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Journal articles on the topic 'External peripheral channel'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Bole, Velimir, Miha Dominko, Ada Gustin-Habus, and Janez Prasnikar. "Countries of former yugoslavia: Periphery vs. super-periphery in the great recession and beyond." Ekonomski anali 64, no. 223 (2019): 11–38. http://dx.doi.org/10.2298/eka1923011b.

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The paper deals with the performance of former Yugoslav countries during the Great Recession. It compares the performance of peripheral countries (Slovenia and Croatia) with those of superperipheral countries (Bosnia, the Republic of North Macedonia, Montenegro, and Serbia). The focus of the analysis is the four channels of crisis transmission and amplification: the capital surge as the external channel on the one hand, and the financial accelerator, the banking credit extension, and liquidity as internal channels on the other. While the external channel drove the dynamics of the crisis, the i

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Bell, Damian C., Huan Yao, Renee C. Saenger, John H. Riley, and Steven A. Siegelbaum. "Changes in Local S4 Environment Provide a Voltage-sensing Mechanism for Mammalian Hyperpolarization–activated HCN Channels." Journal of General Physiology 123, no. 1 (2003): 5–20. http://dx.doi.org/10.1085/jgp.200308918.

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The positively charged S4 transmembrane segment of voltage-gated channels is thought to function as the voltage sensor by moving charge through the membrane electric field in response to depolarization. Here we studied S4 movements in the mammalian HCN pacemaker channels. Unlike most voltage-gated channel family members that are activated by depolarization, HCN channels are activated by hyperpolarization. We determined the reactivity of the charged sulfhydryl-modifying reagent, MTSET, with substituted cysteine (Cys) residues along the HCN1 S4 segment. Using an HCN1 channel engineered to be MTS

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Kashlan, Ossama B., and Thomas R. Kleyman. "ENaC structure and function in the wake of a resolved structure of a family member." American Journal of Physiology-Renal Physiology 301, no. 4 (2011): F684—F696. http://dx.doi.org/10.1152/ajprenal.00259.2011.

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Our understanding of epithelial Na+ channel (ENaC) structure and function has been profoundly impacted by the resolved structure of the homologous acid-sensing ion channel 1 (ASIC1). The structure of the extracellular and pore regions provide insight into channel assembly, processing, and the ability of these channels to sense the external environment. The absence of intracellular structures precludes insight into important interactions with intracellular factors that regulate trafficking and function. The primary sequences of ASIC1 and ENaC subunits are well conserved within the regions that

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White, JG. "The secretory pathway of bovine platelets." Blood 69, no. 3 (1987): 878–85. http://dx.doi.org/10.1182/blood.v69.3.878.878.

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Abstract Human platelets contain tortuous channels in their cytoplasm, the surface-connected or open canalicular system (OCS), that communicate directly with the surrounding medium through openings on the surface membrane. Some workers have suggested that the OCS serves as the egress route for products secreted during the release reaction. Others have proposed alternate secretory pathways. Since bovine platelets lack the OCS found in human cells, the present study has examined the secretory mechanism of these cells to see whether it can shed light on the mystery of human platelet secretion. Bo

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White, JG. "The secretory pathway of bovine platelets." Blood 69, no. 3 (1987): 878–85. http://dx.doi.org/10.1182/blood.v69.3.878.bloodjournal693878.

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Human platelets contain tortuous channels in their cytoplasm, the surface-connected or open canalicular system (OCS), that communicate directly with the surrounding medium through openings on the surface membrane. Some workers have suggested that the OCS serves as the egress route for products secreted during the release reaction. Others have proposed alternate secretory pathways. Since bovine platelets lack the OCS found in human cells, the present study has examined the secretory mechanism of these cells to see whether it can shed light on the mystery of human platelet secretion. Bovine plat

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Kralkina, Elena, Polina Nekludova, Aleksander Nikonov, Konstantin Vavilin, Ilya Zadiriev, and Vladimir Tarakanov. "Influence of external parameters on RF inductive discharge plasma characteristics." Plasma Sources Science and Technology 30, no. 11 (2021): 115020. http://dx.doi.org/10.1088/1361-6595/ac331a.

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Abstract Systematic experimental studies of the electron density and temperature, the efficiency of RF power coupling to the RF inductive discharge plasma have been carried out in the pressure range of helium, neon, argon, and krypton 0.1–133 Pa, at an RF generator power of 100–500 W and frequencies of 2, 4 and 13.56 MHz. It is shown that the electron density reaches a maximum, and the temperature reaches a minimum in the pressure range 1.33–13.3 Pa. Taking into account the presence of a parasitic capacitive coupling between the inductor and the plasma, which forms the capacitive channel of RF

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Vaneev, S., D. Miroshnichenko, S. Meleychuk, and V. Baga. "Research of multi-flow and multi-channel flow parts of the vortex expansion machines with the external peripheral channel." IOP Conference Series: Materials Science and Engineering 233 (August 2017): 012020. http://dx.doi.org/10.1088/1757-899x/233/1/012020.

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Mitchell, Josephine W., Ipek Midillioglu, Ethan Schauer, Bei Wang, Chun Han, and Jill Wildonger. "Coordination of Pickpocket ion channel delivery and dendrite growth in Drosophila sensory neurons." PLOS Genetics 19, no. 11 (2023): e1011025. http://dx.doi.org/10.1371/journal.pgen.1011025.

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Sensory neurons enable an organism to perceive external stimuli, which is essential for survival. The sensory capacity of a neuron depends on the elaboration of its dendritic arbor and the localization of sensory ion channels to the dendritic membrane. However, it is not well understood when and how ion channels localize to growing sensory dendrites and whether their delivery is coordinated with growth of the dendritic arbor. We investigated the localization of the DEG/ENaC/ASIC ion channel Pickpocket (Ppk) in the peripheral sensory neurons of developing fruit flies. We used CRISPR-Cas9 genome

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Banke, T. G., S. R. Chaplan, and A. D. Wickenden. "Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation." American Journal of Physiology-Cell Physiology 298, no. 6 (2010): C1457—C1468. http://dx.doi.org/10.1152/ajpcell.00489.2009.

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TRPA1 is a nonselective cation channel belonging to the transient receptor potential (TRP) family that is expressed in peripheral sensory neurons and may play important roles in pain perception and inflammation. We found that agonist stimulation of TRPA1, along with other members of the TRP family (TRPV1–4 and TRPM8), can induce the appearance of a large pore permeable to large organic cations such as Yo-Pro (YP) and N-methyl-d-glucamine, in an agonist and divalent cation-dependent manner. YP uptake was not inhibited by a panel of putative gap junction/pannexin blockers, suggesting that gap ju

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Rossi, Stefano, and Enrico Boni. "Embedded GPU Implementation for High-Performance Ultrasound Imaging." Electronics 10, no. 8 (2021): 884. http://dx.doi.org/10.3390/electronics10080884.

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Methods of increasing complexity are currently being proposed for ultrasound (US) echographic signal processing. Graphics Processing Unit (GPU) resources allowing massive exploitation of parallel computing are ideal candidates for these tasks. Many high-performance US instruments, including open scanners like ULA-OP 256, have an architecture based only on Field-Programmable Gate Arrays (FPGAs) and/or Digital Signal Processors (DSPs). This paper proposes the implementation of the embedded NVIDIA Jetson Xavier AGX module on board ULA-OP 256. The system architecture was revised to allow the intro

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Zhang, Bo Wei, Guo Chang Gu, Xing Zhou Zhang, and Dong Liu. "High Speed Transaction Hardware Channel in Loosely-Coupled Reconfigurable Computing Emulation System." Advanced Materials Research 462 (February 2012): 456–63. http://dx.doi.org/10.4028/www.scientific.net/amr.462.456.

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The loosely-coupled reconfigurable computing model includes the host microprocessor in conjunction with an external stand-alone reconfigurable hardware which takes advantage of low cost in technology and development time. It can work as a fast emulation approach to study reconfigurable computing prototype system. One of the key features of such emulation system is the ability to perform the communication. In this paper, we proposed a high speed hardware channel with direct memory access(DMA) transaction method based on Xilinx ML555 development kit and PCI-express(peripheral component interconn

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Grochmal, Joey, Wulin Teo, Hardeep Gambhir, et al. "A novel approach to 32-channel peripheral nervous system myelin imaging in vivo, with single axon resolution." Journal of Neurosurgery 130, no. 1 (2018): 163–71. http://dx.doi.org/10.3171/2017.6.jns17239.

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OBJECTIVEIntravital spectral imaging of the large, deeply situated nerves in the rat peripheral nervous system (PNS) has not been well described. Here, the authors have developed a highly stable platform for performing imaging of the tibial nerve in live rodents, thus allowing the capture of high-resolution, high-magnification spectral images requiring long acquisition times. By further exploiting the qualities of the topically applied myelin dye Nile red, this technique is capable of visualizing the detailed microenvironment of peripheral nerve demyelination injury and recovery, while allowin

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Koudelkova, Zuzana, Sarka Dankova, Michal Filip, and Marcela Dabrovska. "The Possibility of Using BCI Applications in Physiotherapy." MATEC Web of Conferences 292 (2019): 01033. http://dx.doi.org/10.1051/matecconf/201929201033.

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Brain-Computer Interface (BCI) is an interface connecting the human neural system and computer. This article explains the fundamental principles of BCI and devices, which can be controlled using electroencephalography (EEG). Firstly, this article describes Brain-Computer interface according to obtaining brain activity. After that, the applications of BCI are proposed, which can be used in clinical practice. In the experimental part, the external systems are defined. These external systems are operated by BCI technology. This technology is developed at the Department of Informatics and Artifici

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Youngerman, Brett, Taesung Jung, Nanyu Zeng, et al. "2097 NeuroFlex: A Modular System of Wireless, Fully Implanted, Mechanically Flexible, High-density Subdural and Depth Electrode Arrays." Neurosurgery 71, Supplement_1 (2025): 272–73. https://doi.org/10.1227/neu.0000000000003360_2097.

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INTRODUCTION: Current neural interface technologies suffer from tradeoffs between the density of electrodes, ability to sample from broad networks, and limitations on data transmission and power. Higher channel counts require percutaneous connection to external equipment or are limited by battery-powered, implanted electronics. METHODS: In the Bioelectronic Interface System to the Cortex (BISC), a fully implanted custom integrated circuit thinned to less than 20 µm supports dense recording and stimulation with wireless powering and high-throughput telemetry through an outside-the-body wearable

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ZHANG, Xianchao, and Suresh K. JOSEPH. "Effect of mutation of a calmodulin binding site on Ca2+ regulation of inositol trisphosphate receptors." Biochemical Journal 360, no. 2 (2001): 395–400. http://dx.doi.org/10.1042/bj3600395.

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Several studies have shown that calmodulin (CaM) modulates d-myo-inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) channel activity and ligand binding to IP3Rs. It has been proposed that CaM may act as the Ca2+ sensor for mediating Ca2+ inhibition of IP3R channel activity. However, the functional role of CaM binding sites and the mechanism by which CaM regulates IP3R activities remains unclear. Tryptophan at position 1577 of type I IP3R has been shown to be part of a motif that is responsible for CaM binding to IP3Rs and we have mutated this residue to alanine in the long (neuronal) and short

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Spikes, Tobias E., Martin G. Montgomery, and John E. Walker. "Structure of the dimeric ATP synthase from bovine mitochondria." Proceedings of the National Academy of Sciences 117, no. 38 (2020): 23519–26. http://dx.doi.org/10.1073/pnas.2013998117.

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The structure of the dimeric ATP synthase from bovine mitochondria determined in three rotational states by electron cryo-microscopy provides evidence that the proton uptake from the mitochondrial matrix via the proton inlet half channel proceeds via a Grotthus mechanism, and a similar mechanism may operate in the exit half channel. The structure has given information about the architecture and mechanical constitution and properties of the peripheral stalk, part of the membrane extrinsic region of the stator, and how the action of the peripheral stalk damps the side-to-side rocking motions tha

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Samoylov, A. V., R. V. Khristosenko, N. Ya Gridina, G. V. Dorozinsky, V. V. Romanchuk, and L. Yu Khomenkova. "Dual-channel SPR biosensor for enhanced glioma relapse diagnostics: Blood cell aggregation as a biomarker for tumor malignancy." Semiconductor Physics, Quantum Electronics and Optoelectronics 27, no. 04 (2024): 502–8. https://doi.org/10.15407/spqeo27.04.502.

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A biosensor based on the surface plasmon resonance (SPR) phenomenon has been developed for the express diagnosis of brain gliomas relapse by assessing blood cell aggregation indicators. The device features two optical channels, allowing for two studies to be performed simultaneously or enabling one channel to be used as a reference. This approach significantly increases biosensor sensitivity by reducing the impact of external factors. The optical excitation source is a p-polarized semiconductor laser with a 650 nm wavelength. The sensing elements were F1 optical glass plates with a refractive

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Vasilyev, Dmitry V., Qin Shan, Yan Lee, et al. "Direct Inhibition of Ih by Analgesic Loperamide in Rat DRG Neurons." Journal of Neurophysiology 97, no. 5 (2007): 3713–21. http://dx.doi.org/10.1152/jn.00841.2006.

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Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are responsible for the functional hyperpolarization-activated current ( Ih) in dorsal root ganglion (DRG) neurons, playing an important role in pain processing. We found that the known analgesic loperamide inhibited Ih channels in rat DRG neurons. Loperamide blocked Ih in a concentration-dependent manner, with an IC50 = 4.9 ± 0.6 and 11.0 ± 0.5 μM for large- and small-diameter neurons, respectively. Loperamide-induced Ih inhibition was unrelated to the activation of opioid receptors and was reversible, voltage-dependent, use-i

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Rowe, Ian, Andriy Anishkin, Kishore Kamaraju, Kenjiro Yoshimura, and Sergei Sukharev. "The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding." Journal of General Physiology 143, no. 5 (2014): 543–57. http://dx.doi.org/10.1085/jgp.201311114.

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Cells actively regulate the macromolecular excluded volume of the cytoplasm to maintain the reciprocal fraction of free aqueous solution that is optimal for intracellular processes. However, the mechanisms whereby cells sense this critical parameter remain unclear. The mechanosensitive channel of small conductance (MscS channel), which is the major regulator of turgor in bacteria, mediates efflux of small osmolytes in response to increased membrane tension. At moderate sustained tensions produced by a decrease in external osmolarity, MscS undergoes slow adaptive inactivation; however, it inact

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Baymetova, Elena S., Alena A. Chernova, and Aigul R. Shigapova. "Study of aerodynamics of poorly streamlined bodies using the example of convective heat-exchange apparatus." Himičeskaâ fizika i mezoskopiâ 26, no. 2 (2024): 143–54. http://dx.doi.org/10.62669/17270227.2024.2.13.

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Issues related to the research and study of regularities and features of external aerodynamics of various designs of thermal (including heat exchange) equipment, which are weakly streamlined bodies, remain uncovered and insufficiently studied. However, it is the control of the aerodynamic resistance of a design (aerodynamic imperfection) that can be a convenient criterion for both the thermal efficiency assessment and the optimisation of convective heat exchanger designs. The work is devoted to the study of the aerodynamics of poorly streamlined bodies using the example of a single section of

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Sun, Yong, Li Zhao, Neng Xu, and Rong Ou. "Research of Visual Stimulation Method and Design of Visual Stimulator Based on Brain-Computer Interface." Applied Mechanics and Materials 734 (February 2015): 375–82. http://dx.doi.org/10.4028/www.scientific.net/amm.734.375.

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Brain Computer Interface (BCI) is a new ways of communicating with outside for the loss of some or all of the muscles controlling function of the patients. And the BCI is to set up a new information communication and control channel though the computer or other electronic device between the human brain and the external environment that does not depend on the peripheral nerve and muscle tissue. Firstly, this paper studies the methods of visual stimulation based on Brain Computer Interface that classified by stimulating form can be divided into flash simulation and figures simulation and classif

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Spiers, A., K. Warwick, M. Gasson, and V. Ruiz. "Issues Impairing the Success of Neural Implant Technology." Applied Bionics and Biomechanics 3, no. 4 (2006): 297–304. http://dx.doi.org/10.1155/2006/154724.

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By monitoring signals from the central nervous system, humans can be provided with a novel extra channel of communication that can, for example, be used for the voluntary control of peripheral devices. Meanwhile, stimulation of neural tissue can bring about sensation such as touch, can facilitate feedback from external, potentially remote devices and even opens up the possibility of new sensory input for the individual to experience. The concept of successfully harnessing and stimulating nervous system activity is though something that can only be achieved through an appropriate interface. How

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Bräu, M. E., C. Nau, G. Hempelmann, and W. Vogel. "Local anesthetics potently block a potential insensitive potassium channel in myelinated nerve." Journal of General Physiology 105, no. 4 (1995): 485–505. http://dx.doi.org/10.1085/jgp.105.4.485.

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Effects of some local anesthetics were studied in patch clamp experiments on enzymatically demyelinated peripheral amphibian nerve fibers. Micromolar concentrations of external bupivacaine depolarized the excised membrane considerably. The flicker K+ channel was found to be the most sensitive ion channel to local anesthetics in this preparation. Half-maximum inhibiting concentrations (IC50) for extracellular application of bupivacaine, ropivacaine, etidocaine, mepivacaine, lidocaine, and QX-314 were 0.21, 4.2, 8.6, 56, 220, and &gt; 10,000 microM, respectively. The corresponding concentrat

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Nair, A., A. Turton, D. Stupar, and D. Mansfield. "O026 Concordance between a home sleep apnoea test based on peripheral artery tonometry and laboratory polysomnography." Sleep Advances 4, Supplement_1 (2023): A9. http://dx.doi.org/10.1093/sleepadvances/zpad035.026.

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Abstract Introduction Limited channel home sleep apnoea test (HSAT) devices are an emerging alternative to laboratory-based PSG. Despite increasingly commercially availability, there is limited external validation of their diagnostic performance. We recently independently validated the Night Owl Mini HSAT (NOM) against in-lab PSG and demonstrated a satisfactory level of agreement (LOA) of 63.8% overall. However, lower rates of agreement were observed for severe OSA. We speculated that signal artefact may have contributed to reduced concordance. Methods Data was drawn from our previously publis

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Sarkadi, B., R. Cheung, E. Mack, S. Grinstein, E. W. Gelfand, and A. Rothstein. "Cation and anion transport pathways in volume regulatory response of human lymphocytes to hyposmotic media." American Journal of Physiology-Cell Physiology 248, no. 5 (1985): C480—C487. http://dx.doi.org/10.1152/ajpcell.1985.248.5.c480.

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The regulatory volume decrease of osmotically swollen human peripheral blood lymphocytes can be inhibited by agents acting on volume-activated K+- or Cl--transport pathways. Quinine, cetiedil, and 3,3'-dipropylthiadicarbocyanine were found to block the volume-induced K+ transport by interaction with sites on the outside face of the membrane, perhaps by competition with external K+. Drugs known to influence calmodulin action inhibit both volume-induced K+ and Cl- transport to varying degrees. Those inhibitors, particularly of K+ transport, are correlated with their calmodulin-antagonist activit

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Frieden, B. Roy, and Robert Gatenby. "Ion-Based Cellular Signal Transmission, Principles of Minimum Information Loss, and Evolution by Natural Selection." International Journal of Molecular Sciences 21, no. 1 (2019): 9. http://dx.doi.org/10.3390/ijms21010009.

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The Extreme Physical Information EPI principle states that maximum information transmission or, equivalently, a minimum information loss is a fundamental property of nature. Prior work has demonstrated the universal EPI principle allows derivation of nearly all physical laws. Here, we investigate whether EPI can similarly give rise to the fundamental law of life: Evolution. Living systems require information to survive and proliferate. Heritable information in the genome encodes the structure and function of cellular macromolecules but this information remains fixed over time. In contrast, a c

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De Lorenzo, Emanuele, Serena Pillozzi, Marika Masselli, Olivia Crociani, Andrea Becchetti, and Annarosa Arcangeli. "Potassium Channels as Novel Pharmacological Targets in Acute Myeloid Leukemia." Blood 112, no. 11 (2008): 4034. http://dx.doi.org/10.1182/blood.v112.11.4034.4034.

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Abstract Targeted therapies are considerably changing the treatment and prognosis of hematologic malignancies. The progressive elucidation of the molecular mechanisms that regulate establishment and progression of tumours is leading to more specific and efficacious pharmacological approaches. In this picture, ion channels represent a relatively unexpected, but very promising players. In particular hERG1 channel expression is altered in many primary leukemias and frequently turn out to exert pleiotropic effects on cancer cell physiology, interaction with the external matrix and stimulation of a

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Nyvad, Jakob, Amir Lerman, and Lilach O. Lerman. "With a Little Help From My Friends: the Role of the Renal Collateral Circulation in Atherosclerotic Renovascular Disease." Hypertension 79, no. 4 (2022): 717–25. http://dx.doi.org/10.1161/hypertensionaha.121.17960.

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The collateral circulation can adapt to bypass major arteries with limited flow and serves a crucial protective role in coronary, cerebral, and peripheral arterial disease. Emerging evidence indicates that the renal collateral circulation can similarly adapt and thereby limit kidney ischemia in atherosclerotic renovascular disease. These adaptations predominantly include recruitment of preexisting microvessels for arteriogenesis, with de novo vessel formation playing a limited role. Yet, adaptations of the renal collateral circulation in renovascular disease are often insufficient to fully com

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Gatenby, Robert A. "The Role of Cell Membrane Information Reception, Processing, and Communication in the Structure and Function of Multicellular Tissue." International Journal of Molecular Sciences 20, no. 15 (2019): 3609. http://dx.doi.org/10.3390/ijms20153609.

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Investigations of information dynamics in eukaryotic cells focus almost exclusively on heritable information in the genome. Gene networks are modeled as “central processors” that receive, analyze, and respond to intracellular and extracellular signals with the nucleus described as a cell’s control center. Here, we present a model in which cellular information is a distributed system that includes non-genomic information processing in the cell membrane that may quantitatively exceed that of the genome. Within this model, the nucleus largely acts a source of macromolecules and processes informat

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Fedotova, A., and G. Makarskaya. "Chemiluminescent characteristics of peripheral blood under in vitro irradiation in the dose range of 100–500 mGy." Agrarian Bulletin of the 24, no. 03 (2024): 368–80. http://dx.doi.org/10.32417/1997-4868-2024-24-03-368-380.

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Abstract. Nowadays a lot of examinations are dedicated to determination of radiobiological effects under low doses of ionising radiation. It is known that ionising radiation in the cells of an organism increases generation of reactive oxygen species (ROS). The purpose of the work is to determine basic parameters of chemiluminescent kinetics of ROS in peripheral blood under in vitro radiation in the range of 100–500 mGy doses. The research will extend the knowledge of the impact degree of ionising radiation in low doses on organism tissue of farm animals. Scientific novelty is that the results

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Rohrbough, Jeffrey, and Kendal Broadie. "Electrophysiological Analysis of Synaptic Transmission in Central Neurons of Drosophila Larvae." Journal of Neurophysiology 88, no. 2 (2002): 847–60. http://dx.doi.org/10.1152/jn.2002.88.2.847.

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We report functional neuronal and synaptic transmission properties in DrosophilaCNS neurons. Whole cell current- and voltage-clamp recordings were made from dorsally positioned neurons in the larval ventral nerve cord. Comparison of neuronal Green Fluorescent Protein markers and intracellular dye labeling revealed that recorded cells consisted primarily of identified motor neurons. Neurons had resting potentials of −50 to −60 mV and fired repetitive action potentials (APs) in response to depolarizing current injection. Acetylcholine application elicited large excitatory responses and AP bursts

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Li, Jiayi. "Brain-computer interface for the treatment of mental illness." Theoretical and Natural Science 16, no. 1 (2023): 93–96. http://dx.doi.org/10.54254/2753-8818/16/20240539.

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A brain-computer interface is a direct communication channel between the brain and external devices. Its signals come from the central nervous system, and its transmission is independent of the peripheral nervous and muscular systems. Brain-computer interface commonly used to assist, enhance, and repair human-motor sensations. Through the classification and recognition of Electroencephalogram (EEG) signals, the monitoring and rehabilitation of some neurological and psychological diseases can be realized. Brain-computer interfaces are currently in their infancy and are being explored. Non-invas

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Simchowitz, L., and P. De Weer. "Chloride movements in human neutrophils. Diffusion, exchange, and active transport." Journal of General Physiology 88, no. 2 (1986): 167–94. http://dx.doi.org/10.1085/jgp.88.2.167.

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Chloride content and fluxes were measured in isolated resting human peripheral polymorphonuclear leukocytes. The intracellular Cl concentration of cells kept at 37 degrees C in 148 mM Cl media was approximately 80 meq/liter cell water, fourfold higher than expected for passive distribution at the cell's estimated membrane potential (approximately -53 mV). All intracellular Cl was rapidly exchangeable with external 36Cl. Cells lost Cl exponentially into Cl-free media, and reaccumulated it when Cl was restored to the bath; this reuptake was dependent on metabolism. One-way 36Cl fluxes in steady

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Федотова, А. С. "CHEMILUMINESCENT CHARACTERISTICS OF PERIPHERAL BLOOD WHEN EXPOSED TO “IN VITRO” IONIZING RADIATION AT DOSES OF 5 MGY, 50 MGY AND 500 MGY." VESTNIK RIAZANSKOGO GOSUDARSTVENNOGO AGROTEHNOLOGICHESKOGO UNIVERSITETA IM P A KOSTYCHEVA 15, no. 3(59) (2023): 45–53. http://dx.doi.org/10.36508/rsatu.2023.59.14.007.

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Проблема и цель. В настоящее время оценке радиобиологических эффектов в клетках, тканях и организме в целом при воздействии малых доз ионизирующего излучения посвящено много исследований. Известно, что при воздействии ионизирующего излучения клетки организма увеличивают генерацию активных форм кислорода (АФК). Цель работы – определить основные параметры хемилюминесцентной кинетики АФК в периферической крови при облучении «in vitro» в дозах 5 мГр, 50 мГр и 500 мГр. Исследование расширит представление о степени воздействия малых доз ионизирующего излучения на ткани организма сельскохозяйственных

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Todorovic, Slobodan M., and Christopher J. Lingle. "Pharmacological Properties of T-Type Ca2+ Current in Adult Rat Sensory Neurons: Effects of Anticonvulsant and Anesthetic Agents." Journal of Neurophysiology 79, no. 1 (1998): 240–52. http://dx.doi.org/10.1152/jn.1998.79.1.240.

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Todorovic, Slobodan M. and Christopher J. Lingle. Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. J. Neurophysiol. 79: 240–252, 1998. We have used the whole cell patch-clamp method to study pharmacological properties of low-voltage–activated (LVA) Ca2+ current in freshly dissociated neurons from dorsal root ganglia of adult rats. Inward barium current [in the presence of internal fluoride to reduce L-type high-voltage–activated (HVA) and external 1 μM ω-conotoxin GVIA to blockN-type HVA current] was evoked from ne

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Taras, Maksymyuk, Shubyn Bohdan, Andrushchak Volodymyr, Beshley Halyna, Dumych Stepan, and Klymash Mykhailo. "PRACTICAL IMPLEMENTATION OF THE SOFTWARE DEFINED 5G MOBILE NETWORK BASED ON CLOUD-RAN AND SDR TECHNOLOGIES." Visnyk Universytetu “Ukraina”, no. 1 (28) 2020 (2020): 23–34. http://dx.doi.org/10.36994/2707-4110-2020-1-28-02.

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The paper is devoted to the practical implementation aspects of a software-defined mobile network based on the Cloud-RAN architecture and universal software radio peripheral National Instruments USRP 2900. We propose a multilayer network architecture, which consists of a radio access network (RAN) plane, a core plane, a control plane, an artificial intelligence (AI) plane, and a monitoring system that collects data about network performance. The RAN plane provides all functions related to channel scheduling, data encoding and signal processing and combines all macro and small cells, as well as

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Shushliapina, N. O., A. V. Lupyr, O. O. Taranukha, and O. E. Cherniakova. "Clinical significance of bulbar conjunctive vessel biomicroscopy in patients with pathology of intranisal structures and nasal breathing disoders." Klinical Informatics and Telemedicine 15, no. 16 (2020): 88–98. http://dx.doi.org/10.31071/kit2020.16.09.

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Introduction. The clinical significance of biomicroscopy of bulbar conjunctival vessels in patients with pathology of intranasal structures and nasal breathing disorders was considered. The study of the clinical anatomy of the vascular system is very important in otorhinolaryngology. The conjunctiva of the eye, like the nasal cavity, is supplied with blood from the external and internal carotid arteries. Therefore, the assessment of biomicroscopy of the bulbar conjunctiva can be considered the only functional reflection of mi-crocirculation not only at the level of the body as a whole, but als

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Pylypenko, O. V., N. A. Konovalov, and V. I. Kovalenko. "Compact silencers for new-generation light small arms." Technical mechanics 2021, no. 2 (2021): 20–35. http://dx.doi.org/10.15407/itm2021.02.020.

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This paper presents the results of the development of silencers, whose design feature is a central perforated tube, at the institute of Technical Mechanics of the National Academy of Sciences of Ukraine and the State Space Agency of Ukraine (ITM of NASU and SSAU). The advisability of silencers of this type is confirmed by their operational reliability and shot sound suppression efficiency in their actual service as part of light small arms of different types. To design high-efficiency advanced silencers, technical requirements for their design were developed. The paper describes the possibilit

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Eder, Claudia. "Ion channels in microglia (brain macrophages)." American Journal of Physiology-Cell Physiology 275, no. 2 (1998): C327—C342. http://dx.doi.org/10.1152/ajpcell.1998.275.2.c327.

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Microglia are immunocompetent cells in the brain that have many similarities with macrophages of peripheral tissues. In normal adult brain, microglial cells are in a resting state, but they become activated during inflammation of the central nervous system, after neuronal injury, and in several neurological diseases. Patch-clamp studies of microglial cells in cell culture and in tissue slices demonstrate that microglia express a wide variety of ion channels. Six different types of K+ channels have been identified in microglia, namely, inward rectifier, delayed rectifier, HERG-like, G protein-a

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Glantz, Raymon M., and Andy McIsaac. "Two-Channel Polarization Analyzer in the Sustaining Fiber-Dimming Fiber Ensemble of Crayfish Visual System." Journal of Neurophysiology 80, no. 5 (1998): 2571–83. http://dx.doi.org/10.1152/jn.1998.80.5.2571.

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Glantz, Raymon M. and Andy McIsaac. Two-channel polarization analyzer in the sustaining fiber-dimming fiber ensemble of crayfish visual system. J. Neurophysiol. 80: 2571–2583, 1998. Polarization sensitivity (PS) was examined in two classes of neurons, sustaining fibers and dimming fibers, in the medulla externa (second optic neuropile) of the crayfish, Pacifasticus leniusculus. Visual responses were recorded intracellularly and extracellularly. The influence of e-vector orientation (θ) was probed in steady-state responses, with brief flashes and with a rotating polarizer. The results indicate

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Pizarro-Gómez, Antonio, Giedrė Šadeikaitė, and Francisco Javier García-Delgado. "Changes of Dynamics in Local Productive Systems Based on the Iberian Pig Transformation Industry in Western Sierra Morena (Spain)." Land 10, no. 12 (2021): 1343. http://dx.doi.org/10.3390/land10121343.

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Local Productive Systems (hereinafter LPSs) based on agro-food industries constitute alternative models of development in peripheral rural areas that are subject to internal and external dynamics and processes. The main objective of this research is to investigate these processes and their consequences on four LPSs based on the Iberian Pig Transformation Industry (hereinafter LPS-IPTI) in SW Spain: Fregenal de la Sierra, Higuera la Real, Cumbres Mayores and Jabugo. Using secondary data, a comparison is made between 2002 and 2020 to establish the changes, causes and consequences on the LPS-IPTI

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M, Ragavi, and Subha Sri Lakshmi M.K. "Automation by Brain Sense Through Eeg Waves." International Research Journal of Multidisciplinary Technovation 2, no. 4 (2020): 1–3. http://dx.doi.org/10.34256/irjmt2041.

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Brain Computer Interface (BCI) is one of the communication channels used to make an interaction between human brain and digital computer to control/operate the external devices without having any touch of muscular body part. This provides the easiness in operations and also helpful to elder and decibel people. This is useful for people who cannot operate the peripheral devices using our normal muscular body parts. The proposed system aims to control home appliances (like bulb, fanatic.) with the help of Human Attention Level which come sunder on – invasive method of brains signal measurement.

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Senior, P. V., D. R. Critchley, F. Beck, R. A. Walker, and J. M. Varley. "The localization of laminin mRNA and protein in the postimplantation embryo and placenta of the mouse: an in situ hybridization and immunocytochemical study." Development 104, no. 3 (1988): 431–46. http://dx.doi.org/10.1242/dev.104.3.431.

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In situ hybridization (ISH) and immunocytochemistry were used to localize sites of synthesis and deposition of the basement membrane glycoprotein laminin during development in the postimplantation mouse embryo and extraembryonic membranes. In addition, similar studies were performed on postnatal viscera during the first 20 days after birth. Up to 10 days post coitum, embryonic laminin synthesis was confined to parietal endoderm. In maternal tissue, intense laminin mRNA expression was detected in decidual cells in the mesometrial and antimesometrial endometrium at 5–7 days. At 10 days, uniform

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Kitahara, Seiko, Megumi Yamashita, and Yoshimi Ikemoto. "Effects of pentobarbital on purinergic P2X receptors of rat dorsal root ganglion neurons." Canadian Journal of Physiology and Pharmacology 81, no. 12 (2003): 1085–91. http://dx.doi.org/10.1139/y03-111.

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Purinergic P2X receptors are ligand-gated ion channels that are activated by extracellular adenosine triphosphate (ATP) and are widely expressed not only in the central and peripheral nervous system but also in tissues throughout the body, playing an important role in the transfer of nociceptive information. Since the influence of barbiturates on P2X receptor subtypes is not known, we studied the effects of pentobarbital sodium (PB) on ATP responses in dorsal root ganglion (DRG) neurons. DRG neurons were dissected from 10- to 14-day-old rats and dissociated after enzyme treatment. Electrical m

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Escolar, G., E. Leistikow, and JG White. "The fate of the open canalicular system in surface and suspension- activated platelets." Blood 74, no. 6 (1989): 1983–88. http://dx.doi.org/10.1182/blood.v74.6.1983.bloodjournal7461983.

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We have examined the movement of fibrinogen-gold (fgn-Au) complexes in platelets activated in suspension and by surface contact. Fgn-Au probes did not react with resting cells but were bound to the external membrane of platelets in suspension 5 seconds after addition of 1 U/mL of thrombin. At intervals over a period of 5 to 20 minutes, fgn-Au probes moved from the cell surface to peripheral and then deep channels of the open canalicular system (OCS). When platelets were surface activated by exposure to carbon-stabilized, formvar-coated grids for 5 to 20 minutes and then exposed to fgn-Au compl

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Górka, Andrzej. "Model of a filtration process using a membrane filter with uniform transmission structure." Bulletin of the Military University of Technology 66, no. 3 (2017): 133–53. http://dx.doi.org/10.5604/01.3001.0010.5397.

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The paper presents a model of a microfiltration filter for separation of biological microparticles from body fluids, including peripheral blood. The model used a single membrane filter with a homogeneous 2D transmission structure. In the model, the individual sieve with a uniform transmission structure in 2D space was applied. Because of the required survival of biological particles, the presented model was limited to the narrow filtration conditions that guarantee biological activity of these particles. In this model, the filtration process proceeds in the gravitational field without the invo

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Skrzypiec, P., and R. Szczygieł. "Readout chip with RISC-V microprocessor for hybrid pixel detectors." Journal of Instrumentation 18, no. 01 (2023): C01030. http://dx.doi.org/10.1088/1748-0221/18/01/c01030.

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Abstract Hybrid single-photon counting pixel detectors have recently been widely used for X-ray and ionizing particle detection in medicine, high-energy physics, and material science. Many different chips have been developed for the readout of the semiconductor pixel sensor. Typically, developed ASICs have very limited digital logic and do not provide substantial data processing. In this paper, we present the readout chip that integrates the readout channels matrix with a RISC-V-based microprocessor SoC. The designed device has been prototyped in an FPGA and sent to production in a CMOS 40 nm

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Bhojwani, Deepa, Bradley Peterson, Agne Taraseviciute, et al. "Immunologic and Brain Bases of Neurotoxicity Associated with CAR T-Cell Therapy." Blood 134, Supplement_1 (2019): 1946. http://dx.doi.org/10.1182/blood-2019-127533.

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Introduction: CD19-directed chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment for B-cell acute lymphoblastic leukemia (ALL), inducing complete remission in 70-90% of highly refractory patients. Unfortunately, CAR-T cell therapy is associated with immune effector cell-associated neurotoxicity syndrome (ICANS) in 40% of patients, which presents as confusion, memory impairment, aphasia, altered level of consciousness and/or delirium. The neurobiological and immune bases of ICANS remain poorly understood, and identifying them will help develop strategies for early int

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Escolar, G., E. Leistikow, and JG White. "The fate of the open canalicular system in surface and suspension- activated platelets." Blood 74, no. 6 (1989): 1983–88. http://dx.doi.org/10.1182/blood.v74.6.1983.1983.

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Abstract We have examined the movement of fibrinogen-gold (fgn-Au) complexes in platelets activated in suspension and by surface contact. Fgn-Au probes did not react with resting cells but were bound to the external membrane of platelets in suspension 5 seconds after addition of 1 U/mL of thrombin. At intervals over a period of 5 to 20 minutes, fgn-Au probes moved from the cell surface to peripheral and then deep channels of the open canalicular system (OCS). When platelets were surface activated by exposure to carbon-stabilized, formvar-coated grids for 5 to 20 minutes and then exposed to fgn

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Prates, Daniela, Barbara Fritz, and Luiz Fernando de Paula. "Invited ArticleFrontier-market economies as a new group of the financial periphery: patterns and transmission channels of global shocks." European Journal of Economics and Economic Policies: Intervention 20, no. 2 (2023): 282–98. http://dx.doi.org/10.4337/ejeep.2023.0106.

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This paper seeks to fill a gap in the literature on frontier market economies (FMEs) with the following two research questions: (i) Which are the drivers of FMEs’ integration into financial globalisation? (ii) What explains the greater vulnerability of FMEs compared to emerging market economies (EMEs) to global financial shocks? We argue that the emergence of FMEs as a new group of the financial periphery fills a vacuum left for global investors by the major EMEs, whose spreads declined in the past decade due to high foreign currency reserve accumulation and other EME-related factors. To answe

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