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Dissertations / Theses on the topic 'Expression QTL'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Prashar, Ankush. "Arabidopsis QTL analysis using stairs and gene expression." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435316.

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2

Laere, Anne-Sophie van. "From QTL to QTN : identification of a quantitative trait nucleotide influencing muscle development and fat deposition in pig /." Uppsala : Dept. of Animal Breeding and Genetics, Swedish Univ. of Agricultural Sciences, 2005. http://epsilon.slu.se/200509.pdf.

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3

Grace, Christopher Philip. "Detection and exploitation of expression QTL in drug discovery and development." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:7b174e64-d17f-4e2c-b366-065684bfd813.

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Expression quantitative trait loci (eQTLs) are genetic markers associated with transcription of Ribonucleic Acid (RNA). eQTLs are detected using association analysis to detect correlations between RNA expression data (microarray or RNA-SEQ) and the genotypes of individuals within a study. Trans-ethnic meta-analysis can increase power to detect genetic variants for eQTLs and improve fine-mapping resolution because of differential patterns of linkage disequilibrium (LD) between diverse populations. Lymphoblastoid cell lines (LCLs) from samples in the Phase II and III HapMap populations have been

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4

Perera, Suriya Arachchige Chandrika Nishanthi. "Fine mapping of QTL and microarray gene expression studies in arabidopsis using STAIRS." Thesis, University of Birmingham, 2005. http://etheses.bham.ac.uk//id/eprint/1652/.

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QTL mapping with segregating populations results in poor map resolution which limits the applicability of mapped QTL in further research such as gene cloning. The current research project aimed mainly at developing STepped Aligned Recombinant Inbred Strains (STAIRS) covering the top region of chromosome 3 and demonstrating the feasibility of using STAIRS in high resolution mapping of QTL in Arabidopsis. The top region of chromosome 3 of Arabidopsis had been reported to house QTL related to flowering time. This region was first saturated with 24 polymorphic microsatellite markers and 23 narrow

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5

McSweeny, Andrew J. "Identification of Candidate Genes within Blood Pressure QTL Containing Regions Using Gene Expression Data." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1212501779.

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6

Guitton, Baptiste. "Genetic control of biennial bearing in apple." Thesis, Montpellier, SupAgro, 2011. http://www.theses.fr/2011NSAM0048.

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L'alternance de production est définie comme la charge en fruit d'un arbre irrégulière sur plusieurs années consécutives. La principale hypothèse en soulignant l'alternance est que la charge en fruits d'une année en cours inhibe la formation de fleurs pour l'année suivante. Ce phénomène génère d'importants problèmes agronomiques pour les espèces fruitières comme le pommier, en réduisant la production de fruits au cours des années 'OFF' et la qualité des fruits au cours des années 'ON', tout en augmentant les coûts de gestion des vergers, en particulier pour l'éclaircissage des fruits. Une stra

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7

Santos, Michelle da Fonseca. "Mapeamento de QTL e expressão gênica associados à resistência da soja ao complexo de percevejos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-16082012-083347/.

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O grupo de percevejos que mais frequentemente causa perdas econômicas à soja no Brasil é composto pelas espécies: Nezara viridula, Piezodorus guildinii e Euchistus heros. Assim, os objetivos desta pesquisa foram avaliar parâmetros genéticos e correlações entre as diferentes características de desenvolvimento e produção, mapear QTL associados à resistência da soja aos percevejos e determinar respostas de expressão gênica associadas à alimentação do inseto. Uma população F2:3 foi desenvolvida através do cruzamento de IAC- 100 (resistente) e CD-215 (suscetível) e avaliada em campo experimental. A

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8

Pumphrey, Michael Odell. "Towards map-based cloning of Fusarium head blight resistance QTL Fhb1 and non-additive expression of homoeologous genes in allohexaploid wheat." Diss., Kansas State University, 2007. http://hdl.handle.net/2097/32793.

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Doctor of Philosophy<br>Department of Plant Pathology<br>Bikram S. Gill<br>Wheat is the most widely grown and consumed grain crop in the world. In order to meet future agricultural production requirements of a growing population, it is essential that we achieve an increased understanding of the basic components and mechanisms shaping growth and productivity of the polyploid wheat plant. Fusarium head blight (FHB) (syn. "scab") poses a serious threat to the quantity and safety of the world's food supply. The resistance locus Fhb1 has provided partial resistance to FHB of wheat for nearly four d

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9

Nguyen, Le Khanh. "Caractérisation fonctionnelle d'un QTL de développement racinaire détecté par GWAS dans une collection de variétés vietnamiennes de riz." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTG044.

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Le riz est l'une des céréales les plus importantes au monde. Au Vietnam, le riz est également considéré comme un produit agronomique clé pour l'exportation. Cependant, le stress dû à la sécheresse menace la production de riz de plus en plus fréquemment et sur de plus longues périodes. Les racines coronaires constituent une partie importante du système racinaire du riz et jouent un rôle crucial dans le maintien du rendement en cas de sécheresse. Le nombre de racines coronaires affecte la biomasse de racines et détermine la capacité de la plante à extraire les ressources du sol. Un QTL de NRC, q

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10

Rubin, Carl-Johan. "Functional Genomics of Bone Metabolism : Novel Candidate Genes Identified by Studies in Chicken Models." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8498.

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<p>Osteoporosis is a disease that leads to decreased bone mineral density (BMD), an altered bone micro-architecture and fragile bones. The disease is highly heritable and numerous genes are thought to be involved, making it difficult to identify the causative genetic elements.</p><p>Animal models, mainly intercrosses between laboratory strains of mice, have been succesfully used to map genes affecting these traits, but may not mirror the multifactorial genetic etiology of highly complex traits such as osteoporosis.</p><p>Over the course of tens of thousand years humans have kept domestic anima

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11

Castede, Sophie. "Génétique moléculaire de la floraison chez le cerisier doux : étude et compréhension du déterminisme génétique et moléculaire de la floraison chez le cerisier (Prunus avium) en vue de son adaptation aux futures conditions climatiques." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0312/document.

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Chez les espèces fruitières, la floraison est un évènement majeur qui influencera fortement la fructification. Ce processus, finement régulé par de nombreux facteurs génétiques et environnementaux, est encore peu connu. Chez le cerisier doux (Prunus avium), les fleurs ne s’épanouissent qu’après avoir satisfait des besoins en froid et en chaud. Les effets du changement climatique sur la floraison sont déjà notables et pourraient induire d’importantes pertes économiques. La compréhension des déterminants génétiques et moléculaires impliqués dans la floraison permettra l’amélioration des programm

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12

Sallé, Guillaume. "Détection et validation fonctionnelle de régions du génome affectant la résistance aux strongles gastro-intestinaux chez le mouton." Thesis, Toulouse, INPT, 2012. http://www.theses.fr/2012INPT0154/document.

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Les strongles gastro-intestinaux, dont Haemonchus contortus constituent un problème majeur pour l'élevage des ovins allaitants. Ils entrainent des pertes de production et le recours aux anthelminthiques est remis en question par l'apparition de souches de vers résistantes. La sélection d'ovins plus résistants fait partie des stratégies complémentaires de lutte les plus sérieuses. Cependant sa mise en oeuvre requiert une meilleure compréhension des mécanismes sous-jacents. Cette thèse vise à identifier les régions du génome ovin impliquées dans la résistance aux strongles gastro-intestinaux. Un

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13

Castro, Quezada Patricio Salvador. "Analyse fonctionnelle et étude de la régulation de gènes candidats sous-jacents au QTL GpaVspl impliqué dans la résistance au nématode à kyste Globodera pallida chez la pomme de terre." Phd thesis, Université d'Avignon, 2013. http://tel.archives-ouvertes.fr/tel-00991628.

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Les nématodes à kystes sont l'un des bioagresseurs causant le plus de dégâts sur les cultures de pommes de terre. La résistance trouvée chez l'accession spl88S.329.18, issue de l'espèce Solanum sparsipilum est caractérisée par un déterminisme oligogénique avec un QTL à localisé sur le chromosome V (GpaVspl) et un QTL mineur localisé sur le chromosome XI(GpaXIspl). Pour obtenir une résistance de haut niveau, l'effet du QTL GpaVspl, doit êtrecomplémenté par celui du QTL à effet faible GpaXIspl. Par génomique comparative, le locusGpaV a été localisé dans un intervalle compris entre 16 et 60 kb su

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14

Joehanes, Roby. "Generalized and multiple-trait extensions to Quantitative-Trait Locus mapping." Diss., Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/1919.

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15

Harrang, Estelle. "Apport des informations moléculaires et cellulaires pour la caractérisation de la résistance de l'huître plate européenne vis-à-vis de la bonamiose, et pour la détection de signatures de la sélection naturelle." Phd thesis, Université de La Rochelle, 2012. http://tel.archives-ouvertes.fr/tel-00840222.

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L'huître plate européenne, espèce endémique des côtes européennes, est classée dans la catégorie des " espèces menacées et/ou en déclin ". En effet, les gisements naturels de cette huître ont été progressivement décimés par la sur-exploitation et par l'émergence successive de maladies parasitaires. Le parasite responsable de la bonamiose a notamment contribué à réduire de façon drastique l'exploitation de cette huître en France, et en Europe. Les mollusques bivalves marins présentent deux caractéristiques qui restreignent de fait le potentiel d'action pour lutter contre les maladies : ils sont

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16

Fallahshahroudi, Amir. "Domestication Effects on the Stress Response in Chickens : Genetics, Physiology, and Behaviour." Doctoral thesis, Linköpings universitet, Biologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-137350.

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Animal domestication, the process where animals become adapted to living in proximity to humans, is associated with the alteration of multiple traits, including decreased fearfulness and stress response. With an estimated population of 50 billion, the domesticated chicken is the most populous avian species in the world. Hundreds of chicken breeds have been developed for meat and egg production, hobby or research purposes. Multidirectional selection and the relaxation of natural selection in captivity have created immense phenotypic diversity amongst domesticates in a relatively short evolution

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17

Soratto, Tatiany Aparecida Teixeira. "Mapeamento de QTLs e eQTLs associados à reação a “Candidatus Liberibacter asiaticus” em Poncirus trifoliata, Citrus sunki e híbridos." Universidade Federal de São Carlos, 2017. https://repositorio.ufscar.br/handle/ufscar/9363.

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Submitted by Tatiany Aparecida Teixeira Soratto (tatiany_soratto@hotmail.com) on 2017-10-31T12:37:37Z No. of bitstreams: 2 DISSERTACAO_Tatiany_final.pdf: 3171924 bytes, checksum: 81e554e8e0137d88785acf8a80455d32 (MD5) Encaminhamento do orientador.pdf: 236358 bytes, checksum: 344f7f279720c6058970c50ae22f4a46 (MD5)<br>Approved for entry into archive by Alini Demarchi (alini@cca.ufscar.br) on 2017-11-30T14:04:32Z (GMT) No. of bitstreams: 2 DISSERTACAO_Tatiany_final.pdf: 3171924 bytes, checksum: 81e554e8e0137d88785acf8a80455d32 (MD5) Encaminhamento do orientador.pdf: 236358 bytes, checksum: 3

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18

Cairns, Jill Elizabeth. "Analysis of environmental effects on expression of root penetration QTLs in upland rice." Thesis, University of Aberdeen, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288341.

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In the first year, two upland rice varieties (Azucena and Bala), were screened for root response to drought at the West Africa Rice Development Association (WARDA), Cote d’Ivoire, in two fields of slightly different soil penetration resistance (PR) characteristics. Changes in soil PR and soil water content were monitored during the drought period. Root density and depth were significantly greater for Azucena than Bala, and on the irrigated plots compared to the droughted plots, although no consistent site differences in root density were observed. At each site, on the droughted subplot, soi

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19

Lakin, Nicholas David. "The regulation of actin gene expression in Xenopus embryos." Thesis, University of Warwick, 1991. http://wrap.warwick.ac.uk/108299/.

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The main aim of this work was to identify the important cis-acting regulatory sequences, and the trans-acting factors with which they interact, which are required for the tissue-specific expression of the Xenopus borealis skeletal actin gene. All sequences necessary and sufficient for the correct spatial and temporal expression of the Xenopus borealis skeletal actin gene are located in a 156 bp fragment of the gene that spans from nucleotide residues -197 to -42 in its promoter. This region of the skeletal actin promoter contains three imperfect repeats of a CArG sequence motif that has been d

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20

Schwartzentruber, Jeremy Andrew. "Using molecular QTLs to identify cell types and causal variants for complex traits." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/271308.

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Genetic associations have been discovered for many human complex traits, and yet for most associated loci the causal variants and molecular mechanisms remain unknown. Studies mapping quantitative trait loci (QTLs) for molecular phenotypes, such as gene expression, RNA splicing, and chromatin accessibility, provide rich data that can link variant effects in specific cell types with complex traits. These genetic effects can also now be modeled in vitro by differentiating human induced pluripotent stem cells (iPSCs) into specific cell types, including inaccessible cell types such as those of the

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21

Dicker, Alison Jane. "Comparative gene expression studies of anthelmintic resistance in the parasitic nematode, Teladorsagia circumcincta." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2223/.

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Anthelmintic resistance in parasitic nematodes of small ruminants is widespread and, in some parts of the world, threatens the sustainability of sheep production. The mechanisms whereby parasitic nematodes become resistant to anthelmintics, particularly ivermectin, remain to be determined. The majority of studies to date have investigated target site mutations; relatively little attention has been paid to the role of gene expression changes. The present study focused on Teladorsagia circumcincta; the predominant parasitic gastrointestinal nematode species in the UK and the predominant resistan

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22

Richardson, Jill Caroline. "Characterisation and expression studies of a Xenopus laevis rel homologue." Thesis, University of Warwick, 1991. http://wrap.warwick.ac.uk/109192/.

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Homologues of developmentally important regulatory genes from other species have been found to be expressed in early amphibian development. The Drosophila dorso-ventral polarity .gene, dorsal, is involved in the formation of ventral structures and dorsal- mutants arise from a default state where only dorsal structures are formed. A Xenopus homologue of dorsal may play a crucial role in interpreting some of the earliest embryonic signals.

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23

Coelho, Caroline de Jesus. "TOLERÂNCIA AO ALUMÍNIO EM MILHO TROPICAL: HERANÇA GENÉTICA, MAPEAMENTO DE QTLs E EXPRESSÃO GÊNICA." UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2015. http://tede2.uepg.br/jspui/handle/prefix/2278.

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Made available in DSpace on 2017-07-25T19:30:53Z (GMT). No. of bitstreams: 1 Caroline Coelho D.pdf: 2827635 bytes, checksum: c705ec3ee73baeecb572d551dae9bae8 (MD5) Previous issue date: 2015-12-22<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The objectives of this work were to determine the genetic inheritance, map QTL Al tolerance and quantify the differential gene expression of Al tolerance genes in tropical origin maize. To determine the genetic control of Al tolerance were evaluated diallel crosses between contrasting genotypes in the hybrid maize germplasm and maize

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24

Lima, Rômulo Pedro Macêdo. "Mapeamento de QTLs e eQTLs relacionados à resistência à Phytophthora parasitica (agente causador da gomose dos citros) em citrandarins." Botucatu, 2016. http://hdl.handle.net/11449/144697.

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Orientador: Marcos Antonio Machado<br>Resumo: Phytophthora nicotianae Breda de Haan (Phytophthora parasitica Dastur) e Phytophthora citrophthora (Smith & Smith), agentes causadores da gomose e podridão radicular, têm trazido graves danos em viveiros e pomares de citros no mundo inteiro. O Centro de Citricultura Sylvio Moreira/IAC vem realizando um amplo programa de melhoramento genético de citros via cruzamentos dirigidos com relação ao patossistema Phytophthora-citros, em que já foram verificadas diferenças no nível de resistência na progênie do cruzamento entre tangerina Sunki (Citrus sunki)

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25

Subramanian, Shanmugam Suresh Kannan. "Genetic regulation of adult hippocampal neurogenesis: A Systems genetics approach using BXD recombinant inbred mouse strains." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-88637.

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Adult hippocampal neurogenesis is regulated at various levels and by various factors. Genetic influence is an important key determinant of adult neurogenesis and exerts its effects at all levels. In vivo studies have suggested that adult hippocampal neurogenesis is highly variable and heritable among different laboratory strains of mice. To dissect the genetic effect from other contributing factors, it is necessary to study adult neurogenesis under highly controlled environment conditions. We extracted adult hippocampal precursor cells (AHPCs) from 20 strains of the BXD set of recombinant inbr

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26

Ouni, Meriem. "Relation entre la méthylation des promoteurs du gène IGF1 et les variations de la croissance des enfants." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T015/document.

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A l'interface de la génétique et de l'environnement, l'épigénétique contribue à la diversité phénotypique. Déterminer l'impact de la variation épigénétique sur les caractères quantitatifs (QT) est un nouveau défi. La croissance staturale fournit l’opportunité d’étudier la variabilité de plusieurs traits phénotypiques liés entre eux : des QT cliniques (la taille, l’accélération de la vitesse de croissance en réponse à l'hormone de croissance, GH) et des QT biologiques tels que la concentration d’IGF1 et la réponse de cette concentration à la GH. L’ « Insulin-like Growth Factor 1 » (IGF1) contrô

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27

Duarte, Christine Woods. "A new method for genetic network reconstruction in expression QTL data sets." 2009. http://www.lib.ncsu.edu/theses/available/etd-08172009-225656/unrestricted/etd.pdf.

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28

Chan, Eva King-Fan Biotechnology &amp Biomolecular Science UNSW. "The influence of genetic variation in gene expression." 2007. http://handle.unsw.edu.au/1959.4/40650.

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Variations in gene expression have long been hypothesised to be the major cause of individual differences. An initial focus of this research thesis is to elucidate the genetic regulatory architecture of gene expression. Expression quantitative trait locus (eQTL) mapping analyses have been performed on expression levels of over 22,000 mRNAs from three tissues of a panel of recombinant inbred mice. These analyses are "single-locus" where "linkage" (i.e. significant correlation) between an expression trait and a putative eQTL is considered independently of other loci. Major conclusions from these

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29

Fang, Yu-Fu, and 方昱富. "QTL Mapping of Total Pollen Number and Pollen Viability and Expression Profiling Analysis under Moderate Heat Stress in Tomato." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/yfshz8.

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碩士<br>國立臺灣大學<br>農藝學研究所<br>106<br>High temperature reduces the fruit set rate of tomato, so does the yield. The total pollen number and the pollen viability were recognized as two major factors involving in the reduction of the fruit set rate. In this study, we measured these two traits of heat-sensitive variety CA4, heat-tolerant variety CLN1621N and their offspring population, 78 F7 recombinant inbred lines (RIL), under 30/25 °C day/night temperature. The results showed these two traits were highly correlated to the light intensity and their broad-sense heritability were from 0.3 to 0.6. In o

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Chartrand, Étienne. "Expression et purification de l'hélice transmembranaire S5 du canal potassique hERG et étude par RMN du rôle du segment extracellulaire ILE583-TYR597 dans le syndrome du long QT." Mémoire, 2010. http://www.archipel.uqam.ca/3369/1/M11453.pdf.

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Le syndrome du QT long (SQTL) est une anomalie du coeur caractérisée par une prolongation de l'intervalle de repolarisation entre les ondes Q et T sur l'électrocardiogramme. Ce syndrome pouvant provoquer de l'arythmie et même la mort peut être causé par des mutations génétiques, ou par la prise de certains médicaments. Plusieurs médicaments vendus sous ordonnance qui induisaient le syndrome du QT long ont été retirés du marché au cours de la dernière décennie et plusieurs autres ont échoué les tests de contrôle avant même leur sortie en pharmacie. La plupart de ces médicaments provoquent le SQ

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