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Journal articles on the topic 'Extended-release tablet development and manufacturing'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chandra, Prakash Sunuwar* Meenakshi Kandwal Shivanand Patil. "A Review on Formulation and Evaluation of Mirabegron Extended-Release Tablets." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4859–65. https://doi.org/10.5281/zenodo.15547921.

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A type of modified-release dosage form known as an extended-release (ER) tablet is designed to release the active pharmaceutical ingredient (API) gradually over a long period of time. The human body metabolizes and excretes drugs at different rates. Fast drug absorption may result in peak plasma concentrations that could be harmful, whereas fast clearance in conventional formulations causes subtherapeutic levels that necessitate frequent dose. Extended-release formulations get around these issues and ensure a long-lasting therapeutic effect by modifying the kinetics of medicine release. This s

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2

Chandan, Singh* Dr. Rita Saini and Dr. Shivanand Patil. "A Process Development and Validation of Mirabegron Extended Release 25 Mg and Silodosin 8mg Bilayer Tablet." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 634–43. https://doi.org/10.5281/zenodo.15593321.

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Mirabegron & silodosin, is used often in combination as bilayer tablets, are primarily used to treat the symptoms of overactive bladder (OAB) & benign prostatic hyperplasia (BPH). Mirabegron drug helps to relax bladder muscles by increasing urine storage capacity and reduction in urine urgency. The drug Silodosin helps to relax the muscles in the prostate and bladder neck by improving urinary flow and reducing BPH-related symptoms.  The aim of the research study is to process validation (PV) of the formulation development of bilayer tablet of Mirabegron & silodosin drug. 

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3

Chandan, Singh* Rita Saini Shivanand Patil. "A Review of Bilayer Tablet Technology Immediate and Extended-Release Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4491–503. https://doi.org/10.5281/zenodo.15534239.

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Compared to monotherapy (traditional dosage forms), combination therapy is more common and has several benefits.  The best and most recent example of mixed dose formulation is bilayer tablet technology. The pharmaceutical industry has seen a rise in single-dose formulation that combines 2 or 3 molecules within the tablets. By lowering the number of dosages and increasing the bioavailability of dosage forms, it is well known for encouraging patient convenience and compliance.  Innovative variations of traditional oral drug delivery technologies are bilayer or multilayer tablets. The o

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Alshetaili, Abdullah, Bjad K. Almutairy, Sultan M. Alshehri, and Michael A. Repka. "Development and Characterization of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology." Pharmaceutics 13, no. 2 (2021): 213. http://dx.doi.org/10.3390/pharmaceutics13020213.

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The aim of this work was to develop the sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique via the rational screening of hydrophobic carriers. Hydrophobic carriers with different physicochemical properties such as pH-independent swellability, low-permeability (Eudragit® RS PO (E-RS)), pH-independent non-swellability (ethyl cellulose N7 (EC-N7)), and the presence of lipids (Compritol® 888 ATO (C-888)) with or without pore-forming agents were used to achieve the sustained release profile of DH. Mannitol (MNT) was chosen as the tem

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5

Gangurde, Gayatri* Dhum Manohar Gavali Prashant Sonawane Mitesh. "Review on Bilayer Tablets." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1192–203. https://doi.org/10.5281/zenodo.15019244.

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Bi-layer tablets are essential for developing both immediate and modified drug delivery systems for various diseases. They facilitate controlled medication release, representing a significant advancement in Controlled Drug Delivery Systems (CDDS) and improving the effectiveness of medication delivery. Over the past 30 years, the complexity and costs of introducing new drugs have increased, leading to greater focus on sustained or controlled release systems. Bi-layer tablets enable precise delivery of medications with predetermined release profiles, preventing chemical incompatibilities between

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Prof., Madhuri T. Deshmukh Ganesh Deokate *. Prof. R.V. Shete. "A REVIEW ON BILAYER TECHNOLOGY." Journal of Pharma Research 8, no. 3 (2019): 81–87. https://doi.org/10.5281/zenodo.2620324.

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<strong><em>ABSTRACT</em></strong> <strong><em>O</em></strong><em>ver the past 30 years, the expenses and complications involved in marketing new drug entities have increased with concomitant recognition of therapeutic advantages of controlled drug delivery. Now a days greater attention has been focused on development of controlled & immediate release drug delivery systems. Bi-layer tablet is suitable for sequential release of two drugs in combination and also for sustained release of tablet in which one layer is for immediate release as loading dose and second layer is maintenance dose. S

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Coutinho, Ana Luisa, Asmita Adhikari, and James Polli. "10122 Development of an In Vitro in Vivo Correlation of Itraconazole Spray-Dried Dispersion Tablets." Journal of Clinical and Translational Science 5, s1 (2021): 96–97. http://dx.doi.org/10.1017/cts.2021.649.

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ABSTRACT IMPACT: As the number of poorly water-soluble drugs in development increases, our research will expand on the science behind improving drug solubility and absorption and ensuring that promising poorly-water solubility drugs do not fail drug development. OBJECTIVES/GOALS: Spray-dried dispersion (SDD) tablet formulation is an approach to increase oral drug solubility and absorption. Methods to predict SDD performance in humans are poorly developed. We aim to develop an in vivo in vitro correlation (IVIVC) between in vitro dissolution and in vivo absorption of itraconazole SDD tablets. M

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K, Kulkarni, and Deokar G. "From Challenges to Advancement for Bilayer Tablet Technology as Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1676–82. https://doi.org/10.25258/ijddt.14.4.64.

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Bilayer tablet technology is in focus because it advantageous for combination therapy, for combining two different release profile and it gives patent novelty to existing dosage. Hence its advantages, challenges and applications need to be discuss. The objective of preparing a review article on bilayer tablets is multifaceted, aiming to cover challenges at formulation development to scaleup and opportunity for new product development by integrating it bilayer tablet technology with other formulation technology. With reference to all the electronic data it was found that bilayer tablets face ma

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9

Jain, Priyanshi, ,. Ekta, R. S. Kushwaha, and Azaz Khan. "Formulation and Evaluation of Sustained Release Matrix Tablets of Isoxsuprine Hydrochloride by Direct Compression Method." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 80–85. http://dx.doi.org/10.22270/jddt.v9i3-s.2797.

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A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. Isoxsuprine hydrochloride is structurally a novel vasodilator. The short biological half-life (5±2 hr) and the fast clearance make the drug, a suitable candidate for the development of modified release formulation. A novel oral controlled delivery system for isoxsuprine hydrochloride was developed and optimized. Matrix tablets of isoxsuprine hydrochloride were prepared by using hydroxypropylmethylcellulose (HPMC K15

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10

Sadhana, Shahi, B. Barkate Manoj, A. Shete Nikita, and N. Bobade Manjari. "A Review on Multi-layered Tablets: A way to control the drug release." AMERICAN JOURNAL OF PHARMACY AND HEALTH RESEARCH 11, no. 01 (2023): 1–18. https://doi.org/10.5281/zenodo.7807820.

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ABSTRACT Due to necessities their affordable manufacturing costs and simplicity of administration, especially in controlled-release applications, tablet dosage forms have traditionally been chosen over other formulations for oral medication delivery. Over monotherapy, combination therapy has a number of benefits. The pharmaceutical industry has grown more interested in recent years in creating dosage forms (monolithic, bilayer, or multi-layered tablets) that combine two or more Active Pharmaceutical Ingredients (API), improving patient convenience and compliance. The active pharmaceutical ingr

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Sadhu, Venkateswara Rao, Priyanka Bopparaju, and Padmalatha Kantamneni. "Bilayer tablet technology: A novel approach." GSC Biological and Pharmaceutical Sciences 7, no. 2 (2019): 022–28. https://doi.org/10.5281/zenodo.4286145.

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Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second lay

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12

S.G.Gavande, R.O.Sonwane A.D.Pichkewar S.S.Dorik. "REVIEW ON IMMEDIATE RELEASE DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 04 (2019): 8509–18. https://doi.org/10.5281/zenodo.2652693.

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<em>Most popular immediate release dosage forms such as tablet, capsule and pellet.</em><em> Because of its convenience of self-administration, and simple to the manufacturing. The type of dosage from is some advantages such as improved stability of formulation. Improved bioavablity of Product. Rapid onset action and cost effective as compare to other dosage formulation. They disintegrant are selected as type of dosage and physical characteristics of drugs. </em><em>The basic approach used in development tablets, capsule and pellet as the use of some excipient like superdisintegrants, Bulking

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13

Bhowmick, Argha, Arup Manna, Sanat Kumar Mandal, et al. "Formulation Development, Evaluation and Statistical Optimization of the Release Rate of Oral Sustained Release Matrix Tablet of Aceclofena." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 4 (2022): 6026–33. http://dx.doi.org/10.37285/ijpsn.2022.15.4.2.

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Aim: This work aimed to develop a sustained released hydrophilic matrix tablet of Aceclofenac for better therapeutic action.  Background: Conventional dosage form didn't provide the desired level of drug release. Even many-marketed sustained-release tablets didn't always meet the satisfactory level of drug release. It was a challenging job for pharmaceutical scientists to develop a well-sustained release formulation. Keeping this perspective in mind a robust sustained release formulation was designed, developed and optimized with nontoxic, inert viscoelastic, semisynthetic polymers which

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14

Vijay, Kumar R.*1 Vikram T. Choudhary2 Gururaj S. Kulkarni3 Padmaa Paarak4. "Advancements In Sintered Tablet Technology : A Comprehensive Review." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 811–24. https://doi.org/10.5281/zenodo.13770632.

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The pharmaceutical industry has found that sintering tablets is a potential method for creating solid dosage forms with better drug delivery properties. An extensive summary of the most current developments in sintered tablet technology is given in this article. The study starts out by explaining the basics of sintering with an emphasis on the production procedures, formulation techniques, a variety of sintering techniques are covered, including traditional thermal sintering and cutting-edge approaches like microwave and laser sintering. Their benefits and drawbacks in the production of tablet

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15

Patil, Nilesh Sureshrao, and Kishor Salunkhe. "FORMULATION DEVELOPMENT AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLET OF ATORVASTATIN USING STATISTICAL DESIGN (JMP SOFTWARE)." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 19–25. http://dx.doi.org/10.22270/jddt.v9i4-a.3284.

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More complications and cost of promoting of imaginative drugs are more prominent consideration to the improvement of controlled release (CR) drug delivery systems. Sustained release or controlled release drug delivery system helps to reduced toxicity of drug and more patient compliant drug delivery system. The aim of this study is to have efficient means of manufacturirng of Gastro retentive floating tablet of Atorvastatin Calcium. Atorvastatin is used in the treatment of hyperlipidaemia. Oral bioavailability of atorvastatin calcium is less than 12% due to instability and in complete absorptio

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16

Amit, Pareek, and Kumar Gupta Mukesh. "An Overview of The Bilayer Tablet." International Journal of Current Pharmaceutical Review and Research 14, no. 04 (2022): 106–10. https://doi.org/10.5281/zenodo.12657682.

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In the history of the development of the controlled release formulation, the introductionof bilayer tablets marked the beginning of a new age. This innovation, in alongside otherfactors, has made it possible to successfully provide medications to the body. Through the useof physical separation, such as bilayer tablets, it is possible to prevent chemicalincompatibilities between API. Additionally, new pharmaceutical release patterns may bedeveloped. This article provides an overview of the most recent developments in thetechnology behind bilayer tablets, with a primary emphasis on the most sign

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Amit, Pareek, and Kumar Gupta Mukesh. "An Overview of The Bilayer Tablet." International Journal of Current Pharmaceutical Review and Research 14, no. 4 (2022): 106–10. https://doi.org/10.5281/zenodo.7612899.

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In the history of the development of the controlled release formulation, the introduction of bilayer tablets marked the beginning of a new age. This innovation, in alongside other factors, has made it possible to successfully provide medications to the body. Through the use of physical separation, such as bilayer tablets, it is possible to prevent chemical incompatibilities between API. Additionally, new pharmaceutical release patterns may be developed. This article provides an overview of the most recent developments in the technology behind bilayer tablets, with a primary emph

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18

Padhan1, Ashutosh. "Bi-Layer Tablets for Controlled Release Drug Delivery." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 09, no. 02 (2025): 1–9. https://doi.org/10.55041/ijsrem41526.

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Bilayer tablets has the potential for successful combination therapy as novel drug delivery system. Bilayer tablets are modified release system in which one layer serves as loading dose and the other layer serves as maintenance dose to enhance the bioavailability or to avoid the interaction between the incompatible substances by separating them physically. Several The development of bi-layer tablets for a variety of reasons like patent extension, therapeutic, and marketing purposes. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. The

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19

Kute, Vaibhav Ghansham, and Manmeet Singh. ""Development And Assessment of Immediate Release Nitrofurantoin Tablet and Sustained Release Trimethoprim Tablet: Formulation, Characterization and Comparative Evaluation"." International Journal of Membrane Science and Technology 10, no. 5 (2023): 867–77. http://dx.doi.org/10.15379/ijmst.v10i5.3581.

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The research includes an examination of material properties, an investigation into the compatibility of the drug and excipients, the development of analytical techniques, and the determination of tablet production methods for immediate and sustained release layers. The methodology for material characterization encompassed the analysis of the pharmaceuticals' solubility in various aqueous solutions and buffers. The evaluation of the compatibility between excipients and medications was conducted utilizing FT-IR spectroscopy. Furthermore, calibration curves were devised by the research team for N

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Kailash Sahu, Vimlendu Kumar, Pooja Lodhi, and Bhaskar Kumar Gupta. "Different types of pharmaceutical tablets used for treatment of diseases." GSC Biological and Pharmaceutical Sciences 21, no. 2 (2022): 001–11. http://dx.doi.org/10.30574/gscbps.2022.21.2.0398.

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In modern age of revolution and development in drug delivery for better clinical effects conventional dosages form have still a strong grip and most popular in all kinds of medicinal preparation intended for oral use. To satisfy the need of growing market tablets dosages form have incorporated modernization in producing and some advanced tablet types. Modified release tablet formulations including, layered tablets such as In +--lay tablet, Bi-layered tablet, Medicated chewing gum, Tablet tarts, Pastilles, Lollipop, Tablet inserts, Clinicaps, Caplets, Child ecstasy tablet and Tablet in tablet a

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Kailash, Sahu, Kumar Vimlendu, Lodhi Pooja, and Kumar Gupta Bhaskar. "Different types of pharmaceutical tablets used for treatment of diseases." GSC Biological and Pharmaceutical Sciences 21, no. 2 (2022): 001–11. https://doi.org/10.5281/zenodo.7649131.

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In modern age of revolution and development in drug delivery for better clinical effects conventional dosages form have still a strong grip and most popular in all kinds of medicinal preparation intended for oral use. To satisfy the need of growing market tablets dosages form have incorporated modernization in producing and some advanced tablet types. Modified release tablet formulations including, layered tablets such as In +--lay tablet, Bi-layered tablet, Medicated chewing gum, Tablet tarts, Pastilles, Lollipop, Tablet inserts, Clinicaps, Caplets, Child ecstasy tablet and Tablet in tablet a

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22

Bhuyar, Sajali R., Manjiri M. Auti, Shubhangi A. Bhise, et al. "Innovations and advancements in floating tablet drug delivery systems: a comprehensive review." Pharmacy & Pharmacology International Journal 12, no. 5 (2024): 195–200. https://doi.org/10.15406/ppij.2024.12.00452.

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Floating tablets, also known as gastro retentive drug delivery systems (GRDDS), are innovative formulations designed to prolong the retention of drugs in the gastrointestinal tract, particularly the stomach. This approach is highly beneficial for medications with a narrow absorption window in the upper GI tract, requiring extended action or optimal absorption in a specific pH range. The floating mechanism helps improve bioavailability, therapeutic efficacy, and offers controlled drug release, reducing dosage frequency. The formulation of floating tablets typically involves hydrophilic polymers

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23

Kim, Hyeon-A., and Joo-Eun Kim. "Development of Nafamostat Mesylate Immediate-Release Tablet by Drug Repositioning Using Quality-by-Design Approach." Pharmaceutics 14, no. 6 (2022): 1219. http://dx.doi.org/10.3390/pharmaceutics14061219.

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We aimed to develop nafamostat mesylate immediate-release tablets for the treatment of COVID-19 through drug repositioning studies of nafamostat mesylate injection. Nafamostat mesylate is a serine protease inhibitor known to inhibit the activity of the transmembrane protease, serine 2 enzyme that affects the penetration of the COVID-19 virus, thereby preventing the binding of the angiotensin-converting enzyme 2 receptor in vivo and the spike protein of the COVID-19 virus. The formulation was selected through a stability study after manufacturing by a wet granulation process and a direct tablet

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Mandal, Raj Kumar, Paarth Saini, Rahul Pal, Prachi Pandey, and Anshita Dubey. "Coating Tablets, Compositions, Recent Advancement and Current Status: A Comprehensive Review." Journal of Drug Delivery and Therapeutics 14, no. 10 (2024): 182–95. http://dx.doi.org/10.22270/jddt.v14i10.6809.

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Conventional Tablets are solid oral dosage forms that contain an active pharmaceutical ingredient (API) along with excipients. These tablets are typically prepared through direct compression, wet granulation, or dry granulation. They are designed to disintegrate and release the API in a controlled or immediate manner, depending on the formulation. Tablet coating is a vital process in pharmaceutical technology, designed to improve the therapeutic efficacy, patient compliance, and stability of oral dosage forms. This comprehensive review explores the key aspects of tablet coating, including the

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Majeed, Saad M., Mohammed K. Al-Shaheen, Radhwan Nidal Al-Zidan, and Sameer M. Mahmood. "Multiple Unite Pellet Systems (MUPS) as Drug Delivery model." Journal of Drug Delivery and Therapeutics 10, no. 6 (2020): 231–35. http://dx.doi.org/10.22270/jddt.v10i6.4389.

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Multiparticulate drug delivery systems are mainly oral dosage form, consist of small discrete units that exhibit different characteristics especially in release pattern and drug bioavailability. These systems are represented by granules, pellets, microspheres, microcapsules, and minitablets. Pellets offer high flexibility in the design, formulation, and development of oral dosage forms such as sachet, suspension, capsule, and tablet. Multiparticulate tablets manufactured by compaction of multiple unite pellets is one of the latest and, yet, challenging technologies. Multiparticulate tablets co

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Tuyen, Nguyen Thi Linh, Le Quan Nghiem, Nguyen Duc Tuan, and Phuoc Huu Le. "Development of a Scalable Process of Film-Coated bi-Layer Tablet Containing Sustained-Release Metoprolol Succinate and Immediate-Release Amlodipine Besylate." Pharmaceutics 13, no. 11 (2021): 1797. http://dx.doi.org/10.3390/pharmaceutics13111797.

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The development of new drugs that combine active ingredients for the treatment hypertension is critically essential owing to its offering advantages for both patients and manufacturers. In this study, for the first time, detailed development of a scalable process of film-coated bi-layer tablets containing sustained-release metoprolol succinate and immediate-release amlodipine besylate in a batch size of 10,000 tablets is reported. The processing parameters of the manufacturing process during dry mixing-, drying-, dry mixing- completion stages were systematically investigated, and the evaluatio

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Algahtani, Mohammed S., Abdul Aleem Mohammed, Javed Ahmad, M. M. Abdullah, and Ehab Saleh. "3D Printing of Dapagliflozin Containing Self-Nanoemulsifying Tablets: Formulation Design and In Vitro Characterization." Pharmaceutics 13, no. 7 (2021): 993. http://dx.doi.org/10.3390/pharmaceutics13070993.

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The 3D printing techniques have been explored extensively in recent years for pharmaceutical manufacturing and drug delivery applications. The current investigation aims to explore 3D printing for the design and development of a nanomedicine-based oral solid dosage form of a poorly water-soluble drug. A self-nanoemulsifying tablet formulation of dapagliflozin propanediol monohydrate was developed utilizing the semisolid pressure-assisted microsyringe (PAM) extrusion-based 3D printing technique. The developed formulation system consists of two major components (liquid and solid phase), which in

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Santosh, Kitawat, Bharkatiya Meenakshi, and Dashora Nipun. "Formulation Development and Evaluation of Inlay Tablets of Anti-Inflammatory Drug." Pharmaceutical and Chemical Journal 6, no. 5 (2019): 18–27. https://doi.org/10.5281/zenodo.13942042.

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Tablets may be defined as solid pharmaceutical dosage forms containing drug substances with or without suitable diluents and prepared either by compression or molding methods. They have been in widespread use since the latter part of the 19<sup>th</sup> century and their popularity continues. In the present study inlay tablets of an anti-inflammatory drug was formulated and evaluated. The tablet is most widely used dosage form because of its ease of administration, compactness and ease of manufacturing. The aim of study is to formulate combination of an anti-inflammatory agent and proteolytic

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Sisodiya, Mayuri, and Ravindranath Saudagar. "SOLUBILITY ENHANCEMENT, FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLET OF ANTIHYPERTENSIVE DRUG TADALAFIL." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 294–302. http://dx.doi.org/10.22270/jddt.v8i5.1872.

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The objective of the study was to enhance the solubility and dissolution rate of Tadalafil using hydrophilic carriers such as PVP K-30, Poloxamer 188, Sodium starch glycolate and compatibility study of Tadalafil with different polymers by FTIR. Characterization of solid dispersion-FTIR, DSC and phase solubility analysis was study to improve the oral bioavailability. Formulation and evaluation of immediate release tablets prepare from solubility enhanced Tadalafil. Among the various approaches Solvent evaporation has gained good acceptance in recent years in the industry for enhancing the solub

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Mehetre, Gautam D., and A. Dubey. "Formulation-Development and In-Vitro-In Vivo Evaluation of Gastroretentive Floating Tablet Incorporating Clarithromycin." Journal of Drug Delivery and Therapeutics 9, no. 5 (2019): 67–81. http://dx.doi.org/10.22270/jddt.v9i5.3559.

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The objective of the work is to summarize the applicability, manufacturing possibilities, excipients and the types of floating drug delivery systems and to optimize a floating, mucoadhesive system using Clarithromycin as the drug aiming at the eradication of Helicobacter pylori having desired floating and drug release properties based on preliminary excipient examination. Direct compressed (DC) tablet was chosen as dosage form being a cost-effective technology for pharmaceutical industry requiring fewer procedures. Before the implementation of the pharmaceutical technological aims, analysis of

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Kale, Megha K. Wagh Snehal A. Walunj Ankita A. Dhage Shubhangi S. Awari Monika S. Bhalekar S. M. Lamkhade. G. J. "Recent Advances In Oral Solid Dosage Form Formulation And Development." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 1075–91. https://doi.org/10.5281/zenodo.13955626.

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The most sensible, safest, and natural way to take medication is through the mouth. An overview of the most recent materials and technologies utilized to address issues with patient compliance, pharmaceutical release, absorption, and overall efficacy will be given in this article. Because of their superior patient compliance, portability, stability, and convenience of handling, tablets are the most often used solid oral dose form. Over time, tableting technology has made considerable advancements. This work seeks to shed light on advancements in tablet excipients, production procedures, analyt

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D.G., Umalkar, P. Awate Gajanan, J. Bidkar S., and Dama G.Y. "Formulation and Evaluation of Ondansetron HCL Mouth Dissolving Tablet." Journal of Pharma and Drug Regulatory Affairs (e-ISSN: 2582-3043) 2, no. 1 (2020): 31–36. https://doi.org/10.5281/zenodo.3629106.

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<em>Recent development in mouth dissolving tablet of Ondansetron hydrochloride were designed with a view to enhance patient compliance, reduce manufacturing cost and manufacturing time by using co-processed excipient i.e. DiCOM DC MD with direct compression method. Prepared Batches of tablet were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dissolution time. Based on in vitro time, prepare formulation were tested for in vitro drug release pattern (in pH7.4phosphate buffer).</em><em> </em>

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Yazdi, Zahra Rezaie, Mark C. Leaper, and Danish J. Malik. "The Development of Oral Solid Dosage Forms Using the Direct-Compression Tableting of Spray-Dried Bacteriophages Suitable for Targeted Delivery and Controlled Release." Processes 11, no. 11 (2023): 3146. http://dx.doi.org/10.3390/pr11113146.

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This study addresses the challenge of developing a cheap, patient-friendly alternative to antibiotics using bacteriophages for gastrointestinal applications. It explores the feasibility of manufacturing an enteric solid dosage form containing a salmonella-specific Myoviridae phage, Felix O1, encapsulated in spray-dried trehalose/Eudragit microparticles. The spray-dried powder was further formulated by combining the spray-dried microparticles with magnesium stearate to facilitate the fabrication of tablets using direct compression. The paper presents a comprehensive evaluation of the tablets wi

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Pawar, Prajakta Arun, Vivek Ranjan Sinha, and Ashok Kumar Yadav. "Compatibility Study of Fenofibrate with Some Common Excipients and Their Effect on Solid Doge Formulation Development." Journal of Modern Biology and Drug Discovery 3 (July 4, 2024): 4. http://dx.doi.org/10.53964/jmbdd.2024004.

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Objective: Through fenofibrate (Fen) and excipient compatibility assessments and the development of Fen pellets, the current study aims to discover suitable excipients to improve performance and stability of oral solid formulations. Methods: Analytical instruments [Differential Scanning Calorimetry – Q20, TA Instruments, Fourier Transform Infrared Spectroscopy Spectrum RX 1, Bruker Advance Neo 500MHz Nuclear Magnetic Resonance Spectrometer, and Thin Layer Chromatography)] were used to characterize Fen and to study the compatibility. Excipients and Fen were obtained from Loba chemie and Biocon,

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M. G., Mowafaq. "Development and evaluation of or dispersible tablet of Propranolol Hydrochloride by sublimation technique." Al Mustansiriyah Journal of Pharmaceutical Sciences 13, no. 2 (2013): 65–72. http://dx.doi.org/10.32947/ajps.v13i2.202.

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Propranolol Hydrochloride (PHCl) is a synthetic beta adrenergic receptor blockingagent used widely in the treatment of angina pectoris, cardiac arrhythmias and hypertension.The purpose of this study was to develop PHCl orodispersible tablet of fast disintegration inmouth with high mechanical strength to withstand handling during manufacturing and patientuse.Sublimation technique was used to prepare the orodispersible tablets of PHCl using foursubliming agents; camphor, thymol, ammonium bicarbonate and menthol by directcompression method in presence of 2.5%w/w crospovidone as superdisintegrant.

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V.PavanKumar*, and V.Saikishore. "DESIGN AND DEVELOPMENT OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISSOLVING TABLETS FOR ENHANCING THE SOLUBILITY OF IBUPROFEN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 08 (2018): 8230–36. https://doi.org/10.5281/zenodo.1407516.

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The main focus of this work was to enhance the solubility and bioavailability of Ibuprofen by using spherical crystallization technique. This technique was developed by Kawashima and their coworkers in 1986, by which crystallization and agglomeration can be carried out at once in a single step to convert crystals straight into compressed spherical form. Spherical agglomerates were obtained by the quasi-emulsion solvent diffusion method, in which ibuprofen was dissolved in the mixture of methanol (good solvent), dichloromethane (bridging liquid) and poor solvent (distilled water containing poly

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Yoo, Okhee, Edith Tang, Md Lokman Hossain, et al. "The Development of a Chocolate-Based Chewable Tablet of Prednisolone—Enhancing the Palatability of Steroids for Pediatric Use." Pharmaceutics 16, no. 8 (2024): 1099. http://dx.doi.org/10.3390/pharmaceutics16081099.

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Oral liquid prednisolone medications have poor acceptance among paediatric patients due to ineffective masking of the bitterness taste of prednisolone. This study aimed to develop a child-friendly prednisolone tablet using a patented chewable chocolate-based delivery system (CDS) previously applied successfully to mask the bitterness tastes of midazolam and tramadol. Prednisolone sodium phosphate (PSP) and prednisolone base (PB) CDS tablets were prepared, and the manufacturing process was optimised using a design of experiments (DoE) approach. Stability was assessed by quantifying residual dru

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Ahmed, Tarek A., Hanadi A. Alotaibi, Waleed S. Alharbi, Martin K. Safo, and Khalid M. El-Say. "Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization." Pharmaceuticals 15, no. 1 (2022): 68. http://dx.doi.org/10.3390/ph15010068.

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Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous solubility. The aim of this study was to develop glimepiride tablets using three different manufacturing techniques, as well as to study their quality attributes and pharmacokinetics behavior. Black seed oil based self-nanoemulsifying drug delivery system (SNEDDS) formulation was developed and characterized. Glimepiride liquisolid and directly compressed tablets were prepared and their pre-compression and post-compression characteristics were evaluated. Semi-solid pastes loaded with SN

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Afkhami, Seyedebrahim, Meisam Abdi, and Reza Baserinia. "Effect of Geometry on the Dissolution Behaviour of Complex Additively Manufactured Tablets." Journal of Manufacturing and Materials Processing 9, no. 1 (2025): 11. https://doi.org/10.3390/jmmp9010011.

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Additive manufacturing (AM) processes, such as fused deposition modelling (FDM), have emerged as transformative technologies in pharmaceutical manufacturing, enabling the production of drug delivery systems with complex and customised geometries. These advancements provide precise control over drug release profiles and facilitate the development of patient-specific medicines. This study investigates the dissolution behaviour of AM-fabricated tablets made from polyvinyl alcohol (PVA), a hydrophilic and biocompatible polymer widely used in drug delivery systems. The influence of the initial mass

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Stanojević, Gordana, Ivana Adamov, Snežana Mugoša, Veselinka Vukićević, and Svetlana Ibrić. "Selective Laser Sintering of Atomoxetine Tablets: An Innovative Approach for Small-Scale, Personalized Production." Pharmaceutics 17, no. 6 (2025): 794. https://doi.org/10.3390/pharmaceutics17060794.

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Background/Objectives: The growing interest in personalized medicine has accelerated the exploration of three-dimensional (3D) printing technologies in pharmaceutical applications. This study investigates the potential of selective laser sintering (SLS) as a flexible, small-scale manufacturing method for atomoxetine tablets tailored for individualized therapy, comparing it with conventional direct compression. Methods: Atomoxetine tablets were produced using SLS 3D printing with varying laser scanning speeds and compared to tablets made via a compaction simulator. Formulations were based on hy

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Arti, Parmar* Akanksha jagwani Toshiba Khanam Narendra Gehalot Vikas Jain. "COMPREHENSIVE REVIEW ON FORMULATION AND MANUFACTURING TECHNIQUES OF BILAYER TABLETS." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3117–21. https://doi.org/10.5281/zenodo.13316959.

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Bilayer tablets are an inventive and adaptable drug delivery device because they have two layers, each with a unique drug release profile. This review summarises the development, manufacturing processes, formulation strategies, and pharmaceutical uses of bilayer tablets. Carefully choosing formulation ingredients is essential to the effectiveness of these tablets, taking into account medication compatibility as well as the effects of formulation variables on stability and bioavailability. A range of manufacturing approaches are examined, emphasising their scalability and appropriateness for ce

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Niranjan, Abadhesh Kumar, and Alka Singh. "Formulation, Development and Evaluation of Bilayer Floating Tablets of Antihypertensive Drug Bosentan." Journal of Drug Delivery and Therapeutics 11, no. 6 (2021): 167–72. http://dx.doi.org/10.22270/jddt.v11i6.5113.

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Hypertension, or high blood pressure, is a major public health concern around the world because of its large contribution to the global health burden and its function as a major risk factor for a variety of disease processes. Bosentan SR Floating Bilayer Tablets were made with HPMC K4M, HPMC E-15, and HPMC E-15 alone (80%) and in combination with varying percentages of polymer (20&60 percent, 40&40 percent, and 60&20 percent ). The hydrophilic polymer HPMC is used to make three different formulations (M4, M8, and M12) of floating Bosentan SR tablets, each with a viscosity grade of

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Ahmed, Mohd Salman, Nikita Upadhyay, and P. K. Dubey. "A REVIEW ON FAST DISSOLVING TABLET." International Journal of Pharmaceutical Sciences and Medicine 7, no. 5 (2022): 37–47. http://dx.doi.org/10.47760/ijpsm.2022.v07i05.004.

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Fast dissolving tablets (FDTs) emerged as one of the popular and widely accepted dosage forms. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia) resulting many incidences of non-compliance and making the therapy ineffective. Specifically for paediatric patients because of incomplete development of the muscular and nervous system and case of geriatric patients suffering from Parkinson’s disorder. Oral dosage form and oral route are the most preferred administration route for various drugs with limitations like first-p

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Kumar, Pramod, Sanjay Singh, and Brahmeshwar Mishra. "Development and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technology." Acta Pharmaceutica 59, no. 1 (2009): 15–30. http://dx.doi.org/10.2478/v10007-009-0010-2.

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Development and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technologyExtended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was developed and evaluated. Target release profile was selected and different variables were optimized to achieve it. Formulation variables such as the level of swellable polymer, plasticizer and the coat thickness of semipermeable membrane (SPM) were found to markedly affect drug release. TRH release was directly proportional to the levels of plasticizer but inversely proporti

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Mohylyuk, Valentyn, and Dace Bandere. "High-Speed Tableting of High Drug-Loaded Tablets Prepared from Fluid-Bed Granulated Isoniazid." Pharmaceutics 15, no. 4 (2023): 1236. http://dx.doi.org/10.3390/pharmaceutics15041236.

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The aim of this feasibility study was to investigate the possibility of producing industrial-scale relevant, robust, high drug-loaded (90.9%, w/w) 100 mg dose immediate-release tablets of isoniazid and simultaneously meet the biowaiver requirements. With an understanding of the real-life constrictions on formulation scientists during product development for the generic industry, this study was done considering a common set of excipients and manufacturing operations, as well as paying special attention to the industrial-scale high-speed tableting process as one of the most critical manufacturin

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Chen, Xuejun, Shanshan Wang, Jie Wu, et al. "The Application and Challenge of Binder Jet 3D Printing Technology in Pharmaceutical Manufacturing." Pharmaceutics 14, no. 12 (2022): 2589. http://dx.doi.org/10.3390/pharmaceutics14122589.

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Three-dimensional (3D) printing is an additive manufacturing technique that creates objects under computer control. Owing to the rapid advancement of science and technology, 3D printing technology has been widely utilized in processing and manufacturing but rarely used in the pharmaceutical field. The first commercial form of Spritam® immediate-release tablet was approved by FDA in 2015, which promoted the advancement of 3D printing technology in pharmaceutical development. Three-dimensional printing technology is able to meet individual treatment demands with customized size, shape, and relea

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Gawshinde, Arpit Gawshinde. "Formulation, development and evaluation of paracetamol tablet by moisture activated dry granulation (MADG) process." Journal of Pharmaceutical and Biological Sciences 12, no. 1 (2024): 60–67. http://dx.doi.org/10.18231/j.jpbs.2024.010.

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Paracetamol, also known as acetaminophen, is a painkiller that is popular throughout the world because it does not irritate the stomach. Paracetamol was first discovered to have both analgesic and antipyretic properties in the late nineteenth century. The aim of present work was to Formulate, develop and evaluate Paracetamol Tablets by Moisture Activated Dry Granulation (MADG) process to short manufacturing time and process variables as compared with convention process. Colloidal anhydrous silica is used in the formulation to absorb the extra moisture present in the MADG process formulation. A

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Crișan, Andrea Gabriela, Alina Porfire, Sonia Iurian, et al. "Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System." Pharmaceuticals 16, no. 9 (2023): 1321. http://dx.doi.org/10.3390/ph16091321.

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Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence of research efforts directed toward the development of personalized dosage forms. In addition to the customization in terms of shapes, sizes, or delivered drug doses, the modulation of drug release profiles is crucial to ensure the superior efficacy and safety of modern 3D-printed medications compared to those of conventional ones. Our work aims to solidify the groundwork for the preparation of 3D-printed tablets that ensure the sustained release of diclofenac sodium. S

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Pramod, Prakash Ronge* Dr. A.D. Shinde. "A REVIEW ON –FORMULATION AND IN-VITRO EVALUATION OF ORODISPERSIBLE TABLETS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 10991–1000. https://doi.org/10.5281/zenodo.3234069.

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<em>Recent advances in novel drug delivery (NDDS) aims to enhance the safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance.</em><em> Orodispersible tablet is advanced and convenient drug delivery system, now days acquiring the most widely accepted dosage form. The recent advance in NDDS aimed for the development of dosage forms convenient to manufacturing and administration, immediate release and increased bioavailability.</em> <em>Orally disintegrating tablets are solid dosage forms containing drug tha

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Prajapati, Vinitbhai*1 Himanshu Sharma2 Sagar Patra3 Sahilahmad Makarani3 Mahendrakumar Dubey1. "A Contemporary Approach to The Medicate Conveyane Through Orodispersible Tablets." International Journal of Scientific Research and Technology 1, no. 12 (2024): 29–40. https://doi.org/10.5281/zenodo.14285188.

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The development of dosage forms that are easy to manufacture and administer, as well as rapid release and increased bioavailability, have led to new drug delivery systems. To achieve the desired result, drugs must be delivered to the site of action at a speed and concentration that maximizes therapeutic benefits and minimizes side effects. The most popular and efficient way of drug administration is oral. Recently, many medicinal products have been released in the market. The use of lyophilizers and oral tablets or films have expanded treatment options. Both children and adults can benefit fro

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