Relevant bibliographies by topics / Experimental tumor

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Experimental tumor'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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Journal articles on the topic "Experimental tumor"

1

Okajima, Eigoro, and Seiichiro Ozono. "EXPERIMENTAL BLADDER TUMOR." Japanese Journal of Urology 82, no. 5 (1991): 705–15. http://dx.doi.org/10.5980/jpnjurol1989.82.705.

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Grigore, Ana Camelia, Camelia Busila, Ioana Bianca Chesaru, Alina Calin, and Liliana Lacramioara Pavel. "Biological Features of Tumors Results of Experimental Studies." Revista de Chimie 68, no. 3 (April 15, 2017): 594–98. http://dx.doi.org/10.37358/rc.17.3.5508.

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Tumor anaplasia can be of varying degrees, being especially marked in fast-growing malignant tumors. Blastomatose tissue is characterized by morphological, chemical, physico-chemical and energetic anaplasia. Structural changes of the tissue specific to blastomatose growth often provide the opportunity to differentiate this tissue from a normal or any other growing tissue. Out of various factors that may influence the external environment of tumors, we should mention food, profession, living and working conditions. Tumors and especially malignant tumors are accompanied by changes in the entire body. These are not just a consequence of the blastomatose growth but also play a role in its subsequent development. Experimental tumors are one of the methods of studying the issue of blastomatose growth. The tumor transplantation method is widespread and extensively applied in laboratory practice. It uses standard strains of tumors (rats, mice, etc.). The simplicity of the tumor transplantation method, which consists of the inoculation under the skin of animals of tumor fragments using a trocar or of the injection of a tumor emulsion under aseptic conditions, enables researchers to maintain the purity of the strain for a long time. Various views have been formulated at different times on the origin of tumor growth in accordance with the level of knowledge on this issue.
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Sikora, K. "Brain Tumor Biology - Progress in Experimental Tumor Research." British Journal of Cancer 51, no. 3 (March 1985): 447. http://dx.doi.org/10.1038/bjc.1985.64.

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Ware, Jerry, Masahiko Zuka, Shaskank Jain, Susan Russell, Judith Dent, Jane Forsyth, Brigid Maruszak, and Brunhilde Felding-Habermann. "Platelet Glycoprotein Ibα Supports Primary Tumor Growth and Experimental Metastasis." Blood 108, no. 11 (November 16, 2006): 1463. http://dx.doi.org/10.1182/blood.v108.11.1463.1463.

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Abstract Successful tumor formation and metastatic spread depend on the ability of tumor cells to interact with their host microenvironment. Studies from our groups and others indicate that platelets contribute to tumor host interactions through adhesive and stimulatory functions that may promote tumor growth and dissemination. Here we show that platelet receptor GPIbα plays a critical role in the ability of platelets to support primary tumor development and hematogenous metastasis. We previously developed knockout mice lacking platelet GP Ibα (GPIbαNull, a model of the human Bernard-Soulier syndrome) and mice missing GPIbα, but expressing a fusion protein of cytoplasmic GP Ibα and the extracytoplasmic domain of the interleukin-4 receptor (Ibα/IL-4R). Expression of the Ibα/IL-4R ameliorates macrothrombocytopenia, a characteristic of the Bernard-Soulier syndrome. However, both models result in a severe hemorrhagic state owing to the absence of GPIbα. Congenic mouse strains of both GP Ibα models were generated by 10-generation backcrosses with wild-type (WT) C57BL/6J mice to study the tumorgenic and metastatic activity of syngeneic tumor cells. To analyze primary tumor growth, Lewis lung carcinoma cells (D121) were injected intradermally in the dorsal flank of the hind limb (105 cells/injection) and tumor development analyzed in its initial and advanced stages. Seventeen days after injection, tumors in GPIbαNull and Ibα/IL-4R mice were several-fold smaller than those in WT C57BL/6J mice. Histological examination of early and end-stage tumors revealed three major differences: a severe and immediate onset of tumor necrosis, a lack of new blood vessels large enough to connect to the circulation, and a significant reduction in tumor-associated macrophages. While the proliferation rate of tumor cells in non-necrotic areas of the tumors was unaffected by the lack of GPIbα, the percentage of necrosis in these tumors was 6-fold increased in GPIbαNull mice. Each necrotic area showed increased hemorrhage in the absence of GPIbα. The overall density of microvessels in early primary tumors appeared unchanged, but the number of larger vessels associated with tumors was reduced ~2-fold and the density of tumor-associated macrophages was reduced ~6-fold compared to tumors developing in WT mice. To analyze a contribution of platelet GPIbα to hematogenous tumor metastasis, another syngeneic tumor cell model was used and B16F10.1 melanoma cells were injected into the tail vein (105 cells/mouse) of GPIbαNull, Ibα/IL-4R, or WT mice, to determine the ability of tumor cells to colonize the lungs 14 days later. In the absence of functional GPIbα, the number of metastatic foci at the surface of the lungs was significantly reduced (15-fold, p = 0.0002). These results indicate that successful target organ colonization by tumor cells from the blood stream is severely affected by the lack of extracytoplasmic GPIbα in Ibα/IL-4R animals, and not necessarily by the reduced number of platelets in GPIbαNull animals. The results demonstrate a significant involvement of platelet GP Ibα in primary tumor growth by affecting tumor angiogenesis and the recruitment of tumor-associated macrophages while providing evidence GPIbα directly contributes to target organ colonization by circulating tumor cells. These studies identify platelet GP Ibα as a potential new target for anti cancer therapy.
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MuellerKlieser, W. "Tumor biology and experimental therapeutics." Critical Reviews in Oncology/Hematology 36, no. 2-3 (November 2000): 123–39. http://dx.doi.org/10.1016/s1040-8428(00)00082-2.

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Colmbo, M. P. "Gene therapy of experimental tumor." Melanoma Research 3, no. 1 (March 1993): 16. http://dx.doi.org/10.1097/00008390-199303000-00047.

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Hau, Dou-Mong, I.-Hsin Lin, Jaung-Geng Lin, Yung-Hsich Chang, and Ching-Ha Lin. "Therapeutic Effects of Moxibustion on Experimental Tumor." American Journal of Chinese Medicine 27, no. 02 (January 1999): 157–66. http://dx.doi.org/10.1142/s0192415x99000203.

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This work investigated the therapeutic effects of the improved form of moxibustion (MT) on experimental tumor. Sarcoma 180 cells (1 × 107) were transplanted into the subcutaneous tissue in the breast area of female ICR mice. Mice bearing a tumor were divided into one control and four experimental groups. The experimental groups were treated with MT for 1, 2, 3 and 4 times (abbreviated as MT1, MT2, MT3, MT4, respectively). This study showed that the experimental group treated with MT3 displayed the optimal therapeutic response. The longest mean survival time (87.8 days) within 120 days after treatment of MT3 significantly differed from the control group (60.2 days). In addition, uptake of 86Rb-radioactive tracer significantly decreased in tumors treated with MT3. The improved form of moxibustion used in this study is a reliable model of localized hyperthermia in tumor therapy.
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Wu, Q., B. Tyler, L. Sukay, L. Rhines, F. Dimeco, R. E. Clatterbuck, M. Guarnieri, and B. S. Carson. "Experimental Rodent Models of Brainstem Tumors." Veterinary Pathology 39, no. 3 (May 2002): 293–99. http://dx.doi.org/10.1354/vp.39-3-293.

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Despite recent advances in surgical technology, resection is not an option for many brainstem tumors. Experimental models have played essential roles in examining new approaches to therapy. The objective of the present study was to generate models by determining coordinates for safe inoculation into the brainstem of mice and rats, and to establish whether the implantation of heterotopic cells would create reproducible survival curves. Morbidity and survival studies were used to map stereotactic coordinates allowing successful inoculation of tumor cells. Survival studies were used to investigate the time course of tumor growth. Tumor location was examined by light microscopy and magnetic resonance imaging. Mice survived injections of 2 μL of saline at interaural, lateral, and depth coordinates of −2.5, 1.0, and 3.5 mm and −1.5, 1.0, and 3.5 mm. Rats survived injections at interaural, lateral, and depth coordinates of −2.0, 2.0, and 7.0 mm and −3.0, 0, and 7.0 mm. Median survival of mice challenged with 5 × 105 EMT6 and 104 B16 tumor cells was 11 and 10 days, respectively. Median survival for rats challenged with 104 9L and F98 cells was 14 and 13 days, respectively. The present study demonstrates a feasible approach to preparing models of brainstem tumors. Limitations of these models are discussed.
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Inamura, Takanori, and Keith L. Black. "Bradykinin Selectively Opens Blood-Tumor Barrier in Experimental Brain Tumors." Journal of Cerebral Blood Flow & Metabolism 14, no. 5 (September 1994): 862–70. http://dx.doi.org/10.1038/jcbfm.1994.108.

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Bradykinin, infused in low doses (10 μg/kg/min) through the carotid artery ipsilateral to RG2 glioma in rats, significantly increased the permeability in tumor capillaries to six different tracers of varying molecular weights compared with intracarotid infusion of saline alone. Permeability in normal brain capillaries was not significantly increased by intracarotid bradykinin infusion. Tracers used to examined permeability included radiolabeled α-aminoisobutyric acid (AIB; MW 103), sucrose (MW 342.3), inulin (MW 5000), and dextran (MW 70,000), horseradish peroxidase (HRP) and Evans blue (EB). Permeability was expressed as the unidirectional transfer constant Ki (μl/g/min). The permeabilities ( Ki) of tumors in the bradykinin group versus the control saline group for AIB, sucrose, inulin, and dextran were 25.91 ± 6.78 vs. 13.95 ± 4.29 (p < 0.01), 17.90 ± 2.65 vs. 10.75 ± 4.55 (p < 0.01), 23.92 ± 6.99 vs. 6.20 ± 4.37 (p < 0.01), and 17.84 ± 1.00 vs. 1.47 ± 1.24 (p < 0.001), respectively (mean ± SD). Permeability of RG2 gliomas to high molecular weight dextran (70,000) was 12-fold higher in the bradykinin group than in the saline infusion group. Intracarotid infusion of bradykinin did not significantly increase the blood volume in tumor or brain tissue despite its known vasodilative effect. The permeability of normal brain capillaries was unaffected by intracarotid bradykinin infusion. The increased permeability was reversed 20 min after stopping the intracarotid infusion. Electron microscopic and gross qualitative analysis was performed using HRP and EB. Intracarotid bradykinin infusion increased HRP and EB within tumor tissue but not normal tissue. We believe that intracarotid infusion of bradykinin will be a useful technique for selective delivery of antitumor compounds to brain tumors.
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Wong, Vernon G., and Ralph S. Viola. "Effect of rH Tumor Necrosis Factor on Experimental Intraocular Tumors." Cornea 10, no. 2 (March 1991): 131–35. http://dx.doi.org/10.1097/00003226-199103000-00008.

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Dissertations / Theses on the topic "Experimental tumor"

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Tore, Aas Alf. "Experimental brain tumor metabolism and therapy." Lund, Sweden : Dept. of Neurosurgey, University Hospital, 1994. http://books.google.com/books?id=4XlrAAAAMAAJ.

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Zarur, Jamil Martins. "Modelo experimental de quimioembolizaÃÃo hepÃtica." Universidade Federal do CearÃ, 2004. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=166.

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CoordenaÃÃo de AperfeiÃoamento de NÃvel Superior
OBJETIVO: Estabelecer um modelo de tumor no fÃgado de ratos para estudo do comportamento tumoral e avaliar o uso da quimiembolizaÃÃo transarterial. MÃTODOS: Utilizou-se oitenta e oito ratos Wistar, fÃmeas, adultos, pesando entre 175- 284 g . Realizado incisÃo abdominal de 3 cm e implantou-se o carcinossarcoma de Walker 256 no lÃbulo esquerdo do fÃgado. Dividiu-se em trÃs grupos que receberam respectivamente 100x 103 , 200x 103 e 300x 103 cÃlulas tumorais, avaliado a pega do tumor e a sobrevida. Em outro grupo de experimento com 39 animais inoculados com tumor de Walker foi avaliado a sobrevida dos animais apÃs infusÃo do 5-Flourouracil (5-FU) por via intra-peritoneal e intra-arterial. RESULTADOS: O implante do carcinossarcoma de Walker no fÃgado de ratos apresentou desenvolvimento de 100 %, teve um crescimento rÃpido e desenvolvimento de metÃstases tardiamente, levando os animais ao Ãbito entre o sÃtimo e dÃcimo quinto dia. A quimiembolizaÃÃo transarterial à possÃvel de ser realizada experimentalmente. O uso do 5-FU aumentou a sobrevida em comparaÃÃo ao grupo controle. CONCLUSÃO: O modelo de implante do tumor de Walker no fÃgado de ratos à eficiente, de fÃcil reprodutibilidade, e sobrevida mÃdia de 9,96Â0.3 dias. A quimioterapia transarterial hepÃtica pode ser realizada experimentalmente para avaliar diversas drogas.
PURPOSE: An animal model to study the behaviour of liver tumor in rat and its response after use of transarterial chemoembolization. METHODS: We use 88 Wistar rats, all of them were females, adult, weight 175-284 g. Abdominal incison of three cm and implanted the Walker carcinossarcoma 256 at left lobule of the liver. The animals were divided into three grups, that received 100x103 , 200x103, and 300x103 cells. Followed up the animas to avaliate life standing and tumoral development. In another experiment was used 39 animals which already had Walker 256 tumor and we study the survival of the animals after treatment with 5-FU IP or 5-FU IA. RESULTS: The orevall tumor development rate were 100%. Tumor growth was fast, and devolopment metastases on old fase. The animals dead between 7Â and 15Â day. Its possible to do chemoembolization experimentaly, after the use of 5-FU the rate survival increased. CONCLUSION: The model with Walker 256 tumor developed here is easy to repoduce, efficient, with high tumor development rate observed, the life standing is about 9,96 Â 0,3 days. The chemoembolization experiment allows to assess several drugs.
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Sheikholvaezin, Ali. "Recombinant antibodies and tumor targeting." Doctoral thesis, Umeå : Univ, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-875.

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Swarup, Arvind. "Experimental characterisation of the dielectric properties of tumor tissues." Thesis, University of Ottawa (Canada), 1987. http://hdl.handle.net/10393/5162.

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Morano, Josà AntÃnio Carlos Otaviano David. "AvaliaÃÃo dos efeitos da hipertermoterapia por ultrasom associada a agentes antiangiogÃnicos no tratamento do tumor experimental de walker." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4685.

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CoordenaÃÃo de AperfeiÃoamento de NÃvel Superior
Os mÃtodos tradicionais de tratamento do cÃncer, como a quimioterapia e a radioterapia, embora sejam eficazes em vÃrios tipos de tumores, encontram freqÃentemente populaÃÃes de cÃlulas neoplÃsicas resistentes, alÃm de apresentarem uma baixa margem de seguranÃa para os pacientes. A utilizaÃÃo da hipertermia associada à quimioterapia e/ou radioterapia jà se encontra fartamente relatada como vantajosa na literatura especializada, principalmente em pacientes portadores de cÃncer em estÃdio avanÃado, submetidos previamente aos mÃtodos clÃssicos de tratamento. A aplicaÃÃo de calor nos tecidos atravÃs de ultrassom contÃnuo torna mais Ãgil Ãste procedimento e com eficÃcia comprovada. O uso dos antiangiogÃnicos tambÃm vem sendo relatado como eficaz na literatura especializada e atualmente, a lista destas substÃncias vem aumentando consideravelmente. O estudo da aÃÃo da hipertermia associada a alguns agentes antiangiogÃnicos tem sido sugerida uma vez que os vasos tumorais ao encontrarem-se dilatados, nÃo promoverÃo a diminuiÃÃo da temperatura no tecido tumoral e, consequentemente, os efeitos desta associaÃÃo serÃo mais intensos do que no tecido normal devendo contribuir para a morte celular. Objetiva-se neste trabalho, avaliar o efeito antitumoral e antiangiogÃnico da hipertermia induzida por US isolada e combinada com etoricoxibe e pegaptanibe,no carcinossarcoma de Walker 256 implantado na tela subcutÃnea do dorso de ratos por meio de utilizaÃÃo do modelo experimental de hipertermoterapia por US assim como o estudo dos efeitos da hipertermia por US isolada e em combinaÃÃo com etoricoxibe e pegaptanibe,na angiogÃnese tumoral.O mÃtodo utilizado para o estudo teve inÃcio com o implante de cÃlulas de tumor de Walker 256 no dorso de ratos Wistar machos. Os animais foram tratados com hipertermia aplicada atravÃs de aparelho de ultrassom, mantida a nÃvel de 45o C durante cinco minutos no terceiro dia apÃs a inoculaÃÃo e tambÃm tratados com etoricoxibe e pegaptanibe por via oral e intraperitoneal respectivamente a partir do dia da inoculaÃÃo. Cada grupo de animais foi submetido a medidas do crescimento tumoral durante o perÃodo de 30 dias, assim como tambÃm à avaliaÃÃo da microdensidade vascular atravÃs de estudo mesoscÃpico fotogrÃfico, validado pelo estudo microscÃpico. A aplicaÃÃo do calor atravÃs de aparelho de ultrasom demonstrou eficiÃncia e agilidade A hipertermia, o etoricoxibe e o pegaptanibe, apresentaram capacidade antiangiogÃnica, expressada tanto pela curva de sobrevida, como pela avaliaÃÃo da microdensidade vascular. Particularmente, a hipertermia isoladamente apresentou um efeito antiangiogÃnico significativo tanto na curva de crescimento tumoral como na diminuiÃÃo da densidade microvascular. A associaÃÃo da hipertermia com o pegaptanibe, demonstrou uma eficiÃncia na diminuiÃÃo da densidade microvascular significativamente maior do que os demais grupos. O modelo de aplicaÃÃo de hipertermia gerada por um aparelho de ultrassom na modalidade contÃnua foi satisfatÃria, demonstrando ter sido efetiva tanto na diminuiÃÃo do crescimento tumoral, como na diminuiÃÃo da densidade microvascular.
The traditional methods of cancer treatment, like the chemotherapy and radiotherapy, even though they are effective in many types of tumours, they find frequently resistant neoplasic cellsâ population, beyond presenting a low security margin to the patients. The hyperthermia use associated to the chemotherapy and radiotherapy are plenty mentioned as profitable in the specialist literature, especially in patients with cancer in advanced stage, submitted previously to the classic methods of the treatment. The tissuesâ heat insertion through the continuous ultrasound becomes the procedure faster and with proved efficacy. The antiangiogenic use also is being related like effective in the specialist literature and, at this moment, the substancesâ list has grown vastly. The study of the hyperthermia action associated to antiangiogenic agents has been suggested, once the tumour vessels are dilated, would not promote the temperature reduction in the tumour vessels and, therefore, the effects of this association would be more intense than in the normal tissue, what might contribute to the death cell. The study objective is to evaluate the antitumor and antiangiogenic effect of the hyperthermia induced by isolated ultrasound and combined with etoricoxibe and pegaptanibe in the 256 Walker carcinossarcoma implanted in the subcutaneous back screen of mouse by using the hyperthermia experimental model by ultrasound, like the hyperthermia effects study by isolated ultrasound and linked with etoricoxibe and pegaptanibe, in the tumour angiogenesis. The method used describes the insertion of 256 Walker Tumour cells in the back of male Wistar mouse. The animals were treated with hyperthermia applied through the ultrasound equipment, kept to a 45Â C level during five minutes in the third day after the inoculation and also treated with etoricoxibe and pegaptanibe by oral and intraperitoneal respectively since the inoculation day. Each animal group was submitted to a tumour growth measurement during a period of 30 days, as well as also a vascular microdensity evaluation through a photographic mesoscopic study, validated by the microscopic study. The heat application through the ultrasound equipment demonstrated efficiency and agility. The hyperthermia, the etoricoxibe and the pegaptanibe showed antiangiogenic capacity, expressed by the over life curve, and also by the vascular microdensity evaluation. Particularly, the isolated hyperthermia showed a significative antiangiogenic effect in the tumour growth curve and also in the decreasing of the micro vascular density. The association between the hyperthermia and the pegaptanibe demonstrated a greater efficiency in the reducing of the micro vascular density than the other groups. The hyperthermia application model generated by the ultrasound equipment in the continuous modality was satisfactory, demonstrating by being effective as much in the reducing of the tumour growth as in the decreasing of the micro vascular density.
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Hogerlinden, Max van. "NF-kB in epidermal signal transduction and tumor development /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-383-x/.

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Andreatta-Van, Leyen Sheila. "Experimental approaches for enhancing wound healing and inhibiting tumor growth." Case Western Reserve University School of Graduate Studies / OhioLINK, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=case1061557930.

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Oliveira, Paulo Ferdinando de Melo. "AvaliaÃÃo da hipertermoterapia associada ao Paclitaxel, 5-Fluorouracil e 5-Fluorouracil mais Ãcido FolÃnico no Tumor de Walker 256 implantado em estÃmagos de rato." Universidade Federal do CearÃ, 2003. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=393.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico
IntroduÃÃo: As drogas quimioterÃpicas convencionais nÃo tÃm obtido sucesso no tratamento do cÃncer gÃstrico. O paclitaxel (TaxolÂ) mostrou ser efetivo no tratamento dos cÃnceres de ovÃrio, mama e pulmÃo. O 5-fluorouracil (5-FU) tem apresentado resultados promissores no tratamento do cÃncer de cÃlon. O Ãcido folÃnico (LeucovorinÂ) potencializa a citotoxicidade do 5-fluorouracil. Estudos desen-volvidos no JapÃo, Estados Unidos e Europa vÃm sugerindo o uso de quimioterapia associada à hiper-termia no controle da doenÃa localmente avanÃada. Objetivos: Avaliar a influÃncia do paclitaxel, 5-fluorouracil e 5-fluorouracil mais Ãcido folÃnico, isolados e associados à hipertermia, na sobrevida de ratos com tumor de Walker 256 implantados no estÃmago, e observar o comportamento do tumor de Walker 256 original implantado em estÃmagos de rato sem tratamento e submetidos aos tratamentos quimioterÃpicos propostos, associados à hipertermia. MÃtodos: Implantou-se o tumor de Walker 256 na mucosa gÃstrica de rato no 3o, 7o, e 10o dias de inoculaÃÃo do tumor. Os animais foram tratados com paclitaxel, 5-fluorouracil e 5-fluorouracil mais Ãcido folÃnico, isolados e associados à hipertermia. Foram administrados paclitaxel na dose de 25 mg/m2, 5-fluorouracil na dose de 130 mg/m2 e Ãcido folÃnico na dose de 7 mg/m2. A Hipertermia de Corpo Inteiro foi iniciada 2 horas apÃs a administraÃÃo dos quimioterÃpicos, tendo duraÃÃo de 1 hora. Resultados: Os animais inoculados com tumor apresentaram uma sobrevida de 13,25  0,53. Os animais tratados com Paclitaxel isolado apresentaram sobrevida de 28,61  0,82; 20,92  1,77 e 20,07  0,60 no 3o, 7o e 10o dias, respectivamente, e aqueles trata-dos com Paclitaxel + hipertermia apresentaram sobrevida de 19,17  1,20; 22,54  1,47 e 17,92  1,06 nos mesmos perÃodos. Os animais tratados com 5-fluorouracil isolado apresentaram sobrevida de 16,16  0,52; 15,57  0,57 e 17,94  0,46 no 3o, 7o e 10o dias, respectivamente, e aqueles tratados com 5-fluorouracil + hipertermia apresentaram sobrevida de 14,45  0,36; 16,36  0,81 e 18,37  1,86 nos mesmos perÃodos. Os animais tratados com 5-fluorouracil + Ãcido folÃnico apresentaram sobrevida de 14,89  0,71; 16,56  0,91 e 16,11  0,67 no 3o, 7o e 10o dias, respectivamente, e aqueles tratados com 5-fluorouracil + Ãcido folÃnico + hipertermia apresentaram sobrevida de 17,60  1,22; Â15,42  0,31 e 15,45  0,39 nos mesmos perÃodos. ConclusÃes: O tumor experimental de Walker 256 à um tumor de pequenas cÃlulas. A hipertermia associada à quimioterapia, com paclitaxel, 5-fluorouracil, 5-fluorouracil mais Ãcido folÃnico como tratamento do tumor de Walker experimental implantado nos estÃmagos de rato Wistar, nÃo melhorou a sobrevida.
Introduction: The conventional chemotherapy drugs have not obtained success on the treatment of gastric cancer. The paclitaxel (TaxolÂ) showed to be effective on treating lung, breast and ovarian cancer. The 5-fluorouracil (5-FU) has shown promising results on the treatment of colon cancer. The folinic acid (LeucovorinÂ) reinforces the 5-FU cytotoxicity. Studies developed in Japan, United States and Europe suggest the use of chemotherapy associated with hyperthermia on the control of locally advanced disease. Objectives: Evaluate the influence of paclitaxel, 5-fluorouracil and 5-fluorouracil plus folinic acid, isolated and associated with hyperthermia, on the survival of rats with Walker 256 tumor implanted on their stomach, and observe the behavior of the original Walker 256 tumor implanted in the stomach of rats with no treatment and with the proposed chemotherapy treatments associated with hyperthermia. Methods: The Walker 256 tu-mor was implanted on the mucous layer of the rat stomach on the 3rd, 7th and 10th day after inoculation. The animals were treated with paclitaxel, 5-fluorouracil and 5-fluorourcil plus folinic acid isolated and associated with hyperthermia. Paclitaxel 25 mg/m2, 5-fluorouracil 130 mg/m2 and folinic acid 7 mg/m2 were used. The Whole-Body Hyperthermia was initiated 2 hours after the administration of the chemotherapic drugs, with 1 hour of duration. Results: The animals in-oculated with tumor showed a survival of 13.25 Â 0.53. The animals treated with Paclitaxel isolated showed a survival of 28.61 Â 0.82; 20.92 Â 1.77 and 20.07 Â 0.60 in the 3rd, 7th and 10th days, respectively, and those treated with Paclitaxel + hyperthermia showed a survival of 19.17 Â 1.20; 22.54 Â 1.47 and 17.92 Â 1.06 in the same periods. The animals treated with 5-fluorouracil isolated showed a survival of 16.16 Â 0.52; 15.57 Â 0.57 and 17.94 Â 0.46 in the 3rd, 7th and 10th days, respectively, and those treated with 5-fluorouracil + hyperthermia showed a survival of 14.45 Â 0.36; 16.36 Â 0.81 and 18.37 Â 1.86 in the same periods. The animals treated with 5-fluorouracil + folinic acid showed a survival of 14.89 Â 0.71; 16.56 Â 0.91 and 16.11 Â 0.67 in the 3rd, 7th and 10th days, respectively, and those treated with 5-fluorouracil + folinic acid + hyperthermia showed a survival of 17.60 Â 1.22; 15.42 Â 0.31 and 15.45 Â 0.39 in the same periods. Conclusions: The Walker 256 is a small cell tumor. The hyperthermia associated with chemotherapy using pacli-taxel, 5-fluorouracil and 5-fluorouracil plus folinic acid as treatment of Walker experimental tu-mor implanted in Wistar rat stomachs do not improved the survival.
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Erlandsson, Ann. "Interaction studies of idiotypic and antiidiotypic antibodies at experimental tumor targeting /." Umeå : Klinisk mikrobiologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-583.

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Pedro, Renato Nardi. "Uso da nanopartícula de ouro ligada a moléculas de fator alfa de necrose tumoral como adjuvante da termoablação por radiofrequência de tumores renais = modelo animal experimental." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310676.

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Orientadores: Marcelo Lopes de Lima, Nelson Rodrigues Netto Junior
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: O tratamento definitivo das massas renais malignas é primordialmente cirúrgico, sendo a nefrectomia radical eleita por muitos anos a cirurgia padrão para o tratamento do câncer renal localizado. Entretanto, com o envelhecimento populacional, maiores são as preocupações em se manter a capacidade funcional dos órgãos e sistemas do corpo humano. Portanto, a necessidade de se preservar tecido renal sadio durante o tratamento do câncer renal localizado, com auxílio de cirurgias parciais poupadoras de néfrons, se tornou imperativa. O tratamento de lesões renais sólidas pequenas passou a ter diferentes formas de abordagem, que variam desde técnicas de termoablação percutânea ou laparoscópica, nefrectomia parcial laparoscópica e aberta à até tradicional nefrectomia radical aberta. O uso de modalidades de tratamento cirúrgico com mínimo grau de agressão passou a ganhar atenção, devido à rápida recuperação do paciente, ao menor risco de complicações cirúrgicas e aos bons resultados oncológicos. Ablação por radiofreqüência (ARF) tem se mostrado um meio eficiente no tratamento de tumores renais pequenos e exofiticos. Atualmente, sua indicação é restrita a lesões de até 4 cm. O presente estudo foi montado para avaliar o uso conjunto da nanopartícula de ouro e fator alfa de necrose tumoral (TNF alfa) à ARF no tratamento de um modelo experimental de tumor renal. Materiais e Métodos: Trinta e sete coelhos brancos da raça New Zealand tiveram implantados em seus rins, através de uma laparotomia, um fragmento de 1 mm3 de tumor VX-2. Após 14 dias do implante, quando seus rins haviam desenvolvido uma lesão tumoral sólida menor que 1 cm, os animais foram divididos em 3 grupos de 10 e 1 grupo de 7 integrantes (sham) de acordo com o tratamento selecionado para o tumor renal focal: 1) Nanopartícula com TNF alfa; 2) Ablação por radiofreqüência; 3) Nanopartícula com TNF alfa seguido de Ablação por radiofreqüência; 4) Grupo sham. Todos os animais foram submetidos a mesma cronologia de tratamento, composta por 2 laparotomias e eutanásia. Os grupos tratados com as nanopartículas de ouro com fator alfa de necrose tumoral isolada ou complementarmente, as receberam 4 horas antes do procedimento cirúrgico na dose de 200 µm/Kg. A análise de resultados foi realizada com medidas macroscópicas e microscópicas do volume da área de ablação ou tumoral, segundo a fórmula do volume de uma elipsóide. Avaliação estatística foi realizada com Teste T Student, sendo considerado significante p<0.05. Resultados: O grupo que recebeu a nanopartícula com fator alfa de necrose tumoral e depois foi submetido à ARF apresentou maior zona de morte celular completa quando comparado ao grupo tratado somente com ablação por radiofreqüência (0.30 ± 0.07 vs 0.23 ± 0.03 mL, P=.03). A zona de transição foi menor no grupo que recebeu a nanopartícula com fator alfa de necrose tumoral e ablação por radiofreqüência quando comparada ao grupo tratado somente com ablação por radiofreqüência (0.08 ± 0.02 vs 0.13 ± 0.05 mL, P =.01). Conclusão: O presente estudo demonstrou que o uso da nanopartícula de ouro com TNF alfa sensibiliza o insulto térmico sofrido por tumores sólidos decorrentes da ablação por radiofreqüência
Abstract: Radical nephrectomy has long been considered as gold standard treatment for localized renal tumors. However due to an increase in life expectation, organ sparing surgeries have emerged with the purpose of preserving as much healthy tissue as possible. Therefore, nephron sparing surgeries have become another valid option for localized renal tumors. There are different modalities of nephron sparing procedures, including open partial nephrectomy, laparoscopic nephrectomy and termoablative procedures. The later is associated with less morbidity and fast patient recovery. Radiofrequency ablation (RFA) is a well-known termoablative procedure and it has been most effective when the tumors are small, exophytic, and away from vital structures. The present study was designed to analyze the adjuvant use of gold nanoparticle with tumor necrosis factor alpha prior to radiofrequency ablation in a translational model of localized renal tumor. Material and Methods: A total of 37 New Zealand White rabbits had VX-2 tumors implanted into their kidneys; they were allowed to grow for 14 days, when a tumor mass of less than 1 cm could be detected. The animals were then split into 3 treatment groups of 10 rabbits each and a sham group of 7 rabbits as follows: (1) Tumor necrosis factor alpha plus nanoparticle, (2) Radiofrequency ablation, (3) Tumor necrosis factor alpha nanoparticle (200 µm/Kg) followed 4 hours later by radiofrequency ablation. All groups were subjected to the same milestones of the experiment which was comprised of 2 laparotomies and sacrification. Gross and microscopic measurements of the ablation size as well as histological analysis using hematoxylin and eosin staining were performed to determine the effect of TNF alpha nanoparticle on the ablation. Statistical analysis was performed with Student's T test, considering p < 0.05 as significant. Results: The RFA plus TNF alpha nanoparticle group had a larger zone of complete cell death than the RFA-only group (0.30 ± 0.07 vs 0.23 ± 0.03 mL, P=.03). The zone of partially ablated tissue was smaller in the RFA plus TNF alpha nanoparticle group than in the RFA-only group (0.08 ± 0.02 vs 0.13 ± 0.05 mL, P =.01). Conclusions: We have demonstrated the efficacy of TNF alpha nanoparticle in enhancing RFA in a translational kidney tumor model. The potential usage of TNF alpha nanoparticle to improve RFA of renal cell carcinoma merits further study
Doutorado
Fisiopatologia Cirúrgica
Doutor em Ciências
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Books on the topic "Experimental tumor"

1

Tumor models in cancer research. 2nd ed. New York: Humana Press, 2011.

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Beniashvili, Dzhemali Sh. Experimental tumors in monkeys. Boca Raton: CRC, 1994.

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Nicholas, Davies. Octreotide and experimental liver tumour. Edinburgh: University of Edinburgh, 1993.

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Horst, Wenker, ed. Spinal cord tumors ; Experimental neurosurgery ; Neurosurgical intensive care. Berlin: Springer-Verlag, 1986.

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Wenker, Horst, Margareta Klinger, Mario Brock, and Friedrich Reuter, eds. Spinal Cord Tumors Experimental Neurosurgery Neurosurgical Intensive Care. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71108-4.

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Xanthines and cancer: An experimental study of tumour inhibition. Aberdeen: Aberdeen University Press, 1988.

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Meijnders, Paul Joseph Nikolas. The application of rat lung tumour models in experimental therapy of bronchial cancer =: Toepassing van rattenlongtumormodellen in experimentele therapie van longkanker. [Leiden: University of Leiden], 1998.

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United Kingdom Co-ordinating Committee on Cancer Research. UKCCCR guidelines for the welfare of animals in experimental neoplasia. 2nd ed. London: UKCCCR, 1997.

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R, Welch D., and Burger Max M, eds. Cancer metastasis: In vitro and in vivo experimental approaches. Amsterdam: Elsevier, 2000.

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Oncology, Workshop (1st 1983 Ludwigsburg Germany). New aspects in physiological antitumor substances: Experimental and clinical studies with xenogenic peptides and proteins. Basel ; New York: Karger, 1985.

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Book chapters on the topic "Experimental tumor"

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Chen, Zhen-Guo, Barbara Bottazzi, Ji-Ming Wang, and Alberto Mantovani. "Tumor-Associated Macrophages in Metastasizing Tumors." In Advances in Experimental Medicine and Biology, 61–71. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-5037-6_8.

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Martínez, Carlos H., Sumit Dave, and Jonathan Izawa. "Wilms’ Tumor." In Advances in Experimental Medicine and Biology, 196–209. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6448-9_18.

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Thompson, Patricia L., and Sophie Dessureault. "Tumor Cell Vaccines." In Advances in Experimental Medicine and Biology, 345–55. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-72005-0_37.

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Bermudes, David, Brooks Low, and John Pawelek. "Tumor-Targeted Salmonella." In Advances in Experimental Medicine and Biology, 57–63. New York, NY: Springer US, 2002. http://dx.doi.org/10.1007/0-306-46817-4_6.

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Otto, T., G. Lümmen, A. Be, H. Rubben, and A. Raz. "Tumor Cell Motility." In Advances in Experimental Medicine and Biology, 469–76. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4737-2_36.

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Rojas, Armando, Paulina Araya, Ileana Gonzalez, and Erik Morales. "Gastric Tumor Microenvironment." In Advances in Experimental Medicine and Biology, 23–35. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-36214-0_2.

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Verdelli, Chiara, Valentina Vaira, and Sabrina Corbetta. "Parathyroid Tumor Microenvironment." In Advances in Experimental Medicine and Biology, 37–50. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-36214-0_3.

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Zewdu, Abbie, Lucia Casadei, Raphael E. Pollock, and Danielle Braggio. "Adipose Tumor Microenvironment." In Advances in Experimental Medicine and Biology, 73–86. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-36214-0_6.

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Roncati, Luca, Paolo Gasparri, Graziana Gallo, Giuditta Bernardelli, Giuliana Zanelli, and Antonio Manenti. "Appendix Tumor Microenvironment." In Advances in Experimental Medicine and Biology, 87–95. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-36214-0_7.

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Cerottini, Jean-Charles, D. Valmori, D. Rimoldi, and P. Romero. "Human Tumor Immunotherapy." In Advances in Experimental Medicine and Biology, 247–50. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5357-1_40.

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Conference papers on the topic "Experimental tumor"

1

Attaluri, Anilchandra, Ronghui Ma, and Liang Zhu. "Temperature Elevations in Implanted Prostatic Tumors in Mice During Magnetic Nanoparticle Hyperthermia: In Vivo Experimental Study." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53128.

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In this study, we perform in vivo animal experiments on implanted prostatic tumors in mice to measure temperature elevation distribution in the tumor during magnetic nanoparticle hyperthermia. Temperature rises are induced by a commercially available ferrofluid injected to the center of the tumor, which is subject to an alternating magnetic field. Temperature mapping in the implanted prostatic tumors during the heating has illustrated the feasibility of elevating the tumor temperature higher than 50°C using only 0.1 cc ferrofluid injected in the tumor and under a relatively low magnetic field (3 kA/m). Ferrofluid infusion rates during intratumoral injection may affect nanoparticle spreading in tumors. Using a very slow infusion rate of 5 μ1/min results in an average temperature elevation in tumors 27°C above the baseline temperatures of 37°C. However, the temperature elevations are barely 14°C when the infusion rate is 20 μl/min. Our results suggest a more confined nanoparticle distribution to the injection site using smaller infusion rates.
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Wu, Jie, Shixiong Xu, and Quan Long. "Study of Tumor Microenvironment to Vascular Normalization Based on 3-D Simulation of Tumor Haemodynamics." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204675.

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In recent years, anti-angiogenic therapy has been extensively studied in both preclinical and clinical settings. Experimental studies have approved its effects on the normalization of tumor vasculature as well as the microenvironment in tumors [1]. However, little is known about how tumor microenvironment is affected by the changes in structure of vasculature or transport properties of vessels and interstitium that are associated with anti-angiogenic therapy, since the experimental data are difficult to obtain [2].
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Blattmann, Hans. "Tumor therapy with heavy charged particles." In Experimental nuclear physics in europe: Facing the next millennium. AIP, 1999. http://dx.doi.org/10.1063/1.1301839.

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Manuchehrabadi, Navid, Yonghui Chen, Alexander LeBrun, Ronghui Ma, and Liang Zhu. "Theoretical Simulation of Temperature Elevations in Tumors Using Monte Carlo Method and Comparison to Experimental Measurements During Laser Photothermal Therapy." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14330.

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Nanotechnology using gold nanoshells or nanorods is a newly developed hyperthermia approach and has been tested in the past several years in cancer treatment.1–2 Gold nanorods have a diameter of ∼10 nm and an aspect ratio of approximately four. By varying the geometric ratio, the nanostructures can be tuned to have strong absorption and scattering to a specific laser wavelength. Designing an optimal treatment protocol of laser photothermal therapy requires understanding of gold nanorod deposition inside the tumor after injection, its resulted specific absorption rate (SAR) distribution, and the ultimate temperature field in the tumor during the treatment. Recent microCT studies by our group have suggested that the gold nanorod solution injected into PC3 prostatic tumors results in an almost uniform distribution of the gold nanorods in the tumors.3 The Monte Carlo method has been used in the past to determine the heating pattern (SAR) of laser-tissue thermal interaction.4 However, the accuracy of the theoretical simulation of the temperature fields in tumors relies on precise measurements of the optical properties of the tumors with nanorods presence.
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Singh, Manpreet, Qimei Gu, Ronghui Ma, and Liang Zhu. "Temperature Distribution and Thermal Dosage Affected by Nanoparticle Distribution in Tumours During Magnetic Nanoparticle Hyperthermia." In ASME 2019 6th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/mnhmt2019-4233.

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Abstract Recent microCT imaging study has demonstrated that local heating caused a much larger nanoparticle distribution volume in tumors than that in tumors without localized heating, suggesting possible nanoparticle redistribution/migration during heating. In this study, a theoretical simulation is performed to evaluate to what extent the nanoparticle redistribution affects the temperature elevations and thermal dosage required to cause permanent thermal damage to PC3 tumors. Two tumor groups with similar sizes are selected. The control group consists of five PC3 tumors with nanoparticles distribution without heating, while the experimental group consists of another five resected PC3 tumors with nanoparticles distribution obtained after 25 minutes of local heating. Each generated tumor model is attached to a mouse body model by microCT scans. A previously determined relationship between the nanoparticle concentration distribution and the volumetric heat generation rate is implemented in the theoretical simulation of temperature elevations during magnetic nanoparticle hyperthermia. Our simulation results show that the average steady state temperature elevation in the tumors of the control group is higher than that in the experimental group when the nanoparticles are more spreading from the tumor center to tumor periphery (control group: 64.03±3.2°C vs. experimental group: 62.04±3.07°C). Further we assess the thermal dosage needed to cause 100% permanent thermal damage (Arrhenius integral Ω = 4) to the entire tumor, based on the assumption of unchanged nanoparticle distribution during heating. The average heating time based on the experimental setting from our previous studies demonstrates significantly different designs. Specifically, the average heating time for the control group is 24.3 minutes. However, the more spreading of nanoparticles to tumor periphery in the experimental group results in a much longer heating time of 38.1 minutes, 57° longer than that in the control group, to induce permanent thermal damage to the entire tumor. The results from this study suggest that the heating time needed when considering dynamic nanoparticle migration during heating is probably between 24 to 38 minutes. In conclusion, the study demonstrates the importance of including dynamic nanoparticle spreading during heating into theoretical simulation of temperature elevations in tumors to determine accurate thermal dosage needed in magnetic nanoparticle hyperthermia design.
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Manuchehrabadi, N., R. Toughiri, H. Cai, L. Zhu, A. Attaluri, R. Edziah, E. Lalanne, R. Ma, A. M. Johnson, and C. Bieberich. "Treatment Efficacy of Laser Photothermal Therapy Using Gold Nanorods: Tumor Shrinkage Study." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80625.

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Gold nanorods can be tuned to a specific laser wavelength and serve as strong laser energy absorbers. Due to the powerful optical absorption, the laser energy is concentrated in an area congregating by nanorods, and then the energy absorbed can be transferred to the surrounding tumor tissue by heat conduction.1–4 Previous studies have shown a wide range of heating parameters with or without temperature measurements. Our previous experiment4 has demonstrated that using only 0.1 cc gold nanorod solution can lead to tumor temperature higher than 50°C when the laser irradiance is only 2 W/cm2. Based on the measured temperature elevation and heating duration, thermal damage to the tumor is highly likely. However, some researchers raised the question whether temperature sensors used in those experimental studies are truly reflecting the temperatures in the tumors. The objective of this study is to measure quantitatively tumor shrinkage after laser irradiation to evaluate efficacy of laser photothermal therapy.
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He, Zhi Zhu, and Jing Liu. "Investigation of Tumor Growth Based on Phase Field Model." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-65744.

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This paper presents and investigates the tumor growth based on a phase model. The tumor core is necrotic and inhibitor chemical species are considered. The interface of tumor and health tissue is tracked using a phase field equation. The reformulation of a classical model, accounting for cell-proliferation, apoptosis, cell-to-cell and cell-to-matrix adhesion, is derived. The advantages of the finite difference methodology employed are generality and relative simplicity implication. We present simulations of the nonlinear evolution of growing tumors morphology and discuss the effects of tumor microenvironment. Mechanisms reflecting the tumor growth and development behavior was preliminarily interpreted. Recently numerous mathematical have been developed to investigate the growth dynamics of tumor [1–8]. One of most significant model developed by Wise [8] is based on Cahn-Hilliard equation, which is conservation phase field method. Allen-Chan nonconservation phase field has been developed to track the moving interface for multiphase simulation by Sun [9]. Allen-Chan equation is second order, while Cahn-Hilliard equation is fourth order in space. Thus, we introduce the Allen-Chan phase method [9–10] to simulate the tumor growth, which is very simple for numerical simulation The computation domain is illustrated in Fig. 1, where ΩH denotes host tissue, the tumor domains is comprised of viable tumor cell ΩV and dead tumor cell ΩD. The numerical results are presented at Fig. (2–4). One can find that the growth of tumor strongly depend on the nutrients and nonlinear unstable growth may lead to finger shaped pattern, which is in agreement with recent experimental observations [7] of in vivo tumor. In summary, a phase method has been developed to study diffusion and consumption of the nutrients and tumor cell proliferation, necrosis and migration, which discloses the evolution of complex shape of tumor.
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Jingfbai Bai, Guoxin Ren, Yazhu Chen, and Wei Guo. "Experimental Study on Ultrasonic Thermal Chemotherapy for Tumor Treatment." In 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1616061.

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Xu, Jian, Jing Zhu, and Shu-Dong Xiao. "Experimental study o f hematoporphyrin derivative in tumor diagnosis." In 1997 Shanghai International Conference on Laser Medicine and Surgery, edited by Jing Zhu. SPIE, 1998. http://dx.doi.org/10.1117/12.330167.

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Chambers, AF. "Abstract ES7-2: Tumor Dormancy from an Experimental Biologist's Perspective." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-es7-2.

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Reports on the topic "Experimental tumor"

1

Research, Gratis. The New Field of Ferroptosis Research: Ongoing Developments and Future Outlook. Gratis Research, March 2021. http://dx.doi.org/10.47496/gr.blog.12.

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Although some experiments have found some proteins that play a regulatory role in ferroptosis, it is still expected to find specific markers for the occurrence of ferroptosis, creating new opportunities for tumor diagnosis and therapeutic intervention
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Rabkin, Samuel D. Therapy of Experimental Nerve Sheath Tumors Using Oncolytic Viruses. Fort Belvoir, VA: Defense Technical Information Center, June 2005. http://dx.doi.org/10.21236/ada437952.

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Kurtz, Andreas. Therapy of Experimental Nerve Sheath Tumors Using Oncolytic Viruses. Fort Belvoir, VA: Defense Technical Information Center, June 2003. http://dx.doi.org/10.21236/ada417108.

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Sinpurwalla, Nozer D., and Jingxian Chen. Filtering, Smoothing, and Extrapolations in Dose-Response Experiments: With Application to Data on Respiratory Tumor in Rats. Fort Belvoir, VA: Defense Technical Information Center, January 1990. http://dx.doi.org/10.21236/ada293968.

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Moolgavkar, S. H. [Initiation, promotion, initiation experiments with radon and cigarette smoke: Lung tumors in rats]. Progress report. Office of Scientific and Technical Information (OSTI), October 1994. http://dx.doi.org/10.2172/10185044.

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Campodonico, Sylvia, and Jingxian Chen. A Computer Program for 'Filtering, Smoothing, Extrapolation in Dose-Response Experiments With Application to Data on Respiratory Tumor of Rats',. Fort Belvoir, VA: Defense Technical Information Center, June 1989. http://dx.doi.org/10.21236/ada293862.

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Immunobiology of experimental host-tumor relationships in osteogenic malignancies. Office of Scientific and Technical Information (OSTI), January 1990. http://dx.doi.org/10.2172/6983334.

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Research in radiobiology: Final report of work in progress in immunobiology of experimental host-tumor relationships. Office of Scientific and Technical Information (OSTI), March 1993. http://dx.doi.org/10.2172/10139426.

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Research in radiobiology: Final report of work in progress in immunobiology of experimental host-tumor relationships. Office of Scientific and Technical Information (OSTI), March 1993. http://dx.doi.org/10.2172/6649356.

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