy is directed towards the development of monoclonal antibodies (MAbs). In the present study the MAb A9 (immunoglobulin G1 [IgG1]) was identified from hybridomas

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8

Hinkelbein, Jochen, Lennert Böhm, Stefan Braunecker, Christoph Adler, Edoardo De Robertis, and Fabrizio Cirillo. "Decreased Tissue COX5B Expression and Mitochondrial Dysfunction during Sepsis-Induced Kidney Injury in Rats." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–24. http://dx.doi.org/10.1155/2017/8498510.

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Background. Sepsis is defined as a life-threatening organ dysfunction due to a dysregulated host response to infection. Sepsis is the dominant cause of acute kidney injury (AKI), accounting for nearly 50% of episodes of acute renal failure. Signaling cascades and pathways within the kidney are largely unknown and analysis of these molecular mechanisms may enhance knowledge on pathophysiology and possible therapeutic options.Material and Methods. 26 male Wistar rats were assigned to either a sham group (control,N=6) or sepsis group (N=20; cecal ligature and puncture model, 24 and 48 hours after

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Suman, Rajesh Kumar, Ipseeta Ray Mohanty, Manjusha K. Borde, Ujwala Maheshwari, and Y. A. Deshmukh. "Development of an Experimental Model of Diabetes Co-Existing with Metabolic Syndrome in Rats." Advances in Pharmacological Sciences 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/9463476.

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Background. The incidence of metabolic syndrome co-existing with diabetes mellitus is on the rise globally.Objective. The present study was designed to develop a unique animal model that will mimic the pathological features seen in individuals with diabetes and metabolic syndrome, suitable for pharmacological screening of drugs.Materials and Methods. A combination of High-Fat Diet (HFD) and low dose of streptozotocin (STZ) at 30, 35, and 40 mg/kg was used to induce metabolic syndrome in the setting of diabetes mellitus in Wistar rats.Results. The 40 mg/kg STZ produced sustained hyperglycemia a

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Rajasekaran, Narmadha, Gomathi Duraisamy, Kalaiselvi Manokaran, and Devaki Kanakasapathi. "In Vivo Assessment of Antioxidants and Antihyperglycemic Effect of Barleria cristata leaves in Streptozotocin- Induced Diabetic Rats." International Journal of Applied Sciences and Biotechnology 2, no. 4 (2014): 437–45. http://dx.doi.org/10.3126/ijasbt.v2i4.11219.

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Objective: Many new bioactive drugs isolated from plants having hypoglycaemic effects showed anti diabetic activity equal and sometimes even more potent than known oral hypoglycaemic agents. In this present study, designed to evaluate antihyperglycermic and antioxidants effect on ethanolic leaf extracts Barleria cristata (EtBc) in streptozotocin-induced diabetic rats at dose level 400mg/kg body weight for the treatment of 45 days. Method and materials: The experimental rats were randomly divided into five groups as a control, streptozotocin induced with diabetes (45mg/kg bw) without any treatm

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Chua, Winnie, Jonathan P. Law, Victor R. Cardoso, et al. "Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: A validation study." PLOS Medicine 18, no. 2 (2021): e1003405. http://dx.doi.org/10.1371/journal.pmed.1003405.

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Background Large-scale screening for atrial fibrillation (AF) requires reliable methods to identify at-risk populations. Using an experimental semi-quantitative biomarker assay, B-type natriuretic peptide (BNP) and fibroblast growth factor 23 (FGF23) were recently identified as the most suitable biomarkers for detecting AF in combination with simple morphometric parameters (age, sex, and body mass index [BMI]). In this study, we validated the AF model using standardised, high-throughput, high-sensitivity biomarker assays. Methods and findings For this study, 1,625 consecutive patients with eit

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12

Poteryaeva, O. N., and I. F. Usynin. "Molecular mechanisms of action and physiological effects of the proinsulin C-peptide (a systematic review)." Biomeditsinskaya Khimiya 66, no. 3 (2020): 196–207. http://dx.doi.org/10.18097/pbmc20206603196.

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The C-peptide is a fragment of proinsulin, the cleavage of which forms active insulin. In recent years, new information has appeared on the physiological effects of the C-peptide, indicating its positive effect on many organs and tissues, including the kidneys, nervous system, heart, vascular endothelium and blood microcirculation. Studies on experimental models of diabetes mellitus in animals, as well as clinical trials in patients with diabetes, have shown that the C-peptide has an important regulatory effect on the early stages of functional and structural disorders caused by this disease.

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13

Ryk, Aleksandra, Aleksandra Łosiewicz, Arkadiusz Michalak, and Wojciech Fendler. "Biological Activity of c-Peptide in Microvascular Complications of Type 1 Diabetes—Time for Translational Studies or Back to the Basics?" International Journal of Molecular Sciences 21, no. 24 (2020): 9723. http://dx.doi.org/10.3390/ijms21249723.

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People with type 1 diabetes have an increased risk of developing microvascular complications, which have a negative impact on the quality of life and reduce life expectancy. Numerous studies in animals with experimental diabetes show that c-peptide supplementation exerts beneficial effects on diabetes-induced damage in peripheral nerves and kidneys. There is substantial evidence that c-peptide counteracts the detrimental changes caused by hyperglycemia at the cellular level, such as decreased activation of endothelial nitric oxide synthase and sodium potassium ATPase, and increase in formation

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14

ROBERTSON, Alexis, Gavin S. MacCOLL, Julia A. B. NASH, Mark K. BOEHM, Stephen J. PERKINS, and Pierre-Marc G. BOULOUX. "Molecular modelling and experimental studies of mutation and cell-adhesion sites in the fibronectin type III and whey acidic protein domains of human anosmin-1." Biochemical Journal 357, no. 3 (2001): 647–59. http://dx.doi.org/10.1042/bj3570647.

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Anosmin-1, the gene product of the KAL gene, is implicated in the pathogenesis of X-linked Kallmann's syndrome. Anosmin-1 protein expression is restricted to the basement membrane and interstitial matrix of tissues affected in this syndrome during development. The anosmin-1 sequence indicates an N-terminal cysteine-rich domain, a whey acidic protein (WAP) domain, four fibronectin type III (FnIII) domains and a C-terminal histidine-rich region, and shows similarity with cell-adhesion molecules, such as neural cell-adhesion molecule, TAG-1 and L1. We investigated the structural and functional si

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15

Zhao, Chengquan, Tung Nguyen, Lide Liu, Randy E. Sacco, Kim A. Brogden та Robert I. Lehrer. "Gallinacin-3, an Inducible Epithelial β-Defensin in the Chicken". Infection and Immunity 69, № 4 (2001): 2684–91. http://dx.doi.org/10.1128/iai.69.4.2684-2691.2001.

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ABSTRACT Gallinacin-3 and gallopavin-1 (GPV-1) are newly characterized, epithelial β-defensins of the chicken (Gallus gallus) and turkey (Meleagris gallopavo), respectively. In normal chickens, the expression of gallinacin-3 was especially prominent in the tongue, bursa of Fabricius, and trachea. It also occurred in other organs, including the skin, esophagus, air sacs, large intestine, and kidney. Tracheal expression of gallinacin-3 increased significantly after experimental infection of chickens with Haemophilus paragallinarum, whereas its expression in the tongue, esophagus, and bursa of Fa

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16

Berdel, Wolfgang E., Torsten Kessler, Christian Schwöppe, et al. "Targeting Tissue Factor to Tumor Vessels. Experimental Results and First-in-Man Experience." Blood 114, no. 22 (2009): 469. http://dx.doi.org/10.1182/blood.v114.22.469.469.

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Abstract Abstract 469 Activation of blood coagulation in tumor vessels with subsequent tumor infarction is an experimental strategy in cancer therapy. We have fused different targeting peptides, including GRGDSP (RGD), GNGRAHA (NGR) and 5 cyclic derivates to the C-terminus of truncated tissue factor (tTF) to preferentially target tumor vessel endothelial cell integrins such as αvβ3 or aminopeptidase (CD13). tTF fusion proteins were expressed in E. coli, purified and refolded. Molecular integrity of the fusion proteins was evaluated by SDS-PAGE, immunoblotting and mass spectrometry. Subsequentl

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17

Banti, Rafael S., Rodrigo Yokota, Danielle S. Aragão, et al. "Abstract P104: Renin Angiotensin System (RAS) Modulation in Hypertension Program by Maternal Intrauterine Malnutrition." Hypertension 66, suppl_1 (2015). http://dx.doi.org/10.1161/hyp.66.suppl_1.p104.

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Intrauterine malnutrition (IM) during the early stages of development can alter the function of organs and tissues and can predict a lifetime of increased risk for adverse health outcomes, such as diabetes and hypertension. The kidney plays a key role in the development of hypertension programmed by IM, with the participation of the RAS. Our objectives were to study ACE activity and angiotensin peptides levels in tissues. Pregnants Wistar rats were separated into two groups: control group (C), fed ad libitum, and malnourished group (D) submitted to food restriction (diet 50% of the amount of f

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Freitas, Camila G., Stella M. F. Lima, Mirna S. Freire, et al. "An Immunomodulatory Peptide Confers Protection in an Experimental Candidemia Murine Model." Antimicrobial Agents and Chemotherapy 61, no. 8 (2017). http://dx.doi.org/10.1128/aac.02518-16.

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ABSTRACT Fungal Candida species are commensals present in the mammalian skin and mucous membranes. Candida spp. are capable of breaching the epithelial barrier of immunocompromised patients with neutrophil and cell-mediated immune dysfunctions and can also disseminate to multiple organs through the bloodstream. Here we examined the action of innate defense regulator 1018 (IDR-1018), a 12-amino-acid-residue peptide derived from bovine bactenecin (Bac2A): IDR-1018 showed weak antifungal and antibiofilm activity against a Candida albicans laboratory strain (ATCC 10231) and a clinical isolate (CI)

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19

Thisted, Louise, Mette V. Østergaard, Annemarie A. Pedersen, et al. "Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy." Scientific Reports 10, no. 1 (2020). http://dx.doi.org/10.1038/s41598-020-73046-8.

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Abstract Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models recapitulating the human disease. We hypothesized that experimental diabetes in rats combined with a cardiac or renal stressor, would mimic diabetic cardiomyopathy and nephropathy, respectively. Diabetes was surgically induced in male Sprague Dawley rats by 90% pancreatectomy (Px). Isoprenaline (Iso, 1 mg/kg, sc., 10 days) was administered 5 weeks after Px with the aim of i

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Tsujita, Maki, Nobukatsu Akita, M. Anwar Hossain, et al. "Abstract 231: ABCG1 Null and SR-BI Null Mice Reduced Plasma HDL Uptake by the Liver and Small Intestine." Arteriosclerosis, Thrombosis, and Vascular Biology 34, suppl_1 (2014). http://dx.doi.org/10.1161/atvb.34.suppl_1.231.

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Aim: To reveal cholesterol transport via non-liver excretion pathway of plasma HDL-cholesterol, we focused on small intestinal and kidney in hyper- and hypo-lipoproteinemia model mice. Method: Mouse plasma was collected within EDTA coated tubes. Plasma lipoprotein profiles were measured by size exclusion HPLC and plasma preβHDL level was detected by immno-blotting of 2D PAGE by anti-mouse apoA-I peptide polyclonal antibody. Mouse HDL was co-incubated with 3H-cholesteryl oleyl ether (CEt) presence of CETP containing human plasma proteins for 48 hrs. The (100μL) of 3H-CEt-HDL was injected trough

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Zhang, Zhiquan, Qing Ma, and Mihai V. Podgoreanu. "Abstract 13522: Annexin-A1 Bioactive Peptide Ameliorates Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) in Rats by Upregulating the Sirtuin6/FoxO3 Pathway." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.13522.

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Introduction: Acute kidney injury (AKI) is a prevalent and prognostically important complication of cardiac surgery. The complex multifactorial pathogenesis and lack of appropriate animal models to recapitulate the clinical insults leading to CSA-AKI have been implicated in the failure of multiple pharmacologic renoprotective strategies. We have reported anti-inflammatory and renoprotective effects of a novel Annexin-A1 (ANXA1) tripeptide (Ac-QAW) in a rodent model of experimental cardiac surgery. Here, we tested the hypothesis that Ac-QAW attenuates CSA-AKI by upregulating Sirtuin6 and Forkhe

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22

Singh, Amita, Raj Kumar, S. K. Kannaujia, Manikrishna Manikrishna, and N. P. Singh. "IMMUNOHISTOCHEMICAL STUDIES OF BLOOD BRAIN BARRIER AFTER ADMINISTRATION OF ABHRAK BHASM IN WISTAR RATS." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, April 1, 2021, 13–19. http://dx.doi.org/10.36106/ijsr/6505925.

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Abhrak bhasma (AB) is a type of bhasma prepared from repeated incineration of mineral mica with decoctions of about 72 herbs. The particle size of Abhrak bhasm has been shown to be in the range of 29-88 nanometers and Fe, Ca, Si, Mg and K are found to be as major constituent. Many drugs developed to treat Central Nervous System (CNS) disorders are unable to reach the brain parenchyma in therapeutically relevant concentrations. The blood brain barrier protects brain parenchyma from the uctuation of plasma composition, from pathogenic agents and maintains homeostasis of the brain parenchyma by

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23

Ichiki, Tomoko, Gail J. Harty, Brenda K. Huntley, S. Jeson Sangaralingham, Gerald E. Harders, and John C. Burnett. "Abstract 11554: Chronic Cenderitide Administration Improves Cardiorenal Function and Remodeling in Experimental Heart Failure." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.11554.

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Introduction: Heart failure (HF) is a major health burden in which renal impairment worsens prognosis. Targeting the vicious cycle between heart and kidney may be a more optimal therapeutic strategy for HF. The cardiac natriuretic peptides have cardiorenal protective effects through their receptor GC-A and GC-B. We sought to determine the actions of chronic administration of the dual GC-A/GC-B agonist cenderitide (CD-NP) upon cardiorenal function in experimental HF. Hypothesis: Chronic cenderitide therapy will improve cardiorenal function in HF. Methods: Experimental canine HF was induced by r

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