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Journal articles on the topic 'Extra medullary hematopoiesis'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Almomen, Abdulkareem, FarhanAli Anjum, SriHalimah Cana, and MohamedIsam Sharif. "Extra medullary hematopoiesis." Journal of Applied Hematology 5, no. 2 (2014): 73. http://dx.doi.org/10.4103/1658-5127.137179.

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2

Eapen, S. S., R. Narayan, and A. Khan. "A case of unusual extra-medullary hematopoiesis." Journal of Clinical Oncology 22, no. 14_suppl (2004): 6698. http://dx.doi.org/10.1200/jco.2004.22.14_suppl.6698.

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3

Eapen, S. S., R. Narayan, and A. Khan. "A case of unusual extra-medullary hematopoiesis." Journal of Clinical Oncology 22, no. 14_suppl (2004): 6698. http://dx.doi.org/10.1200/jco.2004.22.90140.6698.

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4

Michel, Laure, Elisabeth Auffray-Calvier, Sylvie Raoul, and Pascal Derkinderen. "Spinal cord compression secondary to extra medullary hematopoiesis." Clinical Neurology and Neurosurgery 110, no. 10 (2008): 1073. http://dx.doi.org/10.1016/j.clineuro.2008.08.001.

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Patil, PurwaRangrao, SamruddhiDilip Rajpurkar, Shantilal M. Sisodia, Ajinky Ashok Patil, and Sanjana Ahuja. "Spinal Cord Compression due to Extra Medullary Hematopoiesis in a Case Of Thalassemia Minor." Annals of Pathology and Laboratory Medicine 5, no. 7 (2018): C91–95. http://dx.doi.org/10.21276/apalm.1745.

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6

Baral, R., G. Aryal, and KC Shiva Raj. "Idiopathic myelofibrosis mimicking hemolytic anemia." Journal of Pathology of Nepal 2, no. 4 (2012): 324–27. http://dx.doi.org/10.3126/jpn.v2i4.6888.

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Idiopathic Myelofibrosis is an infrequent chronic myeloproliferative disorder characterized by varying degrees of bone marrow fibrosis and extra medullary hematopoiesis, with the fibrosis being a reactive phenomenon to a neoplastic proliferation of a pluripotent hematopoietic stem cell. Idiopathic Myelofibrosis is heterogeneous in presentation and clinical course, with anemia being one of the most important problems. We present a case of a 59 year old male who presented with severe anemia, the peripheral blood picture mimicking hemolysis with numerous schistocytes and teardrop cells.Journal of

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Jedidi, In#$#egrave;s, Moez Medhaffar, Manel Ghorbel, et al. "Extra medullary hematopoiesis associated to congenital dyserythropoietic anemia II in adult." Annales de biologie clinique 70, no. 2 (2012): 217–20. http://dx.doi.org/10.1684/abc.2012.0694.

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ALJERDAH, M.D., SHAKIR A. "Case Report: Intracranial Extra-Medullary Hematopoiesis in a Child with Osteopetrosis." Medical Journal of Cairo University 86, no. 9 (2018): 2507–10. http://dx.doi.org/10.21608/mjcu.2018.57881.

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Yassin, Mohamed A., Shehab Mohamed, and Abdulqadir Nashwan. "Extra Medullary Hematopoiesis in Patients with Polycythemia Vera Rare and Unusual Presentations." Blood 128, no. 22 (2016): 5491. http://dx.doi.org/10.1182/blood.v128.22.5491.5491.

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Abstract Extramedullary Hematopoisis refers to the presence of hemopoietic elements in locations other than the bone marrow medullary space, it may be seen in many conditions, including chronic hemolytic anemias like thalassemia Intermedia or major. The common sites of involvement are the liver, spleen and the lymph nodes. Less common sites include the central nervous system, adrenal gland, kidney, perirenal soft tissues, breast, peritoneum and gastrointestinal tract the paraspinal region is a relatively uncommon location for these hemopoietic deposits. There are a few case reports of EMH occu

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Mehta, Arnav, David Baltimore, and Jimmy Zhao. "microRNA-132 regulates hematopoietic stem cell function and survival through FOXO3a (HEM5P.226)." Journal of Immunology 194, no. 1_Supplement (2015): 120.6. http://dx.doi.org/10.4049/jimmunol.194.supp.120.6.

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Abstract A complex network of interactions tightly regulates hematopoiesis to ensure balanced and appropriate output of blood cells, both under normal and stressful conditions. This network includes a novel class of RNA molecules, called microRNAs, that do not code for proteins, but instead negatively regulate the expression of genes. These molecules serve as “fine-tuners” of gene expression, and when dysregulated, can drastically alter the balance of hematopoiesis, potentially leading to cancer. We have identified microRNA-132 to be enriched in certain hematopoietic progenitors, particularly

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11

Singh, Inderjit, Geoffrey Mikita, Daniel Green, Cristobal Risquez, and Abraham Sanders. "Pulmonary extra-medullary hematopoiesis and pulmonary hypertension from underlying polycythemia vera: a case series." Pulmonary Circulation 7, no. 1 (2017): 261–67. http://dx.doi.org/10.1177/2045893217702064.

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12

Agarwal, Akriti, and Asha Niranjan Gokhale. "Extramedullary hematopoiesis in ovary: a rare presentation of CML." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 4 (2019): 1689. http://dx.doi.org/10.18203/2320-1770.ijrcog20191244.

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Extramedullary hematopoiesis (EMH) is a rare phenomenon, and represents infiltration and proliferation of myeloid, erythroid, and megakaryocytic cells in non-bone marrow sites. Extramedullary hematopoiesis (EMH) is normal during fetal life, but after birth, the presence of EMH is considered to be abnormal. EMH has been associated with CML (chronic myeloid leukaemia). Lymph node is the most common site of involvement, other sites being the abdomen (liver, spleen) and thorax (bone, mediastinum) but very rarely in the gynecological tract. Here authors report a case of a 20-year young female, a kn

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13

Shangaris, Panicos, Stavros P. Loukogeorgakis, Sindhu Subramaniam, et al. "Correction of Hemoglobin Levels in a Heterozygous Humanized Mouse Model of Thalassemia after Fetal Gene Therapy." Blood 124, no. 21 (2014): 3495. http://dx.doi.org/10.1182/blood.v124.21.3495.3495.

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Abstract Background Beta thalassaemia is a genetic blood disease that causes life-threatening anemia. Hematopoietic stem cell (HSC) transplantation successfully cures the disease but in only 30% of patients. We hypothesized that in utero gene therapy (IUGT) to the fetal HSC compartment with the corrected beta globin gene might cure the disease before birth. Methods A humanized mouse model of thalassemia (Cooley's anemia; CA) was used in which heterozygous animals are affected by anemia, splenomegaly and extra-medullary hematopoiesis. At E13.5 a “GLOBE” vector (HIV-2 based lentiviral vector tha

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14

Pfeiffer, E. A., L. Coppage, and W. F. Conway. "General case of the day. Extra medullary hematopoiesis (EH) in a patient with beta-thalassemia." RadioGraphics 15, no. 1 (1995): 235–38. http://dx.doi.org/10.1148/radiographics.15.1.7899608.

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15

Vanderbeck, Ashley Nicole, Ruben H. Land, Melanie D. Mumau, et al. "Notch signaling directs splenic resident hematopoietic stem cell fate decisions." Journal of Immunology 196, no. 1_Supplement (2016): 190.2. http://dx.doi.org/10.4049/jimmunol.196.supp.190.2.

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Abstract Adult hematopoiesis occurs primarily in the bone marrow (BM), generating mature blood cells as well as maintaining a heterogeneous pool of self-renewing hematopoietic stem cells (HSCs). However, studies suggest that the BM may not be the only site of adult hematopoiesis: during times of BM hematopoietic distress stemming from radiation or disease, the spleen can independently reconstitute the blood. Given that the spleen does indeed contain a small, resident population of lineage-sca1+ckit+CD48-CD150+ long-term (LT)-HSCs with potent reconstitution ability, we investigated the peripher

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16

Paik, Na Yoon, Grace E. Brown, Lijian Shao, et al. "An Ex Vivo Bioengineered Human Liver Microenvironment to Support Hematopoietic Stem Cell Maintenance and Expansion." Blood 136, Supplement 1 (2020): 9–10. http://dx.doi.org/10.1182/blood-2020-141437.

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Over 17,000 people require bone marrow transplants annually, based on the US department of Health and Human Services (https://bloodcell.transplant.hrsa.gov). Despite its high therapeutic value in treatment of cancer and autoimmune disorders, transplant of hematopoietic stem cells (HSC) is limited by the lack of sufficient source material due primarily inadequate expansion of functional HSCs ex vivo. Hence, establishing a system to readily expand human umbilical cord blood or bone marrow HSCs in vitro would greatly support clinical efforts, and provide a readily available source of functional s

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Reinisch, Andreas, Nathalie Etchart, Nicole A. Hofmann, et al. "Organotypic Epigenetic Signature Predicts Bone and Marrow Niche Forming Capacity of Stromal Progenitors in a Novel Mouse Model in Vivo." Blood 120, no. 21 (2012): 2987. http://dx.doi.org/10.1182/blood.v120.21.2987.2987.

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Abstract Abstract 2987 Mesenchymal stem/progenitor cells (MSPCs) from numerous tissues are currently tested in clinical trials despite a limited understanding of their in vivo behavior. In this study we used MSPCs from adult and fetal tissues to select the appropriate source for clinical application. We asked whether MSPCs derived from human bone marrow (BM), white adipose tissue (WAT) and umbilical cord (UC), compared to skin fibroblasts, bear an equivalent bone and marrow niche formation potential with of in vivo. Furthermore we evaluated attraction and engraftment of murine as well as human

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18

Yassin, Mohamed A., Abdulqadir Nashwan, and Shehab Mohamed. "Extramedullary Hematopoiesis in Patients with Primary Myelofibrosis Rare and Serious Complications." Blood 128, no. 22 (2016): 5490. http://dx.doi.org/10.1182/blood.v128.22.5490.5490.

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Abstract Extra Medullary Hematopoiesis refers to the presence of hemopoietic elements in locations other than the bone marrow medullary space,It may be seen in many conditions, including chronic hemolytic anemias like thalassemia Intermedia or major. The common sites of involvement are the liver, spleen and the lymph nodes. Less common sites include the central nervous system, adrenal gland, kidney, perirenal soft tissues, breast, peritoneum and gastrointestinal tract the paraspinal region is a relatively uncommon location for these hemopoietic deposits. There are a few case reports of EMH occ

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19

Gomez, Ingrid, Virginie Robert, Paul Alayrac, et al. "Identification of Adipose Tissue as a Reservoir of Macrophages after Acute Myocardial Infarction." International Journal of Molecular Sciences 23, no. 18 (2022): 10498. http://dx.doi.org/10.3390/ijms231810498.

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Medullary and extra-medullary hematopoiesis has been shown to govern inflammatory cell infiltration and subsequently cardiac remodeling and function after acute myocardial infarction (MI). Emerging evidence positions adipose tissue (AT) as an alternative source of immune cell production. We, therefore, hypothesized that AT could act as a reservoir of inflammatory cells that participate in cardiac homeostasis after MI. To reveal the distinct role of inflammatory cells derived from AT or bone marrow (BM), chimeric mice were generated using standard repopulation assays. We showed that AMI increas

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Moloney, WC. "Radiogenic leukemia revisited." Blood 70, no. 4 (1987): 905–8. http://dx.doi.org/10.1182/blood.v70.4.905.905.

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Abstract Radiation-induced leukemia is considered to be similar to the de novo disease. However, following an analysis of clinical and hematological findings in leukemia occurring in irradiated cervical cancer patients, adult Japanese atomic-bomb survivors, and spondylitics treated with x- ray, striking differences were noted. Acute leukemias in cervical cancer patients and Japanese survivors were similar in type to acute de novo leukemias in adults. Cell types among spondylitics were very dissimilar; rare forms, eg, acute erythromyelocytic leukemia (AEL) and acute megakaryocytic leukemia, wer

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Moloney, WC. "Radiogenic leukemia revisited." Blood 70, no. 4 (1987): 905–8. http://dx.doi.org/10.1182/blood.v70.4.905.bloodjournal704905.

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Radiation-induced leukemia is considered to be similar to the de novo disease. However, following an analysis of clinical and hematological findings in leukemia occurring in irradiated cervical cancer patients, adult Japanese atomic-bomb survivors, and spondylitics treated with x- ray, striking differences were noted. Acute leukemias in cervical cancer patients and Japanese survivors were similar in type to acute de novo leukemias in adults. Cell types among spondylitics were very dissimilar; rare forms, eg, acute erythromyelocytic leukemia (AEL) and acute megakaryocytic leukemia, were increas

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22

Hirsch, R., R. E. Gress, D. H. Pluznik, M. Eckhaus, and J. A. Bluestone. "Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells." Journal of Immunology 142, no. 3 (1989): 737–43. http://dx.doi.org/10.4049/jimmunol.142.3.737.

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Abstract Anti-CD3 mAb are known to be both immunosuppressive and mitogenic to T cells in vitro. However, only immunosuppression has been observed after in vivo administration of these mAb. The present study demonstrates that T cell activation does occur after in vivo administration of anti-CD3 mAb to mice, evidenced by increased IL-2R expression on T cells, CSF secretion, and extra-medullary hematopoiesis in the spleen. These effects required multivalent cross-linking of the mAb, since F(ab')2 fragments failed to induce them. However, the F(ab')2 fragments did induce modulation of CD3/TCR from

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23

Visani, Giuseppe, Maryam Etebari, Fabio Fuligni, et al. "Use of Next Generation Sequencing to Define the Origin of Primary Myelofibrosis." Cancers 15, no. 6 (2023): 1785. http://dx.doi.org/10.3390/cancers15061785.

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Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm (MPN) characterized by progressive bone marrow sclerosis, extra-medullary hematopoiesis, and possible transformation to acute leukemia. In the last decade, the molecular pathogenesis of the disease has been largely uncovered. Particularly, genetic and genomic studies have provided evidence of deregulated oncogenes in PMF as well as in other MPNs. However, the mechanisms through which transformation to either the myeloid or lymphoid blastic phase remain obscure. Particularly, it is still debated whether the disease has origins

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24

Davari, Paran, Cortney Youens Lee, and James Te-An Lee. "A RARE CASE OF RAPIDLY ENLARGING MYELOLIPOMA IN SICKLE CELL DISEASE." AACE Clinical Case Reports 6, no. 2 (2020): e54-e58. http://dx.doi.org/10.4158/accr-2019-0402.

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Objective: Adrenal myelolipoma (AM) is a benign tumor composed of mature fat cells and hemopoietic elements. Most AMs are incidental findings on imaging and clinically asymptomatic. The purpose of this case report is to describe a rare case of AM and explore its clinical manifestations, imaging features, and treatment. Methods: In this study, we report a case of a rapidly growing right AM in a patient with uncontrolled hemoglobin sickle cell disease. A 38-year-old male presented to our institution's endocrine surgery clinic for evaluation of an enlarging right adrenal mass. This mass was incid

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25

Lento, William, Wei Huang, Phuong Doan, Nelson J. Chao, and Luigi Racioppi. "Calcium Calmodulin Dependent Kinase Kinase 2 Regulates Hematopoietic Stem Cell Regeneration and Quiescence." Blood 124, no. 21 (2014): 1571. http://dx.doi.org/10.1182/blood.v124.21.1571.1571.

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Abstract Extracellular free calcium (Ca2+) is the most abundant signaling molecule in the hematopoietic stem cell (HSC) niche, and intracellular calcium is an important second messenger controlling critical functions in HSCs. Accordingly, Ca2+ is a master regulator of HSC biology, and nodes of the Ca2+ signaling network are emerging as critical components of the molecular machinery governing HSC regeneration and quiescence. Ca2+ controls many cell functions by forming a complex with Calmodulin (CaM), which binds and activates a family of Calcium/Calmodulin dependent kinase (CaMK) that includes

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Kumar, Bijender, Mayra Garcia, Guido Marcucci, and Ching-Cheng Chen. "Dicer Ablations in Bone Marrow Niche Impair Hematopoietic Progenitor/Stem Cells and Induce Myelodysplasia in Young Mice but Are Dispensable for Adult Hematopoiesis." Blood 126, no. 23 (2015): 1196. http://dx.doi.org/10.1182/blood.v126.23.1196.1196.

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Abstract MicroRNAs (miRNAs) regulate hematopoietic cell fate and their global down-regulation by Dicer1 deletion promotes tumorigenesis in a cancer-cell-autonomous manner (Kumar M.S. et al, 2007). Raajimakers MH et al. (2010) using neonatal Osterix specific dicer deletion showed altered hematopoiesis and developed myelodysplasia. However, there is no study illustrating the role of the ablation of bone marrow (BM) niche specific miRNA processing machinery in the adult mice. Since expression and functions of different mesenchymal and osteoprogenitors vary from embryonic development to adulthood,

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Alwan, Alaa F. "Clinical features and therapeutic outcome of 30 patients diagnosed with primary myelofibrosis at the national center of hematology." Journal of the Faculty of Medicine Baghdad 56, no. 4 (2015): 362–66. http://dx.doi.org/10.32007/jfacmedbagdad.564545.

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Background: Primary myelofibrosis is characterized by clonal expansion of hematopoietic stem cell with a non-reactive clonal proliferation of fibroblasts and bone marrow fibrosis, which occurs at an extramedullary hematopoiesis. The clinical features of Primary myelofibrosis include anemia, marked splenomegaly and constitutional symptoms. Ineffective erythropoiesis and extra-medullary hematopoiesis are the main causes of anemia and organomegaly, respectively Objectives : the aim of this study was to evaluate the clinical features, diagnostic tools and the treatment outcome of patients with pri

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Imai, Takashi, Kazutomo Suzue, Ha Ngo-Thanh, Chikako Shimokawa, and Hajime Hisaeda. "Potential and Limitations of Cross-Protective Vaccine against Malaria by Blood-Stage Naturally Attenuated Parasite." Vaccines 8, no. 3 (2020): 375. http://dx.doi.org/10.3390/vaccines8030375.

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Human malaria vaccine trials have revealed vaccine efficacy but improvement is still needed. In this study, we aimed to re-evaluate vaccination with blood-stage naturally attenuated parasites, as a whole-organism vaccine model against cross-strain and cross-species malaria, to establish a better vaccination strategy. C57BL/6 mice controlled blood-stage Plasmodium yoelii 17XNL (PyNL) within 1 month of infection, while mice with a variety of immunodeficiencies demonstrated different susceptibilities to PyNL, including succumbing to hyperparasitemia. However, after recovery, survivors had complet

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Wunderlich, Mark, Christina Sexton, Benjamin Mizukawa, and James C. Mulloy. "NSGS Mice Develop a Progressive, Myeloid Cell Dependent Aplastic Anemia and Bone Marrow Failure Upon Engraftment With Human Umbilical Cord Blood CD34+ Cells." Blood 122, no. 21 (2013): 3716. http://dx.doi.org/10.1182/blood.v122.21.3716.3716.

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Abstract One key limitation of hematopoietic xenograft mouse models is the relative lack of effective myelopoiesis compared with human hematopoiesis. NSGS mice expressing human myelo-supportive cytokines allow for improved myeloid cell output upon human hematopoietic cell transfer. Surprisingly, we found that NSGS mice developed a severe, eventually fatal anemia upon humanization with umbilical cord blood (UCB) CD34+ cells. Anemia was characterized by a consistent, progressive drop in red blood cell numbers and hemoglobin that was correlated with higher MCV and an increased reticulocyte produc

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Yathiraj, Prahlad H., Anshul Singh, Sudha Vidyasagar, Muralidhar Varma та Vidyasagar Mamidipudi. "Excellent and durable response to radiotherapy in a rare case of spinal cord compression due to extra-medullary hematopoiesis in β-thalassemia intermedia: case report and clinicoradiological correlation". Annals of Palliative Medicine 6, № 2 (2017): 195–99. http://dx.doi.org/10.21037/apm.2016.12.05.

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31

Chung, Yutein, Huiyan Jin, Claire Trasorras, Francina Gonzalez, and Sang Hee Min. "Megakaryocyte Ablation Ameliorates Bone Marrow Fibrosis By Reducing Myofibroblast Differentiation in a Mouse Model of Primary Myelofibrosis." Blood 134, Supplement_1 (2019): 2493. http://dx.doi.org/10.1182/blood-2019-132186.

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Primary Myelofibrosis (PMF) is a chronic myeloproliferative disorder characterized by excessive bone marrow (BM) fibrosis that can lead to ineffective hematopoiesis and reduced survival. PMF patients develop several megakaryocyte (MK) abnormalities including increased proliferation, abnormal morphology and upregulated expression of pro-fibrotic genes. Although several studies support the role of MK in BM fibrosis, the significance of MK in the development of BM fibrosis has not been demonstrated in vivo. Here, we investigated the in vivo role of MK in the pathogenesis of BM fibrosis. First, we

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Bagryantsev, Maxim Vladimirovich, and Vladimir Vasilevich Ershov. "Clinical Case of Tubular Gastrectomy and Splenectomy, the Bleeding from Vericose Veins of the Stomach and Splenomegaly in the Background Idiopathic Myelofibrosis in Urgent Surgery." Journal of Experimental and Clinical Surgery 12, no. 2 (2019): 123–26. http://dx.doi.org/10.18499/2070-478x-2019-12-2-123-126.

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Relevance. Treatment of patients with surgical complications of oncohematological diseases is difficult due to their inherent critical disorders of blood coagulation, dependence of patients on hormonal drugs taken in connection with the existing pathology, as well as instability of systemic hemodynamics. Such patients are rarely hospitalized in a surgical hospital and can be classified as "difficult patients " because of the polysyndromic nature of the underlying disease and the high risk of death from complications of the disease. One of the most common oncohematological diseases is chr

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Wang, Xiaoli, Joseph Tripodi, Jesse Novak, et al. "JAK2 Inhibitors Do Not Affect Stem Cells Present in the Spleens of Patients with Myelofibrosis." Blood 120, no. 21 (2012): 1752. http://dx.doi.org/10.1182/blood.v120.21.1752.1752.

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Abstract Abstract 1752 Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by abnormal trafficking of hematopoietic stem cells (HSC) and hematopoietic progenitor cells (HPC), resulting in their constitutive mobilization and the establishment of extra-medullary hematopoiesis. At present, there is no known therapeutic approach capable of altering the natural history of MF, except for allogeneic stem cell transplantation. Treatment with JAK2 inhibitors has been shown to lead to a rapid and dramatic reduction of splenomegaly although having only a modest effect on the JAK2V617F allel

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Malara, Alessandro, Cristian Gruppi, Vittorio Abbonante, et al. "EDA Fibronectin-TLR4 Axis Sustains Megakaryocyte Expansion and Inflammation during Bone Marrow Fibrosis Progression." Blood 132, Supplement 1 (2018): 1781. http://dx.doi.org/10.1182/blood-2018-99-116454.

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Abstract Fibronectin (FN) is a glycoprotein of approximately 220 kDa, whose mRNA has three alternative splicing sites (termed EDA, EDB and IIICS) that allow 20 different isoforms of FN mRNA. Circulating plasma FN lacks both EDA and EDB segments and is a soluble form secreted by the hepatocytes, while cellular FN contains variable proportions of EDA and EDB segments and is organized as fibrils in the tissue matrix. FN containing EDA segment (EDA FN) presents unique biochemical properties as compared to the isoform lacking this domain, specifically: 1) pro-fibrotic, as the EDA-containing isoform

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Ojeda-Uribe, Mario, Hanna Sovalat, Laura Jung, et al. "Bloodstream Progenitor-Cell Traffic In Primary Myelofibrosis Reveals Cell Subsets Showing Some Features Of Very-Small Embryonnic-Like Stem Cells (VSELs), Along With Endothelial (PEC), Mesenchymal (MPC) and Hematopoietic (HPC) Progenitor Cells." Blood 122, no. 21 (2013): 5265. http://dx.doi.org/10.1182/blood.v122.21.5265.5265.

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Abstract Introduction Primary myelofibrosis (PMF) is accompanied by an increase in the bloodstream circulation of some adult progenitor cells. Extramedullary hematopoiesis observed in this setting might remind some features related to foetal hematopoiesis. Material and methods We looked for evidence in favour of this hypothesis in blood samples of a small cohort of untreated patients with PMF (4 pre-fibrotic (PF) and 4 fibrotic (F), defined according to the WHO and Thiele's histopathology score (Blood, 2011)). Patient baseline characteristics are shown below. We performed a) flow-cytometric an

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Desterke, Christophe, Nadira Ruzehaji, Bernadette Guerton, et al. "Accessible Chromatin Landscape Reveals a Proliferative Osteoprogenitor Transcriptional Program in Bone Marrow Mesenchymal Stromal Cells from Patients with Primary Myelofibrosis." Blood 128, no. 22 (2016): 3135. http://dx.doi.org/10.1182/blood.v128.22.3135.3135.

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Abstract Primary myelofibrosis (PMF) is chronic myeloproliferative neoplasm characterized by clonal hematopoietic alterations contributing to myeloproliferation, egress of CD34+ cells from bone marrow to spleen associated with extra-medullary hematopoiesis, myelofibrosis with neo-ossification, leading to an osteomyelosclerosis as a result of increased CD146+ osteoprogenitor compartment. Recent studies from our laboratory have reported that bone marrow (BM) mesenchymal stromal cells (MSCs) from PMF patients (PMF-MSCs) showed a transcriptome and functional profile in agreement with an imprinted

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Saeed, Zabila. "Extramedullary Acute Myeloid Leukemia: Testicular Myeloid Leukemia, Leukemia Cutis with Leptomeningeal Involvement." Blood 138, Supplement 1 (2021): 4376. http://dx.doi.org/10.1182/blood-2021-146659.

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Abstract Extramedullary Acute Myeloid Leukemia: Testicular myeloid leukemia, leukemia cutis with leptomeningeal involvement Z Saeed, H Aslam, A Weil, M Muzaffar Myeloid sarcoma also called granulocytic sarcoma, myeloblastoma, or chloroma is an extramedullary tumor of immature granulocytic cells. Extramedullary soft tissue manifestations are relatively rare in hematological malignancies. One of the rarest manifestations is myeloid sarcoma (MS). MS develops as part of acute myeloid leukemia, myeloproliferative neoplasm, or myelodysplastic syndrome or at relapse, especially following allogeneic h

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Oztas, Yesim Er, Esin Oz, Tuba Recber, Sule Unal, Bilgehan Oztas, and Emirhan Nemutlu. "Plasma sphingomyelin levels were negatively correlated with ferritin levels in splenectomized thalassemia patients." American Journal of Clinical Pathology 162, Supplement_1 (2024): S186—S187. http://dx.doi.org/10.1093/ajcp/aqae129.408.

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Abstract Beta thalassemia results from decreased production of beta chains due to either mutations or deletions in the beta-globin gene, leading to impaired production of hemoglobin A. Thalassemia patients take frequent blood transfusions to compensate for hemolytic anemia and iron overload. Iron overload is monitored by serum ferritin levels in these patients. Extra-medullary hematopoiesis in beta thalassemia major leads to hypersplenism which often necessitates splenectomy to increase red cell life span and decrease transfusion need. Sphingomyelin is the second most abundant phospholipid in

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Casu, Carla, Pedro Ramos, Ella Guy, Nico van Rooijen, Robert W. Grady та Stefano Rivella. "Macrophages Impair Erythroid Development in β-Thalassemia Intermedia". Blood 118, № 21 (2011): 1035. http://dx.doi.org/10.1182/blood.v118.21.1035.1035.

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Abstract Abstract 1035 β-Thalassemia is a disorder associated with abnormal β-globin production, leading to anemia, extramedullary hematopoiesis (EMH), a decreased lifespan of the red cells and iron overload. In this disorder erythropoiesis is ineffective due to increased erythroid apoptosis and erythroblast proliferation, as well as deficient differentiation. Recent evidence suggests that erythroid development, especially under conditions of anemia (stress erythropoiesis), is highly dependent on microenvironmental factors within the erythroid niche, potentially mediated by the interaction of

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Earl, Brian, Zi Fan Yang, Harini Rao, Grace Cheng, Donna Wall, and Bo-Yee Ngan. "A Novel Secondary Neoplasm Following Allogeneic Hematopoietic Stem Cell Transplant: Mixed Donor-Recipient Primitive Mesenchymal Proliferation of the Liver." Pediatric and Developmental Pathology 24, no. 4 (2021): 366–70. http://dx.doi.org/10.1177/10935266211001656.

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Post-hematopoietic stem cell transplant secondary solid neoplasms are uncommon and usually host-derived. We describe a 6-year-old female who developed a mixed donor-recipient origin mesenchymal stromal tumor-like lesion in the liver following an unrelated hematopoietic stem cell transplant complicated by severe graft-versus-host disease. This lesion arose early post-transplant in association with hepatic graft-versus-host disease. At 12 years post-transplant, the neoplasm has progressively shrunken in size and the patient remains well with no neoplasm-associated sequelae. This report character

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Das, Rituparna, Till Strowig, Rakesh Verma, et al. "Niche-Dependent Growth of Malignant and Pre-Neoplastic Plasma Cells in Humanized Mice." Blood 126, no. 23 (2015): 120. http://dx.doi.org/10.1182/blood.v126.23.120.120.

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Abstract Multiple myeloma (MM) is characterized by progressive growth of transformed plasma cells (PC) in the bone marrow. In nearly all cases, MM is preceded by clinically asymptomatic precursor states termed as monoclonal gammopathy of undetermined significance (MGUS) and asymptomatic MM (AMM). Almost all prior attempts to study the growth of transformed PCs in vivo have been restricted to patients with clinical MM, and there is an unmet need for in vivo models to understand the biology of precursor states. Major obstacles to xenotransplantation of human cells in immune-deficient mice includ

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Pérez-Gil, Rosaura, Oriana Gavidia, and Juan Torres. "The use of bacterial culture for Leptospirosis di- agnosis in female water buffaloes." Revista Científica de la Facultad de Ciencias Veterinarias 33, Suplemento (2023): 223–24. https://doi.org/10.52973/rcfcv-wbc083.

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The test most used for leptospirosis diagnosis is the Microagglutination Test (MAT). However, the low antibody titers in chronic infections induced by strains adapted to bovines can limit the interpretation of the correct results. The bacteriological culture of Leptospira spp. is the gold standard test because it can demonstrate the agent’s presence. Therefore, this research aimed to reveal the presence of Leptospira spp. in aborted fetuses, genital-urinary secretions of female and male Bubalus bubalis, food raw materials, and rodent feces using bacteriological culture. The analyses were perfo

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Marzolini, Maria, Erika Poggiali, Mohsin Badat, Elena Cassinerio, Maria D. Cappellini, and John B. Porter. "Spinal Artery Thrombosis: An Unrecognized Severe Complication in Thalassemia and Sickle Disorders." Blood 120, no. 21 (2012): 1155. http://dx.doi.org/10.1182/blood.v120.21.1155.1155.

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Abstract Abstract 1155 Introduction. Anterior spinal artery thrombosis (AST) results in sudden, often irreversible sensory and motor loss, with partial or complete paraplegia. This is recognized as a complication of: prothrombotic states; right to left shunting; trauma and spinal surgery. Both venous and arterial thrombosis, including the central nervous system, are well-recognized risks in sickle cell disease (SCD) but AST has not been described. In thalassemia disorders (Thal), cerebral infarction, often silent, is increasingly recognized (Mussalam et al, Thromb Res, Aug 2012). However AST i

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Francis, J., S. Smiley, M. Battiwalla, et al. "Detection of extra-medullary relapse of acute lymphoblastic leukemia by radiographic imaging following allogeneic hematopoietic SCT." Bone Marrow Transplantation 44, no. 12 (2009): 827–28. http://dx.doi.org/10.1038/bmt.2009.183.

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Melchiori, Luca, Ella Guy, Ilaria Libani та ін. "Potential Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Reverse Splenomegaly in β-Thalassemia." Blood 112, № 11 (2008): 1877. http://dx.doi.org/10.1182/blood.v112.11.1877.1877.

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Abstract β-Thalassemia intermedia and major are characterized by ineffective erythropoiesis (IE), requiring sporadic or chronic blood transfusions, respectively. Some of the major consequences of IE are extra-medullary hematopoiesis (EMH), splenomegaly and systemic iron overload mediated by transfusion therapy and down-regulation of hepcidin. Using mouse models of β-thalassemia intermedia (th3/+) and major (th3/th3), and human specimens we investigated IE in this disorder. Th3/+ and th3/th3 erythroid cells were analyzed with respect to rates of apoptosis and degrees of cell proliferation and d

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Ben Ameur El Youbi, A., A. Arioua, M. Ridal, et al. "LARYNGEAL PLASMACYTOMA IN KAHLERS DISEASE: A CASE REPORT." International Journal of Advanced Research 12, no. 02 (2024): 613–18. http://dx.doi.org/10.21474/ijar01/18335.

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Multiple myeloma or Kahlers disease is a malignant hematological disorder due to a monoclonal plasma cell proliferation primarily invading the hematopoietic bone marrow. Extra-medullar involvement occurs in 18% of patients with multiple myeloma. Laryngeal Localization remains rare and has been described in a few cases after a literature review.We report the case of a 44-year-old woman who presented an inspiratory dyspnea caused by a laryngeal tumor. The pathological study and bone marrow examination confirmed the laryngeal localization of multiple myeloma. Treatment consisted of chemotherapy w

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Zhang, Jiwang, Xi He, Sach Jayasinghe, Jason Ross, Jeff Haug, and Linheng Li. "The Roles of Pten in Hematopoietic Stem Cell Regulation and Leukemogenesis." Blood 106, no. 11 (2005): 468. http://dx.doi.org/10.1182/blood.v106.11.468.468.

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Abstract Pten was the first phosphatase identified as a tumor suppressor and one of the most frequently mutated genes involved in human tumor/cancer. Pten, involved in regulation of both PI3K/Akt and MEK/Erk activity, is downstream of growth factor, cytokine, integrin and cadherin signaling pathways and therefore plays important roles in cell growth, survival, differentiation, metabolism and migration. Although Pten mutation is not common in leukemic cells, phosphorylated Pten (p-Pten), which represents the inactive form of Pten, has been observed in a majority of acute myeloid leukemias that

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Guo, Hong, and Alan D. Friedman. "Myeloid Expansion In the Absence of RUNX1 Is Associated with Increased Monopoiesis, Reduced Granulopoiesis, and Diminished CEBPA Gene Expression, Effects of Potential Relevance to Myeloid Transformation." Blood 116, no. 21 (2010): 3147. http://dx.doi.org/10.1182/blood.v116.21.3147.3147.

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Abstract Abstract 3147 RUNX1 directs formation of definitive HSC during development. RUNX1 gene deletion in adult mice leads to multiple hematologic alterations, including expansion of the LSK stem cell population, markedly reduced B and T lymphoid and platelet formation and a myeloid expansion with a 3-fold increase in GMP, a 5-fold increase in myeloid CFUs, expansion of mature myeloid cells in bone marrow, and extra-medullary hematopoiesis with an abundance of maturing myeloid cells in the spleen and liver. The mechanisms underlying the myeloid expansion that occurs in the absence of RUNX1 m

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Melchiori, Luca, Sara Gardenghi, Ella C. Guy та ін. "Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Iron Absorption in Mice Affected by β-Thalassemia and Other Disorders of Red Cell Production." Blood 114, № 22 (2009): 2020. http://dx.doi.org/10.1182/blood.v114.22.2020.2020.

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Abstract Abstract 2020 Poster Board I-1042 β-thalassemia intermedia (TI) and major (TM) are characterized by Ineffective Erythropoiesis (IE). We hypothesized that the kinase Jak2 plays a major role in IE and splenomegaly. To test this hypothesis we administered a Jak2 inhibitor (TG101209) to mice affected by TI, showing that this treatment was associated with a marked decrease in IE, and a moderate decrease in hemoglobin (Hb) levels (∼1 g/dL). This last observation indicates that the use of a Jak2 inhibitor might exacerbate anemia in thalassemia. However, we hypothesized that using standard tr

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Frietsch, Jochen J., Friederike Hunstig, Christoph Wittke, et al. "Extra-medullary recurrence of myeloid leukemia as myeloid sarcoma after allogeneic stem cell transplantation: impact of conditioning intensity." Bone Marrow Transplantation 56, no. 1 (2020): 101–9. http://dx.doi.org/10.1038/s41409-020-0984-4.

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AbstractMyeloid sarcoma (MS) as a solid extra-medullary (EM) manifestation of acute myeloid leukemia (AML), myeloproliferative or myelodysplastic syndromes is a rare presentation of relapse after allogeneic hematopoietic stem cell transplantation (HSCT). The databases of the Departments of Hematology and Oncology of the University Hospitals of Jena and Rostock were screened for patients aged 18 years or older for onset of MS after HSCT for myeloid malignancies between 2002 and 2019. Nineteen patients with MS were identified, the majority of whom had received reduced-intensity conditioning (RIC

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