Academic literature on the topic 'Exposomics'

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Journal articles on the topic "Exposomics"

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Neagu, Anca-Narcisa, Taniya Jayaweera, Lilian Corrice, Kaya Johnson, and Costel Darie. "Breast Cancer Exposomics." Life 14, no. 3 (2024): 402. http://dx.doi.org/10.3390/life14030402.

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We are exposed to a mixture of environmental man-made and natural xenobiotics. We experience a wide spectrum of environmental exposure in our lifetime, including the effects of xenobiotics on gametogenesis and gametes that undergo fertilization as the starting point of individual development and, moreover, in utero exposure, which can itself cause the first somatic or germline mutation necessary for breast cancer (BC) initiation. Most xenobiotics are metabolized or/and bioaccumulate and biomagnify in our tissues and cells, including breast tissues, so the xenobiotic metabolism plays an importa
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Miller, Gary W., L. Michelle Bennett, David Balshaw, et al. "Integrating exposomics into biomedicine." Science 388, no. 6745 (2025): 356–58. https://doi.org/10.1126/science.adr0544.

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Casella, V., M. Franzini, M. T. Rocca, et al. "CUSTOMIZED WEBGIS SOLUTIONS FOR EXPOSOMICS." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLIII-B3-2020 (August 22, 2020): 1431–38. http://dx.doi.org/10.5194/isprs-archives-xliii-b3-2020-1431-2020.

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Abstract. Exposomics is a science aiming at quantifying the effects on human health of all the factors influencing it, but genetic ones. They include environment, food, mobility habits and cultural factors. The percentage of the world’s population living in the urban areas is projected to increase in the next decades. Rising industrialization, urbanization and heterogeneity are leading to new challenges for public health and quality of life in the population. The prevalence of conditions such as asthma and cardiovascular diseases is increasing due to a change in lifestyle and air quality. This
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Turner, Michelle C., Paolo Vineis, Eduardo Seleiro, et al. "EXPOsOMICS: final policy workshop and stakeholder consultation." BMC Public Health 18, no. 1 (2018): 260. https://doi.org/10.1186/s12889-018-5160-z.

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<strong>Abstract: </strong>The final meeting of the EXPOsOMICS project "Final Policy Workshop and Stakeholder Consultation" took place 28–29 March 2017 to present the main results of the project and discuss their implications both for future research and for regulatory and policy activities. This paper summarizes presentations and discussions at the meeting related with the main results and advances in exposome research achieved through the EXPOsOMICS project; on other parallel research initiatives on the study of the exposome in Europe and in the United States and their complementarity to EXP
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Chen, Minjian. "Environmental Chemical Exposomics and Metabolomics in Toxicology: The Latest Updates." Toxics 12, no. 9 (2024): 647. http://dx.doi.org/10.3390/toxics12090647.

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Choi, Hyunok, Mark T. McAuley, and David A. Lawrence. "Prenatal exposures and exposomics of asthma." AIMS Environmental Science 2, no. 1 (2015): 87–109. http://dx.doi.org/10.3934/environsci.2015.1.87.

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Lein, Pamela J. "Exposomics: A shift in biomedical research with potential to improve human health." Open Access Government 44, no. 1 (2024): 120–21. http://dx.doi.org/10.56367/oag-044-10177.

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Exposomics: A shift in biomedical research with potential to improve human health Recent advances in exposomics offer an exciting opportunity to comprehensively catalog human exposures and link them to biological responses determining health and disease. Pamela J. Lein, Ph.D. from the University of California, tells us more. The sequencing of the human genome was heralded as a major scientific achievement that would revolutionize medicine by identifying genetic causes of disease, which could then be cured using gene therapy. However, while genomic research has identified numerous genetic varia
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Jobst, Karl J., and Krystal Godri Pollitt. "Editorial overview: Exposomics, emerging exposures and analytical challenges." Current Opinion in Environmental Science & Health 15 (June 2020): A1—A3. http://dx.doi.org/10.1016/j.coesh.2020.08.001.

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Cooke, Marcus S., Chiung-Wen Hu, Yuan-Jhe Chang, and Mu-Rong Chao. "Urinary DNA adductomics – A novel approach for exposomics." Environment International 121 (December 2018): 1033–38. http://dx.doi.org/10.1016/j.envint.2018.10.041.

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Fan, Jung-wei, Jianrong Li, and Yves A. Lussier. "Semantic Modeling for Exposomics with Exploratory Evaluation in Clinical Context." Journal of Healthcare Engineering 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/3818302.

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Exposome is a critical dimension in the precision medicine paradigm. Effective representation of exposomics knowledge is instrumental to melding nongenetic factors into data analytics for clinical research. There is still limited work in (1) modeling exposome entities and relations with proper integration to mainstream ontologies and (2) systematically studying their presence in clinical context. Through selected ontological relations, we developed a template-driven approach to identifying exposome concepts from the Unified Medical Language System (UMLS). The derived concepts were evaluated in
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Dissertations / Theses on the topic "Exposomics"

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Fan, Jung-wei, Jianrong Li, and Yves A. Lussier. "Semantic Modeling for Exposomics with Exploratory Evaluation in Clinical Context." HINDAWI LTD, 2017. http://hdl.handle.net/10150/625835.

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Exposome is a critical dimension in the precision medicine paradigm. Effective representation of exposomics knowledge is instrumental to melding nongenetic factors into data analytics for clinical research. There is still limited work in (1) modeling exposome entities and relations with proper integration to mainstream ontologies and (2) systematically studying their presence in clinical context. Through selected ontological relations, we developed a template-driven approach to identifying exposome concepts from the Unified Medical Language System (UMLS). The derived concepts were evaluated in
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Matta, Komodo. "Study of the associations between exposure to endocrine disrupting chemicals and endometriosis : an integrative approach." Electronic Thesis or Diss., Nantes, Ecole nationale vétérinaire, 2021. http://www.theses.fr/2021ONIR155F.

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Les humains sont exposés quotidiennement à des mélanges complexes de polluants chimiques, dont certains sont susceptibles de perturber nos fonctions endocriniennes et de contribuer à des maladies reproductives comme l'endométriose. L'endométriose est une maladie peu connue qui touche environ 5 à 15 % des personnes ayant leurs règles. Elle se caractérise par la présence de tissus endométriaux en dehors de l'utérus, et peut présenter des symptômes graves et coûteux. Malgré les preuves épidémiologiques de plus en plus nombreuses qui confirment l'association entre certains produits chimiques pertu
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Ku, Mei-Sheng, and 古玫生. "Fetal Exposomes and Child Development: Using DNA Methylation Levels of Imprinted Genes as an Indicator." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/4jr2f5.

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碩士<br>國立臺灣大學<br>環境衛生研究所<br>103<br>Background In utero exposures have been suggested to be linked to adverse birth outcomes, neurodevelopment or child behavior, but the underlying mechanism remains elusive. DNA methylation, an essential epigenetic modification, of candidate imprinted genes might provide a quantitative screening marker for the effects of prenatal exposures on the development and neurobehavioral development of the infants, even the risk of developing certain disease in later life. Objective The objective of this study is to investigate the relationship between multiple fetal expo
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Chen, Chi-Hsin Sally, and 陳其欣. "Exposomic study on the association between multiple pollutants exposure and metabolome in residents living near No. 6 Naphtha Cracking Complex." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/5sx28k.

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博士<br>國立臺灣大學<br>職業醫學與工業衛生研究所<br>107<br>Background: Exposomics is an important methodology in environmental health research. Recently, a branching paradigm, the Public Health Exposome Approach, focuses on the impact of exposures on the overall health of a population within a particular region. This dissertation focuses on the exposomics study of residents living near No. 6 Naphtha Cracking Complex, the largest petrochemical complex in Taiwan, and aim to clarify the association between exposure levels, metabolome, and early health effect biomarkers. Material and Methods: We classified 273 study
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Book chapters on the topic "Exposomics"

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Dagnino, Sonia, and Jessica Laine. "Exposomics and Environmental Monitoring." In Toxicology for the Health and Pharmaceutical Sciences. CRC Press, 2021. http://dx.doi.org/10.1201/9780203730584-20.

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Maitre, Léa, and Martine Vrijheid. "Exposomics: The Exposome in Early Life." In Health Impacts of Developmental Exposure to Environmental Chemicals. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0520-1_18.

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Demetriou, Christiana A., Davide Degli Esposti, Kristi Pullen Fedinick, and Paolo Vineis. "EXPOsOMICs: Meet-in-the-Middle and Network Perturbation." In Unraveling the Exposome. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89321-1_14.

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Hernandes, Vinicius Verri, and Benedikt Warth. "Modular, Scalable, and Customizable LC-HRMS for Exposomics." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-4116-3_3.

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Smith, Martyn T., Cliona M. McHale, and Rosemarie de la Rosa. "Using Exposomics to Assess Cumulative Risks from Multiple Environmental Stressors." In Unraveling the Exposome. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89321-1_1.

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Guchet, Xavier. "Exposomics in the Era of Personalized Medicine: A Critical Analysis." In Personalized Medicine in the Making. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-74804-3_11.

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Duarte-Hospital, Carolina, and Gary W. Miller. "Using Exposomics to Advance Neurotoxicology." In Reference Module in Biomedical Sciences. Elsevier, 2025. https://doi.org/10.1016/b978-0-323-95488-4.00290-4.

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Robinson, Oliver, Paolo Vineis, and Giovanni Fiorito. "Capturing exposures from childhood to adulthood with exposomics." In A Life Course Approach to the Epidemiology of Chronic Diseases and Ageing, 3rd ed. Oxford University PressOxford, 2025. https://doi.org/10.1093/oso/9780198895961.003.0004.

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Abstract In this chapter, we present an overview of the concept of the exposome, including its definitions and applications within the context of life course epidemiology. We describe the relevance of life course models to the interpretation of exposome research. We present and provide examples of external exposome research such as through assessment of the ‘urban exposome’ and the role of internal exposome research for exposure assessment and epidemiology, through examples such as untargeted metabolomics, mutational signatures, and DNA surrogate markers. Finally, we provide some future perspe
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Raghavan, Ramya, and Shadab Ahamad. "Developmental Origins of Health and Disease." In Cancer Exposomics and Environmental Influences on Carcinogenesis. IGI Global, 2025. https://doi.org/10.4018/979-8-3373-2165-3.ch001.

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There is an intricate relationship between the exposome and critical periods of gametogenesis, teratogenesis, and cancer development. Developmental Origins of Health and Disease (DOHaD) framework to cancer susceptibility examines the hypothesis that early-life environmental exposures can program long-term cancer risk. The authors review epidemiological studies demonstrating associations between developmental exposures and increased cancer risk. Case studies beginning from gametogenesis, debates on biological mechanisms, epigenetic modifications, and altered tissue development are discussed. Th
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A. P., Divya, Mahalakshmi K. M., Sai Priyanka J., and Ramya Raghavan. "The Cancer Exposome." In Cancer Exposomics and Environmental Influences on Carcinogenesis. IGI Global, 2025. https://doi.org/10.4018/979-8-3373-2165-3.ch004.

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Gene-environment interactions play a crucial role in tumor initiation by influencing cellular and tissue plasticity. Environmental and internal factors influence carcinogenesis by acting on specific sensing genes and pathways, leading to epigenetic, genetic, and metabolic changes that shape the TME. Understanding the exposome can inform gene expression, epigenetic changes, and immune responses, particularly for the reproductive health and cancer prevention. The authors discuss the latest methodologies in exposome assessment, challenges in defining and measuring harmful environmental impacts. E
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Conference papers on the topic "Exposomics"

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GARAO RICO, ANDRE LUIS, NICOLE PALMIERO, MARYLYN D. RITCHIE, and MOLLY A. HALL. "Integrated exposomic analysis of lipid phenotypes: Leveraging GE.db in environment by environment interaction studies." In Pacific Symposium on Biocomputing 2025. WORLD SCIENTIFIC, 2024. http://dx.doi.org/10.1142/9789819807024_0038.

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Gouripeddi, Ramkiran, Le-Thuy Tran, Randy Madsen, et al. "An Architecture for Metadata-driven Integration of Heterogeneous Sensor and Health Data for Translational Exposomic Research." In 2019 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI). IEEE, 2019. http://dx.doi.org/10.1109/bhi.2019.8834657.

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